<?xml version="1.0" encoding="US-ASCII"?>
<!--XBRL Document Created with Wdesk from Workiva-->
<!-- -->
<link:linkbase xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
  <link:roleRef roleURI="http://www.lilly.com/role/AcquisitionsAndDivestiture" xlink:href="lly-20191231.xsd#AcquisitionsAndDivestiture" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/AcquisitionsAndDivestitureAssetAcquisitionsDetails" xlink:href="lly-20191231.xsd#AcquisitionsAndDivestitureAssetAcquisitionsDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/AcquisitionsAndDivestitureNarrativeDetails" xlink:href="lly-20191231.xsd#AcquisitionsAndDivestitureNarrativeDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/AcquisitionsAndDivestiturePolicies" xlink:href="lly-20191231.xsd#AcquisitionsAndDivestiturePolicies" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/AcquisitionsAndDivestiturePurchasePriceAllocationDetails" xlink:href="lly-20191231.xsd#AcquisitionsAndDivestiturePurchasePriceAllocationDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/AcquisitionsAndDivestitureTables" xlink:href="lly-20191231.xsd#AcquisitionsAndDivestitureTables" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/AssetImpairmentRestructuringAndOtherSpecialCharges" xlink:href="lly-20191231.xsd#AssetImpairmentRestructuringAndOtherSpecialCharges" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/AssetImpairmentRestructuringAndOtherSpecialChargesDetails" xlink:href="lly-20191231.xsd#AssetImpairmentRestructuringAndOtherSpecialChargesDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/AssetImpairmentRestructuringAndOtherSpecialChargesNarrativeDetails" xlink:href="lly-20191231.xsd#AssetImpairmentRestructuringAndOtherSpecialChargesNarrativeDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/AssetImpairmentRestructuringAndOtherSpecialChargesTables" xlink:href="lly-20191231.xsd#AssetImpairmentRestructuringAndOtherSpecialChargesTables" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/Borrowings" xlink:href="lly-20191231.xsd#Borrowings" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/BorrowingsNarrativeDetails" xlink:href="lly-20191231.xsd#BorrowingsNarrativeDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/BorrowingsScheduleOfCashPaymentsForInterestOnBorrowingsDetails" xlink:href="lly-20191231.xsd#BorrowingsScheduleOfCashPaymentsForInterestOnBorrowingsDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/BorrowingsScheduleOfDebtMaturitiesDetails" xlink:href="lly-20191231.xsd#BorrowingsScheduleOfDebtMaturitiesDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/BorrowingsScheduleOfLongTermDebtDetails" xlink:href="lly-20191231.xsd#BorrowingsScheduleOfLongTermDebtDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/BorrowingsTables" xlink:href="lly-20191231.xsd#BorrowingsTables" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/CollaborationsAndOtherArrangements" xlink:href="lly-20191231.xsd#CollaborationsAndOtherArrangements" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/CollaborationsAndOtherArrangementsDetails" xlink:href="lly-20191231.xsd#CollaborationsAndOtherArrangementsDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/CollaborationsAndOtherArrangementsMilestonesDeferredCapitalizedDetails" xlink:href="lly-20191231.xsd#CollaborationsAndOtherArrangementsMilestonesDeferredCapitalizedDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/CollaborationsAndOtherArrangementsNetProductRevenueDetails" xlink:href="lly-20191231.xsd#CollaborationsAndOtherArrangementsNetProductRevenueDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/CollaborationsAndOtherArrangementsSignificantMilestonesAchievedDetails" xlink:href="lly-20191231.xsd#CollaborationsAndOtherArrangementsSignificantMilestonesAchievedDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/CollaborationsAndOtherArrangementsTables" xlink:href="lly-20191231.xsd#CollaborationsAndOtherArrangementsTables" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/ConsolidatedBalanceSheets" xlink:href="lly-20191231.xsd#ConsolidatedBalanceSheets" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/ConsolidatedBalanceSheetsParenthetical" xlink:href="lly-20191231.xsd#ConsolidatedBalanceSheetsParenthetical" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/ConsolidatedStatementsOfCashFlows" xlink:href="lly-20191231.xsd#ConsolidatedStatementsOfCashFlows" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/ConsolidatedStatementsOfCashFlowsParenthetical" xlink:href="lly-20191231.xsd#ConsolidatedStatementsOfCashFlowsParenthetical" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/ConsolidatedStatementsOfComprehensiveIncomeLoss" xlink:href="lly-20191231.xsd#ConsolidatedStatementsOfComprehensiveIncomeLoss" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/ConsolidatedStatementsOfOperations" xlink:href="lly-20191231.xsd#ConsolidatedStatementsOfOperations" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/ConsolidatedStatementsOfShareholdersEquityParenthetical" xlink:href="lly-20191231.xsd#ConsolidatedStatementsOfShareholdersEquityParenthetical" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/ConsolidatedStatementsOfShareholdersEquityStatement" xlink:href="lly-20191231.xsd#ConsolidatedStatementsOfShareholdersEquityStatement" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/Contingencies" xlink:href="lly-20191231.xsd#Contingencies" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/ContingenciesDetails" xlink:href="lly-20191231.xsd#ContingenciesDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/ContingenciesPolicies" xlink:href="lly-20191231.xsd#ContingenciesPolicies" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/CoverPage" xlink:href="lly-20191231.xsd#CoverPage" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/DiscontinuedOperations" xlink:href="lly-20191231.xsd#DiscontinuedOperations" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/DiscontinuedOperationsDiscontinuedOperationsInFinancialStatementsDetails" xlink:href="lly-20191231.xsd#DiscontinuedOperationsDiscontinuedOperationsInFinancialStatementsDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/DiscontinuedOperationsMajorClassesOfAssetsAndLiabilitiesDetails" xlink:href="lly-20191231.xsd#DiscontinuedOperationsMajorClassesOfAssetsAndLiabilitiesDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/DiscontinuedOperationsNarrativeDetails" xlink:href="lly-20191231.xsd#DiscontinuedOperationsNarrativeDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/DiscontinuedOperationsTables" xlink:href="lly-20191231.xsd#DiscontinuedOperationsTables" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/FinancialInstruments" xlink:href="lly-20191231.xsd#FinancialInstruments" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/FinancialInstrumentsNarrativeDetails" xlink:href="lly-20191231.xsd#FinancialInstrumentsNarrativeDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/FinancialInstrumentsPolicies" xlink:href="lly-20191231.xsd#FinancialInstrumentsPolicies" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/FinancialInstrumentsScheduleOfAfsUnrealizedGainLossDetails" xlink:href="lly-20191231.xsd#FinancialInstrumentsScheduleOfAfsUnrealizedGainLossDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/FinancialInstrumentsScheduleOfContractualMaturitiesDetails" xlink:href="lly-20191231.xsd#FinancialInstrumentsScheduleOfContractualMaturitiesDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/FinancialInstrumentsScheduleOfEffectOfRiskManagementDetails" xlink:href="lly-20191231.xsd#FinancialInstrumentsScheduleOfEffectOfRiskManagementDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/FinancialInstrumentsScheduleOfFairValueMeasurementDetails" xlink:href="lly-20191231.xsd#FinancialInstrumentsScheduleOfFairValueMeasurementDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/FinancialInstrumentsScheduleOfInvestmentPortfolioActivityDetails" xlink:href="lly-20191231.xsd#FinancialInstrumentsScheduleOfInvestmentPortfolioActivityDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/FinancialInstrumentsScheduleOfRiskManagementInstrumentsDetails" xlink:href="lly-20191231.xsd#FinancialInstrumentsScheduleOfRiskManagementInstrumentsDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/FinancialInstrumentsScheduleOfShortTermAndLongTermClassificationDetails" xlink:href="lly-20191231.xsd#FinancialInstrumentsScheduleOfShortTermAndLongTermClassificationDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/FinancialInstrumentsTables" xlink:href="lly-20191231.xsd#FinancialInstrumentsTables" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/GoodwillAndOtherIntangibles" xlink:href="lly-20191231.xsd#GoodwillAndOtherIntangibles" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/GoodwillAndOtherIntangiblesNarrativeDetails" xlink:href="lly-20191231.xsd#GoodwillAndOtherIntangiblesNarrativeDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/GoodwillAndOtherIntangiblesPolicies" xlink:href="lly-20191231.xsd#GoodwillAndOtherIntangiblesPolicies" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/GoodwillAndOtherIntangiblesScheduleOfAmortizationExpenseDetails" xlink:href="lly-20191231.xsd#GoodwillAndOtherIntangiblesScheduleOfAmortizationExpenseDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/GoodwillAndOtherIntangiblesScheduleOfEstimatedAmortizationExpenseDetails" xlink:href="lly-20191231.xsd#GoodwillAndOtherIntangiblesScheduleOfEstimatedAmortizationExpenseDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/GoodwillAndOtherIntangiblesScheduleOfFiniteLivedAndIndefiniteLivedIntangibleAssetsOtherThanGoodwillDetails" xlink:href="lly-20191231.xsd#GoodwillAndOtherIntangiblesScheduleOfFiniteLivedAndIndefiniteLivedIntangibleAssetsOtherThanGoodwillDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/GoodwillAndOtherIntangiblesTables" xlink:href="lly-20191231.xsd#GoodwillAndOtherIntangiblesTables" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/IncomeTaxes" xlink:href="lly-20191231.xsd#IncomeTaxes" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/IncomeTaxesNarrativeDetails" xlink:href="lly-20191231.xsd#IncomeTaxesNarrativeDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/IncomeTaxesPolicies" xlink:href="lly-20191231.xsd#IncomeTaxesPolicies" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/IncomeTaxesScheduleOfCashPaymentsOfIncomeTaxesDetails" xlink:href="lly-20191231.xsd#IncomeTaxesScheduleOfCashPaymentsOfIncomeTaxesDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/IncomeTaxesScheduleOfCompositionOfIncomeTaxExpenseDetails" xlink:href="lly-20191231.xsd#IncomeTaxesScheduleOfCompositionOfIncomeTaxExpenseDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/IncomeTaxesScheduleOfDeferredTaxAssetAndLiabilitiesDetails" xlink:href="lly-20191231.xsd#IncomeTaxesScheduleOfDeferredTaxAssetAndLiabilitiesDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/IncomeTaxesScheduleOfIncomeTaxBenefitExpenseRelatedToInterestAndPenaltiesDetails" xlink:href="lly-20191231.xsd#IncomeTaxesScheduleOfIncomeTaxBenefitExpenseRelatedToInterestAndPenaltiesDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/IncomeTaxesScheduleOfReconciliationOfIncomeTaxesDetails" xlink:href="lly-20191231.xsd#IncomeTaxesScheduleOfReconciliationOfIncomeTaxesDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/IncomeTaxesScheduleOfUnrecognizedTaxBenefitsDetails" xlink:href="lly-20191231.xsd#IncomeTaxesScheduleOfUnrecognizedTaxBenefitsDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/IncomeTaxesTables" xlink:href="lly-20191231.xsd#IncomeTaxesTables" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/Inventories" xlink:href="lly-20191231.xsd#Inventories" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/InventoriesDetails" xlink:href="lly-20191231.xsd#InventoriesDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/InventoriesPolicies" xlink:href="lly-20191231.xsd#InventoriesPolicies" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/InventoriesTables" xlink:href="lly-20191231.xsd#InventoriesTables" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/Leases" xlink:href="lly-20191231.xsd#Leases" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/LeasesImpactOfLeasesToConsolidatedCondensedFinancialStatementsDetails" xlink:href="lly-20191231.xsd#LeasesImpactOfLeasesToConsolidatedCondensedFinancialStatementsDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/LeasesMaturitiesOfOperatingLeaseLiabilitiesDetails" xlink:href="lly-20191231.xsd#LeasesMaturitiesOfOperatingLeaseLiabilitiesDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/LeasesNarrativeDetails" xlink:href="lly-20191231.xsd#LeasesNarrativeDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/LeasesTables" xlink:href="lly-20191231.xsd#LeasesTables" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/OtherComprehensiveIncomeLoss" xlink:href="lly-20191231.xsd#OtherComprehensiveIncomeLoss" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/OtherComprehensiveIncomeLossScheduleOfComponentOfOtherComprehensiveIncomeLossDetails" xlink:href="lly-20191231.xsd#OtherComprehensiveIncomeLossScheduleOfComponentOfOtherComprehensiveIncomeLossDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/OtherComprehensiveIncomeLossScheduleOfReclassificationsOutOfAccumulatedOtherComprehensiveLossDetails" xlink:href="lly-20191231.xsd#OtherComprehensiveIncomeLossScheduleOfReclassificationsOutOfAccumulatedOtherComprehensiveLossDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/OtherComprehensiveIncomeLossScheduleOfTaxEffectsDetails" xlink:href="lly-20191231.xsd#OtherComprehensiveIncomeLossScheduleOfTaxEffectsDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/OtherComprehensiveIncomeLossTables" xlink:href="lly-20191231.xsd#OtherComprehensiveIncomeLossTables" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/OtherNetIncomeExpense" xlink:href="lly-20191231.xsd#OtherNetIncomeExpense" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/OtherNetIncomeExpenseDetails" xlink:href="lly-20191231.xsd#OtherNetIncomeExpenseDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/OtherNetIncomeExpenseTables" xlink:href="lly-20191231.xsd#OtherNetIncomeExpenseTables" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/PropertyAndEquipment" xlink:href="lly-20191231.xsd#PropertyAndEquipment" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/PropertyAndEquipmentNarrativeDetails" xlink:href="lly-20191231.xsd#PropertyAndEquipmentNarrativeDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/PropertyAndEquipmentPolicies" xlink:href="lly-20191231.xsd#PropertyAndEquipmentPolicies" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/PropertyAndEquipmentScheduleOfDepreciationExpenseDetails" xlink:href="lly-20191231.xsd#PropertyAndEquipmentScheduleOfDepreciationExpenseDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/PropertyAndEquipmentScheduleOfGeographicInformationDetails" xlink:href="lly-20191231.xsd#PropertyAndEquipmentScheduleOfGeographicInformationDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/PropertyAndEquipmentScheduleOfPropertyAndEquipmentDetails" xlink:href="lly-20191231.xsd#PropertyAndEquipmentScheduleOfPropertyAndEquipmentDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/PropertyAndEquipmentTables" xlink:href="lly-20191231.xsd#PropertyAndEquipmentTables" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/RetirementBenefits" xlink:href="lly-20191231.xsd#RetirementBenefits" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/RetirementBenefitsNarrativeDetails" xlink:href="lly-20191231.xsd#RetirementBenefitsNarrativeDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/RetirementBenefitsScheduleOfBenefitObligationsAndPlanAssetsAndFundedStatusDetails" xlink:href="lly-20191231.xsd#RetirementBenefitsScheduleOfBenefitObligationsAndPlanAssetsAndFundedStatusDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/RetirementBenefitsScheduleOfComponentsInConsolidatedBalanceSheetsDetails" xlink:href="lly-20191231.xsd#RetirementBenefitsScheduleOfComponentsInConsolidatedBalanceSheetsDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/RetirementBenefitsScheduleOfExpectedBenefitPaymentsContributionsAndExpenseDetails" xlink:href="lly-20191231.xsd#RetirementBenefitsScheduleOfExpectedBenefitPaymentsContributionsAndExpenseDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/RetirementBenefitsScheduleOfFairValueDisclosuresDetails" xlink:href="lly-20191231.xsd#RetirementBenefitsScheduleOfFairValueDisclosuresDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/RetirementBenefitsScheduleOfWeightedAverageAssumptionsDetails" xlink:href="lly-20191231.xsd#RetirementBenefitsScheduleOfWeightedAverageAssumptionsDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/RetirementBenefitsTables" xlink:href="lly-20191231.xsd#RetirementBenefitsTables" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/Revenue" xlink:href="lly-20191231.xsd#Revenue" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/RevenueContractLiabilitiesDetails" xlink:href="lly-20191231.xsd#RevenueContractLiabilitiesDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/RevenueDisaggregationOfRevenueByGeographicalAreaDetails" xlink:href="lly-20191231.xsd#RevenueDisaggregationOfRevenueByGeographicalAreaDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/RevenueDisaggregationOfRevenueByProductDetails" xlink:href="lly-20191231.xsd#RevenueDisaggregationOfRevenueByProductDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/RevenueNarrativeDetails" xlink:href="lly-20191231.xsd#RevenueNarrativeDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/RevenueSummaryOfRevenueRecognizedDetails" xlink:href="lly-20191231.xsd#RevenueSummaryOfRevenueRecognizedDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/RevenueTables" xlink:href="lly-20191231.xsd#RevenueTables" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/SelectedQuarterlyDataUnaudited" xlink:href="lly-20191231.xsd#SelectedQuarterlyDataUnaudited" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/SelectedQuarterlyDataUnauditedDetails" xlink:href="lly-20191231.xsd#SelectedQuarterlyDataUnauditedDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/SelectedQuarterlyDataUnauditedTables" xlink:href="lly-20191231.xsd#SelectedQuarterlyDataUnauditedTables" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/ShareholdersEquity" xlink:href="lly-20191231.xsd#ShareholdersEquity" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/ShareholdersEquityDetails" xlink:href="lly-20191231.xsd#ShareholdersEquityDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/StockBasedCompensation" xlink:href="lly-20191231.xsd#StockBasedCompensation" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/StockBasedCompensationDetails" xlink:href="lly-20191231.xsd#StockBasedCompensationDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/StockBasedCompensationPolicies" xlink:href="lly-20191231.xsd#StockBasedCompensationPolicies" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/StockBasedCompensationScheduleOfAssumptionsUsedDetails" xlink:href="lly-20191231.xsd#StockBasedCompensationScheduleOfAssumptionsUsedDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/StockBasedCompensationScheduleOfStockBasedCompensationExpenseDetails" xlink:href="lly-20191231.xsd#StockBasedCompensationScheduleOfStockBasedCompensationExpenseDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/StockBasedCompensationTables" xlink:href="lly-20191231.xsd#StockBasedCompensationTables" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/SummaryOfSignificantAccountingPoliciesAndImplementationOfNewFinancialAccountingPronouncementsPolicies" xlink:href="lly-20191231.xsd#SummaryOfSignificantAccountingPoliciesAndImplementationOfNewFinancialAccountingPronouncementsPolicies" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/SummaryOfSignificantAccountingPoliciesAndImplementationOfNewFinancialAccountingStandards" xlink:href="lly-20191231.xsd#SummaryOfSignificantAccountingPoliciesAndImplementationOfNewFinancialAccountingStandards" xlink:type="simple" />
  <link:roleRef roleURI="http://www.lilly.com/role/SummaryOfSignificantAccountingPoliciesAndImplementationOfNewFinancialAccountingStandardsNarrativeDetails" xlink:href="lly-20191231.xsd#SummaryOfSignificantAccountingPoliciesAndImplementationOfNewFinancialAccountingStandardsNarrativeDetails" xlink:type="simple" />
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/all" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#all" xlink:type="simple" />
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-default" xlink:type="simple" />
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-domain" xlink:type="simple" />
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/domain-member" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#domain-member" xlink:type="simple" />
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#hypercube-dimension" xlink:type="simple" />
  <link:definitionLink xlink:role="http://www.lilly.com/role/AcquisitionsAndDivestiture" xlink:type="extended" />
  <link:definitionLink xlink:role="http://www.lilly.com/role/AcquisitionsAndDivestitureAssetAcquisitionsDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_BusinessAcquisitionLineItems" xlink:label="loc_us-gaap_BusinessAcquisitionLineItems_DC5011EB0C3733C5ED555972FC9EC329" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable" xlink:label="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_81EB82FB555857896BA25972FC9B2A8C" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_DC5011EB0C3733C5ED555972FC9EC329" xlink:to="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_81EB82FB555857896BA25972FC9B2A8C" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_BusinessAcquisitionAxis" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_EAC5E394C03958B7EB675972FC9BFDF5" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_81EB82FB555857896BA25972FC9B2A8C" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_EAC5E394C03958B7EB675972FC9BFDF5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_A3A437B78F69C509881F5972FC9B6C93_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_EAC5E394C03958B7EB675972FC9BFDF5" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_A3A437B78F69C509881F5972FC9B6C93_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_A3A437B78F69C509881F5972FC9B6C93" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_EAC5E394C03958B7EB675972FC9BFDF5" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_A3A437B78F69C509881F5972FC9B6C93" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_ACImmuneSAMember" xlink:label="loc_lly_ACImmuneSAMember_C4BC688C6FCDF2198BC15972FC9B70A4" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_A3A437B78F69C509881F5972FC9B6C93" xlink:to="loc_lly_ACImmuneSAMember_C4BC688C6FCDF2198BC15972FC9B70A4" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_ImmuNextInc.Member" xlink:label="loc_lly_ImmuNextInc.Member_D88EC5CBC4E5E9055C2C5972FC9CCCDC" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_A3A437B78F69C509881F5972FC9B6C93" xlink:to="loc_lly_ImmuNextInc.Member_D88EC5CBC4E5E9055C2C5972FC9CCCDC" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_AvidityBiosciencesInc.Member" xlink:label="loc_lly_AvidityBiosciencesInc.Member_13C8EA84F2C7DBF4E1D35972FC9C84DE" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_A3A437B78F69C509881F5972FC9B6C93" xlink:to="loc_lly_AvidityBiosciencesInc.Member_13C8EA84F2C7DBF4E1D35972FC9C84DE" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_CentrexionTherapeuticsCorporationMember" xlink:label="loc_lly_CentrexionTherapeuticsCorporationMember_6F8861FE90384AE56E7A5972FC9CDE7E" xlink:type="locator" />
    <link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_A3A437B78F69C509881F5972FC9B6C93" xlink:to="loc_lly_CentrexionTherapeuticsCorporationMember_6F8861FE90384AE56E7A5972FC9CDE7E" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_SigilonTherapeuticsMember" xlink:label="loc_lly_SigilonTherapeuticsMember_A1D85842BE3625ABB3025972FC9CB820" xlink:type="locator" />
    <link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_A3A437B78F69C509881F5972FC9B6C93" xlink:to="loc_lly_SigilonTherapeuticsMember_A1D85842BE3625ABB3025972FC9CB820" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_AurkaPharmaMember" xlink:label="loc_lly_AurkaPharmaMember_DE653389F7EE1044E4B15972FC9C2AC9" xlink:type="locator" />
    <link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_A3A437B78F69C509881F5972FC9B6C93" xlink:to="loc_lly_AurkaPharmaMember_DE653389F7EE1044E4B15972FC9C2AC9" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_ARMOBiosciencesInc.Member" xlink:label="loc_lly_ARMOBiosciencesInc.Member_F4635F9B32203E71CFF15972FC9D10B9" xlink:type="locator" />
    <link:definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_A3A437B78F69C509881F5972FC9B6C93" xlink:to="loc_lly_ARMOBiosciencesInc.Member_F4635F9B32203E71CFF15972FC9D10B9" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_AnimaBiotechMember" xlink:label="loc_lly_AnimaBiotechMember_79DAFF366C9EAE226B795972FC9D2107" xlink:type="locator" />
    <link:definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_A3A437B78F69C509881F5972FC9B6C93" xlink:to="loc_lly_AnimaBiotechMember_79DAFF366C9EAE226B795972FC9D2107" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_SIGATechnologiesMember" xlink:label="loc_lly_SIGATechnologiesMember_67EBA6A0337AC7AEA8335972FC9D8C0B" xlink:type="locator" />
    <link:definitionArc order="9" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_A3A437B78F69C509881F5972FC9B6C93" xlink:to="loc_lly_SIGATechnologiesMember_67EBA6A0337AC7AEA8335972FC9D8C0B" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_ChugaiPharmaceuticalCompanyMember" xlink:label="loc_lly_ChugaiPharmaceuticalCompanyMember_BFE99B8FE22B77EC22F35972FC9D83F0" xlink:type="locator" />
    <link:definitionArc order="10" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_A3A437B78F69C509881F5972FC9B6C93" xlink:to="loc_lly_ChugaiPharmaceuticalCompanyMember_BFE99B8FE22B77EC22F35972FC9D83F0" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_NextCureInc.Member" xlink:label="loc_lly_NextCureInc.Member_397625F5C76B61638B125972FC9DCE8C" xlink:type="locator" />
    <link:definitionArc order="11" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_A3A437B78F69C509881F5972FC9B6C93" xlink:to="loc_lly_NextCureInc.Member_397625F5C76B61638B125972FC9DCE8C" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_DicernaPharmaceuticalsMember" xlink:label="loc_lly_DicernaPharmaceuticalsMember_1C7C3CB1C01DDBBD17425972FC9DC614" xlink:type="locator" />
    <link:definitionArc order="12" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_A3A437B78F69C509881F5972FC9B6C93" xlink:to="loc_lly_DicernaPharmaceuticalsMember_1C7C3CB1C01DDBBD17425972FC9DC614" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_HydraBiosciencesMember" xlink:label="loc_lly_HydraBiosciencesMember_5D89288AAF03985C04085972FC9E63AF" xlink:type="locator" />
    <link:definitionArc order="13" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_A3A437B78F69C509881F5972FC9B6C93" xlink:to="loc_lly_HydraBiosciencesMember_5D89288AAF03985C04085972FC9E63AF" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_CoLucidPharmaceuticalsMember" xlink:label="loc_lly_CoLucidPharmaceuticalsMember_1A0F941350352D7D08005972FC9EF9FF" xlink:type="locator" />
    <link:definitionArc order="14" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_A3A437B78F69C509881F5972FC9B6C93" xlink:to="loc_lly_CoLucidPharmaceuticalsMember_1A0F941350352D7D08005972FC9EF9FF" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_KeyBiosciencesDualAmylinCalcitoninReceptorAgonistsMember" xlink:label="loc_lly_KeyBiosciencesDualAmylinCalcitoninReceptorAgonistsMember_8082F399D47A6E0D2F615972FC9EA6C3" xlink:type="locator" />
    <link:definitionArc order="15" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_A3A437B78F69C509881F5972FC9B6C93" xlink:to="loc_lly_KeyBiosciencesDualAmylinCalcitoninReceptorAgonistsMember_8082F399D47A6E0D2F615972FC9EA6C3" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_NektarsPhaseIImmunologicalTherapyMember" xlink:label="loc_lly_NektarsPhaseIImmunologicalTherapyMember_3DDA9D221A253B5E5C2C5972FC9EA6D4" xlink:type="locator" />
    <link:definitionArc order="16" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_A3A437B78F69C509881F5972FC9B6C93" xlink:to="loc_lly_NektarsPhaseIImmunologicalTherapyMember_3DDA9D221A253B5E5C2C5972FC9EA6D4" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_CureVacAGMember" xlink:label="loc_lly_CureVacAGMember_07100AE1C0D0791A5C9A5972FC9EC532" xlink:type="locator" />
    <link:definitionArc order="17" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_A3A437B78F69C509881F5972FC9B6C93" xlink:to="loc_lly_CureVacAGMember_07100AE1C0D0791A5C9A5972FC9EC532" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_AcquiredInProcessResearchAndDevelopment" xlink:label="loc_lly_AcquiredInProcessResearchAndDevelopment_4526EC34475B0F41583D5972FC9F491B" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_DC5011EB0C3733C5ED555972FC9EC329" xlink:to="loc_lly_AcquiredInProcessResearchAndDevelopment_4526EC34475B0F41583D5972FC9F491B" xlink:type="arc" />
  </link:definitionLink>
  <link:definitionLink xlink:role="http://www.lilly.com/role/AcquisitionsAndDivestitureNarrativeDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_BusinessAcquisitionLineItems" xlink:label="loc_us-gaap_BusinessAcquisitionLineItems_C540C7761698A08BDD3A5972FCB523AB" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable" xlink:label="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_850693F985D4AD1A06735972FCB189C3" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_C540C7761698A08BDD3A5972FCB523AB" xlink:to="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_850693F985D4AD1A06735972FCB189C3" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SubsequentEventTypeAxis" xlink:label="loc_us-gaap_SubsequentEventTypeAxis_4947889936933C729DA15972FCB1015A" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_850693F985D4AD1A06735972FCB189C3" xlink:to="loc_us-gaap_SubsequentEventTypeAxis_4947889936933C729DA15972FCB1015A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SubsequentEventTypeDomain" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_CA203D1D6874405D4CBD5972FCB15027_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_4947889936933C729DA15972FCB1015A" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_CA203D1D6874405D4CBD5972FCB15027_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SubsequentEventTypeDomain" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_CA203D1D6874405D4CBD5972FCB15027" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_4947889936933C729DA15972FCB1015A" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_CA203D1D6874405D4CBD5972FCB15027" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SubsequentEventMember" xlink:label="loc_us-gaap_SubsequentEventMember_3D585AFA0EB79EADF63F5972FCB2B0C2" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsequentEventTypeDomain_CA203D1D6874405D4CBD5972FCB15027" xlink:to="loc_us-gaap_SubsequentEventMember_3D585AFA0EB79EADF63F5972FCB2B0C2" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DisposalGroupClassificationAxis" xlink:label="loc_us-gaap_DisposalGroupClassificationAxis_8AE2EDD1386AF8E4657A5972FCB21EE1" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_850693F985D4AD1A06735972FCB189C3" xlink:to="loc_us-gaap_DisposalGroupClassificationAxis_8AE2EDD1386AF8E4657A5972FCB21EE1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DisposalGroupClassificationDomain" xlink:label="loc_us-gaap_DisposalGroupClassificationDomain_96CB89445934504820495972FCB2A26D_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DisposalGroupClassificationAxis_8AE2EDD1386AF8E4657A5972FCB21EE1" xlink:to="loc_us-gaap_DisposalGroupClassificationDomain_96CB89445934504820495972FCB2A26D_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DisposalGroupClassificationDomain" xlink:label="loc_us-gaap_DisposalGroupClassificationDomain_96CB89445934504820495972FCB2A26D" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DisposalGroupClassificationAxis_8AE2EDD1386AF8E4657A5972FCB21EE1" xlink:to="loc_us-gaap_DisposalGroupClassificationDomain_96CB89445934504820495972FCB2A26D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DisposalGroupDisposedOfBySaleNotDiscontinuedOperationsMember" xlink:label="loc_us-gaap_DisposalGroupDisposedOfBySaleNotDiscontinuedOperationsMember_9BB6F5FD5121A92791F15972FCB2E9A8" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DisposalGroupClassificationDomain_96CB89445934504820495972FCB2A26D" xlink:to="loc_us-gaap_DisposalGroupDisposedOfBySaleNotDiscontinuedOperationsMember_9BB6F5FD5121A92791F15972FCB2E9A8" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis" xlink:label="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis_B726456A7384D83ADBDF5972FCB3EA6D" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_850693F985D4AD1A06735972FCB189C3" xlink:to="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis_B726456A7384D83ADBDF5972FCB3EA6D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain" xlink:label="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_2C2389371B28869114545972FCB3F177_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis_B726456A7384D83ADBDF5972FCB3EA6D" xlink:to="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_2C2389371B28869114545972FCB3F177_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain" xlink:label="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_2C2389371B28869114545972FCB3F177" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis_B726456A7384D83ADBDF5972FCB3EA6D" xlink:to="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_2C2389371B28869114545972FCB3F177" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_LegacyAntibioticMedicinesAndAManufacturingFacilityInSuzhouChinaMember" xlink:label="loc_lly_LegacyAntibioticMedicinesAndAManufacturingFacilityInSuzhouChinaMember_C520829DF2050FC480815972FCB30BEF" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_2C2389371B28869114545972FCB3F177" xlink:to="loc_lly_LegacyAntibioticMedicinesAndAManufacturingFacilityInSuzhouChinaMember_C520829DF2050FC480815972FCB30BEF" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_CounterpartyNameAxis" xlink:label="loc_srt_CounterpartyNameAxis_770C080570DB90D18B685972FCB35EA0" xlink:type="locator" />
    <link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_850693F985D4AD1A06735972FCB189C3" xlink:to="loc_srt_CounterpartyNameAxis_770C080570DB90D18B685972FCB35EA0" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_RepurchaseAgreementCounterpartyNameDomain" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_46979029B74B34233ABA5972FCB4B680_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_CounterpartyNameAxis_770C080570DB90D18B685972FCB35EA0" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_46979029B74B34233ABA5972FCB4B680_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_RepurchaseAgreementCounterpartyNameDomain" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_46979029B74B34233ABA5972FCB4B680" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_CounterpartyNameAxis_770C080570DB90D18B685972FCB35EA0" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_46979029B74B34233ABA5972FCB4B680" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_EddingpharmMember" xlink:label="loc_lly_EddingpharmMember_3B86F2B3EFFF74B070A15972FCB41765" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_46979029B74B34233ABA5972FCB4B680" xlink:to="loc_lly_EddingpharmMember_3B86F2B3EFFF74B070A15972FCB41765" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_BusinessAcquisitionAxis" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_E7B6B6E0F8DDCC45A12A5972FCB45098" xlink:type="locator" />
    <link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_850693F985D4AD1A06735972FCB189C3" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_E7B6B6E0F8DDCC45A12A5972FCB45098" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_E915FFEBA6806BD759005972FCB43B78_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_E7B6B6E0F8DDCC45A12A5972FCB45098" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_E915FFEBA6806BD759005972FCB43B78_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_E915FFEBA6806BD759005972FCB43B78" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_E7B6B6E0F8DDCC45A12A5972FCB45098" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_E915FFEBA6806BD759005972FCB43B78" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_LoxoOncologyInc.Member" xlink:label="loc_lly_LoxoOncologyInc.Member_FAB281AFA51778686A8A5972FCB5D1DD" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_E915FFEBA6806BD759005972FCB43B78" xlink:to="loc_lly_LoxoOncologyInc.Member_FAB281AFA51778686A8A5972FCB5D1DD" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_DermiraInc.Member" xlink:label="loc_lly_DermiraInc.Member_C3FEE8D60B191E174E3D5972FCB5F436" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_E915FFEBA6806BD759005972FCB43B78" xlink:to="loc_lly_DermiraInc.Member_C3FEE8D60B191E174E3D5972FCB5F436" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_AcquiredInProcessResearchAndDevelopment" xlink:label="loc_lly_AcquiredInProcessResearchAndDevelopment_D8A0DCA7828E62088C165972FCB55E66" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_C540C7761698A08BDD3A5972FCB523AB" xlink:to="loc_lly_AcquiredInProcessResearchAndDevelopment_D8A0DCA7828E62088C165972FCB55E66" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_BusinessCombinationConsiderationTransferred1" xlink:label="loc_us-gaap_BusinessCombinationConsiderationTransferred1_32945A2C930BF05A77E85972FCB617D8" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_C540C7761698A08BDD3A5972FCB523AB" xlink:to="loc_us-gaap_BusinessCombinationConsiderationTransferred1_32945A2C930BF05A77E85972FCB617D8" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_BusinessCombinationProFormaInformationRevenueOfAcquireeSinceAcquisitionDateActual" xlink:label="loc_us-gaap_BusinessCombinationProFormaInformationRevenueOfAcquireeSinceAcquisitionDateActual_8268574B870726C2E1685972FCB67E69" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_C540C7761698A08BDD3A5972FCB523AB" xlink:to="loc_us-gaap_BusinessCombinationProFormaInformationRevenueOfAcquireeSinceAcquisitionDateActual_8268574B870726C2E1685972FCB67E69" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_NumberOfMedicinesRightsToSold" xlink:label="loc_lly_NumberOfMedicinesRightsToSold_717845E310B9A036E0C55972FCB600AF" xlink:type="locator" />
    <link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_C540C7761698A08BDD3A5972FCB523AB" xlink:to="loc_lly_NumberOfMedicinesRightsToSold_717845E310B9A036E0C55972FCB600AF" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ProceedsFromDivestitureOfBusinessesNetOfCashDivested" xlink:label="loc_us-gaap_ProceedsFromDivestitureOfBusinessesNetOfCashDivested_5F4FABBF2D56BA967C255972FCB66CE6" xlink:type="locator" />
    <link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_C540C7761698A08BDD3A5972FCB523AB" xlink:to="loc_us-gaap_ProceedsFromDivestitureOfBusinessesNetOfCashDivested_5F4FABBF2D56BA967C255972FCB66CE6" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_DisposalGroupNotDiscontinuedOperationPaymentToBeReceived" xlink:label="loc_lly_DisposalGroupNotDiscontinuedOperationPaymentToBeReceived_B819190F6A8D24871D915972FCB6B7D9" xlink:type="locator" />
    <link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_C540C7761698A08BDD3A5972FCB523AB" xlink:to="loc_lly_DisposalGroupNotDiscontinuedOperationPaymentToBeReceived_B819190F6A8D24871D915972FCB6B7D9" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DisposalGroupNotDiscontinuedOperationGainLossOnDisposal" xlink:label="loc_us-gaap_DisposalGroupNotDiscontinuedOperationGainLossOnDisposal_A1AA0FD56D2AD6FA82385972FCB6771D" xlink:type="locator" />
    <link:definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_C540C7761698A08BDD3A5972FCB523AB" xlink:to="loc_us-gaap_DisposalGroupNotDiscontinuedOperationGainLossOnDisposal_A1AA0FD56D2AD6FA82385972FCB6771D" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_BusinessCombinationConsiderationTransferredEquityInterestsIssuedAndIssuableCashPaidPerAcquireeShare" xlink:label="loc_lly_BusinessCombinationConsiderationTransferredEquityInterestsIssuedAndIssuableCashPaidPerAcquireeShare_06CF162E38538679BF225972FCB702EB" xlink:type="locator" />
    <link:definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_C540C7761698A08BDD3A5972FCB523AB" xlink:to="loc_lly_BusinessCombinationConsiderationTransferredEquityInterestsIssuedAndIssuableCashPaidPerAcquireeShare_06CF162E38538679BF225972FCB702EB" xlink:type="arc" />
  </link:definitionLink>
  <link:definitionLink xlink:role="http://www.lilly.com/role/AcquisitionsAndDivestiturePolicies" xlink:type="extended" />
  <link:definitionLink xlink:role="http://www.lilly.com/role/AcquisitionsAndDivestiturePurchasePriceAllocationDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_BusinessAcquisitionLineItems" xlink:label="loc_us-gaap_BusinessAcquisitionLineItems_FCF8B92023FF4F0BDE8F5972FCAA7396" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable" xlink:label="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_F2C65EB5A11C4218F8BD5972FCA7CB8A" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_FCF8B92023FF4F0BDE8F5972FCAA7396" xlink:to="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_F2C65EB5A11C4218F8BD5972FCA7CB8A" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_ProductOrServiceAxis" xlink:label="loc_srt_ProductOrServiceAxis_622525F0F013C6BAD03A5972FCA7B393" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_F2C65EB5A11C4218F8BD5972FCA7CB8A" xlink:to="loc_srt_ProductOrServiceAxis_622525F0F013C6BAD03A5972FCA7B393" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_ProductsAndServicesDomain" xlink:label="loc_srt_ProductsAndServicesDomain_6F050AC0EA84B2E09BEF5972FCA8DB1F_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ProductOrServiceAxis_622525F0F013C6BAD03A5972FCA7B393" xlink:to="loc_srt_ProductsAndServicesDomain_6F050AC0EA84B2E09BEF5972FCA8DB1F_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_ProductsAndServicesDomain" xlink:label="loc_srt_ProductsAndServicesDomain_6F050AC0EA84B2E09BEF5972FCA8DB1F" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ProductOrServiceAxis_622525F0F013C6BAD03A5972FCA7B393" xlink:to="loc_srt_ProductsAndServicesDomain_6F050AC0EA84B2E09BEF5972FCA8DB1F" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_SelpercatinibLOXO292Member" xlink:label="loc_lly_SelpercatinibLOXO292Member_FBBEB7F544685E4F06305972FCA8F8E2" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_6F050AC0EA84B2E09BEF5972FCA8DB1F" xlink:to="loc_lly_SelpercatinibLOXO292Member_FBBEB7F544685E4F06305972FCA8F8E2" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_95A519C98675D7D518B35972FCA856EE" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_F2C65EB5A11C4218F8BD5972FCA7CB8A" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_95A519C98675D7D518B35972FCA856EE" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_C48C84D0C0F404935F955972FCA82DAC_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_95A519C98675D7D518B35972FCA856EE" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_C48C84D0C0F404935F955972FCA82DAC_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_C48C84D0C0F404935F955972FCA82DAC" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_95A519C98675D7D518B35972FCA856EE" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_C48C84D0C0F404935F955972FCA82DAC" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ContractBasedIntangibleAssetsMember" xlink:label="loc_us-gaap_ContractBasedIntangibleAssetsMember_19FE93E9DF3B5E474CE65972FCA8778A" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_C48C84D0C0F404935F955972FCA82DAC" xlink:to="loc_us-gaap_ContractBasedIntangibleAssetsMember_19FE93E9DF3B5E474CE65972FCA8778A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_BusinessAcquisitionAxis" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_35C4AF1CB01B5F145BDF5972FCA9D687" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_F2C65EB5A11C4218F8BD5972FCA7CB8A" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_35C4AF1CB01B5F145BDF5972FCA9D687" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_FBFC87206EC3FCBC20FE5972FCA97248_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_35C4AF1CB01B5F145BDF5972FCA9D687" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_FBFC87206EC3FCBC20FE5972FCA97248_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_FBFC87206EC3FCBC20FE5972FCA97248" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_35C4AF1CB01B5F145BDF5972FCA9D687" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_FBFC87206EC3FCBC20FE5972FCA97248" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_LoxoOncologyInc.Member" xlink:label="loc_lly_LoxoOncologyInc.Member_324A80B62F12132DDAD55972FCA93346" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_FBFC87206EC3FCBC20FE5972FCA97248" xlink:to="loc_lly_LoxoOncologyInc.Member_324A80B62F12132DDAD55972FCA93346" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAcquiredInProcessResearchAndDevelopment" xlink:label="loc_lly_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAcquiredInProcessResearchAndDevelopment_A8EE734D6009FBF3A79F5972FCAA7A57" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_FCF8B92023FF4F0BDE8F5972FCAA7396" xlink:to="loc_lly_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAcquiredInProcessResearchAndDevelopment_A8EE734D6009FBF3A79F5972FCAA7A57" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles_BE4536358706B8DBFBEF5972FCAADCA0" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_FCF8B92023FF4F0BDE8F5972FCAA7396" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles_BE4536358706B8DBFBEF5972FCAADCA0" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxLiabilities" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxLiabilities_4EA0A359A4820986AC6A5972FCAA4F26" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_FCF8B92023FF4F0BDE8F5972FCAA7396" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxLiabilities_4EA0A359A4820986AC6A5972FCAA4F26" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedOtherAssetsandLiabilitiesNet" xlink:label="loc_lly_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedOtherAssetsandLiabilitiesNet_A59167C518E0B92751EE5972FCAAFE6D" xlink:type="locator" />
    <link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_FCF8B92023FF4F0BDE8F5972FCAA7396" xlink:to="loc_lly_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedOtherAssetsandLiabilitiesNet_A59167C518E0B92751EE5972FCAAFE6D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_DB7616DD1539FD9118425972FCAA0F65" xlink:type="locator" />
    <link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_FCF8B92023FF4F0BDE8F5972FCAA7396" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_DB7616DD1539FD9118425972FCAA0F65" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_Goodwill" xlink:label="loc_us-gaap_Goodwill_D0775472029A3318F5F85972FCAB51FD" xlink:type="locator" />
    <link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_FCF8B92023FF4F0BDE8F5972FCAA7396" xlink:to="loc_us-gaap_Goodwill_D0775472029A3318F5F85972FCAB51FD" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet_EB8FF920F1BB54F9EA7A5972FCAB81C3" xlink:type="locator" />
    <link:definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_FCF8B92023FF4F0BDE8F5972FCAA7396" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet_EB8FF920F1BB54F9EA7A5972FCAB81C3" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AcquiredFiniteLivedIntangibleAssetsWeightedAverageUsefulLife" xlink:label="loc_us-gaap_AcquiredFiniteLivedIntangibleAssetsWeightedAverageUsefulLife_A4126E39A12987FB9AB15972FCAB7C17" xlink:type="locator" />
    <link:definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_FCF8B92023FF4F0BDE8F5972FCAA7396" xlink:to="loc_us-gaap_AcquiredFiniteLivedIntangibleAssetsWeightedAverageUsefulLife_A4126E39A12987FB9AB15972FCAB7C17" xlink:type="arc" />
  </link:definitionLink>
  <link:definitionLink xlink:role="http://www.lilly.com/role/AcquisitionsAndDivestitureTables" xlink:type="extended" />
  <link:definitionLink xlink:role="http://www.lilly.com/role/AssetImpairmentRestructuringAndOtherSpecialCharges" xlink:type="extended" />
  <link:definitionLink xlink:role="http://www.lilly.com/role/AssetImpairmentRestructuringAndOtherSpecialChargesDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_UnusualOrInfrequentItemLineItems" xlink:label="loc_us-gaap_UnusualOrInfrequentItemLineItems_B368E1EB53F006C2AB90ED56192AD9D9" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_UnusualOrInfrequentItemTable" xlink:label="loc_us-gaap_UnusualOrInfrequentItemTable_7E9EF1FDDC4C4B2A9A03ED56192926C2" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_UnusualOrInfrequentItemLineItems_B368E1EB53F006C2AB90ED56192AD9D9" xlink:to="loc_us-gaap_UnusualOrInfrequentItemTable_7E9EF1FDDC4C4B2A9A03ED56192926C2" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RetirementPlanSponsorLocationAxis" xlink:label="loc_us-gaap_RetirementPlanSponsorLocationAxis_CEA7B3F0AA694783F346ED56192AE3C1" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_UnusualOrInfrequentItemTable_7E9EF1FDDC4C4B2A9A03ED56192926C2" xlink:to="loc_us-gaap_RetirementPlanSponsorLocationAxis_CEA7B3F0AA694783F346ED56192AE3C1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RetirementPlanSponsorLocationDomain" xlink:label="loc_us-gaap_RetirementPlanSponsorLocationDomain_A6DD13B17D897CEA4853ED56192A78F9_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RetirementPlanSponsorLocationAxis_CEA7B3F0AA694783F346ED56192AE3C1" xlink:to="loc_us-gaap_RetirementPlanSponsorLocationDomain_A6DD13B17D897CEA4853ED56192A78F9_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RetirementPlanSponsorLocationDomain" xlink:label="loc_us-gaap_RetirementPlanSponsorLocationDomain_A6DD13B17D897CEA4853ED56192A78F9" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RetirementPlanSponsorLocationAxis_CEA7B3F0AA694783F346ED56192AE3C1" xlink:to="loc_us-gaap_RetirementPlanSponsorLocationDomain_A6DD13B17D897CEA4853ED56192A78F9" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DomesticPlanMember" xlink:label="loc_us-gaap_DomesticPlanMember_95CB1E6003A134F5AD43ED56192ABDA3" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RetirementPlanSponsorLocationDomain_A6DD13B17D897CEA4853ED56192A78F9" xlink:to="loc_us-gaap_DomesticPlanMember_95CB1E6003A134F5AD43ED56192ABDA3" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/country/2017/country-2017-01-31.xsd#country_US" xlink:label="loc_country_US_A36A445FF93F1BF193FDED56192ADFDA" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DomesticPlanMember_95CB1E6003A134F5AD43ED56192ABDA3" xlink:to="loc_country_US_A36A445FF93F1BF193FDED56192ADFDA" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SeveranceCosts1" xlink:label="loc_us-gaap_SeveranceCosts1_A56F48DCB580F96B32DFED56192DB129" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_UnusualOrInfrequentItemLineItems_B368E1EB53F006C2AB90ED56192AD9D9" xlink:to="loc_us-gaap_SeveranceCosts1_A56F48DCB580F96B32DFED56192DB129" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_DefinedBenefitPlanNetPeriodicBenefitCostCreditGainLossDuetoCurtailmentandSpecialTerminationBenefits" xlink:label="loc_lly_DefinedBenefitPlanNetPeriodicBenefitCostCreditGainLossDuetoCurtailmentandSpecialTerminationBenefits_147EF938B522AE77754DED56192DBCBE" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_UnusualOrInfrequentItemLineItems_B368E1EB53F006C2AB90ED56192AD9D9" xlink:to="loc_lly_DefinedBenefitPlanNetPeriodicBenefitCostCreditGainLossDuetoCurtailmentandSpecialTerminationBenefits_147EF938B522AE77754DED56192DBCBE" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AssetImpairmentCharges" xlink:label="loc_us-gaap_AssetImpairmentCharges_9A133F15C18A25706FF6ED56192E6061" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_UnusualOrInfrequentItemLineItems_B368E1EB53F006C2AB90ED56192AD9D9" xlink:to="loc_us-gaap_AssetImpairmentCharges_9A133F15C18A25706FF6ED56192E6061" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RestructuringSettlementAndImpairmentProvisions" xlink:label="loc_us-gaap_RestructuringSettlementAndImpairmentProvisions_AF06DBF8CBCF4FE5DAA8ED56192E5F53" xlink:type="locator" />
    <link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_UnusualOrInfrequentItemLineItems_B368E1EB53F006C2AB90ED56192AD9D9" xlink:to="loc_us-gaap_RestructuringSettlementAndImpairmentProvisions_AF06DBF8CBCF4FE5DAA8ED56192E5F53" xlink:type="arc" />
  </link:definitionLink>
  <link:definitionLink xlink:role="http://www.lilly.com/role/AssetImpairmentRestructuringAndOtherSpecialChargesNarrativeDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RestructuringCostAndReserveLineItems" xlink:label="loc_us-gaap_RestructuringCostAndReserveLineItems_41FE84D453AFB08422DAF803F39ECE7F" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfRestructuringAndRelatedCostsTable" xlink:label="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_01146C244E6BF2686C86F803F39CF99C" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_41FE84D453AFB08422DAF803F39ECE7F" xlink:to="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_01146C244E6BF2686C86F803F39CF99C" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_BusinessAcquisitionAxis" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_E46BCDFDBB52C3795A64F803F39C3476" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_01146C244E6BF2686C86F803F39CF99C" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_E46BCDFDBB52C3795A64F803F39C3476" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_65C3A93802C5EB455CB5F803F39C45B6_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_E46BCDFDBB52C3795A64F803F39C3476" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_65C3A93802C5EB455CB5F803F39C45B6_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_65C3A93802C5EB455CB5F803F39C45B6" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_E46BCDFDBB52C3795A64F803F39C3476" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_65C3A93802C5EB455CB5F803F39C45B6" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_LoxoOncologyInc.Member" xlink:label="loc_lly_LoxoOncologyInc.Member_3B07EDB4A2F84F15BB03F803F39D2915" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_65C3A93802C5EB455CB5F803F39C45B6" xlink:to="loc_lly_LoxoOncologyInc.Member_3B07EDB4A2F84F15BB03F803F39D2915" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_StatementGeographicalAxis" xlink:label="loc_srt_StatementGeographicalAxis_F11D051C4F4C92B8B75CF803F39DD0BC" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_01146C244E6BF2686C86F803F39CF99C" xlink:to="loc_srt_StatementGeographicalAxis_F11D051C4F4C92B8B75CF803F39DD0BC" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_SegmentGeographicalDomain" xlink:label="loc_srt_SegmentGeographicalDomain_3F5CEA75276CE63D3B0DF803F39DB0F2_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_StatementGeographicalAxis_F11D051C4F4C92B8B75CF803F39DD0BC" xlink:to="loc_srt_SegmentGeographicalDomain_3F5CEA75276CE63D3B0DF803F39DB0F2_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_SegmentGeographicalDomain" xlink:label="loc_srt_SegmentGeographicalDomain_3F5CEA75276CE63D3B0DF803F39DB0F2" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_StatementGeographicalAxis_F11D051C4F4C92B8B75CF803F39DD0BC" xlink:to="loc_srt_SegmentGeographicalDomain_3F5CEA75276CE63D3B0DF803F39DB0F2" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/country/2017/country-2017-01-31.xsd#country_US" xlink:label="loc_country_US_BF598A8CFB6F62F19049F803F39D07E1" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_3F5CEA75276CE63D3B0DF803F39DB0F2" xlink:to="loc_country_US_BF598A8CFB6F62F19049F803F39D07E1" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_OutsideUnitedStatesMember" xlink:label="loc_lly_OutsideUnitedStatesMember_04833A8079A6D7F3CD27F803F39E08DE" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_3F5CEA75276CE63D3B0DF803F39DB0F2" xlink:to="loc_lly_OutsideUnitedStatesMember_04833A8079A6D7F3CD27F803F39E08DE" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/country/2017/country-2017-01-31.xsd#country_PR" xlink:label="loc_country_PR_10A6D9F1480D4F1A96AEF803F39EC4CE" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_3F5CEA75276CE63D3B0DF803F39DB0F2" xlink:to="loc_country_PR_10A6D9F1480D4F1A96AEF803F39EC4CE" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SeveranceCosts1" xlink:label="loc_us-gaap_SeveranceCosts1_F0C569BF34CAA875E0C7F803F39EA0BB" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_41FE84D453AFB08422DAF803F39ECE7F" xlink:to="loc_us-gaap_SeveranceCosts1_F0C569BF34CAA875E0C7F803F39EA0BB" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AssetImpairmentCharges" xlink:label="loc_us-gaap_AssetImpairmentCharges_BC42465F8CCCC5FEA1CDF803F39EA3A4" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_41FE84D453AFB08422DAF803F39ECE7F" xlink:to="loc_us-gaap_AssetImpairmentCharges_BC42465F8CCCC5FEA1CDF803F39EA3A4" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_TangibleAssetImpairmentCharges" xlink:label="loc_us-gaap_TangibleAssetImpairmentCharges_D95FA129A9F1EC7D0533F803F39F3D5D" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_41FE84D453AFB08422DAF803F39ECE7F" xlink:to="loc_us-gaap_TangibleAssetImpairmentCharges_D95FA129A9F1EC7D0533F803F39F3D5D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ImpairmentOfIntangibleAssetsExcludingGoodwill" xlink:label="loc_us-gaap_ImpairmentOfIntangibleAssetsExcludingGoodwill_BB3E7E0BB3C4CE58439AF803F39FB17A" xlink:type="locator" />
    <link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_41FE84D453AFB08422DAF803F39ECE7F" xlink:to="loc_us-gaap_ImpairmentOfIntangibleAssetsExcludingGoodwill_BB3E7E0BB3C4CE58439AF803F39FB17A" xlink:type="arc" />
  </link:definitionLink>
  <link:definitionLink xlink:role="http://www.lilly.com/role/AssetImpairmentRestructuringAndOtherSpecialChargesTables" xlink:type="extended" />
  <link:definitionLink xlink:role="http://www.lilly.com/role/Borrowings" xlink:type="extended" />
  <link:definitionLink xlink:role="http://www.lilly.com/role/BorrowingsNarrativeDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtInstrumentLineItems" xlink:label="loc_us-gaap_DebtInstrumentLineItems_8F2B284D8D61C894E8BD0C6CC7848BF9" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtInstrumentTable" xlink:label="loc_us-gaap_DebtInstrumentTable_609D35F4398A55B395840C6CC7804E44" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DebtInstrumentLineItems_8F2B284D8D61C894E8BD0C6CC7848BF9" xlink:to="loc_us-gaap_DebtInstrumentTable_609D35F4398A55B395840C6CC7804E44" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LongtermDebtTypeAxis" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_F1528813E31DC5CB98610C6CC781D39F" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_609D35F4398A55B395840C6CC7804E44" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_F1528813E31DC5CB98610C6CC781D39F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LongtermDebtTypeDomain" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_C67667C5C40515C8BDED0C6CC781A875_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_F1528813E31DC5CB98610C6CC781D39F" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_C67667C5C40515C8BDED0C6CC781A875_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LongtermDebtTypeDomain" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_C67667C5C40515C8BDED0C6CC781A875" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_F1528813E31DC5CB98610C6CC781D39F" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_C67667C5C40515C8BDED0C6CC781A875" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SeniorNotesMember" xlink:label="loc_us-gaap_SeniorNotesMember_50898F7CC21BAF4815320C6CC781D8AE" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_C67667C5C40515C8BDED0C6CC781A875" xlink:to="loc_us-gaap_SeniorNotesMember_50898F7CC21BAF4815320C6CC781D8AE" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NotesPayableToBanksMember" xlink:label="loc_us-gaap_NotesPayableToBanksMember_76EF5D97C9C8BCD6E5120C7A2C80D3B5" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_C67667C5C40515C8BDED0C6CC781A875" xlink:to="loc_us-gaap_NotesPayableToBanksMember_76EF5D97C9C8BCD6E5120C7A2C80D3B5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtInstrumentRedemptionPeriodAxis" xlink:label="loc_us-gaap_DebtInstrumentRedemptionPeriodAxis_A6785396D0199C6263DE0C6CC7822F51" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_609D35F4398A55B395840C6CC7804E44" xlink:to="loc_us-gaap_DebtInstrumentRedemptionPeriodAxis_A6785396D0199C6263DE0C6CC7822F51" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtInstrumentRedemptionPeriodDomain" xlink:label="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_3E24DA895FF3D2F55E000C6CC7828D89_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentRedemptionPeriodAxis_A6785396D0199C6263DE0C6CC7822F51" xlink:to="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_3E24DA895FF3D2F55E000C6CC7828D89_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtInstrumentRedemptionPeriodDomain" xlink:label="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_3E24DA895FF3D2F55E000C6CC7828D89" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentRedemptionPeriodAxis_A6785396D0199C6263DE0C6CC7822F51" xlink:to="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_3E24DA895FF3D2F55E000C6CC7828D89" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_MaturityDate2023Member" xlink:label="loc_lly_MaturityDate2023Member_96592552BB5BA10C16B40C6CC78223E5" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_3E24DA895FF3D2F55E000C6CC7828D89" xlink:to="loc_lly_MaturityDate2023Member_96592552BB5BA10C16B40C6CC78223E5" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_MaturityDate2019Member" xlink:label="loc_lly_MaturityDate2019Member_97E401BF0385FF7AD1C10C6CC78224E8" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_3E24DA895FF3D2F55E000C6CC7828D89" xlink:to="loc_lly_MaturityDate2019Member_97E401BF0385FF7AD1C10C6CC78224E8" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtInstrumentAxis" xlink:label="loc_us-gaap_DebtInstrumentAxis_96CCFCC37ACDC08BE3F80C6CC78380CB" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_609D35F4398A55B395840C6CC7804E44" xlink:to="loc_us-gaap_DebtInstrumentAxis_96CCFCC37ACDC08BE3F80C6CC78380CB" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtInstrumentNameDomain" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_7981CB589E56B21890830C6CC7830DA6_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentAxis_96CCFCC37ACDC08BE3F80C6CC78380CB" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_7981CB589E56B21890830C6CC7830DA6_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtInstrumentNameDomain" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_7981CB589E56B21890830C6CC7830DA6" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentAxis_96CCFCC37ACDC08BE3F80C6CC78380CB" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_7981CB589E56B21890830C6CC7830DA6" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_SeniorNotesDueMarch2029Member" xlink:label="loc_lly_SeniorNotesDueMarch2029Member_AD32F9855B48C563F9B30C6CC783A38C" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_7981CB589E56B21890830C6CC7830DA6" xlink:to="loc_lly_SeniorNotesDueMarch2029Member_AD32F9855B48C563F9B30C6CC783A38C" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_SeniorNotesDueMarch2039Member" xlink:label="loc_lly_SeniorNotesDueMarch2039Member_B81A878DFDD84AAB5EBC0C6CC7830935" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_7981CB589E56B21890830C6CC7830DA6" xlink:to="loc_lly_SeniorNotesDueMarch2039Member_B81A878DFDD84AAB5EBC0C6CC7830935" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_SeniorNotesDueMarch2049Member" xlink:label="loc_lly_SeniorNotesDueMarch2049Member_5473708E37EF5C9FA4FF0C6CC783466A" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_7981CB589E56B21890830C6CC7830DA6" xlink:to="loc_lly_SeniorNotesDueMarch2049Member_5473708E37EF5C9FA4FF0C6CC783466A" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_SeniorNotesDueMarch2059Member" xlink:label="loc_lly_SeniorNotesDueMarch2059Member_F70F3B87643FC5B989310C6CC7849A83" xlink:type="locator" />
    <link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_7981CB589E56B21890830C6CC7830DA6" xlink:to="loc_lly_SeniorNotesDueMarch2059Member_F70F3B87643FC5B989310C6CC7849A83" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_SeniorNotesDueNovember2031Member" xlink:label="loc_lly_SeniorNotesDueNovember2031Member_9A9E6F1FF9ADB0F0CE820C6CC784673A" xlink:type="locator" />
    <link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_7981CB589E56B21890830C6CC7830DA6" xlink:to="loc_lly_SeniorNotesDueNovember2031Member_9A9E6F1FF9ADB0F0CE820C6CC784673A" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_SeniorNotesDueNovember2049Member" xlink:label="loc_lly_SeniorNotesDueNovember2049Member_965129A47F321026957C0C6CC784861C" xlink:type="locator" />
    <link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_7981CB589E56B21890830C6CC7830DA6" xlink:to="loc_lly_SeniorNotesDueNovember2049Member_965129A47F321026957C0C6CC784861C" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_SeniorNotesDueNovember2029Member" xlink:label="loc_lly_SeniorNotesDueNovember2029Member_5D12C16390B7DEB49E930C6CC7846AF1" xlink:type="locator" />
    <link:definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_7981CB589E56B21890830C6CC7830DA6" xlink:to="loc_lly_SeniorNotesDueNovember2029Member_5D12C16390B7DEB49E930C6CC7846AF1" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_SeniorNotesDueNovember2034Member" xlink:label="loc_lly_SeniorNotesDueNovember2034Member_5DE1D79B191534AD68C70C6CC7845BC5" xlink:type="locator" />
    <link:definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_7981CB589E56B21890830C6CC7830DA6" xlink:to="loc_lly_SeniorNotesDueNovember2034Member_5DE1D79B191534AD68C70C6CC7845BC5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShortTermDebtWeightedAverageInterestRate" xlink:label="loc_us-gaap_ShortTermDebtWeightedAverageInterestRate_E58473A0B0A97C20D7320C6CC785AC36" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_8F2B284D8D61C894E8BD0C6CC7848BF9" xlink:to="loc_us-gaap_ShortTermDebtWeightedAverageInterestRate_E58473A0B0A97C20D7320C6CC785AC36" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LineOfCreditFacilityRemainingBorrowingCapacity" xlink:label="loc_us-gaap_LineOfCreditFacilityRemainingBorrowingCapacity_A3DBDCFB063B05DF3F700C6CC785FBF4" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_8F2B284D8D61C894E8BD0C6CC7848BF9" xlink:to="loc_us-gaap_LineOfCreditFacilityRemainingBorrowingCapacity_A3DBDCFB063B05DF3F700C6CC785FBF4" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity" xlink:label="loc_us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity_08BF3965F9C313C96F910C6CC78A415A" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_8F2B284D8D61C894E8BD0C6CC7848BF9" xlink:to="loc_us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity_08BF3965F9C313C96F910C6CC78A415A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtInstrumentTerm" xlink:label="loc_us-gaap_DebtInstrumentTerm_B709E692AFE25779C9B00C6CC78A1202" xlink:type="locator" />
    <link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_8F2B284D8D61C894E8BD0C6CC7848BF9" xlink:to="loc_us-gaap_DebtInstrumentTerm_B709E692AFE25779C9B00C6CC78A1202" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtInstrumentFaceAmount" xlink:label="loc_us-gaap_DebtInstrumentFaceAmount_FE835022CF2124B053DD0C6CC78B65BC" xlink:type="locator" />
    <link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_8F2B284D8D61C894E8BD0C6CC7848BF9" xlink:to="loc_us-gaap_DebtInstrumentFaceAmount_FE835022CF2124B053DD0C6CC78B65BC" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtInstrumentInterestRateStatedPercentage" xlink:label="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_68F888404880CA37D2420C6CC78B3874" xlink:type="locator" />
    <link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_8F2B284D8D61C894E8BD0C6CC7848BF9" xlink:to="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_68F888404880CA37D2420C6CC78B3874" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ProceedsFromIssuanceOfDebt" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfDebt_AA58D155A4642881D14F0C6CC78B1CE3" xlink:type="locator" />
    <link:definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_8F2B284D8D61C894E8BD0C6CC7848BF9" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfDebt_AA58D155A4642881D14F0C6CC78B1CE3" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ProceedsFromRepaymentsOfNotesPayable" xlink:label="loc_us-gaap_ProceedsFromRepaymentsOfNotesPayable_A4D07629C737D817F2FF0C6CC78B2D41" xlink:type="locator" />
    <link:definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_8F2B284D8D61C894E8BD0C6CC7848BF9" xlink:to="loc_us-gaap_ProceedsFromRepaymentsOfNotesPayable_A4D07629C737D817F2FF0C6CC78B2D41" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtInstrumentRepurchaseAmount" xlink:label="loc_us-gaap_DebtInstrumentRepurchaseAmount_7F90FE0B95A38B7D0E050C6CC78B7B4A" xlink:type="locator" />
    <link:definitionArc order="9" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_8F2B284D8D61C894E8BD0C6CC7848BF9" xlink:to="loc_us-gaap_DebtInstrumentRepurchaseAmount_7F90FE0B95A38B7D0E050C6CC78B7B4A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LongTermDebtNoncurrent" xlink:label="loc_us-gaap_LongTermDebtNoncurrent_5D72FAF9252D7AC466240C6CC78BB782" xlink:type="locator" />
    <link:definitionArc order="10" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_8F2B284D8D61C894E8BD0C6CC7848BF9" xlink:to="loc_us-gaap_LongTermDebtNoncurrent_5D72FAF9252D7AC466240C6CC78BB782" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_GainsLossesOnExtinguishmentOfDebt" xlink:label="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_F37C3551851F1D950D540C6CC78CA417" xlink:type="locator" />
    <link:definitionArc order="11" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_8F2B284D8D61C894E8BD0C6CC7848BF9" xlink:to="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_F37C3551851F1D950D540C6CC78CA417" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_DescriptionOfDerivativeActivityVolumePercent" xlink:label="loc_lly_DescriptionOfDerivativeActivityVolumePercent_556A140403F3207B920F0C6CC78CB420" xlink:type="locator" />
    <link:definitionArc order="12" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_8F2B284D8D61C894E8BD0C6CC7848BF9" xlink:to="loc_lly_DescriptionOfDerivativeActivityVolumePercent_556A140403F3207B920F0C6CC78CB420" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtInstrumentInterestRateEffectivePercentage" xlink:label="loc_us-gaap_DebtInstrumentInterestRateEffectivePercentage_54085EFDFD99C4AF06C50C6CC78C7915" xlink:type="locator" />
    <link:definitionArc order="13" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_8F2B284D8D61C894E8BD0C6CC7848BF9" xlink:to="loc_us-gaap_DebtInstrumentInterestRateEffectivePercentage_54085EFDFD99C4AF06C50C6CC78C7915" xlink:type="arc" />
  </link:definitionLink>
  <link:definitionLink xlink:role="http://www.lilly.com/role/BorrowingsScheduleOfCashPaymentsForInterestOnBorrowingsDetails" xlink:type="extended" />
  <link:definitionLink xlink:role="http://www.lilly.com/role/BorrowingsScheduleOfDebtMaturitiesDetails" xlink:type="extended" />
  <link:definitionLink xlink:role="http://www.lilly.com/role/BorrowingsScheduleOfLongTermDebtDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtInstrumentLineItems" xlink:label="loc_us-gaap_DebtInstrumentLineItems_2F9C680F770BB77935E2CA3F3A8F4199" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtInstrumentTable" xlink:label="loc_us-gaap_DebtInstrumentTable_6B787A306A2439C3A5F0CA3F3A8D3687" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DebtInstrumentLineItems_2F9C680F770BB77935E2CA3F3A8F4199" xlink:to="loc_us-gaap_DebtInstrumentTable_6B787A306A2439C3A5F0CA3F3A8D3687" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_RangeAxis" xlink:label="loc_srt_RangeAxis_F9F90A818869E4257102CA3F3A8DFF47" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_6B787A306A2439C3A5F0CA3F3A8D3687" xlink:to="loc_srt_RangeAxis_F9F90A818869E4257102CA3F3A8DFF47" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_RangeMember" xlink:label="loc_srt_RangeMember_089A831FDB53BA19D02FCA3F3A8EA839_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_F9F90A818869E4257102CA3F3A8DFF47" xlink:to="loc_srt_RangeMember_089A831FDB53BA19D02FCA3F3A8EA839_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_RangeMember" xlink:label="loc_srt_RangeMember_089A831FDB53BA19D02FCA3F3A8EA839" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_F9F90A818869E4257102CA3F3A8DFF47" xlink:to="loc_srt_RangeMember_089A831FDB53BA19D02FCA3F3A8EA839" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_MinimumMember" xlink:label="loc_srt_MinimumMember_C8F75BE6975EBBE86295CA3F3A8EE1B3" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_089A831FDB53BA19D02FCA3F3A8EA839" xlink:to="loc_srt_MinimumMember_C8F75BE6975EBBE86295CA3F3A8EE1B3" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_MaximumMember" xlink:label="loc_srt_MaximumMember_E6B94C12841881D8F2E8CA3F3A8FEA25" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_089A831FDB53BA19D02FCA3F3A8EA839" xlink:to="loc_srt_MaximumMember_E6B94C12841881D8F2E8CA3F3A8FEA25" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtInstrumentInterestRateStatedPercentage" xlink:label="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_DEACEB51474C334B5709CA3F3A8F7E55" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_2F9C680F770BB77935E2CA3F3A8F4199" xlink:to="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_DEACEB51474C334B5709CA3F3A8F7E55" xlink:type="arc" />
  </link:definitionLink>
  <link:definitionLink xlink:role="http://www.lilly.com/role/BorrowingsTables" xlink:type="extended" />
  <link:definitionLink xlink:role="http://www.lilly.com/role/CollaborationsAndOtherArrangements" xlink:type="extended" />
  <link:definitionLink xlink:role="http://www.lilly.com/role/CollaborationsAndOtherArrangementsDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems" xlink:label="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_27D1EB428E07A9A072CEAE57C78D70BB" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable" xlink:label="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_086ACDEC39D2815285C6AE57C78B6837" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_27D1EB428E07A9A072CEAE57C78D70BB" xlink:to="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_086ACDEC39D2815285C6AE57C78B6837" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_ProductOrServiceAxis" xlink:label="loc_srt_ProductOrServiceAxis_E88805D5EA20A41AC6DFAE57C78BF16D" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_086ACDEC39D2815285C6AE57C78B6837" xlink:to="loc_srt_ProductOrServiceAxis_E88805D5EA20A41AC6DFAE57C78BF16D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_ProductsAndServicesDomain" xlink:label="loc_srt_ProductsAndServicesDomain_11B03147885B359297F6AE57C78BB08F_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ProductOrServiceAxis_E88805D5EA20A41AC6DFAE57C78BF16D" xlink:to="loc_srt_ProductsAndServicesDomain_11B03147885B359297F6AE57C78BB08F_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_ProductsAndServicesDomain" xlink:label="loc_srt_ProductsAndServicesDomain_11B03147885B359297F6AE57C78BB08F" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ProductOrServiceAxis_E88805D5EA20A41AC6DFAE57C78BF16D" xlink:to="loc_srt_ProductsAndServicesDomain_11B03147885B359297F6AE57C78BB08F" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_OlumiantMember" xlink:label="loc_lly_OlumiantMember_3E7D9B328EF9FDF3365BAE57C78CAD19" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_11B03147885B359297F6AE57C78BB08F" xlink:to="loc_lly_OlumiantMember_3E7D9B328EF9FDF3365BAE57C78CAD19" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_TanezumabMember" xlink:label="loc_lly_TanezumabMember_D6D17CA1234EA85304D9AE57C78CA182" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_11B03147885B359297F6AE57C78BB08F" xlink:to="loc_lly_TanezumabMember_D6D17CA1234EA85304D9AE57C78CA182" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_TypeOfArrangementAxis" xlink:label="loc_us-gaap_TypeOfArrangementAxis_80C73C36B2651AAF40CDAE57C78C5FE6" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_086ACDEC39D2815285C6AE57C78B6837" xlink:to="loc_us-gaap_TypeOfArrangementAxis_80C73C36B2651AAF40CDAE57C78C5FE6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_A0063DB656EDA668AF34AE57C78C1B44_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_TypeOfArrangementAxis_80C73C36B2651AAF40CDAE57C78C5FE6" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_A0063DB656EDA668AF34AE57C78C1B44_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_A0063DB656EDA668AF34AE57C78C1B44" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_TypeOfArrangementAxis_80C73C36B2651AAF40CDAE57C78C5FE6" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_A0063DB656EDA668AF34AE57C78C1B44" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RoyaltyAgreementTermsMember" xlink:label="loc_us-gaap_RoyaltyAgreementTermsMember_30AB181C207005592C02AE57C78DB14A" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_A0063DB656EDA668AF34AE57C78C1B44" xlink:to="loc_us-gaap_RoyaltyAgreementTermsMember_30AB181C207005592C02AE57C78DB14A" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_MilestonePaymentsDevelopmentAndRegulatoryMember" xlink:label="loc_lly_MilestonePaymentsDevelopmentAndRegulatoryMember_DFFF533E233400A939FCAE57C78D5920" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_A0063DB656EDA668AF34AE57C78C1B44" xlink:to="loc_lly_MilestonePaymentsDevelopmentAndRegulatoryMember_DFFF533E233400A939FCAE57C78D5920" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_MilestonePaymentsSalesBasedMember" xlink:label="loc_lly_MilestonePaymentsSalesBasedMember_478EBCB32301DF7A188EAE57C78D5B25" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_A0063DB656EDA668AF34AE57C78C1B44" xlink:to="loc_lly_MilestonePaymentsSalesBasedMember_478EBCB32301DF7A188EAE57C78D5B25" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_ResearchAndDevelopmentExpMember" xlink:label="loc_lly_ResearchAndDevelopmentExpMember_E2DF3DBCA5D128BCB217AE57C78DB76B" xlink:type="locator" />
    <link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_A0063DB656EDA668AF34AE57C78C1B44" xlink:to="loc_lly_ResearchAndDevelopmentExpMember_E2DF3DBCA5D128BCB217AE57C78DB76B" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_CollaborativeArrangementRightsAndObligationsPercent" xlink:label="loc_lly_CollaborativeArrangementRightsAndObligationsPercent_518DD2285057FEC492F1AE57C78E2752" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_27D1EB428E07A9A072CEAE57C78D70BB" xlink:to="loc_lly_CollaborativeArrangementRightsAndObligationsPercent_518DD2285057FEC492F1AE57C78E2752" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_CollaborativeArrangementRightsAndObligationsTerms" xlink:label="loc_lly_CollaborativeArrangementRightsAndObligationsTerms_E8E999CB0782E2D6A404AE57C78E4606" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_27D1EB428E07A9A072CEAE57C78D70BB" xlink:to="loc_lly_CollaborativeArrangementRightsAndObligationsTerms_E8E999CB0782E2D6A404AE57C78E4606" xlink:type="arc" />
  </link:definitionLink>
  <link:definitionLink xlink:role="http://www.lilly.com/role/CollaborationsAndOtherArrangementsMilestonesDeferredCapitalizedDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems" xlink:label="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_278C8BB8B7ABB3D93860F778C86C3F98" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable" xlink:label="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_8C34ECFDFC9932B0E019F778C86A175F" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_278C8BB8B7ABB3D93860F778C86C3F98" xlink:to="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_8C34ECFDFC9932B0E019F778C86A175F" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_TypeOfArrangementAxis" xlink:label="loc_us-gaap_TypeOfArrangementAxis_FA382A85A71931E32060F778C86A8C54" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_8C34ECFDFC9932B0E019F778C86A175F" xlink:to="loc_us-gaap_TypeOfArrangementAxis_FA382A85A71931E32060F778C86A8C54" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_14FCA206E68ADDD56ED7F778C86AABC5_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_TypeOfArrangementAxis_FA382A85A71931E32060F778C86A8C54" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_14FCA206E68ADDD56ED7F778C86AABC5_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_14FCA206E68ADDD56ED7F778C86AABC5" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_TypeOfArrangementAxis_FA382A85A71931E32060F778C86A8C54" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_14FCA206E68ADDD56ED7F778C86AABC5" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_MilestonePaymentsDevelopmentandRegulatoryCapitalizedDeferredCumulativeMember" xlink:label="loc_lly_MilestonePaymentsDevelopmentandRegulatoryCapitalizedDeferredCumulativeMember_77780475790897ED866CF778C86B94B9" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_14FCA206E68ADDD56ED7F778C86AABC5" xlink:to="loc_lly_MilestonePaymentsDevelopmentandRegulatoryCapitalizedDeferredCumulativeMember_77780475790897ED866CF778C86B94B9" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_ProductOrServiceAxis" xlink:label="loc_srt_ProductOrServiceAxis_174112FD94A8E380BF29F778C86B20FC" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_8C34ECFDFC9932B0E019F778C86A175F" xlink:to="loc_srt_ProductOrServiceAxis_174112FD94A8E380BF29F778C86B20FC" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_ProductsAndServicesDomain" xlink:label="loc_srt_ProductsAndServicesDomain_7EBE811D247C4166D6C0F778C86BB35A_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ProductOrServiceAxis_174112FD94A8E380BF29F778C86B20FC" xlink:to="loc_srt_ProductsAndServicesDomain_7EBE811D247C4166D6C0F778C86BB35A_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_ProductsAndServicesDomain" xlink:label="loc_srt_ProductsAndServicesDomain_7EBE811D247C4166D6C0F778C86BB35A" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ProductOrServiceAxis_174112FD94A8E380BF29F778C86B20FC" xlink:to="loc_srt_ProductsAndServicesDomain_7EBE811D247C4166D6C0F778C86BB35A" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_TrajentaBIMember" xlink:label="loc_lly_TrajentaBIMember_0742E5BA06723BAC13BCF778C86BCFF8" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_7EBE811D247C4166D6C0F778C86BB35A" xlink:to="loc_lly_TrajentaBIMember_0742E5BA06723BAC13BCF778C86BCFF8" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_JardianceMember" xlink:label="loc_lly_JardianceMember_D762ED6A10E473765F0AF778C86CC471" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_7EBE811D247C4166D6C0F778C86BB35A" xlink:to="loc_lly_JardianceMember_D762ED6A10E473765F0AF778C86CC471" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_BasaglarMember" xlink:label="loc_lly_BasaglarMember_7FB2C0E337FE59995EB4F778C86C28B8" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_7EBE811D247C4166D6C0F778C86BB35A" xlink:to="loc_lly_BasaglarMember_7FB2C0E337FE59995EB4F778C86C28B8" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_CollaborativeArrangementRightsAndObligationsTerms" xlink:label="loc_lly_CollaborativeArrangementRightsAndObligationsTerms_CBAC2B81AE92DD0750D9F778C86C2269" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_278C8BB8B7ABB3D93860F778C86C3F98" xlink:to="loc_lly_CollaborativeArrangementRightsAndObligationsTerms_CBAC2B81AE92DD0750D9F778C86C2269" xlink:type="arc" />
  </link:definitionLink>
  <link:definitionLink xlink:role="http://www.lilly.com/role/CollaborationsAndOtherArrangementsNetProductRevenueDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems" xlink:label="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_27B543BC6C66F5459718F778C86672F4" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable" xlink:label="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_65A83EFA9CA6C4B8D8D3F778C8645907" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_27B543BC6C66F5459718F778C86672F4" xlink:to="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_65A83EFA9CA6C4B8D8D3F778C8645907" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_ProductOrServiceAxis" xlink:label="loc_srt_ProductOrServiceAxis_BC645247EB76AD9D2844F778C8645B95" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_65A83EFA9CA6C4B8D8D3F778C8645907" xlink:to="loc_srt_ProductOrServiceAxis_BC645247EB76AD9D2844F778C8645B95" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_ProductsAndServicesDomain" xlink:label="loc_srt_ProductsAndServicesDomain_1827BA8F29E16176BC00F778C865DA75_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ProductOrServiceAxis_BC645247EB76AD9D2844F778C8645B95" xlink:to="loc_srt_ProductsAndServicesDomain_1827BA8F29E16176BC00F778C865DA75_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_ProductsAndServicesDomain" xlink:label="loc_srt_ProductsAndServicesDomain_1827BA8F29E16176BC00F778C865DA75" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ProductOrServiceAxis_BC645247EB76AD9D2844F778C8645B95" xlink:to="loc_srt_ProductsAndServicesDomain_1827BA8F29E16176BC00F778C865DA75" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_BasaglarMember" xlink:label="loc_lly_BasaglarMember_AF78418C2F2D86DA02A1F778C865B33E" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_1827BA8F29E16176BC00F778C865DA75" xlink:to="loc_lly_BasaglarMember_AF78418C2F2D86DA02A1F778C865B33E" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_JardianceMember" xlink:label="loc_lly_JardianceMember_8BEE62C06B59B52442ABF778C86515A6" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_1827BA8F29E16176BC00F778C865DA75" xlink:to="loc_lly_JardianceMember_8BEE62C06B59B52442ABF778C86515A6" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_TrajentaBIMember" xlink:label="loc_lly_TrajentaBIMember_5FADAFB6E0D63FA8C379F778C8650709" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_1827BA8F29E16176BC00F778C865DA75" xlink:to="loc_lly_TrajentaBIMember_5FADAFB6E0D63FA8C379F778C8650709" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_Revenues" xlink:label="loc_us-gaap_Revenues_C0E842A4C8DB609D35B2F778C866BB4E" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_27B543BC6C66F5459718F778C86672F4" xlink:to="loc_us-gaap_Revenues_C0E842A4C8DB609D35B2F778C866BB4E" xlink:type="arc" />
  </link:definitionLink>
  <link:definitionLink xlink:role="http://www.lilly.com/role/CollaborationsAndOtherArrangementsSignificantMilestonesAchievedDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems" xlink:label="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_27A91DF8BE6DA4F0BF2B5E4E056E2A24" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable" xlink:label="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_4951888836082244AD5B5E4E056B53DC" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_27A91DF8BE6DA4F0BF2B5E4E056E2A24" xlink:to="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_4951888836082244AD5B5E4E056B53DC" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_StatementGeographicalAxis" xlink:label="loc_srt_StatementGeographicalAxis_56E4D83B5213032CD7135E4E056C5CF2" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_4951888836082244AD5B5E4E056B53DC" xlink:to="loc_srt_StatementGeographicalAxis_56E4D83B5213032CD7135E4E056C5CF2" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_SegmentGeographicalDomain" xlink:label="loc_srt_SegmentGeographicalDomain_EBFA4E1B8435580965C45E4E056CA5F9_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_StatementGeographicalAxis_56E4D83B5213032CD7135E4E056C5CF2" xlink:to="loc_srt_SegmentGeographicalDomain_EBFA4E1B8435580965C45E4E056CA5F9_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_SegmentGeographicalDomain" xlink:label="loc_srt_SegmentGeographicalDomain_EBFA4E1B8435580965C45E4E056CA5F9" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_StatementGeographicalAxis_56E4D83B5213032CD7135E4E056C5CF2" xlink:to="loc_srt_SegmentGeographicalDomain_EBFA4E1B8435580965C45E4E056CA5F9" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/country/2017/country-2017-01-31.xsd#country_US" xlink:label="loc_country_US_76C6B408B9FE2AED2AEC5E4E056C5356" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_EBFA4E1B8435580965C45E4E056CA5F9" xlink:to="loc_country_US_76C6B408B9FE2AED2AEC5E4E056C5356" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_EuropeMember" xlink:label="loc_srt_EuropeMember_1DA1A6E1EBC79B5190245E4E056DF923" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_EBFA4E1B8435580965C45E4E056CA5F9" xlink:to="loc_srt_EuropeMember_1DA1A6E1EBC79B5190245E4E056DF923" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/country/2017/country-2017-01-31.xsd#country_JP" xlink:label="loc_country_JP_C7606263FAD09809207F5E4E056D53D8" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_EBFA4E1B8435580965C45E4E056CA5F9" xlink:to="loc_country_JP_C7606263FAD09809207F5E4E056D53D8" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_TypeOfArrangementAxis" xlink:label="loc_us-gaap_TypeOfArrangementAxis_86080EDFB62405533DDE5E4E056DC7AE" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_4951888836082244AD5B5E4E056B53DC" xlink:to="loc_us-gaap_TypeOfArrangementAxis_86080EDFB62405533DDE5E4E056DC7AE" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_4C18D060EDA5AC1C97875E4E056D23C8_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_TypeOfArrangementAxis_86080EDFB62405533DDE5E4E056DC7AE" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_4C18D060EDA5AC1C97875E4E056D23C8_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_4C18D060EDA5AC1C97875E4E056D23C8" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_TypeOfArrangementAxis_86080EDFB62405533DDE5E4E056DC7AE" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_4C18D060EDA5AC1C97875E4E056D23C8" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_MilestonePaymentsDevelopmentandRegulatoryCapitalizedDeferredMember" xlink:label="loc_lly_MilestonePaymentsDevelopmentandRegulatoryCapitalizedDeferredMember_D8B7E6FF320675AD8BF25E4E056DDBEC" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_4C18D060EDA5AC1C97875E4E056D23C8" xlink:to="loc_lly_MilestonePaymentsDevelopmentandRegulatoryCapitalizedDeferredMember_D8B7E6FF320675AD8BF25E4E056DDBEC" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_MilestonePaymentsDevelopmentandRegulatoryExpensedMember" xlink:label="loc_lly_MilestonePaymentsDevelopmentandRegulatoryExpensedMember_BA22C98B687F1061D8095E4E056E0786" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_4C18D060EDA5AC1C97875E4E056D23C8" xlink:to="loc_lly_MilestonePaymentsDevelopmentandRegulatoryExpensedMember_BA22C98B687F1061D8095E4E056E0786" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_ProductOrServiceAxis" xlink:label="loc_srt_ProductOrServiceAxis_E4A1212A3134B31D1A185E4E056EBD8E" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_4951888836082244AD5B5E4E056B53DC" xlink:to="loc_srt_ProductOrServiceAxis_E4A1212A3134B31D1A185E4E056EBD8E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_ProductsAndServicesDomain" xlink:label="loc_srt_ProductsAndServicesDomain_153B91DAE80A44A222215E4E056EADEB_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ProductOrServiceAxis_E4A1212A3134B31D1A185E4E056EBD8E" xlink:to="loc_srt_ProductsAndServicesDomain_153B91DAE80A44A222215E4E056EADEB_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_ProductsAndServicesDomain" xlink:label="loc_srt_ProductsAndServicesDomain_153B91DAE80A44A222215E4E056EADEB" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ProductOrServiceAxis_E4A1212A3134B31D1A185E4E056EBD8E" xlink:to="loc_srt_ProductsAndServicesDomain_153B91DAE80A44A222215E4E056EADEB" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_OlumiantMember" xlink:label="loc_lly_OlumiantMember_21AA7109CFDF8D24F0345E4E056E2863" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_153B91DAE80A44A222215E4E056EADEB" xlink:to="loc_lly_OlumiantMember_21AA7109CFDF8D24F0345E4E056E2863" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_CollaborativeArrangementRightsAndObligationsTerms" xlink:label="loc_lly_CollaborativeArrangementRightsAndObligationsTerms_A37B654872CAA08267A65E4E056FB41B" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_27A91DF8BE6DA4F0BF2B5E4E056E2A24" xlink:to="loc_lly_CollaborativeArrangementRightsAndObligationsTerms_A37B654872CAA08267A65E4E056FB41B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ResearchAndDevelopmentExpense" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_9BBE955C0F7448328FAC5E4E056F8ED7" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_27A91DF8BE6DA4F0BF2B5E4E056E2A24" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_9BBE955C0F7448328FAC5E4E056F8ED7" xlink:type="arc" />
  </link:definitionLink>
  <link:definitionLink xlink:role="http://www.lilly.com/role/CollaborationsAndOtherArrangementsTables" xlink:type="extended" />
  <link:definitionLink xlink:role="http://www.lilly.com/role/ConsolidatedBalanceSheets" xlink:type="extended" />
  <link:definitionLink xlink:role="http://www.lilly.com/role/ConsolidatedBalanceSheetsParenthetical" xlink:type="extended" />
  <link:definitionLink xlink:role="http://www.lilly.com/role/ConsolidatedStatementsOfCashFlows" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_39BEAE268F930DA4581D5972FD19A814" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementTable" xlink:label="loc_us-gaap_StatementTable_909D96EF18FF1B012ED75972FD17F76D" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_39BEAE268F930DA4581D5972FD19A814" xlink:to="loc_us-gaap_StatementTable_909D96EF18FF1B012ED75972FD17F76D" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis" xlink:label="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis_9AB8709BFA3B93FBB18C5972FD173667" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_909D96EF18FF1B012ED75972FD17F76D" xlink:to="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis_9AB8709BFA3B93FBB18C5972FD173667" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain" xlink:label="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_3FB96AE451F1A3396ADC5972FD185B5C_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis_9AB8709BFA3B93FBB18C5972FD173667" xlink:to="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_3FB96AE451F1A3396ADC5972FD185B5C_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain" xlink:label="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_3FB96AE451F1A3396ADC5972FD185B5C" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis_9AB8709BFA3B93FBB18C5972FD173667" xlink:to="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_3FB96AE451F1A3396ADC5972FD185B5C" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_ElancoAnimalHealthIncorporatedMember" xlink:label="loc_lly_ElancoAnimalHealthIncorporatedMember_6AF1014D68A74CB840465972FD186A10" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_3FB96AE451F1A3396ADC5972FD185B5C" xlink:to="loc_lly_ElancoAnimalHealthIncorporatedMember_6AF1014D68A74CB840465972FD186A10" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_LegacyAntibioticMedicinesAndAManufacturingFacilityInSuzhouChinaMember" xlink:label="loc_lly_LegacyAntibioticMedicinesAndAManufacturingFacilityInSuzhouChinaMember_3F3C919A55685B86F8545972FD18CDA2" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_3FB96AE451F1A3396ADC5972FD185B5C" xlink:to="loc_lly_LegacyAntibioticMedicinesAndAManufacturingFacilityInSuzhouChinaMember_3F3C919A55685B86F8545972FD18CDA2" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DisposalGroupClassificationAxis" xlink:label="loc_us-gaap_DisposalGroupClassificationAxis_14938F1ABE1F0445FBD65972FD195BBE" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_909D96EF18FF1B012ED75972FD17F76D" xlink:to="loc_us-gaap_DisposalGroupClassificationAxis_14938F1ABE1F0445FBD65972FD195BBE" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DisposalGroupClassificationDomain" xlink:label="loc_us-gaap_DisposalGroupClassificationDomain_5C875BA090E696E697A55972FD1976C2_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DisposalGroupClassificationAxis_14938F1ABE1F0445FBD65972FD195BBE" xlink:to="loc_us-gaap_DisposalGroupClassificationDomain_5C875BA090E696E697A55972FD1976C2_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DisposalGroupClassificationDomain" xlink:label="loc_us-gaap_DisposalGroupClassificationDomain_5C875BA090E696E697A55972FD1976C2" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DisposalGroupClassificationAxis_14938F1ABE1F0445FBD65972FD195BBE" xlink:to="loc_us-gaap_DisposalGroupClassificationDomain_5C875BA090E696E697A55972FD1976C2" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DisposalGroupDisposedOfBySaleNotDiscontinuedOperationsMember" xlink:label="loc_us-gaap_DisposalGroupDisposedOfBySaleNotDiscontinuedOperationsMember_A5054248A1A05D9D76D35972FD19D6F3" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DisposalGroupClassificationDomain_5C875BA090E696E697A55972FD1976C2" xlink:to="loc_us-gaap_DisposalGroupDisposedOfBySaleNotDiscontinuedOperationsMember_A5054248A1A05D9D76D35972FD19D6F3" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CashAndCashEquivalentsPeriodIncreaseDecreaseAbstract" xlink:label="loc_us-gaap_CashAndCashEquivalentsPeriodIncreaseDecreaseAbstract_4F99BD1465EEDF5EF0465972FD1AE6DF" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_39BEAE268F930DA4581D5972FD19A814" xlink:to="loc_us-gaap_CashAndCashEquivalentsPeriodIncreaseDecreaseAbstract_4F99BD1465EEDF5EF0465972FD1AE6DF" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_3686DEBA4734F5B3A7185972FD1ACEFC" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CashAndCashEquivalentsPeriodIncreaseDecreaseAbstract_4F99BD1465EEDF5EF0465972FD1AE6DF" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_3686DEBA4734F5B3A7185972FD1ACEFC" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NetIncomeLoss" xlink:label="loc_us-gaap_NetIncomeLoss_543E219B36608221F1D45972FD1A6FDB" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_3686DEBA4734F5B3A7185972FD1ACEFC" xlink:to="loc_us-gaap_NetIncomeLoss_543E219B36608221F1D45972FD1A6FDB" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract" xlink:label="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_82B92740DBCEEFC5CD725972FD1B3CC7" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_3686DEBA4734F5B3A7185972FD1ACEFC" xlink:to="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_82B92740DBCEEFC5CD725972FD1B3CC7" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DisposalGroupNotDiscontinuedOperationGainLossOnDisposal" xlink:label="loc_us-gaap_DisposalGroupNotDiscontinuedOperationGainLossOnDisposal_6B59195FBCA3C1E94D465972FD1B34EB" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_82B92740DBCEEFC5CD725972FD1B3CC7" xlink:to="loc_us-gaap_DisposalGroupNotDiscontinuedOperationGainLossOnDisposal_6B59195FBCA3C1E94D465972FD1B34EB" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DepreciationDepletionAndAmortization" xlink:label="loc_us-gaap_DepreciationDepletionAndAmortization_76DDB9B1B43E95556E015972FD1B0020" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_82B92740DBCEEFC5CD725972FD1B3CC7" xlink:to="loc_us-gaap_DepreciationDepletionAndAmortization_76DDB9B1B43E95556E015972FD1B0020" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncreaseDecreaseInDeferredIncomeTaxes" xlink:label="loc_us-gaap_IncreaseDecreaseInDeferredIncomeTaxes_13D1710C47F2F531233D5972FD1BF457" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_82B92740DBCEEFC5CD725972FD1B3CC7" xlink:to="loc_us-gaap_IncreaseDecreaseInDeferredIncomeTaxes_13D1710C47F2F531233D5972FD1BF457" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareBasedCompensation" xlink:label="loc_us-gaap_ShareBasedCompensation_C8EE897F483579D9D2EB5972FD1BAB29" xlink:type="locator" />
    <link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_82B92740DBCEEFC5CD725972FD1B3CC7" xlink:to="loc_us-gaap_ShareBasedCompensation_C8EE897F483579D9D2EB5972FD1BAB29" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_AcquiredInProcessResearchAndDevelopment" xlink:label="loc_lly_AcquiredInProcessResearchAndDevelopment_485B2AE2841EB52119A85972FD1C8177" xlink:type="locator" />
    <link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_82B92740DBCEEFC5CD725972FD1B3CC7" xlink:to="loc_lly_AcquiredInProcessResearchAndDevelopment_485B2AE2841EB52119A85972FD1C8177" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherOperatingActivitiesCashFlowStatement" xlink:label="loc_us-gaap_OtherOperatingActivitiesCashFlowStatement_232DD3D78C98A314BC155972FD1C5844" xlink:type="locator" />
    <link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_82B92740DBCEEFC5CD725972FD1B3CC7" xlink:to="loc_us-gaap_OtherOperatingActivitiesCashFlowStatement_232DD3D78C98A314BC155972FD1C5844" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncreaseDecreaseInOperatingCapitalAbstract" xlink:label="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_FD784A49C202238FE4805972FD1C15DC" xlink:type="locator" />
    <link:definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_82B92740DBCEEFC5CD725972FD1B3CC7" xlink:to="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_FD784A49C202238FE4805972FD1C15DC" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncreaseDecreaseInAccountsAndOtherReceivables" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsAndOtherReceivables_7B2E8ED7E99C7E245E675972FD1C96D6" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_FD784A49C202238FE4805972FD1C15DC" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsAndOtherReceivables_7B2E8ED7E99C7E245E675972FD1C96D6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncreaseDecreaseInInventories" xlink:label="loc_us-gaap_IncreaseDecreaseInInventories_AA6D0E8234B28A8050F05972FD1C4779" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_FD784A49C202238FE4805972FD1C15DC" xlink:to="loc_us-gaap_IncreaseDecreaseInInventories_AA6D0E8234B28A8050F05972FD1C4779" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncreaseDecreaseInOtherOperatingAssets" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherOperatingAssets_DDC18847CFD8EBAFA2F15972FD1C1254" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_FD784A49C202238FE4805972FD1C15DC" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherOperatingAssets_DDC18847CFD8EBAFA2F15972FD1C1254" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncreaseDecreaseInAccruedIncomeTaxesPayable" xlink:label="loc_us-gaap_IncreaseDecreaseInAccruedIncomeTaxesPayable_582DAB6482BADA1E674D5972FD1DDEDA" xlink:type="locator" />
    <link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_FD784A49C202238FE4805972FD1C15DC" xlink:to="loc_us-gaap_IncreaseDecreaseInAccruedIncomeTaxesPayable_582DAB6482BADA1E674D5972FD1DDEDA" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities_5D2D91C4B6C5DA74B0C05972FD1DCDAA" xlink:type="locator" />
    <link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_FD784A49C202238FE4805972FD1C15DC" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities_5D2D91C4B6C5DA74B0C05972FD1DCDAA" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_F15ADE9537AA23447F3B5972FD1D46D5" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_3686DEBA4734F5B3A7185972FD1ACEFC" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_F15ADE9537AA23447F3B5972FD1D46D5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_6986F1D3C1B627E516675972FD1D1687" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CashAndCashEquivalentsPeriodIncreaseDecreaseAbstract_4F99BD1465EEDF5EF0465972FD1AE6DF" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_6986F1D3C1B627E516675972FD1D1687" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PaymentsToAcquireOtherPropertyPlantAndEquipment" xlink:label="loc_us-gaap_PaymentsToAcquireOtherPropertyPlantAndEquipment_0566BA83F16F88DFD17F5972FD1D6D9C" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_6986F1D3C1B627E516675972FD1D1687" xlink:to="loc_us-gaap_PaymentsToAcquireOtherPropertyPlantAndEquipment_0566BA83F16F88DFD17F5972FD1D6D9C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ProceedsFromSaleOfShortTermInvestments" xlink:label="loc_us-gaap_ProceedsFromSaleOfShortTermInvestments_E1CA4C75D86517369A095972FD1EA37B" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_6986F1D3C1B627E516675972FD1D1687" xlink:to="loc_us-gaap_ProceedsFromSaleOfShortTermInvestments_E1CA4C75D86517369A095972FD1EA37B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PaymentsToAcquireShortTermInvestments" xlink:label="loc_us-gaap_PaymentsToAcquireShortTermInvestments_4B85A3D42DF4D63B9B625972FD1E8C4D" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_6986F1D3C1B627E516675972FD1D1687" xlink:to="loc_us-gaap_PaymentsToAcquireShortTermInvestments_4B85A3D42DF4D63B9B625972FD1E8C4D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ProceedsFromSaleAndMaturityOfOtherInvestments" xlink:label="loc_us-gaap_ProceedsFromSaleAndMaturityOfOtherInvestments_B51B881FDD67702516F25972FD1ED6E6" xlink:type="locator" />
    <link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_6986F1D3C1B627E516675972FD1D1687" xlink:to="loc_us-gaap_ProceedsFromSaleAndMaturityOfOtherInvestments_B51B881FDD67702516F25972FD1ED6E6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PaymentsToAcquireOtherInvestments" xlink:label="loc_us-gaap_PaymentsToAcquireOtherInvestments_3341A298200953A3A5095972FD1E18B2" xlink:type="locator" />
    <link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_6986F1D3C1B627E516675972FD1D1687" xlink:to="loc_us-gaap_PaymentsToAcquireOtherInvestments_3341A298200953A3A5095972FD1E18B2" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_PurchasedInProcessResearchAndDevelopment" xlink:label="loc_lly_PurchasedInProcessResearchAndDevelopment_75BDD585C901678414B65972FD1E34F9" xlink:type="locator" />
    <link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_6986F1D3C1B627E516675972FD1D1687" xlink:to="loc_lly_PurchasedInProcessResearchAndDevelopment_75BDD585C901678414B65972FD1E34F9" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired" xlink:label="loc_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_D66F8FC8C8C531A4686F5972FD1E9FE6" xlink:type="locator" />
    <link:definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_6986F1D3C1B627E516675972FD1D1687" xlink:to="loc_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_D66F8FC8C8C531A4686F5972FD1E9FE6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CashDivestedFromDeconsolidation" xlink:label="loc_us-gaap_CashDivestedFromDeconsolidation_D71274942A9D840706EF5972FD1F0063" xlink:type="locator" />
    <link:definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_6986F1D3C1B627E516675972FD1D1687" xlink:to="loc_us-gaap_CashDivestedFromDeconsolidation_D71274942A9D840706EF5972FD1F0063" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ProceedsFromDivestitureOfBusinesses" xlink:label="loc_us-gaap_ProceedsFromDivestitureOfBusinesses_8216AA19D3F81949B72A5972FD1F307E" xlink:type="locator" />
    <link:definitionArc order="9" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_6986F1D3C1B627E516675972FD1D1687" xlink:to="loc_us-gaap_ProceedsFromDivestitureOfBusinesses_8216AA19D3F81949B72A5972FD1F307E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PaymentsForProceedsFromOtherInvestingActivities" xlink:label="loc_us-gaap_PaymentsForProceedsFromOtherInvestingActivities_6761E9227EF25BFAB1F25972FD1F6741" xlink:type="locator" />
    <link:definitionArc order="10" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_6986F1D3C1B627E516675972FD1D1687" xlink:to="loc_us-gaap_PaymentsForProceedsFromOtherInvestingActivities_6761E9227EF25BFAB1F25972FD1F6741" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_98D186CAF26130D568F95972FD1F39F8" xlink:type="locator" />
    <link:definitionArc order="11" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_6986F1D3C1B627E516675972FD1D1687" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_98D186CAF26130D568F95972FD1F39F8" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_BAAC3881ECB3BD8720615972FD1FC0D1" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CashAndCashEquivalentsPeriodIncreaseDecreaseAbstract_4F99BD1465EEDF5EF0465972FD1AE6DF" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_BAAC3881ECB3BD8720615972FD1FC0D1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PaymentsOfDividends" xlink:label="loc_us-gaap_PaymentsOfDividends_EE765B78CF6D19A6779A5972FD1F5310" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_BAAC3881ECB3BD8720615972FD1FC0D1" xlink:to="loc_us-gaap_PaymentsOfDividends_EE765B78CF6D19A6779A5972FD1F5310" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ProceedsFromRepaymentsOfShortTermDebt" xlink:label="loc_us-gaap_ProceedsFromRepaymentsOfShortTermDebt_9E2722F5309C900FCFF05972FD20562C" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_BAAC3881ECB3BD8720615972FD1FC0D1" xlink:to="loc_us-gaap_ProceedsFromRepaymentsOfShortTermDebt_9E2722F5309C900FCFF05972FD20562C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ProceedsFromIssuanceOfLongTermDebt" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfLongTermDebt_6CB5EDFCB27BA27319355972FD20E6A0" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_BAAC3881ECB3BD8720615972FD1FC0D1" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfLongTermDebt_6CB5EDFCB27BA27319355972FD20E6A0" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RepaymentsOfLongTermDebt" xlink:label="loc_us-gaap_RepaymentsOfLongTermDebt_6399360E8E9B3C98843F5972FD20C498" xlink:type="locator" />
    <link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_BAAC3881ECB3BD8720615972FD1FC0D1" xlink:to="loc_us-gaap_RepaymentsOfLongTermDebt_6399360E8E9B3C98843F5972FD20C498" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PaymentsForRepurchaseOfCommonStock" xlink:label="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_26ECB826CD6E863CF41B5972FD200C52" xlink:type="locator" />
    <link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_BAAC3881ECB3BD8720615972FD1FC0D1" xlink:to="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_26ECB826CD6E863CF41B5972FD200C52" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_ProceedsfromIssuanceorSaleofEquityfromSubsidiary" xlink:label="loc_lly_ProceedsfromIssuanceorSaleofEquityfromSubsidiary_417ED09FCC055F98E4D55972FD2006BD" xlink:type="locator" />
    <link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_BAAC3881ECB3BD8720615972FD1FC0D1" xlink:to="loc_lly_ProceedsfromIssuanceorSaleofEquityfromSubsidiary_417ED09FCC055F98E4D55972FD2006BD" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ProceedsFromPaymentsForOtherFinancingActivities" xlink:label="loc_us-gaap_ProceedsFromPaymentsForOtherFinancingActivities_CCEA7C478B37026AF1805972FD2026CC" xlink:type="locator" />
    <link:definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_BAAC3881ECB3BD8720615972FD1FC0D1" xlink:to="loc_us-gaap_ProceedsFromPaymentsForOtherFinancingActivities_CCEA7C478B37026AF1805972FD2026CC" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_D489BD8FCD820FB25EB75972FD21645D" xlink:type="locator" />
    <link:definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_BAAC3881ECB3BD8720615972FD1FC0D1" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_D489BD8FCD820FB25EB75972FD21645D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EffectOfExchangeRateOnCashAndCashEquivalents" xlink:label="loc_us-gaap_EffectOfExchangeRateOnCashAndCashEquivalents_C1A181348AAA7B81A22D5972FD2170CB" xlink:type="locator" />
    <link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CashAndCashEquivalentsPeriodIncreaseDecreaseAbstract_4F99BD1465EEDF5EF0465972FD1AE6DF" xlink:to="loc_us-gaap_EffectOfExchangeRateOnCashAndCashEquivalents_C1A181348AAA7B81A22D5972FD2170CB" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CashAndCashEquivalentsPeriodIncreaseDecrease" xlink:label="loc_us-gaap_CashAndCashEquivalentsPeriodIncreaseDecrease_DAF74728912F1F85F9355972FD21720F" xlink:type="locator" />
    <link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CashAndCashEquivalentsPeriodIncreaseDecreaseAbstract_4F99BD1465EEDF5EF0465972FD1AE6DF" xlink:to="loc_us-gaap_CashAndCashEquivalentsPeriodIncreaseDecrease_DAF74728912F1F85F9355972FD21720F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValueIncludingDiscontinuedOperations" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValueIncludingDiscontinuedOperations_EA2BAB0BEFEE7E9F4A645972FD21F1ED" xlink:type="locator" />
    <link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CashAndCashEquivalentsPeriodIncreaseDecreaseAbstract_4F99BD1465EEDF5EF0465972FD1AE6DF" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValueIncludingDiscontinuedOperations_EA2BAB0BEFEE7E9F4A645972FD21F1ED" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_71E2C39937AEDC4360D75972FD217B59" xlink:type="locator" />
    <link:definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CashAndCashEquivalentsPeriodIncreaseDecreaseAbstract_4F99BD1465EEDF5EF0465972FD1AE6DF" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_71E2C39937AEDC4360D75972FD217B59" xlink:type="arc" />
  </link:definitionLink>
  <link:definitionLink xlink:role="http://www.lilly.com/role/ConsolidatedStatementsOfCashFlowsParenthetical" xlink:type="extended" />
  <link:definitionLink xlink:role="http://www.lilly.com/role/ConsolidatedStatementsOfComprehensiveIncomeLoss" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_EA2030B84CEBBBEF6B7E3B9CB4EAF00E" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementTable" xlink:label="loc_us-gaap_StatementTable_92F46EF5CCFA94A095203B9CB4E800CD" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_EA2030B84CEBBBEF6B7E3B9CB4EAF00E" xlink:to="loc_us-gaap_StatementTable_92F46EF5CCFA94A095203B9CB4E800CD" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementOperatingActivitiesSegmentAxis" xlink:label="loc_us-gaap_StatementOperatingActivitiesSegmentAxis_245563512DB90012412E3B9CB4E8FF10" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_92F46EF5CCFA94A095203B9CB4E800CD" xlink:to="loc_us-gaap_StatementOperatingActivitiesSegmentAxis_245563512DB90012412E3B9CB4E8FF10" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SegmentOperatingActivitiesDomain" xlink:label="loc_us-gaap_SegmentOperatingActivitiesDomain_E7942E9511EE22F666403B9CB4E90BE2_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementOperatingActivitiesSegmentAxis_245563512DB90012412E3B9CB4E8FF10" xlink:to="loc_us-gaap_SegmentOperatingActivitiesDomain_E7942E9511EE22F666403B9CB4E90BE2_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SegmentOperatingActivitiesDomain" xlink:label="loc_us-gaap_SegmentOperatingActivitiesDomain_E7942E9511EE22F666403B9CB4E90BE2" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementOperatingActivitiesSegmentAxis_245563512DB90012412E3B9CB4E8FF10" xlink:to="loc_us-gaap_SegmentOperatingActivitiesDomain_E7942E9511EE22F666403B9CB4E90BE2" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SegmentContinuingOperationsMember" xlink:label="loc_us-gaap_SegmentContinuingOperationsMember_F7CCD0591F6C90E98EA23B9CB4E9A762" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentOperatingActivitiesDomain_E7942E9511EE22F666403B9CB4E90BE2" xlink:to="loc_us-gaap_SegmentContinuingOperationsMember_F7CCD0591F6C90E98EA23B9CB4E9A762" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SegmentDiscontinuedOperationsMember" xlink:label="loc_us-gaap_SegmentDiscontinuedOperationsMember_928294FFA71EF439F9603B9CB4EA63EA" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentOperatingActivitiesDomain_E7942E9511EE22F666403B9CB4E90BE2" xlink:to="loc_us-gaap_SegmentDiscontinuedOperationsMember_928294FFA71EF439F9603B9CB4EA63EA" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NetIncomeLoss" xlink:label="loc_us-gaap_NetIncomeLoss_403E0632E6D57B47B0633B9CB4EAB25F" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_EA2030B84CEBBBEF6B7E3B9CB4EAF00E" xlink:to="loc_us-gaap_NetIncomeLoss_403E0632E6D57B47B0633B9CB4EAB25F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossBeforeTaxPeriodIncreaseDecreaseAbstract" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossBeforeTaxPeriodIncreaseDecreaseAbstract_8F4868947F476C576B7B3B9CB4EA3519" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_EA2030B84CEBBBEF6B7E3B9CB4EAF00E" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossBeforeTaxPeriodIncreaseDecreaseAbstract_8F4868947F476C576B7B3B9CB4EA3519" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationGainLossBeforeReclassificationAndTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationGainLossBeforeReclassificationAndTax_D739420EF9B8E8FC81BB3B9CB4ECF6C9" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossBeforeTaxPeriodIncreaseDecreaseAbstract_8F4868947F476C576B7B3B9CB4EA3519" xlink:to="loc_us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationGainLossBeforeReclassificationAndTax_D739420EF9B8E8FC81BB3B9CB4ECF6C9" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentBeforeTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentBeforeTax_E1EB3EFA46DDBB10E82A3B9CB4EDBD8C" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossBeforeTaxPeriodIncreaseDecreaseAbstract_8F4868947F476C576B7B3B9CB4EA3519" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentBeforeTax_E1EB3EFA46DDBB10E82A3B9CB4EDBD8C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansAdjustmentBeforeTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansAdjustmentBeforeTax_D6380D7E7A54F71D85003B9CB4EDDCA5" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossBeforeTaxPeriodIncreaseDecreaseAbstract_8F4868947F476C576B7B3B9CB4EA3519" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansAdjustmentBeforeTax_D6380D7E7A54F71D85003B9CB4EDDCA5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationBeforeTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationBeforeTax_24CD2321517860FF31503B9CB4EDAA6E" xlink:type="locator" />
    <link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossBeforeTaxPeriodIncreaseDecreaseAbstract_8F4868947F476C576B7B3B9CB4EA3519" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationBeforeTax_24CD2321517860FF31503B9CB4EDAA6E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossDerivativesQualifyingAsHedgesBeforeTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossDerivativesQualifyingAsHedgesBeforeTax_4E07041F214AAB4648583B9CB4ED6DB5" xlink:type="locator" />
    <link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossBeforeTaxPeriodIncreaseDecreaseAbstract_8F4868947F476C576B7B3B9CB4EA3519" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossDerivativesQualifyingAsHedgesBeforeTax_4E07041F214AAB4648583B9CB4ED6DB5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossBeforeTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossBeforeTax_5A0548C1D63B480EE6813B9CB4EEBD48" xlink:type="locator" />
    <link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossBeforeTaxPeriodIncreaseDecreaseAbstract_8F4868947F476C576B7B3B9CB4EA3519" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossBeforeTax_5A0548C1D63B480EE6813B9CB4EEBD48" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossTax_E12A9D44C571A0F085313B9CB4EE14DE" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_EA2030B84CEBBBEF6B7E3B9CB4EAF00E" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossTax_E12A9D44C571A0F085313B9CB4EE14DE" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_864EBED0D9C5FC24D6743B9CB4EE5D63" xlink:type="locator" />
    <link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_EA2030B84CEBBBEF6B7E3B9CB4EAF00E" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_864EBED0D9C5FC24D6743B9CB4EE5D63" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ComprehensiveIncomeNetOfTaxIncludingPortionAttributableToNoncontrollingInterest" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTaxIncludingPortionAttributableToNoncontrollingInterest_3CF31D39610493F3E6BD3B9CB4EEB38D" xlink:type="locator" />
    <link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_EA2030B84CEBBBEF6B7E3B9CB4EAF00E" xlink:to="loc_us-gaap_ComprehensiveIncomeNetOfTaxIncludingPortionAttributableToNoncontrollingInterest_3CF31D39610493F3E6BD3B9CB4EEB38D" xlink:type="arc" />
  </link:definitionLink>
  <link:definitionLink xlink:role="http://www.lilly.com/role/ConsolidatedStatementsOfOperations" xlink:type="extended" />
  <link:definitionLink xlink:role="http://www.lilly.com/role/ConsolidatedStatementsOfShareholdersEquityParenthetical" xlink:type="extended" />
  <link:definitionLink xlink:role="http://www.lilly.com/role/ConsolidatedStatementsOfShareholdersEquityStatement" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_9550C01E6A0444CF1CC93BA23E436FE5" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementTable" xlink:label="loc_us-gaap_StatementTable_6826AA0AC8BD3A25BC0C3BA23E41D4F2" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_9550C01E6A0444CF1CC93BA23E436FE5" xlink:to="loc_us-gaap_StatementTable_6826AA0AC8BD3A25BC0C3BA23E41D4F2" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementEquityComponentsAxis" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_5B625BF1280A2C1CB20E3BA23E4141B1" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_6826AA0AC8BD3A25BC0C3BA23E41D4F2" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_5B625BF1280A2C1CB20E3BA23E4141B1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EquityComponentDomain" xlink:label="loc_us-gaap_EquityComponentDomain_8DDBDBCFF74B7056C2233BA23E42D29D_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_5B625BF1280A2C1CB20E3BA23E4141B1" xlink:to="loc_us-gaap_EquityComponentDomain_8DDBDBCFF74B7056C2233BA23E42D29D_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EquityComponentDomain" xlink:label="loc_us-gaap_EquityComponentDomain_8DDBDBCFF74B7056C2233BA23E42D29D" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_5B625BF1280A2C1CB20E3BA23E4141B1" xlink:to="loc_us-gaap_EquityComponentDomain_8DDBDBCFF74B7056C2233BA23E42D29D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CommonStockMember" xlink:label="loc_us-gaap_CommonStockMember_90554637C156A888EB1B3BA23E421A74" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_8DDBDBCFF74B7056C2233BA23E42D29D" xlink:to="loc_us-gaap_CommonStockMember_90554637C156A888EB1B3BA23E421A74" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AdditionalPaidInCapitalMember" xlink:label="loc_us-gaap_AdditionalPaidInCapitalMember_E3E03B6968C8AF80DD7F3BA23E4290AC" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_8DDBDBCFF74B7056C2233BA23E42D29D" xlink:to="loc_us-gaap_AdditionalPaidInCapitalMember_E3E03B6968C8AF80DD7F3BA23E4290AC" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RetainedEarningsMember" xlink:label="loc_us-gaap_RetainedEarningsMember_F116B0F1146E29CA10A53BA23E42927D" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_8DDBDBCFF74B7056C2233BA23E42D29D" xlink:to="loc_us-gaap_RetainedEarningsMember_F116B0F1146E29CA10A53BA23E42927D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_TrustForBenefitOfEmployeesMember" xlink:label="loc_us-gaap_TrustForBenefitOfEmployeesMember_FA73335CC40BB1FBAD313BA23E439886" xlink:type="locator" />
    <link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_8DDBDBCFF74B7056C2233BA23E42D29D" xlink:to="loc_us-gaap_TrustForBenefitOfEmployeesMember_FA73335CC40BB1FBAD313BA23E439886" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeMember" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_B5B8D8F71AA735DE30633BA23E432DAD" xlink:type="locator" />
    <link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_8DDBDBCFF74B7056C2233BA23E42D29D" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_B5B8D8F71AA735DE30633BA23E432DAD" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_TreasuryStockMember" xlink:label="loc_us-gaap_TreasuryStockMember_23660D1966931125AAE23BA23E430A3C" xlink:type="locator" />
    <link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_8DDBDBCFF74B7056C2233BA23E42D29D" xlink:to="loc_us-gaap_TreasuryStockMember_23660D1966931125AAE23BA23E430A3C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NoncontrollingInterestMember" xlink:label="loc_us-gaap_NoncontrollingInterestMember_93063A90CF3196C864203BA23E433A8C" xlink:type="locator" />
    <link:definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_8DDBDBCFF74B7056C2233BA23E42D29D" xlink:to="loc_us-gaap_NoncontrollingInterestMember_93063A90CF3196C864203BA23E433A8C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncreaseDecreaseInStockholdersEquityRollForward" xlink:label="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_4CEFFD7024AA3657313D3BA23E43A198" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_9550C01E6A0444CF1CC93BA23E436FE5" xlink:to="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_4CEFFD7024AA3657313D3BA23E43A198" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SharesIssued" xlink:label="loc_us-gaap_SharesIssued_8AF2C244F9378202DC873BA23E4457D2" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_4CEFFD7024AA3657313D3BA23E43A198" xlink:to="loc_us-gaap_SharesIssued_8AF2C244F9378202DC873BA23E4457D2" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_D767A321A04C2F4B16C63BA23E44C057" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_4CEFFD7024AA3657313D3BA23E43A198" xlink:to="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_D767A321A04C2F4B16C63BA23E44C057" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ProfitLoss" xlink:label="loc_us-gaap_ProfitLoss_C33DA4F5E2824B5F80803BA23E445DA7" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_4CEFFD7024AA3657313D3BA23E43A198" xlink:to="loc_us-gaap_ProfitLoss_C33DA4F5E2824B5F80803BA23E445DA7" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_5D8F3E4EB3A1C6A2AA013BA23E4412CD" xlink:type="locator" />
    <link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_4CEFFD7024AA3657313D3BA23E43A198" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_5D8F3E4EB3A1C6A2AA013BA23E4412CD" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_Dividends" xlink:label="loc_us-gaap_Dividends_BAEAB761A5A23914D14D3BA23E457BFE" xlink:type="locator" />
    <link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_4CEFFD7024AA3657313D3BA23E43A198" xlink:to="loc_us-gaap_Dividends_BAEAB761A5A23914D14D3BA23E457BFE" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_TreasuryStockSharesRetired" xlink:label="loc_us-gaap_TreasuryStockSharesRetired_4E2045F922D82E35FDC03BA23E459FE1" xlink:type="locator" />
    <link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_4CEFFD7024AA3657313D3BA23E43A198" xlink:to="loc_us-gaap_TreasuryStockSharesRetired_4E2045F922D82E35FDC03BA23E459FE1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_TreasuryStockRetiredCostMethodAmount" xlink:label="loc_us-gaap_TreasuryStockRetiredCostMethodAmount_29FF1F683A67FE5CC7473BA23E45140F" xlink:type="locator" />
    <link:definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_4CEFFD7024AA3657313D3BA23E43A198" xlink:to="loc_us-gaap_TreasuryStockRetiredCostMethodAmount_29FF1F683A67FE5CC7473BA23E45140F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_TreasuryStockValueAcquiredCostMethod" xlink:label="loc_us-gaap_TreasuryStockValueAcquiredCostMethod_A9B51D48A41E947439723BA23E45CDE9" xlink:type="locator" />
    <link:definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_4CEFFD7024AA3657313D3BA23E43A198" xlink:to="loc_us-gaap_TreasuryStockValueAcquiredCostMethod_A9B51D48A41E947439723BA23E45CDE9" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_TreasuryStockSharesAcquired" xlink:label="loc_us-gaap_TreasuryStockSharesAcquired_9A272FA8CE2F49A3622F3BA23E452245" xlink:type="locator" />
    <link:definitionArc order="9" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_4CEFFD7024AA3657313D3BA23E43A198" xlink:to="loc_us-gaap_TreasuryStockSharesAcquired_9A272FA8CE2F49A3622F3BA23E452245" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesEmployeeStockPurchasePlans" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesEmployeeStockPurchasePlans_84073AEF8C4B0F74A96D3BA23E45E799" xlink:type="locator" />
    <link:definitionArc order="10" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_4CEFFD7024AA3657313D3BA23E43A198" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesEmployeeStockPurchasePlans_84073AEF8C4B0F74A96D3BA23E45E799" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueEmployeeStockPurchasePlan" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueEmployeeStockPurchasePlan_FCBBFDD0F11E5D6E23C53BA23E453431" xlink:type="locator" />
    <link:definitionArc order="11" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_4CEFFD7024AA3657313D3BA23E43A198" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueEmployeeStockPurchasePlan_FCBBFDD0F11E5D6E23C53BA23E453431" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueShareBasedCompensation" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueShareBasedCompensation_819FAA24F13ECC26D6F13BA23E46B8EB" xlink:type="locator" />
    <link:definitionArc order="12" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_4CEFFD7024AA3657313D3BA23E43A198" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueShareBasedCompensation_819FAA24F13ECC26D6F13BA23E46B8EB" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_TaxCutsAndJobsActOf2017ReclassificationFromAociToRetainedEarningsTaxEffect" xlink:label="loc_us-gaap_TaxCutsAndJobsActOf2017ReclassificationFromAociToRetainedEarningsTaxEffect_FEC0094038D5346222CF3BA23E464C29" xlink:type="locator" />
    <link:definitionArc order="13" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_4CEFFD7024AA3657313D3BA23E43A198" xlink:to="loc_us-gaap_TaxCutsAndJobsActOf2017ReclassificationFromAociToRetainedEarningsTaxEffect_FEC0094038D5346222CF3BA23E464C29" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CumulativeEffectOfNewAccountingPrincipleInPeriodOfAdoption" xlink:label="loc_us-gaap_CumulativeEffectOfNewAccountingPrincipleInPeriodOfAdoption_E0528CF524C5595CAA1C3BA23E46E5A0" xlink:type="locator" />
    <link:definitionArc order="14" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_4CEFFD7024AA3657313D3BA23E43A198" xlink:to="loc_us-gaap_CumulativeEffectOfNewAccountingPrincipleInPeriodOfAdoption_E0528CF524C5595CAA1C3BA23E46E5A0" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueNewIssues" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueNewIssues_3E3941EB2160528B98393BB712833251" xlink:type="locator" />
    <link:definitionArc order="15" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_4CEFFD7024AA3657313D3BA23E43A198" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueNewIssues_3E3941EB2160528B98393BB712833251" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_StockAcquiredDuringPeriodSharesExchangeOffer" xlink:label="loc_lly_StockAcquiredDuringPeriodSharesExchangeOffer_3D501291811EF95571E53BA23E46A222" xlink:type="locator" />
    <link:definitionArc order="16" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_4CEFFD7024AA3657313D3BA23E43A198" xlink:to="loc_lly_StockAcquiredDuringPeriodSharesExchangeOffer_3D501291811EF95571E53BA23E46A222" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_StockAcquiredDuringPeriodValueExchangeOffer" xlink:label="loc_lly_StockAcquiredDuringPeriodValueExchangeOffer_9C29070A71AB158560B33BA23E46C86F" xlink:type="locator" />
    <link:definitionArc order="17" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_4CEFFD7024AA3657313D3BA23E43A198" xlink:to="loc_lly_StockAcquiredDuringPeriodValueExchangeOffer_9C29070A71AB158560B33BA23E46C86F" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_ImpactonEquityofSaleofNoncontrollingInterestinSubsidiary" xlink:label="loc_lly_ImpactonEquityofSaleofNoncontrollingInterestinSubsidiary_843103E5DA31FF0A5F9E3BA23E4698C6" xlink:type="locator" />
    <link:definitionArc order="18" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_4CEFFD7024AA3657313D3BA23E43A198" xlink:to="loc_lly_ImpactonEquityofSaleofNoncontrollingInterestinSubsidiary_843103E5DA31FF0A5F9E3BA23E4698C6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StockholdersEquityOther" xlink:label="loc_us-gaap_StockholdersEquityOther_7CC0FFC538A257D12F613BA23E475BE3" xlink:type="locator" />
    <link:definitionArc order="19" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_4CEFFD7024AA3657313D3BA23E43A198" xlink:to="loc_us-gaap_StockholdersEquityOther_7CC0FFC538A257D12F613BA23E475BE3" xlink:type="arc" />
  </link:definitionLink>
  <link:definitionLink xlink:role="http://www.lilly.com/role/Contingencies" xlink:type="extended" />
  <link:definitionLink xlink:role="http://www.lilly.com/role/ContingenciesDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LossContingenciesLineItems" xlink:label="loc_us-gaap_LossContingenciesLineItems_DCA11E14DE5BD87EEE915E4E03CC3887" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LossContingenciesTable" xlink:label="loc_us-gaap_LossContingenciesTable_4A51FDA79C43F102BC755E4E03C9398D" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_LossContingenciesLineItems_DCA11E14DE5BD87EEE915E4E03CC3887" xlink:to="loc_us-gaap_LossContingenciesTable_4A51FDA79C43F102BC755E4E03C9398D" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_StatementScenarioAxis" xlink:label="loc_srt_StatementScenarioAxis_C2FA234E63220A2CC8F65E57BC1876C5" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_LossContingenciesTable_4A51FDA79C43F102BC755E4E03C9398D" xlink:to="loc_srt_StatementScenarioAxis_C2FA234E63220A2CC8F65E57BC1876C5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_ScenarioUnspecifiedDomain" xlink:label="loc_srt_ScenarioUnspecifiedDomain_2DCD876331D3F81403E15E57BC1A3333_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_StatementScenarioAxis_C2FA234E63220A2CC8F65E57BC1876C5" xlink:to="loc_srt_ScenarioUnspecifiedDomain_2DCD876331D3F81403E15E57BC1A3333_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_ScenarioUnspecifiedDomain" xlink:label="loc_srt_ScenarioUnspecifiedDomain_2DCD876331D3F81403E15E57BC1A3333" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_StatementScenarioAxis_C2FA234E63220A2CC8F65E57BC1876C5" xlink:to="loc_srt_ScenarioUnspecifiedDomain_2DCD876331D3F81403E15E57BC1A3333" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_ScenarioForecastMember" xlink:label="loc_srt_ScenarioForecastMember_13A760EE4BAB33ED48325E57D0CCB8F3" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ScenarioUnspecifiedDomain_2DCD876331D3F81403E15E57BC1A3333" xlink:to="loc_srt_ScenarioForecastMember_13A760EE4BAB33ED48325E57D0CCB8F3" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SubsequentEventTypeAxis" xlink:label="loc_us-gaap_SubsequentEventTypeAxis_291B8BC012A52A05D6565E56F3CC866D" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_LossContingenciesTable_4A51FDA79C43F102BC755E4E03C9398D" xlink:to="loc_us-gaap_SubsequentEventTypeAxis_291B8BC012A52A05D6565E56F3CC866D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SubsequentEventTypeDomain" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_2B6B28C6ED47FBB7C9E15E56F3D0EC93_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_291B8BC012A52A05D6565E56F3CC866D" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_2B6B28C6ED47FBB7C9E15E56F3D0EC93_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SubsequentEventTypeDomain" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_2B6B28C6ED47FBB7C9E15E56F3D0EC93" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_291B8BC012A52A05D6565E56F3CC866D" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_2B6B28C6ED47FBB7C9E15E56F3D0EC93" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SubsequentEventMember" xlink:label="loc_us-gaap_SubsequentEventMember_347458956B3B97479A685E57080A649E" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsequentEventTypeDomain_2B6B28C6ED47FBB7C9E15E56F3D0EC93" xlink:to="loc_us-gaap_SubsequentEventMember_347458956B3B97479A685E57080A649E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_StatementGeographicalAxis" xlink:label="loc_srt_StatementGeographicalAxis_838F2E498A5B4A99A9E75E4E03C94CB2" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_LossContingenciesTable_4A51FDA79C43F102BC755E4E03C9398D" xlink:to="loc_srt_StatementGeographicalAxis_838F2E498A5B4A99A9E75E4E03C94CB2" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_SegmentGeographicalDomain" xlink:label="loc_srt_SegmentGeographicalDomain_F9CE2F2EDBA1E0B93E315E4E03CA36EF_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_StatementGeographicalAxis_838F2E498A5B4A99A9E75E4E03C94CB2" xlink:to="loc_srt_SegmentGeographicalDomain_F9CE2F2EDBA1E0B93E315E4E03CA36EF_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_SegmentGeographicalDomain" xlink:label="loc_srt_SegmentGeographicalDomain_F9CE2F2EDBA1E0B93E315E4E03CA36EF" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_StatementGeographicalAxis_838F2E498A5B4A99A9E75E4E03C94CB2" xlink:to="loc_srt_SegmentGeographicalDomain_F9CE2F2EDBA1E0B93E315E4E03CA36EF" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/country/2017/country-2017-01-31.xsd#country_BR" xlink:label="loc_country_BR_2102DCFDB6E65EB6E65B5E4E03CAAE0D" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_F9CE2F2EDBA1E0B93E315E4E03CA36EF" xlink:to="loc_country_BR_2102DCFDB6E65EB6E65B5E4E03CAAE0D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_LitigationCaseAxis" xlink:label="loc_srt_LitigationCaseAxis_6B8B186F5F41F4681F5F5E4E03CABA99" xlink:type="locator" />
    <link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_LossContingenciesTable_4A51FDA79C43F102BC755E4E03C9398D" xlink:to="loc_srt_LitigationCaseAxis_6B8B186F5F41F4681F5F5E4E03CABA99" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_LitigationCaseTypeDomain" xlink:label="loc_srt_LitigationCaseTypeDomain_5CDCF7E8139BABA596285E4E03CBB807_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_LitigationCaseAxis_6B8B186F5F41F4681F5F5E4E03CABA99" xlink:to="loc_srt_LitigationCaseTypeDomain_5CDCF7E8139BABA596285E4E03CBB807_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_LitigationCaseTypeDomain" xlink:label="loc_srt_LitigationCaseTypeDomain_5CDCF7E8139BABA596285E4E03CBB807" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_LitigationCaseAxis_6B8B186F5F41F4681F5F5E4E03CABA99" xlink:to="loc_srt_LitigationCaseTypeDomain_5CDCF7E8139BABA596285E4E03CBB807" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_DrReddysLabMember" xlink:label="loc_lly_DrReddysLabMember_091A06CB8BCE37DA0D795E4E03CB50C1" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_LitigationCaseTypeDomain_5CDCF7E8139BABA596285E4E03CBB807" xlink:to="loc_lly_DrReddysLabMember_091A06CB8BCE37DA0D795E4E03CB50C1" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_JapaneseAdministrativeProceedingsMember" xlink:label="loc_lly_JapaneseAdministrativeProceedingsMember_E0CEF484C6D33032B1175E4E03CB8F90" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_LitigationCaseTypeDomain_5CDCF7E8139BABA596285E4E03CBB807" xlink:to="loc_lly_JapaneseAdministrativeProceedingsMember_E0CEF484C6D33032B1175E4E03CB8F90" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_EmgalityPatentLitigationMember" xlink:label="loc_lly_EmgalityPatentLitigationMember_F8745F26F061FDE9DB895E4E03CC074B" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_LitigationCaseTypeDomain_5CDCF7E8139BABA596285E4E03CBB807" xlink:to="loc_lly_EmgalityPatentLitigationMember_F8745F26F061FDE9DB895E4E03CC074B" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_EmployeeLitigationMember" xlink:label="loc_lly_EmployeeLitigationMember_CF81A4525E4AF437B1B95E4E03CC17A0" xlink:type="locator" />
    <link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_LitigationCaseTypeDomain_5CDCF7E8139BABA596285E4E03CBB807" xlink:to="loc_lly_EmployeeLitigationMember_CF81A4525E4AF437B1B95E4E03CC17A0" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_InsulinPricingLitigationAndProceedingsHouseOfRepresentativesCommitteeOnEnergyAndCommerceMember" xlink:label="loc_lly_InsulinPricingLitigationAndProceedingsHouseOfRepresentativesCommitteeOnEnergyAndCommerceMember_ADFDF77E738D6BE5FDB15E4E03CCFE5E" xlink:type="locator" />
    <link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_LitigationCaseTypeDomain_5CDCF7E8139BABA596285E4E03CBB807" xlink:to="loc_lly_InsulinPricingLitigationAndProceedingsHouseOfRepresentativesCommitteeOnEnergyAndCommerceMember_ADFDF77E738D6BE5FDB15E4E03CCFE5E" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_LossContingencyClaimsSettledAndDismissedLimitedInitialMarketEntrySupplyTerm" xlink:label="loc_lly_LossContingencyClaimsSettledAndDismissedLimitedInitialMarketEntrySupplyTerm_11C4D3F288A272DD4EA25E4E03CD78A4" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_DCA11E14DE5BD87EEE915E4E03CC3887" xlink:to="loc_lly_LossContingencyClaimsSettledAndDismissedLimitedInitialMarketEntrySupplyTerm_11C4D3F288A272DD4EA25E4E03CD78A4" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LossContingencyClaimsSettledAndDismissedNumber" xlink:label="loc_us-gaap_LossContingencyClaimsSettledAndDismissedNumber_E81D20CF21308B734C485E4E03CDF7FB" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_DCA11E14DE5BD87EEE915E4E03CC3887" xlink:to="loc_us-gaap_LossContingencyClaimsSettledAndDismissedNumber_E81D20CF21308B734C485E4E03CDF7FB" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_LossContingencyNumberofDemands" xlink:label="loc_lly_LossContingencyNumberofDemands_163332E07DA04E1B09445E4E03CD1947" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_DCA11E14DE5BD87EEE915E4E03CC3887" xlink:to="loc_lly_LossContingencyNumberofDemands_163332E07DA04E1B09445E4E03CD1947" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_LossContingencyNumberOfPatents" xlink:label="loc_lly_LossContingencyNumberOfPatents_55F7CEBA09B8A638C1515E4E03CDA8B4" xlink:type="locator" />
    <link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_DCA11E14DE5BD87EEE915E4E03CC3887" xlink:to="loc_lly_LossContingencyNumberOfPatents_55F7CEBA09B8A638C1515E4E03CDA8B4" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_LossContingencyNumberOfPatentsClaimsDismissed" xlink:label="loc_lly_LossContingencyNumberOfPatentsClaimsDismissed_28314565D7A2B9D632F95E564B87B557" xlink:type="locator" />
    <link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_DCA11E14DE5BD87EEE915E4E03CC3887" xlink:to="loc_lly_LossContingencyNumberOfPatentsClaimsDismissed_28314565D7A2B9D632F95E564B87B557" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_LossContingencyNumberOfPatentsClaimsDecisionExpected" xlink:label="loc_lly_LossContingencyNumberOfPatentsClaimsDecisionExpected_27F0C283438436DC22905E596FB2E84F" xlink:type="locator" />
    <link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_DCA11E14DE5BD87EEE915E4E03CC3887" xlink:to="loc_lly_LossContingencyNumberOfPatentsClaimsDecisionExpected_27F0C283438436DC22905E596FB2E84F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LossContingencyDamagesAwardedValue" xlink:label="loc_us-gaap_LossContingencyDamagesAwardedValue_38F1EB6470CEDD83A4C75E4E03CDBFEC" xlink:type="locator" />
    <link:definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_DCA11E14DE5BD87EEE915E4E03CC3887" xlink:to="loc_us-gaap_LossContingencyDamagesAwardedValue_38F1EB6470CEDD83A4C75E4E03CDBFEC" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_LossContingencyNumberOfLawsuits" xlink:label="loc_lly_LossContingencyNumberOfLawsuits_F72A694D92BAA72BE4D55E4E03CE5FFE" xlink:type="locator" />
    <link:definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_DCA11E14DE5BD87EEE915E4E03CC3887" xlink:to="loc_lly_LossContingencyNumberOfLawsuits_F72A694D92BAA72BE4D55E4E03CE5FFE" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_LossContingencyNumberOfRequestsForInformation" xlink:label="loc_lly_LossContingencyNumberOfRequestsForInformation_D273D7721E68A293677F5E4E03CED860" xlink:type="locator" />
    <link:definitionArc order="9" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_DCA11E14DE5BD87EEE915E4E03CC3887" xlink:to="loc_lly_LossContingencyNumberOfRequestsForInformation_D273D7721E68A293677F5E4E03CED860" xlink:type="arc" />
  </link:definitionLink>
  <link:definitionLink xlink:role="http://www.lilly.com/role/ContingenciesPolicies" xlink:type="extended" />
  <link:definitionLink xlink:role="http://www.lilly.com/role/CoverPage" xlink:type="extended">
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_DocumentInformationLineItems" xlink:label="loc_dei_DocumentInformationLineItems_A57C256B41F151A22ABE118B6D00AB2B" xlink:type="locator" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_DocumentInformationTable" xlink:label="loc_dei_DocumentInformationTable_D22B6DBA38BFE5293555118B6CFCB623" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_dei_DocumentInformationLineItems_A57C256B41F151A22ABE118B6D00AB2B" xlink:to="loc_dei_DocumentInformationTable_D22B6DBA38BFE5293555118B6CFCB623" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementClassOfStockAxis" xlink:label="loc_us-gaap_StatementClassOfStockAxis_7A2FA67B37F9FA7664FC118B6CFC659D" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_dei_DocumentInformationTable_D22B6DBA38BFE5293555118B6CFCB623" xlink:to="loc_us-gaap_StatementClassOfStockAxis_7A2FA67B37F9FA7664FC118B6CFC659D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ClassOfStockDomain" xlink:label="loc_us-gaap_ClassOfStockDomain_5374FE35237CC2CD18C5118B6CFDF971_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementClassOfStockAxis_7A2FA67B37F9FA7664FC118B6CFC659D" xlink:to="loc_us-gaap_ClassOfStockDomain_5374FE35237CC2CD18C5118B6CFDF971_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ClassOfStockDomain" xlink:label="loc_us-gaap_ClassOfStockDomain_5374FE35237CC2CD18C5118B6CFDF971" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementClassOfStockAxis_7A2FA67B37F9FA7664FC118B6CFC659D" xlink:to="loc_us-gaap_ClassOfStockDomain_5374FE35237CC2CD18C5118B6CFDF971" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CommonClassAMember" xlink:label="loc_us-gaap_CommonClassAMember_2BD25FDCB2075EC85894118B6CFDBFD3" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_5374FE35237CC2CD18C5118B6CFDF971" xlink:to="loc_us-gaap_CommonClassAMember_2BD25FDCB2075EC85894118B6CFDBFD3" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_A1.000NotesDueJune22022Member" xlink:label="loc_lly_A1.000NotesDueJune22022Member_6176A95932D670CE3ED8118B6CFE2914" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_5374FE35237CC2CD18C5118B6CFDF971" xlink:to="loc_lly_A1.000NotesDueJune22022Member_6176A95932D670CE3ED8118B6CFE2914" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_A718NotesDueJune12025Member" xlink:label="loc_lly_A718NotesDueJune12025Member_B33EACD420EE5AAB96A7118B6CFE5CF1" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_5374FE35237CC2CD18C5118B6CFDF971" xlink:to="loc_lly_A718NotesDueJune12025Member_B33EACD420EE5AAB96A7118B6CFE5CF1" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_A1.625NotesDueJune22026Member" xlink:label="loc_lly_A1.625NotesDueJune22026Member_A26AD30D05760E2C9068118B6CFE457E" xlink:type="locator" />
    <link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_5374FE35237CC2CD18C5118B6CFDF971" xlink:to="loc_lly_A1.625NotesDueJune22026Member_A26AD30D05760E2C9068118B6CFE457E" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_A2.125NotesDueJune32030Member" xlink:label="loc_lly_A2.125NotesDueJune32030Member_14B30F53E512F96155B8118B6CFEF803" xlink:type="locator" />
    <link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_5374FE35237CC2CD18C5118B6CFDF971" xlink:to="loc_lly_A2.125NotesDueJune32030Member_14B30F53E512F96155B8118B6CFEF803" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_A625Notesdue2031Member" xlink:label="loc_lly_A625Notesdue2031Member_D840EAF12C11D99C75FF118B6CFFA2F3" xlink:type="locator" />
    <link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_5374FE35237CC2CD18C5118B6CFDF971" xlink:to="loc_lly_A625Notesdue2031Member_D840EAF12C11D99C75FF118B6CFFA2F3" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_A6.77NotesDueJanuary12036Member" xlink:label="loc_lly_A6.77NotesDueJanuary12036Member_34014E34152740593E6B118B6CFF59D7" xlink:type="locator" />
    <link:definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_5374FE35237CC2CD18C5118B6CFDF971" xlink:to="loc_lly_A6.77NotesDueJanuary12036Member_34014E34152740593E6B118B6CFF59D7" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_A1.700Notesdue2049Member" xlink:label="loc_lly_A1.700Notesdue2049Member_42D23C1892448BF17A9B118B6CFF7010" xlink:type="locator" />
    <link:definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_5374FE35237CC2CD18C5118B6CFDF971" xlink:to="loc_lly_A1.700Notesdue2049Member_42D23C1892448BF17A9B118B6CFF7010" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_DocumentType" xlink:label="loc_dei_DocumentType_888A711FDB83A00AB4AF118B6D00855A" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_A57C256B41F151A22ABE118B6D00AB2B" xlink:to="loc_dei_DocumentType_888A711FDB83A00AB4AF118B6D00855A" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_DocumentPeriodEndDate" xlink:label="loc_dei_DocumentPeriodEndDate_E5CD17D0D3847C7D9ED0118B6D00895D" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_A57C256B41F151A22ABE118B6D00AB2B" xlink:to="loc_dei_DocumentPeriodEndDate_E5CD17D0D3847C7D9ED0118B6D00895D" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityFileNumber" xlink:label="loc_dei_EntityFileNumber_BC4820840D3B74A4D2BB118B6D00460D" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_A57C256B41F151A22ABE118B6D00AB2B" xlink:to="loc_dei_EntityFileNumber_BC4820840D3B74A4D2BB118B6D00460D" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityRegistrantName" xlink:label="loc_dei_EntityRegistrantName_34381D9E00C6B25F7AFF118B6D0055DF" xlink:type="locator" />
    <link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_A57C256B41F151A22ABE118B6D00AB2B" xlink:to="loc_dei_EntityRegistrantName_34381D9E00C6B25F7AFF118B6D0055DF" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityIncorporationStateCountryCode" xlink:label="loc_dei_EntityIncorporationStateCountryCode_687359CC478DB32863E5118B6D01ECD6" xlink:type="locator" />
    <link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_A57C256B41F151A22ABE118B6D00AB2B" xlink:to="loc_dei_EntityIncorporationStateCountryCode_687359CC478DB32863E5118B6D01ECD6" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityTaxIdentificationNumber" xlink:label="loc_dei_EntityTaxIdentificationNumber_6CFE9AA732ACC155DBB8118B6D015BD3" xlink:type="locator" />
    <link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_A57C256B41F151A22ABE118B6D00AB2B" xlink:to="loc_dei_EntityTaxIdentificationNumber_6CFE9AA732ACC155DBB8118B6D015BD3" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityAddressAddressLine1" xlink:label="loc_dei_EntityAddressAddressLine1_3BCA9EB7C289C0D2DB36118B6D015492" xlink:type="locator" />
    <link:definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_A57C256B41F151A22ABE118B6D00AB2B" xlink:to="loc_dei_EntityAddressAddressLine1_3BCA9EB7C289C0D2DB36118B6D015492" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityAddressCityOrTown" xlink:label="loc_dei_EntityAddressCityOrTown_9141153CDDD75A1D3599118B6D016C4B" xlink:type="locator" />
    <link:definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_A57C256B41F151A22ABE118B6D00AB2B" xlink:to="loc_dei_EntityAddressCityOrTown_9141153CDDD75A1D3599118B6D016C4B" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityAddressStateOrProvince" xlink:label="loc_dei_EntityAddressStateOrProvince_33D35A1EC1778043279E118B6D0193F8" xlink:type="locator" />
    <link:definitionArc order="9" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_A57C256B41F151A22ABE118B6D00AB2B" xlink:to="loc_dei_EntityAddressStateOrProvince_33D35A1EC1778043279E118B6D0193F8" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityAddressPostalZipCode" xlink:label="loc_dei_EntityAddressPostalZipCode_CBBFE61E08D04E53FD20118B6D016646" xlink:type="locator" />
    <link:definitionArc order="10" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_A57C256B41F151A22ABE118B6D00AB2B" xlink:to="loc_dei_EntityAddressPostalZipCode_CBBFE61E08D04E53FD20118B6D016646" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_CityAreaCode" xlink:label="loc_dei_CityAreaCode_427676666F40CD593E8B118B6D0227E9" xlink:type="locator" />
    <link:definitionArc order="11" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_A57C256B41F151A22ABE118B6D00AB2B" xlink:to="loc_dei_CityAreaCode_427676666F40CD593E8B118B6D0227E9" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_LocalPhoneNumber" xlink:label="loc_dei_LocalPhoneNumber_4F782666C141CAD721E9118B6D020648" xlink:type="locator" />
    <link:definitionArc order="12" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_A57C256B41F151A22ABE118B6D00AB2B" xlink:to="loc_dei_LocalPhoneNumber_4F782666C141CAD721E9118B6D020648" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_Security12bTitle" xlink:label="loc_dei_Security12bTitle_6710C7D322896D31A74E118B6D027521" xlink:type="locator" />
    <link:definitionArc order="13" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_A57C256B41F151A22ABE118B6D00AB2B" xlink:to="loc_dei_Security12bTitle_6710C7D322896D31A74E118B6D027521" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_TradingSymbol" xlink:label="loc_dei_TradingSymbol_477EE2BFCCB670E82954118B6D02AD55" xlink:type="locator" />
    <link:definitionArc order="14" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_A57C256B41F151A22ABE118B6D00AB2B" xlink:to="loc_dei_TradingSymbol_477EE2BFCCB670E82954118B6D02AD55" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_SecurityExchangeName" xlink:label="loc_dei_SecurityExchangeName_3B2C1089D9AECBDD47F7118B6D022640" xlink:type="locator" />
    <link:definitionArc order="15" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_A57C256B41F151A22ABE118B6D00AB2B" xlink:to="loc_dei_SecurityExchangeName_3B2C1089D9AECBDD47F7118B6D022640" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityWellKnownSeasonedIssuer" xlink:label="loc_dei_EntityWellKnownSeasonedIssuer_EC85FE6438910772534C118B6D035EE6" xlink:type="locator" />
    <link:definitionArc order="16" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_A57C256B41F151A22ABE118B6D00AB2B" xlink:to="loc_dei_EntityWellKnownSeasonedIssuer_EC85FE6438910772534C118B6D035EE6" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityVoluntaryFilers" xlink:label="loc_dei_EntityVoluntaryFilers_7D9922BE4118AEC54515118B6D03AC20" xlink:type="locator" />
    <link:definitionArc order="17" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_A57C256B41F151A22ABE118B6D00AB2B" xlink:to="loc_dei_EntityVoluntaryFilers_7D9922BE4118AEC54515118B6D03AC20" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityCurrentReportingStatus" xlink:label="loc_dei_EntityCurrentReportingStatus_5F52BA1B762B890B302C118B6D037FD6" xlink:type="locator" />
    <link:definitionArc order="18" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_A57C256B41F151A22ABE118B6D00AB2B" xlink:to="loc_dei_EntityCurrentReportingStatus_5F52BA1B762B890B302C118B6D037FD6" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityInteractiveDataCurrent" xlink:label="loc_dei_EntityInteractiveDataCurrent_82726D47917C36C55DB9118B6D03DADF" xlink:type="locator" />
    <link:definitionArc order="19" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_A57C256B41F151A22ABE118B6D00AB2B" xlink:to="loc_dei_EntityInteractiveDataCurrent_82726D47917C36C55DB9118B6D03DADF" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityFilerCategory" xlink:label="loc_dei_EntityFilerCategory_1139DC89AD179D26B89B118B6D03C21E" xlink:type="locator" />
    <link:definitionArc order="20" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_A57C256B41F151A22ABE118B6D00AB2B" xlink:to="loc_dei_EntityFilerCategory_1139DC89AD179D26B89B118B6D03C21E" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntitySmallBusiness" xlink:label="loc_dei_EntitySmallBusiness_29E9C100CC95CC60D3D2118B6D03D470" xlink:type="locator" />
    <link:definitionArc order="21" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_A57C256B41F151A22ABE118B6D00AB2B" xlink:to="loc_dei_EntitySmallBusiness_29E9C100CC95CC60D3D2118B6D03D470" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityEmergingGrowthCompany" xlink:label="loc_dei_EntityEmergingGrowthCompany_19126BA18E1F3BD16D81118B6D03701F" xlink:type="locator" />
    <link:definitionArc order="22" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_A57C256B41F151A22ABE118B6D00AB2B" xlink:to="loc_dei_EntityEmergingGrowthCompany_19126BA18E1F3BD16D81118B6D03701F" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityShellCompany" xlink:label="loc_dei_EntityShellCompany_B93E471C2BF616EE75CD118B6D049D9B" xlink:type="locator" />
    <link:definitionArc order="23" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_A57C256B41F151A22ABE118B6D00AB2B" xlink:to="loc_dei_EntityShellCompany_B93E471C2BF616EE75CD118B6D049D9B" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityPublicFloat" xlink:label="loc_dei_EntityPublicFloat_EDF176A002BE81BF9D70118B6D04B7FD" xlink:type="locator" />
    <link:definitionArc order="24" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_A57C256B41F151A22ABE118B6D00AB2B" xlink:to="loc_dei_EntityPublicFloat_EDF176A002BE81BF9D70118B6D04B7FD" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityCommonStockSharesOutstanding" xlink:label="loc_dei_EntityCommonStockSharesOutstanding_FA1119CB94A8F97E5674118B6D04B270" xlink:type="locator" />
    <link:definitionArc order="25" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_A57C256B41F151A22ABE118B6D00AB2B" xlink:to="loc_dei_EntityCommonStockSharesOutstanding_FA1119CB94A8F97E5674118B6D04B270" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_DocumentAnnualReport" xlink:label="loc_dei_DocumentAnnualReport_DF1CFCB076499A769197118B6D041EEC" xlink:type="locator" />
    <link:definitionArc order="26" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_A57C256B41F151A22ABE118B6D00AB2B" xlink:to="loc_dei_DocumentAnnualReport_DF1CFCB076499A769197118B6D041EEC" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_DocumentTransitionReport" xlink:label="loc_dei_DocumentTransitionReport_5539B2A5A87A5C93626D118B6D041776" xlink:type="locator" />
    <link:definitionArc order="27" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_A57C256B41F151A22ABE118B6D00AB2B" xlink:to="loc_dei_DocumentTransitionReport_5539B2A5A87A5C93626D118B6D041776" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_AmendmentFlag" xlink:label="loc_dei_AmendmentFlag_D9940265EB44982EAFC8118B6D054D3C" xlink:type="locator" />
    <link:definitionArc order="28" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_A57C256B41F151A22ABE118B6D00AB2B" xlink:to="loc_dei_AmendmentFlag_D9940265EB44982EAFC8118B6D054D3C" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_DocumentFiscalYearFocus" xlink:label="loc_dei_DocumentFiscalYearFocus_44E9C831284F54F1F4B2118B6D058107" xlink:type="locator" />
    <link:definitionArc order="29" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_A57C256B41F151A22ABE118B6D00AB2B" xlink:to="loc_dei_DocumentFiscalYearFocus_44E9C831284F54F1F4B2118B6D058107" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_DocumentFiscalPeriodFocus" xlink:label="loc_dei_DocumentFiscalPeriodFocus_4077DECE0DCA6B2544E8118B6D053671" xlink:type="locator" />
    <link:definitionArc order="30" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_A57C256B41F151A22ABE118B6D00AB2B" xlink:to="loc_dei_DocumentFiscalPeriodFocus_4077DECE0DCA6B2544E8118B6D053671" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityCentralIndexKey" xlink:label="loc_dei_EntityCentralIndexKey_BDA4A98D632BE4F931DA118B6D0558D8" xlink:type="locator" />
    <link:definitionArc order="31" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_A57C256B41F151A22ABE118B6D00AB2B" xlink:to="loc_dei_EntityCentralIndexKey_BDA4A98D632BE4F931DA118B6D0558D8" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_CurrentFiscalYearEndDate" xlink:label="loc_dei_CurrentFiscalYearEndDate_FBD8A6C7CE2BB85D2234118B6D050A81" xlink:type="locator" />
    <link:definitionArc order="32" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_A57C256B41F151A22ABE118B6D00AB2B" xlink:to="loc_dei_CurrentFiscalYearEndDate_FBD8A6C7CE2BB85D2234118B6D050A81" xlink:type="arc" />
  </link:definitionLink>
  <link:definitionLink xlink:role="http://www.lilly.com/role/DiscontinuedOperations" xlink:type="extended" />
  <link:definitionLink xlink:role="http://www.lilly.com/role/DiscontinuedOperationsDiscontinuedOperationsInFinancialStatementsDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems" xlink:label="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_550DA62928E147995D56AE57C571DE80" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsTable" xlink:label="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsTable_D92B3ABBD7B6B947B958AE57C56AE7DF" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_550DA62928E147995D56AE57C571DE80" xlink:to="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsTable_D92B3ABBD7B6B947B958AE57C56AE7DF" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis" xlink:label="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis_74AD1E9F06F0D17AE85BAE57C56ACA42" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsTable_D92B3ABBD7B6B947B958AE57C56AE7DF" xlink:to="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis_74AD1E9F06F0D17AE85BAE57C56ACA42" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain" xlink:label="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_FF907019626B86F97149AE57C56BC944_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis_74AD1E9F06F0D17AE85BAE57C56ACA42" xlink:to="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_FF907019626B86F97149AE57C56BC944_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain" xlink:label="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_FF907019626B86F97149AE57C56BC944" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis_74AD1E9F06F0D17AE85BAE57C56ACA42" xlink:to="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_FF907019626B86F97149AE57C56BC944" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_ElancoAnimalHealthIncorporatedMember" xlink:label="loc_lly_ElancoAnimalHealthIncorporatedMember_31C813C5A96F058A8D57AE57C5702BA7" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_FF907019626B86F97149AE57C56BC944" xlink:to="loc_lly_ElancoAnimalHealthIncorporatedMember_31C813C5A96F058A8D57AE57C5702BA7" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DisposalGroupClassificationAxis" xlink:label="loc_us-gaap_DisposalGroupClassificationAxis_0A2513D4D5C51E5CB7F2AE57C5704C5A" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsTable_D92B3ABBD7B6B947B958AE57C56AE7DF" xlink:to="loc_us-gaap_DisposalGroupClassificationAxis_0A2513D4D5C51E5CB7F2AE57C5704C5A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DisposalGroupClassificationDomain" xlink:label="loc_us-gaap_DisposalGroupClassificationDomain_5F4FEC2A9D4664BA82DDAE57C5714B9C_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DisposalGroupClassificationAxis_0A2513D4D5C51E5CB7F2AE57C5704C5A" xlink:to="loc_us-gaap_DisposalGroupClassificationDomain_5F4FEC2A9D4664BA82DDAE57C5714B9C_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DisposalGroupClassificationDomain" xlink:label="loc_us-gaap_DisposalGroupClassificationDomain_5F4FEC2A9D4664BA82DDAE57C5714B9C" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DisposalGroupClassificationAxis_0A2513D4D5C51E5CB7F2AE57C5704C5A" xlink:to="loc_us-gaap_DisposalGroupClassificationDomain_5F4FEC2A9D4664BA82DDAE57C5714B9C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DiscontinuedOperationsDisposedOfBySaleMember" xlink:label="loc_us-gaap_DiscontinuedOperationsDisposedOfBySaleMember_F62B776C6359834B59CCAE57C5712416" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DisposalGroupClassificationDomain_5F4FEC2A9D4664BA82DDAE57C5714B9C" xlink:to="loc_us-gaap_DiscontinuedOperationsDisposedOfBySaleMember_F62B776C6359834B59CCAE57C5712416" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_Revenues" xlink:label="loc_us-gaap_Revenues_A22DDC776AC1D49AD9EEAE57C571F28C" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_550DA62928E147995D56AE57C571DE80" xlink:to="loc_us-gaap_Revenues_A22DDC776AC1D49AD9EEAE57C571F28C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTax" xlink:label="loc_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTax_A9717600F90CA8E02F6EAE57C572106F" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_550DA62928E147995D56AE57C571DE80" xlink:to="loc_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTax_A9717600F90CA8E02F6EAE57C572106F" xlink:type="arc" />
  </link:definitionLink>
  <link:definitionLink xlink:role="http://www.lilly.com/role/DiscontinuedOperationsMajorClassesOfAssetsAndLiabilitiesDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems" xlink:label="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_11E8E3DC327F38454BDDAA78A92C70A0" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsTable" xlink:label="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsTable_876CC456A268DCC20270AA78A8F7D141" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_11E8E3DC327F38454BDDAA78A92C70A0" xlink:to="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsTable_876CC456A268DCC20270AA78A8F7D141" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis" xlink:label="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis_0D5BB4551F16710F10EEAA78A92B9B3D" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsTable_876CC456A268DCC20270AA78A8F7D141" xlink:to="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis_0D5BB4551F16710F10EEAA78A92B9B3D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain" xlink:label="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_838AD0489735A32448FEAA78A92B6485_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis_0D5BB4551F16710F10EEAA78A92B9B3D" xlink:to="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_838AD0489735A32448FEAA78A92B6485_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain" xlink:label="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_838AD0489735A32448FEAA78A92B6485" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis_0D5BB4551F16710F10EEAA78A92B9B3D" xlink:to="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_838AD0489735A32448FEAA78A92B6485" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_ElancoAnimalHealthIncorporatedMember" xlink:label="loc_lly_ElancoAnimalHealthIncorporatedMember_E3B56EE417B2F42FECDEAA78A92BD555" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_838AD0489735A32448FEAA78A92B6485" xlink:to="loc_lly_ElancoAnimalHealthIncorporatedMember_E3B56EE417B2F42FECDEAA78A92BD555" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DisposalGroupClassificationAxis" xlink:label="loc_us-gaap_DisposalGroupClassificationAxis_605F80711FD094F6597AAA78A92CD268" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsTable_876CC456A268DCC20270AA78A8F7D141" xlink:to="loc_us-gaap_DisposalGroupClassificationAxis_605F80711FD094F6597AAA78A92CD268" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DisposalGroupClassificationDomain" xlink:label="loc_us-gaap_DisposalGroupClassificationDomain_958B8253DEB0B727D859AA78A92CB482_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DisposalGroupClassificationAxis_605F80711FD094F6597AAA78A92CD268" xlink:to="loc_us-gaap_DisposalGroupClassificationDomain_958B8253DEB0B727D859AA78A92CB482_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DisposalGroupClassificationDomain" xlink:label="loc_us-gaap_DisposalGroupClassificationDomain_958B8253DEB0B727D859AA78A92CB482" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DisposalGroupClassificationAxis_605F80711FD094F6597AAA78A92CD268" xlink:to="loc_us-gaap_DisposalGroupClassificationDomain_958B8253DEB0B727D859AA78A92CB482" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DiscontinuedOperationsDisposedOfBySaleMember" xlink:label="loc_us-gaap_DiscontinuedOperationsDisposedOfBySaleMember_E73CF50F2483DE25D5E1AA78A92C5C8A" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DisposalGroupClassificationDomain_958B8253DEB0B727D859AA78A92CB482" xlink:to="loc_us-gaap_DiscontinuedOperationsDisposedOfBySaleMember_E73CF50F2483DE25D5E1AA78A92C5C8A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DisposalGroupIncludingDiscontinuedOperationInventoryCurrent" xlink:label="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationInventoryCurrent_6D004D0E3BE34103409EAA78A92C4CCB" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_11E8E3DC327F38454BDDAA78A92C70A0" xlink:to="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationInventoryCurrent_6D004D0E3BE34103409EAA78A92C4CCB" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DisposalGroupIncludingDiscontinuedOperationOtherCurrentAssets" xlink:label="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationOtherCurrentAssets_C067966277A2AAA3D126AA78A92DA0FA" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_11E8E3DC327F38454BDDAA78A92C70A0" xlink:to="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationOtherCurrentAssets_C067966277A2AAA3D126AA78A92DA0FA" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AssetsOfDisposalGroupIncludingDiscontinuedOperationCurrent" xlink:label="loc_us-gaap_AssetsOfDisposalGroupIncludingDiscontinuedOperationCurrent_921F90DAB60A95B8BC9BAA78A92D647E" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_11E8E3DC327F38454BDDAA78A92C70A0" xlink:to="loc_us-gaap_AssetsOfDisposalGroupIncludingDiscontinuedOperationCurrent_921F90DAB60A95B8BC9BAA78A92D647E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DisposalGroupIncludingDiscontinuedOperationGoodwillNoncurrent" xlink:label="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationGoodwillNoncurrent_F06ACC2B81777013DAEFAA78A92DD40F" xlink:type="locator" />
    <link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_11E8E3DC327F38454BDDAA78A92C70A0" xlink:to="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationGoodwillNoncurrent_F06ACC2B81777013DAEFAA78A92DD40F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DisposalGroupIncludingDiscontinuedOperationIntangibleAssetsNoncurrent" xlink:label="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationIntangibleAssetsNoncurrent_28CE1D7797F0F9513C2BAA78A92D4419" xlink:type="locator" />
    <link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_11E8E3DC327F38454BDDAA78A92C70A0" xlink:to="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationIntangibleAssetsNoncurrent_28CE1D7797F0F9513C2BAA78A92D4419" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DisposalGroupIncludingDiscontinuedOperationPropertyPlantAndEquipmentNoncurrent" xlink:label="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationPropertyPlantAndEquipmentNoncurrent_D0517AEB83C0178D5845AA78A92E3E64" xlink:type="locator" />
    <link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_11E8E3DC327F38454BDDAA78A92C70A0" xlink:to="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationPropertyPlantAndEquipmentNoncurrent_D0517AEB83C0178D5845AA78A92E3E64" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DisposalGroupIncludingDiscontinuedOperationOtherNoncurrentAssets" xlink:label="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationOtherNoncurrentAssets_F297D34D1182E208F8D9AA78A92EBEA7" xlink:type="locator" />
    <link:definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_11E8E3DC327F38454BDDAA78A92C70A0" xlink:to="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationOtherNoncurrentAssets_F297D34D1182E208F8D9AA78A92EBEA7" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DisposalGroupIncludingDiscontinuedOperationAssetsNoncurrent" xlink:label="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationAssetsNoncurrent_B5C5B602D5B844709D21AA78A92E42C7" xlink:type="locator" />
    <link:definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_11E8E3DC327F38454BDDAA78A92C70A0" xlink:to="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationAssetsNoncurrent_B5C5B602D5B844709D21AA78A92E42C7" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LiabilitiesOfDisposalGroupIncludingDiscontinuedOperationCurrent" xlink:label="loc_us-gaap_LiabilitiesOfDisposalGroupIncludingDiscontinuedOperationCurrent_34E6C4188FE796955C60AA78A92E763E" xlink:type="locator" />
    <link:definitionArc order="9" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_11E8E3DC327F38454BDDAA78A92C70A0" xlink:to="loc_us-gaap_LiabilitiesOfDisposalGroupIncludingDiscontinuedOperationCurrent_34E6C4188FE796955C60AA78A92E763E" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_DisposalGroupIncludingDiscontinuedOperationDebtNoncurrent" xlink:label="loc_lly_DisposalGroupIncludingDiscontinuedOperationDebtNoncurrent_3CE5AD9B8B26883FBFFDAA78A92E5C05" xlink:type="locator" />
    <link:definitionArc order="10" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_11E8E3DC327F38454BDDAA78A92C70A0" xlink:to="loc_lly_DisposalGroupIncludingDiscontinuedOperationDebtNoncurrent_3CE5AD9B8B26883FBFFDAA78A92E5C05" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DisposalGroupIncludingDiscontinuedOperationOtherNoncurrentLiabilities" xlink:label="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationOtherNoncurrentLiabilities_840ADEB2BBFFC7BA8E27AA78A92E5079" xlink:type="locator" />
    <link:definitionArc order="11" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_11E8E3DC327F38454BDDAA78A92C70A0" xlink:to="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationOtherNoncurrentLiabilities_840ADEB2BBFFC7BA8E27AA78A92E5079" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LiabilitiesOfDisposalGroupIncludingDiscontinuedOperationNoncurrent" xlink:label="loc_us-gaap_LiabilitiesOfDisposalGroupIncludingDiscontinuedOperationNoncurrent_8E70CF66BAD04021CB46AA78A92FDF13" xlink:type="locator" />
    <link:definitionArc order="12" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_11E8E3DC327F38454BDDAA78A92C70A0" xlink:to="loc_us-gaap_LiabilitiesOfDisposalGroupIncludingDiscontinuedOperationNoncurrent_8E70CF66BAD04021CB46AA78A92FDF13" xlink:type="arc" />
  </link:definitionLink>
  <link:definitionLink xlink:role="http://www.lilly.com/role/DiscontinuedOperationsNarrativeDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems" xlink:label="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_68CF9398B3CD9068448E9FF20CF4A40C" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsTable" xlink:label="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsTable_EBBAEFFF5F2D2EE4E3A89FF20CEF4131" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_68CF9398B3CD9068448E9FF20CF4A40C" xlink:to="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsTable_EBBAEFFF5F2D2EE4E3A89FF20CEF4131" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SubsidiarySaleOfStockAxis" xlink:label="loc_us-gaap_SubsidiarySaleOfStockAxis_A987970E2C8AA129DFD89FF20CEFD14B" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsTable_EBBAEFFF5F2D2EE4E3A89FF20CEF4131" xlink:to="loc_us-gaap_SubsidiarySaleOfStockAxis_A987970E2C8AA129DFD89FF20CEFD14B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SaleOfStockNameOfTransactionDomain" xlink:label="loc_us-gaap_SaleOfStockNameOfTransactionDomain_5701135C53E09D7F4A0E9FF20CF024EC_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_SubsidiarySaleOfStockAxis_A987970E2C8AA129DFD89FF20CEFD14B" xlink:to="loc_us-gaap_SaleOfStockNameOfTransactionDomain_5701135C53E09D7F4A0E9FF20CF024EC_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SaleOfStockNameOfTransactionDomain" xlink:label="loc_us-gaap_SaleOfStockNameOfTransactionDomain_5701135C53E09D7F4A0E9FF20CF024EC" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_SubsidiarySaleOfStockAxis_A987970E2C8AA129DFD89FF20CEFD14B" xlink:to="loc_us-gaap_SaleOfStockNameOfTransactionDomain_5701135C53E09D7F4A0E9FF20CF024EC" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IPOMember" xlink:label="loc_us-gaap_IPOMember_CDAC94B3DA8B0D84D7919FF20CF08BA3" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SaleOfStockNameOfTransactionDomain_5701135C53E09D7F4A0E9FF20CF024EC" xlink:to="loc_us-gaap_IPOMember_CDAC94B3DA8B0D84D7919FF20CF08BA3" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_LegalEntityAxis" xlink:label="loc_dei_LegalEntityAxis_3B6B54FFAD9E58F94A119FF20CF07967" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsTable_EBBAEFFF5F2D2EE4E3A89FF20CEF4131" xlink:to="loc_dei_LegalEntityAxis_3B6B54FFAD9E58F94A119FF20CF07967" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityDomain" xlink:label="loc_dei_EntityDomain_BA1971882923A2A3C2FB9FF20CF1A153_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_dei_LegalEntityAxis_3B6B54FFAD9E58F94A119FF20CF07967" xlink:to="loc_dei_EntityDomain_BA1971882923A2A3C2FB9FF20CF1A153_default" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityDomain" xlink:label="loc_dei_EntityDomain_BA1971882923A2A3C2FB9FF20CF1A153" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_dei_LegalEntityAxis_3B6B54FFAD9E58F94A119FF20CF07967" xlink:to="loc_dei_EntityDomain_BA1971882923A2A3C2FB9FF20CF1A153" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_ElancoAnimalHealthIncorporatedMember" xlink:label="loc_lly_ElancoAnimalHealthIncorporatedMember_8BE177C02363FB9ADE259FF20CF1A1C6" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_BA1971882923A2A3C2FB9FF20CF1A153" xlink:to="loc_lly_ElancoAnimalHealthIncorporatedMember_8BE177C02363FB9ADE259FF20CF1A1C6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LongtermDebtTypeAxis" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_D2B7EEE6601F9724F8779FF20CF14AC7" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsTable_EBBAEFFF5F2D2EE4E3A89FF20CEF4131" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_D2B7EEE6601F9724F8779FF20CF14AC7" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LongtermDebtTypeDomain" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_1F2807A0346488E3C8299FF20CF14A71_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_D2B7EEE6601F9724F8779FF20CF14AC7" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_1F2807A0346488E3C8299FF20CF14A71_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LongtermDebtTypeDomain" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_1F2807A0346488E3C8299FF20CF14A71" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_D2B7EEE6601F9724F8779FF20CF14AC7" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_1F2807A0346488E3C8299FF20CF14A71" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_TermFacilityMember" xlink:label="loc_lly_TermFacilityMember_9FD1CAB0B921CFE5215C9FF20CF2A8A0" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_1F2807A0346488E3C8299FF20CF14A71" xlink:to="loc_lly_TermFacilityMember_9FD1CAB0B921CFE5215C9FF20CF2A8A0" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis" xlink:label="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis_336FB2E7DFCAA1FE43629FF20CF21A0E" xlink:type="locator" />
    <link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsTable_EBBAEFFF5F2D2EE4E3A89FF20CEF4131" xlink:to="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis_336FB2E7DFCAA1FE43629FF20CF21A0E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain" xlink:label="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_EFD21E08E56D2D1470729FF20CF2BD3A_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis_336FB2E7DFCAA1FE43629FF20CF21A0E" xlink:to="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_EFD21E08E56D2D1470729FF20CF2BD3A_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain" xlink:label="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_EFD21E08E56D2D1470729FF20CF2BD3A" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis_336FB2E7DFCAA1FE43629FF20CF21A0E" xlink:to="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_EFD21E08E56D2D1470729FF20CF2BD3A" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_ElancoAnimalHealthIncorporatedMember" xlink:label="loc_lly_ElancoAnimalHealthIncorporatedMember_ED36344BBBDDE9445C9F9FF20CF28AC2" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_EFD21E08E56D2D1470729FF20CF2BD3A" xlink:to="loc_lly_ElancoAnimalHealthIncorporatedMember_ED36344BBBDDE9445C9F9FF20CF28AC2" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DisposalGroupClassificationAxis" xlink:label="loc_us-gaap_DisposalGroupClassificationAxis_EAC4CBD683C5529DF8919FF20CF34113" xlink:type="locator" />
    <link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsTable_EBBAEFFF5F2D2EE4E3A89FF20CEF4131" xlink:to="loc_us-gaap_DisposalGroupClassificationAxis_EAC4CBD683C5529DF8919FF20CF34113" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DisposalGroupClassificationDomain" xlink:label="loc_us-gaap_DisposalGroupClassificationDomain_FAAD88DBC59D0F7EF17D9FF20CF3EBE5_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DisposalGroupClassificationAxis_EAC4CBD683C5529DF8919FF20CF34113" xlink:to="loc_us-gaap_DisposalGroupClassificationDomain_FAAD88DBC59D0F7EF17D9FF20CF3EBE5_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DisposalGroupClassificationDomain" xlink:label="loc_us-gaap_DisposalGroupClassificationDomain_FAAD88DBC59D0F7EF17D9FF20CF3EBE5" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DisposalGroupClassificationAxis_EAC4CBD683C5529DF8919FF20CF34113" xlink:to="loc_us-gaap_DisposalGroupClassificationDomain_FAAD88DBC59D0F7EF17D9FF20CF3EBE5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DiscontinuedOperationsDisposedOfBySaleMember" xlink:label="loc_us-gaap_DiscontinuedOperationsDisposedOfBySaleMember_2354109A724A889A44DD9FF20CF35DEC" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DisposalGroupClassificationDomain_FAAD88DBC59D0F7EF17D9FF20CF3EBE5" xlink:to="loc_us-gaap_DiscontinuedOperationsDisposedOfBySaleMember_2354109A724A889A44DD9FF20CF35DEC" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SaleOfStockNumberOfSharesIssuedInTransaction" xlink:label="loc_us-gaap_SaleOfStockNumberOfSharesIssuedInTransaction_7BBB74CC284D060380BC9FF20CF499CD" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_68CF9398B3CD9068448E9FF20CF4A40C" xlink:to="loc_us-gaap_SaleOfStockNumberOfSharesIssuedInTransaction_7BBB74CC284D060380BC9FF20CF499CD" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_SaleOfStockPercentageOfStockSold" xlink:label="loc_lly_SaleOfStockPercentageOfStockSold_2098E684CD6B2D0CBEF29FF20CF4E076" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_68CF9398B3CD9068448E9FF20CF4A40C" xlink:to="loc_lly_SaleOfStockPercentageOfStockSold_2098E684CD6B2D0CBEF29FF20CF4E076" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SaleOfStockPricePerShare" xlink:label="loc_us-gaap_SaleOfStockPricePerShare_C7E18774965A57D054979FF20CF4D836" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_68CF9398B3CD9068448E9FF20CF4A40C" xlink:to="loc_us-gaap_SaleOfStockPricePerShare_C7E18774965A57D054979FF20CF4D836" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DisposalGroupIncludingDiscontinuedOperationConsideration" xlink:label="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationConsideration_2C5BDCBECFACD0DF81A29FF20CF4AF0E" xlink:type="locator" />
    <link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_68CF9398B3CD9068448E9FF20CF4A40C" xlink:to="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationConsideration_2C5BDCBECFACD0DF81A29FF20CF4AF0E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ProceedsFromIssuanceOfDebt" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfDebt_D7C6FD77D27EC116EB1C9FF20CF5BCC1" xlink:type="locator" />
    <link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_68CF9398B3CD9068448E9FF20CF4A40C" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfDebt_D7C6FD77D27EC116EB1C9FF20CF5BCC1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtInstrumentFaceAmount" xlink:label="loc_us-gaap_DebtInstrumentFaceAmount_0E77BB40D338800B64B99FF20CF5A399" xlink:type="locator" />
    <link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_68CF9398B3CD9068448E9FF20CF4A40C" xlink:to="loc_us-gaap_DebtInstrumentFaceAmount_0E77BB40D338800B64B99FF20CF5A399" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtInstrumentTerm" xlink:label="loc_us-gaap_DebtInstrumentTerm_1F37EC4DCC180FC813589FF20CF5F8EB" xlink:type="locator" />
    <link:definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_68CF9398B3CD9068448E9FF20CF4A40C" xlink:to="loc_us-gaap_DebtInstrumentTerm_1F37EC4DCC180FC813589FF20CF5F8EB" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AdditionalPaidInCapital" xlink:label="loc_us-gaap_AdditionalPaidInCapital_26F3616937E39B5C74E19FF20CF533CC" xlink:type="locator" />
    <link:definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_68CF9398B3CD9068448E9FF20CF4A40C" xlink:to="loc_us-gaap_AdditionalPaidInCapital_26F3616937E39B5C74E19FF20CF533CC" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_MinorityInterest" xlink:label="loc_us-gaap_MinorityInterest_D1A08C18C1268CAFAC839FF20CF55BD0" xlink:type="locator" />
    <link:definitionArc order="9" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_68CF9398B3CD9068448E9FF20CF4A40C" xlink:to="loc_us-gaap_MinorityInterest_D1A08C18C1268CAFAC839FF20CF55BD0" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_MinorityInterestOwnershipPercentageByParent" xlink:label="loc_us-gaap_MinorityInterestOwnershipPercentageByParent_5F09ABBE283A432EF9D09FF20CF51592" xlink:type="locator" />
    <link:definitionArc order="10" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_68CF9398B3CD9068448E9FF20CF4A40C" xlink:to="loc_us-gaap_MinorityInterestOwnershipPercentageByParent_5F09ABBE283A432EF9D09FF20CF51592" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_GainLossOnSaleOfBusiness" xlink:label="loc_us-gaap_GainLossOnSaleOfBusiness_E4EDF2C2E66236BF2DF89FF20CF6A225" xlink:type="locator" />
    <link:definitionArc order="11" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_68CF9398B3CD9068448E9FF20CF4A40C" xlink:to="loc_us-gaap_GainLossOnSaleOfBusiness_E4EDF2C2E66236BF2DF89FF20CF6A225" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CashProvidedByUsedInOperatingActivitiesDiscontinuedOperations" xlink:label="loc_us-gaap_CashProvidedByUsedInOperatingActivitiesDiscontinuedOperations_99240CB8F0B47A7A7F9C9FF20CF6E21D" xlink:type="locator" />
    <link:definitionArc order="12" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_68CF9398B3CD9068448E9FF20CF4A40C" xlink:to="loc_us-gaap_CashProvidedByUsedInOperatingActivitiesDiscontinuedOperations_99240CB8F0B47A7A7F9C9FF20CF6E21D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CashProvidedByUsedInInvestingActivitiesDiscontinuedOperations" xlink:label="loc_us-gaap_CashProvidedByUsedInInvestingActivitiesDiscontinuedOperations_1010FD715A12270FB17F9FF20CF6F020" xlink:type="locator" />
    <link:definitionArc order="13" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_68CF9398B3CD9068448E9FF20CF4A40C" xlink:to="loc_us-gaap_CashProvidedByUsedInInvestingActivitiesDiscontinuedOperations_1010FD715A12270FB17F9FF20CF6F020" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_DisposalGroupIncludingDiscontinuedOperationTransitionalServicesAgreementTerm" xlink:label="loc_lly_DisposalGroupIncludingDiscontinuedOperationTransitionalServicesAgreementTerm_C21252C639960740A4ED9FF20CF6F01F" xlink:type="locator" />
    <link:definitionArc order="14" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_68CF9398B3CD9068448E9FF20CF4A40C" xlink:to="loc_lly_DisposalGroupIncludingDiscontinuedOperationTransitionalServicesAgreementTerm_C21252C639960740A4ED9FF20CF6F01F" xlink:type="arc" />
  </link:definitionLink>
  <link:definitionLink xlink:role="http://www.lilly.com/role/DiscontinuedOperationsTables" xlink:type="extended" />
  <link:definitionLink xlink:role="http://www.lilly.com/role/FinancialInstruments" xlink:type="extended" />
  <link:definitionLink xlink:role="http://www.lilly.com/role/FinancialInstrumentsNarrativeDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeLineItems" xlink:label="loc_us-gaap_DerivativeLineItems_7E172665973700BD2D1BED93DAE35E43" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeTable" xlink:label="loc_us-gaap_DerivativeTable_2FFA3F4BDBAA7E60C185ED93DADEFDF8" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DerivativeLineItems_7E172665973700BD2D1BED93DAE35E43" xlink:to="loc_us-gaap_DerivativeTable_2FFA3F4BDBAA7E60C185ED93DADEFDF8" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis" xlink:label="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_6365AE7A14282F9212F8ED93DADE7D3E" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeTable_2FFA3F4BDBAA7E60C185ED93DADEFDF8" xlink:to="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_6365AE7A14282F9212F8ED93DADE7D3E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_HedgingRelationshipDomain" xlink:label="loc_us-gaap_HedgingRelationshipDomain_488428C8B896DA9F6BCAED93DADE2B50_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_6365AE7A14282F9212F8ED93DADE7D3E" xlink:to="loc_us-gaap_HedgingRelationshipDomain_488428C8B896DA9F6BCAED93DADE2B50_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_HedgingRelationshipDomain" xlink:label="loc_us-gaap_HedgingRelationshipDomain_488428C8B896DA9F6BCAED93DADE2B50" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_6365AE7A14282F9212F8ED93DADE7D3E" xlink:to="loc_us-gaap_HedgingRelationshipDomain_488428C8B896DA9F6BCAED93DADE2B50" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CashFlowHedgingMember" xlink:label="loc_us-gaap_CashFlowHedgingMember_E8AA5BA4B517FEFD8FE1ED93DADFB0F9" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingRelationshipDomain_488428C8B896DA9F6BCAED93DADE2B50" xlink:to="loc_us-gaap_CashFlowHedgingMember_E8AA5BA4B517FEFD8FE1ED93DADFB0F9" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_HedgingDesignationAxis" xlink:label="loc_us-gaap_HedgingDesignationAxis_18B6B75FC45EE2F351E4ED93DADF255E" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeTable_2FFA3F4BDBAA7E60C185ED93DADEFDF8" xlink:to="loc_us-gaap_HedgingDesignationAxis_18B6B75FC45EE2F351E4ED93DADF255E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_HedgingDesignationDomain" xlink:label="loc_us-gaap_HedgingDesignationDomain_2D9F41574F2C23E76AC5ED93DADFA773_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_HedgingDesignationAxis_18B6B75FC45EE2F351E4ED93DADF255E" xlink:to="loc_us-gaap_HedgingDesignationDomain_2D9F41574F2C23E76AC5ED93DADFA773_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_HedgingDesignationDomain" xlink:label="loc_us-gaap_HedgingDesignationDomain_2D9F41574F2C23E76AC5ED93DADFA773" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_HedgingDesignationAxis_18B6B75FC45EE2F351E4ED93DADF255E" xlink:to="loc_us-gaap_HedgingDesignationDomain_2D9F41574F2C23E76AC5ED93DADFA773" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DesignatedAsHedgingInstrumentMember" xlink:label="loc_us-gaap_DesignatedAsHedgingInstrumentMember_02168F975AB36FE0CCC4ED93DAE013B7" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingDesignationDomain_2D9F41574F2C23E76AC5ED93DADFA773" xlink:to="loc_us-gaap_DesignatedAsHedgingInstrumentMember_02168F975AB36FE0CCC4ED93DAE013B7" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LongtermDebtTypeAxis" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_53CCDFC7F4DC465F3A96ED93DAE00E1D" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeTable_2FFA3F4BDBAA7E60C185ED93DADEFDF8" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_53CCDFC7F4DC465F3A96ED93DAE00E1D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LongtermDebtTypeDomain" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_DEF403995584169DE850ED93DAE0A27C_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_53CCDFC7F4DC465F3A96ED93DAE00E1D" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_DEF403995584169DE850ED93DAE0A27C_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LongtermDebtTypeDomain" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_DEF403995584169DE850ED93DAE0A27C" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_53CCDFC7F4DC465F3A96ED93DAE00E1D" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_DEF403995584169DE850ED93DAE0A27C" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_ForeignCurrencyDenominatedDebtMember" xlink:label="loc_lly_ForeignCurrencyDenominatedDebtMember_061944CC7FC7247F8ECEED93DAE03C2E" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_DEF403995584169DE850ED93DAE0A27C" xlink:to="loc_lly_ForeignCurrencyDenominatedDebtMember_061944CC7FC7247F8ECEED93DAE03C2E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeInstrumentRiskAxis" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_00549C1B1108D9BDE79BED93DAE11538" xlink:type="locator" />
    <link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeTable_2FFA3F4BDBAA7E60C185ED93DADEFDF8" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_00549C1B1108D9BDE79BED93DAE11538" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeContractTypeDomain" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_F1F1284E166CEA8D8A6DED93DAE1C691_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_00549C1B1108D9BDE79BED93DAE11538" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_F1F1284E166CEA8D8A6DED93DAE1C691_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeContractTypeDomain" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_F1F1284E166CEA8D8A6DED93DAE1C691" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_00549C1B1108D9BDE79BED93DAE11538" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_F1F1284E166CEA8D8A6DED93DAE1C691" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_BuyUsdSellEuroMember" xlink:label="loc_lly_BuyUsdSellEuroMember_CE42975D8D99253B591FED93DAE1224E" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_F1F1284E166CEA8D8A6DED93DAE1C691" xlink:to="loc_lly_BuyUsdSellEuroMember_CE42975D8D99253B591FED93DAE1224E" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_BuyEuroSellUsDollarMember" xlink:label="loc_lly_BuyEuroSellUsDollarMember_2A813B68ACACABEAC35DED93DAE1E690" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_F1F1284E166CEA8D8A6DED93DAE1C691" xlink:to="loc_lly_BuyEuroSellUsDollarMember_2A813B68ACACABEAC35DED93DAE1E690" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_BuyUSdollarSellJapaneseYenMember" xlink:label="loc_lly_BuyUSdollarSellJapaneseYenMember_37AC16F2EAF382641CF6ED93DAE2FB9A" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_F1F1284E166CEA8D8A6DED93DAE1C691" xlink:to="loc_lly_BuyUSdollarSellJapaneseYenMember_37AC16F2EAF382641CF6ED93DAE2FB9A" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_BuySwissfrancsSellUSdollarMember" xlink:label="loc_lly_BuySwissfrancsSellUSdollarMember_05F1D1002B45FD75A0E9ED93DAE27A54" xlink:type="locator" />
    <link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_F1F1284E166CEA8D8A6DED93DAE1C691" xlink:to="loc_lly_BuySwissfrancsSellUSdollarMember_05F1D1002B45FD75A0E9ED93DAE27A54" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_BuyGBPSellUSDMember" xlink:label="loc_lly_BuyGBPSellUSDMember_E3A6E7585BD2A98A8993ED93DAE2FC89" xlink:type="locator" />
    <link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_F1F1284E166CEA8D8A6DED93DAE1C691" xlink:to="loc_lly_BuyGBPSellUSDMember_E3A6E7585BD2A98A8993ED93DAE2FC89" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CurrencySwapMember" xlink:label="loc_us-gaap_CurrencySwapMember_2686A694368E7298681EED93DAE252C9" xlink:type="locator" />
    <link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_F1F1284E166CEA8D8A6DED93DAE1C691" xlink:to="loc_us-gaap_CurrencySwapMember_2686A694368E7298681EED93DAE252C9" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_SwapSwissFrancsToU.S.DollarsMember" xlink:label="loc_lly_SwapSwissFrancsToU.S.DollarsMember_B74286490ED1A8571B1BED93DAE253F0" xlink:type="locator" />
    <link:definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_F1F1284E166CEA8D8A6DED93DAE1C691" xlink:to="loc_lly_SwapSwissFrancsToU.S.DollarsMember_B74286490ED1A8571B1BED93DAE253F0" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InterestRateSwapMember" xlink:label="loc_us-gaap_InterestRateSwapMember_A55F0D9DE63B350EF750ED93DAE37965" xlink:type="locator" />
    <link:definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_F1F1284E166CEA8D8A6DED93DAE1C691" xlink:to="loc_us-gaap_InterestRateSwapMember_A55F0D9DE63B350EF750ED93DAE37965" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AverageRemainingMaturityOfForeignCurrencyDerivatives1" xlink:label="loc_us-gaap_AverageRemainingMaturityOfForeignCurrencyDerivatives1_90E09CD038289D4022E1ED93DAE3A432" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_7E172665973700BD2D1BED93DAE35E43" xlink:to="loc_us-gaap_AverageRemainingMaturityOfForeignCurrencyDerivatives1_90E09CD038289D4022E1ED93DAE3A432" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeLiabilityNotionalAmount" xlink:label="loc_us-gaap_DerivativeLiabilityNotionalAmount_0ECC75FE3400145DFD96ED93DAE3D9D6" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_7E172665973700BD2D1BED93DAE35E43" xlink:to="loc_us-gaap_DerivativeLiabilityNotionalAmount_0ECC75FE3400145DFD96ED93DAE3D9D6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeAssetNotionalAmount" xlink:label="loc_us-gaap_DerivativeAssetNotionalAmount_82ACE08546D6AE7F1045ED93DAE3F616" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_7E172665973700BD2D1BED93DAE35E43" xlink:to="loc_us-gaap_DerivativeAssetNotionalAmount_82ACE08546D6AE7F1045ED93DAE3F616" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_MaximumRemainingMaturityOfForeignCurrencyDerivatives1" xlink:label="loc_us-gaap_MaximumRemainingMaturityOfForeignCurrencyDerivatives1_AF14F1A9708053CD9BBFED93DAE38953" xlink:type="locator" />
    <link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_7E172665973700BD2D1BED93DAE35E43" xlink:to="loc_us-gaap_MaximumRemainingMaturityOfForeignCurrencyDerivatives1_AF14F1A9708053CD9BBFED93DAE38953" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LongTermDebt" xlink:label="loc_us-gaap_LongTermDebt_297EB9FCA56699C60F9CED93DAE41ACF" xlink:type="locator" />
    <link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_7E172665973700BD2D1BED93DAE35E43" xlink:to="loc_us-gaap_LongTermDebt_297EB9FCA56699C60F9CED93DAE41ACF" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_TranslationAdjustmentForNetInvestmentHedgeNetOfTax" xlink:label="loc_us-gaap_TranslationAdjustmentForNetInvestmentHedgeNetOfTax_BA581ABC7556485FD0A9ED93DAE48D65" xlink:type="locator" />
    <link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_7E172665973700BD2D1BED93DAE35E43" xlink:to="loc_us-gaap_TranslationAdjustmentForNetInvestmentHedgeNetOfTax_BA581ABC7556485FD0A9ED93DAE48D65" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LongTermDebtPercentageBearingVariableInterestRate" xlink:label="loc_us-gaap_LongTermDebtPercentageBearingVariableInterestRate_AF0E44E0E1FE30AE62ABED93DAE4EF37" xlink:type="locator" />
    <link:definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_7E172665973700BD2D1BED93DAE35E43" xlink:to="loc_us-gaap_LongTermDebtPercentageBearingVariableInterestRate_AF0E44E0E1FE30AE62ABED93DAE4EF37" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeNotionalAmount" xlink:label="loc_us-gaap_DerivativeNotionalAmount_6BACFB58BB5197CC5A95ED93DAE488B1" xlink:type="locator" />
    <link:definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_7E172665973700BD2D1BED93DAE35E43" xlink:to="loc_us-gaap_DerivativeNotionalAmount_6BACFB58BB5197CC5A95ED93DAE488B1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InterestRateCashFlowHedgeGainLossToBeReclassifiedDuringNext12MonthsNet" xlink:label="loc_us-gaap_InterestRateCashFlowHedgeGainLossToBeReclassifiedDuringNext12MonthsNet_D8A62F4854E98F842A31ED93DAE49DBF" xlink:type="locator" />
    <link:definitionArc order="9" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_7E172665973700BD2D1BED93DAE35E43" xlink:to="loc_us-gaap_InterestRateCashFlowHedgeGainLossToBeReclassifiedDuringNext12MonthsNet_D8A62F4854E98F842A31ED93DAE49DBF" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EquitySecuritiesFvNiGainLoss" xlink:label="loc_us-gaap_EquitySecuritiesFvNiGainLoss_2525D09EB0E19F2DF750ED93DAE4AE29" xlink:type="locator" />
    <link:definitionArc order="10" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_7E172665973700BD2D1BED93DAE35E43" xlink:to="loc_us-gaap_EquitySecuritiesFvNiGainLoss_2525D09EB0E19F2DF750ED93DAE4AE29" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ImpairmentOfInvestments" xlink:label="loc_us-gaap_ImpairmentOfInvestments_02AEEA95E554BEDC5255ED93DAE49004" xlink:type="locator" />
    <link:definitionArc order="11" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_7E172665973700BD2D1BED93DAE35E43" xlink:to="loc_us-gaap_ImpairmentOfInvestments_02AEEA95E554BEDC5255ED93DAE49004" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AvailableforsaleSecuritiesInUnrealizedLossPositionsQualitativeDisclosureOtherPercentageOfNonperformingAssets" xlink:label="loc_us-gaap_AvailableforsaleSecuritiesInUnrealizedLossPositionsQualitativeDisclosureOtherPercentageOfNonperformingAssets_C451D156465CD5401B1BED93DAE5AE23" xlink:type="locator" />
    <link:definitionArc order="12" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_7E172665973700BD2D1BED93DAE35E43" xlink:to="loc_us-gaap_AvailableforsaleSecuritiesInUnrealizedLossPositionsQualitativeDisclosureOtherPercentageOfNonperformingAssets_C451D156465CD5401B1BED93DAE5AE23" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_TransferOfFinancialAssetsAccountedForAsSalesAmountDerecognized" xlink:label="loc_us-gaap_TransferOfFinancialAssetsAccountedForAsSalesAmountDerecognized_24A3F189E52E752DB48CED93DAE52667" xlink:type="locator" />
    <link:definitionArc order="13" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_7E172665973700BD2D1BED93DAE35E43" xlink:to="loc_us-gaap_TransferOfFinancialAssetsAccountedForAsSalesAmountDerecognized_24A3F189E52E752DB48CED93DAE52667" xlink:type="arc" />
  </link:definitionLink>
  <link:definitionLink xlink:role="http://www.lilly.com/role/FinancialInstrumentsPolicies" xlink:type="extended" />
  <link:definitionLink xlink:role="http://www.lilly.com/role/FinancialInstrumentsScheduleOfAfsUnrealizedGainLossDetails" xlink:type="extended" />
  <link:definitionLink xlink:role="http://www.lilly.com/role/FinancialInstrumentsScheduleOfContractualMaturitiesDetails" xlink:type="extended" />
  <link:definitionLink xlink:role="http://www.lilly.com/role/FinancialInstrumentsScheduleOfEffectOfRiskManagementDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeLineItems" xlink:label="loc_us-gaap_DerivativeLineItems_743DCDB5098EE708B349ED5618ACC5E8" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeTable" xlink:label="loc_us-gaap_DerivativeTable_8C2248E713D5062DD0F2ED5618A6A645" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DerivativeLineItems_743DCDB5098EE708B349ED5618ACC5E8" xlink:to="loc_us-gaap_DerivativeTable_8C2248E713D5062DD0F2ED5618A6A645" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_HedgingDesignationAxis" xlink:label="loc_us-gaap_HedgingDesignationAxis_0932709DE059E52831B6ED5618A6C85D" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeTable_8C2248E713D5062DD0F2ED5618A6A645" xlink:to="loc_us-gaap_HedgingDesignationAxis_0932709DE059E52831B6ED5618A6C85D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_HedgingDesignationDomain" xlink:label="loc_us-gaap_HedgingDesignationDomain_8A1A50C4B2B736AE9F81ED5618A73B8A_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_HedgingDesignationAxis_0932709DE059E52831B6ED5618A6C85D" xlink:to="loc_us-gaap_HedgingDesignationDomain_8A1A50C4B2B736AE9F81ED5618A73B8A_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_HedgingDesignationDomain" xlink:label="loc_us-gaap_HedgingDesignationDomain_8A1A50C4B2B736AE9F81ED5618A73B8A" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_HedgingDesignationAxis_0932709DE059E52831B6ED5618A6C85D" xlink:to="loc_us-gaap_HedgingDesignationDomain_8A1A50C4B2B736AE9F81ED5618A73B8A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DesignatedAsHedgingInstrumentMember" xlink:label="loc_us-gaap_DesignatedAsHedgingInstrumentMember_C657F76881B24A9249D1ED5618A8D96C" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingDesignationDomain_8A1A50C4B2B736AE9F81ED5618A73B8A" xlink:to="loc_us-gaap_DesignatedAsHedgingInstrumentMember_C657F76881B24A9249D1ED5618A8D96C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NondesignatedMember" xlink:label="loc_us-gaap_NondesignatedMember_485A96D0D2538BEECB73ED5618A8552E" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingDesignationDomain_8A1A50C4B2B736AE9F81ED5618A73B8A" xlink:to="loc_us-gaap_NondesignatedMember_485A96D0D2538BEECB73ED5618A8552E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis" xlink:label="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_6937A6414E84C0AD3B7EED5618A83325" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeTable_8C2248E713D5062DD0F2ED5618A6A645" xlink:to="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_6937A6414E84C0AD3B7EED5618A83325" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_HedgingRelationshipDomain" xlink:label="loc_us-gaap_HedgingRelationshipDomain_44CCEDD72E488D3D3479ED5618A92A9F_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_6937A6414E84C0AD3B7EED5618A83325" xlink:to="loc_us-gaap_HedgingRelationshipDomain_44CCEDD72E488D3D3479ED5618A92A9F_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_HedgingRelationshipDomain" xlink:label="loc_us-gaap_HedgingRelationshipDomain_44CCEDD72E488D3D3479ED5618A92A9F" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_6937A6414E84C0AD3B7EED5618A83325" xlink:to="loc_us-gaap_HedgingRelationshipDomain_44CCEDD72E488D3D3479ED5618A92A9F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CashFlowHedgingMember" xlink:label="loc_us-gaap_CashFlowHedgingMember_6D4B9C3CDA121D8DB6C9ED5618A92E94" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingRelationshipDomain_44CCEDD72E488D3D3479ED5618A92A9F" xlink:to="loc_us-gaap_CashFlowHedgingMember_6D4B9C3CDA121D8DB6C9ED5618A92E94" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NetInvestmentHedgingMember" xlink:label="loc_us-gaap_NetInvestmentHedgingMember_D88849F55F19041ECF42ED5618AAAC15" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingRelationshipDomain_44CCEDD72E488D3D3479ED5618A92A9F" xlink:to="loc_us-gaap_NetInvestmentHedgingMember_D88849F55F19041ECF42ED5618AAAC15" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeInstrumentRiskAxis" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_464FD4EB1BD37D70E93BED5618AABF69" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeTable_8C2248E713D5062DD0F2ED5618A6A645" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_464FD4EB1BD37D70E93BED5618AABF69" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeContractTypeDomain" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_35E8712B856FAF7EFF71ED5618AA95E4_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_464FD4EB1BD37D70E93BED5618AABF69" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_35E8712B856FAF7EFF71ED5618AA95E4_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeContractTypeDomain" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_35E8712B856FAF7EFF71ED5618AA95E4" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_464FD4EB1BD37D70E93BED5618AABF69" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_35E8712B856FAF7EFF71ED5618AA95E4" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_HedgedFixedRateDebtMember" xlink:label="loc_lly_HedgedFixedRateDebtMember_59E901BF96AE08597513ED5618AB2BA4" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_35E8712B856FAF7EFF71ED5618AA95E4" xlink:to="loc_lly_HedgedFixedRateDebtMember_59E901BF96AE08597513ED5618AB2BA4" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InterestRateContractMember" xlink:label="loc_us-gaap_InterestRateContractMember_ADA81A84587F55DFF134ED5618ABAF2C" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_35E8712B856FAF7EFF71ED5618AA95E4" xlink:to="loc_us-gaap_InterestRateContractMember_ADA81A84587F55DFF134ED5618ABAF2C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ForeignExchangeContractMember" xlink:label="loc_us-gaap_ForeignExchangeContractMember_B20FDC88E1F45C5B9FC3ED5618ABF9A8" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_35E8712B856FAF7EFF71ED5618AA95E4" xlink:to="loc_us-gaap_ForeignExchangeContractMember_B20FDC88E1F45C5B9FC3ED5618ABF9A8" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InterestRateSwapMember" xlink:label="loc_us-gaap_InterestRateSwapMember_8AA1EFE88C9BF1A293BBED5618AC8BBA" xlink:type="locator" />
    <link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_35E8712B856FAF7EFF71ED5618AA95E4" xlink:to="loc_us-gaap_InterestRateSwapMember_8AA1EFE88C9BF1A293BBED5618AC8BBA" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CrossCurrencyInterestRateContractMember" xlink:label="loc_us-gaap_CrossCurrencyInterestRateContractMember_9C8E72DB53CEDB55DFF4ED5618ACBEC4" xlink:type="locator" />
    <link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_35E8712B856FAF7EFF71ED5618AA95E4" xlink:to="loc_us-gaap_CrossCurrencyInterestRateContractMember_9C8E72DB53CEDB55DFF4ED5618ACBEC4" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_FairValueHedgeAbstract" xlink:label="loc_lly_FairValueHedgeAbstract_604CC56F16D6840A99BBED5618ACDAD4" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_743DCDB5098EE708B349ED5618ACC5E8" xlink:to="loc_lly_FairValueHedgeAbstract_604CC56F16D6840A99BBED5618ACDAD4" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ChangeInUnrealizedGainLossOnHedgedItemInFairValueHedge1" xlink:label="loc_us-gaap_ChangeInUnrealizedGainLossOnHedgedItemInFairValueHedge1_B95A66EA7E85401E69A5ED5618AD6DC9" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lly_FairValueHedgeAbstract_604CC56F16D6840A99BBED5618ACDAD4" xlink:to="loc_us-gaap_ChangeInUnrealizedGainLossOnHedgedItemInFairValueHedge1_B95A66EA7E85401E69A5ED5618AD6DC9" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ChangeInUnrealizedGainLossOnFairValueHedgingInstruments1" xlink:label="loc_us-gaap_ChangeInUnrealizedGainLossOnFairValueHedgingInstruments1_E5222EB4EC0068596E09ED5618AD5FC2" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lly_FairValueHedgeAbstract_604CC56F16D6840A99BBED5618ACDAD4" xlink:to="loc_us-gaap_ChangeInUnrealizedGainLossOnFairValueHedgingInstruments1_E5222EB4EC0068596E09ED5618AD5FC2" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_CashFlowHedgeAbstract" xlink:label="loc_lly_CashFlowHedgeAbstract_4FC9BFDA588FFBA14020ED5618AD1A7A" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_743DCDB5098EE708B349ED5618ACC5E8" xlink:to="loc_lly_CashFlowHedgeAbstract_4FC9BFDA588FFBA14020ED5618AD1A7A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossReclassificationBeforeTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossReclassificationBeforeTax_629107BDF2A0E9426632ED5618AEEB03" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lly_CashFlowHedgeAbstract_4FC9BFDA588FFBA14020ED5618AD1A7A" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossReclassificationBeforeTax_629107BDF2A0E9426632ED5618AEEB03" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeInstrumentsLossReclassifiedFromAccumulatedOCIIntoIncomeEffectivePortion" xlink:label="loc_us-gaap_DerivativeInstrumentsLossReclassifiedFromAccumulatedOCIIntoIncomeEffectivePortion_9971F957534AA585B077ED5618AE32AE" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lly_CashFlowHedgeAbstract_4FC9BFDA588FFBA14020ED5618AD1A7A" xlink:to="loc_us-gaap_DerivativeInstrumentsLossReclassifiedFromAccumulatedOCIIntoIncomeEffectivePortion_9971F957534AA585B077ED5618AE32AE" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_GainLossOnForeignCurrencyDerivativeInstrumentsNotDesignatedAsHedgingInstruments" xlink:label="loc_us-gaap_GainLossOnForeignCurrencyDerivativeInstrumentsNotDesignatedAsHedgingInstruments_50795B2A99AC65137D8FED5618AE566F" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_743DCDB5098EE708B349ED5618ACC5E8" xlink:to="loc_us-gaap_GainLossOnForeignCurrencyDerivativeInstrumentsNotDesignatedAsHedgingInstruments_50795B2A99AC65137D8FED5618AE566F" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_DerivativeInstrumentsGainLossRecognized" xlink:label="loc_lly_DerivativeInstrumentsGainLossRecognized_0B4C366CC23551A663E3ED5618AFB2D1" xlink:type="locator" />
    <link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_743DCDB5098EE708B349ED5618ACC5E8" xlink:to="loc_lly_DerivativeInstrumentsGainLossRecognized_0B4C366CC23551A663E3ED5618AFB2D1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossNetInvestmentHedgeGainLossBeforeReclassificationAndTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetInvestmentHedgeGainLossBeforeReclassificationAndTax_71B36E30B5BBC7E28BFEED5618AF9109" xlink:type="locator" />
    <link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_743DCDB5098EE708B349ED5618ACC5E8" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetInvestmentHedgeGainLossBeforeReclassificationAndTax_71B36E30B5BBC7E28BFEED5618AF9109" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAndTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAndTax_935D8DAFF481D3B2F147ED5618AF4BC6" xlink:type="locator" />
    <link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_743DCDB5098EE708B349ED5618ACC5E8" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAndTax_935D8DAFF481D3B2F147ED5618AF4BC6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherComprehensiveIncomeUnrealizedGainLossOnDerivativesArisingDuringPeriodBeforeTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeUnrealizedGainLossOnDerivativesArisingDuringPeriodBeforeTax_A1DB44B377314EF3B802ED5618AF60F6" xlink:type="locator" />
    <link:definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_743DCDB5098EE708B349ED5618ACC5E8" xlink:to="loc_us-gaap_OtherComprehensiveIncomeUnrealizedGainLossOnDerivativesArisingDuringPeriodBeforeTax_A1DB44B377314EF3B802ED5618AF60F6" xlink:type="arc" />
  </link:definitionLink>
  <link:definitionLink xlink:role="http://www.lilly.com/role/FinancialInstrumentsScheduleOfFairValueMeasurementDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems" xlink:label="loc_us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems_30D6690DEDBDB54E0440AFAA0A8F81B1" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueByBalanceSheetGroupingTable" xlink:label="loc_us-gaap_FairValueByBalanceSheetGroupingTable_5CB269390830BF02F1FDAFAA0A8A40F3" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems_30D6690DEDBDB54E0440AFAA0A8F81B1" xlink:to="loc_us-gaap_FairValueByBalanceSheetGroupingTable_5CB269390830BF02F1FDAFAA0A8A40F3" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FinancialInstrumentAxis" xlink:label="loc_us-gaap_FinancialInstrumentAxis_BC55671D67C7AEE6307DAFAA0A8A4DD8" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueByBalanceSheetGroupingTable_5CB269390830BF02F1FDAFAA0A8A40F3" xlink:to="loc_us-gaap_FinancialInstrumentAxis_BC55671D67C7AEE6307DAFAA0A8A4DD8" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_1A699D82264DAC33629EAFAA0A8B4C38_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FinancialInstrumentAxis_BC55671D67C7AEE6307DAFAA0A8A4DD8" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_1A699D82264DAC33629EAFAA0A8B4C38_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_1A699D82264DAC33629EAFAA0A8B4C38" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FinancialInstrumentAxis_BC55671D67C7AEE6307DAFAA0A8A4DD8" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_1A699D82264DAC33629EAFAA0A8B4C38" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_USGovernmentAgenciesDebtSecuritiesMember" xlink:label="loc_us-gaap_USGovernmentAgenciesDebtSecuritiesMember_A3A6E2579F8FA0E17FDBAFAA0A8B7CED" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_1A699D82264DAC33629EAFAA0A8B4C38" xlink:to="loc_us-gaap_USGovernmentAgenciesDebtSecuritiesMember_A3A6E2579F8FA0E17FDBAFAA0A8B7CED" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CorporateDebtSecuritiesMember" xlink:label="loc_us-gaap_CorporateDebtSecuritiesMember_50D7771CCAD0E17F9254AFAA0A8B6D24" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_1A699D82264DAC33629EAFAA0A8B4C38" xlink:to="loc_us-gaap_CorporateDebtSecuritiesMember_50D7771CCAD0E17F9254AFAA0A8B6D24" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AssetBackedSecuritiesMember" xlink:label="loc_us-gaap_AssetBackedSecuritiesMember_C3D0E7AB101ABBF10F16AFAA0A8C3515" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_1A699D82264DAC33629EAFAA0A8B4C38" xlink:to="loc_us-gaap_AssetBackedSecuritiesMember_C3D0E7AB101ABBF10F16AFAA0A8C3515" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherDebtSecuritiesMember" xlink:label="loc_us-gaap_OtherDebtSecuritiesMember_7AC5E67B38D668B73CEFAFAA0A8CE0F6" xlink:type="locator" />
    <link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_1A699D82264DAC33629EAFAA0A8B4C38" xlink:to="loc_us-gaap_OtherDebtSecuritiesMember_7AC5E67B38D668B73CEFAFAA0A8CE0F6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_MortgageBackedSecuritiesMember" xlink:label="loc_us-gaap_MortgageBackedSecuritiesMember_D60491D8B795FEDCAA89AFAA0A8CCC6C" xlink:type="locator" />
    <link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_1A699D82264DAC33629EAFAA0A8B4C38" xlink:to="loc_us-gaap_MortgageBackedSecuritiesMember_D60491D8B795FEDCAA89AFAA0A8CCC6C" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_OtherEquitySecuritiesMember" xlink:label="loc_lly_OtherEquitySecuritiesMember_7AD969EFDDCBE3823C5BAFAA0A8C56CA" xlink:type="locator" />
    <link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_1A699D82264DAC33629EAFAA0A8B4C38" xlink:to="loc_lly_OtherEquitySecuritiesMember_7AD969EFDDCBE3823C5BAFAA0A8C56CA" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_MarketableSecuritiesMember" xlink:label="loc_lly_MarketableSecuritiesMember_CFA6E2D6FD696C64B63DAFAA0A8C4F40" xlink:type="locator" />
    <link:definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_1A699D82264DAC33629EAFAA0A8B4C38" xlink:to="loc_lly_MarketableSecuritiesMember_CFA6E2D6FD696C64B63DAFAA0A8C4F40" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_EquityMethodAndOtherInvestmentsMember" xlink:label="loc_lly_EquityMethodAndOtherInvestmentsMember_D85EE2EB2D3CEE91D916AFAA0A8C9316" xlink:type="locator" />
    <link:definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_1A699D82264DAC33629EAFAA0A8B4C38" xlink:to="loc_lly_EquityMethodAndOtherInvestmentsMember_D85EE2EB2D3CEE91D916AFAA0A8C9316" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueByMeasurementBasisAxis" xlink:label="loc_us-gaap_FairValueByMeasurementBasisAxis_CD0E48A7EC50F9CD8242AFAA0A8C701C" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueByBalanceSheetGroupingTable_5CB269390830BF02F1FDAFAA0A8A40F3" xlink:to="loc_us-gaap_FairValueByMeasurementBasisAxis_CD0E48A7EC50F9CD8242AFAA0A8C701C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PortionAtFairValueFairValueDisclosureMember" xlink:label="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_B21E1F8709EF36692690AFAA0A8D6B76_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByMeasurementBasisAxis_CD0E48A7EC50F9CD8242AFAA0A8C701C" xlink:to="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_B21E1F8709EF36692690AFAA0A8D6B76_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueDisclosureItemAmountsDomain" xlink:label="loc_us-gaap_FairValueDisclosureItemAmountsDomain_89535F6885A723D163BCAFAA0A8D4669" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByMeasurementBasisAxis_CD0E48A7EC50F9CD8242AFAA0A8C701C" xlink:to="loc_us-gaap_FairValueDisclosureItemAmountsDomain_89535F6885A723D163BCAFAA0A8D4669" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PortionAtFairValueFairValueDisclosureMember" xlink:label="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_B21E1F8709EF36692690AFAA0A8D6B76" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueDisclosureItemAmountsDomain_89535F6885A723D163BCAFAA0A8D4669" xlink:to="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_B21E1F8709EF36692690AFAA0A8D6B76" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CarryingReportedAmountFairValueDisclosureMember" xlink:label="loc_us-gaap_CarryingReportedAmountFairValueDisclosureMember_BF3BD00001C87502D998AFAA0A8D030E" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_B21E1F8709EF36692690AFAA0A8D6B76" xlink:to="loc_us-gaap_CarryingReportedAmountFairValueDisclosureMember_BF3BD00001C87502D998AFAA0A8D030E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PortionAtOtherThanFairValueFairValueDisclosureMember" xlink:label="loc_us-gaap_PortionAtOtherThanFairValueFairValueDisclosureMember_B5F7FE3972E10884B800AFAA0A8E83A0" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_B21E1F8709EF36692690AFAA0A8D6B76" xlink:to="loc_us-gaap_PortionAtOtherThanFairValueFairValueDisclosureMember_B5F7FE3972E10884B800AFAA0A8E83A0" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EstimateOfFairValueFairValueDisclosureMember" xlink:label="loc_us-gaap_EstimateOfFairValueFairValueDisclosureMember_6EB4E152FF28C6FCCBCFAFAA0A8E4FF3" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_B21E1F8709EF36692690AFAA0A8D6B76" xlink:to="loc_us-gaap_EstimateOfFairValueFairValueDisclosureMember_6EB4E152FF28C6FCCBCFAFAA0A8E4FF3" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_8C38A102CDFCFF708174AFAA0A8EE5E9" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueByBalanceSheetGroupingTable_5CB269390830BF02F1FDAFAA0A8A40F3" xlink:to="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_8C38A102CDFCFF708174AFAA0A8EE5E9" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_6779D4E8C2F93D32CC41AFAA0A8EED57_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_8C38A102CDFCFF708174AFAA0A8EE5E9" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_6779D4E8C2F93D32CC41AFAA0A8EED57_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_6779D4E8C2F93D32CC41AFAA0A8EED57" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_8C38A102CDFCFF708174AFAA0A8EE5E9" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_6779D4E8C2F93D32CC41AFAA0A8EED57" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueInputsLevel1Member" xlink:label="loc_us-gaap_FairValueInputsLevel1Member_0B6F0AEE3110B939BFCBAFAA0A8E8E47" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_6779D4E8C2F93D32CC41AFAA0A8EED57" xlink:to="loc_us-gaap_FairValueInputsLevel1Member_0B6F0AEE3110B939BFCBAFAA0A8E8E47" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueInputsLevel2Member" xlink:label="loc_us-gaap_FairValueInputsLevel2Member_5837D4B4921B92271574AFAA0A8FAFE4" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_6779D4E8C2F93D32CC41AFAA0A8EED57" xlink:to="loc_us-gaap_FairValueInputsLevel2Member_5837D4B4921B92271574AFAA0A8FAFE4" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueInputsLevel3Member" xlink:label="loc_us-gaap_FairValueInputsLevel3Member_3C282B4356D287301E80AFAA0A8F46F2" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_6779D4E8C2F93D32CC41AFAA0A8EED57" xlink:to="loc_us-gaap_FairValueInputsLevel3Member_3C282B4356D287301E80AFAA0A8F46F2" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CashAndCashEquivalentsFairValueDisclosure" xlink:label="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_884B7C0E6C9AF294D2AEAFAA0A8FCDD0" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems_30D6690DEDBDB54E0440AFAA0A8F81B1" xlink:to="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_884B7C0E6C9AF294D2AEAFAA0A8FCDD0" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleSaleAbstract" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleSaleAbstract_FFD70BC99AE849D16428AFAA0A8F89E1" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems_30D6690DEDBDB54E0440AFAA0A8F81B1" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleSaleAbstract_FFD70BC99AE849D16428AFAA0A8F89E1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent_4DDF5DA0D7A822E32353AFAA0A909AA0" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleSaleAbstract_FFD70BC99AE849D16428AFAA0A8F89E1" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent_4DDF5DA0D7A822E32353AFAA0A909AA0" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AvailableForSaleSecuritiesAbstract" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesAbstract_6A01D7CE422A0CC05F2BAFAA0A9026F3" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems_30D6690DEDBDB54E0440AFAA0A8F81B1" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesAbstract_6A01D7CE422A0CC05F2BAFAA0A9026F3" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecuritiesNoncurrent" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesNoncurrent_BB42E105F8DFC2EE58D6AFAA0A90285F" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesAbstract_6A01D7CE422A0CC05F2BAFAA0A9026F3" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesNoncurrent_BB42E105F8DFC2EE58D6AFAA0A90285F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EquitySecuritiesFvNi" xlink:label="loc_us-gaap_EquitySecuritiesFvNi_243C7F6C385867D918B9AFAA0A9109B0" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesAbstract_6A01D7CE422A0CC05F2BAFAA0A9026F3" xlink:to="loc_us-gaap_EquitySecuritiesFvNi_243C7F6C385867D918B9AFAA0A9109B0" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EquitySecuritiesWithoutReadilyDeterminableFairValueAmount" xlink:label="loc_us-gaap_EquitySecuritiesWithoutReadilyDeterminableFairValueAmount_11168EC1D7B05838ADC0AFAA0A9129F0" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesAbstract_6A01D7CE422A0CC05F2BAFAA0A9026F3" xlink:to="loc_us-gaap_EquitySecuritiesWithoutReadilyDeterminableFairValueAmount_11168EC1D7B05838ADC0AFAA0A9129F0" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherLongTermInvestments" xlink:label="loc_us-gaap_OtherLongTermInvestments_35511516522127EC240BAFAA0A9106B2" xlink:type="locator" />
    <link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesAbstract_6A01D7CE422A0CC05F2BAFAA0A9026F3" xlink:to="loc_us-gaap_OtherLongTermInvestments_35511516522127EC240BAFAA0A9106B2" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LongTermInvestments" xlink:label="loc_us-gaap_LongTermInvestments_73F2FECB59B3357AD371AFAA0A91138F" xlink:type="locator" />
    <link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesAbstract_6A01D7CE422A0CC05F2BAFAA0A9026F3" xlink:to="loc_us-gaap_LongTermInvestments_73F2FECB59B3357AD371AFAA0A91138F" xlink:type="arc" />
  </link:definitionLink>
  <link:definitionLink xlink:role="http://www.lilly.com/role/FinancialInstrumentsScheduleOfInvestmentPortfolioActivityDetails" xlink:type="extended" />
  <link:definitionLink xlink:role="http://www.lilly.com/role/FinancialInstrumentsScheduleOfRiskManagementInstrumentsDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_F433648CFE894A0EC5F1F75EE78914D2" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_965DDEF8A79FB7F5458AF75EE78363AE" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_F433648CFE894A0EC5F1F75EE78914D2" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_965DDEF8A79FB7F5458AF75EE78363AE" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis" xlink:label="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_1BD1B3AFC89D442E2696F75EE784E1C2" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_965DDEF8A79FB7F5458AF75EE78363AE" xlink:to="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_1BD1B3AFC89D442E2696F75EE784E1C2" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_HedgingRelationshipDomain" xlink:label="loc_us-gaap_HedgingRelationshipDomain_38E91DEAD15431E6E280F75EE784E821_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_1BD1B3AFC89D442E2696F75EE784E1C2" xlink:to="loc_us-gaap_HedgingRelationshipDomain_38E91DEAD15431E6E280F75EE784E821_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_HedgingRelationshipDomain" xlink:label="loc_us-gaap_HedgingRelationshipDomain_38E91DEAD15431E6E280F75EE784E821" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_1BD1B3AFC89D442E2696F75EE784E1C2" xlink:to="loc_us-gaap_HedgingRelationshipDomain_38E91DEAD15431E6E280F75EE784E821" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueHedgingMember" xlink:label="loc_us-gaap_FairValueHedgingMember_44F5D58D86F834773654F75EE7848E11" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingRelationshipDomain_38E91DEAD15431E6E280F75EE784E821" xlink:to="loc_us-gaap_FairValueHedgingMember_44F5D58D86F834773654F75EE7848E11" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CashFlowHedgingMember" xlink:label="loc_us-gaap_CashFlowHedgingMember_9B994D67FC62A9968B7BF75EE785398C" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingRelationshipDomain_38E91DEAD15431E6E280F75EE784E821" xlink:to="loc_us-gaap_CashFlowHedgingMember_9B994D67FC62A9968B7BF75EE785398C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NetInvestmentHedgingMember" xlink:label="loc_us-gaap_NetInvestmentHedgingMember_091032798EE8696E7A03F75EE78543E5" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingRelationshipDomain_38E91DEAD15431E6E280F75EE784E821" xlink:to="loc_us-gaap_NetInvestmentHedgingMember_091032798EE8696E7A03F75EE78543E5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueByMeasurementBasisAxis" xlink:label="loc_us-gaap_FairValueByMeasurementBasisAxis_E6FC4D106ACE3CF6FA7FF75EE7856BD5" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_965DDEF8A79FB7F5458AF75EE78363AE" xlink:to="loc_us-gaap_FairValueByMeasurementBasisAxis_E6FC4D106ACE3CF6FA7FF75EE7856BD5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PortionAtFairValueFairValueDisclosureMember" xlink:label="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_888C72B953B1F053C0E9F75EE7858876_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByMeasurementBasisAxis_E6FC4D106ACE3CF6FA7FF75EE7856BD5" xlink:to="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_888C72B953B1F053C0E9F75EE7858876_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueDisclosureItemAmountsDomain" xlink:label="loc_us-gaap_FairValueDisclosureItemAmountsDomain_131111E19237E66A39B6F75EE785817E" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByMeasurementBasisAxis_E6FC4D106ACE3CF6FA7FF75EE7856BD5" xlink:to="loc_us-gaap_FairValueDisclosureItemAmountsDomain_131111E19237E66A39B6F75EE785817E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PortionAtFairValueFairValueDisclosureMember" xlink:label="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_888C72B953B1F053C0E9F75EE7858876" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueDisclosureItemAmountsDomain_131111E19237E66A39B6F75EE785817E" xlink:to="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_888C72B953B1F053C0E9F75EE7858876" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CarryingReportedAmountFairValueDisclosureMember" xlink:label="loc_us-gaap_CarryingReportedAmountFairValueDisclosureMember_F3E1E7E2D31C666C263EF75EE7869AC1" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_888C72B953B1F053C0E9F75EE7858876" xlink:to="loc_us-gaap_CarryingReportedAmountFairValueDisclosureMember_F3E1E7E2D31C666C263EF75EE7869AC1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EstimateOfFairValueFairValueDisclosureMember" xlink:label="loc_us-gaap_EstimateOfFairValueFairValueDisclosureMember_ABF516B73F1D1AA67F4EF75EE7864B49" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_888C72B953B1F053C0E9F75EE7858876" xlink:to="loc_us-gaap_EstimateOfFairValueFairValueDisclosureMember_ABF516B73F1D1AA67F4EF75EE7864B49" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_HedgingDesignationAxis" xlink:label="loc_us-gaap_HedgingDesignationAxis_6FA2E33E4B6255FAAC6EF75EE7864436" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_965DDEF8A79FB7F5458AF75EE78363AE" xlink:to="loc_us-gaap_HedgingDesignationAxis_6FA2E33E4B6255FAAC6EF75EE7864436" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_HedgingDesignationDomain" xlink:label="loc_us-gaap_HedgingDesignationDomain_71FE182097D18B122E97F75EE786EAC5_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_HedgingDesignationAxis_6FA2E33E4B6255FAAC6EF75EE7864436" xlink:to="loc_us-gaap_HedgingDesignationDomain_71FE182097D18B122E97F75EE786EAC5_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_HedgingDesignationDomain" xlink:label="loc_us-gaap_HedgingDesignationDomain_71FE182097D18B122E97F75EE786EAC5" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_HedgingDesignationAxis_6FA2E33E4B6255FAAC6EF75EE7864436" xlink:to="loc_us-gaap_HedgingDesignationDomain_71FE182097D18B122E97F75EE786EAC5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DesignatedAsHedgingInstrumentMember" xlink:label="loc_us-gaap_DesignatedAsHedgingInstrumentMember_BC5B940278C8184774DBF75EE7877C9C" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingDesignationDomain_71FE182097D18B122E97F75EE786EAC5" xlink:to="loc_us-gaap_DesignatedAsHedgingInstrumentMember_BC5B940278C8184774DBF75EE7877C9C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NondesignatedMember" xlink:label="loc_us-gaap_NondesignatedMember_05D7F59802FA3B91AD6AF75EE7874CFB" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingDesignationDomain_71FE182097D18B122E97F75EE786EAC5" xlink:to="loc_us-gaap_NondesignatedMember_05D7F59802FA3B91AD6AF75EE7874CFB" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeInstrumentRiskAxis" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_0B8844AB3C6CE8C1F01EF75EE787E350" xlink:type="locator" />
    <link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_965DDEF8A79FB7F5458AF75EE78363AE" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_0B8844AB3C6CE8C1F01EF75EE787E350" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeContractTypeDomain" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_F1F20B8C39396B56F17BF75EE7876D62_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_0B8844AB3C6CE8C1F01EF75EE787E350" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_F1F20B8C39396B56F17BF75EE7876D62_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeContractTypeDomain" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_F1F20B8C39396B56F17BF75EE7876D62" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_0B8844AB3C6CE8C1F01EF75EE787E350" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_F1F20B8C39396B56F17BF75EE7876D62" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InterestRateContractMember" xlink:label="loc_us-gaap_InterestRateContractMember_57308690ACF02F347CF7F75EE78862EB" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_F1F20B8C39396B56F17BF75EE7876D62" xlink:to="loc_us-gaap_InterestRateContractMember_57308690ACF02F347CF7F75EE78862EB" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CrossCurrencyInterestRateContractMember" xlink:label="loc_us-gaap_CrossCurrencyInterestRateContractMember_C0DA1B1BDA4B0BD941F8F75EE788D669" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_F1F20B8C39396B56F17BF75EE7876D62" xlink:to="loc_us-gaap_CrossCurrencyInterestRateContractMember_C0DA1B1BDA4B0BD941F8F75EE788D669" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ForeignExchangeContractMember" xlink:label="loc_us-gaap_ForeignExchangeContractMember_20C8131F5377820C9E8EF75EE7888151" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_F1F20B8C39396B56F17BF75EE7876D62" xlink:to="loc_us-gaap_ForeignExchangeContractMember_20C8131F5377820C9E8EF75EE7888151" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_7D2A8CACDDC60F7EAB7FF75EE788FD24" xlink:type="locator" />
    <link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_965DDEF8A79FB7F5458AF75EE78363AE" xlink:to="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_7D2A8CACDDC60F7EAB7FF75EE788FD24" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_FF2ACD9E02EF11DAAFC2F75EE7897DB9_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_7D2A8CACDDC60F7EAB7FF75EE788FD24" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_FF2ACD9E02EF11DAAFC2F75EE7897DB9_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_FF2ACD9E02EF11DAAFC2F75EE7897DB9" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_7D2A8CACDDC60F7EAB7FF75EE788FD24" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_FF2ACD9E02EF11DAAFC2F75EE7897DB9" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueInputsLevel1Member" xlink:label="loc_us-gaap_FairValueInputsLevel1Member_F591CA840E20A57515E8F75EE7894A63" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_FF2ACD9E02EF11DAAFC2F75EE7897DB9" xlink:to="loc_us-gaap_FairValueInputsLevel1Member_F591CA840E20A57515E8F75EE7894A63" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueInputsLevel2Member" xlink:label="loc_us-gaap_FairValueInputsLevel2Member_CDBC2531EB87847EBF0BF75EE7894395" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_FF2ACD9E02EF11DAAFC2F75EE7897DB9" xlink:to="loc_us-gaap_FairValueInputsLevel2Member_CDBC2531EB87847EBF0BF75EE7894395" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueInputsLevel3Member" xlink:label="loc_us-gaap_FairValueInputsLevel3Member_3D80BB21FE521614B18DF75EE7893AC8" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_FF2ACD9E02EF11DAAFC2F75EE7897DB9" xlink:to="loc_us-gaap_FairValueInputsLevel3Member_3D80BB21FE521614B18DF75EE7893AC8" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeAssetsNoncurrent" xlink:label="loc_us-gaap_DerivativeAssetsNoncurrent_529EE4DB51A801970460F75EE7898511" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_F433648CFE894A0EC5F1F75EE78914D2" xlink:to="loc_us-gaap_DerivativeAssetsNoncurrent_529EE4DB51A801970460F75EE7898511" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeAssetsCurrent" xlink:label="loc_us-gaap_DerivativeAssetsCurrent_04EC6523A50D2B1A8653F75EE78A8A71" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_F433648CFE894A0EC5F1F75EE78914D2" xlink:to="loc_us-gaap_DerivativeAssetsCurrent_04EC6523A50D2B1A8653F75EE78A8A71" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeLiabilitiesCurrent" xlink:label="loc_us-gaap_DerivativeLiabilitiesCurrent_48CCBBA5D0FE9022574AF75EE78A5AB2" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_F433648CFE894A0EC5F1F75EE78914D2" xlink:to="loc_us-gaap_DerivativeLiabilitiesCurrent_48CCBBA5D0FE9022574AF75EE78A5AB2" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeLiabilitiesNoncurrent" xlink:label="loc_us-gaap_DerivativeLiabilitiesNoncurrent_DDD16BF109C1220470E3F75EE78AC2A8" xlink:type="locator" />
    <link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_F433648CFE894A0EC5F1F75EE78914D2" xlink:to="loc_us-gaap_DerivativeLiabilitiesNoncurrent_DDD16BF109C1220470E3F75EE78AC2A8" xlink:type="arc" />
  </link:definitionLink>
  <link:definitionLink xlink:role="http://www.lilly.com/role/FinancialInstrumentsScheduleOfShortTermAndLongTermClassificationDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationLineItems" xlink:label="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationLineItems_E4E3EECD90CB4FE08E0DAFA5D2216871" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTable" xlink:label="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTable_A9516098FD8F5441AFDCAFA5D21EC82B" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationLineItems_E4E3EECD90CB4FE08E0DAFA5D2216871" xlink:to="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTable_A9516098FD8F5441AFDCAFA5D21EC82B" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShortTermDebtTypeAxis" xlink:label="loc_us-gaap_ShortTermDebtTypeAxis_AD9D3642463B763A5962AFA5D21E09DA" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTable_A9516098FD8F5441AFDCAFA5D21EC82B" xlink:to="loc_us-gaap_ShortTermDebtTypeAxis_AD9D3642463B763A5962AFA5D21E09DA" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShortTermDebtTypeDomain" xlink:label="loc_us-gaap_ShortTermDebtTypeDomain_931355C15E7D7741F646AFA5D21E771E_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ShortTermDebtTypeAxis_AD9D3642463B763A5962AFA5D21E09DA" xlink:to="loc_us-gaap_ShortTermDebtTypeDomain_931355C15E7D7741F646AFA5D21E771E_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShortTermDebtTypeDomain" xlink:label="loc_us-gaap_ShortTermDebtTypeDomain_931355C15E7D7741F646AFA5D21E771E" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ShortTermDebtTypeAxis_AD9D3642463B763A5962AFA5D21E09DA" xlink:to="loc_us-gaap_ShortTermDebtTypeDomain_931355C15E7D7741F646AFA5D21E771E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CommercialPaperMember" xlink:label="loc_us-gaap_CommercialPaperMember_87F9A6AABAEB0D68C03CAFA5D21FF7C9" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShortTermDebtTypeDomain_931355C15E7D7741F646AFA5D21E771E" xlink:to="loc_us-gaap_CommercialPaperMember_87F9A6AABAEB0D68C03CAFA5D21FF7C9" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_FC170576C687AD1B8437AFA5D21FBE3A" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTable_A9516098FD8F5441AFDCAFA5D21EC82B" xlink:to="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_FC170576C687AD1B8437AFA5D21FBE3A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_C4F04E54548EBAFB563DAFA5D21F93BB_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_FC170576C687AD1B8437AFA5D21FBE3A" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_C4F04E54548EBAFB563DAFA5D21F93BB_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_C4F04E54548EBAFB563DAFA5D21F93BB" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_FC170576C687AD1B8437AFA5D21FBE3A" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_C4F04E54548EBAFB563DAFA5D21F93BB" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueInputsLevel1Member" xlink:label="loc_us-gaap_FairValueInputsLevel1Member_B087BAAA1ADAC6E840ECAFA5D21F794A" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_C4F04E54548EBAFB563DAFA5D21F93BB" xlink:to="loc_us-gaap_FairValueInputsLevel1Member_B087BAAA1ADAC6E840ECAFA5D21F794A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueInputsLevel2Member" xlink:label="loc_us-gaap_FairValueInputsLevel2Member_785E31190B9CB3FA4BC1AFA5D2206F9F" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_C4F04E54548EBAFB563DAFA5D21F93BB" xlink:to="loc_us-gaap_FairValueInputsLevel2Member_785E31190B9CB3FA4BC1AFA5D2206F9F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueInputsLevel3Member" xlink:label="loc_us-gaap_FairValueInputsLevel3Member_D106F4CB1F4B9E18A795AFA5D2201121" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_C4F04E54548EBAFB563DAFA5D21F93BB" xlink:to="loc_us-gaap_FairValueInputsLevel3Member_D106F4CB1F4B9E18A795AFA5D2201121" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueByMeasurementBasisAxis" xlink:label="loc_us-gaap_FairValueByMeasurementBasisAxis_EFC43A34B80DF142CC24AFA5D220B41C" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTable_A9516098FD8F5441AFDCAFA5D21EC82B" xlink:to="loc_us-gaap_FairValueByMeasurementBasisAxis_EFC43A34B80DF142CC24AFA5D220B41C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PortionAtFairValueFairValueDisclosureMember" xlink:label="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_26D29031B7FCFB2C866BAFA5D22099E6_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByMeasurementBasisAxis_EFC43A34B80DF142CC24AFA5D220B41C" xlink:to="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_26D29031B7FCFB2C866BAFA5D22099E6_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueDisclosureItemAmountsDomain" xlink:label="loc_us-gaap_FairValueDisclosureItemAmountsDomain_8252FE60990683BF3690AFA5D2207E93" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByMeasurementBasisAxis_EFC43A34B80DF142CC24AFA5D220B41C" xlink:to="loc_us-gaap_FairValueDisclosureItemAmountsDomain_8252FE60990683BF3690AFA5D2207E93" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PortionAtFairValueFairValueDisclosureMember" xlink:label="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_26D29031B7FCFB2C866BAFA5D22099E6" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueDisclosureItemAmountsDomain_8252FE60990683BF3690AFA5D2207E93" xlink:to="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_26D29031B7FCFB2C866BAFA5D22099E6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CarryingReportedAmountFairValueDisclosureMember" xlink:label="loc_us-gaap_CarryingReportedAmountFairValueDisclosureMember_81ACAFC41B09D851DC8FAFA5D22114F2" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_26D29031B7FCFB2C866BAFA5D22099E6" xlink:to="loc_us-gaap_CarryingReportedAmountFairValueDisclosureMember_81ACAFC41B09D851DC8FAFA5D22114F2" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EstimateOfFairValueFairValueDisclosureMember" xlink:label="loc_us-gaap_EstimateOfFairValueFairValueDisclosureMember_39D8A445DE3B63571C5DAFA5D221D580" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_26D29031B7FCFB2C866BAFA5D22099E6" xlink:to="loc_us-gaap_EstimateOfFairValueFairValueDisclosureMember_39D8A445DE3B63571C5DAFA5D221D580" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CommercialPaper" xlink:label="loc_us-gaap_CommercialPaper_957BE7BAA6021DEC6FCBAFA5D2219A25" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationLineItems_E4E3EECD90CB4FE08E0DAFA5D2216871" xlink:to="loc_us-gaap_CommercialPaper_957BE7BAA6021DEC6FCBAFA5D2219A25" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LongTermDebt" xlink:label="loc_us-gaap_LongTermDebt_89F18FEA0EB744D345F9AFA5D2221A64" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationLineItems_E4E3EECD90CB4FE08E0DAFA5D2216871" xlink:to="loc_us-gaap_LongTermDebt_89F18FEA0EB744D345F9AFA5D2221A64" xlink:type="arc" />
  </link:definitionLink>
  <link:definitionLink xlink:role="http://www.lilly.com/role/FinancialInstrumentsTables" xlink:type="extended" />
  <link:definitionLink xlink:role="http://www.lilly.com/role/GoodwillAndOtherIntangibles" xlink:type="extended" />
  <link:definitionLink xlink:role="http://www.lilly.com/role/GoodwillAndOtherIntangiblesNarrativeDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsLineItems" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_DD75F2C800A37E6DFBEF36C0EA57C3B8" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable" xlink:label="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_CBF90422063B1D14702C36C0EA55DAB9" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_DD75F2C800A37E6DFBEF36C0EA57C3B8" xlink:to="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_CBF90422063B1D14702C36C0EA55DAB9" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_RangeAxis" xlink:label="loc_srt_RangeAxis_2AAD2A16A908E9399BFC370488528B13" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_CBF90422063B1D14702C36C0EA55DAB9" xlink:to="loc_srt_RangeAxis_2AAD2A16A908E9399BFC370488528B13" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_RangeMember" xlink:label="loc_srt_RangeMember_74A27C8ED4CFD76EDAD23704885D1D84_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_2AAD2A16A908E9399BFC370488528B13" xlink:to="loc_srt_RangeMember_74A27C8ED4CFD76EDAD23704885D1D84_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_RangeMember" xlink:label="loc_srt_RangeMember_74A27C8ED4CFD76EDAD23704885D1D84" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_2AAD2A16A908E9399BFC370488528B13" xlink:to="loc_srt_RangeMember_74A27C8ED4CFD76EDAD23704885D1D84" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_MinimumMember" xlink:label="loc_srt_MinimumMember_D213F10FF504E60A3F3B3704AFC755DC" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_74A27C8ED4CFD76EDAD23704885D1D84" xlink:to="loc_srt_MinimumMember_D213F10FF504E60A3F3B3704AFC755DC" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_MaximumMember" xlink:label="loc_srt_MaximumMember_B4D9454D9B58C034F97D3704886DA52A" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_74A27C8ED4CFD76EDAD23704885D1D84" xlink:to="loc_srt_MaximumMember_B4D9454D9B58C034F97D3704886DA52A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_GoodwillImpairmentLoss" xlink:label="loc_us-gaap_GoodwillImpairmentLoss_9071636FE35086B410FF36C0EA5758D0" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_DD75F2C800A37E6DFBEF36C0EA57C3B8" xlink:to="loc_us-gaap_GoodwillImpairmentLoss_9071636FE35086B410FF36C0EA5758D0" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetUsefulLife" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetUsefulLife_9383F0EE6C0F9CAAF05836C0EA57D5CB" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_DD75F2C800A37E6DFBEF36C0EA57C3B8" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetUsefulLife_9383F0EE6C0F9CAAF05836C0EA57D5CB" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsRemainingAmortizationPeriod1" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsRemainingAmortizationPeriod1_952180D8B5C6C5A21C1336C0EA58EDAB" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_DD75F2C800A37E6DFBEF36C0EA57C3B8" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsRemainingAmortizationPeriod1_952180D8B5C6C5A21C1336C0EA58EDAB" xlink:type="arc" />
  </link:definitionLink>
  <link:definitionLink xlink:role="http://www.lilly.com/role/GoodwillAndOtherIntangiblesPolicies" xlink:type="extended" />
  <link:definitionLink xlink:role="http://www.lilly.com/role/GoodwillAndOtherIntangiblesScheduleOfAmortizationExpenseDetails" xlink:type="extended" />
  <link:definitionLink xlink:role="http://www.lilly.com/role/GoodwillAndOtherIntangiblesScheduleOfEstimatedAmortizationExpenseDetails" xlink:type="extended" />
  <link:definitionLink xlink:role="http://www.lilly.com/role/GoodwillAndOtherIntangiblesScheduleOfFiniteLivedAndIndefiniteLivedIntangibleAssetsOtherThanGoodwillDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsLineItems" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_6BF25EC30043F48E87B95972FBDB8476" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable" xlink:label="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_89EF81CD6FFA0F3DFC3B5972FBDA4BBE" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_6BF25EC30043F48E87B95972FBDB8476" xlink:to="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_89EF81CD6FFA0F3DFC3B5972FBDA4BBE" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_0C01D226FFB2E334A8795972FBDAEDFB" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_89EF81CD6FFA0F3DFC3B5972FBDA4BBE" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_0C01D226FFB2E334A8795972FBDAEDFB" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_62925D5477A6B6ED097A5972FBDA0A24_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_0C01D226FFB2E334A8795972FBDAEDFB" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_62925D5477A6B6ED097A5972FBDA0A24_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_62925D5477A6B6ED097A5972FBDA0A24" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_0C01D226FFB2E334A8795972FBDAEDFB" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_62925D5477A6B6ED097A5972FBDA0A24" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DevelopedTechnologyRightsMember" xlink:label="loc_us-gaap_DevelopedTechnologyRightsMember_5E35FED7750216DD8FA65972FBDBD59F" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_62925D5477A6B6ED097A5972FBDA0A24" xlink:to="loc_us-gaap_DevelopedTechnologyRightsMember_5E35FED7750216DD8FA65972FBDBD59F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherIntangibleAssetsMember" xlink:label="loc_us-gaap_OtherIntangibleAssetsMember_E7D45C86E5ED77DEBEE95972FBDBA604" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_62925D5477A6B6ED097A5972FBDA0A24" xlink:to="loc_us-gaap_OtherIntangibleAssetsMember_E7D45C86E5ED77DEBEE95972FBDBA604" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsGross" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsGross_62E7CF2BE9E0F7BA39815972FBDBD494" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_6BF25EC30043F48E87B95972FBDB8476" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsGross_62E7CF2BE9E0F7BA39815972FBDBD494" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_05B38FF85439F24398A95972FBDCAB37" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_6BF25EC30043F48E87B95972FBDB8476" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_05B38FF85439F24398A95972FBDCAB37" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsNet" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_B1E7CC4C2CB613A71F295972FBDC1982" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_6BF25EC30043F48E87B95972FBDB8476" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsNet_B1E7CC4C2CB613A71F295972FBDC1982" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassLineItems" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassLineItems_8DDB109F030AAF2685CD5972FBDE77BB" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfIndefiniteLivedIntangibleAssetsTable" xlink:label="loc_us-gaap_ScheduleOfIndefiniteLivedIntangibleAssetsTable_E8EB87D499D7D897F7DC5972FBDC1506" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassLineItems_8DDB109F030AAF2685CD5972FBDE77BB" xlink:to="loc_us-gaap_ScheduleOfIndefiniteLivedIntangibleAssetsTable_E8EB87D499D7D897F7DC5972FBDC1506" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis_187E9C1D93BCDB41AB105972FBDD502E" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfIndefiniteLivedIntangibleAssetsTable_E8EB87D499D7D897F7DC5972FBDC1506" xlink:to="loc_us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis_187E9C1D93BCDB41AB105972FBDD502E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain_C075395F046F42F040745972FBDD5E06_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis_187E9C1D93BCDB41AB105972FBDD502E" xlink:to="loc_us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain_C075395F046F42F040745972FBDD5E06_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain_C075395F046F42F040745972FBDD5E06" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis_187E9C1D93BCDB41AB105972FBDD502E" xlink:to="loc_us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain_C075395F046F42F040745972FBDD5E06" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InProcessResearchAndDevelopmentMember" xlink:label="loc_us-gaap_InProcessResearchAndDevelopmentMember_D4E3DE36B265E2BC81D45972FBDDAFCC" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain_C075395F046F42F040745972FBDD5E06" xlink:to="loc_us-gaap_InProcessResearchAndDevelopmentMember_D4E3DE36B265E2BC81D45972FBDDAFCC" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherIntangibleAssetsMember" xlink:label="loc_us-gaap_OtherIntangibleAssetsMember_E8789229F215486BD1625972FBDD91ED" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain_C075395F046F42F040745972FBDD5E06" xlink:to="loc_us-gaap_OtherIntangibleAssetsMember_E8789229F215486BD1625972FBDD91ED" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill_15064A595E39B0267A1E5972FBDEE2AF" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassLineItems_8DDB109F030AAF2685CD5972FBDE77BB" xlink:to="loc_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill_15064A595E39B0267A1E5972FBDEE2AF" xlink:type="arc" />
  </link:definitionLink>
  <link:definitionLink xlink:role="http://www.lilly.com/role/GoodwillAndOtherIntangiblesTables" xlink:type="extended" />
  <link:definitionLink xlink:role="http://www.lilly.com/role/IncomeTaxes" xlink:type="extended" />
  <link:definitionLink xlink:role="http://www.lilly.com/role/IncomeTaxesNarrativeDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OperatingLossCarryforwardsLineItems" xlink:label="loc_us-gaap_OperatingLossCarryforwardsLineItems_128EECF04E90CCACEFE636BEFB443F22" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OperatingLossCarryforwardsTable" xlink:label="loc_us-gaap_OperatingLossCarryforwardsTable_CE77A113A67D015D95B736BEFB3F1616" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_OperatingLossCarryforwardsLineItems_128EECF04E90CCACEFE636BEFB443F22" xlink:to="loc_us-gaap_OperatingLossCarryforwardsTable_CE77A113A67D015D95B736BEFB3F1616" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_TaxPeriodAxis" xlink:label="loc_us-gaap_TaxPeriodAxis_CC21C222D1F9E566FCA436BEFB3F662E" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_OperatingLossCarryforwardsTable_CE77A113A67D015D95B736BEFB3F1616" xlink:to="loc_us-gaap_TaxPeriodAxis_CC21C222D1F9E566FCA436BEFB3F662E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_TaxPeriodDomain" xlink:label="loc_us-gaap_TaxPeriodDomain_CF68624580E6C227790B36BEFB402317_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_TaxPeriodAxis_CC21C222D1F9E566FCA436BEFB3F662E" xlink:to="loc_us-gaap_TaxPeriodDomain_CF68624580E6C227790B36BEFB402317_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_TaxPeriodDomain" xlink:label="loc_us-gaap_TaxPeriodDomain_CF68624580E6C227790B36BEFB402317" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_TaxPeriodAxis_CC21C222D1F9E566FCA436BEFB3F662E" xlink:to="loc_us-gaap_TaxPeriodDomain_CF68624580E6C227790B36BEFB402317" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_TaxYears2013To2015Member" xlink:label="loc_lly_TaxYears2013To2015Member_48F7D6A146217D74DC6536BEFB406602" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TaxPeriodDomain_CF68624580E6C227790B36BEFB402317" xlink:to="loc_lly_TaxYears2013To2015Member_48F7D6A146217D74DC6536BEFB406602" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_TaxCreditCarryforwardAxis" xlink:label="loc_us-gaap_TaxCreditCarryforwardAxis_680E2505003E0D46B9FE36BEFB408B14" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_OperatingLossCarryforwardsTable_CE77A113A67D015D95B736BEFB3F1616" xlink:to="loc_us-gaap_TaxCreditCarryforwardAxis_680E2505003E0D46B9FE36BEFB408B14" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_TaxCreditCarryforwardNameDomain" xlink:label="loc_us-gaap_TaxCreditCarryforwardNameDomain_535A0EE299DBB4B9692E36BEFB41D41D_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_TaxCreditCarryforwardAxis_680E2505003E0D46B9FE36BEFB408B14" xlink:to="loc_us-gaap_TaxCreditCarryforwardNameDomain_535A0EE299DBB4B9692E36BEFB41D41D_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_TaxCreditCarryforwardNameDomain" xlink:label="loc_us-gaap_TaxCreditCarryforwardNameDomain_535A0EE299DBB4B9692E36BEFB41D41D" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_TaxCreditCarryforwardAxis_680E2505003E0D46B9FE36BEFB408B14" xlink:to="loc_us-gaap_TaxCreditCarryforwardNameDomain_535A0EE299DBB4B9692E36BEFB41D41D" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_CarryforwardMember" xlink:label="loc_lly_CarryforwardMember_7F65CEB485A8A11BCB0936BEFB41EB97" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TaxCreditCarryforwardNameDomain_535A0EE299DBB4B9692E36BEFB41D41D" xlink:to="loc_lly_CarryforwardMember_7F65CEB485A8A11BCB0936BEFB41EB97" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_Expirationin6YearsMember" xlink:label="loc_lly_Expirationin6YearsMember_76971D7571137E351FD236BEFB417254" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TaxCreditCarryforwardNameDomain_535A0EE299DBB4B9692E36BEFB41D41D" xlink:to="loc_lly_Expirationin6YearsMember_76971D7571137E351FD236BEFB417254" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_ExpirationIn12To18YearsMember" xlink:label="loc_lly_ExpirationIn12To18YearsMember_0C213411BB1C51BDF23B36BEFB41D331" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TaxCreditCarryforwardNameDomain_535A0EE299DBB4B9692E36BEFB41D41D" xlink:to="loc_lly_ExpirationIn12To18YearsMember_0C213411BB1C51BDF23B36BEFB41D331" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_DesignatedUnusableMember" xlink:label="loc_lly_DesignatedUnusableMember_C6C376FB7517F7DF209C36BEFB4294C4" xlink:type="locator" />
    <link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TaxCreditCarryforwardNameDomain_535A0EE299DBB4B9692E36BEFB41D41D" xlink:to="loc_lly_DesignatedUnusableMember_C6C376FB7517F7DF209C36BEFB4294C4" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_Expirationwithin5yearsMember" xlink:label="loc_lly_Expirationwithin5yearsMember_85C9D9302BD7DD9D3DEB36BEFB42D4F5" xlink:type="locator" />
    <link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TaxCreditCarryforwardNameDomain_535A0EE299DBB4B9692E36BEFB41D41D" xlink:to="loc_lly_Expirationwithin5yearsMember_85C9D9302BD7DD9D3DEB36BEFB42D4F5" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_Expiration5to20YearsMember" xlink:label="loc_lly_Expiration5to20YearsMember_8FF5ECA8B5B9032AD3B836BEFB42F42C" xlink:type="locator" />
    <link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TaxCreditCarryforwardNameDomain_535A0EE299DBB4B9692E36BEFB41D41D" xlink:to="loc_lly_Expiration5to20YearsMember_8FF5ECA8B5B9032AD3B836BEFB42F42C" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_NoExpirationMember" xlink:label="loc_lly_NoExpirationMember_16FC65B54333AE162AE036BEFB425388" xlink:type="locator" />
    <link:definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TaxCreditCarryforwardNameDomain_535A0EE299DBB4B9692E36BEFB41D41D" xlink:to="loc_lly_NoExpirationMember_16FC65B54333AE162AE036BEFB425388" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeTaxAuthorityAxis" xlink:label="loc_us-gaap_IncomeTaxAuthorityAxis_9C80B8DF00BFC452494B36BEFB420DD0" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_OperatingLossCarryforwardsTable_CE77A113A67D015D95B736BEFB3F1616" xlink:to="loc_us-gaap_IncomeTaxAuthorityAxis_9C80B8DF00BFC452494B36BEFB420DD0" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeTaxAuthorityDomain" xlink:label="loc_us-gaap_IncomeTaxAuthorityDomain_288BBC3EADF84261E74E36BEFB433937_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_IncomeTaxAuthorityAxis_9C80B8DF00BFC452494B36BEFB420DD0" xlink:to="loc_us-gaap_IncomeTaxAuthorityDomain_288BBC3EADF84261E74E36BEFB433937_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeTaxAuthorityDomain" xlink:label="loc_us-gaap_IncomeTaxAuthorityDomain_288BBC3EADF84261E74E36BEFB433937" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_IncomeTaxAuthorityAxis_9C80B8DF00BFC452494B36BEFB420DD0" xlink:to="loc_us-gaap_IncomeTaxAuthorityDomain_288BBC3EADF84261E74E36BEFB433937" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InternalRevenueServiceIRSMember" xlink:label="loc_us-gaap_InternalRevenueServiceIRSMember_D5494D8E768AD47729D336BEFB43760F" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeTaxAuthorityDomain_288BBC3EADF84261E74E36BEFB433937" xlink:to="loc_us-gaap_InternalRevenueServiceIRSMember_D5494D8E768AD47729D336BEFB43760F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ForeignCountryMember" xlink:label="loc_us-gaap_ForeignCountryMember_743FCEBC92783237005D36BEFB433043" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeTaxAuthorityDomain_288BBC3EADF84261E74E36BEFB433937" xlink:to="loc_us-gaap_ForeignCountryMember_743FCEBC92783237005D36BEFB433043" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StateAndLocalJurisdictionMember" xlink:label="loc_us-gaap_StateAndLocalJurisdictionMember_891D17852F48B519873436BEFB44B8BE" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeTaxAuthorityDomain_288BBC3EADF84261E74E36BEFB433937" xlink:to="loc_us-gaap_StateAndLocalJurisdictionMember_891D17852F48B519873436BEFB44B8BE" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_TaxCutsAndJobsActOf2017IncompleteAccountingChangeInTaxRateProvisionalIncomeTaxExpenseBenefit" xlink:label="loc_us-gaap_TaxCutsAndJobsActOf2017IncompleteAccountingChangeInTaxRateProvisionalIncomeTaxExpenseBenefit_5AD0234CB21F15C7330D36BF65A7B06B" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingLossCarryforwardsLineItems_128EECF04E90CCACEFE636BEFB443F22" xlink:to="loc_us-gaap_TaxCutsAndJobsActOf2017IncompleteAccountingChangeInTaxRateProvisionalIncomeTaxExpenseBenefit_5AD0234CB21F15C7330D36BF65A7B06B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_TaxCutsAndJobsActOf2017ChangeInTaxRateIncomeTaxExpenseBenefit" xlink:label="loc_us-gaap_TaxCutsAndJobsActOf2017ChangeInTaxRateIncomeTaxExpenseBenefit_2E8B4E96F78810AC066336BF655F1CAF" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingLossCarryforwardsLineItems_128EECF04E90CCACEFE636BEFB443F22" xlink:to="loc_us-gaap_TaxCutsAndJobsActOf2017ChangeInTaxRateIncomeTaxExpenseBenefit_2E8B4E96F78810AC066336BF655F1CAF" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_TaxCutsandJobsActof2017DeferredTaxAssetGlobalIntangibleLowTaxedIncomeProvision" xlink:label="loc_lly_TaxCutsandJobsActof2017DeferredTaxAssetGlobalIntangibleLowTaxedIncomeProvision_74B92486C21AFAFE3A0036C24A675EA4" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingLossCarryforwardsLineItems_128EECF04E90CCACEFE636BEFB443F22" xlink:to="loc_lly_TaxCutsandJobsActof2017DeferredTaxAssetGlobalIntangibleLowTaxedIncomeProvision_74B92486C21AFAFE3A0036C24A675EA4" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_TaxCreditCarryforwardAmount" xlink:label="loc_us-gaap_TaxCreditCarryforwardAmount_7223B3977427E3B3C69436BEFB447B97" xlink:type="locator" />
    <link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingLossCarryforwardsLineItems_128EECF04E90CCACEFE636BEFB443F22" xlink:to="loc_us-gaap_TaxCreditCarryforwardAmount_7223B3977427E3B3C69436BEFB447B97" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OperatingLossCarryforwards" xlink:label="loc_us-gaap_OperatingLossCarryforwards_7866EB67C67678FE1D5036BEFB444365" xlink:type="locator" />
    <link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingLossCarryforwardsLineItems_128EECF04E90CCACEFE636BEFB443F22" xlink:to="loc_us-gaap_OperatingLossCarryforwards_7866EB67C67678FE1D5036BEFB444365" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DeferredTaxAssetsOperatingLossCarryforwardsStateAndLocal" xlink:label="loc_us-gaap_DeferredTaxAssetsOperatingLossCarryforwardsStateAndLocal_4FAB455738D6C6EE9EC836BEFB4458B5" xlink:type="locator" />
    <link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingLossCarryforwardsLineItems_128EECF04E90CCACEFE636BEFB443F22" xlink:to="loc_us-gaap_DeferredTaxAssetsOperatingLossCarryforwardsStateAndLocal_4FAB455738D6C6EE9EC836BEFB4458B5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DeferredTaxAssetsTaxCreditCarryforwardsOther" xlink:label="loc_us-gaap_DeferredTaxAssetsTaxCreditCarryforwardsOther_F4822AA3F84925EE5AA236BEFB450EC0" xlink:type="locator" />
    <link:definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingLossCarryforwardsLineItems_128EECF04E90CCACEFE636BEFB443F22" xlink:to="loc_us-gaap_DeferredTaxAssetsTaxCreditCarryforwardsOther_F4822AA3F84925EE5AA236BEFB450EC0" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_DomesticandPuertoRicanContributiontoIncomebeforeIncomeTaxes" xlink:label="loc_lly_DomesticandPuertoRicanContributiontoIncomebeforeIncomeTaxes_551493FF84F22A54852736BEFB45279B" xlink:type="locator" />
    <link:definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingLossCarryforwardsLineItems_128EECF04E90CCACEFE636BEFB443F22" xlink:to="loc_lly_DomesticandPuertoRicanContributiontoIncomebeforeIncomeTaxes_551493FF84F22A54852736BEFB45279B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_UnrecognizedTaxBenefitsThatWouldImpactEffectiveTaxRate" xlink:label="loc_us-gaap_UnrecognizedTaxBenefitsThatWouldImpactEffectiveTaxRate_804F2B0782D5D437C7CE36BEFB45EE05" xlink:type="locator" />
    <link:definitionArc order="9" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingLossCarryforwardsLineItems_128EECF04E90CCACEFE636BEFB443F22" xlink:to="loc_us-gaap_UnrecognizedTaxBenefitsThatWouldImpactEffectiveTaxRate_804F2B0782D5D437C7CE36BEFB45EE05" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DecreaseInUnrecognizedTaxBenefitsIsReasonablyPossible" xlink:label="loc_us-gaap_DecreaseInUnrecognizedTaxBenefitsIsReasonablyPossible_F709637128B94235F34536BEFB45EA62" xlink:type="locator" />
    <link:definitionArc order="10" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingLossCarryforwardsLineItems_128EECF04E90CCACEFE636BEFB443F22" xlink:to="loc_us-gaap_DecreaseInUnrecognizedTaxBenefitsIsReasonablyPossible_F709637128B94235F34536BEFB45EA62" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_PaymentsForIncomeTaxSettlements" xlink:label="loc_lly_PaymentsForIncomeTaxSettlements_98DDBA898B52CEF4D46836BEFB45B7B4" xlink:type="locator" />
    <link:definitionArc order="11" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingLossCarryforwardsLineItems_128EECF04E90CCACEFE636BEFB443F22" xlink:to="loc_lly_PaymentsForIncomeTaxSettlements_98DDBA898B52CEF4D46836BEFB45B7B4" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_UnrecognizedTaxBenefitsIncomeTaxPenaltiesAndInterestAccrued" xlink:label="loc_us-gaap_UnrecognizedTaxBenefitsIncomeTaxPenaltiesAndInterestAccrued_1EEEE2B4321DED9C166336BEFB4509CC" xlink:type="locator" />
    <link:definitionArc order="12" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingLossCarryforwardsLineItems_128EECF04E90CCACEFE636BEFB443F22" xlink:to="loc_us-gaap_UnrecognizedTaxBenefitsIncomeTaxPenaltiesAndInterestAccrued_1EEEE2B4321DED9C166336BEFB4509CC" xlink:type="arc" />
  </link:definitionLink>
  <link:definitionLink xlink:role="http://www.lilly.com/role/IncomeTaxesPolicies" xlink:type="extended" />
  <link:definitionLink xlink:role="http://www.lilly.com/role/IncomeTaxesScheduleOfCashPaymentsOfIncomeTaxesDetails" xlink:type="extended" />
  <link:definitionLink xlink:role="http://www.lilly.com/role/IncomeTaxesScheduleOfCompositionOfIncomeTaxExpenseDetails" xlink:type="extended" />
  <link:definitionLink xlink:role="http://www.lilly.com/role/IncomeTaxesScheduleOfDeferredTaxAssetAndLiabilitiesDetails" xlink:type="extended" />
  <link:definitionLink xlink:role="http://www.lilly.com/role/IncomeTaxesScheduleOfIncomeTaxBenefitExpenseRelatedToInterestAndPenaltiesDetails" xlink:type="extended" />
  <link:definitionLink xlink:role="http://www.lilly.com/role/IncomeTaxesScheduleOfReconciliationOfIncomeTaxesDetails" xlink:type="extended" />
  <link:definitionLink xlink:role="http://www.lilly.com/role/IncomeTaxesScheduleOfUnrecognizedTaxBenefitsDetails" xlink:type="extended" />
  <link:definitionLink xlink:role="http://www.lilly.com/role/IncomeTaxesTables" xlink:type="extended" />
  <link:definitionLink xlink:role="http://www.lilly.com/role/Inventories" xlink:type="extended" />
  <link:definitionLink xlink:role="http://www.lilly.com/role/InventoriesDetails" xlink:type="extended" />
  <link:definitionLink xlink:role="http://www.lilly.com/role/InventoriesPolicies" xlink:type="extended" />
  <link:definitionLink xlink:role="http://www.lilly.com/role/InventoriesTables" xlink:type="extended" />
  <link:definitionLink xlink:role="http://www.lilly.com/role/Leases" xlink:type="extended" />
  <link:definitionLink xlink:role="http://www.lilly.com/role/LeasesImpactOfLeasesToConsolidatedCondensedFinancialStatementsDetails" xlink:type="extended" />
  <link:definitionLink xlink:role="http://www.lilly.com/role/LeasesMaturitiesOfOperatingLeaseLiabilitiesDetails" xlink:type="extended" />
  <link:definitionLink xlink:role="http://www.lilly.com/role/LeasesNarrativeDetails" xlink:type="extended" />
  <link:definitionLink xlink:role="http://www.lilly.com/role/LeasesTables" xlink:type="extended" />
  <link:definitionLink xlink:role="http://www.lilly.com/role/OtherComprehensiveIncomeLoss" xlink:type="extended" />
  <link:definitionLink xlink:role="http://www.lilly.com/role/OtherComprehensiveIncomeLossScheduleOfComponentOfOtherComprehensiveIncomeLossDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_653F0746A8DFB98EC7B736C0E8FBF42B" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossTable" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_547CED5C30424CA84E9936C0E8F82CAB" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_653F0746A8DFB98EC7B736C0E8FBF42B" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_547CED5C30424CA84E9936C0E8F82CAB" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementOperatingActivitiesSegmentAxis" xlink:label="loc_us-gaap_StatementOperatingActivitiesSegmentAxis_3B47838E511B01F03BEA36C0E8F88E27" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_547CED5C30424CA84E9936C0E8F82CAB" xlink:to="loc_us-gaap_StatementOperatingActivitiesSegmentAxis_3B47838E511B01F03BEA36C0E8F88E27" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SegmentOperatingActivitiesDomain" xlink:label="loc_us-gaap_SegmentOperatingActivitiesDomain_9848027839AAB60C2C3036C0E8F96328_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementOperatingActivitiesSegmentAxis_3B47838E511B01F03BEA36C0E8F88E27" xlink:to="loc_us-gaap_SegmentOperatingActivitiesDomain_9848027839AAB60C2C3036C0E8F96328_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SegmentOperatingActivitiesDomain" xlink:label="loc_us-gaap_SegmentOperatingActivitiesDomain_9848027839AAB60C2C3036C0E8F96328" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementOperatingActivitiesSegmentAxis_3B47838E511B01F03BEA36C0E8F88E27" xlink:to="loc_us-gaap_SegmentOperatingActivitiesDomain_9848027839AAB60C2C3036C0E8F96328" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SegmentContinuingOperationsMember" xlink:label="loc_us-gaap_SegmentContinuingOperationsMember_0408C164C9CC2BE12BE636C0E8F94C36" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentOperatingActivitiesDomain_9848027839AAB60C2C3036C0E8F96328" xlink:to="loc_us-gaap_SegmentContinuingOperationsMember_0408C164C9CC2BE12BE636C0E8F94C36" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SegmentDiscontinuedOperationsMember" xlink:label="loc_us-gaap_SegmentDiscontinuedOperationsMember_BB2572669C932DFC3A4F36C0E8F9506C" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentOperatingActivitiesDomain_9848027839AAB60C2C3036C0E8F96328" xlink:to="loc_us-gaap_SegmentDiscontinuedOperationsMember_BB2572669C932DFC3A4F36C0E8F9506C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementEquityComponentsAxis" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_4A7AFA9B51239C560E9136C0E8F9A832" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_547CED5C30424CA84E9936C0E8F82CAB" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_4A7AFA9B51239C560E9136C0E8F9A832" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EquityComponentDomain" xlink:label="loc_us-gaap_EquityComponentDomain_302D62A84B6F2734CA3A36C0E8F931A5_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_4A7AFA9B51239C560E9136C0E8F9A832" xlink:to="loc_us-gaap_EquityComponentDomain_302D62A84B6F2734CA3A36C0E8F931A5_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EquityComponentDomain" xlink:label="loc_us-gaap_EquityComponentDomain_302D62A84B6F2734CA3A36C0E8F931A5" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_4A7AFA9B51239C560E9136C0E8F9A832" xlink:to="loc_us-gaap_EquityComponentDomain_302D62A84B6F2734CA3A36C0E8F931A5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AociIncludingPortionAttributableToNoncontrollingInterestMember" xlink:label="loc_us-gaap_AociIncludingPortionAttributableToNoncontrollingInterestMember_5CBE8A13D910D52285F436C0E8FAFFAA" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_302D62A84B6F2734CA3A36C0E8F931A5" xlink:to="loc_us-gaap_AociIncludingPortionAttributableToNoncontrollingInterestMember_5CBE8A13D910D52285F436C0E8FAFFAA" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AccumulatedForeignCurrencyAdjustmentIncludingPortionAttributableToNoncontrollingInterestMember" xlink:label="loc_us-gaap_AccumulatedForeignCurrencyAdjustmentIncludingPortionAttributableToNoncontrollingInterestMember_15EE703017BF7760F92636C0E8FAF8D4" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AociIncludingPortionAttributableToNoncontrollingInterestMember_5CBE8A13D910D52285F436C0E8FAFFAA" xlink:to="loc_us-gaap_AccumulatedForeignCurrencyAdjustmentIncludingPortionAttributableToNoncontrollingInterestMember_15EE703017BF7760F92636C0E8FAF8D4" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AccumulatedNetInvestmentGainLossIncludingPortionAttributableToNoncontrollingInterestMember" xlink:label="loc_us-gaap_AccumulatedNetInvestmentGainLossIncludingPortionAttributableToNoncontrollingInterestMember_D2C84DC8CC61A4AAF83F36C0E8FA0FD8" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AociIncludingPortionAttributableToNoncontrollingInterestMember_5CBE8A13D910D52285F436C0E8FAFFAA" xlink:to="loc_us-gaap_AccumulatedNetInvestmentGainLossIncludingPortionAttributableToNoncontrollingInterestMember_D2C84DC8CC61A4AAF83F36C0E8FA0FD8" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AccumulatedDefinedBenefitPlansAdjustmentIncludingPortionAttributableToNoncontrollingInterestMember" xlink:label="loc_us-gaap_AccumulatedDefinedBenefitPlansAdjustmentIncludingPortionAttributableToNoncontrollingInterestMember_1E3CD13851705DA8D9E136C0E8FBEFAE" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AociIncludingPortionAttributableToNoncontrollingInterestMember_5CBE8A13D910D52285F436C0E8FAFFAA" xlink:to="loc_us-gaap_AccumulatedDefinedBenefitPlansAdjustmentIncludingPortionAttributableToNoncontrollingInterestMember_1E3CD13851705DA8D9E136C0E8FBEFAE" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AccumulatedNetGainLossFromCashFlowHedgesIncludingPortionAttributableToNoncontrollingInterestMember" xlink:label="loc_us-gaap_AccumulatedNetGainLossFromCashFlowHedgesIncludingPortionAttributableToNoncontrollingInterestMember_064FE21E1C465EC773DE36C0E8FB2750" xlink:type="locator" />
    <link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AociIncludingPortionAttributableToNoncontrollingInterestMember_5CBE8A13D910D52285F436C0E8FAFFAA" xlink:to="loc_us-gaap_AccumulatedNetGainLossFromCashFlowHedgesIncludingPortionAttributableToNoncontrollingInterestMember_064FE21E1C465EC773DE36C0E8FB2750" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AccumulatedGainLossCashFlowHedgeIncludingNoncontrollingInterestMember" xlink:label="loc_us-gaap_AccumulatedGainLossCashFlowHedgeIncludingNoncontrollingInterestMember_F6AD28B4536C978EB5E036C0E8FB0FDF" xlink:type="locator" />
    <link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AociIncludingPortionAttributableToNoncontrollingInterestMember_5CBE8A13D910D52285F436C0E8FAFFAA" xlink:to="loc_us-gaap_AccumulatedGainLossCashFlowHedgeIncludingNoncontrollingInterestMember_F6AD28B4536C978EB5E036C0E8FB0FDF" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeMember" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_9EB2E9ACCCAB9357DE0836C0E8FBCEC8" xlink:type="locator" />
    <link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AociIncludingPortionAttributableToNoncontrollingInterestMember_5CBE8A13D910D52285F436C0E8FAFFAA" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_9EB2E9ACCCAB9357DE0836C0E8FBCEC8" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AociAttributableToNoncontrollingInterestMember" xlink:label="loc_us-gaap_AociAttributableToNoncontrollingInterestMember_18A246F4894898A6321436C0E8FBCB81" xlink:type="locator" />
    <link:definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AociIncludingPortionAttributableToNoncontrollingInterestMember_5CBE8A13D910D52285F436C0E8FAFFAA" xlink:to="loc_us-gaap_AociAttributableToNoncontrollingInterestMember_18A246F4894898A6321436C0E8FBCB81" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTaxAbstract" xlink:label="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTaxAbstract_698AD4AE4761C17DAF8E36C0E8FC7A84" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_653F0746A8DFB98EC7B736C0E8FBF42B" xlink:to="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTaxAbstract_698AD4AE4761C17DAF8E36C0E8FC7A84" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_A9E2D0669C57F95477B536C0E8FC5C9A" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTaxAbstract_698AD4AE4761C17DAF8E36C0E8FC7A84" xlink:to="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_A9E2D0669C57F95477B536C0E8FC5C9A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CumulativeEffectOfNewAccountingPrincipleInPeriodOfAdoption" xlink:label="loc_us-gaap_CumulativeEffectOfNewAccountingPrincipleInPeriodOfAdoption_5BEEC9CEBDE8C93D95D736C0E8FC96B9" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTaxAbstract_698AD4AE4761C17DAF8E36C0E8FC7A84" xlink:to="loc_us-gaap_CumulativeEffectOfNewAccountingPrincipleInPeriodOfAdoption_5BEEC9CEBDE8C93D95D736C0E8FC96B9" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossBeforeReclassificationsNetOfTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossBeforeReclassificationsNetOfTax_8A2998C84B13A316D57136C0E8FC53FC" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTaxAbstract_698AD4AE4761C17DAF8E36C0E8FC7A84" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossBeforeReclassificationsNetOfTax_8A2998C84B13A316D57136C0E8FC53FC" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTax" xlink:label="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTax_30C2A98CBBB0C15695AA36C0E8FC81E4" xlink:type="locator" />
    <link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTaxAbstract_698AD4AE4761C17DAF8E36C0E8FC7A84" xlink:to="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTax_30C2A98CBBB0C15695AA36C0E8FC81E4" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_93F40B092100D9FE6F1F36C0E8FD06D2" xlink:type="locator" />
    <link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTaxAbstract_698AD4AE4761C17DAF8E36C0E8FC7A84" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_93F40B092100D9FE6F1F36C0E8FD06D2" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_TaxCutsAndJobsActOf2017ReclassificationFromAociToRetainedEarningsTaxEffect" xlink:label="loc_us-gaap_TaxCutsAndJobsActOf2017ReclassificationFromAociToRetainedEarningsTaxEffect_512D601BCF6B2256892D36C0E8FD38AE" xlink:type="locator" />
    <link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTaxAbstract_698AD4AE4761C17DAF8E36C0E8FC7A84" xlink:to="loc_us-gaap_TaxCutsAndJobsActOf2017ReclassificationFromAociToRetainedEarningsTaxEffect_512D601BCF6B2256892D36C0E8FD38AE" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_16DE256483698C2570AD36C0E8FDCF3D" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_653F0746A8DFB98EC7B736C0E8FBF42B" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_16DE256483698C2570AD36C0E8FDCF3D" xlink:type="arc" />
  </link:definitionLink>
  <link:definitionLink xlink:role="http://www.lilly.com/role/OtherComprehensiveIncomeLossScheduleOfReclassificationsOutOfAccumulatedOtherComprehensiveLossDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ReclassificationAdjustmentOutOfAccumulatedOtherComprehensiveIncomeLineItems" xlink:label="loc_us-gaap_ReclassificationAdjustmentOutOfAccumulatedOtherComprehensiveIncomeLineItems_6A1BA627C145A36602C936C0E8EA66A3" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeTable" xlink:label="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeTable_EEA70AA66340FD28693736C0E8E84405" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ReclassificationAdjustmentOutOfAccumulatedOtherComprehensiveIncomeLineItems_6A1BA627C145A36602C936C0E8EA66A3" xlink:to="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeTable_EEA70AA66340FD28693736C0E8E84405" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementEquityComponentsAxis" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_4508D3022CB269C5AC7C36C0E8E85F4E" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeTable_EEA70AA66340FD28693736C0E8E84405" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_4508D3022CB269C5AC7C36C0E8E85F4E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EquityComponentDomain" xlink:label="loc_us-gaap_EquityComponentDomain_79B453932E2A31757B0F36C0E8E8E58B_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_4508D3022CB269C5AC7C36C0E8E85F4E" xlink:to="loc_us-gaap_EquityComponentDomain_79B453932E2A31757B0F36C0E8E8E58B_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EquityComponentDomain" xlink:label="loc_us-gaap_EquityComponentDomain_79B453932E2A31757B0F36C0E8E8E58B" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_4508D3022CB269C5AC7C36C0E8E85F4E" xlink:to="loc_us-gaap_EquityComponentDomain_79B453932E2A31757B0F36C0E8E8E58B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AccumulatedDefinedBenefitPlansAdjustmentIncludingPortionAttributableToNoncontrollingInterestMember" xlink:label="loc_us-gaap_AccumulatedDefinedBenefitPlansAdjustmentIncludingPortionAttributableToNoncontrollingInterestMember_D199B62907D97103BE8D36C0E8E990AB" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_79B453932E2A31757B0F36C0E8E8E58B" xlink:to="loc_us-gaap_AccumulatedDefinedBenefitPlansAdjustmentIncludingPortionAttributableToNoncontrollingInterestMember_D199B62907D97103BE8D36C0E8E990AB" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AccumulatedDefinedBenefitPlansAdjustmentNetPriorServiceIncludingPortionAttributableToNoncontrollingInterestMember" xlink:label="loc_us-gaap_AccumulatedDefinedBenefitPlansAdjustmentNetPriorServiceIncludingPortionAttributableToNoncontrollingInterestMember_F21112007979BAE1791436C0E8E9EE95" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccumulatedDefinedBenefitPlansAdjustmentIncludingPortionAttributableToNoncontrollingInterestMember_D199B62907D97103BE8D36C0E8E990AB" xlink:to="loc_us-gaap_AccumulatedDefinedBenefitPlansAdjustmentNetPriorServiceIncludingPortionAttributableToNoncontrollingInterestMember_F21112007979BAE1791436C0E8E9EE95" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AccumulatedDefinedBenefitPlansAdjustmentNetGainLossIncludingPortionAttributableToNoncontrollingInterestMember" xlink:label="loc_us-gaap_AccumulatedDefinedBenefitPlansAdjustmentNetGainLossIncludingPortionAttributableToNoncontrollingInterestMember_8D8D1E1C069F237FA30636C0E8E94362" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccumulatedDefinedBenefitPlansAdjustmentIncludingPortionAttributableToNoncontrollingInterestMember_D199B62907D97103BE8D36C0E8E990AB" xlink:to="loc_us-gaap_AccumulatedDefinedBenefitPlansAdjustmentNetGainLossIncludingPortionAttributableToNoncontrollingInterestMember_8D8D1E1C069F237FA30636C0E8E94362" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AccumulatedNetInvestmentGainLossIncludingPortionAttributableToNoncontrollingInterestMember" xlink:label="loc_us-gaap_AccumulatedNetInvestmentGainLossIncludingPortionAttributableToNoncontrollingInterestMember_C05104E87E9954FF4B2A36C0E8E90EB8" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_79B453932E2A31757B0F36C0E8E8E58B" xlink:to="loc_us-gaap_AccumulatedNetInvestmentGainLossIncludingPortionAttributableToNoncontrollingInterestMember_C05104E87E9954FF4B2A36C0E8E90EB8" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_AccumulatedNetGainLossfromCashFlowHedgesandForeignCurrencyAdjustmentIncludingPortionAttributabletoNoncontrollingInterestMember" xlink:label="loc_lly_AccumulatedNetGainLossfromCashFlowHedgesandForeignCurrencyAdjustmentIncludingPortionAttributabletoNoncontrollingInterestMember_916E8D8BF4425F47A6AD36C0E8EA5CAD" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_79B453932E2A31757B0F36C0E8E8E58B" xlink:to="loc_lly_AccumulatedNetGainLossfromCashFlowHedgesandForeignCurrencyAdjustmentIncludingPortionAttributabletoNoncontrollingInterestMember_916E8D8BF4425F47A6AD36C0E8EA5CAD" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeAxis" xlink:label="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeAxis_DA16B62AFEF252E0009236C0E8EAE4CD" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeTable_EEA70AA66340FD28693736C0E8E84405" xlink:to="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeAxis_DA16B62AFEF252E0009236C0E8EAE4CD" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeDomain" xlink:label="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeDomain_CCB00B386208F9FFDEC336C0E8EA1C18_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeAxis_DA16B62AFEF252E0009236C0E8EAE4CD" xlink:to="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeDomain_CCB00B386208F9FFDEC336C0E8EA1C18_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeDomain" xlink:label="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeDomain_CCB00B386208F9FFDEC336C0E8EA1C18" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeAxis_DA16B62AFEF252E0009236C0E8EAE4CD" xlink:to="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeDomain_CCB00B386208F9FFDEC336C0E8EA1C18" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeMember" xlink:label="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeMember_F8B582D615F36B7B6D7F36C0E8EAC177" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeDomain_CCB00B386208F9FFDEC336C0E8EA1C18" xlink:to="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeMember_F8B582D615F36B7B6D7F36C0E8EAC177" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherNonoperatingIncomeExpense" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_CEDFCD024534F4710C9A36C0E8EBE8BA" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ReclassificationAdjustmentOutOfAccumulatedOtherComprehensiveIncomeLineItems_6A1BA627C145A36602C936C0E8EA66A3" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpense_CEDFCD024534F4710C9A36C0E8EBE8BA" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_9FDE9D79F1CD4FFA3A2036C0E8EB1AD5" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ReclassificationAdjustmentOutOfAccumulatedOtherComprehensiveIncomeLineItems_6A1BA627C145A36602C936C0E8EA66A3" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_9FDE9D79F1CD4FFA3A2036C0E8EB1AD5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeTaxExpenseBenefit" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_61993B8C63300294F63136C0E8EB17CB" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ReclassificationAdjustmentOutOfAccumulatedOtherComprehensiveIncomeLineItems_6A1BA627C145A36602C936C0E8EA66A3" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_61993B8C63300294F63136C0E8EB17CB" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest_4777F594F0DE2A0A0DD436C0E8EBB9A9" xlink:type="locator" />
    <link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ReclassificationAdjustmentOutOfAccumulatedOtherComprehensiveIncomeLineItems_6A1BA627C145A36602C936C0E8EA66A3" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest_4777F594F0DE2A0A0DD436C0E8EBB9A9" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTax" xlink:label="loc_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTax_10F5014CCF25A3EB232436C0E8EBC7BD" xlink:type="locator" />
    <link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ReclassificationAdjustmentOutOfAccumulatedOtherComprehensiveIncomeLineItems_6A1BA627C145A36602C936C0E8EA66A3" xlink:to="loc_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTax_10F5014CCF25A3EB232436C0E8EBC7BD" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ProfitLoss" xlink:label="loc_us-gaap_ProfitLoss_83E39966A3FECF121A8036C0E8EC4F67" xlink:type="locator" />
    <link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ReclassificationAdjustmentOutOfAccumulatedOtherComprehensiveIncomeLineItems_6A1BA627C145A36602C936C0E8EA66A3" xlink:to="loc_us-gaap_ProfitLoss_83E39966A3FECF121A8036C0E8EC4F67" xlink:type="arc" />
  </link:definitionLink>
  <link:definitionLink xlink:role="http://www.lilly.com/role/OtherComprehensiveIncomeLossScheduleOfTaxEffectsDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_C2C743D562CC6771C0CF36C0E8F2377C" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossTable" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_10B4668D6340701B848D36C0E8F0F64E" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_C2C743D562CC6771C0CF36C0E8F2377C" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_10B4668D6340701B848D36C0E8F0F64E" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementEquityComponentsAxis" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_4B8B3F575357D2FD45E236C0E8F03ACA" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_10B4668D6340701B848D36C0E8F0F64E" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_4B8B3F575357D2FD45E236C0E8F03ACA" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EquityComponentDomain" xlink:label="loc_us-gaap_EquityComponentDomain_BFF21984C830DCE1325D36C0E8F16732_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_4B8B3F575357D2FD45E236C0E8F03ACA" xlink:to="loc_us-gaap_EquityComponentDomain_BFF21984C830DCE1325D36C0E8F16732_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EquityComponentDomain" xlink:label="loc_us-gaap_EquityComponentDomain_BFF21984C830DCE1325D36C0E8F16732" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_4B8B3F575357D2FD45E236C0E8F03ACA" xlink:to="loc_us-gaap_EquityComponentDomain_BFF21984C830DCE1325D36C0E8F16732" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AccumulatedForeignCurrencyAdjustmentIncludingPortionAttributableToNoncontrollingInterestMember" xlink:label="loc_us-gaap_AccumulatedForeignCurrencyAdjustmentIncludingPortionAttributableToNoncontrollingInterestMember_125C544D61030ED1FB3436C0E8F1EFE9" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_BFF21984C830DCE1325D36C0E8F16732" xlink:to="loc_us-gaap_AccumulatedForeignCurrencyAdjustmentIncludingPortionAttributableToNoncontrollingInterestMember_125C544D61030ED1FB3436C0E8F1EFE9" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AccumulatedNetInvestmentGainLossIncludingPortionAttributableToNoncontrollingInterestMember" xlink:label="loc_us-gaap_AccumulatedNetInvestmentGainLossIncludingPortionAttributableToNoncontrollingInterestMember_EEB066EC4394E6E1578736C0E8F1230F" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_BFF21984C830DCE1325D36C0E8F16732" xlink:to="loc_us-gaap_AccumulatedNetInvestmentGainLossIncludingPortionAttributableToNoncontrollingInterestMember_EEB066EC4394E6E1578736C0E8F1230F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AccumulatedDefinedBenefitPlansAdjustmentIncludingPortionAttributableToNoncontrollingInterestMember" xlink:label="loc_us-gaap_AccumulatedDefinedBenefitPlansAdjustmentIncludingPortionAttributableToNoncontrollingInterestMember_E27DDD2A3014D3F67FE136C0E8F123A3" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_BFF21984C830DCE1325D36C0E8F16732" xlink:to="loc_us-gaap_AccumulatedDefinedBenefitPlansAdjustmentIncludingPortionAttributableToNoncontrollingInterestMember_E27DDD2A3014D3F67FE136C0E8F123A3" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AccumulatedNetGainLossFromCashFlowHedgesIncludingPortionAttributableToNoncontrollingInterestMember" xlink:label="loc_us-gaap_AccumulatedNetGainLossFromCashFlowHedgesIncludingPortionAttributableToNoncontrollingInterestMember_306FF8CEF8F984442D5736C0E8F10A99" xlink:type="locator" />
    <link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_BFF21984C830DCE1325D36C0E8F16732" xlink:to="loc_us-gaap_AccumulatedNetGainLossFromCashFlowHedgesIncludingPortionAttributableToNoncontrollingInterestMember_306FF8CEF8F984442D5736C0E8F10A99" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossTax_0880D9877DA50017038A36C0E8F29797" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_C2C743D562CC6771C0CF36C0E8F2377C" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossTax_0880D9877DA50017038A36C0E8F29797" xlink:type="arc" />
  </link:definitionLink>
  <link:definitionLink xlink:role="http://www.lilly.com/role/OtherComprehensiveIncomeLossTables" xlink:type="extended" />
  <link:definitionLink xlink:role="http://www.lilly.com/role/OtherNetIncomeExpense" xlink:type="extended" />
  <link:definitionLink xlink:role="http://www.lilly.com/role/OtherNetIncomeExpenseDetails" xlink:type="extended" />
  <link:definitionLink xlink:role="http://www.lilly.com/role/OtherNetIncomeExpenseTables" xlink:type="extended" />
  <link:definitionLink xlink:role="http://www.lilly.com/role/PropertyAndEquipment" xlink:type="extended" />
  <link:definitionLink xlink:role="http://www.lilly.com/role/PropertyAndEquipmentNarrativeDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PropertyPlantAndEquipmentLineItems" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentLineItems_692312F7D26F3BDA9A63AE7CD70A4FDE" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfPropertyPlantAndEquipmentTable" xlink:label="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_27351E90EA319A861AFAAE7CD7071D75" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_692312F7D26F3BDA9A63AE7CD70A4FDE" xlink:to="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_27351E90EA319A861AFAAE7CD7071D75" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PropertyPlantAndEquipmentByTypeAxis" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_3DF478C8F2A6C67F71C5AE7CD707B516" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_27351E90EA319A861AFAAE7CD7071D75" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_3DF478C8F2A6C67F71C5AE7CD707B516" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_9D250508B148197C975AAE7CD708A035_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_3DF478C8F2A6C67F71C5AE7CD707B516" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_9D250508B148197C975AAE7CD708A035_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_9D250508B148197C975AAE7CD708A035" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_3DF478C8F2A6C67F71C5AE7CD707B516" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_9D250508B148197C975AAE7CD708A035" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_BuildingMember" xlink:label="loc_us-gaap_BuildingMember_45EC68599014954BC054AE7CD723CA62" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_9D250508B148197C975AAE7CD708A035" xlink:to="loc_us-gaap_BuildingMember_45EC68599014954BC054AE7CD723CA62" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EquipmentMember" xlink:label="loc_us-gaap_EquipmentMember_60DCB75A45162EABCE1EAE7CD7442FF2" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_9D250508B148197C975AAE7CD708A035" xlink:to="loc_us-gaap_EquipmentMember_60DCB75A45162EABCE1EAE7CD7442FF2" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_RangeAxis" xlink:label="loc_srt_RangeAxis_18439FBB5ED19F13BE56AE7CD709445A" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_27351E90EA319A861AFAAE7CD7071D75" xlink:to="loc_srt_RangeAxis_18439FBB5ED19F13BE56AE7CD709445A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_RangeMember" xlink:label="loc_srt_RangeMember_F89E4A96F074C3504EE3AE7CD70949E3_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_18439FBB5ED19F13BE56AE7CD709445A" xlink:to="loc_srt_RangeMember_F89E4A96F074C3504EE3AE7CD70949E3_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_RangeMember" xlink:label="loc_srt_RangeMember_F89E4A96F074C3504EE3AE7CD70949E3" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_18439FBB5ED19F13BE56AE7CD709445A" xlink:to="loc_srt_RangeMember_F89E4A96F074C3504EE3AE7CD70949E3" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_MinimumMember" xlink:label="loc_srt_MinimumMember_0C81D526CA8BE669B32AAE7CD72D2489" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_F89E4A96F074C3504EE3AE7CD70949E3" xlink:to="loc_srt_MinimumMember_0C81D526CA8BE669B32AAE7CD72D2489" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_MaximumMember" xlink:label="loc_srt_MaximumMember_EB10F05F7BA60529B7BBAE7CD739F271" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_F89E4A96F074C3504EE3AE7CD70949E3" xlink:to="loc_srt_MaximumMember_EB10F05F7BA60529B7BBAE7CD739F271" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PropertyPlantAndEquipmentUsefulLife" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentUsefulLife_B5A22ACAA28F862BB55CAE7CD7161A92" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_692312F7D26F3BDA9A63AE7CD70A4FDE" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentUsefulLife_B5A22ACAA28F862BB55CAE7CD7161A92" xlink:type="arc" />
  </link:definitionLink>
  <link:definitionLink xlink:role="http://www.lilly.com/role/PropertyAndEquipmentPolicies" xlink:type="extended" />
  <link:definitionLink xlink:role="http://www.lilly.com/role/PropertyAndEquipmentScheduleOfDepreciationExpenseDetails" xlink:type="extended" />
  <link:definitionLink xlink:role="http://www.lilly.com/role/PropertyAndEquipmentScheduleOfGeographicInformationDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PropertyPlantAndEquipmentLineItems" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentLineItems_8FBB10290D1B384D3E893AC8AC62A854" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfPropertyPlantAndEquipmentTable" xlink:label="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_3913C93AB9F932C2A5EF3AC8AC5F1DD8" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_8FBB10290D1B384D3E893AC8AC62A854" xlink:to="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_3913C93AB9F932C2A5EF3AC8AC5F1DD8" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_StatementGeographicalAxis" xlink:label="loc_srt_StatementGeographicalAxis_BCB94601863C187837853AC8AC5F19C3" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_3913C93AB9F932C2A5EF3AC8AC5F1DD8" xlink:to="loc_srt_StatementGeographicalAxis_BCB94601863C187837853AC8AC5F19C3" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_SegmentGeographicalDomain" xlink:label="loc_srt_SegmentGeographicalDomain_8F0FD371BA8DC19892BD3AC8AC609EEA_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_StatementGeographicalAxis_BCB94601863C187837853AC8AC5F19C3" xlink:to="loc_srt_SegmentGeographicalDomain_8F0FD371BA8DC19892BD3AC8AC609EEA_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_SegmentGeographicalDomain" xlink:label="loc_srt_SegmentGeographicalDomain_8F0FD371BA8DC19892BD3AC8AC609EEA" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_StatementGeographicalAxis_BCB94601863C187837853AC8AC5F19C3" xlink:to="loc_srt_SegmentGeographicalDomain_8F0FD371BA8DC19892BD3AC8AC609EEA" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_UNITEDSTATESAndPUERTORICOMember" xlink:label="loc_lly_UNITEDSTATESAndPUERTORICOMember_69D2395585F6901F34F53AC98BC532C3" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_8F0FD371BA8DC19892BD3AC8AC609EEA" xlink:to="loc_lly_UNITEDSTATESAndPUERTORICOMember_69D2395585F6901F34F53AC98BC532C3" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/country/2017/country-2017-01-31.xsd#country_IE" xlink:label="loc_country_IE_811729D5C8BE328764413AC8AC60E65C" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_8F0FD371BA8DC19892BD3AC8AC609EEA" xlink:to="loc_country_IE_811729D5C8BE328764413AC8AC60E65C" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_OtherForeignCountriesMember" xlink:label="loc_lly_OtherForeignCountriesMember_859CA8E9E2837FD567963AC8AC629F2A" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_8F0FD371BA8DC19892BD3AC8AC609EEA" xlink:to="loc_lly_OtherForeignCountriesMember_859CA8E9E2837FD567963AC8AC629F2A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NoncurrentAssets" xlink:label="loc_us-gaap_NoncurrentAssets_F521CE98C9621CB09F263AC8AC639E66" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_8FBB10290D1B384D3E893AC8AC62A854" xlink:to="loc_us-gaap_NoncurrentAssets_F521CE98C9621CB09F263AC8AC639E66" xlink:type="arc" />
  </link:definitionLink>
  <link:definitionLink xlink:role="http://www.lilly.com/role/PropertyAndEquipmentScheduleOfPropertyAndEquipmentDetails" xlink:type="extended" />
  <link:definitionLink xlink:role="http://www.lilly.com/role/PropertyAndEquipmentTables" xlink:type="extended" />
  <link:definitionLink xlink:role="http://www.lilly.com/role/RetirementBenefits" xlink:type="extended" />
  <link:definitionLink xlink:role="http://www.lilly.com/role/RetirementBenefitsNarrativeDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DefinedBenefitPlanDisclosureLineItems" xlink:label="loc_us-gaap_DefinedBenefitPlanDisclosureLineItems_96D0DB90B902A10B3125ED93D908D479" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfDefinedBenefitPlansDisclosuresTable" xlink:label="loc_us-gaap_ScheduleOfDefinedBenefitPlansDisclosuresTable_04AB31DE018EE28D21DBED93D904BC15" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DefinedBenefitPlanDisclosureLineItems_96D0DB90B902A10B3125ED93D908D479" xlink:to="loc_us-gaap_ScheduleOfDefinedBenefitPlansDisclosuresTable_04AB31DE018EE28D21DBED93D904BC15" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RestructuringPlanAxis" xlink:label="loc_us-gaap_RestructuringPlanAxis_128D4D669408E74CBF03ED93D9051830" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfDefinedBenefitPlansDisclosuresTable_04AB31DE018EE28D21DBED93D904BC15" xlink:to="loc_us-gaap_RestructuringPlanAxis_128D4D669408E74CBF03ED93D9051830" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RestructuringPlanDomain" xlink:label="loc_us-gaap_RestructuringPlanDomain_7252B71A537624F4E0F6ED93D905E8B2_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RestructuringPlanAxis_128D4D669408E74CBF03ED93D9051830" xlink:to="loc_us-gaap_RestructuringPlanDomain_7252B71A537624F4E0F6ED93D905E8B2_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RestructuringPlanDomain" xlink:label="loc_us-gaap_RestructuringPlanDomain_7252B71A537624F4E0F6ED93D905E8B2" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RestructuringPlanAxis_128D4D669408E74CBF03ED93D9051830" xlink:to="loc_us-gaap_RestructuringPlanDomain_7252B71A537624F4E0F6ED93D905E8B2" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_A2017WorkforceReductionPlanMember" xlink:label="loc_lly_A2017WorkforceReductionPlanMember_42A7E21862BA4C386157ED93D905CC9B" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringPlanDomain_7252B71A537624F4E0F6ED93D905E8B2" xlink:to="loc_lly_A2017WorkforceReductionPlanMember_42A7E21862BA4C386157ED93D905CC9B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RestructuringCostAndReserveAxis" xlink:label="loc_us-gaap_RestructuringCostAndReserveAxis_490C61A157E942C40933ED93D905A1C7" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfDefinedBenefitPlansDisclosuresTable_04AB31DE018EE28D21DBED93D904BC15" xlink:to="loc_us-gaap_RestructuringCostAndReserveAxis_490C61A157E942C40933ED93D905A1C7" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_TypeOfRestructuringDomain" xlink:label="loc_us-gaap_TypeOfRestructuringDomain_5431622E1C2699865FA0ED93D9060D29_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RestructuringCostAndReserveAxis_490C61A157E942C40933ED93D905A1C7" xlink:to="loc_us-gaap_TypeOfRestructuringDomain_5431622E1C2699865FA0ED93D9060D29_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_TypeOfRestructuringDomain" xlink:label="loc_us-gaap_TypeOfRestructuringDomain_5431622E1C2699865FA0ED93D9060D29" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RestructuringCostAndReserveAxis_490C61A157E942C40933ED93D905A1C7" xlink:to="loc_us-gaap_TypeOfRestructuringDomain_5431622E1C2699865FA0ED93D9060D29" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ContractTerminationMember" xlink:label="loc_us-gaap_ContractTerminationMember_384BD552656EBA6CED67ED93D9063157" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TypeOfRestructuringDomain_5431622E1C2699865FA0ED93D9060D29" xlink:to="loc_us-gaap_ContractTerminationMember_384BD552656EBA6CED67ED93D9063157" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StatementOperatingActivitiesSegmentAxis" xlink:label="loc_us-gaap_StatementOperatingActivitiesSegmentAxis_FE7B43E3816CD778B85DED93D906706C" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfDefinedBenefitPlansDisclosuresTable_04AB31DE018EE28D21DBED93D904BC15" xlink:to="loc_us-gaap_StatementOperatingActivitiesSegmentAxis_FE7B43E3816CD778B85DED93D906706C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SegmentOperatingActivitiesDomain" xlink:label="loc_us-gaap_SegmentOperatingActivitiesDomain_A6631542C7E5A616CCB0ED93D906E9B6_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementOperatingActivitiesSegmentAxis_FE7B43E3816CD778B85DED93D906706C" xlink:to="loc_us-gaap_SegmentOperatingActivitiesDomain_A6631542C7E5A616CCB0ED93D906E9B6_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SegmentOperatingActivitiesDomain" xlink:label="loc_us-gaap_SegmentOperatingActivitiesDomain_A6631542C7E5A616CCB0ED93D906E9B6" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementOperatingActivitiesSegmentAxis_FE7B43E3816CD778B85DED93D906706C" xlink:to="loc_us-gaap_SegmentOperatingActivitiesDomain_A6631542C7E5A616CCB0ED93D906E9B6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SegmentDiscontinuedOperationsMember" xlink:label="loc_us-gaap_SegmentDiscontinuedOperationsMember_224630AE45E090719A17ED93D907EC83" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentOperatingActivitiesDomain_A6631542C7E5A616CCB0ED93D906E9B6" xlink:to="loc_us-gaap_SegmentDiscontinuedOperationsMember_224630AE45E090719A17ED93D907EC83" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DefinedBenefitPlanByPlanAssetCategoriesAxis" xlink:label="loc_us-gaap_DefinedBenefitPlanByPlanAssetCategoriesAxis_5058E8367AB25D7E0E4BED93D90752FF" xlink:type="locator" />
    <link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfDefinedBenefitPlansDisclosuresTable_04AB31DE018EE28D21DBED93D904BC15" xlink:to="loc_us-gaap_DefinedBenefitPlanByPlanAssetCategoriesAxis_5058E8367AB25D7E0E4BED93D90752FF" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PlanAssetCategoriesDomain" xlink:label="loc_us-gaap_PlanAssetCategoriesDomain_78BD729B97BBBF815C45ED93D9071257_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DefinedBenefitPlanByPlanAssetCategoriesAxis_5058E8367AB25D7E0E4BED93D90752FF" xlink:to="loc_us-gaap_PlanAssetCategoriesDomain_78BD729B97BBBF815C45ED93D9071257_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PlanAssetCategoriesDomain" xlink:label="loc_us-gaap_PlanAssetCategoriesDomain_78BD729B97BBBF815C45ED93D9071257" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DefinedBenefitPlanByPlanAssetCategoriesAxis_5058E8367AB25D7E0E4BED93D90752FF" xlink:to="loc_us-gaap_PlanAssetCategoriesDomain_78BD729B97BBBF815C45ED93D9071257" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DefinedBenefitPlanEquitySecuritiesMember" xlink:label="loc_us-gaap_DefinedBenefitPlanEquitySecuritiesMember_CD271279E024007B881DED93D9070294" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PlanAssetCategoriesDomain_78BD729B97BBBF815C45ED93D9071257" xlink:to="loc_us-gaap_DefinedBenefitPlanEquitySecuritiesMember_CD271279E024007B881DED93D9070294" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FixedIncomeFundsMember" xlink:label="loc_us-gaap_FixedIncomeFundsMember_6450D8ECE639F4A9383EED93D9085FC9" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PlanAssetCategoriesDomain_78BD729B97BBBF815C45ED93D9071257" xlink:to="loc_us-gaap_FixedIncomeFundsMember_6450D8ECE639F4A9383EED93D9085FC9" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DefinedBenefitPlanBenefitObligationPeriodIncreaseDecrease" xlink:label="loc_us-gaap_DefinedBenefitPlanBenefitObligationPeriodIncreaseDecrease_C163DC626D5B06F832CBED93D908AB99" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanDisclosureLineItems_96D0DB90B902A10B3125ED93D908D479" xlink:to="loc_us-gaap_DefinedBenefitPlanBenefitObligationPeriodIncreaseDecrease_C163DC626D5B06F832CBED93D908AB99" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DefinedBenefitPlanRecognizedNetGainLossDueToCurtailments" xlink:label="loc_us-gaap_DefinedBenefitPlanRecognizedNetGainLossDueToCurtailments_6111ECA9473AABCA9E9EED93D908E633" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanDisclosureLineItems_96D0DB90B902A10B3125ED93D908D479" xlink:to="loc_us-gaap_DefinedBenefitPlanRecognizedNetGainLossDueToCurtailments_6111ECA9473AABCA9E9EED93D908E633" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DefinedBenefitPlanCurtailments" xlink:label="loc_us-gaap_DefinedBenefitPlanCurtailments_82C2FBEEA8E3271093A1ED93D908E23B" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanDisclosureLineItems_96D0DB90B902A10B3125ED93D908D479" xlink:to="loc_us-gaap_DefinedBenefitPlanCurtailments_82C2FBEEA8E3271093A1ED93D908E23B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DefinedBenefitPlanSpecialTerminationBenefits" xlink:label="loc_us-gaap_DefinedBenefitPlanSpecialTerminationBenefits_20DA3C69D89802E30C99ED93D909EF8C" xlink:type="locator" />
    <link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanDisclosureLineItems_96D0DB90B902A10B3125ED93D908D479" xlink:to="loc_us-gaap_DefinedBenefitPlanSpecialTerminationBenefits_20DA3C69D89802E30C99ED93D909EF8C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RestructuringSettlementAndImpairmentProvisions" xlink:label="loc_us-gaap_RestructuringSettlementAndImpairmentProvisions_D66B8503838EEDFB578EED93D909191E" xlink:type="locator" />
    <link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanDisclosureLineItems_96D0DB90B902A10B3125ED93D908D479" xlink:to="loc_us-gaap_RestructuringSettlementAndImpairmentProvisions_D66B8503838EEDFB578EED93D909191E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DefinedContributionPlanCostRecognized" xlink:label="loc_us-gaap_DefinedContributionPlanCostRecognized_B3E8E7D4129DC69D0221ED93D9097FC1" xlink:type="locator" />
    <link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanDisclosureLineItems_96D0DB90B902A10B3125ED93D908D479" xlink:to="loc_us-gaap_DefinedContributionPlanCostRecognized_B3E8E7D4129DC69D0221ED93D9097FC1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DefinedBenefitPlanAccumulatedBenefitObligation" xlink:label="loc_us-gaap_DefinedBenefitPlanAccumulatedBenefitObligation_A4A4CB8FAB84298B9A65ED93D909A475" xlink:type="locator" />
    <link:definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanDisclosureLineItems_96D0DB90B902A10B3125ED93D908D479" xlink:to="loc_us-gaap_DefinedBenefitPlanAccumulatedBenefitObligation_A4A4CB8FAB84298B9A65ED93D909A475" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_DefinedBenefitPlanPercentageOfGlobalInvestmentsInPlanAssets" xlink:label="loc_lly_DefinedBenefitPlanPercentageOfGlobalInvestmentsInPlanAssets_E1F100C2FEC0C5A60B02ED93D90955F2" xlink:type="locator" />
    <link:definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanDisclosureLineItems_96D0DB90B902A10B3125ED93D908D479" xlink:to="loc_lly_DefinedBenefitPlanPercentageOfGlobalInvestmentsInPlanAssets_E1F100C2FEC0C5A60B02ED93D90955F2" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DefinedBenefitPlanPlanAssetsTargetAllocationPercentage" xlink:label="loc_us-gaap_DefinedBenefitPlanPlanAssetsTargetAllocationPercentage_4032D1689E085B29980AED93D90A8D89" xlink:type="locator" />
    <link:definitionArc order="9" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanDisclosureLineItems_96D0DB90B902A10B3125ED93D908D479" xlink:to="loc_us-gaap_DefinedBenefitPlanPlanAssetsTargetAllocationPercentage_4032D1689E085B29980AED93D90A8D89" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_DefinedBenefitPlanEstimatedFutureEmployerContributionsinNextFiscalYearMinimum" xlink:label="loc_lly_DefinedBenefitPlanEstimatedFutureEmployerContributionsinNextFiscalYearMinimum_A80EE1BE117EE8BCCDF1ED93D90A25C5" xlink:type="locator" />
    <link:definitionArc order="10" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanDisclosureLineItems_96D0DB90B902A10B3125ED93D908D479" xlink:to="loc_lly_DefinedBenefitPlanEstimatedFutureEmployerContributionsinNextFiscalYearMinimum_A80EE1BE117EE8BCCDF1ED93D90A25C5" xlink:type="arc" />
  </link:definitionLink>
  <link:definitionLink xlink:role="http://www.lilly.com/role/RetirementBenefitsScheduleOfBenefitObligationsAndPlanAssetsAndFundedStatusDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansTableTextBlockLineItems" xlink:label="loc_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansTableTextBlockLineItems_8FEFCE39273326DE20E65E4E0416DDD9" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansDisclosuresTable" xlink:label="loc_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansDisclosuresTable_E315A889B62752C4C4DE5E4E04159AA7" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansTableTextBlockLineItems_8FEFCE39273326DE20E65E4E0416DDD9" xlink:to="loc_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansDisclosuresTable_E315A889B62752C4C4DE5E4E04159AA7" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RetirementPlanTypeAxis" xlink:label="loc_us-gaap_RetirementPlanTypeAxis_610CC8C6B90A96D7916B5E4E041559FA" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansDisclosuresTable_E315A889B62752C4C4DE5E4E04159AA7" xlink:to="loc_us-gaap_RetirementPlanTypeAxis_610CC8C6B90A96D7916B5E4E041559FA" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RetirementPlanTypeDomain" xlink:label="loc_us-gaap_RetirementPlanTypeDomain_9D814A9767827D81892B5E4E04155FE6_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RetirementPlanTypeAxis_610CC8C6B90A96D7916B5E4E041559FA" xlink:to="loc_us-gaap_RetirementPlanTypeDomain_9D814A9767827D81892B5E4E04155FE6_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RetirementPlanTypeDomain" xlink:label="loc_us-gaap_RetirementPlanTypeDomain_9D814A9767827D81892B5E4E04155FE6" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RetirementPlanTypeAxis_610CC8C6B90A96D7916B5E4E041559FA" xlink:to="loc_us-gaap_RetirementPlanTypeDomain_9D814A9767827D81892B5E4E04155FE6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PensionPlansDefinedBenefitMember" xlink:label="loc_us-gaap_PensionPlansDefinedBenefitMember_64C89DE7F054D72914925E4E0416F49F" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RetirementPlanTypeDomain_9D814A9767827D81892B5E4E04155FE6" xlink:to="loc_us-gaap_PensionPlansDefinedBenefitMember_64C89DE7F054D72914925E4E0416F49F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DefinedBenefitPostretirementHealthCoverageMember" xlink:label="loc_us-gaap_DefinedBenefitPostretirementHealthCoverageMember_3471BAACEADDF612D1775E4E04169818" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RetirementPlanTypeDomain_9D814A9767827D81892B5E4E04155FE6" xlink:to="loc_us-gaap_DefinedBenefitPostretirementHealthCoverageMember_3471BAACEADDF612D1775E4E04169818" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DefinedBenefitPlanChangeInBenefitObligationRollForward" xlink:label="loc_us-gaap_DefinedBenefitPlanChangeInBenefitObligationRollForward_2B360F152BA8690886565E4E041618D5" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansTableTextBlockLineItems_8FEFCE39273326DE20E65E4E0416DDD9" xlink:to="loc_us-gaap_DefinedBenefitPlanChangeInBenefitObligationRollForward_2B360F152BA8690886565E4E041618D5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DefinedBenefitPlanBenefitObligation" xlink:label="loc_us-gaap_DefinedBenefitPlanBenefitObligation_AC1D815DCA64BD7851425E4E0416145B" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanChangeInBenefitObligationRollForward_2B360F152BA8690886565E4E041618D5" xlink:to="loc_us-gaap_DefinedBenefitPlanBenefitObligation_AC1D815DCA64BD7851425E4E0416145B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DefinedBenefitPlanServiceCost" xlink:label="loc_us-gaap_DefinedBenefitPlanServiceCost_2EC67E14B68C00B75E2D5E4E0417E68A" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanChangeInBenefitObligationRollForward_2B360F152BA8690886565E4E041618D5" xlink:to="loc_us-gaap_DefinedBenefitPlanServiceCost_2EC67E14B68C00B75E2D5E4E0417E68A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DefinedBenefitPlanInterestCost" xlink:label="loc_us-gaap_DefinedBenefitPlanInterestCost_AC78F610270F29126B615E4E0417A2DA" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanChangeInBenefitObligationRollForward_2B360F152BA8690886565E4E041618D5" xlink:to="loc_us-gaap_DefinedBenefitPlanInterestCost_AC78F610270F29126B615E4E0417A2DA" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DefinedBenefitPlanActuarialGainLoss" xlink:label="loc_us-gaap_DefinedBenefitPlanActuarialGainLoss_B2713F0E18FFBB5058DF5E4E0417529B" xlink:type="locator" />
    <link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanChangeInBenefitObligationRollForward_2B360F152BA8690886565E4E041618D5" xlink:to="loc_us-gaap_DefinedBenefitPlanActuarialGainLoss_B2713F0E18FFBB5058DF5E4E0417529B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DefinedBenefitPlanBenefitObligationBenefitsPaid" xlink:label="loc_us-gaap_DefinedBenefitPlanBenefitObligationBenefitsPaid_E00F8712683BC52E77465E4E04176004" xlink:type="locator" />
    <link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanChangeInBenefitObligationRollForward_2B360F152BA8690886565E4E041618D5" xlink:to="loc_us-gaap_DefinedBenefitPlanBenefitObligationBenefitsPaid_E00F8712683BC52E77465E4E04176004" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DefinedBenefitPlanPlanAmendments" xlink:label="loc_us-gaap_DefinedBenefitPlanPlanAmendments_2475B9A09FFA9EB6B3505E4E041726F9" xlink:type="locator" />
    <link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanChangeInBenefitObligationRollForward_2B360F152BA8690886565E4E041618D5" xlink:to="loc_us-gaap_DefinedBenefitPlanPlanAmendments_2475B9A09FFA9EB6B3505E4E041726F9" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DefinedBenefitPlanCurtailments" xlink:label="loc_us-gaap_DefinedBenefitPlanCurtailments_1129C047CEAFA71482BE5E4E0418D0B9" xlink:type="locator" />
    <link:definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanChangeInBenefitObligationRollForward_2B360F152BA8690886565E4E041618D5" xlink:to="loc_us-gaap_DefinedBenefitPlanCurtailments_1129C047CEAFA71482BE5E4E0418D0B9" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DefinedBenefitPlanForeignCurrencyExchangeRateChangesBenefitObligation" xlink:label="loc_us-gaap_DefinedBenefitPlanForeignCurrencyExchangeRateChangesBenefitObligation_3D7E54DAF9814402BAB75E4E0418F450" xlink:type="locator" />
    <link:definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanChangeInBenefitObligationRollForward_2B360F152BA8690886565E4E041618D5" xlink:to="loc_us-gaap_DefinedBenefitPlanForeignCurrencyExchangeRateChangesBenefitObligation_3D7E54DAF9814402BAB75E4E0418F450" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DefinedBenefitPlanChangeInFairValueOfPlanAssetsRollForward" xlink:label="loc_us-gaap_DefinedBenefitPlanChangeInFairValueOfPlanAssetsRollForward_8410A3C6B44650BE53785E4E0418B645" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansTableTextBlockLineItems_8FEFCE39273326DE20E65E4E0416DDD9" xlink:to="loc_us-gaap_DefinedBenefitPlanChangeInFairValueOfPlanAssetsRollForward_8410A3C6B44650BE53785E4E0418B645" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DefinedBenefitPlanFairValueOfPlanAssets" xlink:label="loc_us-gaap_DefinedBenefitPlanFairValueOfPlanAssets_C418479B3D747EAA302C5E4E0418E6CD" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanChangeInFairValueOfPlanAssetsRollForward_8410A3C6B44650BE53785E4E0418B645" xlink:to="loc_us-gaap_DefinedBenefitPlanFairValueOfPlanAssets_C418479B3D747EAA302C5E4E0418E6CD" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DefinedBenefitPlanActualReturnOnPlanAssets" xlink:label="loc_us-gaap_DefinedBenefitPlanActualReturnOnPlanAssets_197B3347E3A282C678DA5E4E04189CE3" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanChangeInFairValueOfPlanAssetsRollForward_8410A3C6B44650BE53785E4E0418B645" xlink:to="loc_us-gaap_DefinedBenefitPlanActualReturnOnPlanAssets_197B3347E3A282C678DA5E4E04189CE3" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DefinedBenefitPlanContributionsByEmployer" xlink:label="loc_us-gaap_DefinedBenefitPlanContributionsByEmployer_712B1CA1BBD4C2F2E6B55E4E0419F22D" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanChangeInFairValueOfPlanAssetsRollForward_8410A3C6B44650BE53785E4E0418B645" xlink:to="loc_us-gaap_DefinedBenefitPlanContributionsByEmployer_712B1CA1BBD4C2F2E6B55E4E0419F22D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DefinedBenefitPlanPlanAssetsBenefitsPaid" xlink:label="loc_us-gaap_DefinedBenefitPlanPlanAssetsBenefitsPaid_74C9B701603AE4A483A55E4E0419E655" xlink:type="locator" />
    <link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanChangeInFairValueOfPlanAssetsRollForward_8410A3C6B44650BE53785E4E0418B645" xlink:to="loc_us-gaap_DefinedBenefitPlanPlanAssetsBenefitsPaid_74C9B701603AE4A483A55E4E0419E655" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DefinedBenefitPlanPlanAssetsForeignCurrencyTranslationGainLoss" xlink:label="loc_us-gaap_DefinedBenefitPlanPlanAssetsForeignCurrencyTranslationGainLoss_A6CD22F6A365CD0C77DD5E4E0419431F" xlink:type="locator" />
    <link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanChangeInFairValueOfPlanAssetsRollForward_8410A3C6B44650BE53785E4E0418B645" xlink:to="loc_us-gaap_DefinedBenefitPlanPlanAssetsForeignCurrencyTranslationGainLoss_A6CD22F6A365CD0C77DD5E4E0419431F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DefinedBenefitPlanFundedStatusOfPlan" xlink:label="loc_us-gaap_DefinedBenefitPlanFundedStatusOfPlan_8FF7AA13EDD0D479DF465E4E0419A334" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansTableTextBlockLineItems_8FEFCE39273326DE20E65E4E0416DDD9" xlink:to="loc_us-gaap_DefinedBenefitPlanFundedStatusOfPlan_8FF7AA13EDD0D479DF465E4E0419A334" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DefinedBenefitPlanAccumulatedOtherComprehensiveIncomeNetGainsLossesBeforeTax" xlink:label="loc_us-gaap_DefinedBenefitPlanAccumulatedOtherComprehensiveIncomeNetGainsLossesBeforeTax_70BF56CCE9537A2D2F3F5E4E04192493" xlink:type="locator" />
    <link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansTableTextBlockLineItems_8FEFCE39273326DE20E65E4E0416DDD9" xlink:to="loc_us-gaap_DefinedBenefitPlanAccumulatedOtherComprehensiveIncomeNetGainsLossesBeforeTax_70BF56CCE9537A2D2F3F5E4E04192493" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DefinedBenefitPlanAccumulatedOtherComprehensiveIncomeNetPriorServiceCostCreditBeforeTax" xlink:label="loc_us-gaap_DefinedBenefitPlanAccumulatedOtherComprehensiveIncomeNetPriorServiceCostCreditBeforeTax_1C518BEB31A22C65CAF55E4E041AB0C5" xlink:type="locator" />
    <link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansTableTextBlockLineItems_8FEFCE39273326DE20E65E4E0416DDD9" xlink:to="loc_us-gaap_DefinedBenefitPlanAccumulatedOtherComprehensiveIncomeNetPriorServiceCostCreditBeforeTax_1C518BEB31A22C65CAF55E4E041AB0C5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DefinedBenefitPlanAmountsRecognizedInBalanceSheet" xlink:label="loc_us-gaap_DefinedBenefitPlanAmountsRecognizedInBalanceSheet_96BD89BCC35F5B0C701B5E4E041A55C2" xlink:type="locator" />
    <link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansTableTextBlockLineItems_8FEFCE39273326DE20E65E4E0416DDD9" xlink:to="loc_us-gaap_DefinedBenefitPlanAmountsRecognizedInBalanceSheet_96BD89BCC35F5B0C701B5E4E041A55C2" xlink:type="arc" />
  </link:definitionLink>
  <link:definitionLink xlink:role="http://www.lilly.com/role/RetirementBenefitsScheduleOfComponentsInConsolidatedBalanceSheetsDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansTableTextBlockLineItems" xlink:label="loc_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansTableTextBlockLineItems_E8AFF580AE3D5321E69FED93D8ED2511" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansDisclosuresTable" xlink:label="loc_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansDisclosuresTable_F88F4931A1AD51AFEF7AED93D8ECD078" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansTableTextBlockLineItems_E8AFF580AE3D5321E69FED93D8ED2511" xlink:to="loc_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansDisclosuresTable_F88F4931A1AD51AFEF7AED93D8ECD078" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RetirementPlanTypeAxis" xlink:label="loc_us-gaap_RetirementPlanTypeAxis_D468EB9CADCDC9BDA0D5ED93D8ECD816" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansDisclosuresTable_F88F4931A1AD51AFEF7AED93D8ECD078" xlink:to="loc_us-gaap_RetirementPlanTypeAxis_D468EB9CADCDC9BDA0D5ED93D8ECD816" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RetirementPlanTypeDomain" xlink:label="loc_us-gaap_RetirementPlanTypeDomain_43156F93B00FF2DF0661ED93D8EDDD78_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RetirementPlanTypeAxis_D468EB9CADCDC9BDA0D5ED93D8ECD816" xlink:to="loc_us-gaap_RetirementPlanTypeDomain_43156F93B00FF2DF0661ED93D8EDDD78_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RetirementPlanTypeDomain" xlink:label="loc_us-gaap_RetirementPlanTypeDomain_43156F93B00FF2DF0661ED93D8EDDD78" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RetirementPlanTypeAxis_D468EB9CADCDC9BDA0D5ED93D8ECD816" xlink:to="loc_us-gaap_RetirementPlanTypeDomain_43156F93B00FF2DF0661ED93D8EDDD78" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PensionPlansDefinedBenefitMember" xlink:label="loc_us-gaap_PensionPlansDefinedBenefitMember_C98FC794A175A172791AED93D8ED41C5" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RetirementPlanTypeDomain_43156F93B00FF2DF0661ED93D8EDDD78" xlink:to="loc_us-gaap_PensionPlansDefinedBenefitMember_C98FC794A175A172791AED93D8ED41C5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DefinedBenefitPostretirementHealthCoverageMember" xlink:label="loc_us-gaap_DefinedBenefitPostretirementHealthCoverageMember_C0AED98E2F55D49B9D6AED93D8EDA863" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RetirementPlanTypeDomain_43156F93B00FF2DF0661ED93D8EDDD78" xlink:to="loc_us-gaap_DefinedBenefitPostretirementHealthCoverageMember_C0AED98E2F55D49B9D6AED93D8EDA863" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DefinedBenefitPlanAmountsRecognizedInBalanceSheetAbstract" xlink:label="loc_us-gaap_DefinedBenefitPlanAmountsRecognizedInBalanceSheetAbstract_6DD241F280451997F9E6EDA7AB37467D" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansTableTextBlockLineItems_E8AFF580AE3D5321E69FED93D8ED2511" xlink:to="loc_us-gaap_DefinedBenefitPlanAmountsRecognizedInBalanceSheetAbstract_6DD241F280451997F9E6EDA7AB37467D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DefinedBenefitPlanAssetsForPlanBenefitsNoncurrent" xlink:label="loc_us-gaap_DefinedBenefitPlanAssetsForPlanBenefitsNoncurrent_D195A86A05282D7FEC94ED93D8EEB900" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanAmountsRecognizedInBalanceSheetAbstract_6DD241F280451997F9E6EDA7AB37467D" xlink:to="loc_us-gaap_DefinedBenefitPlanAssetsForPlanBenefitsNoncurrent_D195A86A05282D7FEC94ED93D8EEB900" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PensionAndOtherPostretirementDefinedBenefitPlansCurrentLiabilities" xlink:label="loc_us-gaap_PensionAndOtherPostretirementDefinedBenefitPlansCurrentLiabilities_5181C6FFB59FBC6E38BCED93D8EEDF04" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanAmountsRecognizedInBalanceSheetAbstract_6DD241F280451997F9E6EDA7AB37467D" xlink:to="loc_us-gaap_PensionAndOtherPostretirementDefinedBenefitPlansCurrentLiabilities_5181C6FFB59FBC6E38BCED93D8EEDF04" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PensionAndOtherPostretirementDefinedBenefitPlansLiabilitiesNoncurrent" xlink:label="loc_us-gaap_PensionAndOtherPostretirementDefinedBenefitPlansLiabilitiesNoncurrent_97E2DD337C130A26D647ED93D8EEF726" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanAmountsRecognizedInBalanceSheetAbstract_6DD241F280451997F9E6EDA7AB37467D" xlink:to="loc_us-gaap_PensionAndOtherPostretirementDefinedBenefitPlansLiabilitiesNoncurrent_97E2DD337C130A26D647ED93D8EEF726" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DefinedBenefitPlanAccumulatedOtherComprehensiveIncomeBeforeTax" xlink:label="loc_us-gaap_DefinedBenefitPlanAccumulatedOtherComprehensiveIncomeBeforeTax_5059FCD6FFF80FC71A94ED93D8EE50B5" xlink:type="locator" />
    <link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanAmountsRecognizedInBalanceSheetAbstract_6DD241F280451997F9E6EDA7AB37467D" xlink:to="loc_us-gaap_DefinedBenefitPlanAccumulatedOtherComprehensiveIncomeBeforeTax_5059FCD6FFF80FC71A94ED93D8EE50B5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DefinedBenefitPlanAmountsRecognizedInBalanceSheet" xlink:label="loc_us-gaap_DefinedBenefitPlanAmountsRecognizedInBalanceSheet_5E0B158C98A3E4BF7E79ED93D8EEF803" xlink:type="locator" />
    <link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanAmountsRecognizedInBalanceSheetAbstract_6DD241F280451997F9E6EDA7AB37467D" xlink:to="loc_us-gaap_DefinedBenefitPlanAmountsRecognizedInBalanceSheet_5E0B158C98A3E4BF7E79ED93D8EEF803" xlink:type="arc" />
  </link:definitionLink>
  <link:definitionLink xlink:role="http://www.lilly.com/role/RetirementBenefitsScheduleOfExpectedBenefitPaymentsContributionsAndExpenseDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansTableTextBlockLineItems" xlink:label="loc_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansTableTextBlockLineItems_4F2FC5037B8DF502260EED93D8C75B4A" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansDisclosuresTable" xlink:label="loc_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansDisclosuresTable_9B2F6B4264B448714E44ED93D8C5F4ED" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansTableTextBlockLineItems_4F2FC5037B8DF502260EED93D8C75B4A" xlink:to="loc_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansDisclosuresTable_9B2F6B4264B448714E44ED93D8C5F4ED" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RetirementPlanTypeAxis" xlink:label="loc_us-gaap_RetirementPlanTypeAxis_422CBDBC5B89E38157AEED93D8C6C835" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansDisclosuresTable_9B2F6B4264B448714E44ED93D8C5F4ED" xlink:to="loc_us-gaap_RetirementPlanTypeAxis_422CBDBC5B89E38157AEED93D8C6C835" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RetirementPlanTypeDomain" xlink:label="loc_us-gaap_RetirementPlanTypeDomain_52C354A7E00D9BB3A915ED93D8C61119_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RetirementPlanTypeAxis_422CBDBC5B89E38157AEED93D8C6C835" xlink:to="loc_us-gaap_RetirementPlanTypeDomain_52C354A7E00D9BB3A915ED93D8C61119_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RetirementPlanTypeDomain" xlink:label="loc_us-gaap_RetirementPlanTypeDomain_52C354A7E00D9BB3A915ED93D8C61119" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RetirementPlanTypeAxis_422CBDBC5B89E38157AEED93D8C6C835" xlink:to="loc_us-gaap_RetirementPlanTypeDomain_52C354A7E00D9BB3A915ED93D8C61119" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PensionPlansDefinedBenefitMember" xlink:label="loc_us-gaap_PensionPlansDefinedBenefitMember_08755A1854322371782CED93D8C6F866" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RetirementPlanTypeDomain_52C354A7E00D9BB3A915ED93D8C61119" xlink:to="loc_us-gaap_PensionPlansDefinedBenefitMember_08755A1854322371782CED93D8C6F866" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DefinedBenefitPostretirementHealthCoverageMember" xlink:label="loc_us-gaap_DefinedBenefitPostretirementHealthCoverageMember_7243D2EE995971ECCC56ED93D8C6C8AF" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RetirementPlanTypeDomain_52C354A7E00D9BB3A915ED93D8C61119" xlink:to="loc_us-gaap_DefinedBenefitPostretirementHealthCoverageMember_7243D2EE995971ECCC56ED93D8C6C8AF" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DefinedBenefitPlanEstimatedFutureBenefitPaymentsAbstract" xlink:label="loc_us-gaap_DefinedBenefitPlanEstimatedFutureBenefitPaymentsAbstract_476537A901D51E2985A3ED93D8C7C28E" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansTableTextBlockLineItems_4F2FC5037B8DF502260EED93D8C75B4A" xlink:to="loc_us-gaap_DefinedBenefitPlanEstimatedFutureBenefitPaymentsAbstract_476537A901D51E2985A3ED93D8C7C28E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsNextTwelveMonths" xlink:label="loc_us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsNextTwelveMonths_6F737B8CFCA4D28AAF8CED93D8C78087" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanEstimatedFutureBenefitPaymentsAbstract_476537A901D51E2985A3ED93D8C7C28E" xlink:to="loc_us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsNextTwelveMonths_6F737B8CFCA4D28AAF8CED93D8C78087" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsYearTwo" xlink:label="loc_us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsYearTwo_07F323DB2C13250FC717ED93D8C780E5" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanEstimatedFutureBenefitPaymentsAbstract_476537A901D51E2985A3ED93D8C7C28E" xlink:to="loc_us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsYearTwo_07F323DB2C13250FC717ED93D8C780E5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsYearThree" xlink:label="loc_us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsYearThree_E697DB20583C00972C52ED93D8C8BFEB" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanEstimatedFutureBenefitPaymentsAbstract_476537A901D51E2985A3ED93D8C7C28E" xlink:to="loc_us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsYearThree_E697DB20583C00972C52ED93D8C8BFEB" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsYearFour" xlink:label="loc_us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsYearFour_57D3898BAEBD31C867FAED93D8C8C162" xlink:type="locator" />
    <link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanEstimatedFutureBenefitPaymentsAbstract_476537A901D51E2985A3ED93D8C7C28E" xlink:to="loc_us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsYearFour_57D3898BAEBD31C867FAED93D8C8C162" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsYearFive" xlink:label="loc_us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsYearFive_F7FC67C1E8B7C0C1C0B2ED93D8C889D4" xlink:type="locator" />
    <link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanEstimatedFutureBenefitPaymentsAbstract_476537A901D51E2985A3ED93D8C7C28E" xlink:to="loc_us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsYearFive_F7FC67C1E8B7C0C1C0B2ED93D8C889D4" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsFiveFiscalYearsThereafter" xlink:label="loc_us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsFiveFiscalYearsThereafter_91EB0B2C9707DD130D51ED93D8C838A2" xlink:type="locator" />
    <link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanEstimatedFutureBenefitPaymentsAbstract_476537A901D51E2985A3ED93D8C7C28E" xlink:to="loc_us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsFiveFiscalYearsThereafter_91EB0B2C9707DD130D51ED93D8C838A2" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DefinedBenefitPlanPlansWithBenefitObligationsInExcessOfPlanAssetsAbstract" xlink:label="loc_us-gaap_DefinedBenefitPlanPlansWithBenefitObligationsInExcessOfPlanAssetsAbstract_0A9D3793E0A634DE9F80ED93D8C8E337" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansTableTextBlockLineItems_4F2FC5037B8DF502260EED93D8C75B4A" xlink:to="loc_us-gaap_DefinedBenefitPlanPlansWithBenefitObligationsInExcessOfPlanAssetsAbstract_0A9D3793E0A634DE9F80ED93D8C8E337" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DefinedBenefitPlanPensionPlansWithAccumulatedBenefitObligationsInExcessOfPlanAssetsAggregateProjectedBenefitObligation" xlink:label="loc_us-gaap_DefinedBenefitPlanPensionPlansWithAccumulatedBenefitObligationsInExcessOfPlanAssetsAggregateProjectedBenefitObligation_2FD4883275B17571E073ED93D8C8AF01" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanPlansWithBenefitObligationsInExcessOfPlanAssetsAbstract_0A9D3793E0A634DE9F80ED93D8C8E337" xlink:to="loc_us-gaap_DefinedBenefitPlanPensionPlansWithAccumulatedBenefitObligationsInExcessOfPlanAssetsAggregateProjectedBenefitObligation_2FD4883275B17571E073ED93D8C8AF01" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DefinedBenefitPlanPensionPlansWithAccumulatedBenefitObligationsInExcessOfPlanAssetsAggregateFairValueOfPlanAssets" xlink:label="loc_us-gaap_DefinedBenefitPlanPensionPlansWithAccumulatedBenefitObligationsInExcessOfPlanAssetsAggregateFairValueOfPlanAssets_316EC52A125457F2395EED93D8C9A907" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanPlansWithBenefitObligationsInExcessOfPlanAssetsAbstract_0A9D3793E0A634DE9F80ED93D8C8E337" xlink:to="loc_us-gaap_DefinedBenefitPlanPensionPlansWithAccumulatedBenefitObligationsInExcessOfPlanAssetsAggregateFairValueOfPlanAssets_316EC52A125457F2395EED93D8C9A907" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DefinedBenefitPlanPensionPlansWithAccumulatedBenefitObligationsInExcessOfPlanAssetsAbstract" xlink:label="loc_us-gaap_DefinedBenefitPlanPensionPlansWithAccumulatedBenefitObligationsInExcessOfPlanAssetsAbstract_B62B49ECAA104A72CC20ED93D8C93550" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansTableTextBlockLineItems_4F2FC5037B8DF502260EED93D8C75B4A" xlink:to="loc_us-gaap_DefinedBenefitPlanPensionPlansWithAccumulatedBenefitObligationsInExcessOfPlanAssetsAbstract_B62B49ECAA104A72CC20ED93D8C93550" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DefinedBenefitPlanPensionPlansWithAccumulatedBenefitObligationsInExcessOfPlanAssetsAggregateAccumulatedBenefitObligation" xlink:label="loc_us-gaap_DefinedBenefitPlanPensionPlansWithAccumulatedBenefitObligationsInExcessOfPlanAssetsAggregateAccumulatedBenefitObligation_E86A8866AA2D40A02521ED93D8C93789" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanPensionPlansWithAccumulatedBenefitObligationsInExcessOfPlanAssetsAbstract_B62B49ECAA104A72CC20ED93D8C93550" xlink:to="loc_us-gaap_DefinedBenefitPlanPensionPlansWithAccumulatedBenefitObligationsInExcessOfPlanAssetsAggregateAccumulatedBenefitObligation_E86A8866AA2D40A02521ED93D8C93789" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DefinedBenefitPlanNetPeriodicBenefitCostAbstract" xlink:label="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCostAbstract_4F22EC9DF6242D970D13ED93D8C972E7" xlink:type="locator" />
    <link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansTableTextBlockLineItems_4F2FC5037B8DF502260EED93D8C75B4A" xlink:to="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCostAbstract_4F22EC9DF6242D970D13ED93D8C972E7" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DefinedBenefitPlanServiceCost" xlink:label="loc_us-gaap_DefinedBenefitPlanServiceCost_68A71831868A8896BA32ED93D8CA40DA" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCostAbstract_4F22EC9DF6242D970D13ED93D8C972E7" xlink:to="loc_us-gaap_DefinedBenefitPlanServiceCost_68A71831868A8896BA32ED93D8CA40DA" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DefinedBenefitPlanInterestCost" xlink:label="loc_us-gaap_DefinedBenefitPlanInterestCost_987E8D261AF125EBB610ED93D8CAC260" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCostAbstract_4F22EC9DF6242D970D13ED93D8C972E7" xlink:to="loc_us-gaap_DefinedBenefitPlanInterestCost_987E8D261AF125EBB610ED93D8CAC260" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DefinedBenefitPlanExpectedReturnOnPlanAssets" xlink:label="loc_us-gaap_DefinedBenefitPlanExpectedReturnOnPlanAssets_F13BE05D768E63CBD25FED93D8CA5B08" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCostAbstract_4F22EC9DF6242D970D13ED93D8C972E7" xlink:to="loc_us-gaap_DefinedBenefitPlanExpectedReturnOnPlanAssets_F13BE05D768E63CBD25FED93D8CA5B08" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DefinedBenefitPlanAmortizationOfPriorServiceCostCredit" xlink:label="loc_us-gaap_DefinedBenefitPlanAmortizationOfPriorServiceCostCredit_5AAC89D33E149903B268ED93D8CAB05C" xlink:type="locator" />
    <link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCostAbstract_4F22EC9DF6242D970D13ED93D8C972E7" xlink:to="loc_us-gaap_DefinedBenefitPlanAmortizationOfPriorServiceCostCredit_5AAC89D33E149903B268ED93D8CAB05C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DefinedBenefitPlanAmortizationOfGainsLosses" xlink:label="loc_us-gaap_DefinedBenefitPlanAmortizationOfGainsLosses_7C3CAF47AFCBAA3226A5ED93D8CA0E29" xlink:type="locator" />
    <link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCostAbstract_4F22EC9DF6242D970D13ED93D8C972E7" xlink:to="loc_us-gaap_DefinedBenefitPlanAmortizationOfGainsLosses_7C3CAF47AFCBAA3226A5ED93D8CA0E29" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DefinedBenefitPlanRecognizedNetGainLossDueToCurtailments" xlink:label="loc_us-gaap_DefinedBenefitPlanRecognizedNetGainLossDueToCurtailments_E7C6241DDF5BF5132434ED93D8CBD6FA" xlink:type="locator" />
    <link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCostAbstract_4F22EC9DF6242D970D13ED93D8C972E7" xlink:to="loc_us-gaap_DefinedBenefitPlanRecognizedNetGainLossDueToCurtailments_E7C6241DDF5BF5132434ED93D8CBD6FA" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_DefinedBenefitPlanNetPeriodicBenefitCostCreditGainLossDuetoSpecialTerminationBenefits" xlink:label="loc_lly_DefinedBenefitPlanNetPeriodicBenefitCostCreditGainLossDuetoSpecialTerminationBenefits_EF1E9B179EFAA247D541ED93D8CB8C58" xlink:type="locator" />
    <link:definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCostAbstract_4F22EC9DF6242D970D13ED93D8C972E7" xlink:to="loc_lly_DefinedBenefitPlanNetPeriodicBenefitCostCreditGainLossDuetoSpecialTerminationBenefits_EF1E9B179EFAA247D541ED93D8CB8C58" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost" xlink:label="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost_30228FC6866ED7BC2E05ED93D8CBFC4F" xlink:type="locator" />
    <link:definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCostAbstract_4F22EC9DF6242D970D13ED93D8C972E7" xlink:to="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost_30228FC6866ED7BC2E05ED93D8CBFC4F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansAdjustmentBeforeReclassificationAdjustmentsAndTaxAbstract" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansAdjustmentBeforeReclassificationAdjustmentsAndTaxAbstract_CC4E6EC198FE1FFFCEE7ED93D8CB2208" xlink:type="locator" />
    <link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansTableTextBlockLineItems_4F2FC5037B8DF502260EED93D8C75B4A" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansAdjustmentBeforeReclassificationAdjustmentsAndTaxAbstract_CC4E6EC198FE1FFFCEE7ED93D8CB2208" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansNetUnamortizedGainLossArisingDuringPeriodBeforeTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansNetUnamortizedGainLossArisingDuringPeriodBeforeTax_C9B660B26FBA39394F9FED93D8CC9FA4" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansAdjustmentBeforeReclassificationAdjustmentsAndTaxAbstract_CC4E6EC198FE1FFFCEE7ED93D8CB2208" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansNetUnamortizedGainLossArisingDuringPeriodBeforeTax_C9B660B26FBA39394F9FED93D8CC9FA4" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherComprehensiveIncomeDefinedBenefitPlanNetPriorServiceCostCreditArisingDuringPeriodBeforeTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeDefinedBenefitPlanNetPriorServiceCostCreditArisingDuringPeriodBeforeTax_3274A3096AA60BD0443BED93D8CC9492" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansAdjustmentBeforeReclassificationAdjustmentsAndTaxAbstract_CC4E6EC198FE1FFFCEE7ED93D8CB2208" xlink:to="loc_us-gaap_OtherComprehensiveIncomeDefinedBenefitPlanNetPriorServiceCostCreditArisingDuringPeriodBeforeTax_3274A3096AA60BD0443BED93D8CC9492" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossFinalizationOfPensionAndNonPensionPostretirementPlanValuationBeforeTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossFinalizationOfPensionAndNonPensionPostretirementPlanValuationBeforeTax_184A72CB81375F0E8AB5ED93D8CC99DE" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansAdjustmentBeforeReclassificationAdjustmentsAndTaxAbstract_CC4E6EC198FE1FFFCEE7ED93D8CB2208" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossFinalizationOfPensionAndNonPensionPostretirementPlanValuationBeforeTax_184A72CB81375F0E8AB5ED93D8CC99DE" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossAmortizationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansForNetPriorServiceCostCreditBeforeTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossAmortizationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansForNetPriorServiceCostCreditBeforeTax_7E0709080831BBBFBC65ED93D8CC329F" xlink:type="locator" />
    <link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansAdjustmentBeforeReclassificationAdjustmentsAndTaxAbstract_CC4E6EC198FE1FFFCEE7ED93D8CB2208" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossAmortizationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansForNetPriorServiceCostCreditBeforeTax_7E0709080831BBBFBC65ED93D8CC329F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DefinedBenefitPlanAmountsRecognizedInOtherComprehensiveIncomeLossNetGainLossBeforeTax" xlink:label="loc_us-gaap_DefinedBenefitPlanAmountsRecognizedInOtherComprehensiveIncomeLossNetGainLossBeforeTax_1BBAC7F190441AF10FF9ED93D8CCC8E2" xlink:type="locator" />
    <link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansAdjustmentBeforeReclassificationAdjustmentsAndTaxAbstract_CC4E6EC198FE1FFFCEE7ED93D8CB2208" xlink:to="loc_us-gaap_DefinedBenefitPlanAmountsRecognizedInOtherComprehensiveIncomeLossNetGainLossBeforeTax_1BBAC7F190441AF10FF9ED93D8CCC8E2" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentBeforeTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentBeforeTax_35CD41A9B5A652E6C5A0ED93D8CD0D39" xlink:type="locator" />
    <link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansAdjustmentBeforeReclassificationAdjustmentsAndTaxAbstract_CC4E6EC198FE1FFFCEE7ED93D8CB2208" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentBeforeTax_35CD41A9B5A652E6C5A0ED93D8CD0D39" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansAdjustmentBeforeTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansAdjustmentBeforeTax_04D30BAB11E410D386CBED93D8CDA996" xlink:type="locator" />
    <link:definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansAdjustmentBeforeReclassificationAdjustmentsAndTaxAbstract_CC4E6EC198FE1FFFCEE7ED93D8CB2208" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansAdjustmentBeforeTax_04D30BAB11E410D386CBED93D8CDA996" xlink:type="arc" />
  </link:definitionLink>
  <link:definitionLink xlink:role="http://www.lilly.com/role/RetirementBenefitsScheduleOfFairValueDisclosuresDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansTableTextBlockLineItems" xlink:label="loc_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansTableTextBlockLineItems_20ECDF87E9A6596F6613ED93D8A9381C" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansDisclosuresTable" xlink:label="loc_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansDisclosuresTable_518A3C106B4E1F7C40D0ED93D89EE047" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansTableTextBlockLineItems_20ECDF87E9A6596F6613ED93D8A9381C" xlink:to="loc_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansDisclosuresTable_518A3C106B4E1F7C40D0ED93D89EE047" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment" />
    <link:loc xlink:href="lly-20191231.xsd#lly_FairValueRetirementBenefitsInvestmentsAxis" xlink:label="loc_lly_FairValueRetirementBenefitsInvestmentsAxis_E9E425430A9C4376B4B7ED93D89E141A" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansDisclosuresTable_518A3C106B4E1F7C40D0ED93D89EE047" xlink:to="loc_lly_FairValueRetirementBenefitsInvestmentsAxis_E9E425430A9C4376B4B7ED93D89E141A" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_FairValueRetirementBenefitsInvestmentsDomain" xlink:label="loc_lly_FairValueRetirementBenefitsInvestmentsDomain_5ABDA98E3F4C368E1D27ED93D89F2B45_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_lly_FairValueRetirementBenefitsInvestmentsAxis_E9E425430A9C4376B4B7ED93D89E141A" xlink:to="loc_lly_FairValueRetirementBenefitsInvestmentsDomain_5ABDA98E3F4C368E1D27ED93D89F2B45_default" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_FairValueRetirementBenefitsInvestmentsDomain" xlink:label="loc_lly_FairValueRetirementBenefitsInvestmentsDomain_5ABDA98E3F4C368E1D27ED93D89F2B45" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_lly_FairValueRetirementBenefitsInvestmentsAxis_E9E425430A9C4376B4B7ED93D89E141A" xlink:to="loc_lly_FairValueRetirementBenefitsInvestmentsDomain_5ABDA98E3F4C368E1D27ED93D89F2B45" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_FairValueRetirementBenefitsInvestmentsValuedatNetAssetValueMember" xlink:label="loc_lly_FairValueRetirementBenefitsInvestmentsValuedatNetAssetValueMember_D257F7190052B028A8C3ED93D89FEE52" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lly_FairValueRetirementBenefitsInvestmentsDomain_5ABDA98E3F4C368E1D27ED93D89F2B45" xlink:to="loc_lly_FairValueRetirementBenefitsInvestmentsValuedatNetAssetValueMember_D257F7190052B028A8C3ED93D89FEE52" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_13ADCAF328CD2F79E88AED93D89F2347" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansDisclosuresTable_518A3C106B4E1F7C40D0ED93D89EE047" xlink:to="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_13ADCAF328CD2F79E88AED93D89F2347" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_F0C6781D6CA4A42105E6ED93D89F166F_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_13ADCAF328CD2F79E88AED93D89F2347" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_F0C6781D6CA4A42105E6ED93D89F166F_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_F0C6781D6CA4A42105E6ED93D89F166F" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_13ADCAF328CD2F79E88AED93D89F2347" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_F0C6781D6CA4A42105E6ED93D89F166F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueInputsLevel1Member" xlink:label="loc_us-gaap_FairValueInputsLevel1Member_9B8D671BA409C087EF0DED93D8A02107" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_F0C6781D6CA4A42105E6ED93D89F166F" xlink:to="loc_us-gaap_FairValueInputsLevel1Member_9B8D671BA409C087EF0DED93D8A02107" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueInputsLevel2Member" xlink:label="loc_us-gaap_FairValueInputsLevel2Member_F944FFC1D22C6CEE9886ED93D8A086BB" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_F0C6781D6CA4A42105E6ED93D89F166F" xlink:to="loc_us-gaap_FairValueInputsLevel2Member_F944FFC1D22C6CEE9886ED93D8A086BB" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FairValueInputsLevel3Member" xlink:label="loc_us-gaap_FairValueInputsLevel3Member_75D747D7FB65D21ECAA4ED93D8A07DE0" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_F0C6781D6CA4A42105E6ED93D89F166F" xlink:to="loc_us-gaap_FairValueInputsLevel3Member_75D747D7FB65D21ECAA4ED93D8A07DE0" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DefinedBenefitPlanByPlanAssetCategoriesAxis" xlink:label="loc_us-gaap_DefinedBenefitPlanByPlanAssetCategoriesAxis_666F0CB4197C016A0DEEED93D8A09FAA" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansDisclosuresTable_518A3C106B4E1F7C40D0ED93D89EE047" xlink:to="loc_us-gaap_DefinedBenefitPlanByPlanAssetCategoriesAxis_666F0CB4197C016A0DEEED93D8A09FAA" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PlanAssetCategoriesDomain" xlink:label="loc_us-gaap_PlanAssetCategoriesDomain_C2E3974BBB8256BF49D7ED93D8A12C15_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DefinedBenefitPlanByPlanAssetCategoriesAxis_666F0CB4197C016A0DEEED93D8A09FAA" xlink:to="loc_us-gaap_PlanAssetCategoriesDomain_C2E3974BBB8256BF49D7ED93D8A12C15_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PlanAssetCategoriesDomain" xlink:label="loc_us-gaap_PlanAssetCategoriesDomain_C2E3974BBB8256BF49D7ED93D8A12C15" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DefinedBenefitPlanByPlanAssetCategoriesAxis_666F0CB4197C016A0DEEED93D8A09FAA" xlink:to="loc_us-gaap_PlanAssetCategoriesDomain_C2E3974BBB8256BF49D7ED93D8A12C15" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DefinedBenefitPlanEquitySecuritiesUsMember" xlink:label="loc_us-gaap_DefinedBenefitPlanEquitySecuritiesUsMember_97FA5A52E26B70E9829DED93D8A18DB7" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PlanAssetCategoriesDomain_C2E3974BBB8256BF49D7ED93D8A12C15" xlink:to="loc_us-gaap_DefinedBenefitPlanEquitySecuritiesUsMember_97FA5A52E26B70E9829DED93D8A18DB7" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DefinedBenefitPlanEquitySecuritiesNonUsMember" xlink:label="loc_us-gaap_DefinedBenefitPlanEquitySecuritiesNonUsMember_D9FD78E757EE8F53C831ED93D8A13224" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PlanAssetCategoriesDomain_C2E3974BBB8256BF49D7ED93D8A12C15" xlink:to="loc_us-gaap_DefinedBenefitPlanEquitySecuritiesNonUsMember_D9FD78E757EE8F53C831ED93D8A13224" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FixedIncomeFundsMember" xlink:label="loc_us-gaap_FixedIncomeFundsMember_DE8CBC6650A79CBA7811ED93D8A13EFF" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PlanAssetCategoriesDomain_C2E3974BBB8256BF49D7ED93D8A12C15" xlink:to="loc_us-gaap_FixedIncomeFundsMember_DE8CBC6650A79CBA7811ED93D8A13EFF" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_FixedIncomeFundsRepurchasedAgreementsMember" xlink:label="loc_lly_FixedIncomeFundsRepurchasedAgreementsMember_A2EBFDC21C6599812C31ED93D8A1AFB9" xlink:type="locator" />
    <link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PlanAssetCategoriesDomain_C2E3974BBB8256BF49D7ED93D8A12C15" xlink:to="loc_lly_FixedIncomeFundsRepurchasedAgreementsMember_A2EBFDC21C6599812C31ED93D8A1AFB9" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_FixedIncomeFundsEmergingMarketsMember" xlink:label="loc_lly_FixedIncomeFundsEmergingMarketsMember_70AADA282F0860B7028CED93D8A2D1DA" xlink:type="locator" />
    <link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PlanAssetCategoriesDomain_C2E3974BBB8256BF49D7ED93D8A12C15" xlink:to="loc_lly_FixedIncomeFundsEmergingMarketsMember_70AADA282F0860B7028CED93D8A2D1DA" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_HedgeFundsMember" xlink:label="loc_us-gaap_HedgeFundsMember_5A5B242DB155F3EE1145ED93D8A206B6" xlink:type="locator" />
    <link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PlanAssetCategoriesDomain_C2E3974BBB8256BF49D7ED93D8A12C15" xlink:to="loc_us-gaap_HedgeFundsMember_5A5B242DB155F3EE1145ED93D8A206B6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EquityFundsMember" xlink:label="loc_us-gaap_EquityFundsMember_08DD5F7E8DA97FF08B66ED93D8A24220" xlink:type="locator" />
    <link:definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PlanAssetCategoriesDomain_C2E3974BBB8256BF49D7ED93D8A12C15" xlink:to="loc_us-gaap_EquityFundsMember_08DD5F7E8DA97FF08B66ED93D8A24220" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherContractMember" xlink:label="loc_us-gaap_OtherContractMember_B8391B724F08500A6D57ED93D8A27D23" xlink:type="locator" />
    <link:definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PlanAssetCategoriesDomain_C2E3974BBB8256BF49D7ED93D8A12C15" xlink:to="loc_us-gaap_OtherContractMember_B8391B724F08500A6D57ED93D8A27D23" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DefinedBenefitPlanRealEstateMember" xlink:label="loc_us-gaap_DefinedBenefitPlanRealEstateMember_5687C1A5ABFD160D9DD2ED93D8A24F92" xlink:type="locator" />
    <link:definitionArc order="9" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PlanAssetCategoriesDomain_C2E3974BBB8256BF49D7ED93D8A12C15" xlink:to="loc_us-gaap_DefinedBenefitPlanRealEstateMember_5687C1A5ABFD160D9DD2ED93D8A24F92" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_DefineBenefitPlanOtherMember" xlink:label="loc_lly_DefineBenefitPlanOtherMember_ACAB35636AF12A74A18BED93D8A2848F" xlink:type="locator" />
    <link:definitionArc order="10" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PlanAssetCategoriesDomain_C2E3974BBB8256BF49D7ED93D8A12C15" xlink:to="loc_lly_DefineBenefitPlanOtherMember_ACAB35636AF12A74A18BED93D8A2848F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RetirementPlanTypeAxis" xlink:label="loc_us-gaap_RetirementPlanTypeAxis_E6DD7D28886FD860C6B4ED93D8A37A52" xlink:type="locator" />
    <link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansDisclosuresTable_518A3C106B4E1F7C40D0ED93D89EE047" xlink:to="loc_us-gaap_RetirementPlanTypeAxis_E6DD7D28886FD860C6B4ED93D8A37A52" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RetirementPlanTypeDomain" xlink:label="loc_us-gaap_RetirementPlanTypeDomain_46B157EBAFA0418C0752ED93D8A34E35_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RetirementPlanTypeAxis_E6DD7D28886FD860C6B4ED93D8A37A52" xlink:to="loc_us-gaap_RetirementPlanTypeDomain_46B157EBAFA0418C0752ED93D8A34E35_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RetirementPlanTypeDomain" xlink:label="loc_us-gaap_RetirementPlanTypeDomain_46B157EBAFA0418C0752ED93D8A34E35" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RetirementPlanTypeAxis_E6DD7D28886FD860C6B4ED93D8A37A52" xlink:to="loc_us-gaap_RetirementPlanTypeDomain_46B157EBAFA0418C0752ED93D8A34E35" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PensionPlansDefinedBenefitMember" xlink:label="loc_us-gaap_PensionPlansDefinedBenefitMember_A35F8F32263E1A3FB510ED93D8A87E1F" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RetirementPlanTypeDomain_46B157EBAFA0418C0752ED93D8A34E35" xlink:to="loc_us-gaap_PensionPlansDefinedBenefitMember_A35F8F32263E1A3FB510ED93D8A87E1F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DefinedBenefitPostretirementHealthCoverageMember" xlink:label="loc_us-gaap_DefinedBenefitPostretirementHealthCoverageMember_57CCD25613B4597FC423ED93D8A957BB" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RetirementPlanTypeDomain_46B157EBAFA0418C0752ED93D8A34E35" xlink:to="loc_us-gaap_DefinedBenefitPostretirementHealthCoverageMember_57CCD25613B4597FC423ED93D8A957BB" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DefinedBenefitPlanFairValueOfPlanAssets" xlink:label="loc_us-gaap_DefinedBenefitPlanFairValueOfPlanAssets_6AFC0554A2FB476706D6ED93D8A98BF2" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansTableTextBlockLineItems_20ECDF87E9A6596F6613ED93D8A9381C" xlink:to="loc_us-gaap_DefinedBenefitPlanFairValueOfPlanAssets_6AFC0554A2FB476706D6ED93D8A98BF2" xlink:type="arc" />
  </link:definitionLink>
  <link:definitionLink xlink:role="http://www.lilly.com/role/RetirementBenefitsScheduleOfWeightedAverageAssumptionsDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansTableTextBlockLineItems" xlink:label="loc_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansTableTextBlockLineItems_C1F893D57E5ED73C1872ED93D8E0594E" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansDisclosuresTable" xlink:label="loc_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansDisclosuresTable_78C86ED9D49DC80CD3AFED93D8DE0E33" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansTableTextBlockLineItems_C1F893D57E5ED73C1872ED93D8E0594E" xlink:to="loc_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansDisclosuresTable_78C86ED9D49DC80CD3AFED93D8DE0E33" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RetirementPlanTypeAxis" xlink:label="loc_us-gaap_RetirementPlanTypeAxis_AEA400ECFAD0FB50B77BED93D8DF716C" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansDisclosuresTable_78C86ED9D49DC80CD3AFED93D8DE0E33" xlink:to="loc_us-gaap_RetirementPlanTypeAxis_AEA400ECFAD0FB50B77BED93D8DF716C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RetirementPlanTypeDomain" xlink:label="loc_us-gaap_RetirementPlanTypeDomain_6084FBD534F661A5221EED93D8DFCE0D_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RetirementPlanTypeAxis_AEA400ECFAD0FB50B77BED93D8DF716C" xlink:to="loc_us-gaap_RetirementPlanTypeDomain_6084FBD534F661A5221EED93D8DFCE0D_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RetirementPlanTypeDomain" xlink:label="loc_us-gaap_RetirementPlanTypeDomain_6084FBD534F661A5221EED93D8DFCE0D" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RetirementPlanTypeAxis_AEA400ECFAD0FB50B77BED93D8DF716C" xlink:to="loc_us-gaap_RetirementPlanTypeDomain_6084FBD534F661A5221EED93D8DFCE0D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PensionPlansDefinedBenefitMember" xlink:label="loc_us-gaap_PensionPlansDefinedBenefitMember_7E4A7E1A319A5601EC5FED93D8DFD0F7" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RetirementPlanTypeDomain_6084FBD534F661A5221EED93D8DFCE0D" xlink:to="loc_us-gaap_PensionPlansDefinedBenefitMember_7E4A7E1A319A5601EC5FED93D8DFD0F7" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DefinedBenefitPostretirementHealthCoverageMember" xlink:label="loc_us-gaap_DefinedBenefitPostretirementHealthCoverageMember_9051E6B309B440C7218CED93D8E03FF1" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RetirementPlanTypeDomain_6084FBD534F661A5221EED93D8DFCE0D" xlink:to="loc_us-gaap_DefinedBenefitPostretirementHealthCoverageMember_9051E6B309B440C7218CED93D8E03FF1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DefinedBenefitPlanAssumptionsUsedCalculatingBenefitObligationDiscountRate" xlink:label="loc_us-gaap_DefinedBenefitPlanAssumptionsUsedCalculatingBenefitObligationDiscountRate_339E9C587A6DF552DAF7ED93D8E0A34C" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansTableTextBlockLineItems_C1F893D57E5ED73C1872ED93D8E0594E" xlink:to="loc_us-gaap_DefinedBenefitPlanAssumptionsUsedCalculatingBenefitObligationDiscountRate_339E9C587A6DF552DAF7ED93D8E0A34C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DefinedBenefitPlanAssumptionsUsedCalculatingNetPeriodicBenefitCostDiscountRate" xlink:label="loc_us-gaap_DefinedBenefitPlanAssumptionsUsedCalculatingNetPeriodicBenefitCostDiscountRate_BD88A8B95CFD3A872ED9ED93D8E05ED0" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansTableTextBlockLineItems_C1F893D57E5ED73C1872ED93D8E0594E" xlink:to="loc_us-gaap_DefinedBenefitPlanAssumptionsUsedCalculatingNetPeriodicBenefitCostDiscountRate_BD88A8B95CFD3A872ED9ED93D8E05ED0" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DefinedBenefitPlanAssumptionsUsedCalculatingBenefitObligationRateOfCompensationIncrease" xlink:label="loc_us-gaap_DefinedBenefitPlanAssumptionsUsedCalculatingBenefitObligationRateOfCompensationIncrease_F983D575D7CD94C79A61ED93D8E07394" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansTableTextBlockLineItems_C1F893D57E5ED73C1872ED93D8E0594E" xlink:to="loc_us-gaap_DefinedBenefitPlanAssumptionsUsedCalculatingBenefitObligationRateOfCompensationIncrease_F983D575D7CD94C79A61ED93D8E07394" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DefinedBenefitPlanAssumptionsUsedCalculatingNetPeriodicBenefitCostRateOfCompensationIncrease" xlink:label="loc_us-gaap_DefinedBenefitPlanAssumptionsUsedCalculatingNetPeriodicBenefitCostRateOfCompensationIncrease_0A083DDCB9B9E9945195ED93D8E1A319" xlink:type="locator" />
    <link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansTableTextBlockLineItems_C1F893D57E5ED73C1872ED93D8E0594E" xlink:to="loc_us-gaap_DefinedBenefitPlanAssumptionsUsedCalculatingNetPeriodicBenefitCostRateOfCompensationIncrease_0A083DDCB9B9E9945195ED93D8E1A319" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DefinedBenefitPlanAssumptionsUsedCalculatingNetPeriodicBenefitCostExpectedLongTermReturnOnAssets" xlink:label="loc_us-gaap_DefinedBenefitPlanAssumptionsUsedCalculatingNetPeriodicBenefitCostExpectedLongTermReturnOnAssets_96A81017B687CC87B8BAED93D8E1C85F" xlink:type="locator" />
    <link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansTableTextBlockLineItems_C1F893D57E5ED73C1872ED93D8E0594E" xlink:to="loc_us-gaap_DefinedBenefitPlanAssumptionsUsedCalculatingNetPeriodicBenefitCostExpectedLongTermReturnOnAssets_96A81017B687CC87B8BAED93D8E1C85F" xlink:type="arc" />
  </link:definitionLink>
  <link:definitionLink xlink:role="http://www.lilly.com/role/RetirementBenefitsTables" xlink:type="extended" />
  <link:definitionLink xlink:role="http://www.lilly.com/role/Revenue" xlink:type="extended" />
  <link:definitionLink xlink:role="http://www.lilly.com/role/RevenueContractLiabilitiesDetails" xlink:type="extended" />
  <link:definitionLink xlink:role="http://www.lilly.com/role/RevenueDisaggregationOfRevenueByGeographicalAreaDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DisaggregationOfRevenueLineItems" xlink:label="loc_us-gaap_DisaggregationOfRevenueLineItems_9CFF1E29132C383224985E4E05C024F8" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DisaggregationOfRevenueTable" xlink:label="loc_us-gaap_DisaggregationOfRevenueTable_CBADFFCEEF764F0ADDB05E4E05B560A8" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_9CFF1E29132C383224985E4E05C024F8" xlink:to="loc_us-gaap_DisaggregationOfRevenueTable_CBADFFCEEF764F0ADDB05E4E05B560A8" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_StatementGeographicalAxis" xlink:label="loc_srt_StatementGeographicalAxis_1D2350E88B7BC3F571AD5E4E05B5BDEE" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_CBADFFCEEF764F0ADDB05E4E05B560A8" xlink:to="loc_srt_StatementGeographicalAxis_1D2350E88B7BC3F571AD5E4E05B5BDEE" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_SegmentGeographicalDomain" xlink:label="loc_srt_SegmentGeographicalDomain_39D5D2877771716B69F15E4E05BF92C2_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_StatementGeographicalAxis_1D2350E88B7BC3F571AD5E4E05B5BDEE" xlink:to="loc_srt_SegmentGeographicalDomain_39D5D2877771716B69F15E4E05BF92C2_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_SegmentGeographicalDomain" xlink:label="loc_srt_SegmentGeographicalDomain_39D5D2877771716B69F15E4E05BF92C2" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_StatementGeographicalAxis_1D2350E88B7BC3F571AD5E4E05B5BDEE" xlink:to="loc_srt_SegmentGeographicalDomain_39D5D2877771716B69F15E4E05BF92C2" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/country/2017/country-2017-01-31.xsd#country_US" xlink:label="loc_country_US_B5F03ED040610816995A5E4E05C0C869" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_39D5D2877771716B69F15E4E05BF92C2" xlink:to="loc_country_US_B5F03ED040610816995A5E4E05C0C869" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_EuropeMember" xlink:label="loc_srt_EuropeMember_5D6AC2AC337BD0E53DC65E4E05C0D6F9" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_39D5D2877771716B69F15E4E05BF92C2" xlink:to="loc_srt_EuropeMember_5D6AC2AC337BD0E53DC65E4E05C0D6F9" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/country/2017/country-2017-01-31.xsd#country_JP" xlink:label="loc_country_JP_EC726BE79175F650B8995E4E05C0A574" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_39D5D2877771716B69F15E4E05BF92C2" xlink:to="loc_country_JP_EC726BE79175F650B8995E4E05C0A574" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_OtherForeignCountriesMember" xlink:label="loc_lly_OtherForeignCountriesMember_4179C299C2330E3A630C5E4E05C0F63E" xlink:type="locator" />
    <link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_39D5D2877771716B69F15E4E05BF92C2" xlink:to="loc_lly_OtherForeignCountriesMember_4179C299C2330E3A630C5E4E05C0F63E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_Revenues" xlink:label="loc_us-gaap_Revenues_14064737A2B721C244CA5E4E05C0BA2B" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_9CFF1E29132C383224985E4E05C024F8" xlink:to="loc_us-gaap_Revenues_14064737A2B721C244CA5E4E05C0BA2B" xlink:type="arc" />
  </link:definitionLink>
  <link:definitionLink xlink:role="http://www.lilly.com/role/RevenueDisaggregationOfRevenueByProductDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DisaggregationOfRevenueLineItems" xlink:label="loc_us-gaap_DisaggregationOfRevenueLineItems_4C917942AC3C60638ED65972FCD65D1B" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DisaggregationOfRevenueTable" xlink:label="loc_us-gaap_DisaggregationOfRevenueTable_EDE67743699A610FD8435972FCCF7C91" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_4C917942AC3C60638ED65972FCD65D1B" xlink:to="loc_us-gaap_DisaggregationOfRevenueTable_EDE67743699A610FD8435972FCCF7C91" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_ProductOrServiceAxis" xlink:label="loc_srt_ProductOrServiceAxis_50A72D72D1D6558B14E65972FCCF4F77" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_EDE67743699A610FD8435972FCCF7C91" xlink:to="loc_srt_ProductOrServiceAxis_50A72D72D1D6558B14E65972FCCF4F77" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_ProductsAndServicesDomain" xlink:label="loc_srt_ProductsAndServicesDomain_152B3BCE7F5D14E008195972FCCF3BB7_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ProductOrServiceAxis_50A72D72D1D6558B14E65972FCCF4F77" xlink:to="loc_srt_ProductsAndServicesDomain_152B3BCE7F5D14E008195972FCCF3BB7_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_ProductsAndServicesDomain" xlink:label="loc_srt_ProductsAndServicesDomain_152B3BCE7F5D14E008195972FCCF3BB7" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ProductOrServiceAxis_50A72D72D1D6558B14E65972FCCF4F77" xlink:to="loc_srt_ProductsAndServicesDomain_152B3BCE7F5D14E008195972FCCF3BB7" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_EndocrinologyMember" xlink:label="loc_lly_EndocrinologyMember_0798A479492CD26AAF4F5972FCCF75AE" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_152B3BCE7F5D14E008195972FCCF3BB7" xlink:to="loc_lly_EndocrinologyMember_0798A479492CD26AAF4F5972FCCF75AE" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_TrulicityMemberMember" xlink:label="loc_lly_TrulicityMemberMember_9219FFD37C552189E82A5972FCD002A2" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lly_EndocrinologyMember_0798A479492CD26AAF4F5972FCCF75AE" xlink:to="loc_lly_TrulicityMemberMember_9219FFD37C552189E82A5972FCD002A2" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_HumalogMember" xlink:label="loc_lly_HumalogMember_4E8372BBA94505B5F3115972FCD0C27B" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lly_EndocrinologyMember_0798A479492CD26AAF4F5972FCCF75AE" xlink:to="loc_lly_HumalogMember_4E8372BBA94505B5F3115972FCD0C27B" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_ForteoMember" xlink:label="loc_lly_ForteoMember_6E4B932C27657230B73E5972FCD0602E" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lly_EndocrinologyMember_0798A479492CD26AAF4F5972FCCF75AE" xlink:to="loc_lly_ForteoMember_6E4B932C27657230B73E5972FCD0602E" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_HumulinMember" xlink:label="loc_lly_HumulinMember_286797254E60B49A81405972FCD07D34" xlink:type="locator" />
    <link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lly_EndocrinologyMember_0798A479492CD26AAF4F5972FCCF75AE" xlink:to="loc_lly_HumulinMember_286797254E60B49A81405972FCD07D34" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_BasaglarMember" xlink:label="loc_lly_BasaglarMember_463500EE8B830CDB18B15972FCD13CEC" xlink:type="locator" />
    <link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lly_EndocrinologyMember_0798A479492CD26AAF4F5972FCCF75AE" xlink:to="loc_lly_BasaglarMember_463500EE8B830CDB18B15972FCD13CEC" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_JardianceMember" xlink:label="loc_lly_JardianceMember_B2E208789A7E13E5DA6A5972FCD1EC29" xlink:type="locator" />
    <link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lly_EndocrinologyMember_0798A479492CD26AAF4F5972FCCF75AE" xlink:to="loc_lly_JardianceMember_B2E208789A7E13E5DA6A5972FCD1EC29" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_TrajentaBIMember" xlink:label="loc_lly_TrajentaBIMember_899DD4BBB6E4AC2E2B2E5972FCD13F42" xlink:type="locator" />
    <link:definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lly_EndocrinologyMember_0798A479492CD26AAF4F5972FCCF75AE" xlink:to="loc_lly_TrajentaBIMember_899DD4BBB6E4AC2E2B2E5972FCD13F42" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_OtherEndocrinologyMember" xlink:label="loc_lly_OtherEndocrinologyMember_AA2ED1149009FCE3AA4B5972FCD1A4BE" xlink:type="locator" />
    <link:definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lly_EndocrinologyMember_0798A479492CD26AAF4F5972FCCF75AE" xlink:to="loc_lly_OtherEndocrinologyMember_AA2ED1149009FCE3AA4B5972FCD1A4BE" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_OncologyMember" xlink:label="loc_lly_OncologyMember_BF6172A2D8B83946E2C15972FCD11BF6" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_152B3BCE7F5D14E008195972FCCF3BB7" xlink:to="loc_lly_OncologyMember_BF6172A2D8B83946E2C15972FCD11BF6" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_AlimtaMember" xlink:label="loc_lly_AlimtaMember_8CC7CB3E42B62FE1F5075972FCD1CAEC" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lly_OncologyMember_BF6172A2D8B83946E2C15972FCD11BF6" xlink:to="loc_lly_AlimtaMember_8CC7CB3E42B62FE1F5075972FCD1CAEC" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_CyramzaMember" xlink:label="loc_lly_CyramzaMember_CDAF4C0428182B5411985972FCD27B29" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lly_OncologyMember_BF6172A2D8B83946E2C15972FCD11BF6" xlink:to="loc_lly_CyramzaMember_CDAF4C0428182B5411985972FCD27B29" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_VerzenioMember" xlink:label="loc_lly_VerzenioMember_394BF756FF692056ECE75972FCD268D4" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lly_OncologyMember_BF6172A2D8B83946E2C15972FCD11BF6" xlink:to="loc_lly_VerzenioMember_394BF756FF692056ECE75972FCD268D4" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_ErbituxMember" xlink:label="loc_lly_ErbituxMember_9364C472A62E62418D435972FCD2BF5A" xlink:type="locator" />
    <link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lly_OncologyMember_BF6172A2D8B83946E2C15972FCD11BF6" xlink:to="loc_lly_ErbituxMember_9364C472A62E62418D435972FCD2BF5A" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_OtherOncologyMember" xlink:label="loc_lly_OtherOncologyMember_28D3FE604723540B41525972FCD2B503" xlink:type="locator" />
    <link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lly_OncologyMember_BF6172A2D8B83946E2C15972FCD11BF6" xlink:to="loc_lly_OtherOncologyMember_28D3FE604723540B41525972FCD2B503" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_ImmunologyMember" xlink:label="loc_lly_ImmunologyMember_BAB664236322EE35A78B5972FCD2A767" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_152B3BCE7F5D14E008195972FCCF3BB7" xlink:to="loc_lly_ImmunologyMember_BAB664236322EE35A78B5972FCD2A767" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_TaltzMember" xlink:label="loc_lly_TaltzMember_8DA80959A5A5B12BDB545972FCD223F5" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lly_ImmunologyMember_BAB664236322EE35A78B5972FCD2A767" xlink:to="loc_lly_TaltzMember_8DA80959A5A5B12BDB545972FCD223F5" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_OlumiantMember" xlink:label="loc_lly_OlumiantMember_C56C9450F84DAF8105435972FCD38F06" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lly_ImmunologyMember_BAB664236322EE35A78B5972FCD2A767" xlink:to="loc_lly_OlumiantMember_C56C9450F84DAF8105435972FCD38F06" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_NeuroscienceMember" xlink:label="loc_lly_NeuroscienceMember_8DD8CC4F631AF93D5E7B5972FCD35495" xlink:type="locator" />
    <link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_152B3BCE7F5D14E008195972FCCF3BB7" xlink:to="loc_lly_NeuroscienceMember_8DD8CC4F631AF93D5E7B5972FCD35495" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_CymbaltaMember" xlink:label="loc_lly_CymbaltaMember_4C88C5748DBBDA402DD85972FCD3C0AA" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lly_NeuroscienceMember_8DD8CC4F631AF93D5E7B5972FCD35495" xlink:to="loc_lly_CymbaltaMember_4C88C5748DBBDA402DD85972FCD3C0AA" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_ZyprexaMember" xlink:label="loc_lly_ZyprexaMember_0B992B4AE7D41FCDD17C5972FCD37FF6" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lly_NeuroscienceMember_8DD8CC4F631AF93D5E7B5972FCD35495" xlink:to="loc_lly_ZyprexaMember_0B992B4AE7D41FCDD17C5972FCD37FF6" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_StratteraMember" xlink:label="loc_lly_StratteraMember_7699FD34F10CACF4589A5972FCD3C20B" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lly_NeuroscienceMember_8DD8CC4F631AF93D5E7B5972FCD35495" xlink:to="loc_lly_StratteraMember_7699FD34F10CACF4589A5972FCD3C20B" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_EmgalityMember" xlink:label="loc_lly_EmgalityMember_4C84C77D76647DCF96805972FCD4F970" xlink:type="locator" />
    <link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lly_NeuroscienceMember_8DD8CC4F631AF93D5E7B5972FCD35495" xlink:to="loc_lly_EmgalityMember_4C84C77D76647DCF96805972FCD4F970" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_OtherNeuroscienceMember" xlink:label="loc_lly_OtherNeuroscienceMember_EF1F09636CAA0FB338175972FCD44B58" xlink:type="locator" />
    <link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lly_NeuroscienceMember_8DD8CC4F631AF93D5E7B5972FCD35495" xlink:to="loc_lly_OtherNeuroscienceMember_EF1F09636CAA0FB338175972FCD44B58" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_OtherProductTotalMember" xlink:label="loc_lly_OtherProductTotalMember_6ED6496C7D3693B6AF205972FCD4C536" xlink:type="locator" />
    <link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_152B3BCE7F5D14E008195972FCCF3BB7" xlink:to="loc_lly_OtherProductTotalMember_6ED6496C7D3693B6AF205972FCD4C536" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_CialisMember" xlink:label="loc_lly_CialisMember_0D0B278C1D666793F9105972FCD48FFD" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lly_OtherProductTotalMember_6ED6496C7D3693B6AF205972FCD4C536" xlink:to="loc_lly_CialisMember_0D0B278C1D666793F9105972FCD48FFD" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_OtherProductMember" xlink:label="loc_lly_OtherProductMember_B8638C9041D526CE409F5972FCD55D15" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lly_OtherProductTotalMember_6ED6496C7D3693B6AF205972FCD4C536" xlink:to="loc_lly_OtherProductMember_B8638C9041D526CE409F5972FCD55D15" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_StatementGeographicalAxis" xlink:label="loc_srt_StatementGeographicalAxis_6961729F2685EC611FA45972FCD5BB59" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_EDE67743699A610FD8435972FCCF7C91" xlink:to="loc_srt_StatementGeographicalAxis_6961729F2685EC611FA45972FCD5BB59" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_SegmentGeographicalDomain" xlink:label="loc_srt_SegmentGeographicalDomain_5F2BFC5E323E1A92BC015972FCD5BA70_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_StatementGeographicalAxis_6961729F2685EC611FA45972FCD5BB59" xlink:to="loc_srt_SegmentGeographicalDomain_5F2BFC5E323E1A92BC015972FCD5BA70_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_SegmentGeographicalDomain" xlink:label="loc_srt_SegmentGeographicalDomain_5F2BFC5E323E1A92BC015972FCD5BA70" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_StatementGeographicalAxis_6961729F2685EC611FA45972FCD5BB59" xlink:to="loc_srt_SegmentGeographicalDomain_5F2BFC5E323E1A92BC015972FCD5BA70" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/country/2017/country-2017-01-31.xsd#country_US" xlink:label="loc_country_US_CD3536AB1F8244D77EF25972FCD543F7" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_5F2BFC5E323E1A92BC015972FCD5BA70" xlink:to="loc_country_US_CD3536AB1F8244D77EF25972FCD543F7" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NonUsMember" xlink:label="loc_us-gaap_NonUsMember_B26C0B3A6DDA6D4DD0DF5972FCD63A6A" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_5F2BFC5E323E1A92BC015972FCD5BA70" xlink:to="loc_us-gaap_NonUsMember_B26C0B3A6DDA6D4DD0DF5972FCD63A6A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_Revenues" xlink:label="loc_us-gaap_Revenues_8D8EB462EB89A0AFEF495972FCD6884D" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_4C917942AC3C60638ED65972FCD65D1B" xlink:to="loc_us-gaap_Revenues_8D8EB462EB89A0AFEF495972FCD6884D" xlink:type="arc" />
  </link:definitionLink>
  <link:definitionLink xlink:role="http://www.lilly.com/role/RevenueNarrativeDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ChangeInAccountingEstimateLineItems" xlink:label="loc_us-gaap_ChangeInAccountingEstimateLineItems_31E95BD977F9F2CB71585972FCE5A35E" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfChangeInAccountingEstimateTable" xlink:label="loc_us-gaap_ScheduleOfChangeInAccountingEstimateTable_B0DFBCAB2D8D2C6BBAC25972FCE03BDD" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ChangeInAccountingEstimateLineItems_31E95BD977F9F2CB71585972FCE5A35E" xlink:to="loc_us-gaap_ScheduleOfChangeInAccountingEstimateTable_B0DFBCAB2D8D2C6BBAC25972FCE03BDD" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_MajorCustomersAxis" xlink:label="loc_srt_MajorCustomersAxis_6E6D164D8F4C56FE8F3B5972FCE172F5" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfChangeInAccountingEstimateTable_B0DFBCAB2D8D2C6BBAC25972FCE03BDD" xlink:to="loc_srt_MajorCustomersAxis_6E6D164D8F4C56FE8F3B5972FCE172F5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_NameOfMajorCustomerDomain" xlink:label="loc_srt_NameOfMajorCustomerDomain_A2B00CF3A306873CBE735972FCE12A9A_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_MajorCustomersAxis_6E6D164D8F4C56FE8F3B5972FCE172F5" xlink:to="loc_srt_NameOfMajorCustomerDomain_A2B00CF3A306873CBE735972FCE12A9A_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_NameOfMajorCustomerDomain" xlink:label="loc_srt_NameOfMajorCustomerDomain_A2B00CF3A306873CBE735972FCE12A9A" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_MajorCustomersAxis_6E6D164D8F4C56FE8F3B5972FCE172F5" xlink:to="loc_srt_NameOfMajorCustomerDomain_A2B00CF3A306873CBE735972FCE12A9A" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_ThreeLargestWholesalesMember" xlink:label="loc_lly_ThreeLargestWholesalesMember_E2F1B8A806DD015272A35972FCE1201A" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_NameOfMajorCustomerDomain_A2B00CF3A306873CBE735972FCE12A9A" xlink:to="loc_lly_ThreeLargestWholesalesMember_E2F1B8A806DD015272A35972FCE1201A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ConcentrationRiskByBenchmarkAxis" xlink:label="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_59FA3E936B878FE84F255972FCE274E6" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfChangeInAccountingEstimateTable_B0DFBCAB2D8D2C6BBAC25972FCE03BDD" xlink:to="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_59FA3E936B878FE84F255972FCE274E6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ConcentrationRiskBenchmarkDomain" xlink:label="loc_us-gaap_ConcentrationRiskBenchmarkDomain_905CAE404F3D90D5BC015972FCE203E9_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_59FA3E936B878FE84F255972FCE274E6" xlink:to="loc_us-gaap_ConcentrationRiskBenchmarkDomain_905CAE404F3D90D5BC015972FCE203E9_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ConcentrationRiskBenchmarkDomain" xlink:label="loc_us-gaap_ConcentrationRiskBenchmarkDomain_905CAE404F3D90D5BC015972FCE203E9" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_59FA3E936B878FE84F255972FCE274E6" xlink:to="loc_us-gaap_ConcentrationRiskBenchmarkDomain_905CAE404F3D90D5BC015972FCE203E9" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SalesRevenueNetMember" xlink:label="loc_us-gaap_SalesRevenueNetMember_62C28CC1E7852A8D1FB95972FCE2F72D" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ConcentrationRiskBenchmarkDomain_905CAE404F3D90D5BC015972FCE203E9" xlink:to="loc_us-gaap_SalesRevenueNetMember_62C28CC1E7852A8D1FB95972FCE2F72D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AccountsReceivableMember" xlink:label="loc_us-gaap_AccountsReceivableMember_E04F53B50C78C6F862135972FCE2C3CD" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ConcentrationRiskBenchmarkDomain_905CAE404F3D90D5BC015972FCE203E9" xlink:to="loc_us-gaap_AccountsReceivableMember_E04F53B50C78C6F862135972FCE2C3CD" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_RangeAxis" xlink:label="loc_srt_RangeAxis_494AF316FC919850A22D5972FCE2B536" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfChangeInAccountingEstimateTable_B0DFBCAB2D8D2C6BBAC25972FCE03BDD" xlink:to="loc_srt_RangeAxis_494AF316FC919850A22D5972FCE2B536" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_RangeMember" xlink:label="loc_srt_RangeMember_E260DE558DF77E3452DF5972FCE346F5_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_494AF316FC919850A22D5972FCE2B536" xlink:to="loc_srt_RangeMember_E260DE558DF77E3452DF5972FCE346F5_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_RangeMember" xlink:label="loc_srt_RangeMember_E260DE558DF77E3452DF5972FCE346F5" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_494AF316FC919850A22D5972FCE2B536" xlink:to="loc_srt_RangeMember_E260DE558DF77E3452DF5972FCE346F5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_MinimumMember" xlink:label="loc_srt_MinimumMember_F0CB4AE7F8EED81117975972FCE3180F" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_E260DE558DF77E3452DF5972FCE346F5" xlink:to="loc_srt_MinimumMember_F0CB4AE7F8EED81117975972FCE3180F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_MaximumMember" xlink:label="loc_srt_MaximumMember_54418814F2C639942B545972FCE3908F" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_E260DE558DF77E3452DF5972FCE346F5" xlink:to="loc_srt_MaximumMember_54418814F2C639942B545972FCE3908F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_StatementGeographicalAxis" xlink:label="loc_srt_StatementGeographicalAxis_127BA5B061D3A2DAFFDC5972FCE3C63D" xlink:type="locator" />
    <link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfChangeInAccountingEstimateTable_B0DFBCAB2D8D2C6BBAC25972FCE03BDD" xlink:to="loc_srt_StatementGeographicalAxis_127BA5B061D3A2DAFFDC5972FCE3C63D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_SegmentGeographicalDomain" xlink:label="loc_srt_SegmentGeographicalDomain_CB83DAD01BB234C9E0E25972FCE324B3_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_StatementGeographicalAxis_127BA5B061D3A2DAFFDC5972FCE3C63D" xlink:to="loc_srt_SegmentGeographicalDomain_CB83DAD01BB234C9E0E25972FCE324B3_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_SegmentGeographicalDomain" xlink:label="loc_srt_SegmentGeographicalDomain_CB83DAD01BB234C9E0E25972FCE324B3" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_StatementGeographicalAxis_127BA5B061D3A2DAFFDC5972FCE3C63D" xlink:to="loc_srt_SegmentGeographicalDomain_CB83DAD01BB234C9E0E25972FCE324B3" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/country/2017/country-2017-01-31.xsd#country_US" xlink:label="loc_country_US_E5AF4586791578C37FFB5972FCE4864C" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_CB83DAD01BB234C9E0E25972FCE324B3" xlink:to="loc_country_US_E5AF4586791578C37FFB5972FCE4864C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ChangeInAccountingEstimateByTypeAxis" xlink:label="loc_us-gaap_ChangeInAccountingEstimateByTypeAxis_065075039C19150403B55972FCE466F9" xlink:type="locator" />
    <link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfChangeInAccountingEstimateTable_B0DFBCAB2D8D2C6BBAC25972FCE03BDD" xlink:to="loc_us-gaap_ChangeInAccountingEstimateByTypeAxis_065075039C19150403B55972FCE466F9" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ChangeInAccountingEstimateTypeDomain" xlink:label="loc_us-gaap_ChangeInAccountingEstimateTypeDomain_EB5BEE5145C4C84A723C5972FCE45C2A_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ChangeInAccountingEstimateByTypeAxis_065075039C19150403B55972FCE466F9" xlink:to="loc_us-gaap_ChangeInAccountingEstimateTypeDomain_EB5BEE5145C4C84A723C5972FCE45C2A_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ChangeInAccountingEstimateTypeDomain" xlink:label="loc_us-gaap_ChangeInAccountingEstimateTypeDomain_EB5BEE5145C4C84A723C5972FCE45C2A" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ChangeInAccountingEstimateByTypeAxis_065075039C19150403B55972FCE466F9" xlink:to="loc_us-gaap_ChangeInAccountingEstimateTypeDomain_EB5BEE5145C4C84A723C5972FCE45C2A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SalesReturnsAndAllowancesMember" xlink:label="loc_us-gaap_SalesReturnsAndAllowancesMember_9791029C48C9F88D1BCC5972FCE4300E" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ChangeInAccountingEstimateTypeDomain_EB5BEE5145C4C84A723C5972FCE45C2A" xlink:to="loc_us-gaap_SalesReturnsAndAllowancesMember_9791029C48C9F88D1BCC5972FCE4300E" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_RevenuefromContractPaymentTermMinimum" xlink:label="loc_lly_RevenuefromContractPaymentTermMinimum_6248B46EE1E94175C6F95972FCE5AFD1" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ChangeInAccountingEstimateLineItems_31E95BD977F9F2CB71585972FCE5A35E" xlink:to="loc_lly_RevenuefromContractPaymentTermMinimum_6248B46EE1E94175C6F95972FCE5AFD1" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_RevenuefromContractPaymentTermMaximum" xlink:label="loc_lly_RevenuefromContractPaymentTermMaximum_CF3DFCE7B6D6CD2115CF5972FCE52340" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ChangeInAccountingEstimateLineItems_31E95BD977F9F2CB71585972FCE5A35E" xlink:to="loc_lly_RevenuefromContractPaymentTermMaximum_CF3DFCE7B6D6CD2115CF5972FCE52340" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_RevenuePerformanceObligationPaymentTermsFinancingComponentPeriodBetweenTransferOfControlAndPaymentReceipt" xlink:label="loc_lly_RevenuePerformanceObligationPaymentTermsFinancingComponentPeriodBetweenTransferOfControlAndPaymentReceipt_214A2487020769D6E5165972FCE53AC7" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ChangeInAccountingEstimateLineItems_31E95BD977F9F2CB71585972FCE5A35E" xlink:to="loc_lly_RevenuePerformanceObligationPaymentTermsFinancingComponentPeriodBetweenTransferOfControlAndPaymentReceipt_214A2487020769D6E5165972FCE53AC7" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ConcentrationRiskPercentage1" xlink:label="loc_us-gaap_ConcentrationRiskPercentage1_CD3260AD6979465566905972FCE6B283" xlink:type="locator" />
    <link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ChangeInAccountingEstimateLineItems_31E95BD977F9F2CB71585972FCE5A35E" xlink:to="loc_us-gaap_ConcentrationRiskPercentage1_CD3260AD6979465566905972FCE6B283" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_RevenuePerformanceObligationSalesRebatePaymentPeriod" xlink:label="loc_lly_RevenuePerformanceObligationSalesRebatePaymentPeriod_3293B0C47CADB06041325972FCE676B5" xlink:type="locator" />
    <link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ChangeInAccountingEstimateLineItems_31E95BD977F9F2CB71585972FCE5A35E" xlink:to="loc_lly_RevenuePerformanceObligationSalesRebatePaymentPeriod_3293B0C47CADB06041325972FCE676B5" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_RevenuePerformanceObligationSalesReturnsProductExpirationDate" xlink:label="loc_lly_RevenuePerformanceObligationSalesReturnsProductExpirationDate_4D1FFBCDDD3908B9C0F05972FCE6F42F" xlink:type="locator" />
    <link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ChangeInAccountingEstimateLineItems_31E95BD977F9F2CB71585972FCE5A35E" xlink:to="loc_lly_RevenuePerformanceObligationSalesReturnsProductExpirationDate_4D1FFBCDDD3908B9C0F05972FCE6F42F" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_RevenuePerformanceObligationSalesReturnsAverageInventoryLevel" xlink:label="loc_lly_RevenuePerformanceObligationSalesReturnsAverageInventoryLevel_EE94018C73678976258E5972FCE64409" xlink:type="locator" />
    <link:definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ChangeInAccountingEstimateLineItems_31E95BD977F9F2CB71585972FCE5A35E" xlink:to="loc_lly_RevenuePerformanceObligationSalesReturnsAverageInventoryLevel_EE94018C73678976258E5972FCE64409" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_RevenuePerformanceObligationSalesReturnsPercentageOfNetRevenue" xlink:label="loc_lly_RevenuePerformanceObligationSalesReturnsPercentageOfNetRevenue_B636C06E1CBE17C57E075972FCE6E57E" xlink:type="locator" />
    <link:definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ChangeInAccountingEstimateLineItems_31E95BD977F9F2CB71585972FCE5A35E" xlink:to="loc_lly_RevenuePerformanceObligationSalesReturnsPercentageOfNetRevenue_B636C06E1CBE17C57E075972FCE6E57E" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_RevenueInformationUsedToDetermineRevenueRecognizedChangeInAccountingEstimatePercent" xlink:label="loc_lly_RevenueInformationUsedToDetermineRevenueRecognizedChangeInAccountingEstimatePercent_DB7791763D398469F7575972FCE7EE73" xlink:type="locator" />
    <link:definitionArc order="9" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ChangeInAccountingEstimateLineItems_31E95BD977F9F2CB71585972FCE5A35E" xlink:to="loc_lly_RevenueInformationUsedToDetermineRevenueRecognizedChangeInAccountingEstimatePercent_DB7791763D398469F7575972FCE7EE73" xlink:type="arc" />
  </link:definitionLink>
  <link:definitionLink xlink:role="http://www.lilly.com/role/RevenueSummaryOfRevenueRecognizedDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DisaggregationOfRevenueLineItems" xlink:label="loc_us-gaap_DisaggregationOfRevenueLineItems_9E8D07C6A75BAD888D18AE57C819E681" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DisaggregationOfRevenueTable" xlink:label="loc_us-gaap_DisaggregationOfRevenueTable_9655CF54D52845D0537BAE57C8171956" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_9E8D07C6A75BAD888D18AE57C819E681" xlink:to="loc_us-gaap_DisaggregationOfRevenueTable_9655CF54D52845D0537BAE57C8171956" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_ProductOrServiceAxis" xlink:label="loc_srt_ProductOrServiceAxis_4F77E7FEE43A8B598080AE57C8177A54" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_9655CF54D52845D0537BAE57C8171956" xlink:to="loc_srt_ProductOrServiceAxis_4F77E7FEE43A8B598080AE57C8177A54" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_ProductsAndServicesDomain" xlink:label="loc_srt_ProductsAndServicesDomain_DD15B94473D129991DC0AE57C818419A_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ProductOrServiceAxis_4F77E7FEE43A8B598080AE57C8177A54" xlink:to="loc_srt_ProductsAndServicesDomain_DD15B94473D129991DC0AE57C818419A_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd#srt_ProductsAndServicesDomain" xlink:label="loc_srt_ProductsAndServicesDomain_DD15B94473D129991DC0AE57C818419A" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ProductOrServiceAxis_4F77E7FEE43A8B598080AE57C8177A54" xlink:to="loc_srt_ProductsAndServicesDomain_DD15B94473D129991DC0AE57C818419A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ProductMember" xlink:label="loc_us-gaap_ProductMember_7D354A98757BE1549E2AAE57C8185292" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_DD15B94473D129991DC0AE57C818419A" xlink:to="loc_us-gaap_ProductMember_7D354A98757BE1549E2AAE57C8185292" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_CollaborationandOtherRevenueMember" xlink:label="loc_lly_CollaborationandOtherRevenueMember_55883A10F8DEC6215DF0AE57C8181BD2" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_DD15B94473D129991DC0AE57C818419A" xlink:to="loc_lly_CollaborationandOtherRevenueMember_55883A10F8DEC6215DF0AE57C8181BD2" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RoyaltyMember" xlink:label="loc_us-gaap_RoyaltyMember_114BA85E037B85236C5AAE57C819ECDA" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_DD15B94473D129991DC0AE57C818419A" xlink:to="loc_us-gaap_RoyaltyMember_114BA85E037B85236C5AAE57C819ECDA" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_Revenues" xlink:label="loc_us-gaap_Revenues_AFB06C49A63D8432D550AE57C81902AA" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_9E8D07C6A75BAD888D18AE57C819E681" xlink:to="loc_us-gaap_Revenues_AFB06C49A63D8432D550AE57C81902AA" xlink:type="arc" />
  </link:definitionLink>
  <link:definitionLink xlink:role="http://www.lilly.com/role/RevenueTables" xlink:type="extended" />
  <link:definitionLink xlink:role="http://www.lilly.com/role/SelectedQuarterlyDataUnaudited" xlink:type="extended" />
  <link:definitionLink xlink:role="http://www.lilly.com/role/SelectedQuarterlyDataUnauditedDetails" xlink:type="extended" />
  <link:definitionLink xlink:role="http://www.lilly.com/role/SelectedQuarterlyDataUnauditedTables" xlink:type="extended" />
  <link:definitionLink xlink:role="http://www.lilly.com/role/ShareholdersEquity" xlink:type="extended" />
  <link:definitionLink xlink:role="http://www.lilly.com/role/ShareholdersEquityDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ClassOfStockLineItems" xlink:label="loc_us-gaap_ClassOfStockLineItems_6A14D1387C9330D925EB3BA23BE56838" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfStockByClassTable" xlink:label="loc_us-gaap_ScheduleOfStockByClassTable_A535D1127E9F997F046C3BA23BE480D5" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ClassOfStockLineItems_6A14D1387C9330D925EB3BA23BE56838" xlink:to="loc_us-gaap_ScheduleOfStockByClassTable_A535D1127E9F997F046C3BA23BE480D5" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareRepurchaseProgramAxis" xlink:label="loc_us-gaap_ShareRepurchaseProgramAxis_03C2133AD582CCDEB0893BA23BE4B4CD" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_A535D1127E9F997F046C3BA23BE480D5" xlink:to="loc_us-gaap_ShareRepurchaseProgramAxis_03C2133AD582CCDEB0893BA23BE4B4CD" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareRepurchaseProgramDomain" xlink:label="loc_us-gaap_ShareRepurchaseProgramDomain_0C3802E252305AB5EF193BA23BE5656E_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ShareRepurchaseProgramAxis_03C2133AD582CCDEB0893BA23BE4B4CD" xlink:to="loc_us-gaap_ShareRepurchaseProgramDomain_0C3802E252305AB5EF193BA23BE5656E_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareRepurchaseProgramDomain" xlink:label="loc_us-gaap_ShareRepurchaseProgramDomain_0C3802E252305AB5EF193BA23BE5656E" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ShareRepurchaseProgramAxis_03C2133AD582CCDEB0893BA23BE4B4CD" xlink:to="loc_us-gaap_ShareRepurchaseProgramDomain_0C3802E252305AB5EF193BA23BE5656E" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_A2018RepurchaseProgramMember" xlink:label="loc_lly_A2018RepurchaseProgramMember_F3F31ACA4DD3309469B63BA23BE58383" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareRepurchaseProgramDomain_0C3802E252305AB5EF193BA23BE5656E" xlink:to="loc_lly_A2018RepurchaseProgramMember_F3F31ACA4DD3309469B63BA23BE58383" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_TreasuryStockValueAcquiredCostMethod" xlink:label="loc_us-gaap_TreasuryStockValueAcquiredCostMethod_608928D9DB06477F46223BA23BE54E1E" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_6A14D1387C9330D925EB3BA23BE56838" xlink:to="loc_us-gaap_TreasuryStockValueAcquiredCostMethod_608928D9DB06477F46223BA23BE54E1E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StockRepurchaseProgramRemainingAuthorizedRepurchaseAmount1" xlink:label="loc_us-gaap_StockRepurchaseProgramRemainingAuthorizedRepurchaseAmount1_BEC5F3B7E03F867906053BA23BE63A8D" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_6A14D1387C9330D925EB3BA23BE56838" xlink:to="loc_us-gaap_StockRepurchaseProgramRemainingAuthorizedRepurchaseAmount1_BEC5F3B7E03F867906053BA23BE63A8D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StockRepurchaseProgramAuthorizedAmount1" xlink:label="loc_us-gaap_StockRepurchaseProgramAuthorizedAmount1_0A1FCC50DE56916EB7743BA23BE69E7B" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_6A14D1387C9330D925EB3BA23BE56838" xlink:to="loc_us-gaap_StockRepurchaseProgramAuthorizedAmount1_0A1FCC50DE56916EB7743BA23BE69E7B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PreferredStockSharesAuthorized" xlink:label="loc_us-gaap_PreferredStockSharesAuthorized_43CC0DF08C67CE8CC0453BA23BE6C9F9" xlink:type="locator" />
    <link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_6A14D1387C9330D925EB3BA23BE56838" xlink:to="loc_us-gaap_PreferredStockSharesAuthorized_43CC0DF08C67CE8CC0453BA23BE6C9F9" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PreferredStockSharesIssued" xlink:label="loc_us-gaap_PreferredStockSharesIssued_13A9B99E55E7E3D724CA3BA23BE6BF44" xlink:type="locator" />
    <link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_6A14D1387C9330D925EB3BA23BE56838" xlink:to="loc_us-gaap_PreferredStockSharesIssued_13A9B99E55E7E3D724CA3BA23BE6BF44" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CommonStockSharesHeldInEmployeeTrustShares" xlink:label="loc_us-gaap_CommonStockSharesHeldInEmployeeTrustShares_18F0CEA19B112864111D3BA23BE69641" xlink:type="locator" />
    <link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_6A14D1387C9330D925EB3BA23BE56838" xlink:to="loc_us-gaap_CommonStockSharesHeldInEmployeeTrustShares_18F0CEA19B112864111D3BA23BE69641" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CommonStockSharesHeldInEmployeeTrust" xlink:label="loc_us-gaap_CommonStockSharesHeldInEmployeeTrust_2E58D18678AEC3F3C4663BA23BE778AC" xlink:type="locator" />
    <link:definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_6A14D1387C9330D925EB3BA23BE56838" xlink:to="loc_us-gaap_CommonStockSharesHeldInEmployeeTrust_2E58D18678AEC3F3C4663BA23BE778AC" xlink:type="arc" />
  </link:definitionLink>
  <link:definitionLink xlink:role="http://www.lilly.com/role/StockBasedCompensation" xlink:type="extended" />
  <link:definitionLink xlink:role="http://www.lilly.com/role/StockBasedCompensationDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_44E2044670FC144F1D5EAE57C5D6F84C" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_519880AD983DF88BFF41AE57C5D4FA52" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_44E2044670FC144F1D5EAE57C5D6F84C" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_519880AD983DF88BFF41AE57C5D4FA52" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AwardTypeAxis" xlink:label="loc_us-gaap_AwardTypeAxis_E97BA5A45EB88DA2F752AE57C5D56C2D" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_519880AD983DF88BFF41AE57C5D4FA52" xlink:to="loc_us-gaap_AwardTypeAxis_E97BA5A45EB88DA2F752AE57C5D56C2D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_E069D340BAE2F5821E6AAE57C5D5AFD9_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AwardTypeAxis_E97BA5A45EB88DA2F752AE57C5D56C2D" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_E069D340BAE2F5821E6AAE57C5D5AFD9_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_E069D340BAE2F5821E6AAE57C5D5AFD9" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AwardTypeAxis_E97BA5A45EB88DA2F752AE57C5D56C2D" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_E069D340BAE2F5821E6AAE57C5D5AFD9" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PerformanceSharesMember" xlink:label="loc_us-gaap_PerformanceSharesMember_C733045CD4E38673C0E0AE57C5D542F8" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_E069D340BAE2F5821E6AAE57C5D5AFD9" xlink:to="loc_us-gaap_PerformanceSharesMember_C733045CD4E38673C0E0AE57C5D542F8" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_ShareholderValueAwardsMember" xlink:label="loc_lly_ShareholderValueAwardsMember_9E3A5D93493A0D91582BAE57C5D6DF35" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_E069D340BAE2F5821E6AAE57C5D5AFD9" xlink:to="loc_lly_ShareholderValueAwardsMember_9E3A5D93493A0D91582BAE57C5D6DF35" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RestrictedStockUnitsRSUMember" xlink:label="loc_us-gaap_RestrictedStockUnitsRSUMember_FA8F3F97DEA4E24767C6AE57C5D6C560" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_E069D340BAE2F5821E6AAE57C5D5AFD9" xlink:to="loc_us-gaap_RestrictedStockUnitsRSUMember_FA8F3F97DEA4E24767C6AE57C5D6C560" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant_642000BDEB54267CAC59AE57C5D78AF8" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_44E2044670FC144F1D5EAE57C5D6F84C" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant_642000BDEB54267CAC59AE57C5D78AF8" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1_7F63B2343E046CDB4098AE57C5D7A6A7" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_44E2044670FC144F1D5EAE57C5D6F84C" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1_7F63B2343E046CDB4098AE57C5D7A6A7" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_96DE2717655FADC9B84BAE57C5D72640" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_44E2044670FC144F1D5EAE57C5D6F84C" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_96DE2717655FADC9B84BAE57C5D72640" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesIssuedInPeriod" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesIssuedInPeriod_431716ABD6526F950E1EAE57C5D7B69B" xlink:type="locator" />
    <link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_44E2044670FC144F1D5EAE57C5D6F84C" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesIssuedInPeriod_431716ABD6526F950E1EAE57C5D7B69B" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_ShareBasedCompensationArrangementByShareBasedPaymentAwardExpectedSharesToBeIssued" xlink:label="loc_lly_ShareBasedCompensationArrangementByShareBasedPaymentAwardExpectedSharesToBeIssued_AAE397FC6FB109D77487AE57C5D79374" xlink:type="locator" />
    <link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_44E2044670FC144F1D5EAE57C5D6F84C" xlink:to="loc_lly_ShareBasedCompensationArrangementByShareBasedPaymentAwardExpectedSharesToBeIssued_AAE397FC6FB109D77487AE57C5D79374" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognized" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognized_AECED3E106446E6AAA87AE57C5D81C76" xlink:type="locator" />
    <link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_44E2044670FC144F1D5EAE57C5D6F84C" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognized_AECED3E106446E6AAA87AE57C5D81C76" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1_4921BCFD93C0A260C4F3AE57C5D82717" xlink:type="locator" />
    <link:definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_44E2044670FC144F1D5EAE57C5D6F84C" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1_4921BCFD93C0A260C4F3AE57C5D82717" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod_1D71B4B266E44F36003CAE57C5D88F17" xlink:type="locator" />
    <link:definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_44E2044670FC144F1D5EAE57C5D6F84C" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod_1D71B4B266E44F36003CAE57C5D88F17" xlink:type="arc" />
  </link:definitionLink>
  <link:definitionLink xlink:role="http://www.lilly.com/role/StockBasedCompensationPolicies" xlink:type="extended" />
  <link:definitionLink xlink:role="http://www.lilly.com/role/StockBasedCompensationScheduleOfAssumptionsUsedDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_45DAB28D11E1D8F9FE67AE8F36EDE64E" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_CD340200CF3E2EBF1EBEAE8F36D2CC5B" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_45DAB28D11E1D8F9FE67AE8F36EDE64E" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_CD340200CF3E2EBF1EBEAE8F36D2CC5B" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AwardTypeAxis" xlink:label="loc_us-gaap_AwardTypeAxis_A2F10D34DC3C1EA581E6AE8F36D271E6" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_CD340200CF3E2EBF1EBEAE8F36D2CC5B" xlink:to="loc_us-gaap_AwardTypeAxis_A2F10D34DC3C1EA581E6AE8F36D271E6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_D9414FAB2EA53502B341AE8F36D3F8E9_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AwardTypeAxis_A2F10D34DC3C1EA581E6AE8F36D271E6" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_D9414FAB2EA53502B341AE8F36D3F8E9_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_D9414FAB2EA53502B341AE8F36D3F8E9" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AwardTypeAxis_A2F10D34DC3C1EA581E6AE8F36D271E6" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_D9414FAB2EA53502B341AE8F36D3F8E9" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_ShareholderValueAwardsMember" xlink:label="loc_lly_ShareholderValueAwardsMember_B508F22386F1CD8225DFAE8F37B2EDA4" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_D9414FAB2EA53502B341AE8F36D3F8E9" xlink:to="loc_lly_ShareholderValueAwardsMember_B508F22386F1CD8225DFAE8F37B2EDA4" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate_58E8EE056E15459CD41BAE8F3729CD27" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_45DAB28D11E1D8F9FE67AE8F36EDE64E" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate_58E8EE056E15459CD41BAE8F3729CD27" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate_9A3C382A1EE10223EF5AAE8F374E3834" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_45DAB28D11E1D8F9FE67AE8F36EDE64E" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate_9A3C382A1EE10223EF5AAE8F374E3834" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate_80B59EF773D4B7067EBCAE8F377CD054" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_45DAB28D11E1D8F9FE67AE8F36EDE64E" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate_80B59EF773D4B7067EBCAE8F377CD054" xlink:type="arc" />
  </link:definitionLink>
  <link:definitionLink xlink:role="http://www.lilly.com/role/StockBasedCompensationScheduleOfStockBasedCompensationExpenseDetails" xlink:type="extended" />
  <link:definitionLink xlink:role="http://www.lilly.com/role/StockBasedCompensationTables" xlink:type="extended" />
  <link:definitionLink xlink:role="http://www.lilly.com/role/SummaryOfSignificantAccountingPoliciesAndImplementationOfNewFinancialAccountingPronouncementsPolicies" xlink:type="extended" />
  <link:definitionLink xlink:role="http://www.lilly.com/role/SummaryOfSignificantAccountingPoliciesAndImplementationOfNewFinancialAccountingStandards" xlink:type="extended" />
  <link:definitionLink xlink:role="http://www.lilly.com/role/SummaryOfSignificantAccountingPoliciesAndImplementationOfNewFinancialAccountingStandardsNarrativeDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems" xlink:label="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_3C7FB7F5BE7DEDF2B04836C0ED3ED4B5" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsTable" xlink:label="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsTable_D67EA244347977F8F68636C0ED3A0996" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_3C7FB7F5BE7DEDF2B04836C0ED3ED4B5" xlink:to="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsTable_D67EA244347977F8F68636C0ED3A0996" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AdjustmentsForNewAccountingPronouncementsAxis" xlink:label="loc_us-gaap_AdjustmentsForNewAccountingPronouncementsAxis_3CBC71B9A9E675E8C8FF36C0ED3B669A" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsTable_D67EA244347977F8F68636C0ED3A0996" xlink:to="loc_us-gaap_AdjustmentsForNewAccountingPronouncementsAxis_3CBC71B9A9E675E8C8FF36C0ED3B669A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_TypeOfAdoptionMember" xlink:label="loc_us-gaap_TypeOfAdoptionMember_F32546FF339F73A5147836C0ED3B47C1_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AdjustmentsForNewAccountingPronouncementsAxis_3CBC71B9A9E675E8C8FF36C0ED3B669A" xlink:to="loc_us-gaap_TypeOfAdoptionMember_F32546FF339F73A5147836C0ED3B47C1_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_TypeOfAdoptionMember" xlink:label="loc_us-gaap_TypeOfAdoptionMember_F32546FF339F73A5147836C0ED3B47C1" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AdjustmentsForNewAccountingPronouncementsAxis_3CBC71B9A9E675E8C8FF36C0ED3B669A" xlink:to="loc_us-gaap_TypeOfAdoptionMember_F32546FF339F73A5147836C0ED3B47C1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AccountingStandardsUpdate201602Member" xlink:label="loc_us-gaap_AccountingStandardsUpdate201602Member_540E335AFFBEBFEE06F336C0ED3B709A" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TypeOfAdoptionMember_F32546FF339F73A5147836C0ED3B47C1" xlink:to="loc_us-gaap_AccountingStandardsUpdate201602Member_540E335AFFBEBFEE06F336C0ED3B709A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AccountingStandardsUpdate201409Member" xlink:label="loc_us-gaap_AccountingStandardsUpdate201409Member_DFD17C8327736364B5C936C0ED3C2008" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TypeOfAdoptionMember_F32546FF339F73A5147836C0ED3B47C1" xlink:to="loc_us-gaap_AccountingStandardsUpdate201409Member_DFD17C8327736364B5C936C0ED3C2008" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AccountingStandardsUpdate201601Member" xlink:label="loc_us-gaap_AccountingStandardsUpdate201601Member_5FA655E3002DBFFC0AEF36C0ED3C50ED" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TypeOfAdoptionMember_F32546FF339F73A5147836C0ED3B47C1" xlink:to="loc_us-gaap_AccountingStandardsUpdate201601Member_5FA655E3002DBFFC0AEF36C0ED3C50ED" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AccountingStandardsUpdate201616Member" xlink:label="loc_us-gaap_AccountingStandardsUpdate201616Member_FEA4D50CDF05E4F0BF3D36C0ED3CE190" xlink:type="locator" />
    <link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TypeOfAdoptionMember_F32546FF339F73A5147836C0ED3B47C1" xlink:to="loc_us-gaap_AccountingStandardsUpdate201616Member_FEA4D50CDF05E4F0BF3D36C0ED3CE190" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AccountingStandardsUpdate201802Member" xlink:label="loc_us-gaap_AccountingStandardsUpdate201802Member_E1C35C0A87CEC1685FAF36C0ED3C3858" xlink:type="locator" />
    <link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TypeOfAdoptionMember_F32546FF339F73A5147836C0ED3B47C1" xlink:to="loc_us-gaap_AccountingStandardsUpdate201802Member_E1C35C0A87CEC1685FAF36C0ED3C3858" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DisposalGroupClassificationAxis" xlink:label="loc_us-gaap_DisposalGroupClassificationAxis_4C8F14E69AB0D904236236C0ED3CDC24" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsTable_D67EA244347977F8F68636C0ED3A0996" xlink:to="loc_us-gaap_DisposalGroupClassificationAxis_4C8F14E69AB0D904236236C0ED3CDC24" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DisposalGroupClassificationDomain" xlink:label="loc_us-gaap_DisposalGroupClassificationDomain_D199B6DAB602D8E1E40636C0ED3C2D4B_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DisposalGroupClassificationAxis_4C8F14E69AB0D904236236C0ED3CDC24" xlink:to="loc_us-gaap_DisposalGroupClassificationDomain_D199B6DAB602D8E1E40636C0ED3C2D4B_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DisposalGroupClassificationDomain" xlink:label="loc_us-gaap_DisposalGroupClassificationDomain_D199B6DAB602D8E1E40636C0ED3C2D4B" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DisposalGroupClassificationAxis_4C8F14E69AB0D904236236C0ED3CDC24" xlink:to="loc_us-gaap_DisposalGroupClassificationDomain_D199B6DAB602D8E1E40636C0ED3C2D4B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DiscontinuedOperationsDisposedOfBySaleMember" xlink:label="loc_us-gaap_DiscontinuedOperationsDisposedOfBySaleMember_83C7BA66F6DB50BB002036C0ED3DF5DA" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DisposalGroupClassificationDomain_D199B6DAB602D8E1E40636C0ED3C2D4B" xlink:to="loc_us-gaap_DiscontinuedOperationsDisposedOfBySaleMember_83C7BA66F6DB50BB002036C0ED3DF5DA" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis" xlink:label="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis_4F20F4BE0F3A6B4C5F1E36C0ED3D0303" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsTable_D67EA244347977F8F68636C0ED3A0996" xlink:to="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis_4F20F4BE0F3A6B4C5F1E36C0ED3D0303" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain" xlink:label="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_47E7E47A773B6D19798E36C0ED3D99E9_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis_4F20F4BE0F3A6B4C5F1E36C0ED3D0303" xlink:to="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_47E7E47A773B6D19798E36C0ED3D99E9_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain" xlink:label="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_47E7E47A773B6D19798E36C0ED3D99E9" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis_4F20F4BE0F3A6B4C5F1E36C0ED3D0303" xlink:to="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_47E7E47A773B6D19798E36C0ED3D99E9" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_ElancoAnimalHealthIncorporatedMember" xlink:label="loc_lly_ElancoAnimalHealthIncorporatedMember_21DC74192FCAB1B9708036C0ED3D8FFE" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_47E7E47A773B6D19798E36C0ED3D99E9" xlink:to="loc_lly_ElancoAnimalHealthIncorporatedMember_21DC74192FCAB1B9708036C0ED3D8FFE" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_MinorityInterestOwnershipPercentageByParent" xlink:label="loc_us-gaap_MinorityInterestOwnershipPercentageByParent_2872D5ADD2024D5092EC36C0ED3EB646" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_3C7FB7F5BE7DEDF2B04836C0ED3ED4B5" xlink:to="loc_us-gaap_MinorityInterestOwnershipPercentageByParent_2872D5ADD2024D5092EC36C0ED3EB646" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AdvertisingExpense" xlink:label="loc_us-gaap_AdvertisingExpense_70D649D42014E74C046936C0ED3E18CB" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_3C7FB7F5BE7DEDF2B04836C0ED3ED4B5" xlink:to="loc_us-gaap_AdvertisingExpense_70D649D42014E74C046936C0ED3E18CB" xlink:type="arc" />
    <link:loc xlink:href="lly-20191231.xsd#lly_AdvertisingExpensePercentageOfRevenue" xlink:label="loc_lly_AdvertisingExpensePercentageOfRevenue_6A015CD841CE64691E8036C0ED3EE536" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_3C7FB7F5BE7DEDF2B04836C0ED3ED4B5" xlink:to="loc_lly_AdvertisingExpensePercentageOfRevenue_6A015CD841CE64691E8036C0ED3EE536" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OperatingLeaseRightOfUseAsset" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAsset_0167BB548753EDD08E6036C0ED3E6023" xlink:type="locator" />
    <link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_3C7FB7F5BE7DEDF2B04836C0ED3ED4B5" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAsset_0167BB548753EDD08E6036C0ED3E6023" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ContractWithCustomerLiability" xlink:label="loc_us-gaap_ContractWithCustomerLiability_D3F7533AB79AEFBFA2B536C0ED3FA9F9" xlink:type="locator" />
    <link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_3C7FB7F5BE7DEDF2B04836C0ED3ED4B5" xlink:to="loc_us-gaap_ContractWithCustomerLiability_D3F7533AB79AEFBFA2B536C0ED3FA9F9" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OperatingLeaseLiability" xlink:label="loc_us-gaap_OperatingLeaseLiability_06616493277E801692FD36C0ED3F4C75" xlink:type="locator" />
    <link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_3C7FB7F5BE7DEDF2B04836C0ED3ED4B5" xlink:to="loc_us-gaap_OperatingLeaseLiability_06616493277E801692FD36C0ED3F4C75" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RetainedEarningsAccumulatedDeficit" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_39292F0AB6D3ED38B0D936C0ED3F247C" xlink:type="locator" />
    <link:definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_3C7FB7F5BE7DEDF2B04836C0ED3ED4B5" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_39292F0AB6D3ED38B0D936C0ED3F247C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_0EEFE759265233B783F936C0ED3F7451" xlink:type="locator" />
    <link:definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_3C7FB7F5BE7DEDF2B04836C0ED3ED4B5" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_0EEFE759265233B783F936C0ED3F7451" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DeferredTaxAssetsLiabilitiesNet" xlink:label="loc_us-gaap_DeferredTaxAssetsLiabilitiesNet_D2D69674FB36F676874136C0ED3F207A" xlink:type="locator" />
    <link:definitionArc order="9" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_3C7FB7F5BE7DEDF2B04836C0ED3ED4B5" xlink:to="loc_us-gaap_DeferredTaxAssetsLiabilitiesNet_D2D69674FB36F676874136C0ED3F207A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DeferredTaxLiabilities" xlink:label="loc_us-gaap_DeferredTaxLiabilities_068DBFFEE5F7DE71E19136C0ED44BAA4" xlink:type="locator" />
    <link:definitionArc order="10" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_3C7FB7F5BE7DEDF2B04836C0ED3ED4B5" xlink:to="loc_us-gaap_DeferredTaxLiabilities_068DBFFEE5F7DE71E19136C0ED44BAA4" xlink:type="arc" />
  </link:definitionLink>
</link:linkbase>
