<?xml version="1.0" encoding="US-ASCII"?>
<!--XBRL Document Created with Wdesk from Workiva-->
<!-- -->
<linkbase xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd" xmlns="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
  <roleRef roleURI="http://www.lilly.com/role/Acquisitions" xlink:href="lly-20151231.xsd#Acquisitions" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/AcquisitionsAcquisitionsPolicies" xlink:href="lly-20151231.xsd#AcquisitionsAcquisitionsPolicies" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/AcquisitionsAcquisitionsTables" xlink:href="lly-20151231.xsd#AcquisitionsAcquisitionsTables" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/AcquisitionsDetails" xlink:href="lly-20151231.xsd#AcquisitionsDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/AssetImpairmentsRestructuringAndOtherSpecialCharges" xlink:href="lly-20151231.xsd#AssetImpairmentsRestructuringAndOtherSpecialCharges" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/AssetImpairmentsRestructuringAndOtherSpecialChargesDetails" xlink:href="lly-20151231.xsd#AssetImpairmentsRestructuringAndOtherSpecialChargesDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/AssetImpairmentsRestructuringAndOtherSpecialChargesTables" xlink:href="lly-20151231.xsd#AssetImpairmentsRestructuringAndOtherSpecialChargesTables" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/Borrowings" xlink:href="lly-20151231.xsd#Borrowings" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/BorrowingsDetails" xlink:href="lly-20151231.xsd#BorrowingsDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/BorrowingsTables" xlink:href="lly-20151231.xsd#BorrowingsTables" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/Collaborations" xlink:href="lly-20151231.xsd#Collaborations" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/CollaborationsDetails" xlink:href="lly-20151231.xsd#CollaborationsDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/CollaborationsTables" xlink:href="lly-20151231.xsd#CollaborationsTables" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/ConsolidatedBalanceSheets" xlink:href="lly-20151231.xsd#ConsolidatedBalanceSheets" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/ConsolidatedBalanceSheetsParenthetical" xlink:href="lly-20151231.xsd#ConsolidatedBalanceSheetsParenthetical" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/ConsolidatedStatementsOfCashFlows" xlink:href="lly-20151231.xsd#ConsolidatedStatementsOfCashFlows" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/ConsolidatedStatementsOfComprehensiveIncomeLoss" xlink:href="lly-20151231.xsd#ConsolidatedStatementsOfComprehensiveIncomeLoss" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/ConsolidatedStatementsOfOperations" xlink:href="lly-20151231.xsd#ConsolidatedStatementsOfOperations" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/ConsolidatedStatementsOfShareholdersEquityStatement" xlink:href="lly-20151231.xsd#ConsolidatedStatementsOfShareholdersEquityStatement" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/Contingencies" xlink:href="lly-20151231.xsd#Contingencies" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/ContingenciesContingenciesPolicies" xlink:href="lly-20151231.xsd#ContingenciesContingenciesPolicies" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/ContingenciesDetails" xlink:href="lly-20151231.xsd#ContingenciesDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/DocumentAndEntityInformation" xlink:href="lly-20151231.xsd#DocumentAndEntityInformation" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/EarningsLossPerShareDetails" xlink:href="lly-20151231.xsd#EarningsLossPerShareDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/EarningsLossPerShareTables" xlink:href="lly-20151231.xsd#EarningsLossPerShareTables" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/EarningsPerShare" xlink:href="lly-20151231.xsd#EarningsPerShare" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/FinancialInstruments" xlink:href="lly-20151231.xsd#FinancialInstruments" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/FinancialInstrumentsDetails" xlink:href="lly-20151231.xsd#FinancialInstrumentsDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/FinancialInstrumentsPolicies" xlink:href="lly-20151231.xsd#FinancialInstrumentsPolicies" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/FinancialInstrumentsTables" xlink:href="lly-20151231.xsd#FinancialInstrumentsTables" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/GoodwillAndOtherIntangibles" xlink:href="lly-20151231.xsd#GoodwillAndOtherIntangibles" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/GoodwillAndOtherIntangiblesDetails" xlink:href="lly-20151231.xsd#GoodwillAndOtherIntangiblesDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/GoodwillAndOtherIntangiblesGoodwillAndOtherIntangiblesPolicies" xlink:href="lly-20151231.xsd#GoodwillAndOtherIntangiblesGoodwillAndOtherIntangiblesPolicies" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/GoodwillAndOtherIntangiblesTables" xlink:href="lly-20151231.xsd#GoodwillAndOtherIntangiblesTables" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/ImplementationOfNewFinancialAccountingPronouncements" xlink:href="lly-20151231.xsd#ImplementationOfNewFinancialAccountingPronouncements" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/ImplementationOfNewFinancialAccountingPronouncementsDetails" xlink:href="lly-20151231.xsd#ImplementationOfNewFinancialAccountingPronouncementsDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/ImplementationOfNewFinancialAccountingPronouncementsImplementationOfNewFinancialAccountingPronouncementsTables" xlink:href="lly-20151231.xsd#ImplementationOfNewFinancialAccountingPronouncementsImplementationOfNewFinancialAccountingPronouncementsTables" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/IncomeTaxes" xlink:href="lly-20151231.xsd#IncomeTaxes" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/IncomeTaxesCompositionAndDeferredsDetails" xlink:href="lly-20151231.xsd#IncomeTaxesCompositionAndDeferredsDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/IncomeTaxesIncomeTaxExpenseAndUnrecognizedTaxBenefitsDetails" xlink:href="lly-20151231.xsd#IncomeTaxesIncomeTaxExpenseAndUnrecognizedTaxBenefitsDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/IncomeTaxesIncomeTaxesPolicies" xlink:href="lly-20151231.xsd#IncomeTaxesIncomeTaxesPolicies" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/IncomeTaxesTables" xlink:href="lly-20151231.xsd#IncomeTaxesTables" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/InventoriesDetails" xlink:href="lly-20151231.xsd#InventoriesDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/InventoriesInventoriesPoliciesPolicies" xlink:href="lly-20151231.xsd#InventoriesInventoriesPoliciesPolicies" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/InventoriesNotes" xlink:href="lly-20151231.xsd#InventoriesNotes" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/InventoriesTables" xlink:href="lly-20151231.xsd#InventoriesTables" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/OtherComprehensiveIncomeLoss" xlink:href="lly-20151231.xsd#OtherComprehensiveIncomeLoss" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/OtherComprehensiveIncomeLossDetails" xlink:href="lly-20151231.xsd#OtherComprehensiveIncomeLossDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/OtherComprehensiveIncomeLossTables" xlink:href="lly-20151231.xsd#OtherComprehensiveIncomeLossTables" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/OtherNetExpenseIncome" xlink:href="lly-20151231.xsd#OtherNetExpenseIncome" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/OtherNetExpenseIncomeDetails" xlink:href="lly-20151231.xsd#OtherNetExpenseIncomeDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/OtherNetExpenseIncomeTables" xlink:href="lly-20151231.xsd#OtherNetExpenseIncomeTables" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/PropertyAndEquipmentDetails" xlink:href="lly-20151231.xsd#PropertyAndEquipmentDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/PropertyAndEquipmentNotes" xlink:href="lly-20151231.xsd#PropertyAndEquipmentNotes" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/PropertyAndEquipmentPropertyAndEquipmentPolicies" xlink:href="lly-20151231.xsd#PropertyAndEquipmentPropertyAndEquipmentPolicies" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/PropertyAndEquipmentTables" xlink:href="lly-20151231.xsd#PropertyAndEquipmentTables" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/RetirementBenefits" xlink:href="lly-20151231.xsd#RetirementBenefits" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/RetirementBenefitsFairValueDisclosuresDetails" xlink:href="lly-20151231.xsd#RetirementBenefitsFairValueDisclosuresDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/RetirementBenefitsScheduleOfBenefitObligationsAndPlanAssetsDetails" xlink:href="lly-20151231.xsd#RetirementBenefitsScheduleOfBenefitObligationsAndPlanAssetsDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/RetirementBenefitsScheduleOfComponentsInConsolidatedBalanceSheetsDetails" xlink:href="lly-20151231.xsd#RetirementBenefitsScheduleOfComponentsInConsolidatedBalanceSheetsDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/RetirementBenefitsScheduleOfExpectedBenefitPaymentsContributionsAndExpenseDetails" xlink:href="lly-20151231.xsd#RetirementBenefitsScheduleOfExpectedBenefitPaymentsContributionsAndExpenseDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/RetirementBenefitsScheduleOfWeightedAverageAssumptionsDetails" xlink:href="lly-20151231.xsd#RetirementBenefitsScheduleOfWeightedAverageAssumptionsDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/RetirementBenefitsTables" xlink:href="lly-20151231.xsd#RetirementBenefitsTables" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/SegmentInformation" xlink:href="lly-20151231.xsd#SegmentInformation" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/SegmentInformationSegmentInformationDetails" xlink:href="lly-20151231.xsd#SegmentInformationSegmentInformationDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/SegmentInformationSegmentInformationTables" xlink:href="lly-20151231.xsd#SegmentInformationSegmentInformationTables" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/SelectedQuarterlyDataDetails" xlink:href="lly-20151231.xsd#SelectedQuarterlyDataDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/SelectedQuarterlyDataNotes" xlink:href="lly-20151231.xsd#SelectedQuarterlyDataNotes" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/SelectedQuarterlyDataTables" xlink:href="lly-20151231.xsd#SelectedQuarterlyDataTables" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/ShareholdersEquity" xlink:href="lly-20151231.xsd#ShareholdersEquity" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/ShareholdersEquityDetails" xlink:href="lly-20151231.xsd#ShareholdersEquityDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/ShareholdersEquityTables" xlink:href="lly-20151231.xsd#ShareholdersEquityTables" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/StockBasedCompensation" xlink:href="lly-20151231.xsd#StockBasedCompensation" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/StockBasedCompensationDetails" xlink:href="lly-20151231.xsd#StockBasedCompensationDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/StockBasedCompensationStockBasedCompensationPolicies" xlink:href="lly-20151231.xsd#StockBasedCompensationStockBasedCompensationPolicies" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/StockBasedCompensationTables" xlink:href="lly-20151231.xsd#StockBasedCompensationTables" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/SummaryOfSignificantAccountingPolicies" xlink:href="lly-20151231.xsd#SummaryOfSignificantAccountingPolicies" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/SummaryOfSignificantAccountingPoliciesDetails" xlink:href="lly-20151231.xsd#SummaryOfSignificantAccountingPoliciesDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/SummaryOfSignificantAccountingPoliciesPolicies" xlink:href="lly-20151231.xsd#SummaryOfSignificantAccountingPoliciesPolicies" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/SummaryOfSignificantAccountingPoliciesTables" xlink:href="lly-20151231.xsd#SummaryOfSignificantAccountingPoliciesTables" xlink:type="simple" />
  <roleRef roleURI="http://www.xbrl.org/2009/role/negatedLabel" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedLabel" xlink:type="simple" />
  <roleRef roleURI="http://www.xbrl.org/2009/role/negatedNetLabel" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedNetLabel" xlink:type="simple" />
  <roleRef roleURI="http://www.xbrl.org/2009/role/negatedPeriodEndLabel" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedPeriodEndLabel" xlink:type="simple" />
  <roleRef roleURI="http://www.xbrl.org/2009/role/negatedPeriodStartLabel" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedPeriodStartLabel" xlink:type="simple" />
  <roleRef roleURI="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedTerseLabel" xlink:type="simple" />
  <roleRef roleURI="http://www.xbrl.org/2009/role/negatedTotalLabel" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedTotalLabel" xlink:type="simple" />
  <roleRef roleURI="http://www.xbrl.org/2009/role/netLabel" xlink:href="http://www.xbrl.org/lrr/role/net-2009-12-16.xsd#netLabel" xlink:type="simple" />
  <presentationLink xlink:role="http://www.lilly.com/role/Acquisitions" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_BusinessCombinationsAbstract" xlink:label="loc_us-gaap_BusinessCombinationsAbstract_CBFF2DF5969D6903E13DFC036F15F6F2" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_MergersAcquisitionsAndDispositionsDisclosuresTextBlock" xlink:label="loc_us-gaap_MergersAcquisitionsAndDispositionsDisclosuresTextBlock_BCB8563FF95DCEABF0FDFC036F15C470" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessCombinationsAbstract_CBFF2DF5969D6903E13DFC036F15F6F2" xlink:to="loc_us-gaap_MergersAcquisitionsAndDispositionsDisclosuresTextBlock_BCB8563FF95DCEABF0FDFC036F15C470" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.lilly.com/role/AcquisitionsAcquisitionsPolicies" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_BusinessCombinationsAbstract" xlink:label="loc_us-gaap_BusinessCombinationsAbstract_EE70339ED88F70179F86F6980218595B" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_BusinessCombinationsPolicy" xlink:label="loc_us-gaap_BusinessCombinationsPolicy_D0F1D6A0B8770E98CCF9F5374AD8DD9F" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessCombinationsAbstract_EE70339ED88F70179F86F6980218595B" xlink:to="loc_us-gaap_BusinessCombinationsPolicy_D0F1D6A0B8770E98CCF9F5374AD8DD9F" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.lilly.com/role/AcquisitionsAcquisitionsTables" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_BusinessCombinationsAbstract" xlink:label="loc_us-gaap_BusinessCombinationsAbstract_B5B29A97EFAD94D702AED0F7190B0E44" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable" xlink:label="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_000E2156055CA4B4BF7FD0F7190B84B0" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessCombinationsAbstract_B5B29A97EFAD94D702AED0F7190B0E44" xlink:to="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_000E2156055CA4B4BF7FD0F7190B84B0" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_BusinessAcquisitionAxis" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_73F3D457F986152BFA86D0F7190B5E4D" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_000E2156055CA4B4BF7FD0F7190B84B0" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_73F3D457F986152BFA86D0F7190B5E4D" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_FB5089F7F2980A568E14D0F7190CBCCD" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_73F3D457F986152BFA86D0F7190B5E4D" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_FB5089F7F2980A568E14D0F7190CBCCD" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_NovartisAnimalHealthMember" xlink:label="loc_lly_NovartisAnimalHealthMember_93A59E7E791AACDD634AD0F7190CAE71" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_FB5089F7F2980A568E14D0F7190CBCCD" xlink:to="loc_lly_NovartisAnimalHealthMember_93A59E7E791AACDD634AD0F7190CAE71" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_LohmannAnimalHealthMember" xlink:label="loc_lly_LohmannAnimalHealthMember_E0527D72B785E0D9409AD0F7190C4104" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_FB5089F7F2980A568E14D0F7190CBCCD" xlink:to="loc_lly_LohmannAnimalHealthMember_E0527D72B785E0D9409AD0F7190C4104" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_IncomeStatementLocationAxis" xlink:label="loc_us-gaap_IncomeStatementLocationAxis_A9B2190FBF1C47B013E8D0F7190C932B" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_000E2156055CA4B4BF7FD0F7190B84B0" xlink:to="loc_us-gaap_IncomeStatementLocationAxis_A9B2190FBF1C47B013E8D0F7190C932B" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_IncomeStatementLocationDomain" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_7DFBB31141B87B715A3DD0F7190C1DA8" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_A9B2190FBF1C47B013E8D0F7190C932B" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_7DFBB31141B87B715A3DD0F7190C1DA8" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StatementClassOfStockAxis" xlink:label="loc_us-gaap_StatementClassOfStockAxis_AF7B4B4F4D4D6E04B070D0F7190C0742" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_000E2156055CA4B4BF7FD0F7190B84B0" xlink:to="loc_us-gaap_StatementClassOfStockAxis_AF7B4B4F4D4D6E04B070D0F7190C0742" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ClassOfStockDomain" xlink:label="loc_us-gaap_ClassOfStockDomain_2C50B44983182591750DD0F7190C3935" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementClassOfStockAxis_AF7B4B4F4D4D6E04B070D0F7190C0742" xlink:to="loc_us-gaap_ClassOfStockDomain_2C50B44983182591750DD0F7190C3935" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_BusinessAcquisitionLineItems" xlink:label="loc_us-gaap_BusinessAcquisitionLineItems_BD4527B303E45860F05AD0F7190CDBD1" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_000E2156055CA4B4BF7FD0F7190B84B0" xlink:to="loc_us-gaap_BusinessAcquisitionLineItems_BD4527B303E45860F05AD0F7190CDBD1" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScheduleOfRecognizedIdentifiedAssetsAcquiredAndLiabilitiesAssumedTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfRecognizedIdentifiedAssetsAcquiredAndLiabilitiesAssumedTableTextBlock_D3E457FA85BF40FCFC45D0F7190C42EB" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_BD4527B303E45860F05AD0F7190CDBD1" xlink:to="loc_us-gaap_ScheduleOfRecognizedIdentifiedAssetsAcquiredAndLiabilitiesAssumedTableTextBlock_D3E457FA85BF40FCFC45D0F7190C42EB" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_BusinessAcquisitionProFormaInformationTextBlock" xlink:label="loc_us-gaap_BusinessAcquisitionProFormaInformationTextBlock_122CE2DDAA05FF06FF49D0F7190CF3D1" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_BD4527B303E45860F05AD0F7190CDBD1" xlink:to="loc_us-gaap_BusinessAcquisitionProFormaInformationTextBlock_122CE2DDAA05FF06FF49D0F7190CF3D1" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScheduleOfResearchAndDevelopmentAssetsAcquiredOtherThanThroughBusinessCombinationTextBlock" xlink:label="loc_us-gaap_ScheduleOfResearchAndDevelopmentAssetsAcquiredOtherThanThroughBusinessCombinationTextBlock_E4A0729C1A52FC783F07D0F7190CF756" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_BD4527B303E45860F05AD0F7190CDBD1" xlink:to="loc_us-gaap_ScheduleOfResearchAndDevelopmentAssetsAcquiredOtherThanThroughBusinessCombinationTextBlock_E4A0729C1A52FC783F07D0F7190CF756" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.lilly.com/role/AcquisitionsDetails" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_BusinessCombinationsAbstract" xlink:label="loc_us-gaap_BusinessCombinationsAbstract_448782EF37876E307011F535B583883F" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable" xlink:label="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_57921B5B6CC73650CB0FF535B5830055" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessCombinationsAbstract_448782EF37876E307011F535B583883F" xlink:to="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_57921B5B6CC73650CB0FF535B5830055" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_NonrecurringAdjustmentAxis" xlink:label="loc_us-gaap_NonrecurringAdjustmentAxis_4CE1A4087E8E61741F60F535B583A7BF" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_57921B5B6CC73650CB0FF535B5830055" xlink:to="loc_us-gaap_NonrecurringAdjustmentAxis_4CE1A4087E8E61741F60F535B583A7BF" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_NonrecurringAdjustmentDomain" xlink:label="loc_us-gaap_NonrecurringAdjustmentDomain_E7AEAB6F80A899E54976F535B5835E39" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NonrecurringAdjustmentAxis_4CE1A4087E8E61741F60F535B583A7BF" xlink:to="loc_us-gaap_NonrecurringAdjustmentDomain_E7AEAB6F80A899E54976F535B5835E39" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AcquisitionRelatedCostsMember" xlink:label="loc_us-gaap_AcquisitionRelatedCostsMember_C2C9C81BD856C339517DF535B5830B2C" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NonrecurringAdjustmentDomain_E7AEAB6F80A899E54976F535B5835E39" xlink:to="loc_us-gaap_AcquisitionRelatedCostsMember_C2C9C81BD856C339517DF535B5830B2C" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FairValueAdjustmentToInventoryMember" xlink:label="loc_us-gaap_FairValueAdjustmentToInventoryMember_A4EB07B2122319A291D4F535B583221E" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NonrecurringAdjustmentDomain_E7AEAB6F80A899E54976F535B5835E39" xlink:to="loc_us-gaap_FairValueAdjustmentToInventoryMember_A4EB07B2122319A291D4F535B583221E" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_AmortizationofFairValueAdjustedIntangibleAssetsMember" xlink:label="loc_lly_AmortizationofFairValueAdjustedIntangibleAssetsMember_A19B0A9AF8A7CEE89082F535B583A94E" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NonrecurringAdjustmentDomain_E7AEAB6F80A899E54976F535B5835E39" xlink:to="loc_lly_AmortizationofFairValueAdjustedIntangibleAssetsMember_A19B0A9AF8A7CEE89082F535B583A94E" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StatementGeographicalAxis" xlink:label="loc_us-gaap_StatementGeographicalAxis_F5641ECFEBC554CC8C1AF535B5833236" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_57921B5B6CC73650CB0FF535B5830055" xlink:to="loc_us-gaap_StatementGeographicalAxis_F5641ECFEBC554CC8C1AF535B5833236" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_SegmentGeographicalDomain" xlink:label="loc_us-gaap_SegmentGeographicalDomain_9BFD381F69D411735E00F535B583DE6F" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementGeographicalAxis_F5641ECFEBC554CC8C1AF535B5833236" xlink:to="loc_us-gaap_SegmentGeographicalDomain_9BFD381F69D411735E00F535B583DE6F" xlink:type="arc" />
    <loc xlink:href="http://xbrl.sec.gov/country/2013/country-2013-01-31.xsd#country_US" xlink:label="loc_country_US_160F76C63E744DF8454FF535B5831304" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentGeographicalDomain_9BFD381F69D411735E00F535B583DE6F" xlink:to="loc_country_US_160F76C63E744DF8454FF535B5831304" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ProductOrServiceAxis" xlink:label="loc_us-gaap_ProductOrServiceAxis_66F6C0335FE5355D5EE1F535B583D3F1" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_57921B5B6CC73650CB0FF535B5830055" xlink:to="loc_us-gaap_ProductOrServiceAxis_66F6C0335FE5355D5EE1F535B583D3F1" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ProductsAndServicesDomain" xlink:label="loc_us-gaap_ProductsAndServicesDomain_E3F072033218BF648933F535B5836A10" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ProductOrServiceAxis_66F6C0335FE5355D5EE1F535B583D3F1" xlink:to="loc_us-gaap_ProductsAndServicesDomain_E3F072033218BF648933F535B5836A10" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_TanezumabMember" xlink:label="loc_lly_TanezumabMember_24478D453E9F640A8FC1F535B5835376" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ProductsAndServicesDomain_E3F072033218BF648933F535B5836A10" xlink:to="loc_lly_TanezumabMember_24478D453E9F640A8FC1F535B5835376" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_U.S.SentinelProductLineMember" xlink:label="loc_lly_U.S.SentinelProductLineMember_9579BE15E3750274278AF535B583C655" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ProductsAndServicesDomain_E3F072033218BF648933F535B5836A10" xlink:to="loc_lly_U.S.SentinelProductLineMember_9579BE15E3750274278AF535B583C655" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_E528B52837AA839A1BFCF535B58357B0" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_57921B5B6CC73650CB0FF535B5830055" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_E528B52837AA839A1BFCF535B58357B0" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_FE33C359645BB6F369F1F535B583D697" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_E528B52837AA839A1BFCF535B58357B0" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_FE33C359645BB6F369F1F535B583D697" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DevelopedTechnologyRightsMember" xlink:label="loc_us-gaap_DevelopedTechnologyRightsMember_5311DE8BB8DF789B8B02F535B5831560" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_FE33C359645BB6F369F1F535B583D697" xlink:to="loc_us-gaap_DevelopedTechnologyRightsMember_5311DE8BB8DF789B8B02F535B5831560" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_BusinessAcquisitionAxis" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_D1C1BAF802CC8DCEBAA1F535B5835A5B" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_57921B5B6CC73650CB0FF535B5830055" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_D1C1BAF802CC8DCEBAA1F535B5835A5B" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_EB1CFDD6ACD6FA38548AF535B58392AB" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_D1C1BAF802CC8DCEBAA1F535B5835A5B" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_EB1CFDD6ACD6FA38548AF535B58392AB" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_InnoventBiologicsInc.Member" xlink:label="loc_lly_InnoventBiologicsInc.Member_F84FD00D3D7CDB047934F535B583676D" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_EB1CFDD6ACD6FA38548AF535B58392AB" xlink:to="loc_lly_InnoventBiologicsInc.Member_F84FD00D3D7CDB047934F535B583676D" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_HanmiPharmaceuticalCo.Ltd.Member" xlink:label="loc_lly_HanmiPharmaceuticalCo.Ltd.Member_716D5AD1ED3933127446F535B5836243" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_EB1CFDD6ACD6FA38548AF535B58392AB" xlink:to="loc_lly_HanmiPharmaceuticalCo.Ltd.Member_716D5AD1ED3933127446F535B5836243" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_BioNTechAGMember" xlink:label="loc_lly_BioNTechAGMember_EF4C6A4AE1578776C94DF535B5833BC9" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_EB1CFDD6ACD6FA38548AF535B58392AB" xlink:to="loc_lly_BioNTechAGMember_EF4C6A4AE1578776C94DF535B5833BC9" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_LohmannAnimalHealthMember" xlink:label="loc_lly_LohmannAnimalHealthMember_6BDDF2EBCCC30DF9080AF535B583CDA5" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_EB1CFDD6ACD6FA38548AF535B58392AB" xlink:to="loc_lly_LohmannAnimalHealthMember_6BDDF2EBCCC30DF9080AF535B583CDA5" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_NovartisAnimalHealthMember" xlink:label="loc_lly_NovartisAnimalHealthMember_6EF72D5FF04C12796C14F535B5834F3E" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_EB1CFDD6ACD6FA38548AF535B58392AB" xlink:to="loc_lly_NovartisAnimalHealthMember_6EF72D5FF04C12796C14F535B5834F3E" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_ImmunocoreLimitedMember" xlink:label="loc_lly_ImmunocoreLimitedMember_794EDBE48EFE76BEBF2EF535B5834DD7" xlink:type="locator" />
    <presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_EB1CFDD6ACD6FA38548AF535B58392AB" xlink:to="loc_lly_ImmunocoreLimitedMember_794EDBE48EFE76BEBF2EF535B5834DD7" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_LocemiaSolutionsMember" xlink:label="loc_lly_LocemiaSolutionsMember_5E472069B44306012EA1F535B58373AC" xlink:type="locator" />
    <presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_EB1CFDD6ACD6FA38548AF535B58392AB" xlink:to="loc_lly_LocemiaSolutionsMember_5E472069B44306012EA1F535B58373AC" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_OtherProductAcquisitionCounterpartyMember" xlink:label="loc_lly_OtherProductAcquisitionCounterpartyMember_4C3EDAEDE7898139766EF535B583C4F4" xlink:type="locator" />
    <presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_EB1CFDD6ACD6FA38548AF535B58392AB" xlink:to="loc_lly_OtherProductAcquisitionCounterpartyMember_4C3EDAEDE7898139766EF535B583C4F4" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_HalozymeTherapeuticsIncMember" xlink:label="loc_lly_HalozymeTherapeuticsIncMember_1EED7E44BBA97A654901F535B58393FA" xlink:type="locator" />
    <presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_EB1CFDD6ACD6FA38548AF535B58392AB" xlink:to="loc_lly_HalozymeTherapeuticsIncMember_1EED7E44BBA97A654901F535B58393FA" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_AstraZenecaMember" xlink:label="loc_lly_AstraZenecaMember_BB190E4AA0C540076082F535B583A7F6" xlink:type="locator" />
    <presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_EB1CFDD6ACD6FA38548AF535B58392AB" xlink:to="loc_lly_AstraZenecaMember_BB190E4AA0C540076082F535B583A7F6" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_AdociaMember" xlink:label="loc_lly_AdociaMember_7228128136BEC0D6ABF1F535B583F1B2" xlink:type="locator" />
    <presentationArc order="11" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_EB1CFDD6ACD6FA38548AF535B58392AB" xlink:to="loc_lly_AdociaMember_7228128136BEC0D6ABF1F535B583F1B2" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_SubsequentEventTypeAxis" xlink:label="loc_us-gaap_SubsequentEventTypeAxis_C23AD664D446DB33D1ECF535B5830768" xlink:type="locator" />
    <presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_57921B5B6CC73650CB0FF535B5830055" xlink:to="loc_us-gaap_SubsequentEventTypeAxis_C23AD664D446DB33D1ECF535B5830768" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_SubsequentEventTypeDomain" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_2C3B61A5DEBB2521687CF535B58D8E4A" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_C23AD664D446DB33D1ECF535B5830768" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_2C3B61A5DEBB2521687CF535B58D8E4A" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_SubsequentEventMember" xlink:label="loc_us-gaap_SubsequentEventMember_648E72B45671911B910FF535B58D81DE" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventTypeDomain_2C3B61A5DEBB2521687CF535B58D8E4A" xlink:to="loc_us-gaap_SubsequentEventMember_648E72B45671911B910FF535B58D81DE" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_9E2F3103F1305200768DF535B58DE25F" xlink:type="locator" />
    <presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_57921B5B6CC73650CB0FF535B5830055" xlink:to="loc_us-gaap_StatementLineItems_9E2F3103F1305200768DF535B58DE25F" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AmortizationOfIntangibleAssets" xlink:label="loc_us-gaap_AmortizationOfIntangibleAssets_FBF599E38AC9062966ABF535B58D1552" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_9E2F3103F1305200768DF535B58DE25F" xlink:to="loc_us-gaap_AmortizationOfIntangibleAssets_FBF599E38AC9062966ABF535B58D1552" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CostOfGoodsSold" xlink:label="loc_us-gaap_CostOfGoodsSold_47992E2F820763039BC8F535B58D0875" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_9E2F3103F1305200768DF535B58DE25F" xlink:to="loc_us-gaap_CostOfGoodsSold_47992E2F820763039BC8F535B58D0875" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AcquiredFiniteLivedIntangibleAssetsWeightedAverageUsefulLife" xlink:label="loc_us-gaap_AcquiredFiniteLivedIntangibleAssetsWeightedAverageUsefulLife_A93767DFC349B142CB58F535B58DCA6E" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_9E2F3103F1305200768DF535B58DE25F" xlink:to="loc_us-gaap_AcquiredFiniteLivedIntangibleAssetsWeightedAverageUsefulLife_A93767DFC349B142CB58F535B58DCA6E" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_BusinessAcquisitionPurchasePriceAllocationGoodwillExpectedTaxDeductibleAmount" xlink:label="loc_us-gaap_BusinessAcquisitionPurchasePriceAllocationGoodwillExpectedTaxDeductibleAmount_E159AF53D9B3782BE9BAF535B58D65EF" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_9E2F3103F1305200768DF535B58DE25F" xlink:to="loc_us-gaap_BusinessAcquisitionPurchasePriceAllocationGoodwillExpectedTaxDeductibleAmount_E159AF53D9B3782BE9BAF535B58D65EF" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedInventory" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedInventory_00B3AACBA089549C4701F535B58D772A" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_9E2F3103F1305200768DF535B58DE25F" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedInventory_00B3AACBA089549C4701F535B58D772A" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_InterestExpense" xlink:label="loc_us-gaap_InterestExpense_035D745B5250DB79CC07F535B58D7DEC" xlink:type="locator" />
    <presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_9E2F3103F1305200768DF535B58DE25F" xlink:to="loc_us-gaap_InterestExpense_035D745B5250DB79CC07F535B58D7DEC" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_BusinessCombinationProFormaInformationRevenueOfAcquireeSinceAcquisitionDateActual" xlink:label="loc_us-gaap_BusinessCombinationProFormaInformationRevenueOfAcquireeSinceAcquisitionDateActual_691AB02E1B65676A0CDAF535B58DA71E" xlink:type="locator" />
    <presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_9E2F3103F1305200768DF535B58DE25F" xlink:to="loc_us-gaap_BusinessCombinationProFormaInformationRevenueOfAcquireeSinceAcquisitionDateActual_691AB02E1B65676A0CDAF535B58DA71E" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_BusinessCombinationConsiderationTransferred1" xlink:label="loc_us-gaap_BusinessCombinationConsiderationTransferred1_1FAEE9BD0B53B8FFEF24F535B58D4603" xlink:type="locator" />
    <presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_9E2F3103F1305200768DF535B58DE25F" xlink:to="loc_us-gaap_BusinessCombinationConsiderationTransferred1_1FAEE9BD0B53B8FFEF24F535B58D4603" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_RestrictedCashAndCashEquivalentsNoncurrent" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalentsNoncurrent_107CB4F4E24317C381D8F535B58DBD6B" xlink:type="locator" />
    <presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_9E2F3103F1305200768DF535B58DE25F" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalentsNoncurrent_107CB4F4E24317C381D8F535B58DBD6B" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ProceedsFromDivestitureOfBusinesses" xlink:label="loc_us-gaap_ProceedsFromDivestitureOfBusinesses_1034248AC9DCCA860241F535B58D3D91" xlink:type="locator" />
    <presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_9E2F3103F1305200768DF535B58DE25F" xlink:to="loc_us-gaap_ProceedsFromDivestitureOfBusinesses_1034248AC9DCCA860241F535B58D3D91" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_BusinessAcquisitionsProFormaRevenue" xlink:label="loc_us-gaap_BusinessAcquisitionsProFormaRevenue_ACAAA7CCE0D6D35DB32AF535B58DC242" xlink:type="locator" />
    <presentationArc order="11" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_9E2F3103F1305200768DF535B58DE25F" xlink:to="loc_us-gaap_BusinessAcquisitionsProFormaRevenue_ACAAA7CCE0D6D35DB32AF535B58DC242" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles_0D516796162C46EFDE98F535B58D9F55" xlink:type="locator" />
    <presentationArc order="12" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_9E2F3103F1305200768DF535B58DE25F" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles_0D516796162C46EFDE98F535B58D9F55" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedFiniteLivedIntangiblesOtherIntangibleAssets" xlink:label="loc_lly_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedFiniteLivedIntangiblesOtherIntangibleAssets_5882A3CCECF011500A7BF535B58D58F7" xlink:type="locator" />
    <presentationArc order="13" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_9E2F3103F1305200768DF535B58DE25F" xlink:to="loc_lly_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedFiniteLivedIntangiblesOtherIntangibleAssets_5882A3CCECF011500A7BF535B58D58F7" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIndefiniteLivedIntangibleAssets" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIndefiniteLivedIntangibleAssets_CF5493E2A0EFC0B5D977F535B58D1F23" xlink:type="locator" />
    <presentationArc order="14" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_9E2F3103F1305200768DF535B58DE25F" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIndefiniteLivedIntangibleAssets_CF5493E2A0EFC0B5D977F535B58D1F23" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_91C918E845B10F9D9685F535B58DDB02" xlink:type="locator" />
    <presentationArc order="15" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_9E2F3103F1305200768DF535B58DE25F" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_91C918E845B10F9D9685F535B58DDB02" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_BusinessAcquisitionProductsOrOtherAssetsAcquired" xlink:label="loc_lly_BusinessAcquisitionProductsOrOtherAssetsAcquired_3ED4FBEFD3C998B9D173F535B58D7E0A" xlink:type="locator" />
    <presentationArc order="16" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_9E2F3103F1305200768DF535B58DE25F" xlink:to="loc_lly_BusinessAcquisitionProductsOrOtherAssetsAcquired_3ED4FBEFD3C998B9D173F535B58D7E0A" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_AcquiredInProcessResearchAndDevelopment" xlink:label="loc_lly_AcquiredInProcessResearchAndDevelopment_94486EAB67740A0A6A4DF535B58DF93C" xlink:type="locator" />
    <presentationArc order="17" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_9E2F3103F1305200768DF535B58DE25F" xlink:to="loc_lly_AcquiredInProcessResearchAndDevelopment_94486EAB67740A0A6A4DF535B58DF93C" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired" xlink:label="loc_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_5CAAE9B391C0F2EC7CB8F535B58DDE49" xlink:type="locator" />
    <presentationArc order="18" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_9E2F3103F1305200768DF535B58DE25F" xlink:to="loc_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_5CAAE9B391C0F2EC7CB8F535B58DDE49" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesLongTermDebt" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesLongTermDebt_D3BAD76D0EE6B43A7493F535B58D093B" xlink:type="locator" />
    <presentationArc order="19" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_9E2F3103F1305200768DF535B58DE25F" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesLongTermDebt_D3BAD76D0EE6B43A7493F535B58D093B" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment_E272B06AE8A9832DAF07F535B58D5279" xlink:type="locator" />
    <presentationArc order="20" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_9E2F3103F1305200768DF535B58DE25F" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment_E272B06AE8A9832DAF07F535B58D5279" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_Goodwill" xlink:label="loc_us-gaap_Goodwill_CF12EB16C97BC3F332B2F535B58D69EE" xlink:type="locator" />
    <presentationArc order="21" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_9E2F3103F1305200768DF535B58DE25F" xlink:to="loc_us-gaap_Goodwill_CF12EB16C97BC3F332B2F535B58D69EE" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxLiabilitiesNoncurrent" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxLiabilitiesNoncurrent_2E799876C28FE07C16BBF535B58DC2E8" xlink:type="locator" />
    <presentationArc order="22" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_9E2F3103F1305200768DF535B58DE25F" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxLiabilitiesNoncurrent_2E799876C28FE07C16BBF535B58DC2E8" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssets" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssets_3CE0CFBFFC6F19334AFBF535B58D31B7" xlink:type="locator" />
    <presentationArc order="23" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_9E2F3103F1305200768DF535B58DE25F" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssets_3CE0CFBFFC6F19334AFBF535B58D31B7" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsOther" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsOther_D9DD074D61B207BB84FAF535B58D652B" xlink:type="locator" />
    <presentationArc order="24" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_9E2F3103F1305200768DF535B58DE25F" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsOther_D9DD074D61B207BB84FAF535B58D652B" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilitiesOther" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilitiesOther_CAF0FB49DE92AE0925A5F535B58DC6FB" xlink:type="locator" />
    <presentationArc order="25" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_9E2F3103F1305200768DF535B58DE25F" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilitiesOther_CAF0FB49DE92AE0925A5F535B58DC6FB" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities_A492E4BBAC744B1D2E51F535B58D9B87" xlink:type="locator" />
    <presentationArc order="26" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_9E2F3103F1305200768DF535B58DE25F" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities_A492E4BBAC744B1D2E51F535B58D9B87" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet_E50287D7F2451697A9B0F535B58D6249" xlink:type="locator" />
    <presentationArc order="27" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_9E2F3103F1305200768DF535B58DE25F" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet_E50287D7F2451697A9B0F535B58D6249" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_BusinessAcquisitionsProFormaNetIncomeLoss" xlink:label="loc_us-gaap_BusinessAcquisitionsProFormaNetIncomeLoss_0F360123C87170BF51CFF535B58D5C48" xlink:type="locator" />
    <presentationArc order="28" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_9E2F3103F1305200768DF535B58DE25F" xlink:to="loc_us-gaap_BusinessAcquisitionsProFormaNetIncomeLoss_0F360123C87170BF51CFF535B58D5C48" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_BusinessAcquisitionProFormaEarningsPerShareDiluted" xlink:label="loc_us-gaap_BusinessAcquisitionProFormaEarningsPerShareDiluted_F12EB71CD8FE1549F684F535B58DCAFE" xlink:type="locator" />
    <presentationArc order="29" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_9E2F3103F1305200768DF535B58DE25F" xlink:to="loc_us-gaap_BusinessAcquisitionProFormaEarningsPerShareDiluted_F12EB71CD8FE1549F684F535B58DCAFE" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.lilly.com/role/AssetImpairmentsRestructuringAndOtherSpecialCharges" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ExtraordinaryAndUnusualItemsAbstract" xlink:label="loc_us-gaap_ExtraordinaryAndUnusualItemsAbstract_F0B8D511727BCF4CF7A1F69FEDED9133" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_UnusualOrInfrequentItemsDisclosureTextBlock" xlink:label="loc_us-gaap_UnusualOrInfrequentItemsDisclosureTextBlock_A07C7E14654DE3FAB0B8F5374ABAD31D" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ExtraordinaryAndUnusualItemsAbstract_F0B8D511727BCF4CF7A1F69FEDED9133" xlink:to="loc_us-gaap_UnusualOrInfrequentItemsDisclosureTextBlock_A07C7E14654DE3FAB0B8F5374ABAD31D" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.lilly.com/role/AssetImpairmentsRestructuringAndOtherSpecialChargesDetails" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ExtraordinaryAndUnusualItemsAbstract" xlink:label="loc_us-gaap_ExtraordinaryAndUnusualItemsAbstract_C4E132A1E78B98BA0875F6A83D763932" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_UnusualOrInfrequentItemTable" xlink:label="loc_us-gaap_UnusualOrInfrequentItemTable_50A3790D2EC3CCF38A23F6A7B7A8ACF2" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ExtraordinaryAndUnusualItemsAbstract_C4E132A1E78B98BA0875F6A83D763932" xlink:to="loc_us-gaap_UnusualOrInfrequentItemTable_50A3790D2EC3CCF38A23F6A7B7A8ACF2" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_SubsequentEventTypeAxis" xlink:label="loc_us-gaap_SubsequentEventTypeAxis_D4FAD9F65AC95C923835F6A7B7A83E3F" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_UnusualOrInfrequentItemTable_50A3790D2EC3CCF38A23F6A7B7A8ACF2" xlink:to="loc_us-gaap_SubsequentEventTypeAxis_D4FAD9F65AC95C923835F6A7B7A83E3F" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_SubsequentEventTypeDomain" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_BC748015E4BF64973924F6A7B7A8DE64" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_D4FAD9F65AC95C923835F6A7B7A83E3F" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_BC748015E4BF64973924F6A7B7A8DE64" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_SubsequentEventMember" xlink:label="loc_us-gaap_SubsequentEventMember_E04FC25F1EE65ECC29E1F6A7B7A81B8C" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventTypeDomain_BC748015E4BF64973924F6A7B7A8DE64" xlink:to="loc_us-gaap_SubsequentEventMember_E04FC25F1EE65ECC29E1F6A7B7A81B8C" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StatementBusinessSegmentsAxis" xlink:label="loc_us-gaap_StatementBusinessSegmentsAxis_AF1EE184646AD85C4D67F6A7B7A8FF5D" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_UnusualOrInfrequentItemTable_50A3790D2EC3CCF38A23F6A7B7A8ACF2" xlink:to="loc_us-gaap_StatementBusinessSegmentsAxis_AF1EE184646AD85C4D67F6A7B7A8FF5D" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_SegmentDomain" xlink:label="loc_us-gaap_SegmentDomain_AEBBF11B396BD3424DF6F6A7B7A8CB00" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_AF1EE184646AD85C4D67F6A7B7A8FF5D" xlink:to="loc_us-gaap_SegmentDomain_AEBBF11B396BD3424DF6F6A7B7A8CB00" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_HumanPharmaceuticalProductsMember" xlink:label="loc_lly_HumanPharmaceuticalProductsMember_552133EA27083B0C3025F6A7B7A9292D" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentDomain_AEBBF11B396BD3424DF6F6A7B7A8CB00" xlink:to="loc_lly_HumanPharmaceuticalProductsMember_552133EA27083B0C3025F6A7B7A9292D" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_AnimalHealthProductsMember" xlink:label="loc_lly_AnimalHealthProductsMember_78EEE33972CD360545A8F6A7B7A9AAE5" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentDomain_AEBBF11B396BD3424DF6F6A7B7A8CB00" xlink:to="loc_lly_AnimalHealthProductsMember_78EEE33972CD360545A8F6A7B7A9AAE5" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StatementGeographicalAxis" xlink:label="loc_us-gaap_StatementGeographicalAxis_E8B3CC1C0F1E1FD4839DF6A7B7A9AD6E" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_UnusualOrInfrequentItemTable_50A3790D2EC3CCF38A23F6A7B7A8ACF2" xlink:to="loc_us-gaap_StatementGeographicalAxis_E8B3CC1C0F1E1FD4839DF6A7B7A9AD6E" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_SegmentGeographicalDomain" xlink:label="loc_us-gaap_SegmentGeographicalDomain_A4C7FE57FB3871128C19F6A7B7A9A7D5" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementGeographicalAxis_E8B3CC1C0F1E1FD4839DF6A7B7A9AD6E" xlink:to="loc_us-gaap_SegmentGeographicalDomain_A4C7FE57FB3871128C19F6A7B7A9A7D5" xlink:type="arc" />
    <loc xlink:href="http://xbrl.sec.gov/country/2013/country-2013-01-31.xsd#country_PR" xlink:label="loc_country_PR_52FFBAB60F7BD9B271C8F6A7B7A9A60C" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentGeographicalDomain_A4C7FE57FB3871128C19F6A7B7A9A7D5" xlink:to="loc_country_PR_52FFBAB60F7BD9B271C8F6A7B7A9A60C" xlink:type="arc" />
    <loc xlink:href="http://xbrl.sec.gov/country/2013/country-2013-01-31.xsd#country_IE" xlink:label="loc_country_IE_0EA976898CB4B1CF4404F6A7B7A9159D" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentGeographicalDomain_A4C7FE57FB3871128C19F6A7B7A9A7D5" xlink:to="loc_country_IE_0EA976898CB4B1CF4404F6A7B7A9159D" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ProductOrServiceAxis" xlink:label="loc_us-gaap_ProductOrServiceAxis_31BF9E54CFD858B8F157F6A7B7A9FB0A" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_UnusualOrInfrequentItemTable_50A3790D2EC3CCF38A23F6A7B7A8ACF2" xlink:to="loc_us-gaap_ProductOrServiceAxis_31BF9E54CFD858B8F157F6A7B7A9FB0A" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ProductsAndServicesDomain" xlink:label="loc_us-gaap_ProductsAndServicesDomain_B409AB7310D0EAA98016F6A7B7A90AA8" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ProductOrServiceAxis_31BF9E54CFD858B8F157F6A7B7A9FB0A" xlink:to="loc_us-gaap_ProductsAndServicesDomain_B409AB7310D0EAA98016F6A7B7A90AA8" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_UnusualOrInfrequentItemAxis" xlink:label="loc_us-gaap_UnusualOrInfrequentItemAxis_D40832A0E27BB8A006D1F6A7B7A91650" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_UnusualOrInfrequentItemTable_50A3790D2EC3CCF38A23F6A7B7A8ACF2" xlink:to="loc_us-gaap_UnusualOrInfrequentItemAxis_D40832A0E27BB8A006D1F6A7B7A91650" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_UnusualOrInfrequentItemDomain" xlink:label="loc_us-gaap_UnusualOrInfrequentItemDomain_09A0D8C698F96F0B47DEF6A7B7AAA51A" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_UnusualOrInfrequentItemAxis_D40832A0E27BB8A006D1F6A7B7A91650" xlink:to="loc_us-gaap_UnusualOrInfrequentItemDomain_09A0D8C698F96F0B47DEF6A7B7AAA51A" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_UnusualOrInfrequentItemLineItems" xlink:label="loc_us-gaap_UnusualOrInfrequentItemLineItems_194ECC2E53A138C731DEF6A7B7AA8CE7" xlink:type="locator" />
    <presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_UnusualOrInfrequentItemTable_50A3790D2EC3CCF38A23F6A7B7A8ACF2" xlink:to="loc_us-gaap_UnusualOrInfrequentItemLineItems_194ECC2E53A138C731DEF6A7B7AA8CE7" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AssetImpairmentCharges" xlink:label="loc_us-gaap_AssetImpairmentCharges_DADA59932F00665C2F3AF6A7B7AA475A" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_UnusualOrInfrequentItemLineItems_194ECC2E53A138C731DEF6A7B7AA8CE7" xlink:to="loc_us-gaap_AssetImpairmentCharges_DADA59932F00665C2F3AF6A7B7AA475A" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_SeveranceCosts1" xlink:label="loc_us-gaap_SeveranceCosts1_272BD7E0BFF5811BA508F6A7B7AA6152" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_UnusualOrInfrequentItemLineItems_194ECC2E53A138C731DEF6A7B7AA8CE7" xlink:to="loc_us-gaap_SeveranceCosts1_272BD7E0BFF5811BA508F6A7B7AA6152" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_RestructuringSettlementAndImpairmentProvisions" xlink:label="loc_us-gaap_RestructuringSettlementAndImpairmentProvisions_5C1C60D762DDBDE49A90F6A7B7AA078F" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_UnusualOrInfrequentItemLineItems_194ECC2E53A138C731DEF6A7B7AA8CE7" xlink:to="loc_us-gaap_RestructuringSettlementAndImpairmentProvisions_5C1C60D762DDBDE49A90F6A7B7AA078F" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.lilly.com/role/AssetImpairmentsRestructuringAndOtherSpecialChargesTables" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ExtraordinaryAndUnusualItemsAbstract" xlink:label="loc_us-gaap_ExtraordinaryAndUnusualItemsAbstract_1EC805E43FA473F34116F6A0284B4C38" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScheduleOfUnusualOrInfrequentItemsTextBlock" xlink:label="loc_us-gaap_ScheduleOfUnusualOrInfrequentItemsTextBlock_F58439CA2C61A4F596C9F5374AB8A339" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ExtraordinaryAndUnusualItemsAbstract_1EC805E43FA473F34116F6A0284B4C38" xlink:to="loc_us-gaap_ScheduleOfUnusualOrInfrequentItemsTextBlock_F58439CA2C61A4F596C9F5374AB8A339" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.lilly.com/role/Borrowings" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_LongtermDebtCurrentAndNoncurrentAbstract" xlink:label="loc_us-gaap_LongtermDebtCurrentAndNoncurrentAbstract_AAB2166BC59CF4B24E9BFC036F158F4A" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DebtDisclosureTextBlock" xlink:label="loc_us-gaap_DebtDisclosureTextBlock_94792CD7E56F44C9BDB7FC036F15F1AE" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongtermDebtCurrentAndNoncurrentAbstract_AAB2166BC59CF4B24E9BFC036F158F4A" xlink:to="loc_us-gaap_DebtDisclosureTextBlock_94792CD7E56F44C9BDB7FC036F15F1AE" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.lilly.com/role/BorrowingsDetails" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_LongtermDebtCurrentAndNoncurrentAbstract" xlink:label="loc_us-gaap_LongtermDebtCurrentAndNoncurrentAbstract_0264C50A68241E9F36B5FB13C740B8B8" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DebtInstrumentTable" xlink:label="loc_us-gaap_DebtInstrumentTable_F9B01B7CB6F9B5BF1009FB13C740424B" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongtermDebtCurrentAndNoncurrentAbstract_0264C50A68241E9F36B5FB13C740B8B8" xlink:to="loc_us-gaap_DebtInstrumentTable_F9B01B7CB6F9B5BF1009FB13C740424B" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DebtInstrumentAxis" xlink:label="loc_us-gaap_DebtInstrumentAxis_13403C185DA29E2B0E69FB13C740CCE9" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_F9B01B7CB6F9B5BF1009FB13C740424B" xlink:to="loc_us-gaap_DebtInstrumentAxis_13403C185DA29E2B0E69FB13C740CCE9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DebtInstrumentNameDomain" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_E645A5D4782F6A4F442DFB13C740AEB6" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentAxis_13403C185DA29E2B0E69FB13C740CCE9" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_E645A5D4782F6A4F442DFB13C740AEB6" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FairValueByMeasurementBasisAxis" xlink:label="loc_us-gaap_FairValueByMeasurementBasisAxis_F103ED0111E156D7C1DCFB13C7403A6C" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_F9B01B7CB6F9B5BF1009FB13C740424B" xlink:to="loc_us-gaap_FairValueByMeasurementBasisAxis_F103ED0111E156D7C1DCFB13C7403A6C" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FairValueDisclosureItemAmountsDomain" xlink:label="loc_us-gaap_FairValueDisclosureItemAmountsDomain_CDC5DEB61EC55066425FFB13C740B1CF" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByMeasurementBasisAxis_F103ED0111E156D7C1DCFB13C7403A6C" xlink:to="loc_us-gaap_FairValueDisclosureItemAmountsDomain_CDC5DEB61EC55066425FFB13C740B1CF" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PortionAtFairValueFairValueDisclosureMember" xlink:label="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_254F75519ED32B8E3AF6FB1C9CB7A7A9" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosureItemAmountsDomain_CDC5DEB61EC55066425FFB13C740B1CF" xlink:to="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_254F75519ED32B8E3AF6FB1C9CB7A7A9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CarryingReportedAmountFairValueDisclosureMember" xlink:label="loc_us-gaap_CarryingReportedAmountFairValueDisclosureMember_55904108A8ACD079ECE5FB13C7402BD7" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosureItemAmountsDomain_CDC5DEB61EC55066425FFB13C740B1CF" xlink:to="loc_us-gaap_CarryingReportedAmountFairValueDisclosureMember_55904108A8ACD079ECE5FB13C7402BD7" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DebtInstrumentRedemptionPeriodAxis" xlink:label="loc_us-gaap_DebtInstrumentRedemptionPeriodAxis_574F6DFBD1A0E107A4ABFB13C7413CDB" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_F9B01B7CB6F9B5BF1009FB13C740424B" xlink:to="loc_us-gaap_DebtInstrumentRedemptionPeriodAxis_574F6DFBD1A0E107A4ABFB13C7413CDB" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DebtInstrumentRedemptionPeriodDomain" xlink:label="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_A69214F22BF036F532ADFB13C741FCE7" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentRedemptionPeriodAxis_574F6DFBD1A0E107A4ABFB13C7413CDB" xlink:to="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_A69214F22BF036F532ADFB13C741FCE7" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_MaturityDate2020Member" xlink:label="loc_lly_MaturityDate2020Member_86391C5A8E9B64DE881EFB13C741C501" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_A69214F22BF036F532ADFB13C741FCE7" xlink:to="loc_lly_MaturityDate2020Member_86391C5A8E9B64DE881EFB13C741C501" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_MaturityDate2019Member" xlink:label="loc_lly_MaturityDate2019Member_1A841CF2D943B78883AFFB13C7418D23" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_A69214F22BF036F532ADFB13C741FCE7" xlink:to="loc_lly_MaturityDate2019Member_1A841CF2D943B78883AFFB13C7418D23" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_MaturityDate2015Member" xlink:label="loc_lly_MaturityDate2015Member_BEC80FD267B4B17F8CD3FB13C741C976" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_A69214F22BF036F532ADFB13C741FCE7" xlink:to="loc_lly_MaturityDate2015Member_BEC80FD267B4B17F8CD3FB13C741C976" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_MaturityDate2018Member" xlink:label="loc_lly_MaturityDate2018Member_6F429400A5B7D024885FFB13C74166F1" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_A69214F22BF036F532ADFB13C741FCE7" xlink:to="loc_lly_MaturityDate2018Member_6F429400A5B7D024885FFB13C74166F1" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_MaturityDate2025Member" xlink:label="loc_lly_MaturityDate2025Member_F3062A0D2669C5E74AB9FB13C74148EC" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_A69214F22BF036F532ADFB13C741FCE7" xlink:to="loc_lly_MaturityDate2025Member_F3062A0D2669C5E74AB9FB13C74148EC" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_MaturityDate2045Member" xlink:label="loc_lly_MaturityDate2045Member_B82DA8AFD5445E4A1C1AFB13C741893F" xlink:type="locator" />
    <presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_A69214F22BF036F532ADFB13C741FCE7" xlink:to="loc_lly_MaturityDate2045Member_B82DA8AFD5445E4A1C1AFB13C741893F" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_MaturityDate2022MemberMember" xlink:label="loc_lly_MaturityDate2022MemberMember_A55AC1FD881CCDA9755AFB13C7419C8C" xlink:type="locator" />
    <presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_A69214F22BF036F532ADFB13C741FCE7" xlink:to="loc_lly_MaturityDate2022MemberMember_A55AC1FD881CCDA9755AFB13C7419C8C" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_MaturityDate2026Member" xlink:label="loc_lly_MaturityDate2026Member_AFA0224289BBB8FD3E0CFB13C7417DA8" xlink:type="locator" />
    <presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_A69214F22BF036F532ADFB13C741FCE7" xlink:to="loc_lly_MaturityDate2026Member_AFA0224289BBB8FD3E0CFB13C7417DA8" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_MaturityDate2030Member" xlink:label="loc_lly_MaturityDate2030Member_5F80D3BD700973B027D5FB13C7413B48" xlink:type="locator" />
    <presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_A69214F22BF036F532ADFB13C741FCE7" xlink:to="loc_lly_MaturityDate2030Member_5F80D3BD700973B027D5FB13C7413B48" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_EuroDenominatedDebtIssuanceMember" xlink:label="loc_lly_EuroDenominatedDebtIssuanceMember_39D29BDBEA602C415A3AFB13C74174CE" xlink:type="locator" />
    <presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_A69214F22BF036F532ADFB13C741FCE7" xlink:to="loc_lly_EuroDenominatedDebtIssuanceMember_39D29BDBEA602C415A3AFB13C74174CE" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_MaturityDate2044Member" xlink:label="loc_lly_MaturityDate2044Member_B7F4512EB436A38BCFADFB13C74193C9" xlink:type="locator" />
    <presentationArc order="11" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_A69214F22BF036F532ADFB13C741FCE7" xlink:to="loc_lly_MaturityDate2044Member_B7F4512EB436A38BCFADFB13C74193C9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_CF64F187A69DF2596CF6FB13C74188ED" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_F9B01B7CB6F9B5BF1009FB13C740424B" xlink:to="loc_us-gaap_StatementLineItems_CF64F187A69DF2596CF6FB13C74188ED" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CommercialPaper" xlink:label="loc_us-gaap_CommercialPaper_BFACA443AD708AD9F5DEFB13C741F06B" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_CF64F187A69DF2596CF6FB13C74188ED" xlink:to="loc_us-gaap_CommercialPaper_BFACA443AD708AD9F5DEFB13C741F06B" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DebtCurrent" xlink:label="loc_us-gaap_DebtCurrent_D79F1C275C2CDC5F6E6CFB13C741CCE3" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_CF64F187A69DF2596CF6FB13C74188ED" xlink:to="loc_us-gaap_DebtCurrent_D79F1C275C2CDC5F6E6CFB13C741CCE3" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ShortTermDebtWeightedAverageInterestRate" xlink:label="loc_us-gaap_ShortTermDebtWeightedAverageInterestRate_A09C4D65CAAE69A72FE7FB13C741E8CA" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_CF64F187A69DF2596CF6FB13C74188ED" xlink:to="loc_us-gaap_ShortTermDebtWeightedAverageInterestRate_A09C4D65CAAE69A72FE7FB13C741E8CA" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DebtInstrumentInterestRateStatedPercentageRateRangeMinimum" xlink:label="loc_us-gaap_DebtInstrumentInterestRateStatedPercentageRateRangeMinimum_0D584C63C9BE7195FB23FB13C7416CFC" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_CF64F187A69DF2596CF6FB13C74188ED" xlink:to="loc_us-gaap_DebtInstrumentInterestRateStatedPercentageRateRangeMinimum_0D584C63C9BE7195FB23FB13C7416CFC" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_RepaymentsOfLongTermDebt" xlink:label="loc_us-gaap_RepaymentsOfLongTermDebt_09DB0E15F27B8177D4B5FB13C7427572" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_CF64F187A69DF2596CF6FB13C74188ED" xlink:to="loc_us-gaap_RepaymentsOfLongTermDebt_09DB0E15F27B8177D4B5FB13C7427572" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ExtinguishmentOfDebtAmount" xlink:label="loc_us-gaap_ExtinguishmentOfDebtAmount_7B6570F716F8DC097BA7FB13C7420867" xlink:type="locator" />
    <presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_CF64F187A69DF2596CF6FB13C74188ED" xlink:to="loc_us-gaap_ExtinguishmentOfDebtAmount_7B6570F716F8DC097BA7FB13C7420867" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_GainsLossesOnExtinguishmentOfDebt" xlink:label="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_AA416B8B0DFDC68546F0FB13C74248CD" xlink:type="locator" />
    <presentationArc order="7" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_CF64F187A69DF2596CF6FB13C74188ED" xlink:to="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_AA416B8B0DFDC68546F0FB13C74248CD" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_NotesPayable" xlink:label="loc_us-gaap_NotesPayable_CF558C7DC1FEBC514C1BFB13C742F58D" xlink:type="locator" />
    <presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_CF64F187A69DF2596CF6FB13C74188ED" xlink:to="loc_us-gaap_NotesPayable_CF558C7DC1FEBC514C1BFB13C742F58D" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OtherNotesPayable" xlink:label="loc_us-gaap_OtherNotesPayable_C3AF051EF144F23488D2FB13C7426CA8" xlink:type="locator" />
    <presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_CF64F187A69DF2596CF6FB13C74188ED" xlink:to="loc_us-gaap_OtherNotesPayable_C3AF051EF144F23488D2FB13C7426CA8" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_UnamortizedDebtIssuanceExpense" xlink:label="loc_us-gaap_UnamortizedDebtIssuanceExpense_FDB6119949A32D09E491FB13C7422583" xlink:type="locator" />
    <presentationArc order="10" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_CF64F187A69DF2596CF6FB13C74188ED" xlink:to="loc_us-gaap_UnamortizedDebtIssuanceExpense_FDB6119949A32D09E491FB13C7422583" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_LongTermDebtFairValueAdjustment" xlink:label="loc_lly_LongTermDebtFairValueAdjustment_5880E79CA0CDCDBA836FFB13C7422075" xlink:type="locator" />
    <presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_CF64F187A69DF2596CF6FB13C74188ED" xlink:to="loc_lly_LongTermDebtFairValueAdjustment_5880E79CA0CDCDBA836FFB13C7422075" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DebtLongtermAndShorttermCombinedAmount" xlink:label="loc_us-gaap_DebtLongtermAndShorttermCombinedAmount_3D42FF1C66D2372B0182FB13C74299DE" xlink:type="locator" />
    <presentationArc order="12" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_CF64F187A69DF2596CF6FB13C74188ED" xlink:to="loc_us-gaap_DebtLongtermAndShorttermCombinedAmount_3D42FF1C66D2372B0182FB13C74299DE" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_LongTermDebtNoncurrent" xlink:label="loc_us-gaap_LongTermDebtNoncurrent_4711B1D0829873EEED79FB13C74200A3" xlink:type="locator" />
    <presentationArc order="13" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_CF64F187A69DF2596CF6FB13C74188ED" xlink:to="loc_us-gaap_LongTermDebtNoncurrent_4711B1D0829873EEED79FB13C74200A3" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_DescriptionOfDerivativeActivityVolumePercent" xlink:label="loc_lly_DescriptionOfDerivativeActivityVolumePercent_57E5B3B0D9D0E3D0F10DFB13C742BEE7" xlink:type="locator" />
    <presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_CF64F187A69DF2596CF6FB13C74188ED" xlink:to="loc_lly_DescriptionOfDerivativeActivityVolumePercent_57E5B3B0D9D0E3D0F10DFB13C742BEE7" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DebtInstrumentInterestRateStatedPercentage" xlink:label="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_2F61FC37CCBCA2B72903FB13C742813A" xlink:type="locator" />
    <presentationArc order="15" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_CF64F187A69DF2596CF6FB13C74188ED" xlink:to="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_2F61FC37CCBCA2B72903FB13C742813A" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ProceedsFromIssuanceOfLongTermDebt" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfLongTermDebt_34C6424CB82AE140797CFB13C7428A4B" xlink:type="locator" />
    <presentationArc order="16" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_CF64F187A69DF2596CF6FB13C74188ED" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfLongTermDebt_34C6424CB82AE140797CFB13C7428A4B" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_LongTermDebt" xlink:label="loc_us-gaap_LongTermDebt_14908C03588931B4985DFB13C74239A0" xlink:type="locator" />
    <presentationArc order="17" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_CF64F187A69DF2596CF6FB13C74188ED" xlink:to="loc_us-gaap_LongTermDebt_14908C03588931B4985DFB13C74239A0" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths_C4F567B02236F7E50E87FB13C742435C" xlink:type="locator" />
    <presentationArc order="18" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_CF64F187A69DF2596CF6FB13C74188ED" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths_C4F567B02236F7E50E87FB13C742435C" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo_97C809B47C1FB4749265FB13C7428ED8" xlink:type="locator" />
    <presentationArc order="19" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_CF64F187A69DF2596CF6FB13C74188ED" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo_97C809B47C1FB4749265FB13C7428ED8" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree_DBA36E920B3EE5D27EF3FB13C742DD0F" xlink:type="locator" />
    <presentationArc order="20" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_CF64F187A69DF2596CF6FB13C74188ED" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree_DBA36E920B3EE5D27EF3FB13C742DD0F" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFour" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFour_2BC7C26F2511119819A4FB13C74288A0" xlink:type="locator" />
    <presentationArc order="21" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_CF64F187A69DF2596CF6FB13C74188ED" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFour_2BC7C26F2511119819A4FB13C74288A0" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFive" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFive_3CD45E6616956E20E1F1FB13C74246FE" xlink:type="locator" />
    <presentationArc order="22" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_CF64F187A69DF2596CF6FB13C74188ED" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFive_3CD45E6616956E20E1F1FB13C74246FE" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_LineOfCreditFacilityRemainingBorrowingCapacity" xlink:label="loc_us-gaap_LineOfCreditFacilityRemainingBorrowingCapacity_696895AC9679E5255BEAFB13C74269CA" xlink:type="locator" />
    <presentationArc order="23" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_CF64F187A69DF2596CF6FB13C74188ED" xlink:to="loc_us-gaap_LineOfCreditFacilityRemainingBorrowingCapacity_696895AC9679E5255BEAFB13C74269CA" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity" xlink:label="loc_us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity_F4C019FF4CFAF93F2970FB13C7430D18" xlink:type="locator" />
    <presentationArc order="24" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_CF64F187A69DF2596CF6FB13C74188ED" xlink:to="loc_us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity_F4C019FF4CFAF93F2970FB13C7430D18" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_LineOfCreditFacilityFairValueOfAmountOutstanding" xlink:label="loc_us-gaap_LineOfCreditFacilityFairValueOfAmountOutstanding_1234FC9863F217CCD03FFB13C74315D2" xlink:type="locator" />
    <presentationArc order="25" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_CF64F187A69DF2596CF6FB13C74188ED" xlink:to="loc_us-gaap_LineOfCreditFacilityFairValueOfAmountOutstanding_1234FC9863F217CCD03FFB13C74315D2" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_InterestPaidNet" xlink:label="loc_us-gaap_InterestPaidNet_5610016CD545EE65E9DFFB13C7438F75" xlink:type="locator" />
    <presentationArc order="26" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_CF64F187A69DF2596CF6FB13C74188ED" xlink:to="loc_us-gaap_InterestPaidNet_5610016CD545EE65E9DFFB13C7438F75" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DebtInstrumentInterestRateEffectivePercentage" xlink:label="loc_us-gaap_DebtInstrumentInterestRateEffectivePercentage_1E8AB79BCDC96D3960A4FB13C743BC92" xlink:type="locator" />
    <presentationArc order="27" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_CF64F187A69DF2596CF6FB13C74188ED" xlink:to="loc_us-gaap_DebtInstrumentInterestRateEffectivePercentage_1E8AB79BCDC96D3960A4FB13C743BC92" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DebtInstrumentInterestRateStatedPercentageRateRangeMaximum" xlink:label="loc_us-gaap_DebtInstrumentInterestRateStatedPercentageRateRangeMaximum_FE4A3A20C6BAF944A8D7FB13C743FF9E" xlink:type="locator" />
    <presentationArc order="28" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_CF64F187A69DF2596CF6FB13C74188ED" xlink:to="loc_us-gaap_DebtInstrumentInterestRateStatedPercentageRateRangeMaximum_FE4A3A20C6BAF944A8D7FB13C743FF9E" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.lilly.com/role/BorrowingsTables" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_LongtermDebtCurrentAndNoncurrentAbstract" xlink:label="loc_us-gaap_LongtermDebtCurrentAndNoncurrentAbstract_873EBE27049E70313AD4F4D2AB91A18C" xlink:type="locator" />
    <loc xlink:href="lly-20151231.xsd#lly_ScheduleofAdditionalBorrowingsDisclosuresTableTextBlock" xlink:label="loc_lly_ScheduleofAdditionalBorrowingsDisclosuresTableTextBlock_4804D70674203C2BBE4BF4D4F565152F" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongtermDebtCurrentAndNoncurrentAbstract_873EBE27049E70313AD4F4D2AB91A18C" xlink:to="loc_lly_ScheduleofAdditionalBorrowingsDisclosuresTableTextBlock_4804D70674203C2BBE4BF4D4F565152F" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScheduleOfMaturitiesOfLongTermDebtTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfMaturitiesOfLongTermDebtTableTextBlock_B90F81848A27DD33A9BAF4D2AB91287F" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongtermDebtCurrentAndNoncurrentAbstract_873EBE27049E70313AD4F4D2AB91A18C" xlink:to="loc_us-gaap_ScheduleOfMaturitiesOfLongTermDebtTableTextBlock_B90F81848A27DD33A9BAF4D2AB91287F" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScheduleOfDebtTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfDebtTableTextBlock_54C1285513348F6A077BF4D2AB91AF3C" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongtermDebtCurrentAndNoncurrentAbstract_873EBE27049E70313AD4F4D2AB91A18C" xlink:to="loc_us-gaap_ScheduleOfDebtTableTextBlock_54C1285513348F6A077BF4D2AB91AF3C" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.lilly.com/role/Collaborations" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract" xlink:label="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_5E203C7B0EA2A3FEA3C1FC036FD301DB" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CollaborativeArrangementDisclosureTextBlock" xlink:label="loc_us-gaap_CollaborativeArrangementDisclosureTextBlock_FA5EBA7491D7AB6FD021FC036FD37415" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_5E203C7B0EA2A3FEA3C1FC036FD301DB" xlink:to="loc_us-gaap_CollaborativeArrangementDisclosureTextBlock_FA5EBA7491D7AB6FD021FC036FD37415" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.lilly.com/role/CollaborationsDetails" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract" xlink:label="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_CEFE9DB458E370E1CAB9F5374AC4B217" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable" xlink:label="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_C3A0D09B304D9B20A64DF5374AC40815" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_CEFE9DB458E370E1CAB9F5374AC4B217" xlink:to="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_C3A0D09B304D9B20A64DF5374AC40815" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_BusinessAcquisitionAxis" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_A3D9B0C0D78096052E8EF5374AC44A4B" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_C3A0D09B304D9B20A64DF5374AC40815" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_A3D9B0C0D78096052E8EF5374AC44A4B" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_C91B2C1C03B6A5F4E8A4F5374AC44D29" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_A3D9B0C0D78096052E8EF5374AC44A4B" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_C91B2C1C03B6A5F4E8A4F5374AC44D29" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_ErbituxAcquisitionMember" xlink:label="loc_lly_ErbituxAcquisitionMember_0E7E25F65ED1DB121CB3F5374AC46B9B" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_C91B2C1C03B6A5F4E8A4F5374AC44D29" xlink:to="loc_lly_ErbituxAcquisitionMember_0E7E25F65ED1DB121CB3F5374AC46B9B" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_TypeOfArrangementAxis" xlink:label="loc_us-gaap_TypeOfArrangementAxis_8CEAF4F49EC62098AEE5F5374AC4A9A4" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_C3A0D09B304D9B20A64DF5374AC40815" xlink:to="loc_us-gaap_TypeOfArrangementAxis_8CEAF4F49EC62098AEE5F5374AC4A9A4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_619EEB727F91175E2132F5374AC44DDB" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TypeOfArrangementAxis_8CEAF4F49EC62098AEE5F5374AC4A9A4" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_619EEB727F91175E2132F5374AC44DDB" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_RevenueShareMember" xlink:label="loc_lly_RevenueShareMember_E7689AFEA6156377BB87F5374AC5EA4C" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_619EEB727F91175E2132F5374AC44DDB" xlink:to="loc_lly_RevenueShareMember_E7689AFEA6156377BB87F5374AC5EA4C" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_MilestonePaymentsMember" xlink:label="loc_lly_MilestonePaymentsMember_6ED2B7459893F57CE1C0F5374AC5F4FD" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_619EEB727F91175E2132F5374AC44DDB" xlink:to="loc_lly_MilestonePaymentsMember_6ED2B7459893F57CE1C0F5374AC5F4FD" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_MilestonePaymentsSalesBasedMember" xlink:label="loc_lly_MilestonePaymentsSalesBasedMember_B4E269BF8ED351D159D3F5374AC5C96A" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lly_MilestonePaymentsMember_6ED2B7459893F57CE1C0F5374AC5F4FD" xlink:to="loc_lly_MilestonePaymentsSalesBasedMember_B4E269BF8ED351D159D3F5374AC5C96A" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_MilestonePaymentsDevelopmentandRegulatoryCapitalizedMember" xlink:label="loc_lly_MilestonePaymentsDevelopmentandRegulatoryCapitalizedMember_273F6830DE682E849533F5374AC5063B" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lly_MilestonePaymentsMember_6ED2B7459893F57CE1C0F5374AC5F4FD" xlink:to="loc_lly_MilestonePaymentsDevelopmentandRegulatoryCapitalizedMember_273F6830DE682E849533F5374AC5063B" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_MilestonePaymentsDevelopmentandRegulatoryCapitalizedCumulativeMember" xlink:label="loc_lly_MilestonePaymentsDevelopmentandRegulatoryCapitalizedCumulativeMember_3B141116463185DE7138F5374AC51B7F" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lly_MilestonePaymentsMember_6ED2B7459893F57CE1C0F5374AC5F4FD" xlink:to="loc_lly_MilestonePaymentsDevelopmentandRegulatoryCapitalizedCumulativeMember_3B141116463185DE7138F5374AC51B7F" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_ProfitAndDevelopmentAndMarketingShareMember" xlink:label="loc_lly_ProfitAndDevelopmentAndMarketingShareMember_056C528397BECE5E5C77F5374AC5CFCC" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_619EEB727F91175E2132F5374AC44DDB" xlink:to="loc_lly_ProfitAndDevelopmentAndMarketingShareMember_056C528397BECE5E5C77F5374AC5CFCC" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_UpfrontPaymentMember" xlink:label="loc_lly_UpfrontPaymentMember_1B0C51C6F95839244747F5374AC500F8" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_619EEB727F91175E2132F5374AC44DDB" xlink:to="loc_lly_UpfrontPaymentMember_1B0C51C6F95839244747F5374AC500F8" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_SalesReportedMember" xlink:label="loc_lly_SalesReportedMember_2819D0613992F7A9953DF5374AC5371F" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_619EEB727F91175E2132F5374AC44DDB" xlink:to="loc_lly_SalesReportedMember_2819D0613992F7A9953DF5374AC5371F" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_ResearchAndDevelopmentExpMember" xlink:label="loc_lly_ResearchAndDevelopmentExpMember_793E5DE6D296B030D9E0F5374AC587B6" xlink:type="locator" />
    <presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_619EEB727F91175E2132F5374AC44DDB" xlink:to="loc_lly_ResearchAndDevelopmentExpMember_793E5DE6D296B030D9E0F5374AC587B6" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_MilestonePaymentsDevelopmentandRegulatoryExpensedMember" xlink:label="loc_lly_MilestonePaymentsDevelopmentandRegulatoryExpensedMember_E19F01245867BF4EB82FF5374AC5B5F9" xlink:type="locator" />
    <presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_619EEB727F91175E2132F5374AC44DDB" xlink:to="loc_lly_MilestonePaymentsDevelopmentandRegulatoryExpensedMember_E19F01245867BF4EB82FF5374AC5B5F9" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_MilestonePaymentsDevelopmentAndRegulatoryMember" xlink:label="loc_lly_MilestonePaymentsDevelopmentAndRegulatoryMember_36DC08E96230AF5D480BF5374AC511A9" xlink:type="locator" />
    <presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_619EEB727F91175E2132F5374AC44DDB" xlink:to="loc_lly_MilestonePaymentsDevelopmentAndRegulatoryMember_36DC08E96230AF5D480BF5374AC511A9" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_ResearchAndDevelopmentAndMarketingAndSellingExpenseMember" xlink:label="loc_lly_ResearchAndDevelopmentAndMarketingAndSellingExpenseMember_52330E91309CFC15E084F5374AC5AA34" xlink:type="locator" />
    <presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_619EEB727F91175E2132F5374AC44DDB" xlink:to="loc_lly_ResearchAndDevelopmentAndMarketingAndSellingExpenseMember_52330E91309CFC15E084F5374AC5AA34" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_GrossMarginShareMember" xlink:label="loc_lly_GrossMarginShareMember_042869C8D42838C80090F5374AC5FA91" xlink:type="locator" />
    <presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_619EEB727F91175E2132F5374AC44DDB" xlink:to="loc_lly_GrossMarginShareMember_042869C8D42838C80090F5374AC5FA91" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_RoyaltyAgreementTermsMember" xlink:label="loc_us-gaap_RoyaltyAgreementTermsMember_34F8DA46C874E9DEBFB7F5374AC559B0" xlink:type="locator" />
    <presentationArc order="11" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_619EEB727F91175E2132F5374AC44DDB" xlink:to="loc_us-gaap_RoyaltyAgreementTermsMember_34F8DA46C874E9DEBFB7F5374AC559B0" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CollaborativeArrangementMember" xlink:label="loc_us-gaap_CollaborativeArrangementMember_1532041F1F0298ADC3F6F5374AC5D215" xlink:type="locator" />
    <presentationArc order="12" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_619EEB727F91175E2132F5374AC44DDB" xlink:to="loc_us-gaap_CollaborativeArrangementMember_1532041F1F0298ADC3F6F5374AC5D215" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StatementGeographicalAxis" xlink:label="loc_us-gaap_StatementGeographicalAxis_055F0D26F6A6CB3FA6A8F5374AC52D26" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_C3A0D09B304D9B20A64DF5374AC40815" xlink:to="loc_us-gaap_StatementGeographicalAxis_055F0D26F6A6CB3FA6A8F5374AC52D26" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_SegmentGeographicalDomain" xlink:label="loc_us-gaap_SegmentGeographicalDomain_C20CE7C0397F0206D2C8F5374AC54F95" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementGeographicalAxis_055F0D26F6A6CB3FA6A8F5374AC52D26" xlink:to="loc_us-gaap_SegmentGeographicalDomain_C20CE7C0397F0206D2C8F5374AC54F95" xlink:type="arc" />
    <loc xlink:href="http://xbrl.sec.gov/country/2013/country-2013-01-31.xsd#country_US" xlink:label="loc_country_US_8CC88BF330334F8EB06AF5374AC5F948" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentGeographicalDomain_C20CE7C0397F0206D2C8F5374AC54F95" xlink:to="loc_country_US_8CC88BF330334F8EB06AF5374AC5F948" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_OutsideUnitedStatesMember" xlink:label="loc_lly_OutsideUnitedStatesMember_545693146961753E3F11F5374AC6F43C" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentGeographicalDomain_C20CE7C0397F0206D2C8F5374AC54F95" xlink:to="loc_lly_OutsideUnitedStatesMember_545693146961753E3F11F5374AC6F43C" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ProductOrServiceAxis" xlink:label="loc_us-gaap_ProductOrServiceAxis_AA76A6E3AC942ADA6862F5374AC6BC2A" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_C3A0D09B304D9B20A64DF5374AC40815" xlink:to="loc_us-gaap_ProductOrServiceAxis_AA76A6E3AC942ADA6862F5374AC6BC2A" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ProductsAndServicesDomain" xlink:label="loc_us-gaap_ProductsAndServicesDomain_59838AAD98689BE57045F5374AC648EA" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ProductOrServiceAxis_AA76A6E3AC942ADA6862F5374AC6BC2A" xlink:to="loc_us-gaap_ProductsAndServicesDomain_59838AAD98689BE57045F5374AC648EA" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_ErbituxAPIMember" xlink:label="loc_lly_ErbituxAPIMember_D41F40520DD611BDBF89F5374AC6C18B" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ProductsAndServicesDomain_59838AAD98689BE57045F5374AC648EA" xlink:to="loc_lly_ErbituxAPIMember_D41F40520DD611BDBF89F5374AC6C18B" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_ErbituxMember" xlink:label="loc_lly_ErbituxMember_09AE8911FB3612A24FC4F5374AC68CE6" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ProductsAndServicesDomain_59838AAD98689BE57045F5374AC648EA" xlink:to="loc_lly_ErbituxMember_09AE8911FB3612A24FC4F5374AC68CE6" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_TrajentaBIMember" xlink:label="loc_lly_TrajentaBIMember_CC20BBE06A8E6429A43FF5374AC60CC1" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ProductsAndServicesDomain_59838AAD98689BE57045F5374AC648EA" xlink:to="loc_lly_TrajentaBIMember_CC20BBE06A8E6429A43FF5374AC60CC1" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_EffientMember" xlink:label="loc_lly_EffientMember_7C370569B56D92C55DF8F5374AC6DD3E" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ProductsAndServicesDomain_59838AAD98689BE57045F5374AC648EA" xlink:to="loc_lly_EffientMember_7C370569B56D92C55DF8F5374AC6DD3E" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_AmylinMember" xlink:label="loc_lly_AmylinMember_83959E4F7C6B25F378EBF5374AC68672" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ProductsAndServicesDomain_59838AAD98689BE57045F5374AC648EA" xlink:to="loc_lly_AmylinMember_83959E4F7C6B25F378EBF5374AC68672" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_ExenatideMember" xlink:label="loc_lly_ExenatideMember_1808FF4446D447832747F5374AC6FA62" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lly_AmylinMember_83959E4F7C6B25F378EBF5374AC68672" xlink:to="loc_lly_ExenatideMember_1808FF4446D447832747F5374AC6FA62" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_SolanezumabMember" xlink:label="loc_lly_SolanezumabMember_6BC9853FF7AC35FE5417F5374AC6228E" xlink:type="locator" />
    <presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ProductsAndServicesDomain_59838AAD98689BE57045F5374AC648EA" xlink:to="loc_lly_SolanezumabMember_6BC9853FF7AC35FE5417F5374AC6228E" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_BoerhringerIngelheimBiMember" xlink:label="loc_lly_BoerhringerIngelheimBiMember_97BBCB7BE8621A4D93B5F5374AC66F37" xlink:type="locator" />
    <presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ProductsAndServicesDomain_59838AAD98689BE57045F5374AC648EA" xlink:to="loc_lly_BoerhringerIngelheimBiMember_97BBCB7BE8621A4D93B5F5374AC66F37" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_BiCompoundsMember" xlink:label="loc_lly_BiCompoundsMember_398E58DEF2939C5CD794F5374AC6B3DC" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lly_BoerhringerIngelheimBiMember_97BBCB7BE8621A4D93B5F5374AC66F37" xlink:to="loc_lly_BiCompoundsMember_398E58DEF2939C5CD794F5374AC6B3DC" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_JardianceMember" xlink:label="loc_lly_JardianceMember_B77643B4D6B479B51FFDF5374AC6C2C1" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lly_BoerhringerIngelheimBiMember_97BBCB7BE8621A4D93B5F5374AC66F37" xlink:to="loc_lly_JardianceMember_B77643B4D6B479B51FFDF5374AC6C2C1" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_LlyCompoundsMember" xlink:label="loc_lly_LlyCompoundsMember_5CF2AFE80BFAF6A1F530F5374AC6D4E8" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lly_BoerhringerIngelheimBiMember_97BBCB7BE8621A4D93B5F5374AC66F37" xlink:to="loc_lly_LlyCompoundsMember_5CF2AFE80BFAF6A1F530F5374AC6D4E8" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_LlyOptionalCompoundMember" xlink:label="loc_lly_LlyOptionalCompoundMember_913B8D860787F4332A17F5374AC643B8" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lly_BoerhringerIngelheimBiMember_97BBCB7BE8621A4D93B5F5374AC66F37" xlink:to="loc_lly_LlyOptionalCompoundMember_913B8D860787F4332A17F5374AC643B8" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_BaricitinibMember" xlink:label="loc_lly_BaricitinibMember_63A1C9DDC0DE92FAA8F0F5374AC6440F" xlink:type="locator" />
    <presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ProductsAndServicesDomain_59838AAD98689BE57045F5374AC648EA" xlink:to="loc_lly_BaricitinibMember_63A1C9DDC0DE92FAA8F0F5374AC6440F" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_TanezumabMember" xlink:label="loc_lly_TanezumabMember_F44F04328E1A0C3B4209F5374AC62337" xlink:type="locator" />
    <presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ProductsAndServicesDomain_59838AAD98689BE57045F5374AC648EA" xlink:to="loc_lly_TanezumabMember_F44F04328E1A0C3B4209F5374AC62337" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_SubsequentEventTypeAxis" xlink:label="loc_us-gaap_SubsequentEventTypeAxis_AF6585684C19D68EBE2CF5374AC6B328" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_C3A0D09B304D9B20A64DF5374AC40815" xlink:to="loc_us-gaap_SubsequentEventTypeAxis_AF6585684C19D68EBE2CF5374AC6B328" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_SubsequentEventTypeDomain" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_1EE2DAB9188AE0EFCB19F5374AC7197B" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_AF6585684C19D68EBE2CF5374AC6B328" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_1EE2DAB9188AE0EFCB19F5374AC7197B" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_SubsequentEventMember" xlink:label="loc_us-gaap_SubsequentEventMember_4A8BDF3D65D20DDB18B6F5374AC77E42" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventTypeDomain_1EE2DAB9188AE0EFCB19F5374AC7197B" xlink:to="loc_us-gaap_SubsequentEventMember_4A8BDF3D65D20DDB18B6F5374AC77E42" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_AA70F828C335AA94402CF5374AC74E8C" xlink:type="locator" />
    <presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_C3A0D09B304D9B20A64DF5374AC40815" xlink:to="loc_us-gaap_StatementLineItems_AA70F828C335AA94402CF5374AC74E8C" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_BusinessAcquisitionsProFormaRevenue" xlink:label="loc_us-gaap_BusinessAcquisitionsProFormaRevenue_4BCADF50A20A203B8F82F5374AC7EA60" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_AA70F828C335AA94402CF5374AC74E8C" xlink:to="loc_us-gaap_BusinessAcquisitionsProFormaRevenue_4BCADF50A20A203B8F82F5374AC7EA60" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles_824AE07066C4A267FD1EF5374AC7DD49" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_AA70F828C335AA94402CF5374AC74E8C" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles_824AE07066C4A267FD1EF5374AC7DD49" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_SalesRevenueGoodsNet" xlink:label="loc_us-gaap_SalesRevenueGoodsNet_AC0F41365F3F9BAD275BF5374AC781D4" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_AA70F828C335AA94402CF5374AC74E8C" xlink:to="loc_us-gaap_SalesRevenueGoodsNet_AC0F41365F3F9BAD275BF5374AC781D4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OtherSalesRevenueNet" xlink:label="loc_us-gaap_OtherSalesRevenueNet_C98282DCB44D88C9EFC4F5374AC771E3" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_AA70F828C335AA94402CF5374AC74E8C" xlink:to="loc_us-gaap_OtherSalesRevenueNet_C98282DCB44D88C9EFC4F5374AC771E3" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_Revenues" xlink:label="loc_us-gaap_Revenues_4C3DB18239F59AD034FBF5374AC76C75" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_AA70F828C335AA94402CF5374AC74E8C" xlink:to="loc_us-gaap_Revenues_4C3DB18239F59AD034FBF5374AC76C75" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OtherNonoperatingIncomeExpense" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_8CB3CBB141B15DECA043F5374AC74DDB" xlink:type="locator" />
    <presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_AA70F828C335AA94402CF5374AC74E8C" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpense_8CB3CBB141B15DECA043F5374AC74DDB" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ResearchAndDevelopmentExpense" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_4526A866FE50B09E2EA3F5374AC785FB" xlink:type="locator" />
    <presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_AA70F828C335AA94402CF5374AC74E8C" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_4526A866FE50B09E2EA3F5374AC785FB" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_CollaborativeArrangementRightsAndObligationsTerms" xlink:label="loc_lly_CollaborativeArrangementRightsAndObligationsTerms_143D294B616C104A4C78F5374AC7A80D" xlink:type="locator" />
    <presentationArc order="8" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_AA70F828C335AA94402CF5374AC74E8C" xlink:to="loc_lly_CollaborativeArrangementRightsAndObligationsTerms_143D294B616C104A4C78F5374AC7A80D" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_NonoperatingIncomeExpense" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_818CC1ABF841D505D275F5374AC70610" xlink:type="locator" />
    <presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_AA70F828C335AA94402CF5374AC74E8C" xlink:to="loc_us-gaap_NonoperatingIncomeExpense_818CC1ABF841D505D275F5374AC70610" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_SellingGeneralAndAdministrativeExpense" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpense_6CC7E37D669D0BC0DC96F5374AC71C44" xlink:type="locator" />
    <presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_AA70F828C335AA94402CF5374AC74E8C" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpense_6CC7E37D669D0BC0DC96F5374AC71C44" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_CollaborativeArrangementRightsAndObligationsPercent" xlink:label="loc_lly_CollaborativeArrangementRightsAndObligationsPercent_6657C7265C7B20680321F5374AC797C5" xlink:type="locator" />
    <presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_AA70F828C335AA94402CF5374AC74E8C" xlink:to="loc_lly_CollaborativeArrangementRightsAndObligationsPercent_6657C7265C7B20680321F5374AC797C5" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DebtInstrumentInterestRateStatedPercentage" xlink:label="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_C59107EBC7A567A10220F5374AC72BAB" xlink:type="locator" />
    <presentationArc order="12" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_AA70F828C335AA94402CF5374AC74E8C" xlink:to="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_C59107EBC7A567A10220F5374AC72BAB" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_CollaborativeArrangementRightsAndObligationsTermsOfArrangementPeriod" xlink:label="loc_lly_CollaborativeArrangementRightsAndObligationsTermsOfArrangementPeriod_799BEAF2F5406D57C724F5374AC7E1D7" xlink:type="locator" />
    <presentationArc order="13" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_AA70F828C335AA94402CF5374AC74E8C" xlink:to="loc_lly_CollaborativeArrangementRightsAndObligationsTermsOfArrangementPeriod_799BEAF2F5406D57C724F5374AC7E1D7" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_AcquiredInProcessResearchAndDevelopment" xlink:label="loc_lly_AcquiredInProcessResearchAndDevelopment_C85D55BE979107FAA904F5374AC7CCCF" xlink:type="locator" />
    <presentationArc order="14" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_AA70F828C335AA94402CF5374AC74E8C" xlink:to="loc_lly_AcquiredInProcessResearchAndDevelopment_C85D55BE979107FAA904F5374AC7CCCF" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AmortizationOfIntangibleAssets" xlink:label="loc_us-gaap_AmortizationOfIntangibleAssets_F208C3A8C78EA71F1668F5374AC74135" xlink:type="locator" />
    <presentationArc order="15" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_AA70F828C335AA94402CF5374AC74E8C" xlink:to="loc_us-gaap_AmortizationOfIntangibleAssets_F208C3A8C78EA71F1668F5374AC74135" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxAssetsNoncurrent" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxAssetsNoncurrent_1699296B83996D87CA1BF5374AC8D258" xlink:type="locator" />
    <presentationArc order="16" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_AA70F828C335AA94402CF5374AC74E8C" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxAssetsNoncurrent_1699296B83996D87CA1BF5374AC8D258" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxLiabilitiesNoncurrent" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxLiabilitiesNoncurrent_F41FECD194E0F87D338AF5374AC8B30A" xlink:type="locator" />
    <presentationArc order="17" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_AA70F828C335AA94402CF5374AC74E8C" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxLiabilitiesNoncurrent_F41FECD194E0F87D338AF5374AC8B30A" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssets" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssets_B1C06802CF888E9054C7F5374AC89A77" xlink:type="locator" />
    <presentationArc order="18" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_AA70F828C335AA94402CF5374AC74E8C" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssets_B1C06802CF888E9054C7F5374AC89A77" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_90EE9626D315DAE5D177F5374AC84287" xlink:type="locator" />
    <presentationArc order="19" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_AA70F828C335AA94402CF5374AC74E8C" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_90EE9626D315DAE5D177F5374AC84287" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_BusinessCombinationContingentConsiderationLiability" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationLiability_3B9DA55CE85DE57D7AACF5374AC8110B" xlink:type="locator" />
    <presentationArc order="20" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_AA70F828C335AA94402CF5374AC74E8C" xlink:to="loc_us-gaap_BusinessCombinationContingentConsiderationLiability_3B9DA55CE85DE57D7AACF5374AC8110B" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.lilly.com/role/CollaborationsTables" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract" xlink:label="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_3996C1151BA630106B53D0F718E4F04E" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable" xlink:label="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_82AB6013803649F97F8FD0F718E49AEB" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_3996C1151BA630106B53D0F718E4F04E" xlink:to="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_82AB6013803649F97F8FD0F718E49AEB" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_TypeOfArrangementAxis" xlink:label="loc_us-gaap_TypeOfArrangementAxis_5B04F739E150ABC37AE5D0F718E44141" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_82AB6013803649F97F8FD0F718E49AEB" xlink:to="loc_us-gaap_TypeOfArrangementAxis_5B04F739E150ABC37AE5D0F718E44141" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_3D8E9B7A066ED27855F4D0F718EA1D3C" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TypeOfArrangementAxis_5B04F739E150ABC37AE5D0F718E44141" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_3D8E9B7A066ED27855F4D0F718EA1D3C" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_SellingGeneralAndAdministrativeExpensesMember" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpensesMember_0035CDB1F427C2A0D72ED0F718EA488F" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_3D8E9B7A066ED27855F4D0F718EA1D3C" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpensesMember_0035CDB1F427C2A0D72ED0F718EA488F" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CollaborativeArrangementMember" xlink:label="loc_us-gaap_CollaborativeArrangementMember_7B91B54A403FCA1B46A7D0F718EA6A9B" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_3D8E9B7A066ED27855F4D0F718EA1D3C" xlink:to="loc_us-gaap_CollaborativeArrangementMember_7B91B54A403FCA1B46A7D0F718EA6A9B" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ProductOrServiceAxis" xlink:label="loc_us-gaap_ProductOrServiceAxis_65E020F4BCD0A4AAC307D0F718EAC6BA" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_82AB6013803649F97F8FD0F718E49AEB" xlink:to="loc_us-gaap_ProductOrServiceAxis_65E020F4BCD0A4AAC307D0F718EAC6BA" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ProductsAndServicesDomain" xlink:label="loc_us-gaap_ProductsAndServicesDomain_F993223FF2D30EC239D0D0F718EA642C" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ProductOrServiceAxis_65E020F4BCD0A4AAC307D0F718EAC6BA" xlink:to="loc_us-gaap_ProductsAndServicesDomain_F993223FF2D30EC239D0D0F718EA642C" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_TrajentaBIMember" xlink:label="loc_lly_TrajentaBIMember_310C33AAE7FB41BCB244D0F718EA5C92" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ProductsAndServicesDomain_F993223FF2D30EC239D0D0F718EA642C" xlink:to="loc_lly_TrajentaBIMember_310C33AAE7FB41BCB244D0F718EA5C92" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_DiabetesCollaborationMember" xlink:label="loc_lly_DiabetesCollaborationMember_5ECB5AF02EF51295B419D0F718EA61B2" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ProductsAndServicesDomain_F993223FF2D30EC239D0D0F718EA642C" xlink:to="loc_lly_DiabetesCollaborationMember_5ECB5AF02EF51295B419D0F718EA61B2" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_ErbituxMember" xlink:label="loc_lly_ErbituxMember_C9C17CFC79407DF8E925D0F718EA1D0B" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ProductsAndServicesDomain_F993223FF2D30EC239D0D0F718EA642C" xlink:to="loc_lly_ErbituxMember_C9C17CFC79407DF8E925D0F718EA1D0B" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_ExenatideMember" xlink:label="loc_lly_ExenatideMember_964107F515BD447EE1A5D0F718EA1DE6" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ProductsAndServicesDomain_F993223FF2D30EC239D0D0F718EA642C" xlink:to="loc_lly_ExenatideMember_964107F515BD447EE1A5D0F718EA1DE6" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_EffientMember" xlink:label="loc_lly_EffientMember_E38545592709DCD0BD45D0F718EB947F" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ProductsAndServicesDomain_F993223FF2D30EC239D0D0F718EA642C" xlink:to="loc_lly_EffientMember_E38545592709DCD0BD45D0F718EB947F" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_BusinessAcquisitionAxis" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_A7495F397565D229A36FD0FEC83CDE2E" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_82AB6013803649F97F8FD0F718E49AEB" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_A7495F397565D229A36FD0FEC83CDE2E" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_F5D4A2AA4E87128754C5D0FEC83C37BD" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_A7495F397565D229A36FD0FEC83CDE2E" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_F5D4A2AA4E87128754C5D0FEC83C37BD" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_ErbituxAcquisitionMember" xlink:label="loc_lly_ErbituxAcquisitionMember_D2A9653FF8565EF1EEA7D0F718E4DCF1" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_F5D4A2AA4E87128754C5D0FEC83C37BD" xlink:to="loc_lly_ErbituxAcquisitionMember_D2A9653FF8565EF1EEA7D0F718E4DCF1" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_A57B3D9CD4AE6DA919F3D0F718EB0A2E" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_82AB6013803649F97F8FD0F718E49AEB" xlink:to="loc_us-gaap_StatementLineItems_A57B3D9CD4AE6DA919F3D0F718EB0A2E" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScheduleOfRecognizedIdentifiedAssetsAcquiredAndLiabilitiesAssumedTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfRecognizedIdentifiedAssetsAcquiredAndLiabilitiesAssumedTableTextBlock_453047F623F78A31950BD17925FF45C1" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_A57B3D9CD4AE6DA919F3D0F718EB0A2E" xlink:to="loc_us-gaap_ScheduleOfRecognizedIdentifiedAssetsAcquiredAndLiabilitiesAssumedTableTextBlock_453047F623F78A31950BD17925FF45C1" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTableTextBlock_5EDC0616EE335A0936D3D0F718EB7213" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_A57B3D9CD4AE6DA919F3D0F718EB0A2E" xlink:to="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTableTextBlock_5EDC0616EE335A0936D3D0F718EB7213" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.lilly.com/role/ConsolidatedBalanceSheets" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StatementOfFinancialPositionAbstract" xlink:label="loc_us-gaap_StatementOfFinancialPositionAbstract_CF8CA83276097BEED610F5374B15A224" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StatementTable" xlink:label="loc_us-gaap_StatementTable_A4E52AC7B25187A85C27F5374B15D901" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_CF8CA83276097BEED610F5374B15A224" xlink:to="loc_us-gaap_StatementTable_A4E52AC7B25187A85C27F5374B15D901" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StatementScenarioAxis" xlink:label="loc_us-gaap_StatementScenarioAxis_2832716ACB8989D85A88F5374B158897" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_A4E52AC7B25187A85C27F5374B15D901" xlink:to="loc_us-gaap_StatementScenarioAxis_2832716ACB8989D85A88F5374B158897" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScenarioUnspecifiedDomain" xlink:label="loc_us-gaap_ScenarioUnspecifiedDomain_AB373FBCE215D770D944F5374B159B0E" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementScenarioAxis_2832716ACB8989D85A88F5374B158897" xlink:to="loc_us-gaap_ScenarioUnspecifiedDomain_AB373FBCE215D770D944F5374B159B0E" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StatementClassOfStockAxis" xlink:label="loc_us-gaap_StatementClassOfStockAxis_171B5FE7E8250170A8F6F5374B15C07D" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_A4E52AC7B25187A85C27F5374B15D901" xlink:to="loc_us-gaap_StatementClassOfStockAxis_171B5FE7E8250170A8F6F5374B15C07D" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ClassOfStockDomain" xlink:label="loc_us-gaap_ClassOfStockDomain_A8830F2281BC940E246EF5374B152CDF" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementClassOfStockAxis_171B5FE7E8250170A8F6F5374B15C07D" xlink:to="loc_us-gaap_ClassOfStockDomain_A8830F2281BC940E246EF5374B152CDF" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_324B36F9BC74AC69B5F8F5374B1582C3" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_A4E52AC7B25187A85C27F5374B15D901" xlink:to="loc_us-gaap_StatementLineItems_324B36F9BC74AC69B5F8F5374B1582C3" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AssetsAbstract" xlink:label="loc_us-gaap_AssetsAbstract_6996C60701181B273A16F5374B153119" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_324B36F9BC74AC69B5F8F5374B1582C3" xlink:to="loc_us-gaap_AssetsAbstract_6996C60701181B273A16F5374B153119" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AssetsCurrentAbstract" xlink:label="loc_us-gaap_AssetsCurrentAbstract_0A181673233FC773D331F5374B166839" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_6996C60701181B273A16F5374B153119" xlink:to="loc_us-gaap_AssetsCurrentAbstract_0A181673233FC773D331F5374B166839" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_2D449A9C3321EEA19035F5374B16CAAB" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_0A181673233FC773D331F5374B166839" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_2D449A9C3321EEA19035F5374B16CAAB" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ShortTermInvestments" xlink:label="loc_us-gaap_ShortTermInvestments_D5F26E70F6CFB067E783F5374B163B99" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_0A181673233FC773D331F5374B166839" xlink:to="loc_us-gaap_ShortTermInvestments_D5F26E70F6CFB067E783F5374B163B99" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AccountsReceivableNetCurrent" xlink:label="loc_us-gaap_AccountsReceivableNetCurrent_0829333FCF81D958CB5DF5374B16151D" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_0A181673233FC773D331F5374B166839" xlink:to="loc_us-gaap_AccountsReceivableNetCurrent_0829333FCF81D958CB5DF5374B16151D" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AccountsAndOtherReceivablesNetCurrent" xlink:label="loc_us-gaap_AccountsAndOtherReceivablesNetCurrent_9D16292FC3AB89D5A267F5374B16BACB" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_0A181673233FC773D331F5374B166839" xlink:to="loc_us-gaap_AccountsAndOtherReceivablesNetCurrent_9D16292FC3AB89D5A267F5374B16BACB" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_InventoryNet" xlink:label="loc_us-gaap_InventoryNet_7FF407DD9657F1ED2909F5374B16F4F4" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_0A181673233FC773D331F5374B166839" xlink:to="loc_us-gaap_InventoryNet_7FF407DD9657F1ED2909F5374B16F4F4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PrepaidExpenseCurrent" xlink:label="loc_us-gaap_PrepaidExpenseCurrent_D9D46A9402AFE3F24367F5374B1655B5" xlink:type="locator" />
    <presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_0A181673233FC773D331F5374B166839" xlink:to="loc_us-gaap_PrepaidExpenseCurrent_D9D46A9402AFE3F24367F5374B1655B5" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AssetsCurrent" xlink:label="loc_us-gaap_AssetsCurrent_4B492E7D3DC1002B79E5F5374B168CDD" xlink:type="locator" />
    <presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_0A181673233FC773D331F5374B166839" xlink:to="loc_us-gaap_AssetsCurrent_4B492E7D3DC1002B79E5F5374B168CDD" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AssetsNoncurrentAbstract" xlink:label="loc_us-gaap_AssetsNoncurrentAbstract_A5221769F04BACB7584CF5374B162C39" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_6996C60701181B273A16F5374B153119" xlink:to="loc_us-gaap_AssetsNoncurrentAbstract_A5221769F04BACB7584CF5374B162C39" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_RestrictedCashAndCashEquivalentsNoncurrent" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalentsNoncurrent_AB2521A6409B67F48225F5374B164782" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsNoncurrentAbstract_A5221769F04BACB7584CF5374B162C39" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalentsNoncurrent_AB2521A6409B67F48225F5374B164782" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_LongTermInvestments" xlink:label="loc_us-gaap_LongTermInvestments_80460F9D4D3942CB49DDF5374B16CE49" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsNoncurrentAbstract_A5221769F04BACB7584CF5374B162C39" xlink:to="loc_us-gaap_LongTermInvestments_80460F9D4D3942CB49DDF5374B16CE49" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_Goodwill" xlink:label="loc_us-gaap_Goodwill_EF8AD5964591EF4A41FDF5374B16402C" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsNoncurrentAbstract_A5221769F04BACB7584CF5374B162C39" xlink:to="loc_us-gaap_Goodwill_EF8AD5964591EF4A41FDF5374B16402C" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_IntangibleAssetsNetExcludingGoodwill" xlink:label="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_E4355C79DC1A7EA04CFDF5374B16E2F6" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsNoncurrentAbstract_A5221769F04BACB7584CF5374B162C39" xlink:to="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_E4355C79DC1A7EA04CFDF5374B16E2F6" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OtherAssetsNoncurrent" xlink:label="loc_us-gaap_OtherAssetsNoncurrent_FED85EED7B88CEE57F48F5374B16AE6A" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsNoncurrentAbstract_A5221769F04BACB7584CF5374B162C39" xlink:to="loc_us-gaap_OtherAssetsNoncurrent_FED85EED7B88CEE57F48F5374B16AE6A" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AssetsNoncurrent" xlink:label="loc_us-gaap_AssetsNoncurrent_E3E220EF7FDCD4784DE3F5374B163331" xlink:type="locator" />
    <presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsNoncurrentAbstract_A5221769F04BACB7584CF5374B162C39" xlink:to="loc_us-gaap_AssetsNoncurrent_E3E220EF7FDCD4784DE3F5374B163331" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PropertyPlantAndEquipmentNet" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_26A82F68BFF150A58327F5374B163AAA" xlink:type="locator" />
    <presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsNoncurrentAbstract_A5221769F04BACB7584CF5374B162C39" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_26A82F68BFF150A58327F5374B163AAA" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_Assets" xlink:label="loc_us-gaap_Assets_3F1064C298E4DB11B5AFF5374B164922" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_6996C60701181B273A16F5374B153119" xlink:to="loc_us-gaap_Assets_3F1064C298E4DB11B5AFF5374B164922" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_LiabilitiesAndStockholdersEquityAbstract" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_E682A52A5B1ED99C9296F5374B17DE20" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_324B36F9BC74AC69B5F8F5374B1582C3" xlink:to="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_E682A52A5B1ED99C9296F5374B17DE20" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_LiabilitiesCurrentAbstract" xlink:label="loc_us-gaap_LiabilitiesCurrentAbstract_D5F73120236FBF108797F5374B17617A" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_E682A52A5B1ED99C9296F5374B17DE20" xlink:to="loc_us-gaap_LiabilitiesCurrentAbstract_D5F73120236FBF108797F5374B17617A" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DebtCurrent" xlink:label="loc_us-gaap_DebtCurrent_46249554F035080D9104F5374B176DED" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_D5F73120236FBF108797F5374B17617A" xlink:to="loc_us-gaap_DebtCurrent_46249554F035080D9104F5374B176DED" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AccountsPayableCurrent" xlink:label="loc_us-gaap_AccountsPayableCurrent_33B9A0D604EEA64FA357F5374B17916D" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_D5F73120236FBF108797F5374B17617A" xlink:to="loc_us-gaap_AccountsPayableCurrent_33B9A0D604EEA64FA357F5374B17916D" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_EmployeeRelatedLiabilitiesCurrent" xlink:label="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_5D0E1AA7F84A43C3DE71F5374B17CD00" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_D5F73120236FBF108797F5374B17617A" xlink:to="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_5D0E1AA7F84A43C3DE71F5374B17CD00" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_SalesRebatesAndDiscounts" xlink:label="loc_lly_SalesRebatesAndDiscounts_10A4E11AB5E637C97084F5374B1741E6" xlink:type="locator" />
    <presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_D5F73120236FBF108797F5374B17617A" xlink:to="loc_lly_SalesRebatesAndDiscounts_10A4E11AB5E637C97084F5374B1741E6" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DividendsPayableCurrent" xlink:label="loc_us-gaap_DividendsPayableCurrent_53A8133E2E4344E967E8F5374B17D7F4" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_D5F73120236FBF108797F5374B17617A" xlink:to="loc_us-gaap_DividendsPayableCurrent_53A8133E2E4344E967E8F5374B17D7F4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_TaxesPayableCurrent" xlink:label="loc_us-gaap_TaxesPayableCurrent_33950B22900F0D07D5A1F5374B17CD13" xlink:type="locator" />
    <presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_D5F73120236FBF108797F5374B17617A" xlink:to="loc_us-gaap_TaxesPayableCurrent_33950B22900F0D07D5A1F5374B17CD13" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OtherLiabilitiesCurrent" xlink:label="loc_us-gaap_OtherLiabilitiesCurrent_C484B626C244FED9E4A8F5374B17DD42" xlink:type="locator" />
    <presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_D5F73120236FBF108797F5374B17617A" xlink:to="loc_us-gaap_OtherLiabilitiesCurrent_C484B626C244FED9E4A8F5374B17DD42" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_LiabilitiesCurrent" xlink:label="loc_us-gaap_LiabilitiesCurrent_DB856D5425748C2304DAF5374B172118" xlink:type="locator" />
    <presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_D5F73120236FBF108797F5374B17617A" xlink:to="loc_us-gaap_LiabilitiesCurrent_DB856D5425748C2304DAF5374B172118" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_LiabilitiesNoncurrentAbstract" xlink:label="loc_us-gaap_LiabilitiesNoncurrentAbstract_4D364C7CE5ACF01573DCF5374B1700A3" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_E682A52A5B1ED99C9296F5374B17DE20" xlink:to="loc_us-gaap_LiabilitiesNoncurrentAbstract_4D364C7CE5ACF01573DCF5374B1700A3" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_LongTermDebtNoncurrent" xlink:label="loc_us-gaap_LongTermDebtNoncurrent_27E057600B0F25623D57F5374B1759D7" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesNoncurrentAbstract_4D364C7CE5ACF01573DCF5374B1700A3" xlink:to="loc_us-gaap_LongTermDebtNoncurrent_27E057600B0F25623D57F5374B1759D7" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PensionAndOtherPostretirementDefinedBenefitPlansLiabilitiesNoncurrent" xlink:label="loc_us-gaap_PensionAndOtherPostretirementDefinedBenefitPlansLiabilitiesNoncurrent_E12F4E171270D8425AC6F5374B170B5C" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesNoncurrentAbstract_4D364C7CE5ACF01573DCF5374B1700A3" xlink:to="loc_us-gaap_PensionAndOtherPostretirementDefinedBenefitPlansLiabilitiesNoncurrent_E12F4E171270D8425AC6F5374B170B5C" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AccruedIncomeTaxesNoncurrent" xlink:label="loc_us-gaap_AccruedIncomeTaxesNoncurrent_92B55CEE3170C7E60E1BF5374B1705DC" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesNoncurrentAbstract_4D364C7CE5ACF01573DCF5374B1700A3" xlink:to="loc_us-gaap_AccruedIncomeTaxesNoncurrent_92B55CEE3170C7E60E1BF5374B1705DC" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OtherLiabilitiesNoncurrent" xlink:label="loc_us-gaap_OtherLiabilitiesNoncurrent_3AB77F60BB5F290A84ACF5374B177A85" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesNoncurrentAbstract_4D364C7CE5ACF01573DCF5374B1700A3" xlink:to="loc_us-gaap_OtherLiabilitiesNoncurrent_3AB77F60BB5F290A84ACF5374B177A85" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_LiabilitiesNoncurrent" xlink:label="loc_us-gaap_LiabilitiesNoncurrent_C33B4A13D9CD62DBEA62F5374B174AF5" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesNoncurrentAbstract_4D364C7CE5ACF01573DCF5374B1700A3" xlink:to="loc_us-gaap_LiabilitiesNoncurrent_C33B4A13D9CD62DBEA62F5374B174AF5" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterestAbstract" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterestAbstract_99F4B7BD42BC426537F7F5374B185484" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_E682A52A5B1ED99C9296F5374B17DE20" xlink:to="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterestAbstract_99F4B7BD42BC426537F7F5374B185484" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CommonStockValue" xlink:label="loc_us-gaap_CommonStockValue_8F84EA62E15223CBB634F5374B186E2E" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterestAbstract_99F4B7BD42BC426537F7F5374B185484" xlink:to="loc_us-gaap_CommonStockValue_8F84EA62E15223CBB634F5374B186E2E" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AdditionalPaidInCapitalCommonStock" xlink:label="loc_us-gaap_AdditionalPaidInCapitalCommonStock_50C61B0BFB1A741F383FF5374B1888D5" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterestAbstract_99F4B7BD42BC426537F7F5374B185484" xlink:to="loc_us-gaap_AdditionalPaidInCapitalCommonStock_50C61B0BFB1A741F383FF5374B1888D5" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_RetainedEarningsAccumulatedDeficit" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_4C254F3EFEA0445D0691F5374B1860B6" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterestAbstract_99F4B7BD42BC426537F7F5374B185484" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_4C254F3EFEA0445D0691F5374B1860B6" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CommonStockSharesHeldInEmployeeTrust" xlink:label="loc_us-gaap_CommonStockSharesHeldInEmployeeTrust_E361CF027FC3A4695F08F5374B18B2C1" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterestAbstract_99F4B7BD42BC426537F7F5374B185484" xlink:to="loc_us-gaap_CommonStockSharesHeldInEmployeeTrust_E361CF027FC3A4695F08F5374B18B2C1" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_D6C20D972727136E42F0F5374B18985F" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterestAbstract_99F4B7BD42BC426537F7F5374B185484" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_D6C20D972727136E42F0F5374B18985F" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_TreasuryStockValue" xlink:label="loc_us-gaap_TreasuryStockValue_5BAFD25CD63EF7FCE03FF5374B18D9D2" xlink:type="locator" />
    <presentationArc order="6" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterestAbstract_99F4B7BD42BC426537F7F5374B185484" xlink:to="loc_us-gaap_TreasuryStockValue_5BAFD25CD63EF7FCE03FF5374B18D9D2" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StockholdersEquity" xlink:label="loc_us-gaap_StockholdersEquity_AA74207F6DCD15BA4192F5374B1862F5" xlink:type="locator" />
    <presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterestAbstract_99F4B7BD42BC426537F7F5374B185484" xlink:to="loc_us-gaap_StockholdersEquity_AA74207F6DCD15BA4192F5374B1862F5" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_MinorityInterest" xlink:label="loc_us-gaap_MinorityInterest_96D0B449C255521945B0F5374B188B53" xlink:type="locator" />
    <presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterestAbstract_99F4B7BD42BC426537F7F5374B185484" xlink:to="loc_us-gaap_MinorityInterest_96D0B449C255521945B0F5374B188B53" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_B9D12E1BD09B42FA1114F5374B188160" xlink:type="locator" />
    <presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterestAbstract_99F4B7BD42BC426537F7F5374B185484" xlink:to="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_B9D12E1BD09B42FA1114F5374B188160" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_LiabilitiesAndStockholdersEquity" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_7AC6ABCA0F91C4CAC5ABF5374B1846C9" xlink:type="locator" />
    <presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterestAbstract_99F4B7BD42BC426537F7F5374B185484" xlink:to="loc_us-gaap_LiabilitiesAndStockholdersEquity_7AC6ABCA0F91C4CAC5ABF5374B1846C9" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.lilly.com/role/ConsolidatedBalanceSheetsParenthetical" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StatementOfFinancialPositionAbstract" xlink:label="loc_us-gaap_StatementOfFinancialPositionAbstract_BC573E735898D9E49371FC036EC554FC" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StatementTable" xlink:label="loc_us-gaap_StatementTable_63178BF6F2E8AF38EA7CFC036EC5CD69" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_BC573E735898D9E49371FC036EC554FC" xlink:to="loc_us-gaap_StatementTable_63178BF6F2E8AF38EA7CFC036EC5CD69" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StatementScenarioAxis" xlink:label="loc_us-gaap_StatementScenarioAxis_323AF5E19EC41205B4A1FC036EC58767" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_63178BF6F2E8AF38EA7CFC036EC5CD69" xlink:to="loc_us-gaap_StatementScenarioAxis_323AF5E19EC41205B4A1FC036EC58767" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScenarioUnspecifiedDomain" xlink:label="loc_us-gaap_ScenarioUnspecifiedDomain_B84F32CCC5939AB73F26FC036EC5BB8D" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementScenarioAxis_323AF5E19EC41205B4A1FC036EC58767" xlink:to="loc_us-gaap_ScenarioUnspecifiedDomain_B84F32CCC5939AB73F26FC036EC5BB8D" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StatementClassOfStockAxis" xlink:label="loc_us-gaap_StatementClassOfStockAxis_324991C8D064A5588D64FC036EC57895" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_63178BF6F2E8AF38EA7CFC036EC5CD69" xlink:to="loc_us-gaap_StatementClassOfStockAxis_324991C8D064A5588D64FC036EC57895" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ClassOfStockDomain" xlink:label="loc_us-gaap_ClassOfStockDomain_5F4DBF443581ED022BA4FC036EC5718A" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementClassOfStockAxis_324991C8D064A5588D64FC036EC57895" xlink:to="loc_us-gaap_ClassOfStockDomain_5F4DBF443581ED022BA4FC036EC5718A" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_8547BEA41784B53FA240FC036EC59757" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_63178BF6F2E8AF38EA7CFC036EC5CD69" xlink:to="loc_us-gaap_StatementLineItems_8547BEA41784B53FA240FC036EC59757" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent" xlink:label="loc_us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent_7F17841BA13B6DD9E8C0FC036EC5C394" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_8547BEA41784B53FA240FC036EC59757" xlink:to="loc_us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent_7F17841BA13B6DD9E8C0FC036EC5C394" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CommonStockSharesIssued" xlink:label="loc_us-gaap_CommonStockSharesIssued_1A8FDA2B53FF1A93F9F6FC036EC5BAE5" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_8547BEA41784B53FA240FC036EC59757" xlink:to="loc_us-gaap_CommonStockSharesIssued_1A8FDA2B53FF1A93F9F6FC036EC5BAE5" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_TreasuryStockShares" xlink:label="loc_us-gaap_TreasuryStockShares_C8F0FD22C5C7D37278C7FC036EC5D55F" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_8547BEA41784B53FA240FC036EC59757" xlink:to="loc_us-gaap_TreasuryStockShares_C8F0FD22C5C7D37278C7FC036EC5D55F" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.lilly.com/role/ConsolidatedStatementsOfCashFlows" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StatementOfCashFlowsAbstract" xlink:label="loc_us-gaap_StatementOfCashFlowsAbstract_9D9EC889762A07CF9DFFF68085190E98" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StatementTable" xlink:label="loc_us-gaap_StatementTable_BA2A75BDF27F18CB7F66F68085193DE5" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_9D9EC889762A07CF9DFFF68085190E98" xlink:to="loc_us-gaap_StatementTable_BA2A75BDF27F18CB7F66F68085193DE5" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StatementScenarioAxis" xlink:label="loc_us-gaap_StatementScenarioAxis_5FBA6ECC1EC56FCD803BF6808519B21C" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_BA2A75BDF27F18CB7F66F68085193DE5" xlink:to="loc_us-gaap_StatementScenarioAxis_5FBA6ECC1EC56FCD803BF6808519B21C" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScenarioUnspecifiedDomain" xlink:label="loc_us-gaap_ScenarioUnspecifiedDomain_2F9C9B17967A710C78D2F68085193865" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementScenarioAxis_5FBA6ECC1EC56FCD803BF6808519B21C" xlink:to="loc_us-gaap_ScenarioUnspecifiedDomain_2F9C9B17967A710C78D2F68085193865" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_D6E537F785ECEAEC1212F680851979F5" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_BA2A75BDF27F18CB7F66F68085193DE5" xlink:to="loc_us-gaap_StatementLineItems_D6E537F785ECEAEC1212F680851979F5" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CashAndCashEquivalentsPeriodIncreaseDecreaseAbstract" xlink:label="loc_us-gaap_CashAndCashEquivalentsPeriodIncreaseDecreaseAbstract_95735B05F3FC0461A9ECF6808519275E" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_D6E537F785ECEAEC1212F680851979F5" xlink:to="loc_us-gaap_CashAndCashEquivalentsPeriodIncreaseDecreaseAbstract_95735B05F3FC0461A9ECF6808519275E" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_3C2340C1C2FA378E6B39F6808519CF1D" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CashAndCashEquivalentsPeriodIncreaseDecreaseAbstract_95735B05F3FC0461A9ECF6808519275E" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_3C2340C1C2FA378E6B39F6808519CF1D" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperationsAbstract" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperationsAbstract_191325F5810956B07438F6808519734D" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_3C2340C1C2FA378E6B39F6808519CF1D" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperationsAbstract_191325F5810956B07438F6808519734D" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_NetIncomeLoss" xlink:label="loc_us-gaap_NetIncomeLoss_D0F0C725B5EC664C06D9F6808519BA41" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperationsAbstract_191325F5810956B07438F6808519734D" xlink:to="loc_us-gaap_NetIncomeLoss_D0F0C725B5EC664C06D9F6808519BA41" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract" xlink:label="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_D1E533DCB8F379F086C0F6808519F70D" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperationsAbstract_191325F5810956B07438F6808519734D" xlink:to="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_D1E533DCB8F379F086C0F6808519F70D" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DepreciationDepletionAndAmortization" xlink:label="loc_us-gaap_DepreciationDepletionAndAmortization_9DFE403FE631E8386B7BF68085199DF5" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_D1E533DCB8F379F086C0F6808519F70D" xlink:to="loc_us-gaap_DepreciationDepletionAndAmortization_9DFE403FE631E8386B7BF68085199DF5" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_IncreaseDecreaseInDeferredIncomeTaxes" xlink:label="loc_us-gaap_IncreaseDecreaseInDeferredIncomeTaxes_B49425C23CB61A659E7DF6808519491A" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_D1E533DCB8F379F086C0F6808519F70D" xlink:to="loc_us-gaap_IncreaseDecreaseInDeferredIncomeTaxes_B49425C23CB61A659E7DF6808519491A" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ShareBasedCompensation" xlink:label="loc_us-gaap_ShareBasedCompensation_A42C19B5F73591BC96E1F6808519BA17" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_D1E533DCB8F379F086C0F6808519F70D" xlink:to="loc_us-gaap_ShareBasedCompensation_A42C19B5F73591BC96E1F6808519BA17" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_AcquiredInProcessResearchAndDevelopment" xlink:label="loc_lly_AcquiredInProcessResearchAndDevelopment_869415F01D1FCB251D29F68085190830" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_D1E533DCB8F379F086C0F6808519F70D" xlink:to="loc_lly_AcquiredInProcessResearchAndDevelopment_869415F01D1FCB251D29F68085190830" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_GainLossOnContractTermination" xlink:label="loc_us-gaap_GainLossOnContractTermination_CF4A4F069AE88FE51AE8F68085191557" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_D1E533DCB8F379F086C0F6808519F70D" xlink:to="loc_us-gaap_GainLossOnContractTermination_CF4A4F069AE88FE51AE8F68085191557" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_PaymentsforProceedsfromHedgeOperatingActivities" xlink:label="loc_lly_PaymentsforProceedsfromHedgeOperatingActivities_664FDB492B18542A6AA2F6808519EFD6" xlink:type="locator" />
    <presentationArc order="6" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_D1E533DCB8F379F086C0F6808519F70D" xlink:to="loc_lly_PaymentsforProceedsfromHedgeOperatingActivities_664FDB492B18542A6AA2F6808519EFD6" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OtherOperatingActivitiesCashFlowStatement" xlink:label="loc_us-gaap_OtherOperatingActivitiesCashFlowStatement_CA1396A1934A65326A61F680851962CD" xlink:type="locator" />
    <presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_D1E533DCB8F379F086C0F6808519F70D" xlink:to="loc_us-gaap_OtherOperatingActivitiesCashFlowStatement_CA1396A1934A65326A61F680851962CD" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_IncreaseDecreaseInOperatingCapitalAbstract" xlink:label="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_0D13FC4FA5E340697843F6808519DCC7" xlink:type="locator" />
    <presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_D1E533DCB8F379F086C0F6808519F70D" xlink:to="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_0D13FC4FA5E340697843F6808519DCC7" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_IncreaseDecreaseInAccountsAndOtherReceivables" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsAndOtherReceivables_71BB1A04B84F586AC65BF680851973B1" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_0D13FC4FA5E340697843F6808519DCC7" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsAndOtherReceivables_71BB1A04B84F586AC65BF680851973B1" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_IncreaseDecreaseInInventories" xlink:label="loc_us-gaap_IncreaseDecreaseInInventories_80782C5BD76C2EB2F30EF680851936CE" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_0D13FC4FA5E340697843F6808519DCC7" xlink:to="loc_us-gaap_IncreaseDecreaseInInventories_80782C5BD76C2EB2F30EF680851936CE" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_IncreaseDecreaseInOtherOperatingAssets" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherOperatingAssets_4FF64B91FE59B727B18FF6808519225D" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_0D13FC4FA5E340697843F6808519DCC7" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherOperatingAssets_4FF64B91FE59B727B18FF6808519225D" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities_741C6680F77F17FD4852F68085192F39" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_0D13FC4FA5E340697843F6808519DCC7" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities_741C6680F77F17FD4852F68085192F39" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_BB7E808941DADE7E5894F68085192320" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_3C2340C1C2FA378E6B39F6808519CF1D" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_BB7E808941DADE7E5894F68085192320" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_3A9117F4253E1F3ADA87F680851930AC" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CashAndCashEquivalentsPeriodIncreaseDecreaseAbstract_95735B05F3FC0461A9ECF6808519275E" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_3A9117F4253E1F3ADA87F680851930AC" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperationsAbstract" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperationsAbstract_BD79CFA30A3B51E2B22BF6808519E4D2" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_3A9117F4253E1F3ADA87F680851930AC" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperationsAbstract_BD79CFA30A3B51E2B22BF6808519E4D2" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PaymentsToAcquireOtherPropertyPlantAndEquipment" xlink:label="loc_us-gaap_PaymentsToAcquireOtherPropertyPlantAndEquipment_88BA23D0788886149001F68085199282" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperationsAbstract_BD79CFA30A3B51E2B22BF6808519E4D2" xlink:to="loc_us-gaap_PaymentsToAcquireOtherPropertyPlantAndEquipment_88BA23D0788886149001F68085199282" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ProceedsFromSaleOfOtherPropertyPlantAndEquipment" xlink:label="loc_us-gaap_ProceedsFromSaleOfOtherPropertyPlantAndEquipment_7500CF68CAD11E193047F6808519E049" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperationsAbstract_BD79CFA30A3B51E2B22BF6808519E4D2" xlink:to="loc_us-gaap_ProceedsFromSaleOfOtherPropertyPlantAndEquipment_7500CF68CAD11E193047F6808519E049" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_IncreaseDecreaseInRestrictedCash" xlink:label="loc_us-gaap_IncreaseDecreaseInRestrictedCash_3DE9E1E4991EEE2B29C5F68085192458" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperationsAbstract_BD79CFA30A3B51E2B22BF6808519E4D2" xlink:to="loc_us-gaap_IncreaseDecreaseInRestrictedCash_3DE9E1E4991EEE2B29C5F68085192458" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ProceedsFromSaleOfShortTermInvestments" xlink:label="loc_us-gaap_ProceedsFromSaleOfShortTermInvestments_A1C0A360EC4E896DDA24F680851998AB" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperationsAbstract_BD79CFA30A3B51E2B22BF6808519E4D2" xlink:to="loc_us-gaap_ProceedsFromSaleOfShortTermInvestments_A1C0A360EC4E896DDA24F680851998AB" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PaymentsForProceedsFromShortTermInvestments" xlink:label="loc_us-gaap_PaymentsForProceedsFromShortTermInvestments_19530F0D43FD86EC6F85F6808519144D" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperationsAbstract_BD79CFA30A3B51E2B22BF6808519E4D2" xlink:to="loc_us-gaap_PaymentsForProceedsFromShortTermInvestments_19530F0D43FD86EC6F85F6808519144D" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ProceedsFromSaleAndMaturityOfOtherInvestments" xlink:label="loc_us-gaap_ProceedsFromSaleAndMaturityOfOtherInvestments_2CC458D161850FE9A5C9F6808519A9E6" xlink:type="locator" />
    <presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperationsAbstract_BD79CFA30A3B51E2B22BF6808519E4D2" xlink:to="loc_us-gaap_ProceedsFromSaleAndMaturityOfOtherInvestments_2CC458D161850FE9A5C9F6808519A9E6" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PaymentsToAcquireOtherInvestments" xlink:label="loc_us-gaap_PaymentsToAcquireOtherInvestments_C1DBF6CD150C1A994BBFF68085197430" xlink:type="locator" />
    <presentationArc order="7" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperationsAbstract_BD79CFA30A3B51E2B22BF6808519E4D2" xlink:to="loc_us-gaap_PaymentsToAcquireOtherInvestments_C1DBF6CD150C1A994BBFF68085197430" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ProceedsFromSaleOfProductiveAssets" xlink:label="loc_us-gaap_ProceedsFromSaleOfProductiveAssets_6B3786C29A20C1386FC8F6808519FEF6" xlink:type="locator" />
    <presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperationsAbstract_BD79CFA30A3B51E2B22BF6808519E4D2" xlink:to="loc_us-gaap_ProceedsFromSaleOfProductiveAssets_6B3786C29A20C1386FC8F6808519FEF6" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PaymentsToAcquireIntangibleAssets" xlink:label="loc_us-gaap_PaymentsToAcquireIntangibleAssets_749A8F2733497E9FC4B8F68085198E93" xlink:type="locator" />
    <presentationArc order="9" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperationsAbstract_BD79CFA30A3B51E2B22BF6808519E4D2" xlink:to="loc_us-gaap_PaymentsToAcquireIntangibleAssets_749A8F2733497E9FC4B8F68085198E93" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PaymentsToAcquireInProcessResearchAndDevelopment" xlink:label="loc_us-gaap_PaymentsToAcquireInProcessResearchAndDevelopment_ABC44B7B36BF0B6FD883F680851997E2" xlink:type="locator" />
    <presentationArc order="10" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperationsAbstract_BD79CFA30A3B51E2B22BF6808519E4D2" xlink:to="loc_us-gaap_PaymentsToAcquireInProcessResearchAndDevelopment_ABC44B7B36BF0B6FD883F680851997E2" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired" xlink:label="loc_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_2E79288733288AAFC1CFF6808519A18D" xlink:type="locator" />
    <presentationArc order="11" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperationsAbstract_BD79CFA30A3B51E2B22BF6808519E4D2" xlink:to="loc_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_2E79288733288AAFC1CFF6808519A18D" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PaymentsForProceedsFromOtherInvestingActivities" xlink:label="loc_us-gaap_PaymentsForProceedsFromOtherInvestingActivities_0086E5E6008C3F074923F6808519A805" xlink:type="locator" />
    <presentationArc order="12" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperationsAbstract_BD79CFA30A3B51E2B22BF6808519E4D2" xlink:to="loc_us-gaap_PaymentsForProceedsFromOtherInvestingActivities_0086E5E6008C3F074923F6808519A805" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_83A506B73A39EAEB4C11F6808519C4A3" xlink:type="locator" />
    <presentationArc order="13" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperationsAbstract_BD79CFA30A3B51E2B22BF6808519E4D2" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_83A506B73A39EAEB4C11F6808519C4A3" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_F16552C42B11F2B3A50EF680851933C7" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CashAndCashEquivalentsPeriodIncreaseDecreaseAbstract_95735B05F3FC0461A9ECF6808519275E" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_F16552C42B11F2B3A50EF680851933C7" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperationsAbstract" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperationsAbstract_3F3B298A2E75E571CB47F6808519E0C1" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_F16552C42B11F2B3A50EF680851933C7" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperationsAbstract_3F3B298A2E75E571CB47F6808519E0C1" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PaymentsOfDividends" xlink:label="loc_us-gaap_PaymentsOfDividends_3C1B37BDD9E6BF11F4B5F68085192E19" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperationsAbstract_3F3B298A2E75E571CB47F6808519E0C1" xlink:to="loc_us-gaap_PaymentsOfDividends_3C1B37BDD9E6BF11F4B5F68085192E19" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ProceedsFromRepaymentsOfShortTermDebt" xlink:label="loc_us-gaap_ProceedsFromRepaymentsOfShortTermDebt_4DA05689C7A521D1932BF6808519AD49" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperationsAbstract_3F3B298A2E75E571CB47F6808519E0C1" xlink:to="loc_us-gaap_ProceedsFromRepaymentsOfShortTermDebt_4DA05689C7A521D1932BF6808519AD49" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ProceedsFromIssuanceOfLongTermDebt" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfLongTermDebt_7819E74EC674C2660AE2F6808519B1B9" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperationsAbstract_3F3B298A2E75E571CB47F6808519E0C1" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfLongTermDebt_7819E74EC674C2660AE2F6808519B1B9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_RepaymentsOfLongTermDebt" xlink:label="loc_us-gaap_RepaymentsOfLongTermDebt_9A0831F1210A0D93D326F68085190617" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperationsAbstract_3F3B298A2E75E571CB47F6808519E0C1" xlink:to="loc_us-gaap_RepaymentsOfLongTermDebt_9A0831F1210A0D93D326F68085190617" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PaymentsForRepurchaseOfCommonStock" xlink:label="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_0654BB162C7CC7942F24F6808519C207" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperationsAbstract_3F3B298A2E75E571CB47F6808519E0C1" xlink:to="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_0654BB162C7CC7942F24F6808519C207" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ProceedsFromPaymentsForOtherFinancingActivities" xlink:label="loc_us-gaap_ProceedsFromPaymentsForOtherFinancingActivities_DF8498AF9388D4BD75BFF6808519D137" xlink:type="locator" />
    <presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperationsAbstract_3F3B298A2E75E571CB47F6808519E0C1" xlink:to="loc_us-gaap_ProceedsFromPaymentsForOtherFinancingActivities_DF8498AF9388D4BD75BFF6808519D137" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_AD9BF674119364335D3EF68085195111" xlink:type="locator" />
    <presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperationsAbstract_3F3B298A2E75E571CB47F6808519E0C1" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_AD9BF674119364335D3EF68085195111" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_EffectOfExchangeRateOnCashAndCashEquivalents" xlink:label="loc_us-gaap_EffectOfExchangeRateOnCashAndCashEquivalents_36DB08DE98D72D5C6844F6808519C6DB" xlink:type="locator" />
    <presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperationsAbstract_3F3B298A2E75E571CB47F6808519E0C1" xlink:to="loc_us-gaap_EffectOfExchangeRateOnCashAndCashEquivalents_36DB08DE98D72D5C6844F6808519C6DB" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CashAndCashEquivalentsPeriodIncreaseDecrease" xlink:label="loc_us-gaap_CashAndCashEquivalentsPeriodIncreaseDecrease_66443CEEAC4152C87246F68085194243" xlink:type="locator" />
    <presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperationsAbstract_3F3B298A2E75E571CB47F6808519E0C1" xlink:to="loc_us-gaap_CashAndCashEquivalentsPeriodIncreaseDecrease_66443CEEAC4152C87246F68085194243" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_1C26309A6AF1701B2ADEF6808519E9B8" xlink:type="locator" />
    <presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperationsAbstract_3F3B298A2E75E571CB47F6808519E0C1" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_1C26309A6AF1701B2ADEF6808519E9B8" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_3EE918E2F58D414A64F5F6808519B722" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_D6E537F785ECEAEC1212F680851979F5" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_3EE918E2F58D414A64F5F6808519B722" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.lilly.com/role/ConsolidatedStatementsOfComprehensiveIncomeLoss" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StatementOfIncomeAndComprehensiveIncomeAbstract" xlink:label="loc_us-gaap_StatementOfIncomeAndComprehensiveIncomeAbstract_490EBA972CE6D728C9AFF68085382C95" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StatementTable" xlink:label="loc_us-gaap_StatementTable_EDD3E66D8EF753024458F6808538A054" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfIncomeAndComprehensiveIncomeAbstract_490EBA972CE6D728C9AFF68085382C95" xlink:to="loc_us-gaap_StatementTable_EDD3E66D8EF753024458F6808538A054" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StatementScenarioAxis" xlink:label="loc_us-gaap_StatementScenarioAxis_B7F639278DF5C3EE4DE1F6808538C448" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_EDD3E66D8EF753024458F6808538A054" xlink:to="loc_us-gaap_StatementScenarioAxis_B7F639278DF5C3EE4DE1F6808538C448" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScenarioUnspecifiedDomain" xlink:label="loc_us-gaap_ScenarioUnspecifiedDomain_3B34B7D6434160CBB12AF6808538B671" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementScenarioAxis_B7F639278DF5C3EE4DE1F6808538C448" xlink:to="loc_us-gaap_ScenarioUnspecifiedDomain_3B34B7D6434160CBB12AF6808538B671" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_6718E7854E74CE196990F68085386476" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_EDD3E66D8EF753024458F6808538A054" xlink:to="loc_us-gaap_StatementLineItems_6718E7854E74CE196990F68085386476" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_NetIncomeLoss" xlink:label="loc_us-gaap_NetIncomeLoss_4776E700D6BD59426A62F6808538BB0F" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_6718E7854E74CE196990F68085386476" xlink:to="loc_us-gaap_NetIncomeLoss_4776E700D6BD59426A62F6808538BB0F" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossBeforeTaxPeriodIncreaseDecreaseAbstract" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossBeforeTaxPeriodIncreaseDecreaseAbstract_242D322244A17E711529F6808538F10F" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_6718E7854E74CE196990F68085386476" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossBeforeTaxPeriodIncreaseDecreaseAbstract_242D322244A17E711529F6808538F10F" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationGainLossBeforeReclassificationAndTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationGainLossBeforeReclassificationAndTax_C843F9AFDB8E1E32DA31F6808538D0B7" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossBeforeTaxPeriodIncreaseDecreaseAbstract_242D322244A17E711529F6808538F10F" xlink:to="loc_us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationGainLossBeforeReclassificationAndTax_C843F9AFDB8E1E32DA31F6808538D0B7" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentBeforeTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentBeforeTax_4544CEA862E253591958F6808538307B" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossBeforeTaxPeriodIncreaseDecreaseAbstract_242D322244A17E711529F6808538F10F" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentBeforeTax_4544CEA862E253591958F6808538307B" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansAdjustmentBeforeTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansAdjustmentBeforeTax_3B9871FE36A45A555D28F6808538A75D" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossBeforeTaxPeriodIncreaseDecreaseAbstract_242D322244A17E711529F6808538F10F" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansAdjustmentBeforeTax_3B9871FE36A45A555D28F6808538A75D" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossDerivativesQualifyingAsHedgesBeforeTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossDerivativesQualifyingAsHedgesBeforeTax_5D16A0846A58C5188C89F6808538093B" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossBeforeTaxPeriodIncreaseDecreaseAbstract_242D322244A17E711529F6808538F10F" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossDerivativesQualifyingAsHedgesBeforeTax_5D16A0846A58C5188C89F6808538093B" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossBeforeTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossBeforeTax_CAAC418AFE3A5CCCEA5BF6808538B44B" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossBeforeTaxPeriodIncreaseDecreaseAbstract_242D322244A17E711529F6808538F10F" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossBeforeTax_CAAC418AFE3A5CCCEA5BF6808538B44B" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossTax_6B34288A88B770718BABF680853845F2" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_6718E7854E74CE196990F68085386476" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossTax_6B34288A88B770718BABF680853845F2" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_630DBD5955567CAC2BCEF68085389452" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_6718E7854E74CE196990F68085386476" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_630DBD5955567CAC2BCEF68085389452" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ComprehensiveIncomeNetOfTax" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_6163E5FCB1CCEBEE6460F68085381380" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_6718E7854E74CE196990F68085386476" xlink:to="loc_us-gaap_ComprehensiveIncomeNetOfTax_6163E5FCB1CCEBEE6460F68085381380" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.lilly.com/role/ConsolidatedStatementsOfOperations" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_IncomeStatementAbstract" xlink:label="loc_us-gaap_IncomeStatementAbstract_B916321CF566DF0730DCFA3A07DE6F6E" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StatementTable" xlink:label="loc_us-gaap_StatementTable_BFF84453E814A623688DFA3A07DEE707" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_B916321CF566DF0730DCFA3A07DE6F6E" xlink:to="loc_us-gaap_StatementTable_BFF84453E814A623688DFA3A07DEE707" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StatementScenarioAxis" xlink:label="loc_us-gaap_StatementScenarioAxis_B8312B087FDA0F1238A1FA3A07DE6E4E" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_BFF84453E814A623688DFA3A07DEE707" xlink:to="loc_us-gaap_StatementScenarioAxis_B8312B087FDA0F1238A1FA3A07DE6E4E" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScenarioUnspecifiedDomain" xlink:label="loc_us-gaap_ScenarioUnspecifiedDomain_A0508A0A6F4EAF894D1CFA3A07DEDA83" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementScenarioAxis_B8312B087FDA0F1238A1FA3A07DE6E4E" xlink:to="loc_us-gaap_ScenarioUnspecifiedDomain_A0508A0A6F4EAF894D1CFA3A07DEDA83" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_90B86582FFB6787FF7EFFA3A07DE8DC3" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_BFF84453E814A623688DFA3A07DEE707" xlink:to="loc_us-gaap_StatementLineItems_90B86582FFB6787FF7EFFA3A07DE8DC3" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_Revenues" xlink:label="loc_us-gaap_Revenues_100CF071BFA44D189A3FFA3A07DE00DA" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_90B86582FFB6787FF7EFFA3A07DE8DC3" xlink:to="loc_us-gaap_Revenues_100CF071BFA44D189A3FFA3A07DE00DA" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CostOfGoodsSold" xlink:label="loc_us-gaap_CostOfGoodsSold_7BCAD4B78A44DFD41654FA3A07DEE9EE" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_90B86582FFB6787FF7EFFA3A07DE8DC3" xlink:to="loc_us-gaap_CostOfGoodsSold_7BCAD4B78A44DFD41654FA3A07DEE9EE" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ResearchAndDevelopmentExpense" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_89C2199228204CD5C0BAFA3A07DE8E0E" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_90B86582FFB6787FF7EFFA3A07DE8DC3" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_89C2199228204CD5C0BAFA3A07DE8E0E" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_SellingGeneralAndAdministrativeExpense" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpense_FCF063B325E2EAF89207FA3A07DEA6CE" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_90B86582FFB6787FF7EFFA3A07DE8DC3" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpense_FCF063B325E2EAF89207FA3A07DEA6CE" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_AcquiredInProcessResearchAndDevelopment" xlink:label="loc_lly_AcquiredInProcessResearchAndDevelopment_7549ABEB2CF1B8B41054FA3A07DEB7A2" xlink:type="locator" />
    <presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_90B86582FFB6787FF7EFFA3A07DE8DC3" xlink:to="loc_lly_AcquiredInProcessResearchAndDevelopment_7549ABEB2CF1B8B41054FA3A07DEB7A2" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_RestructuringSettlementAndImpairmentProvisions" xlink:label="loc_us-gaap_RestructuringSettlementAndImpairmentProvisions_4E6977370C07105BFC8AFA3A07DEFD48" xlink:type="locator" />
    <presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_90B86582FFB6787FF7EFFA3A07DE8DC3" xlink:to="loc_us-gaap_RestructuringSettlementAndImpairmentProvisions_4E6977370C07105BFC8AFA3A07DEFD48" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_NonoperatingIncomeExpense" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_6AAF59E078B1CF6DE4BFFA3A07DE8EA6" xlink:type="locator" />
    <presentationArc order="7" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_90B86582FFB6787FF7EFFA3A07DE8DC3" xlink:to="loc_us-gaap_NonoperatingIncomeExpense_6AAF59E078B1CF6DE4BFFA3A07DE8EA6" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_CostOfSalesOperatingExpensesAndOtherNet" xlink:label="loc_lly_CostOfSalesOperatingExpensesAndOtherNet_CAF6FE2EBEEDD85401F2FA3A07DEECF8" xlink:type="locator" />
    <presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_90B86582FFB6787FF7EFFA3A07DE8DC3" xlink:to="loc_lly_CostOfSalesOperatingExpensesAndOtherNet_CAF6FE2EBEEDD85401F2FA3A07DEECF8" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_E88E0BD3F23AB12B723BFA3A07DEFFF9" xlink:type="locator" />
    <presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_90B86582FFB6787FF7EFFA3A07DE8DC3" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_E88E0BD3F23AB12B723BFA3A07DEFFF9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_1090647F397F2FFFAE9FFA3A07DE218F" xlink:type="locator" />
    <presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_90B86582FFB6787FF7EFFA3A07DE8DC3" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_1090647F397F2FFFAE9FFA3A07DE218F" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_IncomeTaxExpenseBenefit" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_54B59CA069CA987E93B8FA3A07DEFAF4" xlink:type="locator" />
    <presentationArc order="11" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_90B86582FFB6787FF7EFFA3A07DE8DC3" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_54B59CA069CA987E93B8FA3A07DEFAF4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_NetIncomeLoss" xlink:label="loc_us-gaap_NetIncomeLoss_2ACB195D10A5D9E6B142FA3A07DEF2B5" xlink:type="locator" />
    <presentationArc order="12" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_90B86582FFB6787FF7EFFA3A07DE8DC3" xlink:to="loc_us-gaap_NetIncomeLoss_2ACB195D10A5D9E6B142FA3A07DEF2B5" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_EarningsPerShareAbstract" xlink:label="loc_us-gaap_EarningsPerShareAbstract_3DBB771E62EA767982DFFA3A07DE637D" xlink:type="locator" />
    <presentationArc order="13" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_90B86582FFB6787FF7EFFA3A07DE8DC3" xlink:to="loc_us-gaap_EarningsPerShareAbstract_3DBB771E62EA767982DFFA3A07DE637D" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_EarningsPerShareBasic" xlink:label="loc_us-gaap_EarningsPerShareBasic_B53EDC14228C8198729BFA3A07DE9E73" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareAbstract_3DBB771E62EA767982DFFA3A07DE637D" xlink:to="loc_us-gaap_EarningsPerShareBasic_B53EDC14228C8198729BFA3A07DE9E73" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_EarningsPerShareDiluted" xlink:label="loc_us-gaap_EarningsPerShareDiluted_FC9F9C819B0859093DCCFA3A07DE7DCB" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareAbstract_3DBB771E62EA767982DFFA3A07DE637D" xlink:to="loc_us-gaap_EarningsPerShareDiluted_FC9F9C819B0859093DCCFA3A07DE7DCB" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingAbstract" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingAbstract_090E3BC70645E9C23B0FFA3A07DE925B" xlink:type="locator" />
    <presentationArc order="14" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_90B86582FFB6787FF7EFFA3A07DE8DC3" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingAbstract_090E3BC70645E9C23B0FFA3A07DE925B" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingBasic" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_8CF70E79FC5D5865F0D9FA3A07DE9C32" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingAbstract_090E3BC70645E9C23B0FFA3A07DE925B" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_8CF70E79FC5D5865F0D9FA3A07DE9C32" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding" xlink:label="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_F0564B601E58A1B80173FA3A07DE04E2" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingAbstract_090E3BC70645E9C23B0FFA3A07DE925B" xlink:to="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_F0564B601E58A1B80173FA3A07DE04E2" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.lilly.com/role/ConsolidatedStatementsOfShareholdersEquityStatement" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StatementOfStockholdersEquityAbstract" xlink:label="loc_us-gaap_StatementOfStockholdersEquityAbstract_6547D486F5D5D49B8A16FA012EDEDBF3" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StatementTable" xlink:label="loc_us-gaap_StatementTable_7419D942FA3EFF011178FA012EDEAE73" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfStockholdersEquityAbstract_6547D486F5D5D49B8A16FA012EDEDBF3" xlink:to="loc_us-gaap_StatementTable_7419D942FA3EFF011178FA012EDEAE73" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StatementEquityComponentsAxis" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_88B486A999E6FB37D1E9FA012EDEC08F" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_7419D942FA3EFF011178FA012EDEAE73" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_88B486A999E6FB37D1E9FA012EDEC08F" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_EquityComponentDomain" xlink:label="loc_us-gaap_EquityComponentDomain_ED63C1CB9D8C22E88FFAFA012EDE2256" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_88B486A999E6FB37D1E9FA012EDEC08F" xlink:to="loc_us-gaap_EquityComponentDomain_ED63C1CB9D8C22E88FFAFA012EDE2256" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CommonStockMember" xlink:label="loc_us-gaap_CommonStockMember_9ACE5FC978C72B70B11AFA012EDE8E59" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_ED63C1CB9D8C22E88FFAFA012EDE2256" xlink:to="loc_us-gaap_CommonStockMember_9ACE5FC978C72B70B11AFA012EDE8E59" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AdditionalPaidInCapitalMember" xlink:label="loc_us-gaap_AdditionalPaidInCapitalMember_65E3126C7D22173DD813FA012EDEE652" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_ED63C1CB9D8C22E88FFAFA012EDE2256" xlink:to="loc_us-gaap_AdditionalPaidInCapitalMember_65E3126C7D22173DD813FA012EDEE652" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_RetainedEarningsMember" xlink:label="loc_us-gaap_RetainedEarningsMember_633795743993B3C3200BFA012EDEF976" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_ED63C1CB9D8C22E88FFAFA012EDE2256" xlink:to="loc_us-gaap_RetainedEarningsMember_633795743993B3C3200BFA012EDEF976" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeMember" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_BC2EB5D3797C2A5E1914FA012EDE4C77" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_ED63C1CB9D8C22E88FFAFA012EDE2256" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_BC2EB5D3797C2A5E1914FA012EDE4C77" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_TreasuryStockMember" xlink:label="loc_us-gaap_TreasuryStockMember_E140C617CAE18321C42CFA012EDE7B0F" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_ED63C1CB9D8C22E88FFAFA012EDE2256" xlink:to="loc_us-gaap_TreasuryStockMember_E140C617CAE18321C42CFA012EDE7B0F" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_TrustForBenefitOfEmployeesMember" xlink:label="loc_us-gaap_TrustForBenefitOfEmployeesMember_739DD8295330E3B5C1BAFA012EDEACE6" xlink:type="locator" />
    <presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_ED63C1CB9D8C22E88FFAFA012EDE2256" xlink:to="loc_us-gaap_TrustForBenefitOfEmployeesMember_739DD8295330E3B5C1BAFA012EDEACE6" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_C490CB90A500AF66394BFA012EDE179A" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_7419D942FA3EFF011178FA012EDEAE73" xlink:to="loc_us-gaap_StatementLineItems_C490CB90A500AF66394BFA012EDE179A" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_IncreaseDecreaseInStockholdersEquityRollForward" xlink:label="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_A537A5B8E6FA4C4CB095FA012EDE897C" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_C490CB90A500AF66394BFA012EDE179A" xlink:to="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_A537A5B8E6FA4C4CB095FA012EDE897C" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_SharesIssued" xlink:label="loc_us-gaap_SharesIssued_4CA1DA203B98E75909A2FA012EDEF971" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_A537A5B8E6FA4C4CB095FA012EDE897C" xlink:to="loc_us-gaap_SharesIssued_4CA1DA203B98E75909A2FA012EDEF971" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StockholdersEquity" xlink:label="loc_us-gaap_StockholdersEquity_517FD1165AC24D0118C0FA012EDE4CEA" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_A537A5B8E6FA4C4CB095FA012EDE897C" xlink:to="loc_us-gaap_StockholdersEquity_517FD1165AC24D0118C0FA012EDE4CEA" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_NetIncomeLoss" xlink:label="loc_us-gaap_NetIncomeLoss_8FABB432FCDC9D588598FA012EDE75A7" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_A537A5B8E6FA4C4CB095FA012EDE897C" xlink:to="loc_us-gaap_NetIncomeLoss_8FABB432FCDC9D588598FA012EDE75A7" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_FA97E044137812200D37FA012EDEA93D" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_A537A5B8E6FA4C4CB095FA012EDE897C" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_FA97E044137812200D37FA012EDEA93D" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_Dividends" xlink:label="loc_us-gaap_Dividends_580244E5DADABAAFE98EFA012EDE4ECF" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_A537A5B8E6FA4C4CB095FA012EDE897C" xlink:to="loc_us-gaap_Dividends_580244E5DADABAAFE98EFA012EDE4ECF" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_TreasuryStockSharesRetired" xlink:label="loc_us-gaap_TreasuryStockSharesRetired_832F0C53B86288420A15FA012EDE01C2" xlink:type="locator" />
    <presentationArc order="6" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_A537A5B8E6FA4C4CB095FA012EDE897C" xlink:to="loc_us-gaap_TreasuryStockSharesRetired_832F0C53B86288420A15FA012EDE01C2" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_TreasuryStockRetiredCostMethodAmount" xlink:label="loc_us-gaap_TreasuryStockRetiredCostMethodAmount_CA4B096B4A3072A1A508FA012EDE201C" xlink:type="locator" />
    <presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_A537A5B8E6FA4C4CB095FA012EDE897C" xlink:to="loc_us-gaap_TreasuryStockRetiredCostMethodAmount_CA4B096B4A3072A1A508FA012EDE201C" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_TreasuryStockSharesAcquired" xlink:label="loc_us-gaap_TreasuryStockSharesAcquired_1E1640FECE77DA29B5BDFA012EDE59C0" xlink:type="locator" />
    <presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_A537A5B8E6FA4C4CB095FA012EDE897C" xlink:to="loc_us-gaap_TreasuryStockSharesAcquired_1E1640FECE77DA29B5BDFA012EDE59C0" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_TreasuryStockValueAcquiredCostMethod" xlink:label="loc_us-gaap_TreasuryStockValueAcquiredCostMethod_5F96DD91C3E2088186FEFA012EDEEAEF" xlink:type="locator" />
    <presentationArc order="9" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_A537A5B8E6FA4C4CB095FA012EDE897C" xlink:to="loc_us-gaap_TreasuryStockValueAcquiredCostMethod_5F96DD91C3E2088186FEFA012EDEEAEF" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesEmployeeStockPurchasePlans" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesEmployeeStockPurchasePlans_69037D57610F499ECE6EFA012EDE0D1E" xlink:type="locator" />
    <presentationArc order="10" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_A537A5B8E6FA4C4CB095FA012EDE897C" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesEmployeeStockPurchasePlans_69037D57610F499ECE6EFA012EDE0D1E" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueEmployeeStockPurchasePlan" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueEmployeeStockPurchasePlan_505473A17DC3A1CAF583FA012EDE55BE" xlink:type="locator" />
    <presentationArc order="11" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_A537A5B8E6FA4C4CB095FA012EDE897C" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueEmployeeStockPurchasePlan_505473A17DC3A1CAF583FA012EDE55BE" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueShareBasedCompensation" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueShareBasedCompensation_47A1F506332EA8EDAAB4FA012EDE59FF" xlink:type="locator" />
    <presentationArc order="12" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_A537A5B8E6FA4C4CB095FA012EDE897C" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueShareBasedCompensation_47A1F506332EA8EDAAB4FA012EDE59FF" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StockholdersEquity" xlink:label="loc_us-gaap_StockholdersEquity_09BDE46EB355446EB13DFA012EDEFDE3" xlink:type="locator" />
    <presentationArc order="13" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_A537A5B8E6FA4C4CB095FA012EDE897C" xlink:to="loc_us-gaap_StockholdersEquity_09BDE46EB355446EB13DFA012EDEFDE3" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_SharesIssued" xlink:label="loc_us-gaap_SharesIssued_983F1EB0083B848AEE18FA012EDEE3EB" xlink:type="locator" />
    <presentationArc order="14" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_A537A5B8E6FA4C4CB095FA012EDE897C" xlink:to="loc_us-gaap_SharesIssued_983F1EB0083B848AEE18FA012EDEE3EB" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.lilly.com/role/Contingencies" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_LossContingencyInformationAboutLitigationMattersAbstract" xlink:label="loc_us-gaap_LossContingencyInformationAboutLitigationMattersAbstract_3BBF2E14A84ECF259DB1FC036EC5B035" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CommitmentsAndContingenciesDisclosureTextBlock" xlink:label="loc_us-gaap_CommitmentsAndContingenciesDisclosureTextBlock_144D57C954B4762761D5FC036EC5BCAF" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LossContingencyInformationAboutLitigationMattersAbstract_3BBF2E14A84ECF259DB1FC036EC5B035" xlink:to="loc_us-gaap_CommitmentsAndContingenciesDisclosureTextBlock_144D57C954B4762761D5FC036EC5BCAF" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.lilly.com/role/ContingenciesContingenciesPolicies" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CommitmentsAndContingenciesDisclosureAbstract" xlink:label="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_E52D051D657C42125BB7FC037023566C" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CommitmentsAndContingenciesPolicyTextBlock" xlink:label="loc_us-gaap_CommitmentsAndContingenciesPolicyTextBlock_5A8D253E1A62F43FF07AFC037023208D" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_E52D051D657C42125BB7FC037023566C" xlink:to="loc_us-gaap_CommitmentsAndContingenciesPolicyTextBlock_5A8D253E1A62F43FF07AFC037023208D" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.lilly.com/role/ContingenciesDetails" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_LossContingencyInformationAboutLitigationMattersAbstract" xlink:label="loc_us-gaap_LossContingencyInformationAboutLitigationMattersAbstract_8D74B780670042D216D8EA6D678FD9D2" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_LossContingenciesTable" xlink:label="loc_us-gaap_LossContingenciesTable_FAD2EEBA280C37DA222DEA6D678F515D" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LossContingencyInformationAboutLitigationMattersAbstract_8D74B780670042D216D8EA6D678FD9D2" xlink:to="loc_us-gaap_LossContingenciesTable_FAD2EEBA280C37DA222DEA6D678F515D" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StatementGeographicalAxis" xlink:label="loc_us-gaap_StatementGeographicalAxis_A7D00A942922B3F84528EA6D678F0AB7" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LossContingenciesTable_FAD2EEBA280C37DA222DEA6D678F515D" xlink:to="loc_us-gaap_StatementGeographicalAxis_A7D00A942922B3F84528EA6D678F0AB7" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_SegmentGeographicalDomain" xlink:label="loc_us-gaap_SegmentGeographicalDomain_D314165ADD336627CFDEEA6D678FB216" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementGeographicalAxis_A7D00A942922B3F84528EA6D678F0AB7" xlink:to="loc_us-gaap_SegmentGeographicalDomain_D314165ADD336627CFDEEA6D678FB216" xlink:type="arc" />
    <loc xlink:href="http://xbrl.sec.gov/country/2013/country-2013-01-31.xsd#country_CA" xlink:label="loc_country_CA_8C00A87EC317DC0608F2EA6D678F40F9" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentGeographicalDomain_D314165ADD336627CFDEEA6D678FB216" xlink:to="loc_country_CA_8C00A87EC317DC0608F2EA6D678F40F9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.sec.gov/stpr/2011/stpr-2011-01-31.xsd#stpr_CA" xlink:label="loc_stpr_CA_A32AF1F6C57D59141C78EA6D678F254D" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentGeographicalDomain_D314165ADD336627CFDEEA6D678FB216" xlink:to="loc_stpr_CA_A32AF1F6C57D59141C78EA6D678F254D" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_OtherstatesMember" xlink:label="loc_lly_OtherstatesMember_0CB940054FD9DB7E2C6CEA6D678F8B4F" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentGeographicalDomain_D314165ADD336627CFDEEA6D678FB216" xlink:to="loc_lly_OtherstatesMember_0CB940054FD9DB7E2C6CEA6D678F8B4F" xlink:type="arc" />
    <loc xlink:href="http://xbrl.sec.gov/country/2013/country-2013-01-31.xsd#country_BR" xlink:label="loc_country_BR_9D9A0DC0F7E2B491269CEA6D679010BE" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentGeographicalDomain_D314165ADD336627CFDEEA6D678FB216" xlink:to="loc_country_BR_9D9A0DC0F7E2B491269CEA6D679010BE" xlink:type="arc" />
    <loc xlink:href="http://xbrl.sec.gov/stpr/2011/stpr-2011-01-31.xsd#stpr_A6" xlink:label="loc_stpr_A6_785DD8C169CD1878FD43EA6D6790E18B" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentGeographicalDomain_D314165ADD336627CFDEEA6D678FB216" xlink:to="loc_stpr_A6_785DD8C169CD1878FD43EA6D6790E18B" xlink:type="arc" />
    <loc xlink:href="http://xbrl.sec.gov/stpr/2011/stpr-2011-01-31.xsd#stpr_A8" xlink:label="loc_stpr_A8_48EB2435A55A09D5857AEA6D6790FFC3" xlink:type="locator" />
    <presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentGeographicalDomain_D314165ADD336627CFDEEA6D678FB216" xlink:to="loc_stpr_A8_48EB2435A55A09D5857AEA6D6790FFC3" xlink:type="arc" />
    <loc xlink:href="http://xbrl.sec.gov/stpr/2011/stpr-2011-01-31.xsd#stpr_A0" xlink:label="loc_stpr_A0_565AF147B157FE0DF721EA6D6790102C" xlink:type="locator" />
    <presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentGeographicalDomain_D314165ADD336627CFDEEA6D678FB216" xlink:to="loc_stpr_A0_565AF147B157FE0DF721EA6D6790102C" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_LossContingenciesByNatureOfContingencyAxis" xlink:label="loc_us-gaap_LossContingenciesByNatureOfContingencyAxis_0FAC6C5DE0B050F1B912EA6D67909134" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LossContingenciesTable_FAD2EEBA280C37DA222DEA6D678F515D" xlink:to="loc_us-gaap_LossContingenciesByNatureOfContingencyAxis_0FAC6C5DE0B050F1B912EA6D67909134" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_LossContingencyNatureDomain" xlink:label="loc_us-gaap_LossContingencyNatureDomain_35607F0DFF86399564D8EA6D6790228F" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LossContingenciesByNatureOfContingencyAxis_0FAC6C5DE0B050F1B912EA6D67909134" xlink:to="loc_us-gaap_LossContingencyNatureDomain_35607F0DFF86399564D8EA6D6790228F" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_CompensatoryDamagesMember" xlink:label="loc_lly_CompensatoryDamagesMember_189B2B06B3760CF72B12EA6D67902EE0" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LossContingencyNatureDomain_35607F0DFF86399564D8EA6D6790228F" xlink:to="loc_lly_CompensatoryDamagesMember_189B2B06B3760CF72B12EA6D67902EE0" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_PunitiveDamagesMember" xlink:label="loc_lly_PunitiveDamagesMember_F96C5D55DB521D46D42DEA6D67904DED" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LossContingencyNatureDomain_35607F0DFF86399564D8EA6D6790228F" xlink:to="loc_lly_PunitiveDamagesMember_F96C5D55DB521D46D42DEA6D67904DED" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_ProductLiabilityLitigationMember" xlink:label="loc_lly_ProductLiabilityLitigationMember_11B932260E993728B8CBEA6D6790DED2" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LossContingencyNatureDomain_35607F0DFF86399564D8EA6D6790228F" xlink:to="loc_lly_ProductLiabilityLitigationMember_11B932260E993728B8CBEA6D6790DED2" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_DamagesfromProductCancerMember" xlink:label="loc_lly_DamagesfromProductCancerMember_EC823E8B8AF91DE60B0FEA6D67905CF0" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LossContingencyNatureDomain_35607F0DFF86399564D8EA6D6790228F" xlink:to="loc_lly_DamagesfromProductCancerMember_EC823E8B8AF91DE60B0FEA6D67905CF0" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ProductOrServiceAxis" xlink:label="loc_us-gaap_ProductOrServiceAxis_1A4087C909CD121E25DFEA6D67906177" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LossContingenciesTable_FAD2EEBA280C37DA222DEA6D678F515D" xlink:to="loc_us-gaap_ProductOrServiceAxis_1A4087C909CD121E25DFEA6D67906177" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ProductsAndServicesDomain" xlink:label="loc_us-gaap_ProductsAndServicesDomain_94D259D1C5581BAC6A62EA6D67901DE7" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ProductOrServiceAxis_1A4087C909CD121E25DFEA6D67906177" xlink:to="loc_us-gaap_ProductsAndServicesDomain_94D259D1C5581BAC6A62EA6D67901DE7" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_ActosMember" xlink:label="loc_lly_ActosMember_9037AC11C6FF1BA3E588EA6D6790D5ED" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ProductsAndServicesDomain_94D259D1C5581BAC6A62EA6D67901DE7" xlink:to="loc_lly_ActosMember_9037AC11C6FF1BA3E588EA6D6790D5ED" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_ByettaMember" xlink:label="loc_lly_ByettaMember_062A7379D78924F69AC8EA6D6790FAEB" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ProductsAndServicesDomain_94D259D1C5581BAC6A62EA6D67901DE7" xlink:to="loc_lly_ByettaMember_062A7379D78924F69AC8EA6D6790FAEB" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_CymbaltaMember" xlink:label="loc_lly_CymbaltaMember_D44B9976806C036769CCEA6D67900656" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ProductsAndServicesDomain_94D259D1C5581BAC6A62EA6D67901DE7" xlink:to="loc_lly_CymbaltaMember_D44B9976806C036769CCEA6D67900656" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_ProzacMember" xlink:label="loc_lly_ProzacMember_657FE005DD5C752A2091EA6D67908CD0" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ProductsAndServicesDomain_94D259D1C5581BAC6A62EA6D67901DE7" xlink:to="loc_lly_ProzacMember_657FE005DD5C752A2091EA6D67908CD0" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_LitigationCaseAxis" xlink:label="loc_us-gaap_LitigationCaseAxis_75C675679A893EFF5BCDEA6D67906EE4" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LossContingenciesTable_FAD2EEBA280C37DA222DEA6D678F515D" xlink:to="loc_us-gaap_LitigationCaseAxis_75C675679A893EFF5BCDEA6D67906EE4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_LitigationCaseTypeDomain" xlink:label="loc_us-gaap_LitigationCaseTypeDomain_0F86B03344C9D467EB2DEA6D6791744F" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LitigationCaseAxis_75C675679A893EFF5BCDEA6D67906EE4" xlink:to="loc_us-gaap_LitigationCaseTypeDomain_0F86B03344C9D467EB2DEA6D6791744F" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_MultiDistrictLitigationMdlMember" xlink:label="loc_lly_MultiDistrictLitigationMdlMember_9733526D47E29B78FDF1EA6D6791CDAF" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LitigationCaseTypeDomain_0F86B03344C9D467EB2DEA6D6791744F" xlink:to="loc_lly_MultiDistrictLitigationMdlMember_9733526D47E29B78FDF1EA6D6791CDAF" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_TakedaPortionMember" xlink:label="loc_lly_TakedaPortionMember_B1E209AF729B2ABC5B4AEA6D67913AB6" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LitigationCaseTypeDomain_0F86B03344C9D467EB2DEA6D6791744F" xlink:to="loc_lly_TakedaPortionMember_B1E209AF729B2ABC5B4AEA6D67913AB6" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_LillyPortionMember" xlink:label="loc_lly_LillyPortionMember_67FA883DB5D219E790EFEA6D67913BE4" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LitigationCaseTypeDomain_0F86B03344C9D467EB2DEA6D6791744F" xlink:to="loc_lly_LillyPortionMember_67FA883DB5D219E790EFEA6D67913BE4" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_EmployeeLitigationMember" xlink:label="loc_lly_EmployeeLitigationMember_597392D24FA82C20481CEA6D6791B8A3" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LitigationCaseTypeDomain_0F86B03344C9D467EB2DEA6D6791744F" xlink:to="loc_lly_EmployeeLitigationMember_597392D24FA82C20481CEA6D6791B8A3" xlink:type="arc" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LitigationCaseTypeDomain_0F86B03344C9D467EB2DEA6D6791744F" xlink:to="loc_lly_ProductLiabilityLitigationMember_11B932260E993728B8CBEA6D6790DED2" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_EBABF8E50296D04621E2EA6D6791960A" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LossContingenciesTable_FAD2EEBA280C37DA222DEA6D678F515D" xlink:to="loc_us-gaap_StatementLineItems_EBABF8E50296D04621E2EA6D6791960A" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_LossContingencyNumberOfCases" xlink:label="loc_lly_LossContingencyNumberOfCases_89AFCCD394BD108800C0EA6D67917560" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_EBABF8E50296D04621E2EA6D6791960A" xlink:to="loc_lly_LossContingencyNumberOfCases_89AFCCD394BD108800C0EA6D67917560" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_LossContingencyDamagesAwardedValue" xlink:label="loc_us-gaap_LossContingencyDamagesAwardedValue_B72D9A39FD59FC0AC6C1EA6D6791F625" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_EBABF8E50296D04621E2EA6D6791960A" xlink:to="loc_us-gaap_LossContingencyDamagesAwardedValue_B72D9A39FD59FC0AC6C1EA6D6791F625" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_LossContingencyPartiesJointlyandSeverallyLiableinLitigationPercentShare" xlink:label="loc_lly_LossContingencyPartiesJointlyandSeverallyLiableinLitigationPercentShare_0CE7D31DB6F281B027E9EA6D67918BEC" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_EBABF8E50296D04621E2EA6D6791960A" xlink:to="loc_lly_LossContingencyPartiesJointlyandSeverallyLiableinLitigationPercentShare_0CE7D31DB6F281B027E9EA6D67918BEC" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_LossContingencyNumberOfClaimants" xlink:label="loc_lly_LossContingencyNumberOfClaimants_A28BDF002BE56B6F2E9EEA6D6791B745" xlink:type="locator" />
    <presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_EBABF8E50296D04621E2EA6D6791960A" xlink:to="loc_lly_LossContingencyNumberOfClaimants_A28BDF002BE56B6F2E9EEA6D6791B745" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_LossContingencyNumberOfLawsuits" xlink:label="loc_lly_LossContingencyNumberOfLawsuits_5047C3B52C34046D45D0EA6D6791BF26" xlink:type="locator" />
    <presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_EBABF8E50296D04621E2EA6D6791960A" xlink:to="loc_lly_LossContingencyNumberOfLawsuits_5047C3B52C34046D45D0EA6D6791BF26" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_LossContingencyNumberOfPlaintiffs" xlink:label="loc_us-gaap_LossContingencyNumberOfPlaintiffs_EEAD933389C8C961E0D4EA6D679255A4" xlink:type="locator" />
    <presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_EBABF8E50296D04621E2EA6D6791960A" xlink:to="loc_us-gaap_LossContingencyNumberOfPlaintiffs_EEAD933389C8C961E0D4EA6D679255A4" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.lilly.com/role/DocumentAndEntityInformation" xlink:type="extended">
    <loc xlink:href="lly-20151231.xsd#lly_DocumentEntityInformationAbstract" xlink:label="loc_lly_DocumentEntityInformationAbstract_BEEEB47805F14552CB1AF5374B28BE8E" xlink:type="locator" />
    <loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_DocumentInformationTable" xlink:label="loc_dei_DocumentInformationTable_6DED3D24F6EAAAF188D4F5374B284352" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lly_DocumentEntityInformationAbstract_BEEEB47805F14552CB1AF5374B28BE8E" xlink:to="loc_dei_DocumentInformationTable_6DED3D24F6EAAAF188D4F5374B284352" xlink:type="arc" />
    <loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_DocumentInformationDocumentAxis" xlink:label="loc_dei_DocumentInformationDocumentAxis_5917868F9937F289B9A2F5374B280BE4" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationTable_6DED3D24F6EAAAF188D4F5374B284352" xlink:to="loc_dei_DocumentInformationDocumentAxis_5917868F9937F289B9A2F5374B280BE4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_DocumentDomain" xlink:label="loc_dei_DocumentDomain_ADAF78214F7B47C05904F5374B280149" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationDocumentAxis_5917868F9937F289B9A2F5374B280BE4" xlink:to="loc_dei_DocumentDomain_ADAF78214F7B47C05904F5374B280149" xlink:type="arc" />
    <loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_DocumentInformationLineItems" xlink:label="loc_dei_DocumentInformationLineItems_9FB1DC628357A98C3939F5374B29C106" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationTable_6DED3D24F6EAAAF188D4F5374B284352" xlink:to="loc_dei_DocumentInformationLineItems_9FB1DC628357A98C3939F5374B29C106" xlink:type="arc" />
    <loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_DocumentType" xlink:label="loc_dei_DocumentType_1F026745A6FB2BB2C11BF5374B29EF8E" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_9FB1DC628357A98C3939F5374B29C106" xlink:to="loc_dei_DocumentType_1F026745A6FB2BB2C11BF5374B29EF8E" xlink:type="arc" />
    <loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_AmendmentFlag" xlink:label="loc_dei_AmendmentFlag_F1D1EFF9BDF85B0E53DEF5374B29545A" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_9FB1DC628357A98C3939F5374B29C106" xlink:to="loc_dei_AmendmentFlag_F1D1EFF9BDF85B0E53DEF5374B29545A" xlink:type="arc" />
    <loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_DocumentPeriodEndDate" xlink:label="loc_dei_DocumentPeriodEndDate_D4D78E707EB77131EE55F5374B2983BF" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_9FB1DC628357A98C3939F5374B29C106" xlink:to="loc_dei_DocumentPeriodEndDate_D4D78E707EB77131EE55F5374B2983BF" xlink:type="arc" />
    <loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_DocumentFiscalYearFocus" xlink:label="loc_dei_DocumentFiscalYearFocus_41C06E4E7F14CA042D2FF5374B2999E9" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_9FB1DC628357A98C3939F5374B29C106" xlink:to="loc_dei_DocumentFiscalYearFocus_41C06E4E7F14CA042D2FF5374B2999E9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_DocumentFiscalPeriodFocus" xlink:label="loc_dei_DocumentFiscalPeriodFocus_4243512FF9CF03CA0116F5374B296E64" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_9FB1DC628357A98C3939F5374B29C106" xlink:to="loc_dei_DocumentFiscalPeriodFocus_4243512FF9CF03CA0116F5374B296E64" xlink:type="arc" />
    <loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_EntityRegistrantName" xlink:label="loc_dei_EntityRegistrantName_ACEC99458D97B564AB19F5374B290D35" xlink:type="locator" />
    <presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_9FB1DC628357A98C3939F5374B29C106" xlink:to="loc_dei_EntityRegistrantName_ACEC99458D97B564AB19F5374B290D35" xlink:type="arc" />
    <loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_EntityCentralIndexKey" xlink:label="loc_dei_EntityCentralIndexKey_E78DAC1BCAF565F55717F5374B29F0CE" xlink:type="locator" />
    <presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_9FB1DC628357A98C3939F5374B29C106" xlink:to="loc_dei_EntityCentralIndexKey_E78DAC1BCAF565F55717F5374B29F0CE" xlink:type="arc" />
    <loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_CurrentFiscalYearEndDate" xlink:label="loc_dei_CurrentFiscalYearEndDate_8C5016DA320321FA43BFF5374B290897" xlink:type="locator" />
    <presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_9FB1DC628357A98C3939F5374B29C106" xlink:to="loc_dei_CurrentFiscalYearEndDate_8C5016DA320321FA43BFF5374B290897" xlink:type="arc" />
    <loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_EntityWellKnownSeasonedIssuer" xlink:label="loc_dei_EntityWellKnownSeasonedIssuer_2366A91E31722EBCC746F5374B2945E0" xlink:type="locator" />
    <presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_9FB1DC628357A98C3939F5374B29C106" xlink:to="loc_dei_EntityWellKnownSeasonedIssuer_2366A91E31722EBCC746F5374B2945E0" xlink:type="arc" />
    <loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_EntityVoluntaryFilers" xlink:label="loc_dei_EntityVoluntaryFilers_7A92ABB6CDB8290FC6EEF5374B29191C" xlink:type="locator" />
    <presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_9FB1DC628357A98C3939F5374B29C106" xlink:to="loc_dei_EntityVoluntaryFilers_7A92ABB6CDB8290FC6EEF5374B29191C" xlink:type="arc" />
    <loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_EntityCurrentReportingStatus" xlink:label="loc_dei_EntityCurrentReportingStatus_0A320EFD38E264F5A8E9F5374B291C2E" xlink:type="locator" />
    <presentationArc order="11" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_9FB1DC628357A98C3939F5374B29C106" xlink:to="loc_dei_EntityCurrentReportingStatus_0A320EFD38E264F5A8E9F5374B291C2E" xlink:type="arc" />
    <loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_EntityFilerCategory" xlink:label="loc_dei_EntityFilerCategory_66F7C845CBF9AA60476CF5374B2973D6" xlink:type="locator" />
    <presentationArc order="12" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_9FB1DC628357A98C3939F5374B29C106" xlink:to="loc_dei_EntityFilerCategory_66F7C845CBF9AA60476CF5374B2973D6" xlink:type="arc" />
    <loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_EntityPublicFloat" xlink:label="loc_dei_EntityPublicFloat_AD145C8408C12F48A1B4F5374B2987A7" xlink:type="locator" />
    <presentationArc order="13" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_9FB1DC628357A98C3939F5374B29C106" xlink:to="loc_dei_EntityPublicFloat_AD145C8408C12F48A1B4F5374B2987A7" xlink:type="arc" />
    <loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_EntityCommonStockSharesOutstanding" xlink:label="loc_dei_EntityCommonStockSharesOutstanding_5382CE1E230A67E467C9F5374B297E51" xlink:type="locator" />
    <presentationArc order="14" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_9FB1DC628357A98C3939F5374B29C106" xlink:to="loc_dei_EntityCommonStockSharesOutstanding_5382CE1E230A67E467C9F5374B297E51" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.lilly.com/role/EarningsLossPerShareDetails" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_EarningsPerShareAbstract" xlink:label="loc_us-gaap_EarningsPerShareAbstract_8D83A78DE64E892D094DF51571FC23EA" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StatementTable" xlink:label="loc_us-gaap_StatementTable_ADE7B2E6837A955D4D96F51571FCFD51" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareAbstract_8D83A78DE64E892D094DF51571FC23EA" xlink:to="loc_us-gaap_StatementTable_ADE7B2E6837A955D4D96F51571FCFD51" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_EarningsPerShareAxis" xlink:label="loc_lly_EarningsPerShareAxis_B1A2D8C79F6993248DB1F51571FCD633" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_ADE7B2E6837A955D4D96F51571FCFD51" xlink:to="loc_lly_EarningsPerShareAxis_B1A2D8C79F6993248DB1F51571FCD633" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_EarningsPerShareDomain" xlink:label="loc_lly_EarningsPerShareDomain_8D90D576882A7C5E0D78F51571FC79A0" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lly_EarningsPerShareAxis_B1A2D8C79F6993248DB1F51571FCD633" xlink:to="loc_lly_EarningsPerShareDomain_8D90D576882A7C5E0D78F51571FC79A0" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_8CD042F5A50FDC629DA1F51571FCCBBA" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_ADE7B2E6837A955D4D96F51571FCFD51" xlink:to="loc_us-gaap_StatementLineItems_8CD042F5A50FDC629DA1F51571FCCBBA" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_NetIncomeLoss" xlink:label="loc_us-gaap_NetIncomeLoss_6873D5C7730509366B86F51571FC188A" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_8CD042F5A50FDC629DA1F51571FCCBBA" xlink:to="loc_us-gaap_NetIncomeLoss_6873D5C7730509366B86F51571FC188A" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingBasic" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_6CF6459334FE4316509CF51571FC5F24" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_8CD042F5A50FDC629DA1F51571FCCBBA" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_6CF6459334FE4316509CF51571FC5F24" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_EarningsPerShareBasic" xlink:label="loc_us-gaap_EarningsPerShareBasic_A862D5406C16904E5E00F51571FC34E6" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_8CD042F5A50FDC629DA1F51571FCCBBA" xlink:to="loc_us-gaap_EarningsPerShareBasic_A862D5406C16904E5E00F51571FC34E6" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding" xlink:label="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_48E20C23C4B0A62E7C8FF51571FC9996" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_8CD042F5A50FDC629DA1F51571FCCBBA" xlink:to="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_48E20C23C4B0A62E7C8FF51571FC9996" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_EarningsPerShareDiluted" xlink:label="loc_us-gaap_EarningsPerShareDiluted_5DFDF355F1DF4F9C5443F51571FCB081" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_8CD042F5A50FDC629DA1F51571FCCBBA" xlink:to="loc_us-gaap_EarningsPerShareDiluted_5DFDF355F1DF4F9C5443F51571FCB081" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.lilly.com/role/FinancialInstruments" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract" xlink:label="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_EBED8C9CD470B962A8E2F6A235655B07" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FairValueDisclosuresTextBlock" xlink:label="loc_us-gaap_FairValueDisclosuresTextBlock_D10E8E3EFCE0EC734012F5374AA36FBB" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_EBED8C9CD470B962A8E2F6A235655B07" xlink:to="loc_us-gaap_FairValueDisclosuresTextBlock_D10E8E3EFCE0EC734012F5374AA36FBB" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.lilly.com/role/FinancialInstrumentsDetails" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract" xlink:label="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_85AE8E93C83D8EB252DBFB279704F266" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FairValueByBalanceSheetGroupingTable" xlink:label="loc_us-gaap_FairValueByBalanceSheetGroupingTable_B3C873865F77FE4103C8FB279704D390" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_85AE8E93C83D8EB252DBFB279704F266" xlink:to="loc_us-gaap_FairValueByBalanceSheetGroupingTable_B3C873865F77FE4103C8FB279704D390" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DebtInstrumentRedemptionPeriodAxis" xlink:label="loc_us-gaap_DebtInstrumentRedemptionPeriodAxis_E5BB537BF5D038020A75FB2797046E74" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByBalanceSheetGroupingTable_B3C873865F77FE4103C8FB279704D390" xlink:to="loc_us-gaap_DebtInstrumentRedemptionPeriodAxis_E5BB537BF5D038020A75FB2797046E74" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DebtInstrumentRedemptionPeriodDomain" xlink:label="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_8A2E79BEB1D70EF9BEE2FB279704B4FB" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentRedemptionPeriodAxis_E5BB537BF5D038020A75FB2797046E74" xlink:to="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_8A2E79BEB1D70EF9BEE2FB279704B4FB" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_EuroDenominatedDebtIssuanceMember" xlink:label="loc_lly_EuroDenominatedDebtIssuanceMember_D8FE7F02F9B09ACA3CEBFB279704D846" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_8A2E79BEB1D70EF9BEE2FB279704B4FB" xlink:to="loc_lly_EuroDenominatedDebtIssuanceMember_D8FE7F02F9B09ACA3CEBFB279704D846" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StatementGeographicalAxis" xlink:label="loc_us-gaap_StatementGeographicalAxis_3DB5C56D6FC910DA41ACFB279704FE88" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByBalanceSheetGroupingTable_B3C873865F77FE4103C8FB279704D390" xlink:to="loc_us-gaap_StatementGeographicalAxis_3DB5C56D6FC910DA41ACFB279704FE88" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_SegmentGeographicalDomain" xlink:label="loc_us-gaap_SegmentGeographicalDomain_BB099FE2AA696D4565FCFB27970459C5" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementGeographicalAxis_3DB5C56D6FC910DA41ACFB279704FE88" xlink:to="loc_us-gaap_SegmentGeographicalDomain_BB099FE2AA696D4565FCFB27970459C5" xlink:type="arc" />
    <loc xlink:href="http://xbrl.sec.gov/country/2013/country-2013-01-31.xsd#country_BR" xlink:label="loc_country_BR_80AA021D1B6E79DA699EFB279704B5BB" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentGeographicalDomain_BB099FE2AA696D4565FCFB27970459C5" xlink:to="loc_country_BR_80AA021D1B6E79DA699EFB279704B5BB" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_HedgingDesignationAxis" xlink:label="loc_us-gaap_HedgingDesignationAxis_2588CA9D8892259A19F2FB279704151D" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByBalanceSheetGroupingTable_B3C873865F77FE4103C8FB279704D390" xlink:to="loc_us-gaap_HedgingDesignationAxis_2588CA9D8892259A19F2FB279704151D" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_HedgingDesignationDomain" xlink:label="loc_us-gaap_HedgingDesignationDomain_2A02064A177D735CD08AFB2797045DAE" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_HedgingDesignationAxis_2588CA9D8892259A19F2FB279704151D" xlink:to="loc_us-gaap_HedgingDesignationDomain_2A02064A177D735CD08AFB2797045DAE" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DesignatedAsHedgingInstrumentMember" xlink:label="loc_us-gaap_DesignatedAsHedgingInstrumentMember_2DF878E6960E23671AC2FB279704FC0E" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_HedgingDesignationDomain_2A02064A177D735CD08AFB2797045DAE" xlink:to="loc_us-gaap_DesignatedAsHedgingInstrumentMember_2DF878E6960E23671AC2FB279704FC0E" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_NondesignatedMember" xlink:label="loc_us-gaap_NondesignatedMember_25586AB857E863656518FB27970411EC" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_HedgingDesignationDomain_2A02064A177D735CD08AFB2797045DAE" xlink:to="loc_us-gaap_NondesignatedMember_25586AB857E863656518FB27970411EC" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DerivativeByNatureAxis" xlink:label="loc_us-gaap_DerivativeByNatureAxis_5DE427880B59DC840836FB279704F005" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByBalanceSheetGroupingTable_B3C873865F77FE4103C8FB279704D390" xlink:to="loc_us-gaap_DerivativeByNatureAxis_5DE427880B59DC840836FB279704F005" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DerivativeNameDomain" xlink:label="loc_us-gaap_DerivativeNameDomain_48F70514179291BAE5A9FB2797041CCD" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeByNatureAxis_5DE427880B59DC840836FB279704F005" xlink:to="loc_us-gaap_DerivativeNameDomain_48F70514179291BAE5A9FB2797041CCD" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_BuyEuroSellUsDollarMember" xlink:label="loc_lly_BuyEuroSellUsDollarMember_7F5C4101F5AF0568FA6BFB279704E298" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeNameDomain_48F70514179291BAE5A9FB2797041CCD" xlink:to="loc_lly_BuyEuroSellUsDollarMember_7F5C4101F5AF0568FA6BFB279704E298" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_BuyUsdSellEuroMember" xlink:label="loc_lly_BuyUsdSellEuroMember_1D5E618735439C869264FB279704A3D8" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeNameDomain_48F70514179291BAE5A9FB2797041CCD" xlink:to="loc_lly_BuyUsdSellEuroMember_1D5E618735439C869264FB279704A3D8" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_BuyGBPSellEuroMember" xlink:label="loc_lly_BuyGBPSellEuroMember_D32374A49A4C6DCFCFB1FB2797048C1E" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeNameDomain_48F70514179291BAE5A9FB2797041CCD" xlink:to="loc_lly_BuyGBPSellEuroMember_D32374A49A4C6DCFCFB1FB2797048C1E" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_BuyUSdollarSellBritishpoundMember" xlink:label="loc_lly_BuyUSdollarSellBritishpoundMember_791D9AD442EFBF3E5A45FB2797049B15" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeNameDomain_48F70514179291BAE5A9FB2797041CCD" xlink:to="loc_lly_BuyUSdollarSellBritishpoundMember_791D9AD442EFBF3E5A45FB2797049B15" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_BuyUSdollarSellJapaneseYenMember" xlink:label="loc_lly_BuyUSdollarSellJapaneseYenMember_6DECDF5A04F3D98AF252FB279704FAD1" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeNameDomain_48F70514179291BAE5A9FB2797041CCD" xlink:to="loc_lly_BuyUSdollarSellJapaneseYenMember_6DECDF5A04F3D98AF252FB279704FAD1" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_MajorTypesOfDebtAndEquitySecuritiesAxis" xlink:label="loc_us-gaap_MajorTypesOfDebtAndEquitySecuritiesAxis_DED0281712BFE76EE5A4FB2797044CAE" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByBalanceSheetGroupingTable_B3C873865F77FE4103C8FB279704D390" xlink:to="loc_us-gaap_MajorTypesOfDebtAndEquitySecuritiesAxis_DED0281712BFE76EE5A4FB2797044CAE" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain" xlink:label="loc_us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain_421C17B63B20F803EB54FB279704DE49" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MajorTypesOfDebtAndEquitySecuritiesAxis_DED0281712BFE76EE5A4FB2797044CAE" xlink:to="loc_us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain_421C17B63B20F803EB54FB279704DE49" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CorporateDebtSecuritiesMember" xlink:label="loc_us-gaap_CorporateDebtSecuritiesMember_C3A959F0FEFF3B9B55E1FB279704D955" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain_421C17B63B20F803EB54FB279704DE49" xlink:to="loc_us-gaap_CorporateDebtSecuritiesMember_C3A959F0FEFF3B9B55E1FB279704D955" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_USGovernmentAgenciesDebtSecuritiesMember" xlink:label="loc_us-gaap_USGovernmentAgenciesDebtSecuritiesMember_0B38F63D7DA09D9B4A57FB279704CBBC" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain_421C17B63B20F803EB54FB279704DE49" xlink:to="loc_us-gaap_USGovernmentAgenciesDebtSecuritiesMember_0B38F63D7DA09D9B4A57FB279704CBBC" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OtherDebtSecuritiesMember" xlink:label="loc_us-gaap_OtherDebtSecuritiesMember_7D5A302AFDD088600D48FB279704643C" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain_421C17B63B20F803EB54FB279704DE49" xlink:to="loc_us-gaap_OtherDebtSecuritiesMember_7D5A302AFDD088600D48FB279704643C" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_MortgageBackedSecuritiesMember" xlink:label="loc_us-gaap_MortgageBackedSecuritiesMember_8AE5B10F2BD8982D6497FB279704F350" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain_421C17B63B20F803EB54FB279704DE49" xlink:to="loc_us-gaap_MortgageBackedSecuritiesMember_8AE5B10F2BD8982D6497FB279704F350" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AssetBackedSecuritiesMember" xlink:label="loc_us-gaap_AssetBackedSecuritiesMember_F8331EC0B64CF01FF9BBFB279704F128" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain_421C17B63B20F803EB54FB279704DE49" xlink:to="loc_us-gaap_AssetBackedSecuritiesMember_F8331EC0B64CF01FF9BBFB279704F128" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_EquitySecuritiesMember" xlink:label="loc_us-gaap_EquitySecuritiesMember_A631880B2A5444FF3134FB279704450C" xlink:type="locator" />
    <presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain_421C17B63B20F803EB54FB279704DE49" xlink:to="loc_us-gaap_EquitySecuritiesMember_A631880B2A5444FF3134FB279704450C" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_EquityMethodAndOtherInvestmentsMember" xlink:label="loc_lly_EquityMethodAndOtherInvestmentsMember_6F6656B454DC8D353BCAFB279704EADC" xlink:type="locator" />
    <presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain_421C17B63B20F803EB54FB279704DE49" xlink:to="loc_lly_EquityMethodAndOtherInvestmentsMember_6F6656B454DC8D353BCAFB279704EADC" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_E835ACFAC0A9A7F81221FB27970482A0" xlink:type="locator" />
    <presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByBalanceSheetGroupingTable_B3C873865F77FE4103C8FB279704D390" xlink:to="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_E835ACFAC0A9A7F81221FB27970482A0" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_DC5294B0E49E21B360E4FB279704741D" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_E835ACFAC0A9A7F81221FB27970482A0" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_DC5294B0E49E21B360E4FB279704741D" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FairValueInputsLevel1Member" xlink:label="loc_us-gaap_FairValueInputsLevel1Member_5057B85EF793D9A9C8F8FB279704B429" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_DC5294B0E49E21B360E4FB279704741D" xlink:to="loc_us-gaap_FairValueInputsLevel1Member_5057B85EF793D9A9C8F8FB279704B429" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FairValueInputsLevel2Member" xlink:label="loc_us-gaap_FairValueInputsLevel2Member_B6DA18EC3222D92CDF9DFB27970449D5" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_DC5294B0E49E21B360E4FB279704741D" xlink:to="loc_us-gaap_FairValueInputsLevel2Member_B6DA18EC3222D92CDF9DFB27970449D5" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FairValueInputsLevel3Member" xlink:label="loc_us-gaap_FairValueInputsLevel3Member_4C3AA9F127496BEF2503FB2797041C35" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_DC5294B0E49E21B360E4FB279704741D" xlink:to="loc_us-gaap_FairValueInputsLevel3Member_4C3AA9F127496BEF2503FB2797041C35" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FairValueByMeasurementBasisAxis" xlink:label="loc_us-gaap_FairValueByMeasurementBasisAxis_B28E31118E7F13C19F26FB2797042DB5" xlink:type="locator" />
    <presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByBalanceSheetGroupingTable_B3C873865F77FE4103C8FB279704D390" xlink:to="loc_us-gaap_FairValueByMeasurementBasisAxis_B28E31118E7F13C19F26FB2797042DB5" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FairValueDisclosureItemAmountsDomain" xlink:label="loc_us-gaap_FairValueDisclosureItemAmountsDomain_02080794AA55A6ABBFACFB279704BBFC" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByMeasurementBasisAxis_B28E31118E7F13C19F26FB2797042DB5" xlink:to="loc_us-gaap_FairValueDisclosureItemAmountsDomain_02080794AA55A6ABBFACFB279704BBFC" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PortionAtFairValueFairValueDisclosureMember" xlink:label="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_1AFEC22C5A2DEB585B30FB279704371A" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosureItemAmountsDomain_02080794AA55A6ABBFACFB279704BBFC" xlink:to="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_1AFEC22C5A2DEB585B30FB279704371A" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_EstimateOfFairValueFairValueDisclosureMember" xlink:label="loc_us-gaap_EstimateOfFairValueFairValueDisclosureMember_18230B8F997F99C73231FB27970480BD" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosureItemAmountsDomain_02080794AA55A6ABBFACFB279704BBFC" xlink:to="loc_us-gaap_EstimateOfFairValueFairValueDisclosureMember_18230B8F997F99C73231FB27970480BD" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CarryingReportedAmountFairValueDisclosureMember" xlink:label="loc_us-gaap_CarryingReportedAmountFairValueDisclosureMember_6346B5B92138489CDAE3FB279704176D" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosureItemAmountsDomain_02080794AA55A6ABBFACFB279704BBFC" xlink:to="loc_us-gaap_CarryingReportedAmountFairValueDisclosureMember_6346B5B92138489CDAE3FB279704176D" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FinancialInstrumentAxis" xlink:label="loc_us-gaap_FinancialInstrumentAxis_802CFDFDC97A483966A9FB27970429FD" xlink:type="locator" />
    <presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByBalanceSheetGroupingTable_B3C873865F77FE4103C8FB279704D390" xlink:to="loc_us-gaap_FinancialInstrumentAxis_802CFDFDC97A483966A9FB27970429FD" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_20D5C3C447F1A9C532B9FB2797046E8F" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentAxis_802CFDFDC97A483966A9FB27970429FD" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_20D5C3C447F1A9C532B9FB2797046E8F" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_AvailableForSaleSecuritiesAmortizedCostMember" xlink:label="loc_lly_AvailableForSaleSecuritiesAmortizedCostMember_FA95182E8F47623618D8FB2797049505" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_20D5C3C447F1A9C532B9FB2797046E8F" xlink:to="loc_lly_AvailableForSaleSecuritiesAmortizedCostMember_FA95182E8F47623618D8FB2797049505" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DerivativeInstrumentRiskAxis" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_56221C71A19792428571FB2797040C53" xlink:type="locator" />
    <presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByBalanceSheetGroupingTable_B3C873865F77FE4103C8FB279704D390" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_56221C71A19792428571FB2797040C53" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DerivativeContractTypeDomain" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_B4D40838827C8A1C2CF7FB2797049140" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_56221C71A19792428571FB2797040C53" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_B4D40838827C8A1C2CF7FB2797049140" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_HedgedFixedRateDebtMember" xlink:label="loc_lly_HedgedFixedRateDebtMember_FC1DC00AE393DC9FF4CCFB2797042217" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_B4D40838827C8A1C2CF7FB2797049140" xlink:to="loc_lly_HedgedFixedRateDebtMember_FC1DC00AE393DC9FF4CCFB2797042217" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_EquityContractMember" xlink:label="loc_us-gaap_EquityContractMember_81397525C072D4FD9B4FFB279704B8A7" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_B4D40838827C8A1C2CF7FB2797049140" xlink:to="loc_us-gaap_EquityContractMember_81397525C072D4FD9B4FFB279704B8A7" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OtherContractMember" xlink:label="loc_us-gaap_OtherContractMember_E1F3A5BCDB92D96D3F9FFB2797048A47" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_B4D40838827C8A1C2CF7FB2797049140" xlink:to="loc_us-gaap_OtherContractMember_E1F3A5BCDB92D96D3F9FFB2797048A47" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_InterestRateContractMember" xlink:label="loc_us-gaap_InterestRateContractMember_B1FF0B315CBDAE8D5144FB2797047423" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_B4D40838827C8A1C2CF7FB2797049140" xlink:to="loc_us-gaap_InterestRateContractMember_B1FF0B315CBDAE8D5144FB2797047423" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_InterestRateSwapMember" xlink:label="loc_us-gaap_InterestRateSwapMember_A39D8FA4F5350178A67AFB279704935E" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InterestRateContractMember_B1FF0B315CBDAE8D5144FB2797047423" xlink:to="loc_us-gaap_InterestRateSwapMember_A39D8FA4F5350178A67AFB279704935E" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ForeignExchangeContractMember" xlink:label="loc_us-gaap_ForeignExchangeContractMember_4FA2E337C255F8981B8CFB279704E3C9" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_B4D40838827C8A1C2CF7FB2797049140" xlink:to="loc_us-gaap_ForeignExchangeContractMember_4FA2E337C255F8981B8CFB279704E3C9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_BalanceSheetLocationAxis" xlink:label="loc_us-gaap_BalanceSheetLocationAxis_A8CEC1FFEEA2DB1CB73CFB2797045913" xlink:type="locator" />
    <presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByBalanceSheetGroupingTable_B3C873865F77FE4103C8FB279704D390" xlink:to="loc_us-gaap_BalanceSheetLocationAxis_A8CEC1FFEEA2DB1CB73CFB2797045913" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_BalanceSheetLocationDomain" xlink:label="loc_us-gaap_BalanceSheetLocationDomain_5AFAD802183A23A89718FB27970430CC" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BalanceSheetLocationAxis_A8CEC1FFEEA2DB1CB73CFB2797045913" xlink:to="loc_us-gaap_BalanceSheetLocationDomain_5AFAD802183A23A89718FB27970430CC" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OtherAssetsMember" xlink:label="loc_us-gaap_OtherAssetsMember_7461BD028DA8719E6937FB279704127A" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BalanceSheetLocationDomain_5AFAD802183A23A89718FB27970430CC" xlink:to="loc_us-gaap_OtherAssetsMember_7461BD028DA8719E6937FB279704127A" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_33A7C014935ED39942AAFB279704D57E" xlink:type="locator" />
    <presentationArc order="11" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByBalanceSheetGroupingTable_B3C873865F77FE4103C8FB279704D390" xlink:to="loc_us-gaap_StatementLineItems_33A7C014935ED39942AAFB279704D57E" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AverageRemainingMaturityOfForeignCurrencyDerivatives1" xlink:label="loc_us-gaap_AverageRemainingMaturityOfForeignCurrencyDerivatives1_0A1A136D47EF53BEF168FB2797045E6E" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_33A7C014935ED39942AAFB279704D57E" xlink:to="loc_us-gaap_AverageRemainingMaturityOfForeignCurrencyDerivatives1_0A1A136D47EF53BEF168FB2797045E6E" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CommercialPaper" xlink:label="loc_us-gaap_CommercialPaper_958A051965452B8822F2FB2797041F61" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_33A7C014935ED39942AAFB279704D57E" xlink:to="loc_us-gaap_CommercialPaper_958A051965452B8822F2FB2797041F61" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_LossContingencyDamagesAwardedValue" xlink:label="loc_us-gaap_LossContingencyDamagesAwardedValue_08AC7037BD37E54352BFFB2797043D0E" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_33A7C014935ED39942AAFB279704D57E" xlink:to="loc_us-gaap_LossContingencyDamagesAwardedValue_08AC7037BD37E54352BFFB2797043D0E" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DerivativeLiabilityNotionalAmount" xlink:label="loc_us-gaap_DerivativeLiabilityNotionalAmount_15892FB1230DD5CB3761FB27970420C5" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_33A7C014935ED39942AAFB279704D57E" xlink:to="loc_us-gaap_DerivativeLiabilityNotionalAmount_15892FB1230DD5CB3761FB27970420C5" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DerivativeAssetNotionalAmount" xlink:label="loc_us-gaap_DerivativeAssetNotionalAmount_9AE7D114E91947D989C1FB279704EC0F" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_33A7C014935ED39942AAFB279704D57E" xlink:to="loc_us-gaap_DerivativeAssetNotionalAmount_9AE7D114E91947D989C1FB279704EC0F" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_PaymentsforProceedsfromHedgeOperatingActivities" xlink:label="loc_lly_PaymentsforProceedsfromHedgeOperatingActivities_B44642FFF74C2ECB6652FB279704D18D" xlink:type="locator" />
    <presentationArc order="6" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_33A7C014935ED39942AAFB279704D57E" xlink:to="loc_lly_PaymentsforProceedsfromHedgeOperatingActivities_B44642FFF74C2ECB6652FB279704D18D" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ProceedsFromSaleOfAvailableForSaleSecurities" xlink:label="loc_us-gaap_ProceedsFromSaleOfAvailableForSaleSecurities_B528EC40176087AFA065FB27970472DE" xlink:type="locator" />
    <presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_33A7C014935ED39942AAFB279704D57E" xlink:to="loc_us-gaap_ProceedsFromSaleOfAvailableForSaleSecurities_B528EC40176087AFA065FB27970472DE" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CashAndCashEquivalentsFairValueDisclosure" xlink:label="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_6C9E44949E4C0C40FFBDFB27970457DF" xlink:type="locator" />
    <presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_33A7C014935ED39942AAFB279704D57E" xlink:to="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_6C9E44949E4C0C40FFBDFB27970457DF" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_LongTermDebt" xlink:label="loc_us-gaap_LongTermDebt_CDCF61658C3CCC8A5174FB2797049D58" xlink:type="locator" />
    <presentationArc order="9" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_33A7C014935ED39942AAFB279704D57E" xlink:to="loc_us-gaap_LongTermDebt_CDCF61658C3CCC8A5174FB2797049D58" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DerivativeAssetsCurrent" xlink:label="loc_us-gaap_DerivativeAssetsCurrent_1D1C2DF5FFC8C2423EEAFB279704D8B1" xlink:type="locator" />
    <presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_33A7C014935ED39942AAFB279704D57E" xlink:to="loc_us-gaap_DerivativeAssetsCurrent_1D1C2DF5FFC8C2423EEAFB279704D8B1" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AvailableforsaleSecuritiesInUnrealizedLossPositionsQualitativeDisclosureOtherPercentageOfNonperformingAssets" xlink:label="loc_us-gaap_AvailableforsaleSecuritiesInUnrealizedLossPositionsQualitativeDisclosureOtherPercentageOfNonperformingAssets_A75D9A01AAC5058DD966FB27970420B3" xlink:type="locator" />
    <presentationArc order="11" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_33A7C014935ED39942AAFB279704D57E" xlink:to="loc_us-gaap_AvailableforsaleSecuritiesInUnrealizedLossPositionsQualitativeDisclosureOtherPercentageOfNonperformingAssets_A75D9A01AAC5058DD966FB27970420B3" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DebtInstrumentInterestRateStatedPercentage" xlink:label="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_39CD1AA3070F7436ECA3FB2797041489" xlink:type="locator" />
    <presentationArc order="12" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_33A7C014935ED39942AAFB279704D57E" xlink:to="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_39CD1AA3070F7436ECA3FB2797041489" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_MaximumRemainingMaturityOfForeignCurrencyDerivatives1" xlink:label="loc_us-gaap_MaximumRemainingMaturityOfForeignCurrencyDerivatives1_00AC9AC563CC172F9DC9FB279704CE88" xlink:type="locator" />
    <presentationArc order="13" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_33A7C014935ED39942AAFB279704D57E" xlink:to="loc_us-gaap_MaximumRemainingMaturityOfForeignCurrencyDerivatives1_00AC9AC563CC172F9DC9FB279704CE88" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_LongTermDebtPercentageBearingVariableInterestRate" xlink:label="loc_us-gaap_LongTermDebtPercentageBearingVariableInterestRate_94DCF0D10249D25F6E27FB2797047101" xlink:type="locator" />
    <presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_33A7C014935ED39942AAFB279704D57E" xlink:to="loc_us-gaap_LongTermDebtPercentageBearingVariableInterestRate_94DCF0D10249D25F6E27FB2797047101" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ChangeInUnrealizedGainLossOnHedgedItemInFairValueHedge1" xlink:label="loc_us-gaap_ChangeInUnrealizedGainLossOnHedgedItemInFairValueHedge1_B05773EDF0C50346B0D4FB2797043190" xlink:type="locator" />
    <presentationArc order="15" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_33A7C014935ED39942AAFB279704D57E" xlink:to="loc_us-gaap_ChangeInUnrealizedGainLossOnHedgedItemInFairValueHedge1_B05773EDF0C50346B0D4FB2797043190" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ChangeInUnrealizedGainLossOnFairValueHedgingInstruments1" xlink:label="loc_us-gaap_ChangeInUnrealizedGainLossOnFairValueHedgingInstruments1_92D6F6070ACA203DA436FB279704AF0C" xlink:type="locator" />
    <presentationArc order="16" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_33A7C014935ED39942AAFB279704D57E" xlink:to="loc_us-gaap_ChangeInUnrealizedGainLossOnFairValueHedgingInstruments1_92D6F6070ACA203DA436FB279704AF0C" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_InterestRateCashFlowHedgeGainLossToBeReclassifiedDuringNext12MonthsNet" xlink:label="loc_us-gaap_InterestRateCashFlowHedgeGainLossToBeReclassifiedDuringNext12MonthsNet_43190EC0335DED9299A5FB279704FA75" xlink:type="locator" />
    <presentationArc order="17" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_33A7C014935ED39942AAFB279704D57E" xlink:to="loc_us-gaap_InterestRateCashFlowHedgeGainLossToBeReclassifiedDuringNext12MonthsNet_43190EC0335DED9299A5FB279704FA75" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DerivativeInstrumentsLossReclassifiedFromAccumulatedOCIIntoIncomeEffectivePortion" xlink:label="loc_us-gaap_DerivativeInstrumentsLossReclassifiedFromAccumulatedOCIIntoIncomeEffectivePortion_869BB6043E68D766BF98FB2797045F7B" xlink:type="locator" />
    <presentationArc order="18" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_33A7C014935ED39942AAFB279704D57E" xlink:to="loc_us-gaap_DerivativeInstrumentsLossReclassifiedFromAccumulatedOCIIntoIncomeEffectivePortion_869BB6043E68D766BF98FB2797045F7B" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_GainLossOnForeignCurrencyDerivativeInstrumentsNotDesignatedAsHedgingInstruments" xlink:label="loc_us-gaap_GainLossOnForeignCurrencyDerivativeInstrumentsNotDesignatedAsHedgingInstruments_6BC6BDD96BF614256317FB279704F0E7" xlink:type="locator" />
    <presentationArc order="19" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_33A7C014935ED39942AAFB279704D57E" xlink:to="loc_us-gaap_GainLossOnForeignCurrencyDerivativeInstrumentsNotDesignatedAsHedgingInstruments_6BC6BDD96BF614256317FB279704F0E7" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DerivativeInstrumentsGainLossRecognizedInOtherComprehensiveIncomeEffectivePortionNet" xlink:label="loc_us-gaap_DerivativeInstrumentsGainLossRecognizedInOtherComprehensiveIncomeEffectivePortionNet_9219207A9C05F3608768FB279704DB4E" xlink:type="locator" />
    <presentationArc order="20" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_33A7C014935ED39942AAFB279704D57E" xlink:to="loc_us-gaap_DerivativeInstrumentsGainLossRecognizedInOtherComprehensiveIncomeEffectivePortionNet_9219207A9C05F3608768FB279704DB4E" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DerivativeAssetsNoncurrent" xlink:label="loc_us-gaap_DerivativeAssetsNoncurrent_CE7767318ED0628D2468FB279704A9EB" xlink:type="locator" />
    <presentationArc order="21" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_33A7C014935ED39942AAFB279704D57E" xlink:to="loc_us-gaap_DerivativeAssetsNoncurrent_CE7767318ED0628D2468FB279704A9EB" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DerivativeLiabilitiesNoncurrent" xlink:label="loc_us-gaap_DerivativeLiabilitiesNoncurrent_66BD821B765CA37CA132FB2797043A85" xlink:type="locator" />
    <presentationArc order="22" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_33A7C014935ED39942AAFB279704D57E" xlink:to="loc_us-gaap_DerivativeLiabilitiesNoncurrent_66BD821B765CA37CA132FB2797043A85" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DerivativeLiabilitiesCurrent" xlink:label="loc_us-gaap_DerivativeLiabilitiesCurrent_2EA9A2BB21DB3DE8215FFB2797041835" xlink:type="locator" />
    <presentationArc order="23" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_33A7C014935ED39942AAFB279704D57E" xlink:to="loc_us-gaap_DerivativeLiabilitiesCurrent_2EA9A2BB21DB3DE8215FFB2797041835" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_BusinessCombinationContingentConsiderationLiabilityCurrent" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationLiabilityCurrent_064C89F86B88CAEDC36BFB2797046194" xlink:type="locator" />
    <presentationArc order="24" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_33A7C014935ED39942AAFB279704D57E" xlink:to="loc_us-gaap_BusinessCombinationContingentConsiderationLiabilityCurrent_064C89F86B88CAEDC36BFB2797046194" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_BusinessCombinationContingentConsiderationLiabilityNoncurrent" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationLiabilityNoncurrent_30CD3BB27190CC4EA8CAFB279704B054" xlink:type="locator" />
    <presentationArc order="25" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_33A7C014935ED39942AAFB279704D57E" xlink:to="loc_us-gaap_BusinessCombinationContingentConsiderationLiabilityNoncurrent_30CD3BB27190CC4EA8CAFB279704B054" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_AvailableForSaleSecuritiesContinuousUnrealizedGainPositionFairValue" xlink:label="loc_lly_AvailableForSaleSecuritiesContinuousUnrealizedGainPositionFairValue_46D8D3E373A6C356F3A7FB279704BCA2" xlink:type="locator" />
    <presentationArc order="26" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_33A7C014935ED39942AAFB279704D57E" xlink:to="loc_lly_AvailableForSaleSecuritiesContinuousUnrealizedGainPositionFairValue_46D8D3E373A6C356F3A7FB279704BCA2" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionFairValue" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionFairValue_AAB2612258F0064C0F02FB279704F652" xlink:type="locator" />
    <presentationArc order="27" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_33A7C014935ED39942AAFB279704D57E" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionFairValue_AAB2612258F0064C0F02FB279704F652" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ImpairmentOfInvestments" xlink:label="loc_us-gaap_ImpairmentOfInvestments_94E1C1D7CF7A2D155376FB2797040143" xlink:type="locator" />
    <presentationArc order="28" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_33A7C014935ED39942AAFB279704D57E" xlink:to="loc_us-gaap_ImpairmentOfInvestments_94E1C1D7CF7A2D155376FB2797040143" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AvailableForSaleSecuritiesAccumulatedGrossUnrealizedLossBeforeTax" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_FCD196E0364E50C6576FFB2797043386" xlink:type="locator" />
    <presentationArc order="29" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_33A7C014935ED39942AAFB279704D57E" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_FCD196E0364E50C6576FFB2797043386" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AvailableForSaleSecuritiesAccumulatedGrossUnrealizedGainBeforeTax" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_B49477AB1E773E4A4860FB27970488D4" xlink:type="locator" />
    <presentationArc order="30" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_33A7C014935ED39942AAFB279704D57E" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_B49477AB1E773E4A4860FB27970488D4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AvailableForSaleSecuritiesGrossRealizedGains" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesGrossRealizedGains_F3616446DDA61135E6E5FB279704B064" xlink:type="locator" />
    <presentationArc order="31" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_33A7C014935ED39942AAFB279704D57E" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesGrossRealizedGains_F3616446DDA61135E6E5FB279704B064" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AvailableForSaleSecuritiesGrossRealizedLosses" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesGrossRealizedLosses_0D86090E40182773CE5FFB279704462F" xlink:type="locator" />
    <presentationArc order="32" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_33A7C014935ED39942AAFB279704D57E" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesGrossRealizedLosses_0D86090E40182773CE5FFB279704462F" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AvailableForSaleSecuritiesCurrentAbstract" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesCurrentAbstract_D565B4852315664BA661FB27970402B4" xlink:type="locator" />
    <presentationArc order="33" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_33A7C014935ED39942AAFB279704D57E" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesCurrentAbstract_D565B4852315664BA661FB27970402B4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent_390D9206D251383051C9FB279704F10B" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesCurrentAbstract_D565B4852315664BA661FB27970402B4" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent_390D9206D251383051C9FB279704F10B" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AvailableForSaleSecuritiesCurrent" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesCurrent_03C654C3A59AA89B701BFB279704C301" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesCurrentAbstract_D565B4852315664BA661FB27970402B4" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesCurrent_03C654C3A59AA89B701BFB279704C301" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AvailableForSaleSecuritiesNoncurrentAbstract" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesNoncurrentAbstract_1776D5283760CC42A4A1FB27970492C1" xlink:type="locator" />
    <presentationArc order="34" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_33A7C014935ED39942AAFB279704D57E" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesNoncurrentAbstract_1776D5283760CC42A4A1FB27970492C1" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecuritiesNoncurrent" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesNoncurrent_3D16F5A820D39E0E5E4CFB279704F45F" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesNoncurrentAbstract_1776D5283760CC42A4A1FB27970492C1" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesNoncurrent_3D16F5A820D39E0E5E4CFB279704F45F" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AvailableForSaleSecuritiesEquitySecuritiesNoncurrent" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesEquitySecuritiesNoncurrent_915071BB30C87DB5DC05FB279704BCED" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesNoncurrentAbstract_1776D5283760CC42A4A1FB27970492C1" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesEquitySecuritiesNoncurrent_915071BB30C87DB5DC05FB279704BCED" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OtherLongTermInvestments" xlink:label="loc_us-gaap_OtherLongTermInvestments_7A6795C11BCD76409442FB279704501F" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesNoncurrentAbstract_1776D5283760CC42A4A1FB27970492C1" xlink:to="loc_us-gaap_OtherLongTermInvestments_7A6795C11BCD76409442FB279704501F" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AvailableForSaleSecuritiesNoncurrent" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesNoncurrent_3A249D5F4F56D7CE3D14FB2797040800" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesNoncurrentAbstract_1776D5283760CC42A4A1FB27970492C1" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesNoncurrent_3A249D5F4F56D7CE3D14FB2797040800" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearFairValue" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearFairValue_224F811D004C81D4315FFB2797042F75" xlink:type="locator" />
    <presentationArc order="35" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_33A7C014935ED39942AAFB279704D57E" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearFairValue_224F811D004C81D4315FFB2797042F75" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsFairValue" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsFairValue_260BA7B702CCADCD4DF1FB2797041381" xlink:type="locator" />
    <presentationArc order="36" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_33A7C014935ED39942AAFB279704D57E" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsFairValue_260BA7B702CCADCD4DF1FB2797041381" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterFiveThroughTenYearsFairValue" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterFiveThroughTenYearsFairValue_BE99CBBAD2B89DFBF1D2FB27970445DC" xlink:type="locator" />
    <presentationArc order="37" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_33A7C014935ED39942AAFB279704D57E" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterFiveThroughTenYearsFairValue_BE99CBBAD2B89DFBF1D2FB27970445DC" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterTenYearsFairValue" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterTenYearsFairValue_55DD6B04D5E7B4899B6DFB279704BF53" xlink:type="locator" />
    <presentationArc order="38" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_33A7C014935ED39942AAFB279704D57E" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterTenYearsFairValue_55DD6B04D5E7B4899B6DFB279704BF53" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_4B8C1D948E0ED4DCB39AFB27970440C7" xlink:type="locator" />
    <presentationArc order="39" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_33A7C014935ED39942AAFB279704D57E" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_4B8C1D948E0ED4DCB39AFB27970440C7" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_TranslationAdjustmentFunctionalToReportingCurrencyIncreaseDecreaseGrossOfTax" xlink:label="loc_us-gaap_TranslationAdjustmentFunctionalToReportingCurrencyIncreaseDecreaseGrossOfTax_1BA1F723623FA4648A28FB279704F8CD" xlink:type="locator" />
    <presentationArc order="40" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_33A7C014935ED39942AAFB279704D57E" xlink:to="loc_us-gaap_TranslationAdjustmentFunctionalToReportingCurrencyIncreaseDecreaseGrossOfTax_1BA1F723623FA4648A28FB279704F8CD" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.lilly.com/role/FinancialInstrumentsPolicies" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract" xlink:label="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_254577C9F7F118E69F84EB6618DA696C" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ConcentrationRiskCreditRisk" xlink:label="loc_us-gaap_ConcentrationRiskCreditRisk_E564D66836E6A76C1235EB661CA56632" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_254577C9F7F118E69F84EB6618DA696C" xlink:to="loc_us-gaap_ConcentrationRiskCreditRisk_E564D66836E6A76C1235EB661CA56632" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DerivativesPolicyTextBlock" xlink:label="loc_us-gaap_DerivativesPolicyTextBlock_D7E779F25A7959BE5C3DEB6618DA6FBF" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_254577C9F7F118E69F84EB6618DA696C" xlink:to="loc_us-gaap_DerivativesPolicyTextBlock_D7E779F25A7959BE5C3DEB6618DA6FBF" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CashAndCashEquivalentsPolicyTextBlock" xlink:label="loc_us-gaap_CashAndCashEquivalentsPolicyTextBlock_18699C245391A5E1FA76EB6618DA3F20" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_254577C9F7F118E69F84EB6618DA696C" xlink:to="loc_us-gaap_CashAndCashEquivalentsPolicyTextBlock_18699C245391A5E1FA76EB6618DA3F20" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_InvestmentPolicyTextBlock" xlink:label="loc_us-gaap_InvestmentPolicyTextBlock_FAF8EACE4D235E36252CEB6618DB6755" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_254577C9F7F118E69F84EB6618DA696C" xlink:to="loc_us-gaap_InvestmentPolicyTextBlock_FAF8EACE4D235E36252CEB6618DB6755" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.lilly.com/role/FinancialInstrumentsTables" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract" xlink:label="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_B0BAAC3784407A0FD388F6A272F89C22" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScheduleOfCashFlowHedgesIncludedInAccumulatedOtherComprehensiveIncomeLossTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfCashFlowHedgesIncludedInAccumulatedOtherComprehensiveIncomeLossTableTextBlock_5D333D1452C139D836E6F5374A43D7DA" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_B0BAAC3784407A0FD388F6A272F89C22" xlink:to="loc_us-gaap_ScheduleOfCashFlowHedgesIncludedInAccumulatedOtherComprehensiveIncomeLossTableTextBlock_5D333D1452C139D836E6F5374A43D7DA" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FairValueAssetsMeasuredOnRecurringAndNonrecurringBasisTableTextBlock" xlink:label="loc_us-gaap_FairValueAssetsMeasuredOnRecurringAndNonrecurringBasisTableTextBlock_0D8BD191EBF326A44B98F5374A430608" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_B0BAAC3784407A0FD388F6A272F89C22" xlink:to="loc_us-gaap_FairValueAssetsMeasuredOnRecurringAndNonrecurringBasisTableTextBlock_0D8BD191EBF326A44B98F5374A430608" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScheduleOfDerivativesInstrumentsStatementsOfFinancialPerformanceAndFinancialPositionLocationTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfDerivativesInstrumentsStatementsOfFinancialPerformanceAndFinancialPositionLocationTableTextBlock_88F08E9AFAAC8D9663A7F5374A43D4ED" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_B0BAAC3784407A0FD388F6A272F89C22" xlink:to="loc_us-gaap_ScheduleOfDerivativesInstrumentsStatementsOfFinancialPerformanceAndFinancialPositionLocationTableTextBlock_88F08E9AFAAC8D9663A7F5374A43D4ED" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FairValueAssetsMeasuredOnRecurringBasisTextBlock" xlink:label="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisTextBlock_7170A33BCF9CA77A2409F5374A439047" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_B0BAAC3784407A0FD388F6A272F89C22" xlink:to="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisTextBlock_7170A33BCF9CA77A2409F5374A439047" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisTextBlock" xlink:label="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisTextBlock_75C1BA49EE3BD66C5F57F5374A438780" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_B0BAAC3784407A0FD388F6A272F89C22" xlink:to="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisTextBlock_75C1BA49EE3BD66C5F57F5374A438780" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FairValueByBalanceSheetGroupingTextBlock" xlink:label="loc_us-gaap_FairValueByBalanceSheetGroupingTextBlock_22039C59E175FC83F262F5374A434720" xlink:type="locator" />
    <presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_B0BAAC3784407A0FD388F6A272F89C22" xlink:to="loc_us-gaap_FairValueByBalanceSheetGroupingTextBlock_22039C59E175FC83F262F5374A434720" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AvailableForSaleSecuritiesTextBlock" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesTextBlock_FE07E8E69A6A4729D176F5374A431D57" xlink:type="locator" />
    <presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_B0BAAC3784407A0FD388F6A272F89C22" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesTextBlock_FE07E8E69A6A4729D176F5374A431D57" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_GainLossOnInvestmentsTextBlock" xlink:label="loc_us-gaap_GainLossOnInvestmentsTextBlock_EE59DBD75B02E99AAFA3F5374A435DAB" xlink:type="locator" />
    <presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_B0BAAC3784407A0FD388F6A272F89C22" xlink:to="loc_us-gaap_GainLossOnInvestmentsTextBlock_EE59DBD75B02E99AAFA3F5374A435DAB" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.lilly.com/role/GoodwillAndOtherIntangibles" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract" xlink:label="loc_us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract_4BE3D5673BE7FCA4DDA9FC036DD51313" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_GoodwillAndIntangibleAssetsDisclosureTextBlock" xlink:label="loc_us-gaap_GoodwillAndIntangibleAssetsDisclosureTextBlock_E7FB5D8B3DC2006D1538FC036DD5D856" xlink:type="locator" />
    <presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract_4BE3D5673BE7FCA4DDA9FC036DD51313" xlink:to="loc_us-gaap_GoodwillAndIntangibleAssetsDisclosureTextBlock_E7FB5D8B3DC2006D1538FC036DD5D856" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.lilly.com/role/GoodwillAndOtherIntangiblesDetails" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract" xlink:label="loc_us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract_F074C87F583BFED63289F5374A1E39AE" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable" xlink:label="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_A42E0C947FE4D820F493F5374A1E3ADC" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract_F074C87F583BFED63289F5374A1E39AE" xlink:to="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_A42E0C947FE4D820F493F5374A1E3ADC" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_RangeAxis" xlink:label="loc_us-gaap_RangeAxis_2CA698FF197BBF35DA83F5374A1EF582" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_A42E0C947FE4D820F493F5374A1E3ADC" xlink:to="loc_us-gaap_RangeAxis_2CA698FF197BBF35DA83F5374A1EF582" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_RangeMember" xlink:label="loc_us-gaap_RangeMember_8D115BAA116036C8130EF5374A1E9005" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RangeAxis_2CA698FF197BBF35DA83F5374A1EF582" xlink:to="loc_us-gaap_RangeMember_8D115BAA116036C8130EF5374A1E9005" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_MaximumMember" xlink:label="loc_us-gaap_MaximumMember_AE1C9831E19FE5FA5901F5374A1ECB84" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RangeMember_8D115BAA116036C8130EF5374A1E9005" xlink:to="loc_us-gaap_MaximumMember_AE1C9831E19FE5FA5901F5374A1ECB84" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_MinimumMember" xlink:label="loc_us-gaap_MinimumMember_314EE95C70DE67D58B2BF5374A1EC167" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RangeMember_8D115BAA116036C8130EF5374A1E9005" xlink:to="loc_us-gaap_MinimumMember_314EE95C70DE67D58B2BF5374A1EC167" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_AB49E0AB1809908F0221F5374A1ED038" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_A42E0C947FE4D820F493F5374A1E3ADC" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_AB49E0AB1809908F0221F5374A1ED038" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_031BCCE95B6214581741F5374A1E6160" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_AB49E0AB1809908F0221F5374A1ED038" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_031BCCE95B6214581741F5374A1E6160" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DevelopedTechnologyRightsMember" xlink:label="loc_us-gaap_DevelopedTechnologyRightsMember_0F8CBB3EEF4D12ECC431F5374A1EA757" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_031BCCE95B6214581741F5374A1E6160" xlink:to="loc_us-gaap_DevelopedTechnologyRightsMember_0F8CBB3EEF4D12ECC431F5374A1EA757" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OtherIntangibleAssetsMember" xlink:label="loc_us-gaap_OtherIntangibleAssetsMember_7D18B4270DE51EBEAF81F5374A1E1EC7" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_031BCCE95B6214581741F5374A1E6160" xlink:to="loc_us-gaap_OtherIntangibleAssetsMember_7D18B4270DE51EBEAF81F5374A1E1EC7" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis_9676865F68100EBC1D2BF5374A1E6BF6" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_A42E0C947FE4D820F493F5374A1E3ADC" xlink:to="loc_us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis_9676865F68100EBC1D2BF5374A1E6BF6" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain_639FF99776AFC205ACE3F5374A1EE2FB" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis_9676865F68100EBC1D2BF5374A1E6BF6" xlink:to="loc_us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain_639FF99776AFC205ACE3F5374A1EE2FB" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_InProcessResearchAndDevelopmentMember" xlink:label="loc_us-gaap_InProcessResearchAndDevelopmentMember_349DB383FC968B64055AF5374A1F18D6" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain_639FF99776AFC205ACE3F5374A1EE2FB" xlink:to="loc_us-gaap_InProcessResearchAndDevelopmentMember_349DB383FC968B64055AF5374A1F18D6" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_HumanPharmaceuticalProductsMember" xlink:label="loc_lly_HumanPharmaceuticalProductsMember_06614B9972F9747ABAC3F5374A1F92CB" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain_639FF99776AFC205ACE3F5374A1EE2FB" xlink:to="loc_lly_HumanPharmaceuticalProductsMember_06614B9972F9747ABAC3F5374A1F92CB" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_AnimalHealthProductsMember" xlink:label="loc_lly_AnimalHealthProductsMember_EC19E540FF708713FB21F5374A1FD257" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain_639FF99776AFC205ACE3F5374A1EE2FB" xlink:to="loc_lly_AnimalHealthProductsMember_EC19E540FF708713FB21F5374A1FD257" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_1E5CDF0C4C8A18977BF9F5374A1F3F03" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_A42E0C947FE4D820F493F5374A1E3ADC" xlink:to="loc_us-gaap_StatementLineItems_1E5CDF0C4C8A18977BF9F5374A1F3F03" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsGross" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsGross_0BD80299D5D66D76C2BAF5374A1F6D3E" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_1E5CDF0C4C8A18977BF9F5374A1F3F03" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsGross_0BD80299D5D66D76C2BAF5374A1F6D3E" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ImpairmentOfIntangibleAssetsFinitelived" xlink:label="loc_us-gaap_ImpairmentOfIntangibleAssetsFinitelived_580E793CD4DB717C6F65F5374A1FA81F" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_1E5CDF0C4C8A18977BF9F5374A1F3F03" xlink:to="loc_us-gaap_ImpairmentOfIntangibleAssetsFinitelived_580E793CD4DB717C6F65F5374A1FA81F" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetUsefulLife" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetUsefulLife_7A60C7774A8B4F1738B4F5374A1F03DF" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_1E5CDF0C4C8A18977BF9F5374A1F3F03" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetUsefulLife_7A60C7774A8B4F1738B4F5374A1F03DF" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_GoodwillImpairmentLoss" xlink:label="loc_us-gaap_GoodwillImpairmentLoss_A98DA6806207714F3DCDF5374A1F0E61" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_1E5CDF0C4C8A18977BF9F5374A1F3F03" xlink:to="loc_us-gaap_GoodwillImpairmentLoss_A98DA6806207714F3DCDF5374A1F0E61" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_Goodwill" xlink:label="loc_us-gaap_Goodwill_C61175983DEBA2ACF9E7F5374A1FFA62" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_1E5CDF0C4C8A18977BF9F5374A1F3F03" xlink:to="loc_us-gaap_Goodwill_C61175983DEBA2ACF9E7F5374A1FFA62" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill_842586F2B5B34730BB92F5374A1FEBB1" xlink:type="locator" />
    <presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_1E5CDF0C4C8A18977BF9F5374A1F3F03" xlink:to="loc_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill_842586F2B5B34730BB92F5374A1FEBB1" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_IntangibleAssetsGrossExcludingGoodwill" xlink:label="loc_us-gaap_IntangibleAssetsGrossExcludingGoodwill_10A633A6B054A302E50FF5374A1F96B5" xlink:type="locator" />
    <presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_1E5CDF0C4C8A18977BF9F5374A1F3F03" xlink:to="loc_us-gaap_IntangibleAssetsGrossExcludingGoodwill_10A633A6B054A302E50FF5374A1F96B5" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_88DAC388DB12ACBADC9DF5374A1FF314" xlink:type="locator" />
    <presentationArc order="8" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_1E5CDF0C4C8A18977BF9F5374A1F3F03" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_88DAC388DB12ACBADC9DF5374A1FF314" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_IntangibleAssetsNetExcludingGoodwill" xlink:label="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_C65F06ADA1560BCF639BF5374A1F6C7E" xlink:type="locator" />
    <presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_1E5CDF0C4C8A18977BF9F5374A1F3F03" xlink:to="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_C65F06ADA1560BCF639BF5374A1F6C7E" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsNet" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_76400E720B01F06C0D4EF5374A1F6A58" xlink:type="locator" />
    <presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_1E5CDF0C4C8A18977BF9F5374A1F3F03" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsNet_76400E720B01F06C0D4EF5374A1F6A58" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsRemainingAmortizationPeriod1" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsRemainingAmortizationPeriod1_6107976ED602D4BE3AFFF5374A1F6B13" xlink:type="locator" />
    <presentationArc order="11" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_1E5CDF0C4C8A18977BF9F5374A1F3F03" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsRemainingAmortizationPeriod1_6107976ED602D4BE3AFFF5374A1F6B13" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AmortizationOfIntangibleAssets" xlink:label="loc_us-gaap_AmortizationOfIntangibleAssets_CA19126048B4E39585FAF5374A1F476E" xlink:type="locator" />
    <presentationArc order="12" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_1E5CDF0C4C8A18977BF9F5374A1F3F03" xlink:to="loc_us-gaap_AmortizationOfIntangibleAssets_CA19126048B4E39585FAF5374A1F476E" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths_6E3DE360CD3BC6ADD46BF5374A1F8E48" xlink:type="locator" />
    <presentationArc order="13" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_1E5CDF0C4C8A18977BF9F5374A1F3F03" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths_6E3DE360CD3BC6ADD46BF5374A1F8E48" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo_E9EFABDEDE115AD07300F5374A1F7B1D" xlink:type="locator" />
    <presentationArc order="14" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_1E5CDF0C4C8A18977BF9F5374A1F3F03" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo_E9EFABDEDE115AD07300F5374A1F7B1D" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearThree" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearThree_22804E70EA54546CFE77F5374A200D5D" xlink:type="locator" />
    <presentationArc order="15" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_1E5CDF0C4C8A18977BF9F5374A1F3F03" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearThree_22804E70EA54546CFE77F5374A200D5D" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFour" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFour_A3A17257E3EAE6A0CF59F5374A20FF14" xlink:type="locator" />
    <presentationArc order="16" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_1E5CDF0C4C8A18977BF9F5374A1F3F03" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFour_A3A17257E3EAE6A0CF59F5374A20FF14" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFive" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFive_5763A84818DCB3B85362F5374A20A4EC" xlink:type="locator" />
    <presentationArc order="17" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_1E5CDF0C4C8A18977BF9F5374A1F3F03" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFive_5763A84818DCB3B85362F5374A20A4EC" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_IndefiniteLivedIntangibleAssetsGross" xlink:label="loc_lly_IndefiniteLivedIntangibleAssetsGross_EA17A8C0F411AE250A29F5374A20D6EB" xlink:type="locator" />
    <presentationArc order="18" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_1E5CDF0C4C8A18977BF9F5374A1F3F03" xlink:to="loc_lly_IndefiniteLivedIntangibleAssetsGross_EA17A8C0F411AE250A29F5374A20D6EB" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.lilly.com/role/GoodwillAndOtherIntangiblesGoodwillAndOtherIntangiblesPolicies" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract" xlink:label="loc_us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract_C8CC9EE0FB958CC869BCFC03707350E7" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_GoodwillAndIntangibleAssetsPolicyTextBlock" xlink:label="loc_us-gaap_GoodwillAndIntangibleAssetsPolicyTextBlock_9870D2D4FEA7D60EE7B9FC037073EEFF" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract_C8CC9EE0FB958CC869BCFC03707350E7" xlink:to="loc_us-gaap_GoodwillAndIntangibleAssetsPolicyTextBlock_9870D2D4FEA7D60EE7B9FC037073EEFF" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.lilly.com/role/GoodwillAndOtherIntangiblesTables" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract" xlink:label="loc_us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract_3D94629A949E26C279CFCE72C79DEB06" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseTableTextBlock" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseTableTextBlock_6C93E5877EDD821CD912CE73F16428E2" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract_3D94629A949E26C279CFCE72C79DEB06" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseTableTextBlock_6C93E5877EDD821CD912CE73F16428E2" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScheduleOfIntangibleAssetsAndGoodwillTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfIntangibleAssetsAndGoodwillTableTextBlock_918DF75A943799AF358ECE72C79ECB6B" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract_3D94629A949E26C279CFCE72C79DEB06" xlink:to="loc_us-gaap_ScheduleOfIntangibleAssetsAndGoodwillTableTextBlock_918DF75A943799AF358ECE72C79ECB6B" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTableTextBlock_A15F20950216C611BBE9CE72C7A3B0DD" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract_3D94629A949E26C279CFCE72C79DEB06" xlink:to="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTableTextBlock_A15F20950216C611BBE9CE72C7A3B0DD" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScheduleofFiniteLivedIntangibleAssetsFutureAmortizationExpenseTableTextBlock" xlink:label="loc_us-gaap_ScheduleofFiniteLivedIntangibleAssetsFutureAmortizationExpenseTableTextBlock_942685728941B8243783CE7497E025D5" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract_3D94629A949E26C279CFCE72C79DEB06" xlink:to="loc_us-gaap_ScheduleofFiniteLivedIntangibleAssetsFutureAmortizationExpenseTableTextBlock_942685728941B8243783CE7497E025D5" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.lilly.com/role/ImplementationOfNewFinancialAccountingPronouncements" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_NewAccountingPronouncementsAndChangesInAccountingPrinciplesAbstract" xlink:label="loc_us-gaap_NewAccountingPronouncementsAndChangesInAccountingPrinciplesAbstract_0B518F1842C699CD0337D7132AE9BE7E" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_NewAccountingPronouncementsAndChangesInAccountingPrinciplesTextBlock" xlink:label="loc_us-gaap_NewAccountingPronouncementsAndChangesInAccountingPrinciplesTextBlock_0675C8B957E925F80F7AD7132AE9E3BF" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsAndChangesInAccountingPrinciplesAbstract_0B518F1842C699CD0337D7132AE9BE7E" xlink:to="loc_us-gaap_NewAccountingPronouncementsAndChangesInAccountingPrinciplesTextBlock_0675C8B957E925F80F7AD7132AE9E3BF" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.lilly.com/role/ImplementationOfNewFinancialAccountingPronouncementsDetails" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_NewAccountingPronouncementsAndChangesInAccountingPrinciplesAbstract" xlink:label="loc_us-gaap_NewAccountingPronouncementsAndChangesInAccountingPrinciplesAbstract_0DE64FA8DDCAD3AB4746F5374ADC5F3F" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_NewAccountingPronouncementEarlyAdoptionTable" xlink:label="loc_us-gaap_NewAccountingPronouncementEarlyAdoptionTable_0B7F5E3781E8A6C27FEDF5374ADCA992" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsAndChangesInAccountingPrinciplesAbstract_0DE64FA8DDCAD3AB4746F5374ADC5F3F" xlink:to="loc_us-gaap_NewAccountingPronouncementEarlyAdoptionTable_0B7F5E3781E8A6C27FEDF5374ADCA992" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_NewAccountingPronouncementEarlyAdoptionAxis" xlink:label="loc_us-gaap_NewAccountingPronouncementEarlyAdoptionAxis_1974C30F6CD38D5BA369F5374ADDB47E" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementEarlyAdoptionTable_0B7F5E3781E8A6C27FEDF5374ADCA992" xlink:to="loc_us-gaap_NewAccountingPronouncementEarlyAdoptionAxis_1974C30F6CD38D5BA369F5374ADDB47E" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_NewAccountingPrinciplesEarlyAdoptionMember" xlink:label="loc_us-gaap_NewAccountingPrinciplesEarlyAdoptionMember_6EA2E7115DE14A2CF50EF5374ADD7EEC" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementEarlyAdoptionAxis_1974C30F6CD38D5BA369F5374ADDB47E" xlink:to="loc_us-gaap_NewAccountingPrinciplesEarlyAdoptionMember_6EA2E7115DE14A2CF50EF5374ADD7EEC" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_NewAccountingPronouncementEarlyAdoptionEffectMember" xlink:label="loc_us-gaap_NewAccountingPronouncementEarlyAdoptionEffectMember_3237758A1F3287F941CFF5374ADDC412" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPrinciplesEarlyAdoptionMember_6EA2E7115DE14A2CF50EF5374ADD7EEC" xlink:to="loc_us-gaap_NewAccountingPronouncementEarlyAdoptionEffectMember_3237758A1F3287F941CFF5374ADDC412" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_NewAccountingPronouncementEarlyAdoptionLineItems" xlink:label="loc_us-gaap_NewAccountingPronouncementEarlyAdoptionLineItems_A49EE9A610CB38F6B257F5374ADD4103" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementEarlyAdoptionTable_0B7F5E3781E8A6C27FEDF5374ADCA992" xlink:to="loc_us-gaap_NewAccountingPronouncementEarlyAdoptionLineItems_A49EE9A610CB38F6B257F5374ADD4103" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets" xlink:label="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_10DB84122271DA376876F5C515A9E79A" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementEarlyAdoptionLineItems_A49EE9A610CB38F6B257F5374ADD4103" xlink:to="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_10DB84122271DA376876F5C515A9E79A" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_IncreaseDecreaseInOtherNoncurrentAssets" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherNoncurrentAssets_5371F0007C5B46E8DCA1F596D532924F" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementEarlyAdoptionLineItems_A49EE9A610CB38F6B257F5374ADD4103" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherNoncurrentAssets_5371F0007C5B46E8DCA1F596D532924F" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_IncreaseDecreaseInOtherDeferredLiability" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherDeferredLiability_EEFCC75B34F98F87414BF5A60DF7168C" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementEarlyAdoptionLineItems_A49EE9A610CB38F6B257F5374ADD4103" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherDeferredLiability_EEFCC75B34F98F87414BF5A60DF7168C" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_IncreaseDecreaseInOtherNoncurrentLiabilities" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherNoncurrentLiabilities_A720B667C14F85E37893F5A72AC312FA" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementEarlyAdoptionLineItems_A49EE9A610CB38F6B257F5374ADD4103" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherNoncurrentLiabilities_A720B667C14F85E37893F5A72AC312FA" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.lilly.com/role/ImplementationOfNewFinancialAccountingPronouncementsImplementationOfNewFinancialAccountingPronouncementsTables" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_NewAccountingPronouncementsAndChangesInAccountingPrinciplesAbstract" xlink:label="loc_us-gaap_NewAccountingPronouncementsAndChangesInAccountingPrinciplesAbstract_823EA6206603C02027F5F5374ADF0B29" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_NewAccountingPronouncementEarlyAdoptionTable" xlink:label="loc_us-gaap_NewAccountingPronouncementEarlyAdoptionTable_F7B476A6F1DA2884533CF5D39AE7118F" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsAndChangesInAccountingPrinciplesAbstract_823EA6206603C02027F5F5374ADF0B29" xlink:to="loc_us-gaap_NewAccountingPronouncementEarlyAdoptionTable_F7B476A6F1DA2884533CF5D39AE7118F" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_NewAccountingPronouncementEarlyAdoptionAxis" xlink:label="loc_us-gaap_NewAccountingPronouncementEarlyAdoptionAxis_917744A2399FD50933C8F5D39AE9F420" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementEarlyAdoptionTable_F7B476A6F1DA2884533CF5D39AE7118F" xlink:to="loc_us-gaap_NewAccountingPronouncementEarlyAdoptionAxis_917744A2399FD50933C8F5D39AE9F420" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_NewAccountingPrinciplesEarlyAdoptionMember" xlink:label="loc_us-gaap_NewAccountingPrinciplesEarlyAdoptionMember_11C56ABC299D0AFFDC32F5D39AE96191" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementEarlyAdoptionAxis_917744A2399FD50933C8F5D39AE9F420" xlink:to="loc_us-gaap_NewAccountingPrinciplesEarlyAdoptionMember_11C56ABC299D0AFFDC32F5D39AE96191" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_NewAccountingPronouncementEarlyAdoptionLineItems" xlink:label="loc_us-gaap_NewAccountingPronouncementEarlyAdoptionLineItems_942F6C856B84C255BE8AF5D501A26C8C" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementEarlyAdoptionTable_F7B476A6F1DA2884533CF5D39AE7118F" xlink:to="loc_us-gaap_NewAccountingPronouncementEarlyAdoptionLineItems_942F6C856B84C255BE8AF5D501A26C8C" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_NewAccountingPronouncementEarlyAdoptionTableTextBlock" xlink:label="loc_us-gaap_NewAccountingPronouncementEarlyAdoptionTableTextBlock_04AF30B602F12824E1A0F5D58BA7DBD4" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementEarlyAdoptionLineItems_942F6C856B84C255BE8AF5D501A26C8C" xlink:to="loc_us-gaap_NewAccountingPronouncementEarlyAdoptionTableTextBlock_04AF30B602F12824E1A0F5D58BA7DBD4" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.lilly.com/role/IncomeTaxes" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_IncomeTaxDisclosureAbstract" xlink:label="loc_us-gaap_IncomeTaxDisclosureAbstract_BCE8B7CE4771544A6E5EF13B6103F173" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScheduleOfComponentsOfIncomeTaxExpenseBenefitTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfComponentsOfIncomeTaxExpenseBenefitTableTextBlock_4500D4118A435CC593C4F13B6378AA71" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_BCE8B7CE4771544A6E5EF13B6103F173" xlink:to="loc_us-gaap_ScheduleOfComponentsOfIncomeTaxExpenseBenefitTableTextBlock_4500D4118A435CC593C4F13B6378AA71" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.lilly.com/role/IncomeTaxesCompositionAndDeferredsDetails" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_IncomeTaxDisclosureAbstract" xlink:label="loc_us-gaap_IncomeTaxDisclosureAbstract_0198A2A69F8284756BBDF53749C67962" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FederalIncomeTaxNoteTable" xlink:label="loc_us-gaap_FederalIncomeTaxNoteTable_68F2DA8EF623DE442492F53749C7E436" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_0198A2A69F8284756BBDF53749C67962" xlink:to="loc_us-gaap_FederalIncomeTaxNoteTable_68F2DA8EF623DE442492F53749C7E436" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_IncomeTaxAuthorityAxis" xlink:label="loc_us-gaap_IncomeTaxAuthorityAxis_E90DCFF572C577D4D5DBF53749C786A3" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FederalIncomeTaxNoteTable_68F2DA8EF623DE442492F53749C7E436" xlink:to="loc_us-gaap_IncomeTaxAuthorityAxis_E90DCFF572C577D4D5DBF53749C786A3" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_IncomeTaxAuthorityDomain" xlink:label="loc_us-gaap_IncomeTaxAuthorityDomain_EFC46F9A73E674F7CACAF53749C7FE03" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxAuthorityAxis_E90DCFF572C577D4D5DBF53749C786A3" xlink:to="loc_us-gaap_IncomeTaxAuthorityDomain_EFC46F9A73E674F7CACAF53749C7FE03" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_InternalRevenueServiceIRSMember" xlink:label="loc_us-gaap_InternalRevenueServiceIRSMember_6E662C6454721380CC22F53749C79988" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxAuthorityDomain_EFC46F9A73E674F7CACAF53749C7FE03" xlink:to="loc_us-gaap_InternalRevenueServiceIRSMember_6E662C6454721380CC22F53749C79988" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StateAndLocalJurisdictionMember" xlink:label="loc_us-gaap_StateAndLocalJurisdictionMember_421F24E9BCEE839C2AEAF53749C7E77A" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxAuthorityDomain_EFC46F9A73E674F7CACAF53749C7FE03" xlink:to="loc_us-gaap_StateAndLocalJurisdictionMember_421F24E9BCEE839C2AEAF53749C7E77A" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ForeignCountryMember" xlink:label="loc_us-gaap_ForeignCountryMember_751B755D16A76F256675F53749C7D19E" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxAuthorityDomain_EFC46F9A73E674F7CACAF53749C7FE03" xlink:to="loc_us-gaap_ForeignCountryMember_751B755D16A76F256675F53749C7D19E" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_TaxCreditCarryforwardAxis" xlink:label="loc_us-gaap_TaxCreditCarryforwardAxis_3B5AE9B6CB6DCA46E737F53749C79C7A" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FederalIncomeTaxNoteTable_68F2DA8EF623DE442492F53749C7E436" xlink:to="loc_us-gaap_TaxCreditCarryforwardAxis_3B5AE9B6CB6DCA46E737F53749C79C7A" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_TaxCreditCarryforwardNameDomain" xlink:label="loc_us-gaap_TaxCreditCarryforwardNameDomain_42428FCF94DD0899B273F53749C7AE2D" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TaxCreditCarryforwardAxis_3B5AE9B6CB6DCA46E737F53749C79C7A" xlink:to="loc_us-gaap_TaxCreditCarryforwardNameDomain_42428FCF94DD0899B273F53749C7AE2D" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_CarryforwardMember" xlink:label="loc_lly_CarryforwardMember_B50B9FE61A01AC5C3B31F53749C7F85F" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TaxCreditCarryforwardNameDomain_42428FCF94DD0899B273F53749C7AE2D" xlink:to="loc_lly_CarryforwardMember_B50B9FE61A01AC5C3B31F53749C7F85F" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_CarrybackMember" xlink:label="loc_lly_CarrybackMember_99627B96344BC4F26DD3F53749C7C9A2" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TaxCreditCarryforwardNameDomain_42428FCF94DD0899B273F53749C7AE2D" xlink:to="loc_lly_CarrybackMember_99627B96344BC4F26DD3F53749C7C9A2" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_Expirationwithin5yearsMember" xlink:label="loc_lly_Expirationwithin5yearsMember_9EE6E67384F786E09ED1F53749C73543" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TaxCreditCarryforwardNameDomain_42428FCF94DD0899B273F53749C7AE2D" xlink:to="loc_lly_Expirationwithin5yearsMember_9EE6E67384F786E09ED1F53749C73543" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_Expiration5to20YearsMember" xlink:label="loc_lly_Expiration5to20YearsMember_B23DC608C25F8A37AEB6F53749C7CDAE" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TaxCreditCarryforwardNameDomain_42428FCF94DD0899B273F53749C7AE2D" xlink:to="loc_lly_Expiration5to20YearsMember_B23DC608C25F8A37AEB6F53749C7CDAE" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_Expiration5to20YearsMinimumMember" xlink:label="loc_lly_Expiration5to20YearsMinimumMember_8277CF8731D658B51A96F53749C7FACE" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lly_Expiration5to20YearsMember_B23DC608C25F8A37AEB6F53749C7CDAE" xlink:to="loc_lly_Expiration5to20YearsMinimumMember_8277CF8731D658B51A96F53749C7FACE" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_Expiration5to20YearsMaximumMember" xlink:label="loc_lly_Expiration5to20YearsMaximumMember_354BECF82CBD086F6BECF53749C7C575" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lly_Expiration5to20YearsMember_B23DC608C25F8A37AEB6F53749C7CDAE" xlink:to="loc_lly_Expiration5to20YearsMaximumMember_354BECF82CBD086F6BECF53749C7C575" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_Expiration2015to2021Member" xlink:label="loc_lly_Expiration2015to2021Member_50180F6164F2A5F21FE3F53749C7157D" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TaxCreditCarryforwardNameDomain_42428FCF94DD0899B273F53749C7AE2D" xlink:to="loc_lly_Expiration2015to2021Member_50180F6164F2A5F21FE3F53749C7157D" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_Expiration1020YearsMaximumMember" xlink:label="loc_lly_Expiration1020YearsMaximumMember_59C0A675DAF591631AADF53749C7D6C3" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lly_Expiration2015to2021Member_50180F6164F2A5F21FE3F53749C7157D" xlink:to="loc_lly_Expiration1020YearsMaximumMember_59C0A675DAF591631AADF53749C7D6C3" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_NoExpirationMember" xlink:label="loc_lly_NoExpirationMember_C7C25806715624336B7DF53749C831BF" xlink:type="locator" />
    <presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TaxCreditCarryforwardNameDomain_42428FCF94DD0899B273F53749C7AE2D" xlink:to="loc_lly_NoExpirationMember_C7C25806715624336B7DF53749C831BF" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_DesignatedUnusableMember" xlink:label="loc_lly_DesignatedUnusableMember_827838396A3EC39B773FF53749C87FE7" xlink:type="locator" />
    <presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TaxCreditCarryforwardNameDomain_42428FCF94DD0899B273F53749C7AE2D" xlink:to="loc_lly_DesignatedUnusableMember_827838396A3EC39B773FF53749C87FE7" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_477C0F73E88C5A745469F53749C81BD0" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FederalIncomeTaxNoteTable_68F2DA8EF623DE442492F53749C7E436" xlink:to="loc_us-gaap_StatementLineItems_477C0F73E88C5A745469F53749C81BD0" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_UndistributedEarningsOfForeignSubsidiaries" xlink:label="loc_us-gaap_UndistributedEarningsOfForeignSubsidiaries_A94E883914B7EFD9FEDFF53749C82E6A" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_477C0F73E88C5A745469F53749C81BD0" xlink:to="loc_us-gaap_UndistributedEarningsOfForeignSubsidiaries_A94E883914B7EFD9FEDFF53749C82E6A" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CurrentFederalTaxExpenseBenefit" xlink:label="loc_us-gaap_CurrentFederalTaxExpenseBenefit_5EC130A251B8BE7B257CF53749C8465C" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_477C0F73E88C5A745469F53749C81BD0" xlink:to="loc_us-gaap_CurrentFederalTaxExpenseBenefit_5EC130A251B8BE7B257CF53749C8465C" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CurrentForeignTaxExpenseBenefit" xlink:label="loc_us-gaap_CurrentForeignTaxExpenseBenefit_9F1275569513605E99F8F53749C885B3" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_477C0F73E88C5A745469F53749C81BD0" xlink:to="loc_us-gaap_CurrentForeignTaxExpenseBenefit_9F1275569513605E99F8F53749C885B3" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CurrentStateAndLocalTaxExpenseBenefit" xlink:label="loc_us-gaap_CurrentStateAndLocalTaxExpenseBenefit_1435CE1D511662CFEBC4F53749C82CA5" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_477C0F73E88C5A745469F53749C81BD0" xlink:to="loc_us-gaap_CurrentStateAndLocalTaxExpenseBenefit_1435CE1D511662CFEBC4F53749C82CA5" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CurrentIncomeTaxExpenseBenefit" xlink:label="loc_us-gaap_CurrentIncomeTaxExpenseBenefit_D1528D0E5B5111F47DE9F53749C8E11E" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_477C0F73E88C5A745469F53749C81BD0" xlink:to="loc_us-gaap_CurrentIncomeTaxExpenseBenefit_D1528D0E5B5111F47DE9F53749C8E11E" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DeferredFederalIncomeTaxExpenseBenefit" xlink:label="loc_us-gaap_DeferredFederalIncomeTaxExpenseBenefit_6E3C89FE463851A7A940F53749C84C46" xlink:type="locator" />
    <presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_477C0F73E88C5A745469F53749C81BD0" xlink:to="loc_us-gaap_DeferredFederalIncomeTaxExpenseBenefit_6E3C89FE463851A7A940F53749C84C46" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DeferredForeignIncomeTaxExpenseBenefit" xlink:label="loc_us-gaap_DeferredForeignIncomeTaxExpenseBenefit_8A8FC7A086712A65A34EF53749C85A4E" xlink:type="locator" />
    <presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_477C0F73E88C5A745469F53749C81BD0" xlink:to="loc_us-gaap_DeferredForeignIncomeTaxExpenseBenefit_8A8FC7A086712A65A34EF53749C85A4E" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DeferredStateAndLocalIncomeTaxExpenseBenefit" xlink:label="loc_us-gaap_DeferredStateAndLocalIncomeTaxExpenseBenefit_C87E81D89A83C2504067F53749C86443" xlink:type="locator" />
    <presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_477C0F73E88C5A745469F53749C81BD0" xlink:to="loc_us-gaap_DeferredStateAndLocalIncomeTaxExpenseBenefit_C87E81D89A83C2504067F53749C86443" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DeferredIncomeTaxExpenseBenefit" xlink:label="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_752FF844127F94CA5B96F53749C8CE30" xlink:type="locator" />
    <presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_477C0F73E88C5A745469F53749C81BD0" xlink:to="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_752FF844127F94CA5B96F53749C8CE30" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_IncomeTaxExpenseBenefit" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_68A16C99693F4EF94A3CF53749C8B20C" xlink:type="locator" />
    <presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_477C0F73E88C5A745469F53749C81BD0" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_68A16C99693F4EF94A3CF53749C8B20C" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefits" xlink:label="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefits_4596C9308FBF8B3F760BF53749C859DB" xlink:type="locator" />
    <presentationArc order="11" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_477C0F73E88C5A745469F53749C81BD0" xlink:to="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefits_4596C9308FBF8B3F760BF53749C859DB" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DeferredTaxAssetsTaxCreditCarryforwards" xlink:label="loc_us-gaap_DeferredTaxAssetsTaxCreditCarryforwards_3946B6210083A67C26FCF53749C8A7FF" xlink:type="locator" />
    <presentationArc order="12" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_477C0F73E88C5A745469F53749C81BD0" xlink:to="loc_us-gaap_DeferredTaxAssetsTaxCreditCarryforwards_3946B6210083A67C26FCF53749C8A7FF" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsReserves" xlink:label="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsReserves_BD1EE828B9FF08E81131F53749C80A9F" xlink:type="locator" />
    <presentationArc order="13" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_477C0F73E88C5A745469F53749C81BD0" xlink:to="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsReserves_BD1EE828B9FF08E81131F53749C80A9F" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DeferredTaxAssetsOtherComprehensiveLoss" xlink:label="loc_us-gaap_DeferredTaxAssetsOtherComprehensiveLoss_F862FE94C9DF938EF539F53749C846B1" xlink:type="locator" />
    <presentationArc order="14" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_477C0F73E88C5A745469F53749C81BD0" xlink:to="loc_us-gaap_DeferredTaxAssetsOtherComprehensiveLoss_F862FE94C9DF938EF539F53749C846B1" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DeferredTaxAssetsOperatingLossCarryforwards" xlink:label="loc_us-gaap_DeferredTaxAssetsOperatingLossCarryforwards_A0E1C774B9E35A741042F53749C8D634" xlink:type="locator" />
    <presentationArc order="15" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_477C0F73E88C5A745469F53749C81BD0" xlink:to="loc_us-gaap_DeferredTaxAssetsOperatingLossCarryforwards_A0E1C774B9E35A741042F53749C8D634" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DeferredTaxAssetsGoodwillAndIntangibleAssets" xlink:label="loc_us-gaap_DeferredTaxAssetsGoodwillAndIntangibleAssets_0941B7B55AE71439E6BDF53749C9F117" xlink:type="locator" />
    <presentationArc order="16" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_477C0F73E88C5A745469F53749C81BD0" xlink:to="loc_us-gaap_DeferredTaxAssetsGoodwillAndIntangibleAssets_0941B7B55AE71439E6BDF53749C9F117" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_DeferredTaxAssetFairValueAdjustments" xlink:label="loc_lly_DeferredTaxAssetFairValueAdjustments_EF0F929707141BE5623CF53749C9462C" xlink:type="locator" />
    <presentationArc order="17" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_477C0F73E88C5A745469F53749C81BD0" xlink:to="loc_lly_DeferredTaxAssetFairValueAdjustments_EF0F929707141BE5623CF53749C9462C" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsContingencies" xlink:label="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsContingencies_1281EBD4CDCB6F66A1CBF53749C9A346" xlink:type="locator" />
    <presentationArc order="18" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_477C0F73E88C5A745469F53749C81BD0" xlink:to="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsContingencies_1281EBD4CDCB6F66A1CBF53749C9A346" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DeferredTaxAssetsOther" xlink:label="loc_us-gaap_DeferredTaxAssetsOther_75212B7E3D794667051AF53749C900E8" xlink:type="locator" />
    <presentationArc order="19" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_477C0F73E88C5A745469F53749C81BD0" xlink:to="loc_us-gaap_DeferredTaxAssetsOther_75212B7E3D794667051AF53749C900E8" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DeferredTaxAssetsGross" xlink:label="loc_us-gaap_DeferredTaxAssetsGross_091521F7DFA922C4C7D0F53749C9C34F" xlink:type="locator" />
    <presentationArc order="20" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_477C0F73E88C5A745469F53749C81BD0" xlink:to="loc_us-gaap_DeferredTaxAssetsGross_091521F7DFA922C4C7D0F53749C9C34F" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DeferredTaxAssetsValuationAllowance" xlink:label="loc_us-gaap_DeferredTaxAssetsValuationAllowance_BB8E1A9563822F6E0C97F53749C96005" xlink:type="locator" />
    <presentationArc order="21" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_477C0F73E88C5A745469F53749C81BD0" xlink:to="loc_us-gaap_DeferredTaxAssetsValuationAllowance_BB8E1A9563822F6E0C97F53749C96005" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DeferredTaxAssetsNet" xlink:label="loc_us-gaap_DeferredTaxAssetsNet_66BA1F8D9432A26DD85EF53749C9DA0A" xlink:type="locator" />
    <presentationArc order="22" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_477C0F73E88C5A745469F53749C81BD0" xlink:to="loc_us-gaap_DeferredTaxAssetsNet_66BA1F8D9432A26DD85EF53749C9DA0A" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DeferredTaxLiabilitiesUndistributedForeignEarnings" xlink:label="loc_us-gaap_DeferredTaxLiabilitiesUndistributedForeignEarnings_3BC08FEEFCD4B17CA34EF53749C9D188" xlink:type="locator" />
    <presentationArc order="23" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_477C0F73E88C5A745469F53749C81BD0" xlink:to="loc_us-gaap_DeferredTaxLiabilitiesUndistributedForeignEarnings_3BC08FEEFCD4B17CA34EF53749C9D188" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DeferredTaxLiabilitiesGoodwillAndIntangibleAssets" xlink:label="loc_us-gaap_DeferredTaxLiabilitiesGoodwillAndIntangibleAssets_4EEBB095137DD3027C17F53749C947D3" xlink:type="locator" />
    <presentationArc order="24" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_477C0F73E88C5A745469F53749C81BD0" xlink:to="loc_us-gaap_DeferredTaxLiabilitiesGoodwillAndIntangibleAssets_4EEBB095137DD3027C17F53749C947D3" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DeferredTaxLiabilitiesPrepaidExpenses" xlink:label="loc_us-gaap_DeferredTaxLiabilitiesPrepaidExpenses_921E46EBFF7D61CEDBB2F53749C9BE68" xlink:type="locator" />
    <presentationArc order="25" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_477C0F73E88C5A745469F53749C81BD0" xlink:to="loc_us-gaap_DeferredTaxLiabilitiesPrepaidExpenses_921E46EBFF7D61CEDBB2F53749C9BE68" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DeferredTaxLiabilitiesDeferredExpenseCapitalizedInventoryCosts" xlink:label="loc_us-gaap_DeferredTaxLiabilitiesDeferredExpenseCapitalizedInventoryCosts_E1CEA4B71152E6FF52BEF53749C96632" xlink:type="locator" />
    <presentationArc order="26" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_477C0F73E88C5A745469F53749C81BD0" xlink:to="loc_us-gaap_DeferredTaxLiabilitiesDeferredExpenseCapitalizedInventoryCosts_E1CEA4B71152E6FF52BEF53749C96632" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DeferredTaxLiabilitiesPropertyPlantAndEquipment" xlink:label="loc_us-gaap_DeferredTaxLiabilitiesPropertyPlantAndEquipment_0CD4D61767EA015BE201F53749C96D92" xlink:type="locator" />
    <presentationArc order="27" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_477C0F73E88C5A745469F53749C81BD0" xlink:to="loc_us-gaap_DeferredTaxLiabilitiesPropertyPlantAndEquipment_0CD4D61767EA015BE201F53749C96D92" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DeferredTaxLiabilitiesDerivatives" xlink:label="loc_us-gaap_DeferredTaxLiabilitiesDerivatives_40D856425384B25C8402F53749C9603B" xlink:type="locator" />
    <presentationArc order="28" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_477C0F73E88C5A745469F53749C81BD0" xlink:to="loc_us-gaap_DeferredTaxLiabilitiesDerivatives_40D856425384B25C8402F53749C9603B" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DeferredIncomeTaxLiabilities" xlink:label="loc_us-gaap_DeferredIncomeTaxLiabilities_8ED13AF4F2B46335FB2BF53749C952AD" xlink:type="locator" />
    <presentationArc order="29" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_477C0F73E88C5A745469F53749C81BD0" xlink:to="loc_us-gaap_DeferredIncomeTaxLiabilities_8ED13AF4F2B46335FB2BF53749C952AD" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DeferredTaxAssetsLiabilitiesNet" xlink:label="loc_us-gaap_DeferredTaxAssetsLiabilitiesNet_797302B0E9384F3FDB96F53749C98D0B" xlink:type="locator" />
    <presentationArc order="30" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_477C0F73E88C5A745469F53749C81BD0" xlink:to="loc_us-gaap_DeferredTaxAssetsLiabilitiesNet_797302B0E9384F3FDB96F53749C98D0B" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OperatingLossCarryforwards" xlink:label="loc_us-gaap_OperatingLossCarryforwards_71E0AA402BF52A4FDC7CF53749C907BF" xlink:type="locator" />
    <presentationArc order="31" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_477C0F73E88C5A745469F53749C81BD0" xlink:to="loc_us-gaap_OperatingLossCarryforwards_71E0AA402BF52A4FDC7CF53749C907BF" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OperatingLossCarryforwardsExpirationDate" xlink:label="loc_us-gaap_OperatingLossCarryforwardsExpirationDate_47DFA421CA371C77116DF53749C90398" xlink:type="locator" />
    <presentationArc order="32" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_477C0F73E88C5A745469F53749C81BD0" xlink:to="loc_us-gaap_OperatingLossCarryforwardsExpirationDate_47DFA421CA371C77116DF53749C90398" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_TaxCreditCarryforwardAmount" xlink:label="loc_us-gaap_TaxCreditCarryforwardAmount_8F5986A2AF3DD35C5C9BF53749CA22BC" xlink:type="locator" />
    <presentationArc order="33" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_477C0F73E88C5A745469F53749C81BD0" xlink:to="loc_us-gaap_TaxCreditCarryforwardAmount_8F5986A2AF3DD35C5C9BF53749CA22BC" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_TaxCreditCarryforwardExpirationDate" xlink:label="loc_us-gaap_TaxCreditCarryforwardExpirationDate_8DF9A62090CDB254EA1DF53749CAD4DE" xlink:type="locator" />
    <presentationArc order="34" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_477C0F73E88C5A745469F53749C81BD0" xlink:to="loc_us-gaap_TaxCreditCarryforwardExpirationDate_8DF9A62090CDB254EA1DF53749CAD4DE" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DeferredTaxAssetsOperatingLossCarryforwardsStateAndLocal" xlink:label="loc_us-gaap_DeferredTaxAssetsOperatingLossCarryforwardsStateAndLocal_20E63A8D9EC3279464F4F53749CA44BF" xlink:type="locator" />
    <presentationArc order="35" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_477C0F73E88C5A745469F53749C81BD0" xlink:to="loc_us-gaap_DeferredTaxAssetsOperatingLossCarryforwardsStateAndLocal_20E63A8D9EC3279464F4F53749CA44BF" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DeferredTaxAssetsTaxCreditCarryforwardsOther" xlink:label="loc_us-gaap_DeferredTaxAssetsTaxCreditCarryforwardsOther_AE97CB5C0704B372EFD1F53749CADCFC" xlink:type="locator" />
    <presentationArc order="36" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_477C0F73E88C5A745469F53749C81BD0" xlink:to="loc_us-gaap_DeferredTaxAssetsTaxCreditCarryforwardsOther_AE97CB5C0704B372EFD1F53749CADCFC" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DeferredTaxLiabilities" xlink:label="loc_us-gaap_DeferredTaxLiabilities_885BBBC2490280FCFF18F53749CA6CFE" xlink:type="locator" />
    <presentationArc order="37" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_477C0F73E88C5A745469F53749C81BD0" xlink:to="loc_us-gaap_DeferredTaxLiabilities_885BBBC2490280FCFF18F53749CA6CFE" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.lilly.com/role/IncomeTaxesIncomeTaxExpenseAndUnrecognizedTaxBenefitsDetails" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_IncomeTaxDisclosureAbstract" xlink:label="loc_us-gaap_IncomeTaxDisclosureAbstract_4AB2CDDAC63AE54DEA7EEF9B8850D11F" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_SignificantChangeInUnrecognizedTaxBenefitsIsReasonablyPossibleTable" xlink:label="loc_us-gaap_SignificantChangeInUnrecognizedTaxBenefitsIsReasonablyPossibleTable_D9F4BA7AA0D0CE9EC748EF9B8850679E" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_4AB2CDDAC63AE54DEA7EEF9B8850D11F" xlink:to="loc_us-gaap_SignificantChangeInUnrecognizedTaxBenefitsIsReasonablyPossibleTable_D9F4BA7AA0D0CE9EC748EF9B8850679E" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_TaxPeriodAxis" xlink:label="loc_us-gaap_TaxPeriodAxis_531BDED398C5718C0347EFA0577D263B" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SignificantChangeInUnrecognizedTaxBenefitsIsReasonablyPossibleTable_D9F4BA7AA0D0CE9EC748EF9B8850679E" xlink:to="loc_us-gaap_TaxPeriodAxis_531BDED398C5718C0347EFA0577D263B" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_TaxPeriodDomain" xlink:label="loc_us-gaap_TaxPeriodDomain_69950E7C54DA16A4C556EFA09E445C3F" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TaxPeriodAxis_531BDED398C5718C0347EFA0577D263B" xlink:to="loc_us-gaap_TaxPeriodDomain_69950E7C54DA16A4C556EFA09E445C3F" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_TaxYears20102012Member" xlink:label="loc_lly_TaxYears20102012Member_4FE478ACD4AE41EC8ECEEFA1542227DF" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TaxPeriodDomain_69950E7C54DA16A4C556EFA09E445C3F" xlink:to="loc_lly_TaxYears20102012Member_4FE478ACD4AE41EC8ECEEFA1542227DF" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_TaxCreditCarryforwardAxis" xlink:label="loc_us-gaap_TaxCreditCarryforwardAxis_DFDE256F15F82C2D9857EF9B88508F5A" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SignificantChangeInUnrecognizedTaxBenefitsIsReasonablyPossibleTable_D9F4BA7AA0D0CE9EC748EF9B8850679E" xlink:to="loc_us-gaap_TaxCreditCarryforwardAxis_DFDE256F15F82C2D9857EF9B88508F5A" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_TaxCreditCarryforwardNameDomain" xlink:label="loc_us-gaap_TaxCreditCarryforwardNameDomain_9AB1A114BC5A4E23B7FFEF9B885005A0" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TaxCreditCarryforwardAxis_DFDE256F15F82C2D9857EF9B88508F5A" xlink:to="loc_us-gaap_TaxCreditCarryforwardNameDomain_9AB1A114BC5A4E23B7FFEF9B885005A0" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_Expiration5to20YearsMinimumMember" xlink:label="loc_lly_Expiration5to20YearsMinimumMember_2499A9FB6075A760C53DEF9B8850F00B" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TaxCreditCarryforwardNameDomain_9AB1A114BC5A4E23B7FFEF9B885005A0" xlink:to="loc_lly_Expiration5to20YearsMinimumMember_2499A9FB6075A760C53DEF9B8850F00B" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_Expiration5to20YearsMember" xlink:label="loc_lly_Expiration5to20YearsMember_CA030D6BFFF1C8C9F0A3EF9B8850C88C" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TaxCreditCarryforwardNameDomain_9AB1A114BC5A4E23B7FFEF9B885005A0" xlink:to="loc_lly_Expiration5to20YearsMember_CA030D6BFFF1C8C9F0A3EF9B8850C88C" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_Expiration5to20YearsMaximumMember" xlink:label="loc_lly_Expiration5to20YearsMaximumMember_56632391C44559EAC18CEF9B8850412F" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TaxCreditCarryforwardNameDomain_9AB1A114BC5A4E23B7FFEF9B885005A0" xlink:to="loc_lly_Expiration5to20YearsMaximumMember_56632391C44559EAC18CEF9B8850412F" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ReasonablyPossibleSignificantChangeInUnrecognizedTaxBenefitsByItemAxis" xlink:label="loc_us-gaap_ReasonablyPossibleSignificantChangeInUnrecognizedTaxBenefitsByItemAxis_FA170D8A43FB49C6CEB8EF9B8850090F" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SignificantChangeInUnrecognizedTaxBenefitsIsReasonablyPossibleTable_D9F4BA7AA0D0CE9EC748EF9B8850679E" xlink:to="loc_us-gaap_ReasonablyPossibleSignificantChangeInUnrecognizedTaxBenefitsByItemAxis_FA170D8A43FB49C6CEB8EF9B8850090F" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_SignificantChangeInUnrecognizedTaxBenefitsIsReasonablyPossibleNatureOfUncertaintyDomain" xlink:label="loc_us-gaap_SignificantChangeInUnrecognizedTaxBenefitsIsReasonablyPossibleNatureOfUncertaintyDomain_E8E41FE416B32927DAA1EF9B88502C5C" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ReasonablyPossibleSignificantChangeInUnrecognizedTaxBenefitsByItemAxis_FA170D8A43FB49C6CEB8EF9B8850090F" xlink:to="loc_us-gaap_SignificantChangeInUnrecognizedTaxBenefitsIsReasonablyPossibleNatureOfUncertaintyDomain_E8E41FE416B32927DAA1EF9B88502C5C" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_RangeAxis" xlink:label="loc_us-gaap_RangeAxis_EE5C3E83089DE58FD889EF9B88506F31" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SignificantChangeInUnrecognizedTaxBenefitsIsReasonablyPossibleTable_D9F4BA7AA0D0CE9EC748EF9B8850679E" xlink:to="loc_us-gaap_RangeAxis_EE5C3E83089DE58FD889EF9B88506F31" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_RangeMember" xlink:label="loc_us-gaap_RangeMember_72D75DF4044602A3F4F1EF9B88509D77" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RangeAxis_EE5C3E83089DE58FD889EF9B88506F31" xlink:to="loc_us-gaap_RangeMember_72D75DF4044602A3F4F1EF9B88509D77" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_MinimumMember" xlink:label="loc_us-gaap_MinimumMember_D39C6F8F2A1DAD22053CEF9B88506923" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RangeMember_72D75DF4044602A3F4F1EF9B88509D77" xlink:to="loc_us-gaap_MinimumMember_D39C6F8F2A1DAD22053CEF9B88506923" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_MaximumMember" xlink:label="loc_us-gaap_MaximumMember_48AEC4D7CCD0A5FC0B54EF9B8850C5D7" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RangeMember_72D75DF4044602A3F4F1EF9B88509D77" xlink:to="loc_us-gaap_MaximumMember_48AEC4D7CCD0A5FC0B54EF9B8850C5D7" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_SignificantChangeInUnrecognizedTaxBenefitsIsReasonablyPossibleLineItems" xlink:label="loc_us-gaap_SignificantChangeInUnrecognizedTaxBenefitsIsReasonablyPossibleLineItems_3927B2F3C9B720713344EF9B88504D98" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SignificantChangeInUnrecognizedTaxBenefitsIsReasonablyPossibleTable_D9F4BA7AA0D0CE9EC748EF9B8850679E" xlink:to="loc_us-gaap_SignificantChangeInUnrecognizedTaxBenefitsIsReasonablyPossibleLineItems_3927B2F3C9B720713344EF9B88504D98" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OperatingLossCarryforwardsExpirationDate" xlink:label="loc_us-gaap_OperatingLossCarryforwardsExpirationDate_3C72A8FE40858010BC28EF9B8850C717" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SignificantChangeInUnrecognizedTaxBenefitsIsReasonablyPossibleLineItems_3927B2F3C9B720713344EF9B88504D98" xlink:to="loc_us-gaap_OperatingLossCarryforwardsExpirationDate_3C72A8FE40858010BC28EF9B8850C717" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OperatingLossCarryforwards" xlink:label="loc_us-gaap_OperatingLossCarryforwards_130F416618AF5040E4A8EF9B885074D3" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SignificantChangeInUnrecognizedTaxBenefitsIsReasonablyPossibleLineItems_3927B2F3C9B720713344EF9B88504D98" xlink:to="loc_us-gaap_OperatingLossCarryforwards_130F416618AF5040E4A8EF9B885074D3" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_IncomeTaxExaminationYearUnderExamination" xlink:label="loc_us-gaap_IncomeTaxExaminationYearUnderExamination_94A5F9F6BA8ED09A7964EF9B885088D4" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SignificantChangeInUnrecognizedTaxBenefitsIsReasonablyPossibleLineItems_3927B2F3C9B720713344EF9B88504D98" xlink:to="loc_us-gaap_IncomeTaxExaminationYearUnderExamination_94A5F9F6BA8ED09A7964EF9B885088D4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DecreaseInUnrecognizedTaxBenefitsIsReasonablyPossible" xlink:label="loc_us-gaap_DecreaseInUnrecognizedTaxBenefitsIsReasonablyPossible_291D68CDBD987E4B031AEF9B8850FA09" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SignificantChangeInUnrecognizedTaxBenefitsIsReasonablyPossibleLineItems_3927B2F3C9B720713344EF9B88504D98" xlink:to="loc_us-gaap_DecreaseInUnrecognizedTaxBenefitsIsReasonablyPossible_291D68CDBD987E4B031AEF9B8850FA09" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_IncomeTaxExaminationEstimateofCashPaymentforTaxesfromSettlementwithTaxingAuthority" xlink:label="loc_lly_IncomeTaxExaminationEstimateofCashPaymentforTaxesfromSettlementwithTaxingAuthority_469F82D12BDBB2292BB6EF9B8850839B" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SignificantChangeInUnrecognizedTaxBenefitsIsReasonablyPossibleLineItems_3927B2F3C9B720713344EF9B88504D98" xlink:to="loc_lly_IncomeTaxExaminationEstimateofCashPaymentforTaxesfromSettlementwithTaxingAuthority_469F82D12BDBB2292BB6EF9B8850839B" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_DomesticandPuertoRicanContributiontoIncomebeforeIncomeTaxes" xlink:label="loc_lly_DomesticandPuertoRicanContributiontoIncomebeforeIncomeTaxes_8791BCD2EADC9A585A54EF9B885035A2" xlink:type="locator" />
    <presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SignificantChangeInUnrecognizedTaxBenefitsIsReasonablyPossibleLineItems_3927B2F3C9B720713344EF9B88504D98" xlink:to="loc_lly_DomesticandPuertoRicanContributiontoIncomebeforeIncomeTaxes_8791BCD2EADC9A585A54EF9B885035A2" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_IncomeTaxHolidayTerminationDate" xlink:label="loc_us-gaap_IncomeTaxHolidayTerminationDate_FC3B66F0B28D0C6F161FEF9B8850FF7A" xlink:type="locator" />
    <presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SignificantChangeInUnrecognizedTaxBenefitsIsReasonablyPossibleLineItems_3927B2F3C9B720713344EF9B88504D98" xlink:to="loc_us-gaap_IncomeTaxHolidayTerminationDate_FC3B66F0B28D0C6F161FEF9B8850FF7A" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_IncomeTaxHolidayCommencementDate" xlink:label="loc_lly_IncomeTaxHolidayCommencementDate_35F94A213DE28F498A22EF9B885079B8" xlink:type="locator" />
    <presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SignificantChangeInUnrecognizedTaxBenefitsIsReasonablyPossibleLineItems_3927B2F3C9B720713344EF9B88504D98" xlink:to="loc_lly_IncomeTaxHolidayCommencementDate_35F94A213DE28F498A22EF9B885079B8" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_IncomeTaxHolidayDescription" xlink:label="loc_us-gaap_IncomeTaxHolidayDescription_0FC1B1E026AC23333140EF9B8850793C" xlink:type="locator" />
    <presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SignificantChangeInUnrecognizedTaxBenefitsIsReasonablyPossibleLineItems_3927B2F3C9B720713344EF9B88504D98" xlink:to="loc_us-gaap_IncomeTaxHolidayDescription_0FC1B1E026AC23333140EF9B8850793C" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_IncomeTaxesPaid" xlink:label="loc_us-gaap_IncomeTaxesPaid_CF4387E80749E39E9381EF9B8850C2D8" xlink:type="locator" />
    <presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SignificantChangeInUnrecognizedTaxBenefitsIsReasonablyPossibleLineItems_3927B2F3C9B720713344EF9B88504D98" xlink:to="loc_us-gaap_IncomeTaxesPaid_CF4387E80749E39E9381EF9B8850C2D8" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_IncomeTaxReconciliationIncomeTaxExpenseBenefitAtFederalStatutoryIncomeTaxRate" xlink:label="loc_us-gaap_IncomeTaxReconciliationIncomeTaxExpenseBenefitAtFederalStatutoryIncomeTaxRate_97A55BC04C7F8CD30FDEEF9B88508186" xlink:type="locator" />
    <presentationArc order="11" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SignificantChangeInUnrecognizedTaxBenefitsIsReasonablyPossibleLineItems_3927B2F3C9B720713344EF9B88504D98" xlink:to="loc_us-gaap_IncomeTaxReconciliationIncomeTaxExpenseBenefitAtFederalStatutoryIncomeTaxRate_97A55BC04C7F8CD30FDEEF9B88508186" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_IncomeTaxReconciliationTaxCreditsForeign" xlink:label="loc_us-gaap_IncomeTaxReconciliationTaxCreditsForeign_57BC395B2715F97A547AEF9B885006ED" xlink:type="locator" />
    <presentationArc order="12" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SignificantChangeInUnrecognizedTaxBenefitsIsReasonablyPossibleLineItems_3927B2F3C9B720713344EF9B88504D98" xlink:to="loc_us-gaap_IncomeTaxReconciliationTaxCreditsForeign_57BC395B2715F97A547AEF9B885006ED" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_IncomeTaxReconciliationTaxCredits" xlink:label="loc_us-gaap_IncomeTaxReconciliationTaxCredits_8A47DC28B238D761D8E9EF9B8850AAC5" xlink:type="locator" />
    <presentationArc order="13" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SignificantChangeInUnrecognizedTaxBenefitsIsReasonablyPossibleLineItems_3927B2F3C9B720713344EF9B88504D98" xlink:to="loc_us-gaap_IncomeTaxReconciliationTaxCredits_8A47DC28B238D761D8E9EF9B8850AAC5" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_IncomeTaxReconciliationOtherAdjustments" xlink:label="loc_us-gaap_IncomeTaxReconciliationOtherAdjustments_C524CEC038CA4A2CDBFBEF9B8850AF2D" xlink:type="locator" />
    <presentationArc order="14" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SignificantChangeInUnrecognizedTaxBenefitsIsReasonablyPossibleLineItems_3927B2F3C9B720713344EF9B88504D98" xlink:to="loc_us-gaap_IncomeTaxReconciliationOtherAdjustments_C524CEC038CA4A2CDBFBEF9B8850AF2D" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_IncomeTaxExpenseBenefit" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_F5936338EA3F4ED3FEB0EF9B88504301" xlink:type="locator" />
    <presentationArc order="15" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SignificantChangeInUnrecognizedTaxBenefitsIsReasonablyPossibleLineItems_3927B2F3C9B720713344EF9B88504D98" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_F5936338EA3F4ED3FEB0EF9B88504301" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_UnrecognizedTaxBenefits" xlink:label="loc_us-gaap_UnrecognizedTaxBenefits_EE7207655D570386EFD3EF9B885A99DD" xlink:type="locator" />
    <presentationArc order="16" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SignificantChangeInUnrecognizedTaxBenefitsIsReasonablyPossibleLineItems_3927B2F3C9B720713344EF9B88504D98" xlink:to="loc_us-gaap_UnrecognizedTaxBenefits_EE7207655D570386EFD3EF9B885A99DD" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_UnrecognizedTaxBenefitsIncreasesResultingFromCurrentPeriodTaxPositions" xlink:label="loc_us-gaap_UnrecognizedTaxBenefitsIncreasesResultingFromCurrentPeriodTaxPositions_ECE85C24F043A277C51EEF9B885A99AA" xlink:type="locator" />
    <presentationArc order="17" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SignificantChangeInUnrecognizedTaxBenefitsIsReasonablyPossibleLineItems_3927B2F3C9B720713344EF9B88504D98" xlink:to="loc_us-gaap_UnrecognizedTaxBenefitsIncreasesResultingFromCurrentPeriodTaxPositions_ECE85C24F043A277C51EEF9B885A99AA" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_UnrecognizedTaxBenefitsIncreasesResultingFromPriorPeriodTaxPositions" xlink:label="loc_us-gaap_UnrecognizedTaxBenefitsIncreasesResultingFromPriorPeriodTaxPositions_0FCAF4F2B11974EE60ACEF9B885ACB41" xlink:type="locator" />
    <presentationArc order="18" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SignificantChangeInUnrecognizedTaxBenefitsIsReasonablyPossibleLineItems_3927B2F3C9B720713344EF9B88504D98" xlink:to="loc_us-gaap_UnrecognizedTaxBenefitsIncreasesResultingFromPriorPeriodTaxPositions_0FCAF4F2B11974EE60ACEF9B885ACB41" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_UnrecognizedTaxBenefitsDecreasesResultingFromPriorPeriodTaxPositions" xlink:label="loc_us-gaap_UnrecognizedTaxBenefitsDecreasesResultingFromPriorPeriodTaxPositions_D347492A41FB9F53E759EF9B885ACC56" xlink:type="locator" />
    <presentationArc order="19" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SignificantChangeInUnrecognizedTaxBenefitsIsReasonablyPossibleLineItems_3927B2F3C9B720713344EF9B88504D98" xlink:to="loc_us-gaap_UnrecognizedTaxBenefitsDecreasesResultingFromPriorPeriodTaxPositions_D347492A41FB9F53E759EF9B885ACC56" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_UnrecognizedTaxBenefitsReductionsResultingFromLapseOfApplicableStatuteOfLimitations" xlink:label="loc_us-gaap_UnrecognizedTaxBenefitsReductionsResultingFromLapseOfApplicableStatuteOfLimitations_80B73DD78525F8FA6DE7EF9B885A96AE" xlink:type="locator" />
    <presentationArc order="20" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SignificantChangeInUnrecognizedTaxBenefitsIsReasonablyPossibleLineItems_3927B2F3C9B720713344EF9B88504D98" xlink:to="loc_us-gaap_UnrecognizedTaxBenefitsReductionsResultingFromLapseOfApplicableStatuteOfLimitations_80B73DD78525F8FA6DE7EF9B885A96AE" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_UnrecognizedTaxBenefitsDecreasesResultingFromSettlementsWithTaxingAuthorities" xlink:label="loc_us-gaap_UnrecognizedTaxBenefitsDecreasesResultingFromSettlementsWithTaxingAuthorities_E33ADFE9F037CFF84972EF9B885A8FBD" xlink:type="locator" />
    <presentationArc order="21" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SignificantChangeInUnrecognizedTaxBenefitsIsReasonablyPossibleLineItems_3927B2F3C9B720713344EF9B88504D98" xlink:to="loc_us-gaap_UnrecognizedTaxBenefitsDecreasesResultingFromSettlementsWithTaxingAuthorities_E33ADFE9F037CFF84972EF9B885A8FBD" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_UnrecognizedTaxBenefitsDecreasesResultingFromForeignCurrencyTranslation" xlink:label="loc_us-gaap_UnrecognizedTaxBenefitsDecreasesResultingFromForeignCurrencyTranslation_BF8BF9289F088A74D3E6EF9B885AFA12" xlink:type="locator" />
    <presentationArc order="22" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SignificantChangeInUnrecognizedTaxBenefitsIsReasonablyPossibleLineItems_3927B2F3C9B720713344EF9B88504D98" xlink:to="loc_us-gaap_UnrecognizedTaxBenefitsDecreasesResultingFromForeignCurrencyTranslation_BF8BF9289F088A74D3E6EF9B885AFA12" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_UnrecognizedTaxBenefits" xlink:label="loc_us-gaap_UnrecognizedTaxBenefits_1D3CF7C212F681693100EF9B885A8ECA" xlink:type="locator" />
    <presentationArc order="23" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SignificantChangeInUnrecognizedTaxBenefitsIsReasonablyPossibleLineItems_3927B2F3C9B720713344EF9B88504D98" xlink:to="loc_us-gaap_UnrecognizedTaxBenefits_1D3CF7C212F681693100EF9B885A8ECA" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_UnrecognizedTaxBenefitsThatWouldImpactEffectiveTaxRate" xlink:label="loc_us-gaap_UnrecognizedTaxBenefitsThatWouldImpactEffectiveTaxRate_A53301BDEF4B03164184EF9B885A47F0" xlink:type="locator" />
    <presentationArc order="24" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SignificantChangeInUnrecognizedTaxBenefitsIsReasonablyPossibleLineItems_3927B2F3C9B720713344EF9B88504D98" xlink:to="loc_us-gaap_UnrecognizedTaxBenefitsThatWouldImpactEffectiveTaxRate_A53301BDEF4B03164184EF9B885A47F0" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_IncomeTaxExaminationLiabilityRefundAdjustmentFromSettlementWithTaxingAuthority" xlink:label="loc_us-gaap_IncomeTaxExaminationLiabilityRefundAdjustmentFromSettlementWithTaxingAuthority_C2661315CF0770C5CFF3EF9B885A8182" xlink:type="locator" />
    <presentationArc order="25" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SignificantChangeInUnrecognizedTaxBenefitsIsReasonablyPossibleLineItems_3927B2F3C9B720713344EF9B88504D98" xlink:to="loc_us-gaap_IncomeTaxExaminationLiabilityRefundAdjustmentFromSettlementWithTaxingAuthority_C2661315CF0770C5CFF3EF9B885A8182" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_UnrecognizedTaxBenefitsIncomeTaxPenaltiesAndInterestExpense" xlink:label="loc_us-gaap_UnrecognizedTaxBenefitsIncomeTaxPenaltiesAndInterestExpense_543607557DAED6040D39EF9B885A6BA9" xlink:type="locator" />
    <presentationArc order="26" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SignificantChangeInUnrecognizedTaxBenefitsIsReasonablyPossibleLineItems_3927B2F3C9B720713344EF9B88504D98" xlink:to="loc_us-gaap_UnrecognizedTaxBenefitsIncomeTaxPenaltiesAndInterestExpense_543607557DAED6040D39EF9B885A6BA9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_UnrecognizedTaxBenefitsIncomeTaxPenaltiesAndInterestAccrued" xlink:label="loc_us-gaap_UnrecognizedTaxBenefitsIncomeTaxPenaltiesAndInterestAccrued_10758310555C5802B56BEF9B885A3000" xlink:type="locator" />
    <presentationArc order="27" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SignificantChangeInUnrecognizedTaxBenefitsIsReasonablyPossibleLineItems_3927B2F3C9B720713344EF9B88504D98" xlink:to="loc_us-gaap_UnrecognizedTaxBenefitsIncomeTaxPenaltiesAndInterestAccrued_10758310555C5802B56BEF9B885A3000" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.lilly.com/role/IncomeTaxesIncomeTaxesPolicies" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_IncomeTaxDisclosureAbstract" xlink:label="loc_us-gaap_IncomeTaxDisclosureAbstract_8E3D66A5EF9CDC5C7A6EFC036F7942B0" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_IncomeTaxPolicyTextBlock" xlink:label="loc_us-gaap_IncomeTaxPolicyTextBlock_EB07C166E674E931DEBFFC036F79DAD4" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_8E3D66A5EF9CDC5C7A6EFC036F7942B0" xlink:to="loc_us-gaap_IncomeTaxPolicyTextBlock_EB07C166E674E931DEBFFC036F79DAD4" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.lilly.com/role/IncomeTaxesTables" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_IncomeTaxDisclosureAbstract" xlink:label="loc_us-gaap_IncomeTaxDisclosureAbstract_FADEBFB3B6E689D3CABCF4D92409EF4C" xlink:type="locator" />
    <loc xlink:href="lly-20151231.xsd#lly_ScheduleofAdditionalIncomeTaxDisclosuresTableTextBlock" xlink:label="loc_lly_ScheduleofAdditionalIncomeTaxDisclosuresTableTextBlock_7DE01E3D0EFB372B3576F4D9BFB9662A" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_FADEBFB3B6E689D3CABCF4D92409EF4C" xlink:to="loc_lly_ScheduleofAdditionalIncomeTaxDisclosuresTableTextBlock_7DE01E3D0EFB372B3576F4D9BFB9662A" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScheduleOfComponentsOfIncomeTaxExpenseBenefitTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfComponentsOfIncomeTaxExpenseBenefitTableTextBlock_FFA3140A6E4E72BC9387F4D924093A4A" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_FADEBFB3B6E689D3CABCF4D92409EF4C" xlink:to="loc_us-gaap_ScheduleOfComponentsOfIncomeTaxExpenseBenefitTableTextBlock_FFA3140A6E4E72BC9387F4D924093A4A" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScheduleOfDeferredTaxAssetsAndLiabilitiesTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfDeferredTaxAssetsAndLiabilitiesTableTextBlock_05554C029E8C47142CB0F4D92409D5C2" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_FADEBFB3B6E689D3CABCF4D92409EF4C" xlink:to="loc_us-gaap_ScheduleOfDeferredTaxAssetsAndLiabilitiesTableTextBlock_05554C029E8C47142CB0F4D92409D5C2" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScheduleOfEffectiveIncomeTaxRateReconciliationTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfEffectiveIncomeTaxRateReconciliationTableTextBlock_54C26BCA2B7EFA30D566F4D924096778" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_FADEBFB3B6E689D3CABCF4D92409EF4C" xlink:to="loc_us-gaap_ScheduleOfEffectiveIncomeTaxRateReconciliationTableTextBlock_54C26BCA2B7EFA30D566F4D924096778" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_SummaryOfIncomeTaxContingenciesTextBlock" xlink:label="loc_us-gaap_SummaryOfIncomeTaxContingenciesTextBlock_8225F33C8E579E46CC6AF4D92409E9E9" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_FADEBFB3B6E689D3CABCF4D92409EF4C" xlink:to="loc_us-gaap_SummaryOfIncomeTaxContingenciesTextBlock_8225F33C8E579E46CC6AF4D92409E9E9" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.lilly.com/role/InventoriesDetails" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_InventoryDisclosureAbstract" xlink:label="loc_us-gaap_InventoryDisclosureAbstract_4A44B02491473599D309FC037113967D" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_InventoryCurrentTable" xlink:label="loc_us-gaap_InventoryCurrentTable_44D706DB3AACDAB4A382FC037113C419" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InventoryDisclosureAbstract_4A44B02491473599D309FC037113967D" xlink:to="loc_us-gaap_InventoryCurrentTable_44D706DB3AACDAB4A382FC037113C419" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PublicUtilitiesInventoryAxis" xlink:label="loc_us-gaap_PublicUtilitiesInventoryAxis_0839EAA4F242E8D3916FFC0371135F43" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InventoryCurrentTable_44D706DB3AACDAB4A382FC037113C419" xlink:to="loc_us-gaap_PublicUtilitiesInventoryAxis_0839EAA4F242E8D3916FFC0371135F43" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PublicUtilitiesInventoryTypeDomain" xlink:label="loc_us-gaap_PublicUtilitiesInventoryTypeDomain_EDB56C527ADED86397E6FC037113106A" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PublicUtilitiesInventoryAxis_0839EAA4F242E8D3916FFC0371135F43" xlink:to="loc_us-gaap_PublicUtilitiesInventoryTypeDomain_EDB56C527ADED86397E6FC037113106A" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_InventoryLineItems" xlink:label="loc_us-gaap_InventoryLineItems_32EBC2C020398BAE855DFC037113BD26" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InventoryCurrentTable_44D706DB3AACDAB4A382FC037113C419" xlink:to="loc_us-gaap_InventoryLineItems_32EBC2C020398BAE855DFC037113BD26" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_LIFOInventoryAmount" xlink:label="loc_us-gaap_LIFOInventoryAmount_3024DB01C95688595B49FC0371139C66" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InventoryLineItems_32EBC2C020398BAE855DFC037113BD26" xlink:to="loc_us-gaap_LIFOInventoryAmount_3024DB01C95688595B49FC0371139C66" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_InventoryFinishedGoods" xlink:label="loc_us-gaap_InventoryFinishedGoods_DA3A8BAAE8B0CF979048FC037113D487" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InventoryLineItems_32EBC2C020398BAE855DFC037113BD26" xlink:to="loc_us-gaap_InventoryFinishedGoods_DA3A8BAAE8B0CF979048FC037113D487" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_InventoryWorkInProcess" xlink:label="loc_us-gaap_InventoryWorkInProcess_48B1408DA78804AC6CF2FC037113A13C" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InventoryLineItems_32EBC2C020398BAE855DFC037113BD26" xlink:to="loc_us-gaap_InventoryWorkInProcess_48B1408DA78804AC6CF2FC037113A13C" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_InventoryRawMaterials" xlink:label="loc_us-gaap_InventoryRawMaterials_6DE74EC4D72A9202C5CFFC0371133266" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InventoryLineItems_32EBC2C020398BAE855DFC037113BD26" xlink:to="loc_us-gaap_InventoryRawMaterials_6DE74EC4D72A9202C5CFFC0371133266" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_InventoryGross" xlink:label="loc_us-gaap_InventoryGross_7C910BEF8885CE0188B4FC03711325DF" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InventoryLineItems_32EBC2C020398BAE855DFC037113BD26" xlink:to="loc_us-gaap_InventoryGross_7C910BEF8885CE0188B4FC03711325DF" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_InventoryLIFOReserve" xlink:label="loc_us-gaap_InventoryLIFOReserve_621C425374C74FC41E4DFC0371130A7D" xlink:type="locator" />
    <presentationArc order="6" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InventoryLineItems_32EBC2C020398BAE855DFC037113BD26" xlink:to="loc_us-gaap_InventoryLIFOReserve_621C425374C74FC41E4DFC0371130A7D" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_InventoryNet" xlink:label="loc_us-gaap_InventoryNet_E1345D07E7D04E18DB01FC0371138A88" xlink:type="locator" />
    <presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InventoryLineItems_32EBC2C020398BAE855DFC037113BD26" xlink:to="loc_us-gaap_InventoryNet_E1345D07E7D04E18DB01FC0371138A88" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.lilly.com/role/InventoriesInventoriesPoliciesPolicies" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_InventoryDisclosureAbstract" xlink:label="loc_us-gaap_InventoryDisclosureAbstract_22A90B78F65E2584586AFC036E574D73" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_InventoryPolicyTextBlock" xlink:label="loc_us-gaap_InventoryPolicyTextBlock_43E7D4E69FBE724A7718FC036E573601" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InventoryDisclosureAbstract_22A90B78F65E2584586AFC036E574D73" xlink:to="loc_us-gaap_InventoryPolicyTextBlock_43E7D4E69FBE724A7718FC036E573601" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.lilly.com/role/InventoriesNotes" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_InventoryDisclosureAbstract" xlink:label="loc_us-gaap_InventoryDisclosureAbstract_45069AAC027DC2B1BFC5FC036ED9F294" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_InventoryDisclosureTextBlock" xlink:label="loc_us-gaap_InventoryDisclosureTextBlock_6D8E027360705A50173DFC036ED9BF60" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InventoryDisclosureAbstract_45069AAC027DC2B1BFC5FC036ED9F294" xlink:to="loc_us-gaap_InventoryDisclosureTextBlock_6D8E027360705A50173DFC036ED9BF60" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.lilly.com/role/InventoriesTables" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_InventoryDisclosureAbstract" xlink:label="loc_us-gaap_InventoryDisclosureAbstract_CA1C98F74A1892D87C85FC0370CD3C48" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_InventoryCurrentTable" xlink:label="loc_us-gaap_InventoryCurrentTable_B4E51274598E11F219C8FC0370CD1DC7" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InventoryDisclosureAbstract_CA1C98F74A1892D87C85FC0370CD3C48" xlink:to="loc_us-gaap_InventoryCurrentTable_B4E51274598E11F219C8FC0370CD1DC7" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PublicUtilitiesInventoryAxis" xlink:label="loc_us-gaap_PublicUtilitiesInventoryAxis_316087811652104D181EFC0370CDF70F" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InventoryCurrentTable_B4E51274598E11F219C8FC0370CD1DC7" xlink:to="loc_us-gaap_PublicUtilitiesInventoryAxis_316087811652104D181EFC0370CDF70F" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PublicUtilitiesInventoryTypeDomain" xlink:label="loc_us-gaap_PublicUtilitiesInventoryTypeDomain_4455D89978033A905F1EFC0370D7FF36" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PublicUtilitiesInventoryAxis_316087811652104D181EFC0370CDF70F" xlink:to="loc_us-gaap_PublicUtilitiesInventoryTypeDomain_4455D89978033A905F1EFC0370D7FF36" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_InventoryLineItems" xlink:label="loc_us-gaap_InventoryLineItems_E9A206AA80420C8A291DFC0370D788F9" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InventoryCurrentTable_B4E51274598E11F219C8FC0370CD1DC7" xlink:to="loc_us-gaap_InventoryLineItems_E9A206AA80420C8A291DFC0370D788F9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScheduleOfInventoryCurrentTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfInventoryCurrentTableTextBlock_1D129FDE2DB971401B7DFC0370D74C8C" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InventoryLineItems_E9A206AA80420C8A291DFC0370D788F9" xlink:to="loc_us-gaap_ScheduleOfInventoryCurrentTableTextBlock_1D129FDE2DB971401B7DFC0370D74C8C" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.lilly.com/role/OtherComprehensiveIncomeLoss" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossTaxAbstract" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossTaxAbstract_94CF40E3F1B54E8A27E1FC0370F544DD" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ComprehensiveIncomeNoteTextBlock" xlink:label="loc_us-gaap_ComprehensiveIncomeNoteTextBlock_C69086D52F6D2030A665FC0370F5F272" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossTaxAbstract_94CF40E3F1B54E8A27E1FC0370F544DD" xlink:to="loc_us-gaap_ComprehensiveIncomeNoteTextBlock_C69086D52F6D2030A665FC0370F5F272" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.lilly.com/role/OtherComprehensiveIncomeLossDetails" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossTaxAbstract" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossTaxAbstract_5F59FB8882E775FB55E2EA6D6780C142" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StatementTable" xlink:label="loc_us-gaap_StatementTable_2745D3B1637811BC4298EA6D67809309" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossTaxAbstract_5F59FB8882E775FB55E2EA6D6780C142" xlink:to="loc_us-gaap_StatementTable_2745D3B1637811BC4298EA6D67809309" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StatementEquityComponentsAxis" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_DD8B7316BBADA8C40D17EA6D6780F9B9" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_2745D3B1637811BC4298EA6D67809309" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_DD8B7316BBADA8C40D17EA6D6780F9B9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_EquityComponentDomain" xlink:label="loc_us-gaap_EquityComponentDomain_DCBA9435DCC1054ABEA0EA6D67803CBB" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_DD8B7316BBADA8C40D17EA6D6780F9B9" xlink:to="loc_us-gaap_EquityComponentDomain_DCBA9435DCC1054ABEA0EA6D67803CBB" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeMember" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_D80C7F36345D22CC0005EA6D6780F80D" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_DCBA9435DCC1054ABEA0EA6D67803CBB" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_D80C7F36345D22CC0005EA6D6780F80D" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AccumulatedTranslationAdjustmentMember" xlink:label="loc_us-gaap_AccumulatedTranslationAdjustmentMember_C94EC05E7BD192E6BB67EA6D678060C7" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_D80C7F36345D22CC0005EA6D6780F80D" xlink:to="loc_us-gaap_AccumulatedTranslationAdjustmentMember_C94EC05E7BD192E6BB67EA6D678060C7" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AccumulatedNetUnrealizedInvestmentGainLossMember" xlink:label="loc_us-gaap_AccumulatedNetUnrealizedInvestmentGainLossMember_716A8E439DD6473A2513EA6D678026B2" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_D80C7F36345D22CC0005EA6D6780F80D" xlink:to="loc_us-gaap_AccumulatedNetUnrealizedInvestmentGainLossMember_716A8E439DD6473A2513EA6D678026B2" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AccumulatedDefinedBenefitPlansAdjustmentMember" xlink:label="loc_us-gaap_AccumulatedDefinedBenefitPlansAdjustmentMember_609259C7C13E29B634ACEA6D678058D5" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_D80C7F36345D22CC0005EA6D6780F80D" xlink:to="loc_us-gaap_AccumulatedDefinedBenefitPlansAdjustmentMember_609259C7C13E29B634ACEA6D678058D5" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AccumulatedNetGainLossFromDesignatedOrQualifyingCashFlowHedgesMember" xlink:label="loc_us-gaap_AccumulatedNetGainLossFromDesignatedOrQualifyingCashFlowHedgesMember_86E82EAF9574555B22E6EA6D67804249" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_D80C7F36345D22CC0005EA6D6780F80D" xlink:to="loc_us-gaap_AccumulatedNetGainLossFromDesignatedOrQualifyingCashFlowHedgesMember_86E82EAF9574555B22E6EA6D67804249" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_C435CDF1988BB858A0A4EA6D6780CEEC" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_2745D3B1637811BC4298EA6D67809309" xlink:to="loc_us-gaap_StatementLineItems_C435CDF1988BB858A0A4EA6D6780CEEC" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossAmortizationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansForNetPriorServiceCostCreditBeforeTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossAmortizationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansForNetPriorServiceCostCreditBeforeTax_C951BA59DE5D3AB5B33FEA6D6780DF74" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_C435CDF1988BB858A0A4EA6D6780CEEC" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossAmortizationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansForNetPriorServiceCostCreditBeforeTax_C951BA59DE5D3AB5B33FEA6D6780DF74" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTranslationAdjustmentTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTranslationAdjustmentTax_0F405226C1F69E3C60F9EA6D67810C7D" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_C435CDF1988BB858A0A4EA6D6780CEEC" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTranslationAdjustmentTax_0F405226C1F69E3C60F9EA6D67810C7D" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodTax_8591E43AE411E3FFB696EA6D6781E735" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_C435CDF1988BB858A0A4EA6D6780CEEC" xlink:to="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodTax_8591E43AE411E3FFB696EA6D6781E735" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_3FFBFBC4672E25774A2DEA6D67816C6B" xlink:type="locator" />
    <presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_C435CDF1988BB858A0A4EA6D6780CEEC" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_3FFBFBC4672E25774A2DEA6D67816C6B" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossBeforeReclassificationsNetOfTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossBeforeReclassificationsNetOfTax_E6847EA4D316F0153D1AEA6D6781420C" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_C435CDF1988BB858A0A4EA6D6780CEEC" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossBeforeReclassificationsNetOfTax_E6847EA4D316F0153D1AEA6D6781420C" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_123F2FA1E701CDC2EF67EA6D678144E0" xlink:type="locator" />
    <presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_C435CDF1988BB858A0A4EA6D6780CEEC" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_123F2FA1E701CDC2EF67EA6D678144E0" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansBeforeTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansBeforeTax_49E9ECFF344527C082A7EA6D67815A7E" xlink:type="locator" />
    <presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_C435CDF1988BB858A0A4EA6D6780CEEC" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansBeforeTax_49E9ECFF344527C082A7EA6D67815A7E" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DefinedBenefitPlanAccumulatedOtherComprehensiveIncomeNetGainsLossesBeforeTax" xlink:label="loc_us-gaap_DefinedBenefitPlanAccumulatedOtherComprehensiveIncomeNetGainsLossesBeforeTax_A4F074E6AB3DEB34759FEA6D67815C38" xlink:type="locator" />
    <presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_C435CDF1988BB858A0A4EA6D6780CEEC" xlink:to="loc_us-gaap_DefinedBenefitPlanAccumulatedOtherComprehensiveIncomeNetGainsLossesBeforeTax_A4F074E6AB3DEB34759FEA6D67815C38" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansForNetGainLossBeforeTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansForNetGainLossBeforeTax_E85D4E9439F244769091EA6D67819972" xlink:type="locator" />
    <presentationArc order="9" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_C435CDF1988BB858A0A4EA6D6780CEEC" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansForNetGainLossBeforeTax_E85D4E9439F244769091EA6D67819972" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansTax_74AC6A10506EFA0A3863EA6D6781FAEF" xlink:type="locator" />
    <presentationArc order="10" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_C435CDF1988BB858A0A4EA6D6780CEEC" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansTax_74AC6A10506EFA0A3863EA6D6781FAEF" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansNetOfTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansNetOfTax_05ADF554877B0EF4A4BEEA6D67810E2B" xlink:type="locator" />
    <presentationArc order="11" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_C435CDF1988BB858A0A4EA6D6780CEEC" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansNetOfTax_05ADF554877B0EF4A4BEEA6D67810E2B" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesBeforeTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesBeforeTax_059231418F288CF67B2AEA6D6781B522" xlink:type="locator" />
    <presentationArc order="12" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_C435CDF1988BB858A0A4EA6D6780CEEC" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesBeforeTax_059231418F288CF67B2AEA6D6781B522" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForWritedownOfSecuritiesBeforeTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForWritedownOfSecuritiesBeforeTax_17872B9657BCAFECBAC1EA6D6781B693" xlink:type="locator" />
    <presentationArc order="13" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_C435CDF1988BB858A0A4EA6D6780CEEC" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForWritedownOfSecuritiesBeforeTax_17872B9657BCAFECBAC1EA6D6781B693" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_OtherComprehensiveIncomeLossReclasificationAdjustmentfromAOCIAvailableforSaleSecuritiesbeforeTaxTotal" xlink:label="loc_lly_OtherComprehensiveIncomeLossReclasificationAdjustmentfromAOCIAvailableforSaleSecuritiesbeforeTaxTotal_2409F24FF23CA5105226EA6D67814068" xlink:type="locator" />
    <presentationArc order="14" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_C435CDF1988BB858A0A4EA6D6780CEEC" xlink:to="loc_lly_OtherComprehensiveIncomeLossReclasificationAdjustmentfromAOCIAvailableforSaleSecuritiesbeforeTaxTotal_2409F24FF23CA5105226EA6D67814068" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesTax_DE2DEC8F8CC828FAB26EEA6D6781103A" xlink:type="locator" />
    <presentationArc order="15" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_C435CDF1988BB858A0A4EA6D6780CEEC" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesTax_DE2DEC8F8CC828FAB26EEA6D6781103A" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_OtherComprehensiveIncomeLossReclassificationAdjustmentfromAOCIAvailableforSaleSecuritiesNetofTaxTotal" xlink:label="loc_lly_OtherComprehensiveIncomeLossReclassificationAdjustmentfromAOCIAvailableforSaleSecuritiesNetofTaxTotal_85CCE569090AE4751B11EA6D6782F958" xlink:type="locator" />
    <presentationArc order="16" preferredLabel="http://www.xbrl.org/2009/role/negatedTotalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_C435CDF1988BB858A0A4EA6D6780CEEC" xlink:to="loc_lly_OtherComprehensiveIncomeLossReclassificationAdjustmentfromAOCIAvailableforSaleSecuritiesNetofTaxTotal_85CCE569090AE4751B11EA6D6782F958" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OtherComprehensiveIncomeOtherNetOfTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeOtherNetOfTax_B7E9DB013EBE7BBD4372EA6D678267FD" xlink:type="locator" />
    <presentationArc order="17" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_C435CDF1988BB858A0A4EA6D6780CEEC" xlink:to="loc_us-gaap_OtherComprehensiveIncomeOtherNetOfTax_B7E9DB013EBE7BBD4372EA6D678267FD" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTax" xlink:label="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTax_D44E6D4FDD27F8C85D1AEA6D6782F62D" xlink:type="locator" />
    <presentationArc order="18" preferredLabel="http://www.xbrl.org/2009/role/negatedTotalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_C435CDF1988BB858A0A4EA6D6780CEEC" xlink:to="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTax_D44E6D4FDD27F8C85D1AEA6D6782F62D" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OtherComprehensiveIncomeUnrealizedGainLossOnDerivativesArisingDuringPeriodTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeUnrealizedGainLossOnDerivativesArisingDuringPeriodTax_2A510A868DD8C06DD29BEA6D67826B49" xlink:type="locator" />
    <presentationArc order="19" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_C435CDF1988BB858A0A4EA6D6780CEEC" xlink:to="loc_us-gaap_OtherComprehensiveIncomeUnrealizedGainLossOnDerivativesArisingDuringPeriodTax_2A510A868DD8C06DD29BEA6D67826B49" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansBeforeReclassificationAdjustmentsTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansBeforeReclassificationAdjustmentsTax_AF8AFF59381C85C2B7A3EA6D67829C9A" xlink:type="locator" />
    <presentationArc order="20" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_C435CDF1988BB858A0A4EA6D6780CEEC" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansBeforeReclassificationAdjustmentsTax_AF8AFF59381C85C2B7A3EA6D67829C9A" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossTax_96E62258893D3E2EE6BEEA6D678238C6" xlink:type="locator" />
    <presentationArc order="21" preferredLabel="http://www.xbrl.org/2009/role/negatedTotalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_C435CDF1988BB858A0A4EA6D6780CEEC" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossTax_96E62258893D3E2EE6BEEA6D678238C6" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.lilly.com/role/OtherComprehensiveIncomeLossTables" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossTaxAbstract" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossTaxAbstract_15DDF65F9130C7EFBAB8FC037127D250" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScheduleOfAmountsRecognizedInOtherComprehensiveIncomeLossTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfAmountsRecognizedInOtherComprehensiveIncomeLossTableTextBlock_96F8911A6DBE8E37080DFC037127C262" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossTaxAbstract_15DDF65F9130C7EFBAB8FC037127D250" xlink:to="loc_us-gaap_ScheduleOfAmountsRecognizedInOtherComprehensiveIncomeLossTableTextBlock_96F8911A6DBE8E37080DFC037127C262" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScheduleOfAccumulatedOtherComprehensiveIncomeLossTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfAccumulatedOtherComprehensiveIncomeLossTableTextBlock_5A00F9B6F702BC937B08FC037127829E" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossTaxAbstract_15DDF65F9130C7EFBAB8FC037127D250" xlink:to="loc_us-gaap_ScheduleOfAccumulatedOtherComprehensiveIncomeLossTableTextBlock_5A00F9B6F702BC937B08FC037127829E" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.lilly.com/role/OtherNetExpenseIncome" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_NonoperatingIncomeExpenseAbstract" xlink:label="loc_us-gaap_NonoperatingIncomeExpenseAbstract_F901775B51DC1E29BE96FC036ECF52D4" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OtherIncomeAndOtherExpenseDisclosureTextBlock" xlink:label="loc_us-gaap_OtherIncomeAndOtherExpenseDisclosureTextBlock_2CED0BDBF49FAE9C03E5FC036ECF53A6" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NonoperatingIncomeExpenseAbstract_F901775B51DC1E29BE96FC036ECF52D4" xlink:to="loc_us-gaap_OtherIncomeAndOtherExpenseDisclosureTextBlock_2CED0BDBF49FAE9C03E5FC036ECF53A6" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.lilly.com/role/OtherNetExpenseIncomeDetails" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_NonoperatingIncomeExpenseAbstract" xlink:label="loc_us-gaap_NonoperatingIncomeExpenseAbstract_62CBB2C385EBCF0AE3CDE731BC3C0184" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StatementTable" xlink:label="loc_us-gaap_StatementTable_175BC1B64275E1AC15D0E731BC3CEE95" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NonoperatingIncomeExpenseAbstract_62CBB2C385EBCF0AE3CDE731BC3C0184" xlink:to="loc_us-gaap_StatementTable_175BC1B64275E1AC15D0E731BC3CEE95" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ProductOrServiceAxis" xlink:label="loc_us-gaap_ProductOrServiceAxis_76A6201259CADA905F46E731BC3C567F" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_175BC1B64275E1AC15D0E731BC3CEE95" xlink:to="loc_us-gaap_ProductOrServiceAxis_76A6201259CADA905F46E731BC3C567F" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ProductsAndServicesDomain" xlink:label="loc_us-gaap_ProductsAndServicesDomain_4645AC775C929D10A526E731BC3C9DB7" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ProductOrServiceAxis_76A6201259CADA905F46E731BC3C567F" xlink:to="loc_us-gaap_ProductsAndServicesDomain_4645AC775C929D10A526E731BC3C9DB7" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_ExenatideMember" xlink:label="loc_lly_ExenatideMember_FF255E233EA9423C2989E731BC3C78E9" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ProductsAndServicesDomain_4645AC775C929D10A526E731BC3C9DB7" xlink:to="loc_lly_ExenatideMember_FF255E233EA9423C2989E731BC3C78E9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_139D6FEDCB1549EA9032E731BC3CF4DC" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_175BC1B64275E1AC15D0E731BC3CEE95" xlink:to="loc_us-gaap_StatementLineItems_139D6FEDCB1549EA9032E731BC3CF4DC" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OtherSalesRevenueNet" xlink:label="loc_us-gaap_OtherSalesRevenueNet_FEA60C1D51980C4E052CE731BC3CD19D" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_139D6FEDCB1549EA9032E731BC3CF4DC" xlink:to="loc_us-gaap_OtherSalesRevenueNet_FEA60C1D51980C4E052CE731BC3CD19D" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_GainLossOnContractTermination" xlink:label="loc_us-gaap_GainLossOnContractTermination_5A1596DE1D66A6313A25E731BC3C4239" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_139D6FEDCB1549EA9032E731BC3CF4DC" xlink:to="loc_us-gaap_GainLossOnContractTermination_5A1596DE1D66A6313A25E731BC3C4239" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_InterestExpense" xlink:label="loc_us-gaap_InterestExpense_E94BF930F5632871521DE731BC3C03EB" xlink:type="locator" />
    <presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_139D6FEDCB1549EA9032E731BC3CF4DC" xlink:to="loc_us-gaap_InterestExpense_E94BF930F5632871521DE731BC3C03EB" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_InvestmentIncomeInterest" xlink:label="loc_us-gaap_InvestmentIncomeInterest_903A1BAE5E6D41D5D1CAE731BC3C9D60" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_139D6FEDCB1549EA9032E731BC3CF4DC" xlink:to="loc_us-gaap_InvestmentIncomeInterest_903A1BAE5E6D41D5D1CAE731BC3C9D60" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_GainsLossesOnExtinguishmentOfDebt" xlink:label="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_47F83DBDF83EE3030332E731BC3DB249" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_139D6FEDCB1549EA9032E731BC3CF4DC" xlink:to="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_47F83DBDF83EE3030332E731BC3DB249" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OtherNonoperatingIncomeExpense" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_91093AB437A670777FA2E731BC3D8D8C" xlink:type="locator" />
    <presentationArc order="6" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_139D6FEDCB1549EA9032E731BC3CF4DC" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpense_91093AB437A670777FA2E731BC3D8D8C" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_NonoperatingIncomeExpense" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_D112D8EB3160A48339F9E731BC3D558D" xlink:type="locator" />
    <presentationArc order="7" preferredLabel="http://www.xbrl.org/2009/role/negatedTotalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_139D6FEDCB1549EA9032E731BC3CF4DC" xlink:to="loc_us-gaap_NonoperatingIncomeExpense_D112D8EB3160A48339F9E731BC3D558D" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.lilly.com/role/OtherNetExpenseIncomeTables" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_NonoperatingIncomeExpenseAbstract" xlink:label="loc_us-gaap_NonoperatingIncomeExpenseAbstract_C39F2D041C093D54784EFC036F1590C6" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScheduleOfOtherNonoperatingIncomeExpenseTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfOtherNonoperatingIncomeExpenseTableTextBlock_F86B7A4690EB3815AC6FFC036F159529" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NonoperatingIncomeExpenseAbstract_C39F2D041C093D54784EFC036F1590C6" xlink:to="loc_us-gaap_ScheduleOfOtherNonoperatingIncomeExpenseTableTextBlock_F86B7A4690EB3815AC6FFC036F159529" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.lilly.com/role/PropertyAndEquipmentDetails" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PropertyPlantAndEquipmentAbstract" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentAbstract_3D74A28330D05B665E10F6A367C5A57D" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScheduleOfPropertyPlantAndEquipmentTable" xlink:label="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_942081283C3C5870A8EDF5374A0E0322" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentAbstract_3D74A28330D05B665E10F6A367C5A57D" xlink:to="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_942081283C3C5870A8EDF5374A0E0322" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PropertyPlantAndEquipmentByTypeAxis" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_5764ADB3CD16A9AD1D62F5374A0E9101" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_942081283C3C5870A8EDF5374A0E0322" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_5764ADB3CD16A9AD1D62F5374A0E9101" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_1ECE9D534EB8399FD905F5374A0EA64C" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_5764ADB3CD16A9AD1D62F5374A0E9101" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_1ECE9D534EB8399FD905F5374A0EA64C" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_BuildingMember" xlink:label="loc_us-gaap_BuildingMember_F014A22CE2CC5FD23012F5374A0EB983" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_1ECE9D534EB8399FD905F5374A0EA64C" xlink:to="loc_us-gaap_BuildingMember_F014A22CE2CC5FD23012F5374A0EB983" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_EquipmentMember" xlink:label="loc_us-gaap_EquipmentMember_696C7BA3F0F598974C06F5374A0E228D" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_1ECE9D534EB8399FD905F5374A0EA64C" xlink:to="loc_us-gaap_EquipmentMember_696C7BA3F0F598974C06F5374A0E228D" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_RangeAxis" xlink:label="loc_us-gaap_RangeAxis_2CB9E88167E4489D255AF5374A0EA608" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_942081283C3C5870A8EDF5374A0E0322" xlink:to="loc_us-gaap_RangeAxis_2CB9E88167E4489D255AF5374A0EA608" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_RangeMember" xlink:label="loc_us-gaap_RangeMember_180BE56B012170C82AFAF5374A0ECC63" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RangeAxis_2CB9E88167E4489D255AF5374A0EA608" xlink:to="loc_us-gaap_RangeMember_180BE56B012170C82AFAF5374A0ECC63" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_MinimumMember" xlink:label="loc_us-gaap_MinimumMember_899553F4A990753EDB83F5374A0F7C30" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RangeMember_180BE56B012170C82AFAF5374A0ECC63" xlink:to="loc_us-gaap_MinimumMember_899553F4A990753EDB83F5374A0F7C30" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_MaximumMember" xlink:label="loc_us-gaap_MaximumMember_DA8A5645D511FAE73D0FF5374A0F2729" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RangeMember_180BE56B012170C82AFAF5374A0ECC63" xlink:to="loc_us-gaap_MaximumMember_DA8A5645D511FAE73D0FF5374A0F2729" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PropertyPlantAndEquipmentLineItems" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentLineItems_F858C759B65D1B164903F5374A0FED91" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_942081283C3C5870A8EDF5374A0E0322" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentLineItems_F858C759B65D1B164903F5374A0FED91" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PropertyPlantAndEquipmentUsefulLife" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentUsefulLife_B4D26F83E64821B31DD1F5374A0FC263" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_F858C759B65D1B164903F5374A0FED91" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentUsefulLife_B4D26F83E64821B31DD1F5374A0FC263" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_Depreciation" xlink:label="loc_us-gaap_Depreciation_B808339DE880310A4E49F5374A0FD0E9" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentAbstract_3D74A28330D05B665E10F6A367C5A57D" xlink:to="loc_us-gaap_Depreciation_B808339DE880310A4E49F5374A0FD0E9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_Land" xlink:label="loc_us-gaap_Land_0C0A40FDA850FB97C695F5374A0F933C" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentAbstract_3D74A28330D05B665E10F6A367C5A57D" xlink:to="loc_us-gaap_Land_0C0A40FDA850FB97C695F5374A0F933C" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_BuildingsAndImprovementsGross" xlink:label="loc_us-gaap_BuildingsAndImprovementsGross_0172B89FE794637DB547F5374A0F3DFE" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentAbstract_3D74A28330D05B665E10F6A367C5A57D" xlink:to="loc_us-gaap_BuildingsAndImprovementsGross_0172B89FE794637DB547F5374A0F3DFE" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_MachineryAndEquipmentGross" xlink:label="loc_us-gaap_MachineryAndEquipmentGross_7E464A4DE1AF58D0BC4FF5374A0F1981" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentAbstract_3D74A28330D05B665E10F6A367C5A57D" xlink:to="loc_us-gaap_MachineryAndEquipmentGross_7E464A4DE1AF58D0BC4FF5374A0F1981" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ConstructionInProgressGross" xlink:label="loc_us-gaap_ConstructionInProgressGross_1AD6A09D0E6614FD5C0DF5374A0F1A23" xlink:type="locator" />
    <presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentAbstract_3D74A28330D05B665E10F6A367C5A57D" xlink:to="loc_us-gaap_ConstructionInProgressGross_1AD6A09D0E6614FD5C0DF5374A0F1A23" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PropertyPlantAndEquipmentGross" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentGross_FBBB734D64554806009AF5374A0F42DF" xlink:type="locator" />
    <presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentAbstract_3D74A28330D05B665E10F6A367C5A57D" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentGross_FBBB734D64554806009AF5374A0F42DF" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment" xlink:label="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_0B6E117E4396D554FD04F5374A0FBCA1" xlink:type="locator" />
    <presentationArc order="8" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentAbstract_3D74A28330D05B665E10F6A367C5A57D" xlink:to="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_0B6E117E4396D554FD04F5374A0FBCA1" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PropertyPlantAndEquipmentNet" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_DF8CA7FFE1AE6438E4E8F5374A0F07FB" xlink:type="locator" />
    <presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentAbstract_3D74A28330D05B665E10F6A367C5A57D" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_DF8CA7FFE1AE6438E4E8F5374A0F07FB" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_LeaseAndRentalExpense" xlink:label="loc_us-gaap_LeaseAndRentalExpense_8331478CD4B4AF01AF3AF5374A0FC2BC" xlink:type="locator" />
    <presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentAbstract_3D74A28330D05B665E10F6A367C5A57D" xlink:to="loc_us-gaap_LeaseAndRentalExpense_8331478CD4B4AF01AF3AF5374A0FC2BC" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.lilly.com/role/PropertyAndEquipmentNotes" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PropertyPlantAndEquipmentAbstract" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentAbstract_5959CA4F1928FE6D05EDFC036F01DD59" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PropertyPlantAndEquipmentDisclosureTextBlock" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentDisclosureTextBlock_BD53672E49362AE134FAFC036F0120B5" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentAbstract_5959CA4F1928FE6D05EDFC036F01DD59" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentDisclosureTextBlock_BD53672E49362AE134FAFC036F0120B5" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.lilly.com/role/PropertyAndEquipmentPropertyAndEquipmentPolicies" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PropertyPlantAndEquipmentAbstract" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentAbstract_672556517B7CA0CFFD1BFC036F15D692" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PropertyPlantAndEquipmentPolicyTextBlock" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentPolicyTextBlock_6FAF000AEAF2DC750BFBFC036F1569AD" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentAbstract_672556517B7CA0CFFD1BFC036F15D692" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentPolicyTextBlock_6FAF000AEAF2DC750BFBFC036F1569AD" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.lilly.com/role/PropertyAndEquipmentTables" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PropertyPlantAndEquipmentAbstract" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentAbstract_65B5363DED98436FD40DCE762CE48E59" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScheduleOfPropertyPlantAndEquipmentTable" xlink:label="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_2793D563D3483306614ACE762CE4D138" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentAbstract_65B5363DED98436FD40DCE762CE48E59" xlink:to="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_2793D563D3483306614ACE762CE4D138" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PropertyPlantAndEquipmentByTypeAxis" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_0C49CED5C5D42A575C2ACE762CE49682" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_2793D563D3483306614ACE762CE4D138" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_0C49CED5C5D42A575C2ACE762CE49682" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_82953E3838E5BAAD1F50CE762CE4C6BB" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_0C49CED5C5D42A575C2ACE762CE49682" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_82953E3838E5BAAD1F50CE762CE4C6BB" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_RangeAxis" xlink:label="loc_us-gaap_RangeAxis_990724A76579AA2E43BCCE762CE41875" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_2793D563D3483306614ACE762CE4D138" xlink:to="loc_us-gaap_RangeAxis_990724A76579AA2E43BCCE762CE41875" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_RangeMember" xlink:label="loc_us-gaap_RangeMember_D103D8B23E35E8901224CE762CE49ED8" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RangeAxis_990724A76579AA2E43BCCE762CE41875" xlink:to="loc_us-gaap_RangeMember_D103D8B23E35E8901224CE762CE49ED8" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PropertyPlantAndEquipmentLineItems" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentLineItems_94329D51C57B0E12D41ACE762CE59390" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_2793D563D3483306614ACE762CE4D138" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentLineItems_94329D51C57B0E12D41ACE762CE59390" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PropertyPlantAndEquipmentTextBlock" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTextBlock_4E6897261164214231C4CE762CE5BD30" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_94329D51C57B0E12D41ACE762CE59390" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTextBlock_4E6897261164214231C4CE762CE5BD30" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScheduleOfRentExpenseTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfRentExpenseTableTextBlock_D957BBBB73A631129D9ACE7853DD6A1D" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_94329D51C57B0E12D41ACE762CE59390" xlink:to="loc_us-gaap_ScheduleOfRentExpenseTableTextBlock_D957BBBB73A631129D9ACE7853DD6A1D" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.lilly.com/role/RetirementBenefits" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansDisclosuresAbstract" xlink:label="loc_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansDisclosuresAbstract_ACF160D29437F69B6CE8FC036ECFD019" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PensionAndOtherPostretirementBenefitsDisclosureTextBlock" xlink:label="loc_us-gaap_PensionAndOtherPostretirementBenefitsDisclosureTextBlock_0D1D72E73CFB664EFA83FC036ECF5041" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansDisclosuresAbstract_ACF160D29437F69B6CE8FC036ECFD019" xlink:to="loc_us-gaap_PensionAndOtherPostretirementBenefitsDisclosureTextBlock_0D1D72E73CFB664EFA83FC036ECF5041" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.lilly.com/role/RetirementBenefitsFairValueDisclosuresDetails" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansDisclosuresAbstract" xlink:label="loc_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansDisclosuresAbstract_E855D03A8778734DDE70FC036E89DD48" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansDisclosuresTable" xlink:label="loc_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansDisclosuresTable_12954C5FA7C04D5A9430FC036E890AAC" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansDisclosuresAbstract_E855D03A8778734DDE70FC036E89DD48" xlink:to="loc_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansDisclosuresTable_12954C5FA7C04D5A9430FC036E890AAC" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_7095D7A442B4B1F8ABC6FC036E8973F7" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansDisclosuresTable_12954C5FA7C04D5A9430FC036E890AAC" xlink:to="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_7095D7A442B4B1F8ABC6FC036E8973F7" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_118770164A772EF12D26FC036E89CB3F" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_7095D7A442B4B1F8ABC6FC036E8973F7" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_118770164A772EF12D26FC036E89CB3F" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FairValueInputsLevel1Member" xlink:label="loc_us-gaap_FairValueInputsLevel1Member_9BF2F03BD9F8F58BF65BFC036E89B078" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_118770164A772EF12D26FC036E89CB3F" xlink:to="loc_us-gaap_FairValueInputsLevel1Member_9BF2F03BD9F8F58BF65BFC036E89B078" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FairValueInputsLevel2Member" xlink:label="loc_us-gaap_FairValueInputsLevel2Member_4CD3AB96BD080D736589FC036E896EF1" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_118770164A772EF12D26FC036E89CB3F" xlink:to="loc_us-gaap_FairValueInputsLevel2Member_4CD3AB96BD080D736589FC036E896EF1" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FairValueInputsLevel3Member" xlink:label="loc_us-gaap_FairValueInputsLevel3Member_CFC4FBA713F02DB8A99EFC036E89F517" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_118770164A772EF12D26FC036E89CB3F" xlink:to="loc_us-gaap_FairValueInputsLevel3Member_CFC4FBA713F02DB8A99EFC036E89F517" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DefinedBenefitPlanByPlanAssetCategoriesAxis" xlink:label="loc_us-gaap_DefinedBenefitPlanByPlanAssetCategoriesAxis_BC04118E53F3F4B4A82BFC036E89228D" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansDisclosuresTable_12954C5FA7C04D5A9430FC036E890AAC" xlink:to="loc_us-gaap_DefinedBenefitPlanByPlanAssetCategoriesAxis_BC04118E53F3F4B4A82BFC036E89228D" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PlanAssetCategoriesDomain" xlink:label="loc_us-gaap_PlanAssetCategoriesDomain_39AB531938B4D3263694FC036E89CDE5" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DefinedBenefitPlanByPlanAssetCategoriesAxis_BC04118E53F3F4B4A82BFC036E89228D" xlink:to="loc_us-gaap_PlanAssetCategoriesDomain_39AB531938B4D3263694FC036E89CDE5" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FixedIncomeFundsMember" xlink:label="loc_us-gaap_FixedIncomeFundsMember_845557382234B4A618EFFC036E89F584" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PlanAssetCategoriesDomain_39AB531938B4D3263694FC036E89CDE5" xlink:to="loc_us-gaap_FixedIncomeFundsMember_845557382234B4A618EFFC036E89F584" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_FixedIncomeFundsDevelopedMarketsMember" xlink:label="loc_lly_FixedIncomeFundsDevelopedMarketsMember_E76A712F8F92AF1CBB53FC036E891238" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PlanAssetCategoriesDomain_39AB531938B4D3263694FC036E89CDE5" xlink:to="loc_lly_FixedIncomeFundsDevelopedMarketsMember_E76A712F8F92AF1CBB53FC036E891238" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_EquityFundsMember" xlink:label="loc_us-gaap_EquityFundsMember_BED753C44109B7E184C6FC036E89E67E" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PlanAssetCategoriesDomain_39AB531938B4D3263694FC036E89CDE5" xlink:to="loc_us-gaap_EquityFundsMember_BED753C44109B7E184C6FC036E89E67E" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_EquitySecuritiesMember" xlink:label="loc_us-gaap_EquitySecuritiesMember_14E09F5017603B4A0509FC036E8954DE" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PlanAssetCategoriesDomain_39AB531938B4D3263694FC036E89CDE5" xlink:to="loc_us-gaap_EquitySecuritiesMember_14E09F5017603B4A0509FC036E8954DE" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_EquitySecuritiesInternationalMember" xlink:label="loc_lly_EquitySecuritiesInternationalMember_0EE107BCEE98B44A9AE5FC036E89AC2C" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PlanAssetCategoriesDomain_39AB531938B4D3263694FC036E89CDE5" xlink:to="loc_lly_EquitySecuritiesInternationalMember_0EE107BCEE98B44A9AE5FC036E89AC2C" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_FixedIncomeFundsEmergingMarketsMember" xlink:label="loc_lly_FixedIncomeFundsEmergingMarketsMember_29F36CCA9337A3D78DF7FC036E896753" xlink:type="locator" />
    <presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PlanAssetCategoriesDomain_39AB531938B4D3263694FC036E89CDE5" xlink:to="loc_lly_FixedIncomeFundsEmergingMarketsMember_29F36CCA9337A3D78DF7FC036E896753" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_HedgeFundsMember" xlink:label="loc_us-gaap_HedgeFundsMember_C137EC9DF50737FADE3BFC036E89941C" xlink:type="locator" />
    <presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PlanAssetCategoriesDomain_39AB531938B4D3263694FC036E89CDE5" xlink:to="loc_us-gaap_HedgeFundsMember_C137EC9DF50737FADE3BFC036E89941C" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_RealEstateMember" xlink:label="loc_us-gaap_RealEstateMember_B4E023AD2D225BE2CBD9FC036E89E0B5" xlink:type="locator" />
    <presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PlanAssetCategoriesDomain_39AB531938B4D3263694FC036E89CDE5" xlink:to="loc_us-gaap_RealEstateMember_B4E023AD2D225BE2CBD9FC036E89E0B5" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OtherAssetsMember" xlink:label="loc_us-gaap_OtherAssetsMember_40D55D797BF0477DC424FC036E899BE2" xlink:type="locator" />
    <presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PlanAssetCategoriesDomain_39AB531938B4D3263694FC036E89CDE5" xlink:to="loc_us-gaap_OtherAssetsMember_40D55D797BF0477DC424FC036E899BE2" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OtherContractMember" xlink:label="loc_us-gaap_OtherContractMember_FFDBA9F7595EACBCF3DFFC036E893D95" xlink:type="locator" />
    <presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PlanAssetCategoriesDomain_39AB531938B4D3263694FC036E89CDE5" xlink:to="loc_us-gaap_OtherContractMember_FFDBA9F7595EACBCF3DFFC036E893D95" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DefinedBenefitPlansDisclosuresDefinedBenefitPlansAxis" xlink:label="loc_us-gaap_DefinedBenefitPlansDisclosuresDefinedBenefitPlansAxis_231DE50546B7B9687AFFFC036E895901" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansDisclosuresTable_12954C5FA7C04D5A9430FC036E890AAC" xlink:to="loc_us-gaap_DefinedBenefitPlansDisclosuresDefinedBenefitPlansAxis_231DE50546B7B9687AFFFC036E895901" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DefinedBenefitPlansDomain" xlink:label="loc_us-gaap_DefinedBenefitPlansDomain_0CB0DCBD29A80A254A6DFC036E8926C0" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DefinedBenefitPlansDisclosuresDefinedBenefitPlansAxis_231DE50546B7B9687AFFFC036E895901" xlink:to="loc_us-gaap_DefinedBenefitPlansDomain_0CB0DCBD29A80A254A6DFC036E8926C0" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OtherPostretirementBenefitPlansDefinedBenefitMember" xlink:label="loc_us-gaap_OtherPostretirementBenefitPlansDefinedBenefitMember_D869F2ED8E294461B6C1FC036E89FCCE" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DefinedBenefitPlansDomain_0CB0DCBD29A80A254A6DFC036E8926C0" xlink:to="loc_us-gaap_OtherPostretirementBenefitPlansDefinedBenefitMember_D869F2ED8E294461B6C1FC036E89FCCE" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PensionPlansDefinedBenefitMember" xlink:label="loc_us-gaap_PensionPlansDefinedBenefitMember_C19362A174F73594C2BEFC036E89528A" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DefinedBenefitPlansDomain_0CB0DCBD29A80A254A6DFC036E8926C0" xlink:to="loc_us-gaap_PensionPlansDefinedBenefitMember_C19362A174F73594C2BEFC036E89528A" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_564C6521F1296B92A67EFC036E899CAD" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansDisclosuresTable_12954C5FA7C04D5A9430FC036E890AAC" xlink:to="loc_us-gaap_StatementLineItems_564C6521F1296B92A67EFC036E899CAD" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_DefinedBenefitPlanPercentageOfGlobalInvestmentsInPlanAssets" xlink:label="loc_lly_DefinedBenefitPlanPercentageOfGlobalInvestmentsInPlanAssets_A0CFD2BE215E2300EE9FFC036E8981A9" xlink:type="locator" />
    <presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_564C6521F1296B92A67EFC036E899CAD" xlink:to="loc_lly_DefinedBenefitPlanPercentageOfGlobalInvestmentsInPlanAssets_A0CFD2BE215E2300EE9FFC036E8981A9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DefinedBenefitPlanTargetPlanAssetAllocations" xlink:label="loc_us-gaap_DefinedBenefitPlanTargetPlanAssetAllocations_F6A3A2F919009AA00D3AFC036E8912EA" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_564C6521F1296B92A67EFC036E899CAD" xlink:to="loc_us-gaap_DefinedBenefitPlanTargetPlanAssetAllocations_F6A3A2F919009AA00D3AFC036E8912EA" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DefinedBenefitPlanFairValueOfPlanAssets" xlink:label="loc_us-gaap_DefinedBenefitPlanFairValueOfPlanAssets_5CBD86519279109A666EFC036E894A43" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_564C6521F1296B92A67EFC036E899CAD" xlink:to="loc_us-gaap_DefinedBenefitPlanFairValueOfPlanAssets_5CBD86519279109A666EFC036E894A43" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DefinedBenefitPlanFairValueOfPlanAssets" xlink:label="loc_us-gaap_DefinedBenefitPlanFairValueOfPlanAssets_B813DCE24BCA0ED661F5FC036E8956B9" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_564C6521F1296B92A67EFC036E899CAD" xlink:to="loc_us-gaap_DefinedBenefitPlanFairValueOfPlanAssets_B813DCE24BCA0ED661F5FC036E8956B9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DefinedBenefitPlanActualReturnOnPlanAssetsStillHeld" xlink:label="loc_us-gaap_DefinedBenefitPlanActualReturnOnPlanAssetsStillHeld_23D86947242BBC4C2734FC036E89F7BD" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_564C6521F1296B92A67EFC036E899CAD" xlink:to="loc_us-gaap_DefinedBenefitPlanActualReturnOnPlanAssetsStillHeld_23D86947242BBC4C2734FC036E89F7BD" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DefinedBenefitPlanActualReturnOnPlanAssetsSoldDuringPeriod" xlink:label="loc_us-gaap_DefinedBenefitPlanActualReturnOnPlanAssetsSoldDuringPeriod_482349092F2058934FA7FC036E8954EF" xlink:type="locator" />
    <presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_564C6521F1296B92A67EFC036E899CAD" xlink:to="loc_us-gaap_DefinedBenefitPlanActualReturnOnPlanAssetsSoldDuringPeriod_482349092F2058934FA7FC036E8954EF" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DefinedBenefitPlanPurchasesSalesAndSettlements" xlink:label="loc_us-gaap_DefinedBenefitPlanPurchasesSalesAndSettlements_36C64879F534ED8FFA6CFC036E89E930" xlink:type="locator" />
    <presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_564C6521F1296B92A67EFC036E899CAD" xlink:to="loc_us-gaap_DefinedBenefitPlanPurchasesSalesAndSettlements_36C64879F534ED8FFA6CFC036E89E930" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DefinedBenefitPlanBusinessCombinationsAndAcquisitionsPlanAssets" xlink:label="loc_us-gaap_DefinedBenefitPlanBusinessCombinationsAndAcquisitionsPlanAssets_EAC31B1E7CED52A6140BFC036E896F46" xlink:type="locator" />
    <presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_564C6521F1296B92A67EFC036E899CAD" xlink:to="loc_us-gaap_DefinedBenefitPlanBusinessCombinationsAndAcquisitionsPlanAssets_EAC31B1E7CED52A6140BFC036E896F46" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DefinedBenefitPlanTransfersBetweenMeasurementLevels" xlink:label="loc_us-gaap_DefinedBenefitPlanTransfersBetweenMeasurementLevels_004FE709B920CE58F1E5FC036E89EDE7" xlink:type="locator" />
    <presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_564C6521F1296B92A67EFC036E899CAD" xlink:to="loc_us-gaap_DefinedBenefitPlanTransfersBetweenMeasurementLevels_004FE709B920CE58F1E5FC036E89EDE7" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.lilly.com/role/RetirementBenefitsScheduleOfBenefitObligationsAndPlanAssetsDetails" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansDisclosuresAbstract" xlink:label="loc_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansDisclosuresAbstract_E825240021C59329A947F53749834F6E" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansDisclosuresTable" xlink:label="loc_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansDisclosuresTable_9D4B472BC1FD17B80C78F5374983D516" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansDisclosuresAbstract_E825240021C59329A947F53749834F6E" xlink:to="loc_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansDisclosuresTable_9D4B472BC1FD17B80C78F5374983D516" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DefinedBenefitPlanByPlanAssetCategoriesAxis" xlink:label="loc_us-gaap_DefinedBenefitPlanByPlanAssetCategoriesAxis_B2EEF465F48069F1F217F53749830B84" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansDisclosuresTable_9D4B472BC1FD17B80C78F5374983D516" xlink:to="loc_us-gaap_DefinedBenefitPlanByPlanAssetCategoriesAxis_B2EEF465F48069F1F217F53749830B84" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PlanAssetCategoriesDomain" xlink:label="loc_us-gaap_PlanAssetCategoriesDomain_6955293E76E18495E40DF53749837A17" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DefinedBenefitPlanByPlanAssetCategoriesAxis_B2EEF465F48069F1F217F53749830B84" xlink:to="loc_us-gaap_PlanAssetCategoriesDomain_6955293E76E18495E40DF53749837A17" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_EquitySecuritiesMember" xlink:label="loc_us-gaap_EquitySecuritiesMember_5F3F8F9062C9D7A823ACF53749831550" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PlanAssetCategoriesDomain_6955293E76E18495E40DF53749837A17" xlink:to="loc_us-gaap_EquitySecuritiesMember_5F3F8F9062C9D7A823ACF53749831550" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_EquitySecuritiesInternationalMember" xlink:label="loc_lly_EquitySecuritiesInternationalMember_4DB89A364F744D33D6B7F5374984E947" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PlanAssetCategoriesDomain_6955293E76E18495E40DF53749837A17" xlink:to="loc_lly_EquitySecuritiesInternationalMember_4DB89A364F744D33D6B7F5374984E947" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_FixedIncomeFundsDevelopedMarketsMember" xlink:label="loc_lly_FixedIncomeFundsDevelopedMarketsMember_E11AA61DB3019B92734FF5374984D75F" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PlanAssetCategoriesDomain_6955293E76E18495E40DF53749837A17" xlink:to="loc_lly_FixedIncomeFundsDevelopedMarketsMember_E11AA61DB3019B92734FF5374984D75F" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_F22FC6CF2571B4D23B35F537498439F6" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansDisclosuresTable_9D4B472BC1FD17B80C78F5374983D516" xlink:to="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_F22FC6CF2571B4D23B35F537498439F6" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_824DA492DE43C42FEBB7F53749848425" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_F22FC6CF2571B4D23B35F537498439F6" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_824DA492DE43C42FEBB7F53749848425" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FairValueInputsLevel2Member" xlink:label="loc_us-gaap_FairValueInputsLevel2Member_D93BEB9DA1C821929D85F5374984B253" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_824DA492DE43C42FEBB7F53749848425" xlink:to="loc_us-gaap_FairValueInputsLevel2Member_D93BEB9DA1C821929D85F5374984B253" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FairValueInputsLevel3Member" xlink:label="loc_us-gaap_FairValueInputsLevel3Member_53124C69EC43317F9C2EF53749842DB4" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_824DA492DE43C42FEBB7F53749848425" xlink:to="loc_us-gaap_FairValueInputsLevel3Member_53124C69EC43317F9C2EF53749842DB4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FairValueInputsLevel1Member" xlink:label="loc_us-gaap_FairValueInputsLevel1Member_4C4809323D43B836337DF53749848021" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_824DA492DE43C42FEBB7F53749848425" xlink:to="loc_us-gaap_FairValueInputsLevel1Member_4C4809323D43B836337DF53749848021" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DefinedBenefitPlansDisclosuresDefinedBenefitPlansAxis" xlink:label="loc_us-gaap_DefinedBenefitPlansDisclosuresDefinedBenefitPlansAxis_00F1ADCA755FC4668A83F537498446E2" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansDisclosuresTable_9D4B472BC1FD17B80C78F5374983D516" xlink:to="loc_us-gaap_DefinedBenefitPlansDisclosuresDefinedBenefitPlansAxis_00F1ADCA755FC4668A83F537498446E2" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DefinedBenefitPlansDomain" xlink:label="loc_us-gaap_DefinedBenefitPlansDomain_F7BD8DCE7B5425F1A7A4F537498407E8" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DefinedBenefitPlansDisclosuresDefinedBenefitPlansAxis_00F1ADCA755FC4668A83F537498446E2" xlink:to="loc_us-gaap_DefinedBenefitPlansDomain_F7BD8DCE7B5425F1A7A4F537498407E8" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PensionPlansDefinedBenefitMember" xlink:label="loc_us-gaap_PensionPlansDefinedBenefitMember_832848AE246366ED3ED6F5374985F3AE" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DefinedBenefitPlansDomain_F7BD8DCE7B5425F1A7A4F537498407E8" xlink:to="loc_us-gaap_PensionPlansDefinedBenefitMember_832848AE246366ED3ED6F5374985F3AE" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OtherPostretirementBenefitPlansDefinedBenefitMember" xlink:label="loc_us-gaap_OtherPostretirementBenefitPlansDefinedBenefitMember_13EFBB77E0BE6E7BD9B3F5374985AB99" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DefinedBenefitPlansDomain_F7BD8DCE7B5425F1A7A4F537498407E8" xlink:to="loc_us-gaap_OtherPostretirementBenefitPlansDefinedBenefitMember_13EFBB77E0BE6E7BD9B3F5374985AB99" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_6DD46F153D74C3ABBD82F5374985CEBE" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansDisclosuresTable_9D4B472BC1FD17B80C78F5374983D516" xlink:to="loc_us-gaap_StatementLineItems_6DD46F153D74C3ABBD82F5374985CEBE" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DefinedBenefitPlanBusinessCombinationsAndAcquisitionsBenefitObligation" xlink:label="loc_us-gaap_DefinedBenefitPlanBusinessCombinationsAndAcquisitionsBenefitObligation_BDA20F9D4E0FF9280F71F5374985280D" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_6DD46F153D74C3ABBD82F5374985CEBE" xlink:to="loc_us-gaap_DefinedBenefitPlanBusinessCombinationsAndAcquisitionsBenefitObligation_BDA20F9D4E0FF9280F71F5374985280D" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DefinedBenefitPlanBenefitObligation" xlink:label="loc_us-gaap_DefinedBenefitPlanBenefitObligation_B36B2328B46CA28B4930F5374985C975" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_6DD46F153D74C3ABBD82F5374985CEBE" xlink:to="loc_us-gaap_DefinedBenefitPlanBenefitObligation_B36B2328B46CA28B4930F5374985C975" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DefinedBenefitPlanServiceCost" xlink:label="loc_us-gaap_DefinedBenefitPlanServiceCost_E86379A9CAB4BBD932BDF53749859E0F" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_6DD46F153D74C3ABBD82F5374985CEBE" xlink:to="loc_us-gaap_DefinedBenefitPlanServiceCost_E86379A9CAB4BBD932BDF53749859E0F" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DefinedBenefitPlanInterestCost" xlink:label="loc_us-gaap_DefinedBenefitPlanInterestCost_E67EB12A628503B259EAF537498A8DAE" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_6DD46F153D74C3ABBD82F5374985CEBE" xlink:to="loc_us-gaap_DefinedBenefitPlanInterestCost_E67EB12A628503B259EAF537498A8DAE" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DefinedBenefitPlanActuarialGainLoss" xlink:label="loc_us-gaap_DefinedBenefitPlanActuarialGainLoss_309CEA534CA54D387DE1F537498A85FD" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_6DD46F153D74C3ABBD82F5374985CEBE" xlink:to="loc_us-gaap_DefinedBenefitPlanActuarialGainLoss_309CEA534CA54D387DE1F537498A85FD" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DefinedBenefitPlanBenefitsPaid" xlink:label="loc_us-gaap_DefinedBenefitPlanBenefitsPaid_349C3E04FCCE918E39E8F537498A4293" xlink:type="locator" />
    <presentationArc order="6" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_6DD46F153D74C3ABBD82F5374985CEBE" xlink:to="loc_us-gaap_DefinedBenefitPlanBenefitsPaid_349C3E04FCCE918E39E8F537498A4293" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DefinedBenefitPlanPlanAmendments" xlink:label="loc_us-gaap_DefinedBenefitPlanPlanAmendments_263FCB038255ED2A6187F537498A7888" xlink:type="locator" />
    <presentationArc order="7" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_6DD46F153D74C3ABBD82F5374985CEBE" xlink:to="loc_us-gaap_DefinedBenefitPlanPlanAmendments_263FCB038255ED2A6187F537498A7888" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DefinedBenefitPlanForeignCurrencyExchangeRateChangesBenefitObligation" xlink:label="loc_us-gaap_DefinedBenefitPlanForeignCurrencyExchangeRateChangesBenefitObligation_B84CAA8C3C85F7727118F537498A6137" xlink:type="locator" />
    <presentationArc order="8" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_6DD46F153D74C3ABBD82F5374985CEBE" xlink:to="loc_us-gaap_DefinedBenefitPlanForeignCurrencyExchangeRateChangesBenefitObligation_B84CAA8C3C85F7727118F537498A6137" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DefinedBenefitPlanBenefitObligation" xlink:label="loc_us-gaap_DefinedBenefitPlanBenefitObligation_42DE2F234CFCD8EBA506F537498A4F97" xlink:type="locator" />
    <presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_6DD46F153D74C3ABBD82F5374985CEBE" xlink:to="loc_us-gaap_DefinedBenefitPlanBenefitObligation_42DE2F234CFCD8EBA506F537498A4F97" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DefinedBenefitPlanFairValueOfPlanAssets" xlink:label="loc_us-gaap_DefinedBenefitPlanFairValueOfPlanAssets_56469E1C4522A6DD6775F537498AFE1F" xlink:type="locator" />
    <presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_6DD46F153D74C3ABBD82F5374985CEBE" xlink:to="loc_us-gaap_DefinedBenefitPlanFairValueOfPlanAssets_56469E1C4522A6DD6775F537498AFE1F" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DefinedBenefitPlanActualReturnOnPlanAssets" xlink:label="loc_us-gaap_DefinedBenefitPlanActualReturnOnPlanAssets_14E7947E39B441D4A663F537498A8C2C" xlink:type="locator" />
    <presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_6DD46F153D74C3ABBD82F5374985CEBE" xlink:to="loc_us-gaap_DefinedBenefitPlanActualReturnOnPlanAssets_14E7947E39B441D4A663F537498A8C2C" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DefinedBenefitPlanContributionsByEmployer" xlink:label="loc_us-gaap_DefinedBenefitPlanContributionsByEmployer_6B80D1338CF7A703E619F537498AEF4E" xlink:type="locator" />
    <presentationArc order="12" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_6DD46F153D74C3ABBD82F5374985CEBE" xlink:to="loc_us-gaap_DefinedBenefitPlanContributionsByEmployer_6B80D1338CF7A703E619F537498AEF4E" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DefinedBenefitPlanForeignCurrencyExchangeRateChangesPlanAssets" xlink:label="loc_us-gaap_DefinedBenefitPlanForeignCurrencyExchangeRateChangesPlanAssets_918512B966419ACB726AF537498B670F" xlink:type="locator" />
    <presentationArc order="13" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_6DD46F153D74C3ABBD82F5374985CEBE" xlink:to="loc_us-gaap_DefinedBenefitPlanForeignCurrencyExchangeRateChangesPlanAssets_918512B966419ACB726AF537498B670F" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DefinedBenefitPlanFairValueOfPlanAssets" xlink:label="loc_us-gaap_DefinedBenefitPlanFairValueOfPlanAssets_0D2A2BC465085664B2AFF537498B1E66" xlink:type="locator" />
    <presentationArc order="14" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_6DD46F153D74C3ABBD82F5374985CEBE" xlink:to="loc_us-gaap_DefinedBenefitPlanFairValueOfPlanAssets_0D2A2BC465085664B2AFF537498B1E66" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DefinedBenefitPlanFundedStatusOfPlan" xlink:label="loc_us-gaap_DefinedBenefitPlanFundedStatusOfPlan_4B86F31145D1BFA7571AF537498B5D49" xlink:type="locator" />
    <presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_6DD46F153D74C3ABBD82F5374985CEBE" xlink:to="loc_us-gaap_DefinedBenefitPlanFundedStatusOfPlan_4B86F31145D1BFA7571AF537498B5D49" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DefinedBenefitPlanAccumulatedOtherComprehensiveIncomeNetGainsLossesBeforeTax" xlink:label="loc_us-gaap_DefinedBenefitPlanAccumulatedOtherComprehensiveIncomeNetGainsLossesBeforeTax_F232661D38141E903D90F537498BC3F7" xlink:type="locator" />
    <presentationArc order="16" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_6DD46F153D74C3ABBD82F5374985CEBE" xlink:to="loc_us-gaap_DefinedBenefitPlanAccumulatedOtherComprehensiveIncomeNetGainsLossesBeforeTax_F232661D38141E903D90F537498BC3F7" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DefinedBenefitPlanAccumulatedOtherComprehensiveIncomeNetPriorServiceCostCreditBeforeTax" xlink:label="loc_us-gaap_DefinedBenefitPlanAccumulatedOtherComprehensiveIncomeNetPriorServiceCostCreditBeforeTax_D8C33E8748A9552A78B8F537498BC031" xlink:type="locator" />
    <presentationArc order="17" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_6DD46F153D74C3ABBD82F5374985CEBE" xlink:to="loc_us-gaap_DefinedBenefitPlanAccumulatedOtherComprehensiveIncomeNetPriorServiceCostCreditBeforeTax_D8C33E8748A9552A78B8F537498BC031" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DefinedBenefitPlanAmountsRecognizedInBalanceSheet" xlink:label="loc_us-gaap_DefinedBenefitPlanAmountsRecognizedInBalanceSheet_24BAA247203ED31DBF53F537498BA734" xlink:type="locator" />
    <presentationArc order="18" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_6DD46F153D74C3ABBD82F5374985CEBE" xlink:to="loc_us-gaap_DefinedBenefitPlanAmountsRecognizedInBalanceSheet_24BAA247203ED31DBF53F537498BA734" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.lilly.com/role/RetirementBenefitsScheduleOfComponentsInConsolidatedBalanceSheetsDetails" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansDisclosuresAbstract" xlink:label="loc_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansDisclosuresAbstract_262B0FCF980B27A87CB7FC036EEDC128" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansDisclosuresTable" xlink:label="loc_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansDisclosuresTable_5A85B3B9A601D73EFBB0FC036EED510A" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansDisclosuresAbstract_262B0FCF980B27A87CB7FC036EEDC128" xlink:to="loc_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansDisclosuresTable_5A85B3B9A601D73EFBB0FC036EED510A" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DefinedBenefitPlansDisclosuresDefinedBenefitPlansAxis" xlink:label="loc_us-gaap_DefinedBenefitPlansDisclosuresDefinedBenefitPlansAxis_6009C2206A1E38B1FEEDFC036EED540F" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansDisclosuresTable_5A85B3B9A601D73EFBB0FC036EED510A" xlink:to="loc_us-gaap_DefinedBenefitPlansDisclosuresDefinedBenefitPlansAxis_6009C2206A1E38B1FEEDFC036EED540F" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DefinedBenefitPlansDomain" xlink:label="loc_us-gaap_DefinedBenefitPlansDomain_C7422EC6105FA68904A0FC036EED14ED" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DefinedBenefitPlansDisclosuresDefinedBenefitPlansAxis_6009C2206A1E38B1FEEDFC036EED540F" xlink:to="loc_us-gaap_DefinedBenefitPlansDomain_C7422EC6105FA68904A0FC036EED14ED" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PensionPlansDefinedBenefitMember" xlink:label="loc_us-gaap_PensionPlansDefinedBenefitMember_91C06B98E21E5BEB1BDEFC036EEDDF74" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DefinedBenefitPlansDomain_C7422EC6105FA68904A0FC036EED14ED" xlink:to="loc_us-gaap_PensionPlansDefinedBenefitMember_91C06B98E21E5BEB1BDEFC036EEDDF74" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OtherPostretirementBenefitPlansDefinedBenefitMember" xlink:label="loc_us-gaap_OtherPostretirementBenefitPlansDefinedBenefitMember_A9068A8DFDCE33D1CF8BFC036EED0D47" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DefinedBenefitPlansDomain_C7422EC6105FA68904A0FC036EED14ED" xlink:to="loc_us-gaap_OtherPostretirementBenefitPlansDefinedBenefitMember_A9068A8DFDCE33D1CF8BFC036EED0D47" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_2F4537B4187347F8AA9AFC036EED025E" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansDisclosuresTable_5A85B3B9A601D73EFBB0FC036EED510A" xlink:to="loc_us-gaap_StatementLineItems_2F4537B4187347F8AA9AFC036EED025E" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DefinedBenefitPlanEffectOfPlanAmendmentOnAccumulatedBenefitObligation" xlink:label="loc_us-gaap_DefinedBenefitPlanEffectOfPlanAmendmentOnAccumulatedBenefitObligation_B204C531C5CA378E4E11FC036EEDF8D3" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_2F4537B4187347F8AA9AFC036EED025E" xlink:to="loc_us-gaap_DefinedBenefitPlanEffectOfPlanAmendmentOnAccumulatedBenefitObligation_B204C531C5CA378E4E11FC036EEDF8D3" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DefinedBenefitPlanFutureAmortizationOfGainLoss" xlink:label="loc_us-gaap_DefinedBenefitPlanFutureAmortizationOfGainLoss_2352DD2CFCF459D8B06FFC036EED40F5" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_2F4537B4187347F8AA9AFC036EED025E" xlink:to="loc_us-gaap_DefinedBenefitPlanFutureAmortizationOfGainLoss_2352DD2CFCF459D8B06FFC036EED40F5" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DefinedBenefitPlanAssetsForPlanBenefitsNoncurrent" xlink:label="loc_us-gaap_DefinedBenefitPlanAssetsForPlanBenefitsNoncurrent_2FB9AF99AA9CCD037B65FC036EEDF865" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_2F4537B4187347F8AA9AFC036EED025E" xlink:to="loc_us-gaap_DefinedBenefitPlanAssetsForPlanBenefitsNoncurrent_2FB9AF99AA9CCD037B65FC036EEDF865" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PensionAndOtherPostretirementDefinedBenefitPlansCurrentLiabilities" xlink:label="loc_us-gaap_PensionAndOtherPostretirementDefinedBenefitPlansCurrentLiabilities_F23615AF89A705569CB1FC036EEDF106" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_2F4537B4187347F8AA9AFC036EED025E" xlink:to="loc_us-gaap_PensionAndOtherPostretirementDefinedBenefitPlansCurrentLiabilities_F23615AF89A705569CB1FC036EEDF106" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PensionAndOtherPostretirementDefinedBenefitPlansLiabilitiesNoncurrent" xlink:label="loc_us-gaap_PensionAndOtherPostretirementDefinedBenefitPlansLiabilitiesNoncurrent_A1D1726396152C9CCACCFC036EED6384" xlink:type="locator" />
    <presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_2F4537B4187347F8AA9AFC036EED025E" xlink:to="loc_us-gaap_PensionAndOtherPostretirementDefinedBenefitPlansLiabilitiesNoncurrent_A1D1726396152C9CCACCFC036EED6384" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DefinedBenefitPlanAccumulatedOtherComprehensiveIncomeBeforeTax" xlink:label="loc_us-gaap_DefinedBenefitPlanAccumulatedOtherComprehensiveIncomeBeforeTax_0CA19DA92D8B5B07219EFC036EED08B2" xlink:type="locator" />
    <presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_2F4537B4187347F8AA9AFC036EED025E" xlink:to="loc_us-gaap_DefinedBenefitPlanAccumulatedOtherComprehensiveIncomeBeforeTax_0CA19DA92D8B5B07219EFC036EED08B2" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DefinedBenefitPlanAmountsRecognizedInBalanceSheet" xlink:label="loc_us-gaap_DefinedBenefitPlanAmountsRecognizedInBalanceSheet_493C684C5B6783A9F8A0FC036EF76C2B" xlink:type="locator" />
    <presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_2F4537B4187347F8AA9AFC036EED025E" xlink:to="loc_us-gaap_DefinedBenefitPlanAmountsRecognizedInBalanceSheet_493C684C5B6783A9F8A0FC036EF76C2B" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DefinedBenefitPlanAmountsRecognizedInOtherComprehensiveIncomeLossNetGainLossBeforeTax" xlink:label="loc_us-gaap_DefinedBenefitPlanAmountsRecognizedInOtherComprehensiveIncomeLossNetGainLossBeforeTax_DF6BA6AD772F5C8C0CC9FC036EF744E9" xlink:type="locator" />
    <presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_2F4537B4187347F8AA9AFC036EED025E" xlink:to="loc_us-gaap_DefinedBenefitPlanAmountsRecognizedInOtherComprehensiveIncomeLossNetGainLossBeforeTax_DF6BA6AD772F5C8C0CC9FC036EF744E9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossAmortizationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansForNetPriorServiceCostCreditBeforeTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossAmortizationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansForNetPriorServiceCostCreditBeforeTax_36E3686D94BAE5A42BE8FC036EF7BCCC" xlink:type="locator" />
    <presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_2F4537B4187347F8AA9AFC036EED025E" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossAmortizationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansForNetPriorServiceCostCreditBeforeTax_36E3686D94BAE5A42BE8FC036EF7BCCC" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.lilly.com/role/RetirementBenefitsScheduleOfExpectedBenefitPaymentsContributionsAndExpenseDetails" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansDisclosuresAbstract" xlink:label="loc_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansDisclosuresAbstract_4358DA0024DCFD52690BF5374938BFE9" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansDisclosuresTable" xlink:label="loc_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansDisclosuresTable_4F90BE03ACEDF27AB800F53749385FCF" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansDisclosuresAbstract_4358DA0024DCFD52690BF5374938BFE9" xlink:to="loc_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansDisclosuresTable_4F90BE03ACEDF27AB800F53749385FCF" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DefinedBenefitPlansDisclosuresDefinedBenefitPlansAxis" xlink:label="loc_us-gaap_DefinedBenefitPlansDisclosuresDefinedBenefitPlansAxis_18C1456C2E54312E9461F537493848A8" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansDisclosuresTable_4F90BE03ACEDF27AB800F53749385FCF" xlink:to="loc_us-gaap_DefinedBenefitPlansDisclosuresDefinedBenefitPlansAxis_18C1456C2E54312E9461F537493848A8" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DefinedBenefitPlansDomain" xlink:label="loc_us-gaap_DefinedBenefitPlansDomain_8C427D0777A1D141CA92F5374938E7AD" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DefinedBenefitPlansDisclosuresDefinedBenefitPlansAxis_18C1456C2E54312E9461F537493848A8" xlink:to="loc_us-gaap_DefinedBenefitPlansDomain_8C427D0777A1D141CA92F5374938E7AD" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PensionPlansDefinedBenefitMember" xlink:label="loc_us-gaap_PensionPlansDefinedBenefitMember_CE738AFF848C0A2D2BEBF5374938A37C" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DefinedBenefitPlansDomain_8C427D0777A1D141CA92F5374938E7AD" xlink:to="loc_us-gaap_PensionPlansDefinedBenefitMember_CE738AFF848C0A2D2BEBF5374938A37C" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OtherPostretirementBenefitPlansDefinedBenefitMember" xlink:label="loc_us-gaap_OtherPostretirementBenefitPlansDefinedBenefitMember_6A879CAB76AC897FBDF7F5374938260D" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DefinedBenefitPlansDomain_8C427D0777A1D141CA92F5374938E7AD" xlink:to="loc_us-gaap_OtherPostretirementBenefitPlansDefinedBenefitMember_6A879CAB76AC897FBDF7F5374938260D" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_4C1350409A37DB87E70EF5374938FBF5" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansDisclosuresTable_4F90BE03ACEDF27AB800F53749385FCF" xlink:to="loc_us-gaap_StatementLineItems_4C1350409A37DB87E70EF5374938FBF5" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_DefinedBenefitPlanEstimatedFutureEmployerContributionsinNextFiscalYearMinimum" xlink:label="loc_lly_DefinedBenefitPlanEstimatedFutureEmployerContributionsinNextFiscalYearMinimum_D3D2E525E18DD578711AF53749381C2E" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_4C1350409A37DB87E70EF5374938FBF5" xlink:to="loc_lly_DefinedBenefitPlanEstimatedFutureEmployerContributionsinNextFiscalYearMinimum_D3D2E525E18DD578711AF53749381C2E" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsNextTwelveMonths" xlink:label="loc_us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsNextTwelveMonths_4CD7061231C8156F0EA1F53749390F02" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_4C1350409A37DB87E70EF5374938FBF5" xlink:to="loc_us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsNextTwelveMonths_4CD7061231C8156F0EA1F53749390F02" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsYearTwo" xlink:label="loc_us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsYearTwo_584418065C33AFE33413F53749392146" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_4C1350409A37DB87E70EF5374938FBF5" xlink:to="loc_us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsYearTwo_584418065C33AFE33413F53749392146" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsYearThree" xlink:label="loc_us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsYearThree_2C60ED6F9AD4A8056B3EF537493955AD" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_4C1350409A37DB87E70EF5374938FBF5" xlink:to="loc_us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsYearThree_2C60ED6F9AD4A8056B3EF537493955AD" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsYearFour" xlink:label="loc_us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsYearFour_C99436181A09C0804C2EF537493991CF" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_4C1350409A37DB87E70EF5374938FBF5" xlink:to="loc_us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsYearFour_C99436181A09C0804C2EF537493991CF" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsYearFive" xlink:label="loc_us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsYearFive_0D01C097C9B1519F53C0F53749391DA0" xlink:type="locator" />
    <presentationArc order="6" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_4C1350409A37DB87E70EF5374938FBF5" xlink:to="loc_us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsYearFive_0D01C097C9B1519F53C0F53749391DA0" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsFiveFiscalYearsThereafter" xlink:label="loc_us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsFiveFiscalYearsThereafter_6E8A1251B46F38BD763DF53749390A92" xlink:type="locator" />
    <presentationArc order="7" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_4C1350409A37DB87E70EF5374938FBF5" xlink:to="loc_us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsFiveFiscalYearsThereafter_6E8A1251B46F38BD763DF53749390A92" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DefinedBenefitPlanAccumulatedBenefitObligation" xlink:label="loc_us-gaap_DefinedBenefitPlanAccumulatedBenefitObligation_6F9490C5F0466FCB9579F53749390D51" xlink:type="locator" />
    <presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_4C1350409A37DB87E70EF5374938FBF5" xlink:to="loc_us-gaap_DefinedBenefitPlanAccumulatedBenefitObligation_6F9490C5F0466FCB9579F53749390D51" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DefinedBenefitPlanPlansWithBenefitObligationsInExcessOfPlanAssetsAggregateBenefitObligation" xlink:label="loc_us-gaap_DefinedBenefitPlanPlansWithBenefitObligationsInExcessOfPlanAssetsAggregateBenefitObligation_84BF163A7A692C29391BF5374939EFB5" xlink:type="locator" />
    <presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_4C1350409A37DB87E70EF5374938FBF5" xlink:to="loc_us-gaap_DefinedBenefitPlanPlansWithBenefitObligationsInExcessOfPlanAssetsAggregateBenefitObligation_84BF163A7A692C29391BF5374939EFB5" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DefinedBenefitPlanPlansWithBenefitObligationsInExcessOfPlanAssetsAggregateFairValueOfPlanAssets" xlink:label="loc_us-gaap_DefinedBenefitPlanPlansWithBenefitObligationsInExcessOfPlanAssetsAggregateFairValueOfPlanAssets_6C5A6055A79898CF3B30F5374939ECFE" xlink:type="locator" />
    <presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_4C1350409A37DB87E70EF5374938FBF5" xlink:to="loc_us-gaap_DefinedBenefitPlanPlansWithBenefitObligationsInExcessOfPlanAssetsAggregateFairValueOfPlanAssets_6C5A6055A79898CF3B30F5374939ECFE" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DefinedBenefitPlanPensionPlansWithAccumulatedBenefitObligationsInExcessOfPlanAssetsAggregateAccumulatedBenefitObligation" xlink:label="loc_us-gaap_DefinedBenefitPlanPensionPlansWithAccumulatedBenefitObligationsInExcessOfPlanAssetsAggregateAccumulatedBenefitObligation_21A528D027C0DBD3CF1EF5374939BC19" xlink:type="locator" />
    <presentationArc order="11" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_4C1350409A37DB87E70EF5374938FBF5" xlink:to="loc_us-gaap_DefinedBenefitPlanPensionPlansWithAccumulatedBenefitObligationsInExcessOfPlanAssetsAggregateAccumulatedBenefitObligation_21A528D027C0DBD3CF1EF5374939BC19" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DefinedBenefitPlanPensionPlansWithAccumulatedBenefitObligationsInExcessOfPlanAssetsAggregateFairValueOfPlanAssets" xlink:label="loc_us-gaap_DefinedBenefitPlanPensionPlansWithAccumulatedBenefitObligationsInExcessOfPlanAssetsAggregateFairValueOfPlanAssets_85CDC56A3BB51637FB07F5374939A74F" xlink:type="locator" />
    <presentationArc order="12" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_4C1350409A37DB87E70EF5374938FBF5" xlink:to="loc_us-gaap_DefinedBenefitPlanPensionPlansWithAccumulatedBenefitObligationsInExcessOfPlanAssetsAggregateFairValueOfPlanAssets_85CDC56A3BB51637FB07F5374939A74F" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DefinedBenefitPlanServiceCost" xlink:label="loc_us-gaap_DefinedBenefitPlanServiceCost_BDDE10BFDF0997C758F0F5374939794B" xlink:type="locator" />
    <presentationArc order="13" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_4C1350409A37DB87E70EF5374938FBF5" xlink:to="loc_us-gaap_DefinedBenefitPlanServiceCost_BDDE10BFDF0997C758F0F5374939794B" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DefinedBenefitPlanInterestCost" xlink:label="loc_us-gaap_DefinedBenefitPlanInterestCost_890F7186913386EE5674F5374939EF55" xlink:type="locator" />
    <presentationArc order="14" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_4C1350409A37DB87E70EF5374938FBF5" xlink:to="loc_us-gaap_DefinedBenefitPlanInterestCost_890F7186913386EE5674F5374939EF55" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DefinedBenefitPlanExpectedReturnOnPlanAssets" xlink:label="loc_us-gaap_DefinedBenefitPlanExpectedReturnOnPlanAssets_20B36EF1319C9BC8DE3BF53749390A0B" xlink:type="locator" />
    <presentationArc order="15" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_4C1350409A37DB87E70EF5374938FBF5" xlink:to="loc_us-gaap_DefinedBenefitPlanExpectedReturnOnPlanAssets_20B36EF1319C9BC8DE3BF53749390A0B" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DefinedBenefitPlanAmortizationOfPriorServiceCostCredit" xlink:label="loc_us-gaap_DefinedBenefitPlanAmortizationOfPriorServiceCostCredit_3F461A76323DFB21D142F5374939BCAB" xlink:type="locator" />
    <presentationArc order="16" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_4C1350409A37DB87E70EF5374938FBF5" xlink:to="loc_us-gaap_DefinedBenefitPlanAmortizationOfPriorServiceCostCredit_3F461A76323DFB21D142F5374939BCAB" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DefinedBenefitPlanAmortizationOfGainsLosses" xlink:label="loc_us-gaap_DefinedBenefitPlanAmortizationOfGainsLosses_DE8926651A4BCFDEEF3CF53749398FB8" xlink:type="locator" />
    <presentationArc order="17" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_4C1350409A37DB87E70EF5374938FBF5" xlink:to="loc_us-gaap_DefinedBenefitPlanAmortizationOfGainsLosses_DE8926651A4BCFDEEF3CF53749398FB8" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DefinedBenefitPlanFutureAmortizationOfGainLoss" xlink:label="loc_us-gaap_DefinedBenefitPlanFutureAmortizationOfGainLoss_19441858D950E9C12768F53749391EA0" xlink:type="locator" />
    <presentationArc order="18" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_4C1350409A37DB87E70EF5374938FBF5" xlink:to="loc_us-gaap_DefinedBenefitPlanFutureAmortizationOfGainLoss_19441858D950E9C12768F53749391EA0" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DefinedBenefitPlanFutureAmortizationOfPriorServiceCostCredit" xlink:label="loc_us-gaap_DefinedBenefitPlanFutureAmortizationOfPriorServiceCostCredit_836450C86F2883A351B4F5374939A92F" xlink:type="locator" />
    <presentationArc order="19" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_4C1350409A37DB87E70EF5374938FBF5" xlink:to="loc_us-gaap_DefinedBenefitPlanFutureAmortizationOfPriorServiceCostCredit_836450C86F2883A351B4F5374939A92F" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost" xlink:label="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost_FAD91EFB812C7D005A4AF537493AAEC5" xlink:type="locator" />
    <presentationArc order="20" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_4C1350409A37DB87E70EF5374938FBF5" xlink:to="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost_FAD91EFB812C7D005A4AF537493AAEC5" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansNetUnamortizedGainLossArisingDuringPeriodBeforeTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansNetUnamortizedGainLossArisingDuringPeriodBeforeTax_94DEE86CFBFCEDDB32FFF537493ABF81" xlink:type="locator" />
    <presentationArc order="21" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_4C1350409A37DB87E70EF5374938FBF5" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansNetUnamortizedGainLossArisingDuringPeriodBeforeTax_94DEE86CFBFCEDDB32FFF537493ABF81" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OtherComprehensiveIncomeDefinedBenefitPlanNetPriorServiceCostCreditArisingDuringPeriodBeforeTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeDefinedBenefitPlanNetPriorServiceCostCreditArisingDuringPeriodBeforeTax_A69B71957901CA4607E5F537493A1D62" xlink:type="locator" />
    <presentationArc order="22" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_4C1350409A37DB87E70EF5374938FBF5" xlink:to="loc_us-gaap_OtherComprehensiveIncomeDefinedBenefitPlanNetPriorServiceCostCreditArisingDuringPeriodBeforeTax_A69B71957901CA4607E5F537493A1D62" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossAmortizationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansForNetPriorServiceCostCreditBeforeTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossAmortizationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansForNetPriorServiceCostCreditBeforeTax_84D3B5EF628DDFFBDF8CF537493A6087" xlink:type="locator" />
    <presentationArc order="23" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_4C1350409A37DB87E70EF5374938FBF5" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossAmortizationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansForNetPriorServiceCostCreditBeforeTax_84D3B5EF628DDFFBDF8CF537493A6087" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DefinedBenefitPlanAmountsRecognizedInOtherComprehensiveIncomeLossNetGainLossBeforeTax" xlink:label="loc_us-gaap_DefinedBenefitPlanAmountsRecognizedInOtherComprehensiveIncomeLossNetGainLossBeforeTax_53217BA498BA9C75F25AF537493F375B" xlink:type="locator" />
    <presentationArc order="24" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_4C1350409A37DB87E70EF5374938FBF5" xlink:to="loc_us-gaap_DefinedBenefitPlanAmountsRecognizedInOtherComprehensiveIncomeLossNetGainLossBeforeTax_53217BA498BA9C75F25AF537493F375B" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DefinedBenefitPlanAmountToBeAmortizedFromAccumulatedOtherComprehensiveIncomeLossNextFiscalYear" xlink:label="loc_us-gaap_DefinedBenefitPlanAmountToBeAmortizedFromAccumulatedOtherComprehensiveIncomeLossNextFiscalYear_C83CB9ED0FF6479B1328F537493F9DF8" xlink:type="locator" />
    <presentationArc order="25" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_4C1350409A37DB87E70EF5374938FBF5" xlink:to="loc_us-gaap_DefinedBenefitPlanAmountToBeAmortizedFromAccumulatedOtherComprehensiveIncomeLossNextFiscalYear_C83CB9ED0FF6479B1328F537493F9DF8" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentBeforeTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentBeforeTax_ED5C4190D452902B0FADF537493FFF52" xlink:type="locator" />
    <presentationArc order="26" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_4C1350409A37DB87E70EF5374938FBF5" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentBeforeTax_ED5C4190D452902B0FADF537493FFF52" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansAdjustmentBeforeTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansAdjustmentBeforeTax_543497B915E981D1C974F537493F5DC0" xlink:type="locator" />
    <presentationArc order="27" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_4C1350409A37DB87E70EF5374938FBF5" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansAdjustmentBeforeTax_543497B915E981D1C974F537493F5DC0" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DefinedContributionPlanCostRecognized" xlink:label="loc_us-gaap_DefinedContributionPlanCostRecognized_4C415527A96172816CBCF537493FBA85" xlink:type="locator" />
    <presentationArc order="28" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_4C1350409A37DB87E70EF5374938FBF5" xlink:to="loc_us-gaap_DefinedContributionPlanCostRecognized_4C415527A96172816CBCF537493FBA85" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_DefinedBenefitPlanEstimatedFutureEmployerContributionsinNextFiscalYearDiscretionary" xlink:label="loc_lly_DefinedBenefitPlanEstimatedFutureEmployerContributionsinNextFiscalYearDiscretionary_FA6EDB86794CE32D7D1DF53749406CEC" xlink:type="locator" />
    <presentationArc order="29" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_4C1350409A37DB87E70EF5374938FBF5" xlink:to="loc_lly_DefinedBenefitPlanEstimatedFutureEmployerContributionsinNextFiscalYearDiscretionary_FA6EDB86794CE32D7D1DF53749406CEC" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.lilly.com/role/RetirementBenefitsScheduleOfWeightedAverageAssumptionsDetails" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansDisclosuresAbstract" xlink:label="loc_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansDisclosuresAbstract_760159EFB906614F3959F537494F7681" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansDisclosuresTable" xlink:label="loc_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansDisclosuresTable_D2ADFD378A533AC679F7F537494FC2A2" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansDisclosuresAbstract_760159EFB906614F3959F537494F7681" xlink:to="loc_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansDisclosuresTable_D2ADFD378A533AC679F7F537494FC2A2" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DefinedBenefitPlansDisclosuresDefinedBenefitPlansAxis" xlink:label="loc_us-gaap_DefinedBenefitPlansDisclosuresDefinedBenefitPlansAxis_F30982412616717B7D6AF537494F236F" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansDisclosuresTable_D2ADFD378A533AC679F7F537494FC2A2" xlink:to="loc_us-gaap_DefinedBenefitPlansDisclosuresDefinedBenefitPlansAxis_F30982412616717B7D6AF537494F236F" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DefinedBenefitPlansDomain" xlink:label="loc_us-gaap_DefinedBenefitPlansDomain_5FD27124AC9488C816E4F537494FB3C1" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DefinedBenefitPlansDisclosuresDefinedBenefitPlansAxis_F30982412616717B7D6AF537494F236F" xlink:to="loc_us-gaap_DefinedBenefitPlansDomain_5FD27124AC9488C816E4F537494FB3C1" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PensionPlansDefinedBenefitMember" xlink:label="loc_us-gaap_PensionPlansDefinedBenefitMember_63FD000960C0F5A807ADF537494FC7D8" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DefinedBenefitPlansDomain_5FD27124AC9488C816E4F537494FB3C1" xlink:to="loc_us-gaap_PensionPlansDefinedBenefitMember_63FD000960C0F5A807ADF537494FC7D8" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OtherPostretirementBenefitPlansDefinedBenefitMember" xlink:label="loc_us-gaap_OtherPostretirementBenefitPlansDefinedBenefitMember_B46720843F392E98A084F537494FD4C3" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DefinedBenefitPlansDomain_5FD27124AC9488C816E4F537494FB3C1" xlink:to="loc_us-gaap_OtherPostretirementBenefitPlansDefinedBenefitMember_B46720843F392E98A084F537494FD4C3" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_1311D42DE3A56017921DF537494F6AF1" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansDisclosuresTable_D2ADFD378A533AC679F7F537494FC2A2" xlink:to="loc_us-gaap_StatementLineItems_1311D42DE3A56017921DF537494F6AF1" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DefinedBenefitPlanAssumptionsUsedCalculatingBenefitObligationDiscountRate" xlink:label="loc_us-gaap_DefinedBenefitPlanAssumptionsUsedCalculatingBenefitObligationDiscountRate_4B83E912FC86D1D26D62F537494FCDDA" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_1311D42DE3A56017921DF537494F6AF1" xlink:to="loc_us-gaap_DefinedBenefitPlanAssumptionsUsedCalculatingBenefitObligationDiscountRate_4B83E912FC86D1D26D62F537494FCDDA" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DefinedBenefitPlanAssumptionsUsedCalculatingNetPeriodicBenefitCostDiscountRate" xlink:label="loc_us-gaap_DefinedBenefitPlanAssumptionsUsedCalculatingNetPeriodicBenefitCostDiscountRate_A3520F0E7223B44D8D88F537495007B4" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_1311D42DE3A56017921DF537494F6AF1" xlink:to="loc_us-gaap_DefinedBenefitPlanAssumptionsUsedCalculatingNetPeriodicBenefitCostDiscountRate_A3520F0E7223B44D8D88F537495007B4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DefinedBenefitPlanAssumptionsUsedCalculatingBenefitObligationRateOfCompensationIncrease" xlink:label="loc_us-gaap_DefinedBenefitPlanAssumptionsUsedCalculatingBenefitObligationRateOfCompensationIncrease_528AD0166CE674B3DBBEF5374950ED8D" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_1311D42DE3A56017921DF537494F6AF1" xlink:to="loc_us-gaap_DefinedBenefitPlanAssumptionsUsedCalculatingBenefitObligationRateOfCompensationIncrease_528AD0166CE674B3DBBEF5374950ED8D" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DefinedBenefitPlanAssumptionsUsedCalculatingNetPeriodicBenefitCostRateOfCompensationIncrease" xlink:label="loc_us-gaap_DefinedBenefitPlanAssumptionsUsedCalculatingNetPeriodicBenefitCostRateOfCompensationIncrease_39790C1B022AD77FD1B0F53749507D28" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_1311D42DE3A56017921DF537494F6AF1" xlink:to="loc_us-gaap_DefinedBenefitPlanAssumptionsUsedCalculatingNetPeriodicBenefitCostRateOfCompensationIncrease_39790C1B022AD77FD1B0F53749507D28" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DefinedBenefitPlanAssumptionsUsedCalculatingNetPeriodicBenefitCostExpectedLongTermReturnOnAssets" xlink:label="loc_us-gaap_DefinedBenefitPlanAssumptionsUsedCalculatingNetPeriodicBenefitCostExpectedLongTermReturnOnAssets_30F4B9F55F64E64D3363F53749505F42" xlink:type="locator" />
    <presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_1311D42DE3A56017921DF537494F6AF1" xlink:to="loc_us-gaap_DefinedBenefitPlanAssumptionsUsedCalculatingNetPeriodicBenefitCostExpectedLongTermReturnOnAssets_30F4B9F55F64E64D3363F53749505F42" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_DefinedBenefitPlanDirectionAndPatternForAssumedHealthCareCostTrendRate" xlink:label="loc_lly_DefinedBenefitPlanDirectionAndPatternForAssumedHealthCareCostTrendRate_FF65CE222D7548459111F53749500E27" xlink:type="locator" />
    <presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_1311D42DE3A56017921DF537494F6AF1" xlink:to="loc_lly_DefinedBenefitPlanDirectionAndPatternForAssumedHealthCareCostTrendRate_FF65CE222D7548459111F53749500E27" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.lilly.com/role/RetirementBenefitsTables" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansDisclosuresAbstract" xlink:label="loc_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansDisclosuresAbstract_621C131C9DC51C17B506FC037019D62B" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansDisclosuresTable" xlink:label="loc_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansDisclosuresTable_0865D2381ADF293B7A33FC03701990D3" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansDisclosuresAbstract_621C131C9DC51C17B506FC037019D62B" xlink:to="loc_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansDisclosuresTable_0865D2381ADF293B7A33FC03701990D3" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DefinedBenefitPlansDisclosuresDefinedBenefitPlansAxis" xlink:label="loc_us-gaap_DefinedBenefitPlansDisclosuresDefinedBenefitPlansAxis_336B0529A446502CA02AFC037019E572" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansDisclosuresTable_0865D2381ADF293B7A33FC03701990D3" xlink:to="loc_us-gaap_DefinedBenefitPlansDisclosuresDefinedBenefitPlansAxis_336B0529A446502CA02AFC037019E572" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DefinedBenefitPlansDomain" xlink:label="loc_us-gaap_DefinedBenefitPlansDomain_E1C8660E0892E6FA598EFC0370198825" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DefinedBenefitPlansDisclosuresDefinedBenefitPlansAxis_336B0529A446502CA02AFC037019E572" xlink:to="loc_us-gaap_DefinedBenefitPlansDomain_E1C8660E0892E6FA598EFC0370198825" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PensionPlansDefinedBenefitMember" xlink:label="loc_us-gaap_PensionPlansDefinedBenefitMember_0B91B3286B1A2FA4C6D7FC037019DC69" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DefinedBenefitPlansDomain_E1C8660E0892E6FA598EFC0370198825" xlink:to="loc_us-gaap_PensionPlansDefinedBenefitMember_0B91B3286B1A2FA4C6D7FC037019DC69" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_99924769C640EB5D93C1FC03701901BB" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansDisclosuresTable_0865D2381ADF293B7A33FC03701990D3" xlink:to="loc_us-gaap_StatementLineItems_99924769C640EB5D93C1FC03701901BB" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScheduleOfChangesInAccumulatedPostemploymentBenefitObligationsTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfChangesInAccumulatedPostemploymentBenefitObligationsTableTextBlock_668589C1AEB9B94235CDFC0370192CAD" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_99924769C640EB5D93C1FC03701901BB" xlink:to="loc_us-gaap_ScheduleOfChangesInAccumulatedPostemploymentBenefitObligationsTableTextBlock_668589C1AEB9B94235CDFC0370192CAD" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScheduleOfChangesInFairValueOfPlanAssetsTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfChangesInFairValueOfPlanAssetsTableTextBlock_A33234FFC5322E595EC3FC037019D7DF" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_99924769C640EB5D93C1FC03701901BB" xlink:to="loc_us-gaap_ScheduleOfChangesInFairValueOfPlanAssetsTableTextBlock_A33234FFC5322E595EC3FC037019D7DF" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScheduleOfNetFundedStatusTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfNetFundedStatusTableTextBlock_3F22D95031E8CBCDBA43FC037019AC39" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_99924769C640EB5D93C1FC03701901BB" xlink:to="loc_us-gaap_ScheduleOfNetFundedStatusTableTextBlock_3F22D95031E8CBCDBA43FC037019AC39" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScheduleOfAmountsRecognizedInBalanceSheetTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfAmountsRecognizedInBalanceSheetTableTextBlock_939ED65989A68C4CFB72FC037019A73D" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_99924769C640EB5D93C1FC03701901BB" xlink:to="loc_us-gaap_ScheduleOfAmountsRecognizedInBalanceSheetTableTextBlock_939ED65989A68C4CFB72FC037019A73D" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScheduleOfAmountsInAccumulatedOtherComprehensiveIncomeLossToBeRecognizedOverNextFiscalYearTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfAmountsInAccumulatedOtherComprehensiveIncomeLossToBeRecognizedOverNextFiscalYearTableTextBlock_C23106950E4F45C83154FC037019B2C5" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_99924769C640EB5D93C1FC03701901BB" xlink:to="loc_us-gaap_ScheduleOfAmountsInAccumulatedOtherComprehensiveIncomeLossToBeRecognizedOverNextFiscalYearTableTextBlock_C23106950E4F45C83154FC037019B2C5" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScheduleOfAssumptionsUsedTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfAssumptionsUsedTableTextBlock_A93AE3676C893F15C7ACFC0370192972" xlink:type="locator" />
    <presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_99924769C640EB5D93C1FC03701901BB" xlink:to="loc_us-gaap_ScheduleOfAssumptionsUsedTableTextBlock_A93AE3676C893F15C7ACFC0370192972" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScheduleOfExpectedBenefitPaymentsTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfExpectedBenefitPaymentsTableTextBlock_EA0D2C335BCE3F50A094FC037019B980" xlink:type="locator" />
    <presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_99924769C640EB5D93C1FC03701901BB" xlink:to="loc_us-gaap_ScheduleOfExpectedBenefitPaymentsTableTextBlock_EA0D2C335BCE3F50A094FC037019B980" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScheduleOfNetBenefitCostsTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfNetBenefitCostsTableTextBlock_2BB0F1D6DD98446D5339FC0370196D07" xlink:type="locator" />
    <presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_99924769C640EB5D93C1FC03701901BB" xlink:to="loc_us-gaap_ScheduleOfNetBenefitCostsTableTextBlock_2BB0F1D6DD98446D5339FC0370196D07" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScheduleOfAmountsRecognizedInOtherComprehensiveIncomeLossTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfAmountsRecognizedInOtherComprehensiveIncomeLossTableTextBlock_AC3B3F739AF8CFED8836FC0370192812" xlink:type="locator" />
    <presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_99924769C640EB5D93C1FC03701901BB" xlink:to="loc_us-gaap_ScheduleOfAmountsRecognizedInOtherComprehensiveIncomeLossTableTextBlock_AC3B3F739AF8CFED8836FC0370192812" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScheduleOfAllocationOfPlanAssetsTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfAllocationOfPlanAssetsTableTextBlock_D52333687E2753AF0C81FC037019FA6C" xlink:type="locator" />
    <presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_99924769C640EB5D93C1FC03701901BB" xlink:to="loc_us-gaap_ScheduleOfAllocationOfPlanAssetsTableTextBlock_D52333687E2753AF0C81FC037019FA6C" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationTextBlock" xlink:label="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationTextBlock_EE33E976CD10EB778358FC037019C8C5" xlink:type="locator" />
    <presentationArc order="11" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_99924769C640EB5D93C1FC03701901BB" xlink:to="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationTextBlock_EE33E976CD10EB778358FC037019C8C5" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScheduleOfBenefitObligationsInExcessOfFairValueOfPlanAssetsTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfBenefitObligationsInExcessOfFairValueOfPlanAssetsTableTextBlock_A898F564533D964E7499FC037019133D" xlink:type="locator" />
    <presentationArc order="12" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_99924769C640EB5D93C1FC03701901BB" xlink:to="loc_us-gaap_ScheduleOfBenefitObligationsInExcessOfFairValueOfPlanAssetsTableTextBlock_A898F564533D964E7499FC037019133D" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScheduleOfAccumulatedBenefitObligationsInExcessOfFairValueOfPlanAssetsTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfAccumulatedBenefitObligationsInExcessOfFairValueOfPlanAssetsTableTextBlock_DA79C6C45659F262CC00FC037019F93A" xlink:type="locator" />
    <presentationArc order="13" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_99924769C640EB5D93C1FC03701901BB" xlink:to="loc_us-gaap_ScheduleOfAccumulatedBenefitObligationsInExcessOfFairValueOfPlanAssetsTableTextBlock_DA79C6C45659F262CC00FC037019F93A" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.lilly.com/role/SegmentInformation" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_SegmentReportingAbstract" xlink:label="loc_us-gaap_SegmentReportingAbstract_1CB2810698DBC7D252DBEA82F96C1E31" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_SegmentReportingDisclosureTextBlock" xlink:label="loc_us-gaap_SegmentReportingDisclosureTextBlock_0D81A6E6EFA5120C5746EA82F96C5C0E" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentReportingAbstract_1CB2810698DBC7D252DBEA82F96C1E31" xlink:to="loc_us-gaap_SegmentReportingDisclosureTextBlock_0D81A6E6EFA5120C5746EA82F96C5C0E" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.lilly.com/role/SegmentInformationSegmentInformationDetails" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_SegmentReportingAbstract" xlink:label="loc_us-gaap_SegmentReportingAbstract_503FB1109330EE293182F515710296DF" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable" xlink:label="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_A4FEFB48786E53785842F51571028CD1" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentReportingAbstract_503FB1109330EE293182F515710296DF" xlink:to="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_A4FEFB48786E53785842F51571028CD1" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ExtinguishmentOfDebtAxis" xlink:label="loc_us-gaap_ExtinguishmentOfDebtAxis_415834135C1DDCF67479F5157102954D" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_A4FEFB48786E53785842F51571028CD1" xlink:to="loc_us-gaap_ExtinguishmentOfDebtAxis_415834135C1DDCF67479F5157102954D" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ExtinguishmentOfDebtTypeDomain" xlink:label="loc_us-gaap_ExtinguishmentOfDebtTypeDomain_26A99BCC95A200128102F5157102D8BD" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ExtinguishmentOfDebtAxis_415834135C1DDCF67479F5157102954D" xlink:to="loc_us-gaap_ExtinguishmentOfDebtTypeDomain_26A99BCC95A200128102F5157102D8BD" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_LongTermDebtMember" xlink:label="loc_us-gaap_LongTermDebtMember_F49744B54F4A4E23B37CF5157102EA68" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ExtinguishmentOfDebtTypeDomain_26A99BCC95A200128102F5157102D8BD" xlink:to="loc_us-gaap_LongTermDebtMember_F49744B54F4A4E23B37CF5157102EA68" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_NonrecurringAdjustmentAxis" xlink:label="loc_us-gaap_NonrecurringAdjustmentAxis_66B1BF4982A234B6F3CFF51571028061" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_A4FEFB48786E53785842F51571028CD1" xlink:to="loc_us-gaap_NonrecurringAdjustmentAxis_66B1BF4982A234B6F3CFF51571028061" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_NonrecurringAdjustmentDomain" xlink:label="loc_us-gaap_NonrecurringAdjustmentDomain_D23426098DB2D45FF5D1F51571027D30" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NonrecurringAdjustmentAxis_66B1BF4982A234B6F3CFF51571028061" xlink:to="loc_us-gaap_NonrecurringAdjustmentDomain_D23426098DB2D45FF5D1F51571027D30" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FairValueAdjustmentToInventoryMember" xlink:label="loc_us-gaap_FairValueAdjustmentToInventoryMember_F1467517551C7834A925F5157102FE05" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NonrecurringAdjustmentDomain_D23426098DB2D45FF5D1F51571027D30" xlink:to="loc_us-gaap_FairValueAdjustmentToInventoryMember_F1467517551C7834A925F5157102FE05" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_RangeAxis" xlink:label="loc_us-gaap_RangeAxis_8EFC2EC2D0EFB29FBE5AF5157102CE2A" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_A4FEFB48786E53785842F51571028CD1" xlink:to="loc_us-gaap_RangeAxis_8EFC2EC2D0EFB29FBE5AF5157102CE2A" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_RangeMember" xlink:label="loc_us-gaap_RangeMember_2B8B1340831E58AA56E2F51571029257" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RangeAxis_8EFC2EC2D0EFB29FBE5AF5157102CE2A" xlink:to="loc_us-gaap_RangeMember_2B8B1340831E58AA56E2F51571029257" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_MinimumMember" xlink:label="loc_us-gaap_MinimumMember_B4F282952CD2E06AFFC0F5157102E6C3" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RangeMember_2B8B1340831E58AA56E2F51571029257" xlink:to="loc_us-gaap_MinimumMember_B4F282952CD2E06AFFC0F5157102E6C3" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_MaximumMember" xlink:label="loc_us-gaap_MaximumMember_22210CF7BB13736FD976F5157102A558" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RangeMember_2B8B1340831E58AA56E2F51571029257" xlink:to="loc_us-gaap_MaximumMember_22210CF7BB13736FD976F5157102A558" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ProductOrServiceAxis" xlink:label="loc_us-gaap_ProductOrServiceAxis_BDC79EDFC9CF3B994D96F51571020472" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_A4FEFB48786E53785842F51571028CD1" xlink:to="loc_us-gaap_ProductOrServiceAxis_BDC79EDFC9CF3B994D96F51571020472" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ProductsAndServicesDomain" xlink:label="loc_us-gaap_ProductsAndServicesDomain_064B60263C2B188A9A08F51571029B66" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ProductOrServiceAxis_BDC79EDFC9CF3B994D96F51571020472" xlink:to="loc_us-gaap_ProductsAndServicesDomain_064B60263C2B188A9A08F51571029B66" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_AmylinMember" xlink:label="loc_lly_AmylinMember_382B36EED94A05A488C5F5157102018B" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ProductsAndServicesDomain_064B60263C2B188A9A08F51571029B66" xlink:to="loc_lly_AmylinMember_382B36EED94A05A488C5F5157102018B" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_CymbaltaMember" xlink:label="loc_lly_CymbaltaMember_22616664D9B9B562E766F51571024F90" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ProductsAndServicesDomain_064B60263C2B188A9A08F51571029B66" xlink:to="loc_lly_CymbaltaMember_22616664D9B9B562E766F51571024F90" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_HumalogMember" xlink:label="loc_lly_HumalogMember_2F8C69262F7F51006671F51571023987" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ProductsAndServicesDomain_064B60263C2B188A9A08F51571029B66" xlink:to="loc_lly_HumalogMember_2F8C69262F7F51006671F51571023987" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_HumulinMember" xlink:label="loc_lly_HumulinMember_B852560E47D608554091F5157102C8FC" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ProductsAndServicesDomain_064B60263C2B188A9A08F51571029B66" xlink:to="loc_lly_HumulinMember_B852560E47D608554091F5157102C8FC" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_ForteoMember" xlink:label="loc_lly_ForteoMember_3B874E71563FDBE47F3EF51571026AC7" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ProductsAndServicesDomain_064B60263C2B188A9A08F51571029B66" xlink:to="loc_lly_ForteoMember_3B874E71563FDBE47F3EF51571026AC7" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_EvistaMember" xlink:label="loc_lly_EvistaMember_F0A29EF7A33B4EAEEB94F51571029257" xlink:type="locator" />
    <presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ProductsAndServicesDomain_064B60263C2B188A9A08F51571029B66" xlink:to="loc_lly_EvistaMember_F0A29EF7A33B4EAEEB94F51571029257" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_TrajentaBIMember" xlink:label="loc_lly_TrajentaBIMember_D3BC36EA395683F6243BF5157102F341" xlink:type="locator" />
    <presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ProductsAndServicesDomain_064B60263C2B188A9A08F51571029B66" xlink:to="loc_lly_TrajentaBIMember_D3BC36EA395683F6243BF5157102F341" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_TrulicityMemberMember" xlink:label="loc_lly_TrulicityMemberMember_316239B7F4ADF64253B0F5157102E6A3" xlink:type="locator" />
    <presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ProductsAndServicesDomain_064B60263C2B188A9A08F51571029B66" xlink:to="loc_lly_TrulicityMemberMember_316239B7F4ADF64253B0F5157102E6A3" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_OtherEndocrinologyMember" xlink:label="loc_lly_OtherEndocrinologyMember_F63E8DE3D542D846DE03F51571029D6E" xlink:type="locator" />
    <presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ProductsAndServicesDomain_064B60263C2B188A9A08F51571029B66" xlink:to="loc_lly_OtherEndocrinologyMember_F63E8DE3D542D846DE03F51571029D6E" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_ZyprexaMember" xlink:label="loc_lly_ZyprexaMember_884D77116AE563400D06F5157102722C" xlink:type="locator" />
    <presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ProductsAndServicesDomain_064B60263C2B188A9A08F51571029B66" xlink:to="loc_lly_ZyprexaMember_884D77116AE563400D06F5157102722C" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_StratteraMember" xlink:label="loc_lly_StratteraMember_0B3AD4CAD01A3CB11D04F5157102C33E" xlink:type="locator" />
    <presentationArc order="11" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ProductsAndServicesDomain_064B60263C2B188A9A08F51571029B66" xlink:to="loc_lly_StratteraMember_0B3AD4CAD01A3CB11D04F5157102C33E" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_OtherNeuroscienceMember" xlink:label="loc_lly_OtherNeuroscienceMember_2D13EE9B7982C6B3AAB6F5157102AEE8" xlink:type="locator" />
    <presentationArc order="12" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ProductsAndServicesDomain_064B60263C2B188A9A08F51571029B66" xlink:to="loc_lly_OtherNeuroscienceMember_2D13EE9B7982C6B3AAB6F5157102AEE8" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_AlimtaMember" xlink:label="loc_lly_AlimtaMember_2A1F28FBE21061755A1EF51571026A62" xlink:type="locator" />
    <presentationArc order="13" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ProductsAndServicesDomain_064B60263C2B188A9A08F51571029B66" xlink:to="loc_lly_AlimtaMember_2A1F28FBE21061755A1EF51571026A62" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_ErbituxMember" xlink:label="loc_lly_ErbituxMember_9EA196D9672CE5D6D895F51571027C24" xlink:type="locator" />
    <presentationArc order="14" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ProductsAndServicesDomain_064B60263C2B188A9A08F51571029B66" xlink:to="loc_lly_ErbituxMember_9EA196D9672CE5D6D895F51571027C24" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_CyramzaMemberDomain" xlink:label="loc_lly_CyramzaMemberDomain_27EE89682ACD2C064391F51571029705" xlink:type="locator" />
    <presentationArc order="15" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ProductsAndServicesDomain_064B60263C2B188A9A08F51571029B66" xlink:to="loc_lly_CyramzaMemberDomain_27EE89682ACD2C064391F51571029705" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_OtherOncologyMember" xlink:label="loc_lly_OtherOncologyMember_6D0E3B89ADB12D291D38F5157102C97F" xlink:type="locator" />
    <presentationArc order="16" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ProductsAndServicesDomain_064B60263C2B188A9A08F51571029B66" xlink:to="loc_lly_OtherOncologyMember_6D0E3B89ADB12D291D38F5157102C97F" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_CialisMember" xlink:label="loc_lly_CialisMember_EE5256A0DDE53963E84DF51571027342" xlink:type="locator" />
    <presentationArc order="17" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ProductsAndServicesDomain_064B60263C2B188A9A08F51571029B66" xlink:to="loc_lly_CialisMember_EE5256A0DDE53963E84DF51571027342" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_EffientMember" xlink:label="loc_lly_EffientMember_69D4F2B434425CE6781FF51571027AA3" xlink:type="locator" />
    <presentationArc order="18" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ProductsAndServicesDomain_064B60263C2B188A9A08F51571029B66" xlink:to="loc_lly_EffientMember_69D4F2B434425CE6781FF51571027AA3" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_OtherCardiovascularMember" xlink:label="loc_lly_OtherCardiovascularMember_E230C2BA44DE5B31A507F51571021216" xlink:type="locator" />
    <presentationArc order="19" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ProductsAndServicesDomain_064B60263C2B188A9A08F51571029B66" xlink:to="loc_lly_OtherCardiovascularMember_E230C2BA44DE5B31A507F51571021216" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_BiCompoundsMember" xlink:label="loc_lly_BiCompoundsMember_F4A3EE4C19D12755DB54F515710286DC" xlink:type="locator" />
    <presentationArc order="20" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ProductsAndServicesDomain_064B60263C2B188A9A08F51571029B66" xlink:to="loc_lly_BiCompoundsMember_F4A3EE4C19D12755DB54F515710286DC" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StatementBusinessSegmentsAxis" xlink:label="loc_us-gaap_StatementBusinessSegmentsAxis_3246C074E19A036DF005F51571028F84" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_A4FEFB48786E53785842F51571028CD1" xlink:to="loc_us-gaap_StatementBusinessSegmentsAxis_3246C074E19A036DF005F51571028F84" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_SegmentDomain" xlink:label="loc_us-gaap_SegmentDomain_9F9257176A3AFA6ACF96F5157102859B" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_3246C074E19A036DF005F51571028F84" xlink:to="loc_us-gaap_SegmentDomain_9F9257176A3AFA6ACF96F5157102859B" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_HumanPharmaceuticalProductsMember" xlink:label="loc_lly_HumanPharmaceuticalProductsMember_215D98D5E6179E084CE5F5157102219B" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentDomain_9F9257176A3AFA6ACF96F5157102859B" xlink:to="loc_lly_HumanPharmaceuticalProductsMember_215D98D5E6179E084CE5F5157102219B" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_TotalSegmentMember" xlink:label="loc_lly_TotalSegmentMember_0639D4494D40F0F017AEF51571028672" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentDomain_9F9257176A3AFA6ACF96F5157102859B" xlink:to="loc_lly_TotalSegmentMember_0639D4494D40F0F017AEF51571028672" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_EndocrinologyMember" xlink:label="loc_lly_EndocrinologyMember_4EDE339259D22AE91F30F5157102169E" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentDomain_9F9257176A3AFA6ACF96F5157102859B" xlink:to="loc_lly_EndocrinologyMember_4EDE339259D22AE91F30F5157102169E" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_NeuroscienceMember" xlink:label="loc_lly_NeuroscienceMember_525990EEBFEB2457486AF515710284F4" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentDomain_9F9257176A3AFA6ACF96F5157102859B" xlink:to="loc_lly_NeuroscienceMember_525990EEBFEB2457486AF515710284F4" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_OncologyMember" xlink:label="loc_lly_OncologyMember_C42D75616B3D1A758BB4F51571022E0F" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentDomain_9F9257176A3AFA6ACF96F5157102859B" xlink:to="loc_lly_OncologyMember_C42D75616B3D1A758BB4F51571022E0F" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_CardiovascularMember" xlink:label="loc_lly_CardiovascularMember_19AC06661003A34DE6CFF5157102921E" xlink:type="locator" />
    <presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentDomain_9F9257176A3AFA6ACF96F5157102859B" xlink:to="loc_lly_CardiovascularMember_19AC06661003A34DE6CFF5157102921E" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_OtherPharmaceuticalsMember" xlink:label="loc_lly_OtherPharmaceuticalsMember_7ED6C1B2F786DF1BF885F51571023EF9" xlink:type="locator" />
    <presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentDomain_9F9257176A3AFA6ACF96F5157102859B" xlink:to="loc_lly_OtherPharmaceuticalsMember_7ED6C1B2F786DF1BF885F51571023EF9" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_PharmaceuticalProductsTotalMember" xlink:label="loc_lly_PharmaceuticalProductsTotalMember_9ACC4BAF9A2EC5490FC0F5157102A757" xlink:type="locator" />
    <presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentDomain_9F9257176A3AFA6ACF96F5157102859B" xlink:to="loc_lly_PharmaceuticalProductsTotalMember_9ACC4BAF9A2EC5490FC0F5157102A757" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_AnimalHealthProductsMember" xlink:label="loc_lly_AnimalHealthProductsMember_D524CC085C3B89DA3382F5157102BBC4" xlink:type="locator" />
    <presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentDomain_9F9257176A3AFA6ACF96F5157102859B" xlink:to="loc_lly_AnimalHealthProductsMember_D524CC085C3B89DA3382F5157102BBC4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CorporateNonSegmentMember" xlink:label="loc_us-gaap_CorporateNonSegmentMember_6FFDF1765AA84BD83510F51571022B35" xlink:type="locator" />
    <presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentDomain_9F9257176A3AFA6ACF96F5157102859B" xlink:to="loc_us-gaap_CorporateNonSegmentMember_6FFDF1765AA84BD83510F51571022B35" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StatementGeographicalAxis" xlink:label="loc_us-gaap_StatementGeographicalAxis_DF5C82780F0FAC02F21AF51571023318" xlink:type="locator" />
    <presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_A4FEFB48786E53785842F51571028CD1" xlink:to="loc_us-gaap_StatementGeographicalAxis_DF5C82780F0FAC02F21AF51571023318" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_SegmentGeographicalDomain" xlink:label="loc_us-gaap_SegmentGeographicalDomain_A40529CD10EF507C02D2F5157102E82D" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementGeographicalAxis_DF5C82780F0FAC02F21AF51571023318" xlink:to="loc_us-gaap_SegmentGeographicalDomain_A40529CD10EF507C02D2F5157102E82D" xlink:type="arc" />
    <loc xlink:href="http://xbrl.sec.gov/country/2013/country-2013-01-31.xsd#country_US" xlink:label="loc_country_US_A2B8D9E61AFA2B55872FF515710225AE" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentGeographicalDomain_A40529CD10EF507C02D2F5157102E82D" xlink:to="loc_country_US_A2B8D9E61AFA2B55872FF515710225AE" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_EuropeMember" xlink:label="loc_us-gaap_EuropeMember_B296F7AE2230DC944BDFF51571020888" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentGeographicalDomain_A40529CD10EF507C02D2F5157102E82D" xlink:to="loc_us-gaap_EuropeMember_B296F7AE2230DC944BDFF51571020888" xlink:type="arc" />
    <loc xlink:href="http://xbrl.sec.gov/country/2013/country-2013-01-31.xsd#country_JP" xlink:label="loc_country_JP_4B87F2D2CD2C01DE2043F5157102B325" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentGeographicalDomain_A40529CD10EF507C02D2F5157102E82D" xlink:to="loc_country_JP_4B87F2D2CD2C01DE2043F5157102B325" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_OtherForeignCountriesMember" xlink:label="loc_lly_OtherForeignCountriesMember_220ADBBEAC2D75E88CEBF51571025F4B" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentGeographicalDomain_A40529CD10EF507C02D2F5157102E82D" xlink:to="loc_lly_OtherForeignCountriesMember_220ADBBEAC2D75E88CEBF51571025F4B" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ConcentrationRiskByBenchmarkAxis" xlink:label="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_A9AE38380DD82D964223F5157102D28A" xlink:type="locator" />
    <presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_A4FEFB48786E53785842F51571028CD1" xlink:to="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_A9AE38380DD82D964223F5157102D28A" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ConcentrationRiskBenchmarkDomain" xlink:label="loc_us-gaap_ConcentrationRiskBenchmarkDomain_71B93861569FA4739973F51571023890" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_A9AE38380DD82D964223F5157102D28A" xlink:to="loc_us-gaap_ConcentrationRiskBenchmarkDomain_71B93861569FA4739973F51571023890" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_SalesRevenueGoodsNetMember" xlink:label="loc_us-gaap_SalesRevenueGoodsNetMember_F42F91C2C0672B39C3F4F515710261F3" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ConcentrationRiskBenchmarkDomain_71B93861569FA4739973F51571023890" xlink:to="loc_us-gaap_SalesRevenueGoodsNetMember_F42F91C2C0672B39C3F4F515710261F3" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AccountsReceivableMember" xlink:label="loc_us-gaap_AccountsReceivableMember_FC7EAA3C3DEA37CA5825F51571024BA4" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ConcentrationRiskBenchmarkDomain_71B93861569FA4739973F51571023890" xlink:to="loc_us-gaap_AccountsReceivableMember_FC7EAA3C3DEA37CA5825F51571024BA4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_SegmentReportingInformationLineItems" xlink:label="loc_us-gaap_SegmentReportingInformationLineItems_53F228EF2B75879A9685F5157102110E" xlink:type="locator" />
    <presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_A4FEFB48786E53785842F51571028CD1" xlink:to="loc_us-gaap_SegmentReportingInformationLineItems_53F228EF2B75879A9685F5157102110E" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OtherDepreciationAndAmortization" xlink:label="loc_us-gaap_OtherDepreciationAndAmortization_872AD56EB8BB8636F3B2F51571025DAA" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_53F228EF2B75879A9685F5157102110E" xlink:to="loc_us-gaap_OtherDepreciationAndAmortization_872AD56EB8BB8636F3B2F51571025DAA" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DepreciationDepletionAndAmortization" xlink:label="loc_us-gaap_DepreciationDepletionAndAmortization_514287D92CD5986580F8F51571022772" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_53F228EF2B75879A9685F5157102110E" xlink:to="loc_us-gaap_DepreciationDepletionAndAmortization_514287D92CD5986580F8F51571022772" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_Revenues" xlink:label="loc_us-gaap_Revenues_3F17185925DA9F123D09F5157102E777" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_53F228EF2B75879A9685F5157102110E" xlink:to="loc_us-gaap_Revenues_3F17185925DA9F123D09F5157102E777" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OtherSalesRevenueNet" xlink:label="loc_us-gaap_OtherSalesRevenueNet_6EDE9627F4882D0AFBEAF51571025CFD" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_53F228EF2B75879A9685F5157102110E" xlink:to="loc_us-gaap_OtherSalesRevenueNet_6EDE9627F4882D0AFBEAF51571025CFD" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_NoncurrentAssets" xlink:label="loc_us-gaap_NoncurrentAssets_C4FCE0EDCAF1F0567915F51571024CB8" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_53F228EF2B75879A9685F5157102110E" xlink:to="loc_us-gaap_NoncurrentAssets_C4FCE0EDCAF1F0567915F51571024CB8" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_RestructuringSettlementAndImpairmentProvisions" xlink:label="loc_us-gaap_RestructuringSettlementAndImpairmentProvisions_9A6CE0833A8D019C8DF4F5157112F012" xlink:type="locator" />
    <presentationArc order="6" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_53F228EF2B75879A9685F5157102110E" xlink:to="loc_us-gaap_RestructuringSettlementAndImpairmentProvisions_9A6CE0833A8D019C8DF4F5157112F012" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_SellingGeneralAndAdministrativeExpense" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpense_24202B88B9C0C839AFCDF51571126824" xlink:type="locator" />
    <presentationArc order="7" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_53F228EF2B75879A9685F5157102110E" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpense_24202B88B9C0C839AFCDF51571126824" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_874B552B28696F729A79F5157112CC25" xlink:type="locator" />
    <presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_53F228EF2B75879A9685F5157102110E" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_874B552B28696F729A79F5157112CC25" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CostOfGoodsSold" xlink:label="loc_us-gaap_CostOfGoodsSold_31F69ACF6E8E6B980FD7F51571122279" xlink:type="locator" />
    <presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_53F228EF2B75879A9685F5157102110E" xlink:to="loc_us-gaap_CostOfGoodsSold_31F69ACF6E8E6B980FD7F51571122279" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ConcentrationRiskPercentage1" xlink:label="loc_us-gaap_ConcentrationRiskPercentage1_153E4C4FA86DD2926E16F5157112B266" xlink:type="locator" />
    <presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_53F228EF2B75879A9685F5157102110E" xlink:to="loc_us-gaap_ConcentrationRiskPercentage1_153E4C4FA86DD2926E16F5157112B266" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_AcquiredInProcessResearchAndDevelopment" xlink:label="loc_lly_AcquiredInProcessResearchAndDevelopment_A3CC86EF0FB23945D92DF5157112612A" xlink:type="locator" />
    <presentationArc order="11" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_53F228EF2B75879A9685F5157102110E" xlink:to="loc_lly_AcquiredInProcessResearchAndDevelopment_A3CC86EF0FB23945D92DF5157112612A" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_GainLossOnContractTermination" xlink:label="loc_us-gaap_GainLossOnContractTermination_93E3D41D294D12426214F51571125B28" xlink:type="locator" />
    <presentationArc order="12" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_53F228EF2B75879A9685F5157102110E" xlink:to="loc_us-gaap_GainLossOnContractTermination_93E3D41D294D12426214F51571125B28" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_NonoperatingIncomeExpense" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_A81B5BC0AA3E47D294F3F5157112AE8C" xlink:type="locator" />
    <presentationArc order="13" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_53F228EF2B75879A9685F5157102110E" xlink:to="loc_us-gaap_NonoperatingIncomeExpense_A81B5BC0AA3E47D294F3F5157112AE8C" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AmortizationOfIntangibleAssets" xlink:label="loc_us-gaap_AmortizationOfIntangibleAssets_9F49631EF6EDD77DD7A6F515711227FE" xlink:type="locator" />
    <presentationArc order="14" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_53F228EF2B75879A9685F5157102110E" xlink:to="loc_us-gaap_AmortizationOfIntangibleAssets_9F49631EF6EDD77DD7A6F515711227FE" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_GainsLossesOnExtinguishmentOfDebt" xlink:label="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_39E38A3D989B0D80EDE2F51571127374" xlink:type="locator" />
    <presentationArc order="15" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_53F228EF2B75879A9685F5157102110E" xlink:to="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_39E38A3D989B0D80EDE2F51571127374" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.lilly.com/role/SegmentInformationSegmentInformationTables" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_SegmentReportingAbstract" xlink:label="loc_us-gaap_SegmentReportingAbstract_112CAF228B0B92C82C25F4DF24ADB4D0" xlink:type="locator" />
    <loc xlink:href="lly-20151231.xsd#lly_ScheduleofAdditionalSegmentInformationDisclosuresTableTextBlock" xlink:label="loc_lly_ScheduleofAdditionalSegmentInformationDisclosuresTableTextBlock_8BB45E9E558647FC6E9DF4DFB39411BA" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentReportingAbstract_112CAF228B0B92C82C25F4DF24ADB4D0" xlink:to="loc_lly_ScheduleofAdditionalSegmentInformationDisclosuresTableTextBlock_8BB45E9E558647FC6E9DF4DFB39411BA" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ReconciliationOfOperatingProfitLossFromSegmentsToConsolidatedTextBlock" xlink:label="loc_us-gaap_ReconciliationOfOperatingProfitLossFromSegmentsToConsolidatedTextBlock_95628034247241337F8AF4DF24AD6BC1" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentReportingAbstract_112CAF228B0B92C82C25F4DF24ADB4D0" xlink:to="loc_us-gaap_ReconciliationOfOperatingProfitLossFromSegmentsToConsolidatedTextBlock_95628034247241337F8AF4DF24AD6BC1" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScheduleOfRevenuesFromExternalCustomersAndLongLivedAssetsByGeographicalAreasTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfRevenuesFromExternalCustomersAndLongLivedAssetsByGeographicalAreasTableTextBlock_1EEB5A4268E6B3D7067CF4DF24AD771F" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SegmentReportingAbstract_112CAF228B0B92C82C25F4DF24ADB4D0" xlink:to="loc_us-gaap_ScheduleOfRevenuesFromExternalCustomersAndLongLivedAssetsByGeographicalAreasTableTextBlock_1EEB5A4268E6B3D7067CF4DF24AD771F" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.lilly.com/role/SelectedQuarterlyDataDetails" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_QuarterlyFinancialInformationDisclosureAbstract" xlink:label="loc_us-gaap_QuarterlyFinancialInformationDisclosureAbstract_A41FCD10C7F4DBF42E47F698CEFC813C" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StatementTable" xlink:label="loc_us-gaap_StatementTable_1F1F6504545632F497D1F5374800CC95" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_QuarterlyFinancialInformationDisclosureAbstract_A41FCD10C7F4DBF42E47F698CEFC813C" xlink:to="loc_us-gaap_StatementTable_1F1F6504545632F497D1F5374800CC95" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_RangeAxis" xlink:label="loc_us-gaap_RangeAxis_BE1930ADE652AD658AE8F53748008749" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_1F1F6504545632F497D1F5374800CC95" xlink:to="loc_us-gaap_RangeAxis_BE1930ADE652AD658AE8F53748008749" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_RangeMember" xlink:label="loc_us-gaap_RangeMember_A0AC9C7510F7A984C714F53748002F5E" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RangeAxis_BE1930ADE652AD658AE8F53748008749" xlink:to="loc_us-gaap_RangeMember_A0AC9C7510F7A984C714F53748002F5E" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_MaximumMember" xlink:label="loc_us-gaap_MaximumMember_A543ADED7515168808C6F5374800755B" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RangeMember_A0AC9C7510F7A984C714F53748002F5E" xlink:to="loc_us-gaap_MaximumMember_A543ADED7515168808C6F5374800755B" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_MinimumMember" xlink:label="loc_us-gaap_MinimumMember_CC16C9D86AC53C5E1E3FF5374800520A" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RangeMember_A0AC9C7510F7A984C714F53748002F5E" xlink:to="loc_us-gaap_MinimumMember_CC16C9D86AC53C5E1E3FF5374800520A" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_FD975E6655659EE5EB5EF53748004D03" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_1F1F6504545632F497D1F5374800CC95" xlink:to="loc_us-gaap_StatementLineItems_FD975E6655659EE5EB5EF53748004D03" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_Revenues" xlink:label="loc_us-gaap_Revenues_B746786B718AA03A1236F5374800F311" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_FD975E6655659EE5EB5EF53748004D03" xlink:to="loc_us-gaap_Revenues_B746786B718AA03A1236F5374800F311" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CostOfGoodsSold" xlink:label="loc_us-gaap_CostOfGoodsSold_FC049BCACF0A5ADEB73FF53748008B28" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_FD975E6655659EE5EB5EF53748004D03" xlink:to="loc_us-gaap_CostOfGoodsSold_FC049BCACF0A5ADEB73FF53748008B28" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OperatingExpenses" xlink:label="loc_us-gaap_OperatingExpenses_60446492CAFED3F4799CF5374800CD41" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_FD975E6655659EE5EB5EF53748004D03" xlink:to="loc_us-gaap_OperatingExpenses_60446492CAFED3F4799CF5374800CD41" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_AcquiredInProcessResearchAndDevelopment" xlink:label="loc_lly_AcquiredInProcessResearchAndDevelopment_AF9AF20002DC1501669FF53748005CF2" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_FD975E6655659EE5EB5EF53748004D03" xlink:to="loc_lly_AcquiredInProcessResearchAndDevelopment_AF9AF20002DC1501669FF53748005CF2" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_RestructuringSettlementAndImpairmentProvisions" xlink:label="loc_us-gaap_RestructuringSettlementAndImpairmentProvisions_B872F9AD3FF137DAD279F53748049781" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_FD975E6655659EE5EB5EF53748004D03" xlink:to="loc_us-gaap_RestructuringSettlementAndImpairmentProvisions_B872F9AD3FF137DAD279F53748049781" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_NonoperatingIncomeExpense" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_F3769732DAC0639167DDF53748053E03" xlink:type="locator" />
    <presentationArc order="6" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_FD975E6655659EE5EB5EF53748004D03" xlink:to="loc_us-gaap_NonoperatingIncomeExpense_F3769732DAC0639167DDF53748053E03" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_6D6E520B332A51D232D5F537480553EF" xlink:type="locator" />
    <presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_FD975E6655659EE5EB5EF53748004D03" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_6D6E520B332A51D232D5F537480553EF" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_NetIncomeLoss" xlink:label="loc_us-gaap_NetIncomeLoss_44C5B8152F14BC268B88F5374805C310" xlink:type="locator" />
    <presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_FD975E6655659EE5EB5EF53748004D03" xlink:to="loc_us-gaap_NetIncomeLoss_44C5B8152F14BC268B88F5374805C310" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_EarningsPerShareBasic" xlink:label="loc_us-gaap_EarningsPerShareBasic_828A9E77F88E7667E76BF5374805A5DF" xlink:type="locator" />
    <presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_FD975E6655659EE5EB5EF53748004D03" xlink:to="loc_us-gaap_EarningsPerShareBasic_828A9E77F88E7667E76BF5374805A5DF" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_EarningsPerShareDiluted" xlink:label="loc_us-gaap_EarningsPerShareDiluted_1F0D80A8B01C8A34C7C7F5374805E550" xlink:type="locator" />
    <presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_FD975E6655659EE5EB5EF53748004D03" xlink:to="loc_us-gaap_EarningsPerShareDiluted_1F0D80A8B01C8A34C7C7F5374805E550" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CommonStockDividendsPerShareCashPaid" xlink:label="loc_us-gaap_CommonStockDividendsPerShareCashPaid_A978D51EAFD29CD3973AF5374805D724" xlink:type="locator" />
    <presentationArc order="11" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_FD975E6655659EE5EB5EF53748004D03" xlink:to="loc_us-gaap_CommonStockDividendsPerShareCashPaid_A978D51EAFD29CD3973AF5374805D724" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_SharePrice" xlink:label="loc_us-gaap_SharePrice_D6EAA756DB3F82B91816F537480524A5" xlink:type="locator" />
    <presentationArc order="12" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_FD975E6655659EE5EB5EF53748004D03" xlink:to="loc_us-gaap_SharePrice_D6EAA756DB3F82B91816F537480524A5" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.lilly.com/role/SelectedQuarterlyDataNotes" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_QuarterlyFinancialInformationDisclosureAbstract" xlink:label="loc_us-gaap_QuarterlyFinancialInformationDisclosureAbstract_1706CEE38366BB9BB876FC036F156185" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_QuarterlyFinancialInformationTextBlock" xlink:label="loc_us-gaap_QuarterlyFinancialInformationTextBlock_7B5C0A25B10019ABBA6BFC036F156917" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_QuarterlyFinancialInformationDisclosureAbstract_1706CEE38366BB9BB876FC036F156185" xlink:to="loc_us-gaap_QuarterlyFinancialInformationTextBlock_7B5C0A25B10019ABBA6BFC036F156917" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.lilly.com/role/SelectedQuarterlyDataTables" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_QuarterlyFinancialInformationDisclosureAbstract" xlink:label="loc_us-gaap_QuarterlyFinancialInformationDisclosureAbstract_415486D5F0A99ED9A620FC036E756D03" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScheduleOfQuarterlyFinancialInformationTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfQuarterlyFinancialInformationTableTextBlock_AC79D2142ED5A23C7C19FC036E7563F4" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_QuarterlyFinancialInformationDisclosureAbstract_415486D5F0A99ED9A620FC036E756D03" xlink:to="loc_us-gaap_ScheduleOfQuarterlyFinancialInformationTableTextBlock_AC79D2142ED5A23C7C19FC036E7563F4" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.lilly.com/role/ShareholdersEquity" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StockholdersEquityNoteAbstract" xlink:label="loc_us-gaap_StockholdersEquityNoteAbstract_9C0DDE4A6B450A64C82CFC0370F5B623" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StockholdersEquityNoteDisclosureTextBlock" xlink:label="loc_us-gaap_StockholdersEquityNoteDisclosureTextBlock_793593C6E08CC409BD6AFC0370F57583" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityNoteAbstract_9C0DDE4A6B450A64C82CFC0370F5B623" xlink:to="loc_us-gaap_StockholdersEquityNoteDisclosureTextBlock_793593C6E08CC409BD6AFC0370F57583" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.lilly.com/role/ShareholdersEquityDetails" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StockholdersEquityNoteAbstract" xlink:label="loc_us-gaap_StockholdersEquityNoteAbstract_BBBDE6D7C11E87CE7829FA012D8BFEB0" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScheduleOfStockByClassTable" xlink:label="loc_us-gaap_ScheduleOfStockByClassTable_F040617D78D043CB7AC2FA012D8B3F83" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityNoteAbstract_BBBDE6D7C11E87CE7829FA012D8BFEB0" xlink:to="loc_us-gaap_ScheduleOfStockByClassTable_F040617D78D043CB7AC2FA012D8B3F83" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StatementEquityComponentsAxis" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_81F7FE95B874CD73AA46FA012D8B6A63" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_F040617D78D043CB7AC2FA012D8B3F83" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_81F7FE95B874CD73AA46FA012D8B6A63" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_EquityComponentDomain" xlink:label="loc_us-gaap_EquityComponentDomain_1D81362E1281F3669888FA012D8B8050" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_81F7FE95B874CD73AA46FA012D8B6A63" xlink:to="loc_us-gaap_EquityComponentDomain_1D81362E1281F3669888FA012D8B8050" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AdditionalPaidInCapitalMember" xlink:label="loc_us-gaap_AdditionalPaidInCapitalMember_B099A470E074F7259279FA012D8B3E9D" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_1D81362E1281F3669888FA012D8B8050" xlink:to="loc_us-gaap_AdditionalPaidInCapitalMember_B099A470E074F7259279FA012D8B3E9D" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_RetainedEarningsMember" xlink:label="loc_us-gaap_RetainedEarningsMember_5F9D68BDD51EF924F61AFA012D8B29AE" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_1D81362E1281F3669888FA012D8B8050" xlink:to="loc_us-gaap_RetainedEarningsMember_5F9D68BDD51EF924F61AFA012D8B29AE" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_TreasuryStockMember" xlink:label="loc_us-gaap_TreasuryStockMember_0932A8844324D02DE462FA012D8BEA4F" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_1D81362E1281F3669888FA012D8B8050" xlink:to="loc_us-gaap_TreasuryStockMember_0932A8844324D02DE462FA012D8BEA4F" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_A2012ShareRepurchaseProgramMember" xlink:label="loc_lly_A2012ShareRepurchaseProgramMember_7A3C6229AA6F2016FA6FFA012D8B3F9B" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_1D81362E1281F3669888FA012D8B8050" xlink:to="loc_lly_A2012ShareRepurchaseProgramMember_7A3C6229AA6F2016FA6FFA012D8B3F9B" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_A2013ShareRepurchaseProgramMember" xlink:label="loc_lly_A2013ShareRepurchaseProgramMember_A0539A84CBDAD91A540AFA012D8B19C3" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_1D81362E1281F3669888FA012D8B8050" xlink:to="loc_lly_A2013ShareRepurchaseProgramMember_A0539A84CBDAD91A540AFA012D8B19C3" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_9D354634478677AF00A1FA012D8B5A42" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_F040617D78D043CB7AC2FA012D8B3F83" xlink:to="loc_us-gaap_StatementLineItems_9D354634478677AF00A1FA012D8B5A42" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_TreasuryStockValueAcquiredCostMethod" xlink:label="loc_us-gaap_TreasuryStockValueAcquiredCostMethod_45838E6DD1EEB9936838FA012D8B4768" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_9D354634478677AF00A1FA012D8B5A42" xlink:to="loc_us-gaap_TreasuryStockValueAcquiredCostMethod_45838E6DD1EEB9936838FA012D8B4768" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_95846F11ED40FAED3251FA012D8BA69B" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_9D354634478677AF00A1FA012D8B5A42" xlink:to="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_95846F11ED40FAED3251FA012D8BA69B" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_TreasuryStockShares" xlink:label="loc_us-gaap_TreasuryStockShares_BADA43D672A72A3FD4B0FA012D8B57D0" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_9D354634478677AF00A1FA012D8B5A42" xlink:to="loc_us-gaap_TreasuryStockShares_BADA43D672A72A3FD4B0FA012D8B57D0" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_NetIncomeLoss" xlink:label="loc_us-gaap_NetIncomeLoss_D5784DDB138997F67EF3FA012D8B3CCC" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_9D354634478677AF00A1FA012D8B5A42" xlink:to="loc_us-gaap_NetIncomeLoss_D5784DDB138997F67EF3FA012D8B3CCC" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_TreasuryStockRetiredCostMethodAmount" xlink:label="loc_us-gaap_TreasuryStockRetiredCostMethodAmount_111B50BE99037F33E22FFA012D8BEA94" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_9D354634478677AF00A1FA012D8B5A42" xlink:to="loc_us-gaap_TreasuryStockRetiredCostMethodAmount_111B50BE99037F33E22FFA012D8BEA94" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StockRepurchaseProgramAuthorizedAmount1" xlink:label="loc_us-gaap_StockRepurchaseProgramAuthorizedAmount1_85A24729B0A12BFE55F7FA012D8BE3F8" xlink:type="locator" />
    <presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_9D354634478677AF00A1FA012D8B5A42" xlink:to="loc_us-gaap_StockRepurchaseProgramAuthorizedAmount1_85A24729B0A12BFE55F7FA012D8BE3F8" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StockRepurchaseProgramRemainingAuthorizedRepurchaseAmount1" xlink:label="loc_us-gaap_StockRepurchaseProgramRemainingAuthorizedRepurchaseAmount1_5E263ECCCDDE4545CC16FA012D8B514E" xlink:type="locator" />
    <presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_9D354634478677AF00A1FA012D8B5A42" xlink:to="loc_us-gaap_StockRepurchaseProgramRemainingAuthorizedRepurchaseAmount1_5E263ECCCDDE4545CC16FA012D8B514E" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_TreasuryStockSharesRetired" xlink:label="loc_us-gaap_TreasuryStockSharesRetired_A07B8510C0F19AEAFA7BFA012D8BE92E" xlink:type="locator" />
    <presentationArc order="8" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_9D354634478677AF00A1FA012D8B5A42" xlink:to="loc_us-gaap_TreasuryStockSharesRetired_A07B8510C0F19AEAFA7BFA012D8BE92E" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PreferredStockSharesAuthorized" xlink:label="loc_us-gaap_PreferredStockSharesAuthorized_602429B8C64F6E4CBDE7FA012D8B93CC" xlink:type="locator" />
    <presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_9D354634478677AF00A1FA012D8B5A42" xlink:to="loc_us-gaap_PreferredStockSharesAuthorized_602429B8C64F6E4CBDE7FA012D8B93CC" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PreferredStockSharesIssued" xlink:label="loc_us-gaap_PreferredStockSharesIssued_0BBC5CF11DCDC496FE60FA012D8B7527" xlink:type="locator" />
    <presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_9D354634478677AF00A1FA012D8B5A42" xlink:to="loc_us-gaap_PreferredStockSharesIssued_0BBC5CF11DCDC496FE60FA012D8B7527" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CommonStockSharesHeldInEmployeeTrustShares" xlink:label="loc_us-gaap_CommonStockSharesHeldInEmployeeTrustShares_4E1E980A044541C306CEFA012D8B1B18" xlink:type="locator" />
    <presentationArc order="11" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_9D354634478677AF00A1FA012D8B5A42" xlink:to="loc_us-gaap_CommonStockSharesHeldInEmployeeTrustShares_4E1E980A044541C306CEFA012D8B1B18" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CommonStockSharesHeldInEmployeeTrust" xlink:label="loc_us-gaap_CommonStockSharesHeldInEmployeeTrust_0F194EB8592D8D53EBC6FA012D8B45DE" xlink:type="locator" />
    <presentationArc order="12" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_9D354634478677AF00A1FA012D8B5A42" xlink:to="loc_us-gaap_CommonStockSharesHeldInEmployeeTrust_0F194EB8592D8D53EBC6FA012D8B45DE" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_5E6389D85CB010D3EDE7FA012D8BDE39" xlink:type="locator" />
    <presentationArc order="13" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_9D354634478677AF00A1FA012D8B5A42" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_5E6389D85CB010D3EDE7FA012D8BDE39" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AllocatedShareBasedCompensationExpense" xlink:label="loc_us-gaap_AllocatedShareBasedCompensationExpense_A3413C3FA4F79ABDBA22FA012D8BF392" xlink:type="locator" />
    <presentationArc order="14" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_9D354634478677AF00A1FA012D8B5A42" xlink:to="loc_us-gaap_AllocatedShareBasedCompensationExpense_A3413C3FA4F79ABDBA22FA012D8BF392" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CommonStockSharesIssued" xlink:label="loc_us-gaap_CommonStockSharesIssued_609D96FD4FBEB889C581FA012D8BF8BC" xlink:type="locator" />
    <presentationArc order="15" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_9D354634478677AF00A1FA012D8B5A42" xlink:to="loc_us-gaap_CommonStockSharesIssued_609D96FD4FBEB889C581FA012D8BF8BC" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.lilly.com/role/StockBasedCompensation" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_EmployeeServiceShareBasedCompensationAggregateDisclosuresAbstract" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationAggregateDisclosuresAbstract_54455A422320C61A8E9AFC036EE36E81" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DisclosureOfCompensationRelatedCostsShareBasedPaymentsTextBlock" xlink:label="loc_us-gaap_DisclosureOfCompensationRelatedCostsShareBasedPaymentsTextBlock_D38220697A30C401AA90FC036EE3E986" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAggregateDisclosuresAbstract_54455A422320C61A8E9AFC036EE36E81" xlink:to="loc_us-gaap_DisclosureOfCompensationRelatedCostsShareBasedPaymentsTextBlock_D38220697A30C401AA90FC036EE3E986" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.lilly.com/role/StockBasedCompensationDetails" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_EmployeeServiceShareBasedCompensationAggregateDisclosuresAbstract" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationAggregateDisclosuresAbstract_8604C202280917647B80F699B531C0B5" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_7AC8451AD593A33E89D2F53749ED02AD" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAggregateDisclosuresAbstract_8604C202280917647B80F699B531C0B5" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_7AC8451AD593A33E89D2F53749ED02AD" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AwardTypeAxis" xlink:label="loc_us-gaap_AwardTypeAxis_CA5F488C59802AB51CB9F53749ED29FA" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_7AC8451AD593A33E89D2F53749ED02AD" xlink:to="loc_us-gaap_AwardTypeAxis_CA5F488C59802AB51CB9F53749ED29FA" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_F316505AC3362451A2F2F53749EDE20B" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AwardTypeAxis_CA5F488C59802AB51CB9F53749ED29FA" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_F316505AC3362451A2F2F53749EDE20B" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PerformanceSharesMember" xlink:label="loc_us-gaap_PerformanceSharesMember_E6B7E1D66C03778C384BF53749ED4C95" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_F316505AC3362451A2F2F53749EDE20B" xlink:to="loc_us-gaap_PerformanceSharesMember_E6B7E1D66C03778C384BF53749ED4C95" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_ShareholderValueAwardsMember" xlink:label="loc_lly_ShareholderValueAwardsMember_C1A584735625DA644E6FF53749ED4D30" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_F316505AC3362451A2F2F53749EDE20B" xlink:to="loc_lly_ShareholderValueAwardsMember_C1A584735625DA644E6FF53749ED4D30" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_RestrictedStockUnitsRSUMember" xlink:label="loc_us-gaap_RestrictedStockUnitsRSUMember_D54917AEDBC35A50062EF53749EDAF74" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_F316505AC3362451A2F2F53749EDE20B" xlink:to="loc_us-gaap_RestrictedStockUnitsRSUMember_D54917AEDBC35A50062EF53749EDAF74" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_161625AA7609D40433B9F53749EDF0FD" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_7AC8451AD593A33E89D2F53749ED02AD" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_161625AA7609D40433B9F53749EDF0FD" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AllocatedShareBasedCompensationExpense" xlink:label="loc_us-gaap_AllocatedShareBasedCompensationExpense_D392B144641001E3BE03F53749EE3E57" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_161625AA7609D40433B9F53749EDF0FD" xlink:to="loc_us-gaap_AllocatedShareBasedCompensationExpense_D392B144641001E3BE03F53749EE3E57" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_EmployeeServiceShareBasedCompensationTaxBenefitFromCompensationExpense" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationTaxBenefitFromCompensationExpense_A73FA99C0C5B5B56BF85F53749EEFDB6" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_161625AA7609D40433B9F53749EDF0FD" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationTaxBenefitFromCompensationExpense_A73FA99C0C5B5B56BF85F53749EEFDB6" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognized" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognized_48EB98BAAC9093DE8C02F53749EE6F25" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_161625AA7609D40433B9F53749EDF0FD" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognized_48EB98BAAC9093DE8C02F53749EE6F25" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1_0A09623518BACCF41039F53749EEDAB3" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_161625AA7609D40433B9F53749EDF0FD" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1_0A09623518BACCF41039F53749EEDAB3" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant_D5E28FAE08BC84004F50F53749EE83D8" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_161625AA7609D40433B9F53749EDF0FD" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant_D5E28FAE08BC84004F50F53749EE83D8" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesIssuedInPeriod" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesIssuedInPeriod_9531A1BF7905A8B80545F53749EEDFBA" xlink:type="locator" />
    <presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_161625AA7609D40433B9F53749EDF0FD" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesIssuedInPeriod_9531A1BF7905A8B80545F53749EEDFBA" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_ShareBasedCompensationArrangementByShareBasedPaymentAwardExpectedSharesToBeIssued" xlink:label="loc_lly_ShareBasedCompensationArrangementByShareBasedPaymentAwardExpectedSharesToBeIssued_24289565E039B7DC395DF53749EE6513" xlink:type="locator" />
    <presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_161625AA7609D40433B9F53749EDF0FD" xlink:to="loc_lly_ShareBasedCompensationArrangementByShareBasedPaymentAwardExpectedSharesToBeIssued_24289565E039B7DC395DF53749EE6513" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_0B0230A9DB0D8205F588F53749EE236F" xlink:type="locator" />
    <presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_161625AA7609D40433B9F53749EDF0FD" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_0B0230A9DB0D8205F588F53749EE236F" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate_025D41515B43FC96DDA0F53749EEAA34" xlink:type="locator" />
    <presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_161625AA7609D40433B9F53749EDF0FD" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate_025D41515B43FC96DDA0F53749EEAA34" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate_F61950FAC32338EA88EAF53749EE1D62" xlink:type="locator" />
    <presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_161625AA7609D40433B9F53749EDF0FD" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate_F61950FAC32338EA88EAF53749EE1D62" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMaximum" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMaximum_AE0AF4FF7DD231EA0FF0F53749EECD0A" xlink:type="locator" />
    <presentationArc order="11" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_161625AA7609D40433B9F53749EDF0FD" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMaximum_AE0AF4FF7DD231EA0FF0F53749EECD0A" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate_1AE2C6932CBBE334FAECF53749EE01BF" xlink:type="locator" />
    <presentationArc order="12" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_161625AA7609D40433B9F53749EDF0FD" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate_1AE2C6932CBBE334FAECF53749EE01BF" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMinimum" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMinimum_DF7172E89FEAF60ABDE4F53749EE43B1" xlink:type="locator" />
    <presentationArc order="13" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_161625AA7609D40433B9F53749EDF0FD" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMinimum_DF7172E89FEAF60ABDE4F53749EE43B1" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRateMinimum" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRateMinimum_83225BF7F07447CF4EBDF53749EE63CA" xlink:type="locator" />
    <presentationArc order="14" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_161625AA7609D40433B9F53749EDF0FD" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRateMinimum_83225BF7F07447CF4EBDF53749EE63CA" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRateMaximum" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRateMaximum_8EBADFBAD1468F3FA475F53749EED69E" xlink:type="locator" />
    <presentationArc order="15" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_161625AA7609D40433B9F53749EDF0FD" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRateMaximum_8EBADFBAD1468F3FA475F53749EED69E" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod_8B08F27F02BC1A129422F53749EED0EE" xlink:type="locator" />
    <presentationArc order="16" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_161625AA7609D40433B9F53749EDF0FD" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod_8B08F27F02BC1A129422F53749EED0EE" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod_BFD2717FDF2BE08C9414F53749EF97B2" xlink:type="locator" />
    <presentationArc order="17" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_161625AA7609D40433B9F53749EDF0FD" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod_BFD2717FDF2BE08C9414F53749EF97B2" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1_A4F3755CF555F1D9CE1BF53749EF5E59" xlink:type="locator" />
    <presentationArc order="18" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_161625AA7609D40433B9F53749EDF0FD" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1_A4F3755CF555F1D9CE1BF53749EF5E59" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.lilly.com/role/StockBasedCompensationStockBasedCompensationPolicies" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract" xlink:label="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_E4A9CE32C3181E48AFE5FC036EB1242E" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ShareBasedCompensationOptionAndIncentivePlansPolicy" xlink:label="loc_us-gaap_ShareBasedCompensationOptionAndIncentivePlansPolicy_B9162A35DAD82954C6CFFC036EB1A52F" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_E4A9CE32C3181E48AFE5FC036EB1242E" xlink:to="loc_us-gaap_ShareBasedCompensationOptionAndIncentivePlansPolicy_B9162A35DAD82954C6CFFC036EB1A52F" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.lilly.com/role/StockBasedCompensationTables" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_EmployeeServiceShareBasedCompensationAggregateDisclosuresAbstract" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationAggregateDisclosuresAbstract_738ECD671ADFFA7E4287FA012DA6C6DA" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_AEA0341875CC253E178FFA012DA6A951" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAggregateDisclosuresAbstract_738ECD671ADFFA7E4287FA012DA6C6DA" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_AEA0341875CC253E178FFA012DA6A951" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AwardTypeAxis" xlink:label="loc_us-gaap_AwardTypeAxis_CB6E93C64AA621F6F9E6FA012DA6E66E" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_AEA0341875CC253E178FFA012DA6A951" xlink:to="loc_us-gaap_AwardTypeAxis_CB6E93C64AA621F6F9E6FA012DA6E66E" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_8EE296A98017A0EB5D95FA012DA7BC67" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AwardTypeAxis_CB6E93C64AA621F6F9E6FA012DA6E66E" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_8EE296A98017A0EB5D95FA012DA7BC67" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_ShareholderValueAwardsMember" xlink:label="loc_lly_ShareholderValueAwardsMember_735E341D1E43C834FE0CFA012DA753F3" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_8EE296A98017A0EB5D95FA012DA7BC67" xlink:to="loc_lly_ShareholderValueAwardsMember_735E341D1E43C834FE0CFA012DA753F3" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_366CD932003BCFD8BDDEFA012DA73B72" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_AEA0341875CC253E178FFA012DA6A951" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_366CD932003BCFD8BDDEFA012DA73B72" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_ScheduleofAdditionalStockBasedCompensationDisclosuresTableTextBlock" xlink:label="loc_lly_ScheduleofAdditionalStockBasedCompensationDisclosuresTableTextBlock_BEF8F14A599D6F68651CFA012DA740ED" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_366CD932003BCFD8BDDEFA012DA73B72" xlink:to="loc_lly_ScheduleofAdditionalStockBasedCompensationDisclosuresTableTextBlock_BEF8F14A599D6F68651CFA012DA740ED" xlink:type="arc" />
    <loc xlink:href="lly-20151231.xsd#lly_SharebasedCompensationAwardsFairValueAssumptionsUsedTableTextBlock" xlink:label="loc_lly_SharebasedCompensationAwardsFairValueAssumptionsUsedTableTextBlock_EDE6272D172A67F30FABFA012DA74B5E" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_366CD932003BCFD8BDDEFA012DA73B72" xlink:to="loc_lly_SharebasedCompensationAwardsFairValueAssumptionsUsedTableTextBlock_EDE6272D172A67F30FABFA012DA74B5E" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.lilly.com/role/SummaryOfSignificantAccountingPolicies" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AccountingPoliciesAbstract" xlink:label="loc_us-gaap_AccountingPoliciesAbstract_3A4A89A9D3EEEB48CBE3FC037005B84A" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTextBlock" xlink:label="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTextBlock_8FC345D54B00C7FA367DFC0370051A68" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_3A4A89A9D3EEEB48CBE3FC037005B84A" xlink:to="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTextBlock_8FC345D54B00C7FA367DFC0370051A68" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.lilly.com/role/SummaryOfSignificantAccountingPoliciesDetails" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AccountingPoliciesAbstract" xlink:label="loc_us-gaap_AccountingPoliciesAbstract_CC0DB19B16684133F5EFF5374AE57C6D" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StatementTable" xlink:label="loc_us-gaap_StatementTable_943EB0D1779617ADDE56F5374AE52632" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_CC0DB19B16684133F5EFF5374AE57C6D" xlink:to="loc_us-gaap_StatementTable_943EB0D1779617ADDE56F5374AE52632" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_RangeAxis" xlink:label="loc_us-gaap_RangeAxis_4316656B16BDD756AC42F5374AE5666A" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_943EB0D1779617ADDE56F5374AE52632" xlink:to="loc_us-gaap_RangeAxis_4316656B16BDD756AC42F5374AE5666A" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_RangeMember" xlink:label="loc_us-gaap_RangeMember_65CD3C74C39787E013EBF5374AE67C89" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RangeAxis_4316656B16BDD756AC42F5374AE5666A" xlink:to="loc_us-gaap_RangeMember_65CD3C74C39787E013EBF5374AE67C89" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_MinimumMember" xlink:label="loc_us-gaap_MinimumMember_D91C445A21260C57A029F5374AE62C56" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RangeMember_65CD3C74C39787E013EBF5374AE67C89" xlink:to="loc_us-gaap_MinimumMember_D91C445A21260C57A029F5374AE62C56" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_MaximumMember" xlink:label="loc_us-gaap_MaximumMember_4205670104EE6C0761F0F5374AE63B1F" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RangeMember_65CD3C74C39787E013EBF5374AE67C89" xlink:to="loc_us-gaap_MaximumMember_4205670104EE6C0761F0F5374AE63B1F" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PropertyPlantAndEquipmentByTypeAxis" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_EB28E5C3DF86EF93B854F5374AE67F85" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_943EB0D1779617ADDE56F5374AE52632" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_EB28E5C3DF86EF93B854F5374AE67F85" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_2AD84C554242AE3D4E13F5374AE6E0C4" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_EB28E5C3DF86EF93B854F5374AE67F85" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_2AD84C554242AE3D4E13F5374AE6E0C4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_BuildingMember" xlink:label="loc_us-gaap_BuildingMember_195BF33026EB2BA8FC7DF5374AE6B4EC" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_2AD84C554242AE3D4E13F5374AE6E0C4" xlink:to="loc_us-gaap_BuildingMember_195BF33026EB2BA8FC7DF5374AE6B4EC" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_EquipmentMember" xlink:label="loc_us-gaap_EquipmentMember_EDE4FDFCA32C7CD08F19F5374AE6E7A4" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_2AD84C554242AE3D4E13F5374AE6E0C4" xlink:to="loc_us-gaap_EquipmentMember_EDE4FDFCA32C7CD08F19F5374AE6E7A4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_B1E2E6228D808DD6C4BDF5374AE6A7E7" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_943EB0D1779617ADDE56F5374AE52632" xlink:to="loc_us-gaap_StatementLineItems_B1E2E6228D808DD6C4BDF5374AE6A7E7" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AverageRemainingMaturityOfForeignCurrencyDerivatives1" xlink:label="loc_us-gaap_AverageRemainingMaturityOfForeignCurrencyDerivatives1_0980B89DB3FA2964E536F5374AE63298" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_B1E2E6228D808DD6C4BDF5374AE6A7E7" xlink:to="loc_us-gaap_AverageRemainingMaturityOfForeignCurrencyDerivatives1_0980B89DB3FA2964E536F5374AE63298" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetUsefulLife" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetUsefulLife_1480A462F50A68AEC7D0F5374AE626F6" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_B1E2E6228D808DD6C4BDF5374AE6A7E7" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetUsefulLife_1480A462F50A68AEC7D0F5374AE626F6" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PropertyPlantAndEquipmentUsefulLife" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentUsefulLife_73BBC05113C457AAB19CF5374AE67FDD" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_B1E2E6228D808DD6C4BDF5374AE6A7E7" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentUsefulLife_73BBC05113C457AAB19CF5374AE67FDD" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_Depreciation" xlink:label="loc_us-gaap_Depreciation_ED8397524850A80F82C7F5374AE682C8" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_B1E2E6228D808DD6C4BDF5374AE6A7E7" xlink:to="loc_us-gaap_Depreciation_ED8397524850A80F82C7F5374AE682C8" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_LeaseAndRentalExpense" xlink:label="loc_us-gaap_LeaseAndRentalExpense_21D9189AA4E57294C3A4F5374AE6C68B" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_B1E2E6228D808DD6C4BDF5374AE6A7E7" xlink:to="loc_us-gaap_LeaseAndRentalExpense_21D9189AA4E57294C3A4F5374AE6C68B" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_SalesRevenueGoodsNet" xlink:label="loc_us-gaap_SalesRevenueGoodsNet_40D249FE1DAB4EF9255FF5374AE64A83" xlink:type="locator" />
    <presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_B1E2E6228D808DD6C4BDF5374AE6A7E7" xlink:to="loc_us-gaap_SalesRevenueGoodsNet_40D249FE1DAB4EF9255FF5374AE64A83" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OtherSalesRevenueNet" xlink:label="loc_us-gaap_OtherSalesRevenueNet_9E8736B05997E786B3B1F5374AE74A0C" xlink:type="locator" />
    <presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_B1E2E6228D808DD6C4BDF5374AE6A7E7" xlink:to="loc_us-gaap_OtherSalesRevenueNet_9E8736B05997E786B3B1F5374AE74A0C" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_Revenues" xlink:label="loc_us-gaap_Revenues_977BF8573F43ABFA75ACF5374AE7A350" xlink:type="locator" />
    <presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_B1E2E6228D808DD6C4BDF5374AE6A7E7" xlink:to="loc_us-gaap_Revenues_977BF8573F43ABFA75ACF5374AE7A350" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.lilly.com/role/SummaryOfSignificantAccountingPoliciesPolicies" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AccountingPoliciesAbstract" xlink:label="loc_us-gaap_AccountingPoliciesAbstract_CAD612B87D0BB78F1FDBFC036F1FFAA0" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CashAndCashEquivalentsPolicyTextBlock" xlink:label="loc_us-gaap_CashAndCashEquivalentsPolicyTextBlock_732D9AEC369B13BC4E4DFC036F1FED14" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_CAD612B87D0BB78F1FDBFC036F1FFAA0" xlink:to="loc_us-gaap_CashAndCashEquivalentsPolicyTextBlock_732D9AEC369B13BC4E4DFC036F1FED14" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_InventoryPolicyTextBlock" xlink:label="loc_us-gaap_InventoryPolicyTextBlock_8070D9F4022315D3BAD8FC036F1F44EB" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_CAD612B87D0BB78F1FDBFC036F1FFAA0" xlink:to="loc_us-gaap_InventoryPolicyTextBlock_8070D9F4022315D3BAD8FC036F1F44EB" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_InvestmentPolicyTextBlock" xlink:label="loc_us-gaap_InvestmentPolicyTextBlock_DA82EF25C374AE0D6C92FC036F1FB993" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_CAD612B87D0BB78F1FDBFC036F1FFAA0" xlink:to="loc_us-gaap_InvestmentPolicyTextBlock_DA82EF25C374AE0D6C92FC036F1FB993" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DerivativesPolicyTextBlock" xlink:label="loc_us-gaap_DerivativesPolicyTextBlock_D5FDD890BC93F63B09D0FC036F1F6CCA" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_CAD612B87D0BB78F1FDBFC036F1FFAA0" xlink:to="loc_us-gaap_DerivativesPolicyTextBlock_D5FDD890BC93F63B09D0FC036F1F6CCA" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_GoodwillAndIntangibleAssetsPolicyTextBlock" xlink:label="loc_us-gaap_GoodwillAndIntangibleAssetsPolicyTextBlock_69B541256CAEDD99B9D4FC036F1F6E64" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_CAD612B87D0BB78F1FDBFC036F1FFAA0" xlink:to="loc_us-gaap_GoodwillAndIntangibleAssetsPolicyTextBlock_69B541256CAEDD99B9D4FC036F1F6E64" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PropertyPlantAndEquipmentPolicyTextBlock" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentPolicyTextBlock_87E99F6A72D653BBCBE3FC036F1F42D9" xlink:type="locator" />
    <presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_CAD612B87D0BB78F1FDBFC036F1FFAA0" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentPolicyTextBlock_87E99F6A72D653BBCBE3FC036F1F42D9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CommitmentsAndContingenciesPolicyTextBlock" xlink:label="loc_us-gaap_CommitmentsAndContingenciesPolicyTextBlock_4DD03D5D16BA21B372EEFC036F1F8D05" xlink:type="locator" />
    <presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_CAD612B87D0BB78F1FDBFC036F1FFAA0" xlink:to="loc_us-gaap_CommitmentsAndContingenciesPolicyTextBlock_4DD03D5D16BA21B372EEFC036F1F8D05" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_RevenueRecognitionPolicyTextBlock" xlink:label="loc_us-gaap_RevenueRecognitionPolicyTextBlock_AEF9955BE266020445EBFC036F1FEECA" xlink:type="locator" />
    <presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_CAD612B87D0BB78F1FDBFC036F1FFAA0" xlink:to="loc_us-gaap_RevenueRecognitionPolicyTextBlock_AEF9955BE266020445EBFC036F1FEECA" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ResearchAndDevelopmentExpensePolicy" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpensePolicy_BBA169C010E148247483FC036F1F7F57" xlink:type="locator" />
    <presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_CAD612B87D0BB78F1FDBFC036F1FFAA0" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpensePolicy_BBA169C010E148247483FC036F1F7F57" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_IncomeTaxPolicyTextBlock" xlink:label="loc_us-gaap_IncomeTaxPolicyTextBlock_BA6354906BF2E63F251AFC036F1F67FE" xlink:type="locator" />
    <presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_CAD612B87D0BB78F1FDBFC036F1FFAA0" xlink:to="loc_us-gaap_IncomeTaxPolicyTextBlock_BA6354906BF2E63F251AFC036F1F67FE" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_EarningsPerSharePolicyTextBlock" xlink:label="loc_us-gaap_EarningsPerSharePolicyTextBlock_AC5CABFE410D6BA7453FFC036F1F3CD6" xlink:type="locator" />
    <presentationArc order="11" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_CAD612B87D0BB78F1FDBFC036F1FFAA0" xlink:to="loc_us-gaap_EarningsPerSharePolicyTextBlock_AC5CABFE410D6BA7453FFC036F1F3CD6" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ShareBasedCompensationOptionAndIncentivePlansPolicy" xlink:label="loc_us-gaap_ShareBasedCompensationOptionAndIncentivePlansPolicy_4E8022BFA8AF6E6E7843FC036F1FF294" xlink:type="locator" />
    <presentationArc order="12" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_CAD612B87D0BB78F1FDBFC036F1FFAA0" xlink:to="loc_us-gaap_ShareBasedCompensationOptionAndIncentivePlansPolicy_4E8022BFA8AF6E6E7843FC036F1FF294" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ForeignCurrencyTransactionsAndTranslationsPolicyTextBlock" xlink:label="loc_us-gaap_ForeignCurrencyTransactionsAndTranslationsPolicyTextBlock_D7AC830C9F9AB96FC042FC036F1F495F" xlink:type="locator" />
    <presentationArc order="13" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_CAD612B87D0BB78F1FDBFC036F1FFAA0" xlink:to="loc_us-gaap_ForeignCurrencyTransactionsAndTranslationsPolicyTextBlock_D7AC830C9F9AB96FC042FC036F1F495F" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.lilly.com/role/SummaryOfSignificantAccountingPoliciesTables" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AccountingPoliciesAbstract" xlink:label="loc_us-gaap_AccountingPoliciesAbstract_86F29F4AD63C67EBE1F9FC036E43FBE9" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_InventoryDisclosureTextBlock" xlink:label="loc_us-gaap_InventoryDisclosureTextBlock_6190263FC3458465DD43FC036E43B6C7" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_86F29F4AD63C67EBE1F9FC036E43FBE9" xlink:to="loc_us-gaap_InventoryDisclosureTextBlock_6190263FC3458465DD43FC036E43B6C7" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PropertyPlantAndEquipmentDisclosureTextBlock" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentDisclosureTextBlock_2CF17A0940D982F59457FC036E43C328" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_86F29F4AD63C67EBE1F9FC036E43FBE9" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentDisclosureTextBlock_2CF17A0940D982F59457FC036E43C328" xlink:type="arc" />
  </presentationLink>
</linkbase>
