<?xml version="1.0" encoding="US-ASCII"?>
<!--XBRL Document Created with Wdesk from Workiva-->
<!-- -->
<linkbase xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd" xmlns="http://www.xbrl.org/2003/linkbase" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
  <roleRef roleURI="http://www.lilly.com/role/Acquisitions" xlink:href="lly-20160630.xsd#Acquisitions" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/AcquisitionsAcquistionsTables" xlink:href="lly-20160630.xsd#AcquisitionsAcquistionsTables" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/AcquisitionsDetails" xlink:href="lly-20160630.xsd#AcquisitionsDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/AssetImpairmentRestructuringAndOtherSpecialChargesAssetImpairmentRestructuringAndOtherSpecialCharges" xlink:href="lly-20160630.xsd#AssetImpairmentRestructuringAndOtherSpecialChargesAssetImpairmentRestructuringAndOtherSpecialCharges" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/AssetImpairmentRestructuringAndOtherSpecialChargesAssetImpairmentRestructuringAndOtherSpecialChargesTables" xlink:href="lly-20160630.xsd#AssetImpairmentRestructuringAndOtherSpecialChargesAssetImpairmentRestructuringAndOtherSpecialChargesTables" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/AssetImpairmentRestructuringAndOtherSpecialChargesDetails" xlink:href="lly-20160630.xsd#AssetImpairmentRestructuringAndOtherSpecialChargesDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/BasisOfPresentation" xlink:href="lly-20160630.xsd#BasisOfPresentation" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/CollaborationsAndOtherArrangements" xlink:href="lly-20160630.xsd#CollaborationsAndOtherArrangements" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/CollaborationsAndOtherArrangementsDetails" xlink:href="lly-20160630.xsd#CollaborationsAndOtherArrangementsDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/CollaborationsAndOtherArrangementsTables" xlink:href="lly-20160630.xsd#CollaborationsAndOtherArrangementsTables" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/ConsolidatedCondensedBalanceSheets" xlink:href="lly-20160630.xsd#ConsolidatedCondensedBalanceSheets" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/ConsolidatedCondensedBalanceSheetsParenthetical" xlink:href="lly-20160630.xsd#ConsolidatedCondensedBalanceSheetsParenthetical" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/ConsolidatedCondensedStatementsOfCashFlows" xlink:href="lly-20160630.xsd#ConsolidatedCondensedStatementsOfCashFlows" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/ConsolidatedCondensedStatementsOfComprehensiveIncome" xlink:href="lly-20160630.xsd#ConsolidatedCondensedStatementsOfComprehensiveIncome" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/ConsolidatedCondensedStatementsOfOperations" xlink:href="lly-20160630.xsd#ConsolidatedCondensedStatementsOfOperations" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/Contingencies" xlink:href="lly-20160630.xsd#Contingencies" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/ContingenciesDetails" xlink:href="lly-20160630.xsd#ContingenciesDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/DocumentAndEntityInformation" xlink:href="lly-20160630.xsd#DocumentAndEntityInformation" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/FinancialInstruments" xlink:href="lly-20160630.xsd#FinancialInstruments" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/FinancialInstrumentsDetails" xlink:href="lly-20160630.xsd#FinancialInstrumentsDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/FinancialInstrumentsPolicies" xlink:href="lly-20160630.xsd#FinancialInstrumentsPolicies" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/FinancialInstrumentsTables" xlink:href="lly-20160630.xsd#FinancialInstrumentsTables" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/ImplementationOfNewFinancialAccountingPronouncements" xlink:href="lly-20160630.xsd#ImplementationOfNewFinancialAccountingPronouncements" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/ImplementationOfNewFinancialAccountingPronouncementsImplementationOfNewAccountingPronouncementsTables" xlink:href="lly-20160630.xsd#ImplementationOfNewFinancialAccountingPronouncementsImplementationOfNewAccountingPronouncementsTables" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/IncomeTaxes" xlink:href="lly-20160630.xsd#IncomeTaxes" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/IncomeTaxesIncomeTaxesDetails" xlink:href="lly-20160630.xsd#IncomeTaxesIncomeTaxesDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/OtherComprehensiveIncomeLossOtherComprehensiveIncomeLossDetails" xlink:href="lly-20160630.xsd#OtherComprehensiveIncomeLossOtherComprehensiveIncomeLossDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/OtherComprehensiveIncomeLossOtherComprehensiveIncomeLossNotes" xlink:href="lly-20160630.xsd#OtherComprehensiveIncomeLossOtherComprehensiveIncomeLossNotes" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/OtherComprehensiveIncomeLossOtherComprehensiveIncomeLossTables" xlink:href="lly-20160630.xsd#OtherComprehensiveIncomeLossOtherComprehensiveIncomeLossTables" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/OtherNetIncomeExpense" xlink:href="lly-20160630.xsd#OtherNetIncomeExpense" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/OtherNetIncomeExpenseDetails" xlink:href="lly-20160630.xsd#OtherNetIncomeExpenseDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/OtherNetIncomeExpenseTables" xlink:href="lly-20160630.xsd#OtherNetIncomeExpenseTables" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/RetirementBenefits" xlink:href="lly-20160630.xsd#RetirementBenefits" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/RetirementBenefitsDetails" xlink:href="lly-20160630.xsd#RetirementBenefitsDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/RetirementBenefitsTables" xlink:href="lly-20160630.xsd#RetirementBenefitsTables" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/SegmentInformation" xlink:href="lly-20160630.xsd#SegmentInformation" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/SegmentInformationDetails" xlink:href="lly-20160630.xsd#SegmentInformationDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/SegmentInformationTables" xlink:href="lly-20160630.xsd#SegmentInformationTables" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/ShareholdersEquity" xlink:href="lly-20160630.xsd#ShareholdersEquity" xlink:type="simple" />
  <roleRef roleURI="http://www.lilly.com/role/ShareholdersEquityDetails" xlink:href="lly-20160630.xsd#ShareholdersEquityDetails" xlink:type="simple" />
  <arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/all" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#all" xlink:type="simple" />
  <arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-default" xlink:type="simple" />
  <arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-domain" xlink:type="simple" />
  <arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/domain-member" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#domain-member" xlink:type="simple" />
  <arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#hypercube-dimension" xlink:type="simple" />
  <definitionLink xlink:role="http://www.lilly.com/role/Acquisitions" xlink:type="extended" />
  <definitionLink xlink:role="http://www.lilly.com/role/AcquisitionsAcquistionsTables" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_BusinessAcquisitionLineItems" xlink:label="loc_us-gaap_BusinessAcquisitionLineItems_BF49C6DF2C6FAE41FD04A5DAF516FBD3" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable" xlink:label="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_5EF42D93AE966B3F4416A5DAF51697F6" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_BF49C6DF2C6FAE41FD04A5DAF516FBD3" xlink:to="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_5EF42D93AE966B3F4416A5DAF51697F6" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_BusinessAcquisitionAxis" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_CCA90537775E94D18A66A5DAF516E506" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_5EF42D93AE966B3F4416A5DAF51697F6" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_CCA90537775E94D18A66A5DAF516E506" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_C257B5BE53FAA7A17AD4A5DAF516F845_default" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_CCA90537775E94D18A66A5DAF516E506" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_C257B5BE53FAA7A17AD4A5DAF516F845_default" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_C257B5BE53FAA7A17AD4A5DAF516F845" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_CCA90537775E94D18A66A5DAF516E506" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_C257B5BE53FAA7A17AD4A5DAF516F845" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_NovartisAnimalHealthMember" xlink:label="loc_lly_NovartisAnimalHealthMember_A8DF8EAFA87BD22D4B0EA5DAF5167396" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_C257B5BE53FAA7A17AD4A5DAF516F845" xlink:to="loc_lly_NovartisAnimalHealthMember_A8DF8EAFA87BD22D4B0EA5DAF5167396" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_LohmannAnimalHealthMember" xlink:label="loc_lly_LohmannAnimalHealthMember_47F16108501E06CE6668A5DAF51672B3" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_C257B5BE53FAA7A17AD4A5DAF516F845" xlink:to="loc_lly_LohmannAnimalHealthMember_47F16108501E06CE6668A5DAF51672B3" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_IncomeStatementLocationAxis" xlink:label="loc_us-gaap_IncomeStatementLocationAxis_794FD631513008087B6CA5DAF5169A7C" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_5EF42D93AE966B3F4416A5DAF51697F6" xlink:to="loc_us-gaap_IncomeStatementLocationAxis_794FD631513008087B6CA5DAF5169A7C" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_IncomeStatementLocationDomain" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_C1063B14FBE1858E6506A5DAF5166D59_default" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_794FD631513008087B6CA5DAF5169A7C" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_C1063B14FBE1858E6506A5DAF5166D59_default" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_IncomeStatementLocationDomain" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_C1063B14FBE1858E6506A5DAF5166D59" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_794FD631513008087B6CA5DAF5169A7C" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_C1063B14FBE1858E6506A5DAF5166D59" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_StatementClassOfStockAxis" xlink:label="loc_us-gaap_StatementClassOfStockAxis_55CA4DFFF50BE32FFFBBA5DAF5165689" xlink:type="locator" />
    <definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_5EF42D93AE966B3F4416A5DAF51697F6" xlink:to="loc_us-gaap_StatementClassOfStockAxis_55CA4DFFF50BE32FFFBBA5DAF5165689" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ClassOfStockDomain" xlink:label="loc_us-gaap_ClassOfStockDomain_62FCB7FE1CE3BC71BBCBA5DAF516C785_default" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementClassOfStockAxis_55CA4DFFF50BE32FFFBBA5DAF5165689" xlink:to="loc_us-gaap_ClassOfStockDomain_62FCB7FE1CE3BC71BBCBA5DAF516C785_default" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ClassOfStockDomain" xlink:label="loc_us-gaap_ClassOfStockDomain_62FCB7FE1CE3BC71BBCBA5DAF516C785" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementClassOfStockAxis_55CA4DFFF50BE32FFFBBA5DAF5165689" xlink:to="loc_us-gaap_ClassOfStockDomain_62FCB7FE1CE3BC71BBCBA5DAF516C785" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ScheduleOfRecognizedIdentifiedAssetsAcquiredAndLiabilitiesAssumedTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfRecognizedIdentifiedAssetsAcquiredAndLiabilitiesAssumedTableTextBlock_70D47C38A9B52A66ED95A5DAF5167DAF" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_BF49C6DF2C6FAE41FD04A5DAF516FBD3" xlink:to="loc_us-gaap_ScheduleOfRecognizedIdentifiedAssetsAcquiredAndLiabilitiesAssumedTableTextBlock_70D47C38A9B52A66ED95A5DAF5167DAF" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ScheduleOfResearchAndDevelopmentAssetsAcquiredOtherThanThroughBusinessCombinationTextBlock" xlink:label="loc_us-gaap_ScheduleOfResearchAndDevelopmentAssetsAcquiredOtherThanThroughBusinessCombinationTextBlock_172C903261814A8B2C25A5DAF518D5CD" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_BF49C6DF2C6FAE41FD04A5DAF516FBD3" xlink:to="loc_us-gaap_ScheduleOfResearchAndDevelopmentAssetsAcquiredOtherThanThroughBusinessCombinationTextBlock_172C903261814A8B2C25A5DAF518D5CD" xlink:type="arc" />
  </definitionLink>
  <definitionLink xlink:role="http://www.lilly.com/role/AcquisitionsDetails" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_613AF35BDD4AC39C758C325BEF426531" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable" xlink:label="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_00787F3B880E7CDBEE1C325BEF3B979F" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_613AF35BDD4AC39C758C325BEF426531" xlink:to="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_00787F3B880E7CDBEE1C325BEF3B979F" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_StatementBusinessSegmentsAxis" xlink:label="loc_us-gaap_StatementBusinessSegmentsAxis_33F15BDC56C20BEE9484325BEF3BD54B" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_00787F3B880E7CDBEE1C325BEF3B979F" xlink:to="loc_us-gaap_StatementBusinessSegmentsAxis_33F15BDC56C20BEE9484325BEF3BD54B" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SegmentDomain" xlink:label="loc_us-gaap_SegmentDomain_C049F06FE26C0019F363325BEF3B9962_default" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_33F15BDC56C20BEE9484325BEF3BD54B" xlink:to="loc_us-gaap_SegmentDomain_C049F06FE26C0019F363325BEF3B9962_default" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SegmentDomain" xlink:label="loc_us-gaap_SegmentDomain_C049F06FE26C0019F363325BEF3B9962" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_33F15BDC56C20BEE9484325BEF3BD54B" xlink:to="loc_us-gaap_SegmentDomain_C049F06FE26C0019F363325BEF3B9962" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CorporateNonSegmentMember" xlink:label="loc_us-gaap_CorporateNonSegmentMember_17DB917E35032B775CFF325BEF3B2BA9" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_C049F06FE26C0019F363325BEF3B9962" xlink:to="loc_us-gaap_CorporateNonSegmentMember_17DB917E35032B775CFF325BEF3B2BA9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_NonrecurringAdjustmentAxis" xlink:label="loc_us-gaap_NonrecurringAdjustmentAxis_C14BAB8F4B10FECAA5B9325BEF3BEAD6" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_00787F3B880E7CDBEE1C325BEF3B979F" xlink:to="loc_us-gaap_NonrecurringAdjustmentAxis_C14BAB8F4B10FECAA5B9325BEF3BEAD6" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_NonrecurringAdjustmentDomain" xlink:label="loc_us-gaap_NonrecurringAdjustmentDomain_99DE596680607600A42F325BEF3B4775_default" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_NonrecurringAdjustmentAxis_C14BAB8F4B10FECAA5B9325BEF3BEAD6" xlink:to="loc_us-gaap_NonrecurringAdjustmentDomain_99DE596680607600A42F325BEF3B4775_default" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_NonrecurringAdjustmentDomain" xlink:label="loc_us-gaap_NonrecurringAdjustmentDomain_99DE596680607600A42F325BEF3B4775" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_NonrecurringAdjustmentAxis_C14BAB8F4B10FECAA5B9325BEF3BEAD6" xlink:to="loc_us-gaap_NonrecurringAdjustmentDomain_99DE596680607600A42F325BEF3B4775" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_AmortizationofFairValueAdjustedIntangibleAssetsMember" xlink:label="loc_lly_AmortizationofFairValueAdjustedIntangibleAssetsMember_C5F6AB5A1B7095FE61EC325BEF3B470C" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NonrecurringAdjustmentDomain_99DE596680607600A42F325BEF3B4775" xlink:to="loc_lly_AmortizationofFairValueAdjustedIntangibleAssetsMember_C5F6AB5A1B7095FE61EC325BEF3B470C" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FairValueAdjustmentToInventoryMember" xlink:label="loc_us-gaap_FairValueAdjustmentToInventoryMember_E8C3BA01257E641FAB9D325BEF3B153C" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NonrecurringAdjustmentDomain_99DE596680607600A42F325BEF3B4775" xlink:to="loc_us-gaap_FairValueAdjustmentToInventoryMember_E8C3BA01257E641FAB9D325BEF3B153C" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AcquisitionRelatedCostsMember" xlink:label="loc_us-gaap_AcquisitionRelatedCostsMember_A50274659927A44E93CD325BEF3B144A" xlink:type="locator" />
    <definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NonrecurringAdjustmentDomain_99DE596680607600A42F325BEF3B4775" xlink:to="loc_us-gaap_AcquisitionRelatedCostsMember_A50274659927A44E93CD325BEF3B144A" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_MajorPropertyClassAxis" xlink:label="loc_us-gaap_MajorPropertyClassAxis_ED256F7E82ECDF1996B2325BEF3B95B1" xlink:type="locator" />
    <definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_00787F3B880E7CDBEE1C325BEF3B979F" xlink:to="loc_us-gaap_MajorPropertyClassAxis_ED256F7E82ECDF1996B2325BEF3B95B1" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_MajorPropertyClassDomain" xlink:label="loc_us-gaap_MajorPropertyClassDomain_22AB82C6C1924B55E78B325BEF3BF62E_default" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_MajorPropertyClassAxis_ED256F7E82ECDF1996B2325BEF3B95B1" xlink:to="loc_us-gaap_MajorPropertyClassDomain_22AB82C6C1924B55E78B325BEF3BF62E_default" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_MajorPropertyClassDomain" xlink:label="loc_us-gaap_MajorPropertyClassDomain_22AB82C6C1924B55E78B325BEF3BF62E" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_MajorPropertyClassAxis_ED256F7E82ECDF1996B2325BEF3B95B1" xlink:to="loc_us-gaap_MajorPropertyClassDomain_22AB82C6C1924B55E78B325BEF3BF62E" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DiscontinuedOperationsHeldForSaleOrDisposedOfBySaleMember" xlink:label="loc_us-gaap_DiscontinuedOperationsHeldForSaleOrDisposedOfBySaleMember_D3CAED530A8684A817ED325BEF3B76FB" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_MajorPropertyClassDomain_22AB82C6C1924B55E78B325BEF3BF62E" xlink:to="loc_us-gaap_DiscontinuedOperationsHeldForSaleOrDisposedOfBySaleMember_D3CAED530A8684A817ED325BEF3B76FB" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_StatementGeographicalAxis" xlink:label="loc_us-gaap_StatementGeographicalAxis_AE7A58CEF9A7FFD8EDBA325BEF3B7270" xlink:type="locator" />
    <definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_00787F3B880E7CDBEE1C325BEF3B979F" xlink:to="loc_us-gaap_StatementGeographicalAxis_AE7A58CEF9A7FFD8EDBA325BEF3B7270" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SegmentGeographicalDomain" xlink:label="loc_us-gaap_SegmentGeographicalDomain_C5D72EBBB872C776785D325BEF3BD024_default" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementGeographicalAxis_AE7A58CEF9A7FFD8EDBA325BEF3B7270" xlink:to="loc_us-gaap_SegmentGeographicalDomain_C5D72EBBB872C776785D325BEF3BD024_default" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SegmentGeographicalDomain" xlink:label="loc_us-gaap_SegmentGeographicalDomain_C5D72EBBB872C776785D325BEF3BD024" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementGeographicalAxis_AE7A58CEF9A7FFD8EDBA325BEF3B7270" xlink:to="loc_us-gaap_SegmentGeographicalDomain_C5D72EBBB872C776785D325BEF3BD024" xlink:type="arc" />
    <loc xlink:href="http://xbrl.sec.gov/country/2016/country-2016-01-31.xsd#country_US" xlink:label="loc_country_US_25BC1C92BC5A1D24DB1D325BEF3C2D99" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentGeographicalDomain_C5D72EBBB872C776785D325BEF3BD024" xlink:to="loc_country_US_25BC1C92BC5A1D24DB1D325BEF3C2D99" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SubsequentEventTypeAxis" xlink:label="loc_us-gaap_SubsequentEventTypeAxis_79D5C041FD6EBA592AA4325BEF3C3B96" xlink:type="locator" />
    <definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_00787F3B880E7CDBEE1C325BEF3B979F" xlink:to="loc_us-gaap_SubsequentEventTypeAxis_79D5C041FD6EBA592AA4325BEF3C3B96" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SubsequentEventTypeDomain" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_14AA5363557D21C8B1E5325BEF3C2AB9_default" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_79D5C041FD6EBA592AA4325BEF3C3B96" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_14AA5363557D21C8B1E5325BEF3C2AB9_default" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SubsequentEventTypeDomain" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_14AA5363557D21C8B1E5325BEF3C2AB9" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_79D5C041FD6EBA592AA4325BEF3C3B96" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_14AA5363557D21C8B1E5325BEF3C2AB9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SubsequentEventMember" xlink:label="loc_us-gaap_SubsequentEventMember_18159A1BB18DF7451DD9325BEF3C1873" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsequentEventTypeDomain_14AA5363557D21C8B1E5325BEF3C2AB9" xlink:to="loc_us-gaap_SubsequentEventMember_18159A1BB18DF7451DD9325BEF3C1873" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ProductOrServiceAxis" xlink:label="loc_us-gaap_ProductOrServiceAxis_9C6C968E91E0CB9FCE94325BEF41D398" xlink:type="locator" />
    <definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_00787F3B880E7CDBEE1C325BEF3B979F" xlink:to="loc_us-gaap_ProductOrServiceAxis_9C6C968E91E0CB9FCE94325BEF41D398" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ProductsAndServicesDomain" xlink:label="loc_us-gaap_ProductsAndServicesDomain_ECEE9EC2C7E69CCCAC82325BEF419083_default" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ProductOrServiceAxis_9C6C968E91E0CB9FCE94325BEF41D398" xlink:to="loc_us-gaap_ProductsAndServicesDomain_ECEE9EC2C7E69CCCAC82325BEF419083_default" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ProductsAndServicesDomain" xlink:label="loc_us-gaap_ProductsAndServicesDomain_ECEE9EC2C7E69CCCAC82325BEF419083" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ProductOrServiceAxis_9C6C968E91E0CB9FCE94325BEF41D398" xlink:to="loc_us-gaap_ProductsAndServicesDomain_ECEE9EC2C7E69CCCAC82325BEF419083" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_U.S.SentinelProductLineMember" xlink:label="loc_lly_U.S.SentinelProductLineMember_865D451CDDCDE0A7FC43325BEF419E70" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ProductsAndServicesDomain_ECEE9EC2C7E69CCCAC82325BEF419083" xlink:to="loc_lly_U.S.SentinelProductLineMember_865D451CDDCDE0A7FC43325BEF419E70" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_TanezumabMember" xlink:label="loc_lly_TanezumabMember_C3870C4B37E8EA6954AE325BEF41EC6A" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ProductsAndServicesDomain_ECEE9EC2C7E69CCCAC82325BEF419083" xlink:to="loc_lly_TanezumabMember_C3870C4B37E8EA6954AE325BEF41EC6A" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_BiCompoundsMember" xlink:label="loc_lly_BiCompoundsMember_56B52A3966AD539B0AD0325BEF4122A0" xlink:type="locator" />
    <definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ProductsAndServicesDomain_ECEE9EC2C7E69CCCAC82325BEF419083" xlink:to="loc_lly_BiCompoundsMember_56B52A3966AD539B0AD0325BEF4122A0" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_D2A718ECAB93079249AA325BEF41FB52" xlink:type="locator" />
    <definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_00787F3B880E7CDBEE1C325BEF3B979F" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_D2A718ECAB93079249AA325BEF41FB52" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_5824EF6F1FB26164112A325BEF41F540_default" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_D2A718ECAB93079249AA325BEF41FB52" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_5824EF6F1FB26164112A325BEF41F540_default" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_5824EF6F1FB26164112A325BEF41F540" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_D2A718ECAB93079249AA325BEF41FB52" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_5824EF6F1FB26164112A325BEF41F540" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DevelopedTechnologyRightsMember" xlink:label="loc_us-gaap_DevelopedTechnologyRightsMember_F92D80249C60959BCFF1325BEF419A21" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_5824EF6F1FB26164112A325BEF41F540" xlink:to="loc_us-gaap_DevelopedTechnologyRightsMember_F92D80249C60959BCFF1325BEF419A21" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CustomerRelationshipsMember" xlink:label="loc_us-gaap_CustomerRelationshipsMember_1531477D627F77C5F6B6325BEF4183F6" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_5824EF6F1FB26164112A325BEF41F540" xlink:to="loc_us-gaap_CustomerRelationshipsMember_1531477D627F77C5F6B6325BEF4183F6" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_BusinessAcquisitionAxis" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_F760367F23A2C9C30F6E325BEF414A44" xlink:type="locator" />
    <definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_00787F3B880E7CDBEE1C325BEF3B979F" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_F760367F23A2C9C30F6E325BEF414A44" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_B3C921C4F1C1FF24E346325BEF41E1B5_default" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_F760367F23A2C9C30F6E325BEF414A44" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_B3C921C4F1C1FF24E346325BEF41E1B5_default" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_B3C921C4F1C1FF24E346325BEF41E1B5" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_F760367F23A2C9C30F6E325BEF414A44" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_B3C921C4F1C1FF24E346325BEF41E1B5" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_NovartisAnimalHealthMember" xlink:label="loc_lly_NovartisAnimalHealthMember_2E01AD547E880A4429B8325BEF421F05" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_B3C921C4F1C1FF24E346325BEF41E1B5" xlink:to="loc_lly_NovartisAnimalHealthMember_2E01AD547E880A4429B8325BEF421F05" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_LohmannAnimalHealthMember" xlink:label="loc_lly_LohmannAnimalHealthMember_20900E5AFB98E4170532325BEF42F599" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_B3C921C4F1C1FF24E346325BEF41E1B5" xlink:to="loc_lly_LohmannAnimalHealthMember_20900E5AFB98E4170532325BEF42F599" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_ImmunocoreLimitedMember" xlink:label="loc_lly_ImmunocoreLimitedMember_6E832882303BF4B55758325BEF427E5F" xlink:type="locator" />
    <definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_B3C921C4F1C1FF24E346325BEF41E1B5" xlink:to="loc_lly_ImmunocoreLimitedMember_6E832882303BF4B55758325BEF427E5F" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_AstraZenecaMember" xlink:label="loc_lly_AstraZenecaMember_ED71A5D13F488025A9E2325BEF42BF6C" xlink:type="locator" />
    <definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_B3C921C4F1C1FF24E346325BEF41E1B5" xlink:to="loc_lly_AstraZenecaMember_ED71A5D13F488025A9E2325BEF42BF6C" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_InnoventBiologicsInc.Member" xlink:label="loc_lly_InnoventBiologicsInc.Member_A06B54ED381942BAABD0325BEF4246FE" xlink:type="locator" />
    <definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_B3C921C4F1C1FF24E346325BEF41E1B5" xlink:to="loc_lly_InnoventBiologicsInc.Member_A06B54ED381942BAABD0325BEF4246FE" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_HanmiPharmaceuticalCo.Ltd.Member" xlink:label="loc_lly_HanmiPharmaceuticalCo.Ltd.Member_C1B951D1C4B421972EAA325BEF4200FA" xlink:type="locator" />
    <definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_B3C921C4F1C1FF24E346325BEF41E1B5" xlink:to="loc_lly_HanmiPharmaceuticalCo.Ltd.Member_C1B951D1C4B421972EAA325BEF4200FA" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_BioNTechAGMember" xlink:label="loc_lly_BioNTechAGMember_A25837AC88C2A5C9746F325BEF4228CF" xlink:type="locator" />
    <definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_B3C921C4F1C1FF24E346325BEF41E1B5" xlink:to="loc_lly_BioNTechAGMember_A25837AC88C2A5C9746F325BEF4228CF" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedInventory" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedInventory_475E2D6EE4E881B0C8EA325BEF421855" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_613AF35BDD4AC39C758C325BEF426531" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedInventory_475E2D6EE4E881B0C8EA325BEF421855" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AmortizationOfIntangibleAssets" xlink:label="loc_us-gaap_AmortizationOfIntangibleAssets_45CE35D3FD7942A79CEC325BEF4224DE" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_613AF35BDD4AC39C758C325BEF426531" xlink:to="loc_us-gaap_AmortizationOfIntangibleAssets_45CE35D3FD7942A79CEC325BEF4224DE" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssets" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssets_7D5343C173F51449E99E325BEF42920C" xlink:type="locator" />
    <definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_613AF35BDD4AC39C758C325BEF426531" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssets_7D5343C173F51449E99E325BEF42920C" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CostOfGoodsSold" xlink:label="loc_us-gaap_CostOfGoodsSold_EDFB18EE6455F80A6A5C325BEF42AD0F" xlink:type="locator" />
    <definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_613AF35BDD4AC39C758C325BEF426531" xlink:to="loc_us-gaap_CostOfGoodsSold_EDFB18EE6455F80A6A5C325BEF42AD0F" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_InterestExpense" xlink:label="loc_us-gaap_InterestExpense_22F0DF339B32F038EE3D325BEF42370B" xlink:type="locator" />
    <definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_613AF35BDD4AC39C758C325BEF426531" xlink:to="loc_us-gaap_InterestExpense_22F0DF339B32F038EE3D325BEF42370B" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_BusinessCombinationConsiderationTransferred1" xlink:label="loc_us-gaap_BusinessCombinationConsiderationTransferred1_C99ECAB28560973A1992325BEF42E547" xlink:type="locator" />
    <definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_613AF35BDD4AC39C758C325BEF426531" xlink:to="loc_us-gaap_BusinessCombinationConsiderationTransferred1_C99ECAB28560973A1992325BEF42E547" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles_63DC9D8122CA19EB1806325BEF42522B" xlink:type="locator" />
    <definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_613AF35BDD4AC39C758C325BEF426531" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles_63DC9D8122CA19EB1806325BEF42522B" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedFiniteLivedIntangiblesOtherIntangibleAssets" xlink:label="loc_lly_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedFiniteLivedIntangiblesOtherIntangibleAssets_6B37337580A55A50D9B4325BEF423953" xlink:type="locator" />
    <definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_613AF35BDD4AC39C758C325BEF426531" xlink:to="loc_lly_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedFiniteLivedIntangiblesOtherIntangibleAssets_6B37337580A55A50D9B4325BEF423953" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIndefiniteLivedIntangibleAssets" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIndefiniteLivedIntangibleAssets_31733AA7D0D4CD894F90325BEF42AFA0" xlink:type="locator" />
    <definitionArc order="9" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_613AF35BDD4AC39C758C325BEF426531" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIndefiniteLivedIntangibleAssets_31733AA7D0D4CD894F90325BEF42AFA0" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet_3D7081705F89A2E12897325BEF42E8E5" xlink:type="locator" />
    <definitionArc order="10" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_613AF35BDD4AC39C758C325BEF426531" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet_3D7081705F89A2E12897325BEF42E8E5" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_RestrictedCashAndCashEquivalentsNoncurrent" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalentsNoncurrent_1D5E03F0F1AC9B0FC17B325BEF42EDDE" xlink:type="locator" />
    <definitionArc order="11" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_613AF35BDD4AC39C758C325BEF426531" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalentsNoncurrent_1D5E03F0F1AC9B0FC17B325BEF42EDDE" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ProceedsFromDivestitureOfBusinesses" xlink:label="loc_us-gaap_ProceedsFromDivestitureOfBusinesses_C523CFC33A82FB6B7D8A325BEF43F899" xlink:type="locator" />
    <definitionArc order="12" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_613AF35BDD4AC39C758C325BEF426531" xlink:to="loc_us-gaap_ProceedsFromDivestitureOfBusinesses_C523CFC33A82FB6B7D8A325BEF43F899" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AcquiredFiniteLivedIntangibleAssetsWeightedAverageUsefulLife" xlink:label="loc_us-gaap_AcquiredFiniteLivedIntangibleAssetsWeightedAverageUsefulLife_B1ADFC01BA5EFCB91F52325BEF48F087" xlink:type="locator" />
    <definitionArc order="13" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_613AF35BDD4AC39C758C325BEF426531" xlink:to="loc_us-gaap_AcquiredFiniteLivedIntangibleAssetsWeightedAverageUsefulLife_B1ADFC01BA5EFCB91F52325BEF48F087" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_BusinessAcquisitionPurchasePriceAllocationGoodwillExpectedTaxDeductibleAmount" xlink:label="loc_us-gaap_BusinessAcquisitionPurchasePriceAllocationGoodwillExpectedTaxDeductibleAmount_D8370BAE5BC01F0B8A79325BEF482A20" xlink:type="locator" />
    <definitionArc order="14" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_613AF35BDD4AC39C758C325BEF426531" xlink:to="loc_us-gaap_BusinessAcquisitionPurchasePriceAllocationGoodwillExpectedTaxDeductibleAmount_D8370BAE5BC01F0B8A79325BEF482A20" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_BusinessCombinationProFormaInformationRevenueOfAcquireeSinceAcquisitionDateActual" xlink:label="loc_us-gaap_BusinessCombinationProFormaInformationRevenueOfAcquireeSinceAcquisitionDateActual_B10A8F14FCA5C12EC3E8325BEF480887" xlink:type="locator" />
    <definitionArc order="15" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_613AF35BDD4AC39C758C325BEF426531" xlink:to="loc_us-gaap_BusinessCombinationProFormaInformationRevenueOfAcquireeSinceAcquisitionDateActual_B10A8F14FCA5C12EC3E8325BEF480887" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_BusinessAcquisitionsProFormaRevenue" xlink:label="loc_us-gaap_BusinessAcquisitionsProFormaRevenue_5EC49BC3184648093DCD325BEF482AE3" xlink:type="locator" />
    <definitionArc order="16" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_613AF35BDD4AC39C758C325BEF426531" xlink:to="loc_us-gaap_BusinessAcquisitionsProFormaRevenue_5EC49BC3184648093DCD325BEF482AE3" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment_F6EA0C6683E219382770325BEF4847E7" xlink:type="locator" />
    <definitionArc order="17" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_613AF35BDD4AC39C758C325BEF426531" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment_F6EA0C6683E219382770325BEF4847E7" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsOther" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsOther_298686568D0D67194BAA325BEF4841AB" xlink:type="locator" />
    <definitionArc order="18" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_613AF35BDD4AC39C758C325BEF426531" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsOther_298686568D0D67194BAA325BEF4841AB" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilitiesOther" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilitiesOther_C0BCCA8994894BEFBA89325BEF48DFEB" xlink:type="locator" />
    <definitionArc order="19" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_613AF35BDD4AC39C758C325BEF426531" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilitiesOther_C0BCCA8994894BEFBA89325BEF48DFEB" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired" xlink:label="loc_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_A5DF9B30E98FD9524816325BEF4863D2" xlink:type="locator" />
    <definitionArc order="20" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_613AF35BDD4AC39C758C325BEF426531" xlink:to="loc_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_A5DF9B30E98FD9524816325BEF4863D2" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_Goodwill" xlink:label="loc_us-gaap_Goodwill_095FB5CE376E10D9F439325BEF4837AE" xlink:type="locator" />
    <definitionArc order="21" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_613AF35BDD4AC39C758C325BEF426531" xlink:to="loc_us-gaap_Goodwill_095FB5CE376E10D9F439325BEF4837AE" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxLiabilitiesNoncurrent" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxLiabilitiesNoncurrent_1B7FCB759E8B6D084660325BEF48C37E" xlink:type="locator" />
    <definitionArc order="22" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_613AF35BDD4AC39C758C325BEF426531" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxLiabilitiesNoncurrent_1B7FCB759E8B6D084660325BEF48C37E" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities_D0D8102ECEB60D5A2A89325BEF48B0EF" xlink:type="locator" />
    <definitionArc order="23" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_613AF35BDD4AC39C758C325BEF426531" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities_D0D8102ECEB60D5A2A89325BEF48B0EF" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_42DA1E2EEF315645F0EA325BEF4842B1" xlink:type="locator" />
    <definitionArc order="24" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_613AF35BDD4AC39C758C325BEF426531" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_42DA1E2EEF315645F0EA325BEF4842B1" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_AcquiredInProcessResearchAndDevelopment" xlink:label="loc_lly_AcquiredInProcessResearchAndDevelopment_EEA43E3A6B43646C4173325BEF48EC36" xlink:type="locator" />
    <definitionArc order="25" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_613AF35BDD4AC39C758C325BEF426531" xlink:to="loc_lly_AcquiredInProcessResearchAndDevelopment_EEA43E3A6B43646C4173325BEF48EC36" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_PurchasedInProcessResearchAndDevelopment" xlink:label="loc_lly_PurchasedInProcessResearchAndDevelopment_F91396A6DAF2FA06F573325BEF48CCD3" xlink:type="locator" />
    <definitionArc order="26" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_613AF35BDD4AC39C758C325BEF426531" xlink:to="loc_lly_PurchasedInProcessResearchAndDevelopment_F91396A6DAF2FA06F573325BEF48CCD3" xlink:type="arc" />
  </definitionLink>
  <definitionLink xlink:role="http://www.lilly.com/role/AssetImpairmentRestructuringAndOtherSpecialChargesAssetImpairmentRestructuringAndOtherSpecialCharges" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_RestructuringCostAndReserveLineItems" xlink:label="loc_us-gaap_RestructuringCostAndReserveLineItems_4135C51312150BDA8039A5DAF4F05F8A" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ScheduleOfRestructuringAndRelatedCostsTable" xlink:label="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_D02D29A6E8AFB22E59C4A5DAF4F0299B" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_4135C51312150BDA8039A5DAF4F05F8A" xlink:to="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_D02D29A6E8AFB22E59C4A5DAF4F0299B" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_RestructuringCostAndReserveAxis" xlink:label="loc_us-gaap_RestructuringCostAndReserveAxis_EFA8B41B1750A5609250A5DAF4F0A87A" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_D02D29A6E8AFB22E59C4A5DAF4F0299B" xlink:to="loc_us-gaap_RestructuringCostAndReserveAxis_EFA8B41B1750A5609250A5DAF4F0A87A" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_TypeOfRestructuringDomain" xlink:label="loc_us-gaap_TypeOfRestructuringDomain_A724E49428ED02FCEEF4A5DAF4F041D6_default" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RestructuringCostAndReserveAxis_EFA8B41B1750A5609250A5DAF4F0A87A" xlink:to="loc_us-gaap_TypeOfRestructuringDomain_A724E49428ED02FCEEF4A5DAF4F041D6_default" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_TypeOfRestructuringDomain" xlink:label="loc_us-gaap_TypeOfRestructuringDomain_A724E49428ED02FCEEF4A5DAF4F041D6" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RestructuringCostAndReserveAxis_EFA8B41B1750A5609250A5DAF4F0A87A" xlink:to="loc_us-gaap_TypeOfRestructuringDomain_A724E49428ED02FCEEF4A5DAF4F041D6" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_RestructuringImpairmentAndOtherActivitiesDisclosureTextBlock" xlink:label="loc_us-gaap_RestructuringImpairmentAndOtherActivitiesDisclosureTextBlock_9A4A30B98EC541D50A03A5DAF4F07A99" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_4135C51312150BDA8039A5DAF4F05F8A" xlink:to="loc_us-gaap_RestructuringImpairmentAndOtherActivitiesDisclosureTextBlock_9A4A30B98EC541D50A03A5DAF4F07A99" xlink:type="arc" />
  </definitionLink>
  <definitionLink xlink:role="http://www.lilly.com/role/AssetImpairmentRestructuringAndOtherSpecialChargesAssetImpairmentRestructuringAndOtherSpecialChargesTables" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_RestructuringCostAndReserveLineItems" xlink:label="loc_us-gaap_RestructuringCostAndReserveLineItems_E206104451F776552218A5DAF4F613FC" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ScheduleOfRestructuringAndRelatedCostsTable" xlink:label="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_329EB1EA1D3AFBF703BBA5DAF4F6368B" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_E206104451F776552218A5DAF4F613FC" xlink:to="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_329EB1EA1D3AFBF703BBA5DAF4F6368B" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_RestructuringCostAndReserveAxis" xlink:label="loc_us-gaap_RestructuringCostAndReserveAxis_3775C6F5A4779C0A62ACA5DAF4F60576" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_329EB1EA1D3AFBF703BBA5DAF4F6368B" xlink:to="loc_us-gaap_RestructuringCostAndReserveAxis_3775C6F5A4779C0A62ACA5DAF4F60576" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_TypeOfRestructuringDomain" xlink:label="loc_us-gaap_TypeOfRestructuringDomain_C7C8995ACE10BD215C93A5DAF4F6FF30_default" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RestructuringCostAndReserveAxis_3775C6F5A4779C0A62ACA5DAF4F60576" xlink:to="loc_us-gaap_TypeOfRestructuringDomain_C7C8995ACE10BD215C93A5DAF4F6FF30_default" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_TypeOfRestructuringDomain" xlink:label="loc_us-gaap_TypeOfRestructuringDomain_C7C8995ACE10BD215C93A5DAF4F6FF30" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RestructuringCostAndReserveAxis_3775C6F5A4779C0A62ACA5DAF4F60576" xlink:to="loc_us-gaap_TypeOfRestructuringDomain_C7C8995ACE10BD215C93A5DAF4F6FF30" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ScheduleOfRestructuringAndRelatedCostsTextBlock" xlink:label="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTextBlock_77D37135C4105F2F3D6AA5DAF4F69AD8" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_E206104451F776552218A5DAF4F613FC" xlink:to="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTextBlock_77D37135C4105F2F3D6AA5DAF4F69AD8" xlink:type="arc" />
  </definitionLink>
  <definitionLink xlink:role="http://www.lilly.com/role/AssetImpairmentRestructuringAndOtherSpecialChargesDetails" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_RestructuringCostAndReserveLineItems" xlink:label="loc_us-gaap_RestructuringCostAndReserveLineItems_5234F47EE238B2273AD7325BEEA23DCA" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ScheduleOfRestructuringAndRelatedCostsTable" xlink:label="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_3E7D7AFB7EBE226E5A67325BEE9B0BD2" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_5234F47EE238B2273AD7325BEEA23DCA" xlink:to="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_3E7D7AFB7EBE226E5A67325BEE9B0BD2" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_StatementGeographicalAxis" xlink:label="loc_us-gaap_StatementGeographicalAxis_F12801B0FE68521969DA325BEE9CFB5C" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_3E7D7AFB7EBE226E5A67325BEE9B0BD2" xlink:to="loc_us-gaap_StatementGeographicalAxis_F12801B0FE68521969DA325BEE9CFB5C" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SegmentGeographicalDomain" xlink:label="loc_us-gaap_SegmentGeographicalDomain_8F427C012CEEAA015859325BEE9CD703_default" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementGeographicalAxis_F12801B0FE68521969DA325BEE9CFB5C" xlink:to="loc_us-gaap_SegmentGeographicalDomain_8F427C012CEEAA015859325BEE9CD703_default" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SegmentGeographicalDomain" xlink:label="loc_us-gaap_SegmentGeographicalDomain_8F427C012CEEAA015859325BEE9CD703" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementGeographicalAxis_F12801B0FE68521969DA325BEE9CFB5C" xlink:to="loc_us-gaap_SegmentGeographicalDomain_8F427C012CEEAA015859325BEE9CD703" xlink:type="arc" />
    <loc xlink:href="http://xbrl.sec.gov/country/2016/country-2016-01-31.xsd#country_IE" xlink:label="loc_country_IE_4DE7193E39F30C93D19B325BEE9CAD85" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentGeographicalDomain_8F427C012CEEAA015859325BEE9CD703" xlink:to="loc_country_IE_4DE7193E39F30C93D19B325BEE9CAD85" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_StatementBusinessSegmentsAxis" xlink:label="loc_us-gaap_StatementBusinessSegmentsAxis_5FE7C6BFB855CCB296FF325BEEA1E859" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_3E7D7AFB7EBE226E5A67325BEE9B0BD2" xlink:to="loc_us-gaap_StatementBusinessSegmentsAxis_5FE7C6BFB855CCB296FF325BEEA1E859" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SegmentDomain" xlink:label="loc_us-gaap_SegmentDomain_9D4E13084701C439DB2E325BEEA1BF46_default" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_5FE7C6BFB855CCB296FF325BEEA1E859" xlink:to="loc_us-gaap_SegmentDomain_9D4E13084701C439DB2E325BEEA1BF46_default" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SegmentDomain" xlink:label="loc_us-gaap_SegmentDomain_9D4E13084701C439DB2E325BEEA1BF46" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_5FE7C6BFB855CCB296FF325BEEA1E859" xlink:to="loc_us-gaap_SegmentDomain_9D4E13084701C439DB2E325BEEA1BF46" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_HumanPharmaceuticalProductsMember" xlink:label="loc_lly_HumanPharmaceuticalProductsMember_F18DB70DF7C4CE033B61325BEEA18598" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_9D4E13084701C439DB2E325BEEA1BF46" xlink:to="loc_lly_HumanPharmaceuticalProductsMember_F18DB70DF7C4CE033B61325BEEA18598" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_AnimalHealthMember" xlink:label="loc_lly_AnimalHealthMember_1144C7673F34F1CBE302325BEEA26D60" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_9D4E13084701C439DB2E325BEEA1BF46" xlink:to="loc_lly_AnimalHealthMember_1144C7673F34F1CBE302325BEEA26D60" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_RestructuringCostAndReserveAxis" xlink:label="loc_us-gaap_RestructuringCostAndReserveAxis_FAF7A1233F3FF4A79BE2325BEEA2C2BC" xlink:type="locator" />
    <definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_3E7D7AFB7EBE226E5A67325BEE9B0BD2" xlink:to="loc_us-gaap_RestructuringCostAndReserveAxis_FAF7A1233F3FF4A79BE2325BEEA2C2BC" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_TypeOfRestructuringDomain" xlink:label="loc_us-gaap_TypeOfRestructuringDomain_264A7D96C101CAC226B8325BEEA232A1_default" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RestructuringCostAndReserveAxis_FAF7A1233F3FF4A79BE2325BEEA2C2BC" xlink:to="loc_us-gaap_TypeOfRestructuringDomain_264A7D96C101CAC226B8325BEEA232A1_default" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_TypeOfRestructuringDomain" xlink:label="loc_us-gaap_TypeOfRestructuringDomain_264A7D96C101CAC226B8325BEEA232A1" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RestructuringCostAndReserveAxis_FAF7A1233F3FF4A79BE2325BEEA2C2BC" xlink:to="loc_us-gaap_TypeOfRestructuringDomain_264A7D96C101CAC226B8325BEEA232A1" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SeveranceCosts1" xlink:label="loc_us-gaap_SeveranceCosts1_DE5A357E78069F328341325BEEA2484D" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_5234F47EE238B2273AD7325BEEA23DCA" xlink:to="loc_us-gaap_SeveranceCosts1_DE5A357E78069F328341325BEEA2484D" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AssetImpairmentCharges" xlink:label="loc_us-gaap_AssetImpairmentCharges_D77711DFBA6B2B09EBF4325BEEA224DE" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_5234F47EE238B2273AD7325BEEA23DCA" xlink:to="loc_us-gaap_AssetImpairmentCharges_D77711DFBA6B2B09EBF4325BEEA224DE" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_RestructuringSettlementAndImpairmentProvisions" xlink:label="loc_us-gaap_RestructuringSettlementAndImpairmentProvisions_375C7C9644C9FE50A716325BEEA2F9DC" xlink:type="locator" />
    <definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_5234F47EE238B2273AD7325BEEA23DCA" xlink:to="loc_us-gaap_RestructuringSettlementAndImpairmentProvisions_375C7C9644C9FE50A716325BEEA2F9DC" xlink:type="arc" />
  </definitionLink>
  <definitionLink xlink:role="http://www.lilly.com/role/BasisOfPresentation" xlink:type="extended" />
  <definitionLink xlink:role="http://www.lilly.com/role/CollaborationsAndOtherArrangements" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems" xlink:label="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_9A90DE015448BD0FA138A5DAF511AE5C" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable" xlink:label="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_5DBE44D0E778245C6420A5DAF511065E" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_9A90DE015448BD0FA138A5DAF511AE5C" xlink:to="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_5DBE44D0E778245C6420A5DAF511065E" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_TypeOfArrangementAxis" xlink:label="loc_us-gaap_TypeOfArrangementAxis_B0C2E613C77BB46A8A87A5DAF511F76D" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_5DBE44D0E778245C6420A5DAF511065E" xlink:to="loc_us-gaap_TypeOfArrangementAxis_B0C2E613C77BB46A8A87A5DAF511F76D" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_46DAA0E7321090699CDFA5DAF5116627_default" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_TypeOfArrangementAxis_B0C2E613C77BB46A8A87A5DAF511F76D" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_46DAA0E7321090699CDFA5DAF5116627_default" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_46DAA0E7321090699CDFA5DAF5116627" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_TypeOfArrangementAxis_B0C2E613C77BB46A8A87A5DAF511F76D" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_46DAA0E7321090699CDFA5DAF5116627" xlink:type="arc" />
  </definitionLink>
  <definitionLink xlink:role="http://www.lilly.com/role/CollaborationsAndOtherArrangementsDetails" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_42B0EFDFB4411DE868B9325BEEE85309" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable" xlink:label="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_7661FC2F4649CCB02A6C325BEEE03374" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_42B0EFDFB4411DE868B9325BEEE85309" xlink:to="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_7661FC2F4649CCB02A6C325BEEE03374" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_BusinessAcquisitionAxis" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_F0ADAD284464A5C09860325BEEE06479" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_7661FC2F4649CCB02A6C325BEEE03374" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_F0ADAD284464A5C09860325BEEE06479" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_A0AA3DFC727911BDDB70325BEEE014B2_default" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_F0ADAD284464A5C09860325BEEE06479" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_A0AA3DFC727911BDDB70325BEEE014B2_default" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_A0AA3DFC727911BDDB70325BEEE014B2" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_F0ADAD284464A5C09860325BEEE06479" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_A0AA3DFC727911BDDB70325BEEE014B2" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_ErbituxAcquisitionMember" xlink:label="loc_lly_ErbituxAcquisitionMember_9FC678A335F1FC7D600B325BEEE093A2" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_A0AA3DFC727911BDDB70325BEEE014B2" xlink:to="loc_lly_ErbituxAcquisitionMember_9FC678A335F1FC7D600B325BEEE093A2" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_StatementBusinessSegmentsAxis" xlink:label="loc_us-gaap_StatementBusinessSegmentsAxis_C3D77B5A7FD5C15133D2325BEEE0926B" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_7661FC2F4649CCB02A6C325BEEE03374" xlink:to="loc_us-gaap_StatementBusinessSegmentsAxis_C3D77B5A7FD5C15133D2325BEEE0926B" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SegmentDomain" xlink:label="loc_us-gaap_SegmentDomain_2331CB594937F0498507325BEEE0A723_default" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_C3D77B5A7FD5C15133D2325BEEE0926B" xlink:to="loc_us-gaap_SegmentDomain_2331CB594937F0498507325BEEE0A723_default" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SegmentDomain" xlink:label="loc_us-gaap_SegmentDomain_2331CB594937F0498507325BEEE0A723" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_C3D77B5A7FD5C15133D2325BEEE0926B" xlink:to="loc_us-gaap_SegmentDomain_2331CB594937F0498507325BEEE0A723" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_HumanPharmaceuticalProductsMember" xlink:label="loc_lly_HumanPharmaceuticalProductsMember_238437359D8C139FCF0E325BEEE0E924" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_2331CB594937F0498507325BEEE0A723" xlink:to="loc_lly_HumanPharmaceuticalProductsMember_238437359D8C139FCF0E325BEEE0E924" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SubsequentEventTypeAxis" xlink:label="loc_us-gaap_SubsequentEventTypeAxis_823B3DE3C6A7EE20834E325BEEE092E4" xlink:type="locator" />
    <definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_7661FC2F4649CCB02A6C325BEEE03374" xlink:to="loc_us-gaap_SubsequentEventTypeAxis_823B3DE3C6A7EE20834E325BEEE092E4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SubsequentEventTypeDomain" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_67E4B9C2A29C333335EF325BEEE0EA21_default" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_823B3DE3C6A7EE20834E325BEEE092E4" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_67E4B9C2A29C333335EF325BEEE0EA21_default" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SubsequentEventTypeDomain" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_67E4B9C2A29C333335EF325BEEE0EA21" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_823B3DE3C6A7EE20834E325BEEE092E4" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_67E4B9C2A29C333335EF325BEEE0EA21" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SubsequentEventMember" xlink:label="loc_us-gaap_SubsequentEventMember_4045DC190ED25D3AEC50325BEEE0A1F5" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsequentEventTypeDomain_67E4B9C2A29C333335EF325BEEE0EA21" xlink:to="loc_us-gaap_SubsequentEventMember_4045DC190ED25D3AEC50325BEEE0A1F5" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_TypeOfArrangementAxis" xlink:label="loc_us-gaap_TypeOfArrangementAxis_D4F2E1BE3AB8DEBD8C04325BEEE1E991" xlink:type="locator" />
    <definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_7661FC2F4649CCB02A6C325BEEE03374" xlink:to="loc_us-gaap_TypeOfArrangementAxis_D4F2E1BE3AB8DEBD8C04325BEEE1E991" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_032F99BB95BA402914BE325BEEE1EBFB_default" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_TypeOfArrangementAxis_D4F2E1BE3AB8DEBD8C04325BEEE1E991" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_032F99BB95BA402914BE325BEEE1EBFB_default" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_032F99BB95BA402914BE325BEEE1EBFB" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_TypeOfArrangementAxis_D4F2E1BE3AB8DEBD8C04325BEEE1E991" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_032F99BB95BA402914BE325BEEE1EBFB" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_AcquisitionTermsContingentConsiderationMember" xlink:label="loc_lly_AcquisitionTermsContingentConsiderationMember_424BB98F82039F739485325BEEE1B452" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_032F99BB95BA402914BE325BEEE1EBFB" xlink:to="loc_lly_AcquisitionTermsContingentConsiderationMember_424BB98F82039F739485325BEEE1B452" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_RevenueShareMember" xlink:label="loc_lly_RevenueShareMember_BE6C0CCC0912CDBA8241325BEEE14699" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_032F99BB95BA402914BE325BEEE1EBFB" xlink:to="loc_lly_RevenueShareMember_BE6C0CCC0912CDBA8241325BEEE14699" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_ProfitAndDevelopmentAndMarketingShareMember" xlink:label="loc_lly_ProfitAndDevelopmentAndMarketingShareMember_F376DB432AAB0C4E5B7A325BEEE1805D" xlink:type="locator" />
    <definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_032F99BB95BA402914BE325BEEE1EBFB" xlink:to="loc_lly_ProfitAndDevelopmentAndMarketingShareMember_F376DB432AAB0C4E5B7A325BEEE1805D" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SellingAndMarketingExpenseMember" xlink:label="loc_us-gaap_SellingAndMarketingExpenseMember_EB2DA41851A0C1C9DDB3325BEEE62DF7" xlink:type="locator" />
    <definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_032F99BB95BA402914BE325BEEE1EBFB" xlink:to="loc_us-gaap_SellingAndMarketingExpenseMember_EB2DA41851A0C1C9DDB3325BEEE62DF7" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ResearchAndDevelopmentExpenseMember" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpenseMember_86504C7F5E15B3B74256325BEEE69A43" xlink:type="locator" />
    <definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_032F99BB95BA402914BE325BEEE1EBFB" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpenseMember_86504C7F5E15B3B74256325BEEE69A43" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_ResearchAndDevelopmentAndMarketingAndSellingExpenseMember" xlink:label="loc_lly_ResearchAndDevelopmentAndMarketingAndSellingExpenseMember_A5B66468EFBE280CC793325BEEE68B1E" xlink:type="locator" />
    <definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_032F99BB95BA402914BE325BEEE1EBFB" xlink:to="loc_lly_ResearchAndDevelopmentAndMarketingAndSellingExpenseMember_A5B66468EFBE280CC793325BEEE68B1E" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_MilestonePaymentsDevelopmentandRegulatoryCapitalizedMember" xlink:label="loc_lly_MilestonePaymentsDevelopmentandRegulatoryCapitalizedMember_5D62802670B8A963FB1E325BEEE6E2C5" xlink:type="locator" />
    <definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_032F99BB95BA402914BE325BEEE1EBFB" xlink:to="loc_lly_MilestonePaymentsDevelopmentandRegulatoryCapitalizedMember_5D62802670B8A963FB1E325BEEE6E2C5" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_MilestonePaymentsDevelopmentandRegulatoryCapitalizedCumulativeMember" xlink:label="loc_lly_MilestonePaymentsDevelopmentandRegulatoryCapitalizedCumulativeMember_A55B0EEE533C2476B847325BEEE6358F" xlink:type="locator" />
    <definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_032F99BB95BA402914BE325BEEE1EBFB" xlink:to="loc_lly_MilestonePaymentsDevelopmentandRegulatoryCapitalizedCumulativeMember_A55B0EEE533C2476B847325BEEE6358F" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_MilestonePaymentsDevelopmentandRegulatoryExpensedMember" xlink:label="loc_lly_MilestonePaymentsDevelopmentandRegulatoryExpensedMember_4C0EA1205733711B4890325BEEE63C8A" xlink:type="locator" />
    <definitionArc order="9" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_032F99BB95BA402914BE325BEEE1EBFB" xlink:to="loc_lly_MilestonePaymentsDevelopmentandRegulatoryExpensedMember_4C0EA1205733711B4890325BEEE63C8A" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_MilestonePaymentsSalesBasedMember" xlink:label="loc_lly_MilestonePaymentsSalesBasedMember_90A688D193ADB44B9872325BEEE60704" xlink:type="locator" />
    <definitionArc order="10" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_032F99BB95BA402914BE325BEEE1EBFB" xlink:to="loc_lly_MilestonePaymentsSalesBasedMember_90A688D193ADB44B9872325BEEE60704" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_MilestonePaymentsDevelopmentAndRegulatoryMember" xlink:label="loc_lly_MilestonePaymentsDevelopmentAndRegulatoryMember_B0F379C5DECBB3F0EC79325BEEE66414" xlink:type="locator" />
    <definitionArc order="11" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_032F99BB95BA402914BE325BEEE1EBFB" xlink:to="loc_lly_MilestonePaymentsDevelopmentAndRegulatoryMember_B0F379C5DECBB3F0EC79325BEEE66414" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_MilestonePaymentsDevelopmentandRegulatoryFirstIndicationMember" xlink:label="loc_lly_MilestonePaymentsDevelopmentandRegulatoryFirstIndicationMember_6E8DECE9A29F9D1BBAFE325BEEE7A7F3" xlink:type="locator" />
    <definitionArc order="12" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_032F99BB95BA402914BE325BEEE1EBFB" xlink:to="loc_lly_MilestonePaymentsDevelopmentandRegulatoryFirstIndicationMember_6E8DECE9A29F9D1BBAFE325BEEE7A7F3" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_RoyaltyAgreementTermsMember" xlink:label="loc_us-gaap_RoyaltyAgreementTermsMember_CEC4A9F6BD9DF44770E1325BEEE72170" xlink:type="locator" />
    <definitionArc order="13" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_032F99BB95BA402914BE325BEEE1EBFB" xlink:to="loc_us-gaap_RoyaltyAgreementTermsMember_CEC4A9F6BD9DF44770E1325BEEE72170" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_UpfrontPaymentMember" xlink:label="loc_lly_UpfrontPaymentMember_B5A1B9DBDD5DD54491AA325BEEE72C56" xlink:type="locator" />
    <definitionArc order="14" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_032F99BB95BA402914BE325BEEE1EBFB" xlink:to="loc_lly_UpfrontPaymentMember_B5A1B9DBDD5DD54491AA325BEEE72C56" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CollaborativeArrangementMember" xlink:label="loc_us-gaap_CollaborativeArrangementMember_C94F0CC4B6C28DD84692325BEEE74A6F" xlink:type="locator" />
    <definitionArc order="15" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_032F99BB95BA402914BE325BEEE1EBFB" xlink:to="loc_us-gaap_CollaborativeArrangementMember_C94F0CC4B6C28DD84692325BEEE74A6F" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_StatementGeographicalAxis" xlink:label="loc_us-gaap_StatementGeographicalAxis_5BC681B9E9DA3FC84F0F325BEEE7BC9E" xlink:type="locator" />
    <definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_7661FC2F4649CCB02A6C325BEEE03374" xlink:to="loc_us-gaap_StatementGeographicalAxis_5BC681B9E9DA3FC84F0F325BEEE7BC9E" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SegmentGeographicalDomain" xlink:label="loc_us-gaap_SegmentGeographicalDomain_237DD418C9C00CB6D9DB325BEEE7F669_default" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementGeographicalAxis_5BC681B9E9DA3FC84F0F325BEEE7BC9E" xlink:to="loc_us-gaap_SegmentGeographicalDomain_237DD418C9C00CB6D9DB325BEEE7F669_default" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SegmentGeographicalDomain" xlink:label="loc_us-gaap_SegmentGeographicalDomain_237DD418C9C00CB6D9DB325BEEE7F669" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementGeographicalAxis_5BC681B9E9DA3FC84F0F325BEEE7BC9E" xlink:to="loc_us-gaap_SegmentGeographicalDomain_237DD418C9C00CB6D9DB325BEEE7F669" xlink:type="arc" />
    <loc xlink:href="http://xbrl.sec.gov/country/2016/country-2016-01-31.xsd#country_US" xlink:label="loc_country_US_056E73000396028F7A42325BEEE7B672" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentGeographicalDomain_237DD418C9C00CB6D9DB325BEEE7F669" xlink:to="loc_country_US_056E73000396028F7A42325BEEE7B672" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_OutsideUnitedStatesMember" xlink:label="loc_lly_OutsideUnitedStatesMember_1879A28F0BFD8779A131325BEEE7D1C0" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentGeographicalDomain_237DD418C9C00CB6D9DB325BEEE7F669" xlink:to="loc_lly_OutsideUnitedStatesMember_1879A28F0BFD8779A131325BEEE7D1C0" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ProductOrServiceAxis" xlink:label="loc_us-gaap_ProductOrServiceAxis_BEE449D71750D6491964325BEEE70699" xlink:type="locator" />
    <definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_7661FC2F4649CCB02A6C325BEEE03374" xlink:to="loc_us-gaap_ProductOrServiceAxis_BEE449D71750D6491964325BEEE70699" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ProductsAndServicesDomain" xlink:label="loc_us-gaap_ProductsAndServicesDomain_BB6B1B52D01352BF98C5325BEEE7852C_default" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ProductOrServiceAxis_BEE449D71750D6491964325BEEE70699" xlink:to="loc_us-gaap_ProductsAndServicesDomain_BB6B1B52D01352BF98C5325BEEE7852C_default" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ProductsAndServicesDomain" xlink:label="loc_us-gaap_ProductsAndServicesDomain_BB6B1B52D01352BF98C5325BEEE7852C" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ProductOrServiceAxis_BEE449D71750D6491964325BEEE70699" xlink:to="loc_us-gaap_ProductsAndServicesDomain_BB6B1B52D01352BF98C5325BEEE7852C" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_ErbituxAPIMember" xlink:label="loc_lly_ErbituxAPIMember_AE392A92BA52FD263871325BEEE772F9" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ProductsAndServicesDomain_BB6B1B52D01352BF98C5325BEEE7852C" xlink:to="loc_lly_ErbituxAPIMember_AE392A92BA52FD263871325BEEE772F9" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_BiCompoundsMember" xlink:label="loc_lly_BiCompoundsMember_25718E537C6B6A65A1A4325BEEE7D70A" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ProductsAndServicesDomain_BB6B1B52D01352BF98C5325BEEE7852C" xlink:to="loc_lly_BiCompoundsMember_25718E537C6B6A65A1A4325BEEE7D70A" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_BasaglarMember" xlink:label="loc_lly_BasaglarMember_B3D4D7BF16AF616485E1325BEEE7DA10" xlink:type="locator" />
    <definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ProductsAndServicesDomain_BB6B1B52D01352BF98C5325BEEE7852C" xlink:to="loc_lly_BasaglarMember_B3D4D7BF16AF616485E1325BEEE7DA10" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_ErbituxMember" xlink:label="loc_lly_ErbituxMember_C4DA0AA3B335E16F9352325BEEE7E9E7" xlink:type="locator" />
    <definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ProductsAndServicesDomain_BB6B1B52D01352BF98C5325BEEE7852C" xlink:to="loc_lly_ErbituxMember_C4DA0AA3B335E16F9352325BEEE7E9E7" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_EffientMember" xlink:label="loc_lly_EffientMember_6132770FE0D19AD8AE06325BEEE829F1" xlink:type="locator" />
    <definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ProductsAndServicesDomain_BB6B1B52D01352BF98C5325BEEE7852C" xlink:to="loc_lly_EffientMember_6132770FE0D19AD8AE06325BEEE829F1" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_SolanezumabMember" xlink:label="loc_lly_SolanezumabMember_1C4D4818CAC115B6C192325BEEE8ED14" xlink:type="locator" />
    <definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ProductsAndServicesDomain_BB6B1B52D01352BF98C5325BEEE7852C" xlink:to="loc_lly_SolanezumabMember_1C4D4818CAC115B6C192325BEEE8ED14" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_TrajentaBIMember" xlink:label="loc_lly_TrajentaBIMember_EFB95A6428AF76FAE042325BEEE83456" xlink:type="locator" />
    <definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ProductsAndServicesDomain_BB6B1B52D01352BF98C5325BEEE7852C" xlink:to="loc_lly_TrajentaBIMember_EFB95A6428AF76FAE042325BEEE83456" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_JardianceBIMember" xlink:label="loc_lly_JardianceBIMember_534C79967B3D319F0B65325BEEE8C15A" xlink:type="locator" />
    <definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ProductsAndServicesDomain_BB6B1B52D01352BF98C5325BEEE7852C" xlink:to="loc_lly_JardianceBIMember_534C79967B3D319F0B65325BEEE8C15A" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_BaricitinibMember" xlink:label="loc_lly_BaricitinibMember_238BF838A0E3220EDE5D325BEEE8B4E9" xlink:type="locator" />
    <definitionArc order="9" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ProductsAndServicesDomain_BB6B1B52D01352BF98C5325BEEE7852C" xlink:to="loc_lly_BaricitinibMember_238BF838A0E3220EDE5D325BEEE8B4E9" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_TanezumabMember" xlink:label="loc_lly_TanezumabMember_8A467D383EED87954FF6325BEEE8FA87" xlink:type="locator" />
    <definitionArc order="10" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ProductsAndServicesDomain_BB6B1B52D01352BF98C5325BEEE7852C" xlink:to="loc_lly_TanezumabMember_8A467D383EED87954FF6325BEEE8FA87" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_BACEAZInhibitorMember" xlink:label="loc_lly_BACEAZInhibitorMember_70E0BE05326D217EDEE6325BEEE81FD7" xlink:type="locator" />
    <definitionArc order="11" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ProductsAndServicesDomain_BB6B1B52D01352BF98C5325BEEE7852C" xlink:to="loc_lly_BACEAZInhibitorMember_70E0BE05326D217EDEE6325BEEE81FD7" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_OtherSalesRevenueNet" xlink:label="loc_us-gaap_OtherSalesRevenueNet_ADF9DD82AD552130DAF4325BEEE89347" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_42B0EFDFB4411DE868B9325BEEE85309" xlink:to="loc_us-gaap_OtherSalesRevenueNet_ADF9DD82AD552130DAF4325BEEE89347" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_Revenues" xlink:label="loc_us-gaap_Revenues_EB8525D110228D0091AF325BEEE8ABDF" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_42B0EFDFB4411DE868B9325BEEE85309" xlink:to="loc_us-gaap_Revenues_EB8525D110228D0091AF325BEEE8ABDF" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ResearchAndDevelopmentExpense" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_38D9862AE205D6E59A21325BEEED614F" xlink:type="locator" />
    <definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_42B0EFDFB4411DE868B9325BEEE85309" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_38D9862AE205D6E59A21325BEEED614F" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_CollaborativeArrangementRightsAndObligationsTerms" xlink:label="loc_lly_CollaborativeArrangementRightsAndObligationsTerms_CEAAD70C2DFE53F402B8325BEEED771D" xlink:type="locator" />
    <definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_42B0EFDFB4411DE868B9325BEEE85309" xlink:to="loc_lly_CollaborativeArrangementRightsAndObligationsTerms_CEAAD70C2DFE53F402B8325BEEED771D" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_NonoperatingIncomeExpense" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_5DD6921A1169FFF2BDE5325BEEEDB39E" xlink:type="locator" />
    <definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_42B0EFDFB4411DE868B9325BEEE85309" xlink:to="loc_us-gaap_NonoperatingIncomeExpense_5DD6921A1169FFF2BDE5325BEEEDB39E" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SellingGeneralAndAdministrativeExpense" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpense_0226B74E248E3408F5C5325BEEEDCE45" xlink:type="locator" />
    <definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_42B0EFDFB4411DE868B9325BEEE85309" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpense_0226B74E248E3408F5C5325BEEEDCE45" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_CollaborativeArrangementRightsandObligationsAmount" xlink:label="loc_lly_CollaborativeArrangementRightsandObligationsAmount_249B197867DCC6D98B6E325BEEEDCD19" xlink:type="locator" />
    <definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_42B0EFDFB4411DE868B9325BEEE85309" xlink:to="loc_lly_CollaborativeArrangementRightsandObligationsAmount_249B197867DCC6D98B6E325BEEEDCD19" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_CollaborativeArrangementRightsAndObligationsTermsOfArrangementPeriod" xlink:label="loc_lly_CollaborativeArrangementRightsAndObligationsTermsOfArrangementPeriod_173DB6DE606CAE0EA684325BEEEDFF65" xlink:type="locator" />
    <definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_42B0EFDFB4411DE868B9325BEEE85309" xlink:to="loc_lly_CollaborativeArrangementRightsAndObligationsTermsOfArrangementPeriod_173DB6DE606CAE0EA684325BEEEDFF65" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DebtInstrumentInterestRateStatedPercentage" xlink:label="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_F1658EF8BEC9780EAA11325BEEEE2583" xlink:type="locator" />
    <definitionArc order="9" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_42B0EFDFB4411DE868B9325BEEE85309" xlink:to="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_F1658EF8BEC9780EAA11325BEEEE2583" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_CollaborativeArrangementRightsAndObligationsPercent" xlink:label="loc_lly_CollaborativeArrangementRightsAndObligationsPercent_9D721D573601612228BC325BEEEE4310" xlink:type="locator" />
    <definitionArc order="10" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_42B0EFDFB4411DE868B9325BEEE85309" xlink:to="loc_lly_CollaborativeArrangementRightsAndObligationsPercent_9D721D573601612228BC325BEEEE4310" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles_E1AE30CBCADAE62A01EE325BEEEEC690" xlink:type="locator" />
    <definitionArc order="11" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_42B0EFDFB4411DE868B9325BEEE85309" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles_E1AE30CBCADAE62A01EE325BEEEEC690" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxAssetsNoncurrent" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxAssetsNoncurrent_CD566E9AF3EBF1B4223F325BEEEE365E" xlink:type="locator" />
    <definitionArc order="12" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_42B0EFDFB4411DE868B9325BEEE85309" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxAssetsNoncurrent_CD566E9AF3EBF1B4223F325BEEEE365E" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxLiabilitiesNoncurrent" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxLiabilitiesNoncurrent_116EE0D7C70A552E17BA325BEEEE73D1" xlink:type="locator" />
    <definitionArc order="13" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_42B0EFDFB4411DE868B9325BEEE85309" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxLiabilitiesNoncurrent_116EE0D7C70A552E17BA325BEEEE73D1" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssets" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssets_1AB0301CFC2531003930325BEEEE23D6" xlink:type="locator" />
    <definitionArc order="14" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_42B0EFDFB4411DE868B9325BEEE85309" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssets_1AB0301CFC2531003930325BEEEE23D6" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_DF691D8E1FB023CE22A1325BEEEE761B" xlink:type="locator" />
    <definitionArc order="15" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_42B0EFDFB4411DE868B9325BEEE85309" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_DF691D8E1FB023CE22A1325BEEEE761B" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedContingentLiability" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedContingentLiability_733C2658FE9022197D62325BEEEE7036" xlink:type="locator" />
    <definitionArc order="16" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_42B0EFDFB4411DE868B9325BEEE85309" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedContingentLiability_733C2658FE9022197D62325BEEEE7036" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_BusinessAcquisitionsProFormaRevenue" xlink:label="loc_us-gaap_BusinessAcquisitionsProFormaRevenue_A908344AFFA653BB38B7325BEEEE0F88" xlink:type="locator" />
    <definitionArc order="17" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_42B0EFDFB4411DE868B9325BEEE85309" xlink:to="loc_us-gaap_BusinessAcquisitionsProFormaRevenue_A908344AFFA653BB38B7325BEEEE0F88" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_AcquiredInProcessResearchAndDevelopment" xlink:label="loc_lly_AcquiredInProcessResearchAndDevelopment_FFFE544C1018C7179A29325BEEEEFF17" xlink:type="locator" />
    <definitionArc order="18" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_42B0EFDFB4411DE868B9325BEEE85309" xlink:to="loc_lly_AcquiredInProcessResearchAndDevelopment_FFFE544C1018C7179A29325BEEEEFF17" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SalesRevenueGoodsNet" xlink:label="loc_us-gaap_SalesRevenueGoodsNet_A12FAEBD96F63F2349FE325BEEEE7273" xlink:type="locator" />
    <definitionArc order="19" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_42B0EFDFB4411DE868B9325BEEE85309" xlink:to="loc_us-gaap_SalesRevenueGoodsNet_A12FAEBD96F63F2349FE325BEEEE7273" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AmortizationOfIntangibleAssets" xlink:label="loc_us-gaap_AmortizationOfIntangibleAssets_3468D2C362317DE95E96325BEEEE6D7C" xlink:type="locator" />
    <definitionArc order="20" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_42B0EFDFB4411DE868B9325BEEE85309" xlink:to="loc_us-gaap_AmortizationOfIntangibleAssets_3468D2C362317DE95E96325BEEEE6D7C" xlink:type="arc" />
  </definitionLink>
  <definitionLink xlink:role="http://www.lilly.com/role/CollaborationsAndOtherArrangementsTables" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_DD41A73A5538E2EB97E3A5DAF50AFC90" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable" xlink:label="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_F070B05146BE30906D8AA5DAF50946B3" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_DD41A73A5538E2EB97E3A5DAF50AFC90" xlink:to="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_F070B05146BE30906D8AA5DAF50946B3" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_BusinessAcquisitionAxis" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_BC574F49E430E5F84D28A5DAF5093320" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_F070B05146BE30906D8AA5DAF50946B3" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_BC574F49E430E5F84D28A5DAF5093320" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_E84E8A62769E947D4BA2A5DAF50903A6_default" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_BC574F49E430E5F84D28A5DAF5093320" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_E84E8A62769E947D4BA2A5DAF50903A6_default" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_E84E8A62769E947D4BA2A5DAF50903A6" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_BC574F49E430E5F84D28A5DAF5093320" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_E84E8A62769E947D4BA2A5DAF50903A6" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_ErbituxAcquisitionMember" xlink:label="loc_lly_ErbituxAcquisitionMember_15F8769FDEA6223C709BA5DAF5099807" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_E84E8A62769E947D4BA2A5DAF50903A6" xlink:to="loc_lly_ErbituxAcquisitionMember_15F8769FDEA6223C709BA5DAF5099807" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_TypeOfArrangementAxis" xlink:label="loc_us-gaap_TypeOfArrangementAxis_2ED11CF74EE1754AB2C8A5DAF50978AD" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_F070B05146BE30906D8AA5DAF50946B3" xlink:to="loc_us-gaap_TypeOfArrangementAxis_2ED11CF74EE1754AB2C8A5DAF50978AD" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_2FBB9D53C7343F3707CAA5DAF5091135_default" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_TypeOfArrangementAxis_2ED11CF74EE1754AB2C8A5DAF50978AD" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_2FBB9D53C7343F3707CAA5DAF5091135_default" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_2FBB9D53C7343F3707CAA5DAF5091135" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_TypeOfArrangementAxis_2ED11CF74EE1754AB2C8A5DAF50978AD" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_2FBB9D53C7343F3707CAA5DAF5091135" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SellingGeneralAndAdministrativeExpensesMember" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpensesMember_4812C25CACB805D96CA7A5DAF50AFB11" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_2FBB9D53C7343F3707CAA5DAF5091135" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpensesMember_4812C25CACB805D96CA7A5DAF50AFB11" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CollaborativeArrangementMember" xlink:label="loc_us-gaap_CollaborativeArrangementMember_E43ACEFBF2368FA77A06A5DAF50AA174" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_2FBB9D53C7343F3707CAA5DAF5091135" xlink:to="loc_us-gaap_CollaborativeArrangementMember_E43ACEFBF2368FA77A06A5DAF50AA174" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ProductOrServiceAxis" xlink:label="loc_us-gaap_ProductOrServiceAxis_1371503EF27F51B5232CA5DAF50A9136" xlink:type="locator" />
    <definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_F070B05146BE30906D8AA5DAF50946B3" xlink:to="loc_us-gaap_ProductOrServiceAxis_1371503EF27F51B5232CA5DAF50A9136" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ProductsAndServicesDomain" xlink:label="loc_us-gaap_ProductsAndServicesDomain_96CD8C198A9CCE7837E1A5DAF50A3EAC_default" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ProductOrServiceAxis_1371503EF27F51B5232CA5DAF50A9136" xlink:to="loc_us-gaap_ProductsAndServicesDomain_96CD8C198A9CCE7837E1A5DAF50A3EAC_default" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ProductsAndServicesDomain" xlink:label="loc_us-gaap_ProductsAndServicesDomain_96CD8C198A9CCE7837E1A5DAF50A3EAC" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ProductOrServiceAxis_1371503EF27F51B5232CA5DAF50A9136" xlink:to="loc_us-gaap_ProductsAndServicesDomain_96CD8C198A9CCE7837E1A5DAF50A3EAC" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_DiabetesCollaborationMember" xlink:label="loc_lly_DiabetesCollaborationMember_3C0AB07401D2D759AC8BA5DAF50A3E97" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ProductsAndServicesDomain_96CD8C198A9CCE7837E1A5DAF50A3EAC" xlink:to="loc_lly_DiabetesCollaborationMember_3C0AB07401D2D759AC8BA5DAF50A3E97" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_BiCompoundsMember" xlink:label="loc_lly_BiCompoundsMember_73E60208CF65138BD000A5DAF50ABCDF" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ProductsAndServicesDomain_96CD8C198A9CCE7837E1A5DAF50A3EAC" xlink:to="loc_lly_BiCompoundsMember_73E60208CF65138BD000A5DAF50ABCDF" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_ErbituxMember" xlink:label="loc_lly_ErbituxMember_2A4857FEB1D0B7073FA8A5DAF50AAE65" xlink:type="locator" />
    <definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ProductsAndServicesDomain_96CD8C198A9CCE7837E1A5DAF50A3EAC" xlink:to="loc_lly_ErbituxMember_2A4857FEB1D0B7073FA8A5DAF50AAE65" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_EffientMember" xlink:label="loc_lly_EffientMember_6E8378C3E7A323DEC2B7A5DAF50ABC9D" xlink:type="locator" />
    <definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ProductsAndServicesDomain_96CD8C198A9CCE7837E1A5DAF50A3EAC" xlink:to="loc_lly_EffientMember_6E8378C3E7A323DEC2B7A5DAF50ABC9D" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ScheduleOfRecognizedIdentifiedAssetsAcquiredAndLiabilitiesAssumedTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfRecognizedIdentifiedAssetsAcquiredAndLiabilitiesAssumedTableTextBlock_5CB9C0AE06724469D704A5DAF50AF2F4" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_DD41A73A5538E2EB97E3A5DAF50AFC90" xlink:to="loc_us-gaap_ScheduleOfRecognizedIdentifiedAssetsAcquiredAndLiabilitiesAssumedTableTextBlock_5CB9C0AE06724469D704A5DAF50AF2F4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTableTextBlock_0F7279328762654770B4A5DAF50A553A" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_DD41A73A5538E2EB97E3A5DAF50AFC90" xlink:to="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTableTextBlock_0F7279328762654770B4A5DAF50A553A" xlink:type="arc" />
  </definitionLink>
  <definitionLink xlink:role="http://www.lilly.com/role/ConsolidatedCondensedBalanceSheets" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_5D4A22DAD89FA638A9D92770A0386C8F" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_StatementTable" xlink:label="loc_us-gaap_StatementTable_A16579EE373D5BDF8B212770A036690D" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_5D4A22DAD89FA638A9D92770A0386C8F" xlink:to="loc_us-gaap_StatementTable_A16579EE373D5BDF8B212770A036690D" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_StatementScenarioAxis" xlink:label="loc_us-gaap_StatementScenarioAxis_D4C8B8DB364BA642F9322770A036DEAD" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_A16579EE373D5BDF8B212770A036690D" xlink:to="loc_us-gaap_StatementScenarioAxis_D4C8B8DB364BA642F9322770A036DEAD" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ScenarioUnspecifiedDomain" xlink:label="loc_us-gaap_ScenarioUnspecifiedDomain_4FDFCD09A4659710AFF92770A036137F_default" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementScenarioAxis_D4C8B8DB364BA642F9322770A036DEAD" xlink:to="loc_us-gaap_ScenarioUnspecifiedDomain_4FDFCD09A4659710AFF92770A036137F_default" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ScenarioUnspecifiedDomain" xlink:label="loc_us-gaap_ScenarioUnspecifiedDomain_4FDFCD09A4659710AFF92770A036137F" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementScenarioAxis_D4C8B8DB364BA642F9322770A036DEAD" xlink:to="loc_us-gaap_ScenarioUnspecifiedDomain_4FDFCD09A4659710AFF92770A036137F" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_StatementClassOfStockAxis" xlink:label="loc_us-gaap_StatementClassOfStockAxis_EEB9783328D1A8ADAE502770A036A3FD" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_A16579EE373D5BDF8B212770A036690D" xlink:to="loc_us-gaap_StatementClassOfStockAxis_EEB9783328D1A8ADAE502770A036A3FD" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ClassOfStockDomain" xlink:label="loc_us-gaap_ClassOfStockDomain_8497376AF1964CFCCE0A2770A0361E22_default" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementClassOfStockAxis_EEB9783328D1A8ADAE502770A036A3FD" xlink:to="loc_us-gaap_ClassOfStockDomain_8497376AF1964CFCCE0A2770A0361E22_default" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ClassOfStockDomain" xlink:label="loc_us-gaap_ClassOfStockDomain_8497376AF1964CFCCE0A2770A0361E22" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementClassOfStockAxis_EEB9783328D1A8ADAE502770A036A3FD" xlink:to="loc_us-gaap_ClassOfStockDomain_8497376AF1964CFCCE0A2770A0361E22" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AssetsAbstract" xlink:label="loc_us-gaap_AssetsAbstract_83F72E226E4122379D9F2770A0382207" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_5D4A22DAD89FA638A9D92770A0386C8F" xlink:to="loc_us-gaap_AssetsAbstract_83F72E226E4122379D9F2770A0382207" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AssetsCurrentAbstract" xlink:label="loc_us-gaap_AssetsCurrentAbstract_62A04AF6F30BCBCD07D92770A038C25E" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsAbstract_83F72E226E4122379D9F2770A0382207" xlink:to="loc_us-gaap_AssetsCurrentAbstract_62A04AF6F30BCBCD07D92770A038C25E" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_1453B14FB387ACC300322770A038BE8F" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsCurrentAbstract_62A04AF6F30BCBCD07D92770A038C25E" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_1453B14FB387ACC300322770A038BE8F" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ShortTermInvestments" xlink:label="loc_us-gaap_ShortTermInvestments_59720FC1370DCE1A2D002770A038FDB7" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsCurrentAbstract_62A04AF6F30BCBCD07D92770A038C25E" xlink:to="loc_us-gaap_ShortTermInvestments_59720FC1370DCE1A2D002770A038FDB7" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AccountsReceivableNetCurrent" xlink:label="loc_us-gaap_AccountsReceivableNetCurrent_CA9A8132728E844CC5312770A038A954" xlink:type="locator" />
    <definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsCurrentAbstract_62A04AF6F30BCBCD07D92770A038C25E" xlink:to="loc_us-gaap_AccountsReceivableNetCurrent_CA9A8132728E844CC5312770A038A954" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_OtherReceivablesNetCurrent" xlink:label="loc_us-gaap_OtherReceivablesNetCurrent_602E74D647909B0327D52770A038904B" xlink:type="locator" />
    <definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsCurrentAbstract_62A04AF6F30BCBCD07D92770A038C25E" xlink:to="loc_us-gaap_OtherReceivablesNetCurrent_602E74D647909B0327D52770A038904B" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_InventoryNet" xlink:label="loc_us-gaap_InventoryNet_06B56EBDFC5349E575562770A038C5A3" xlink:type="locator" />
    <definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsCurrentAbstract_62A04AF6F30BCBCD07D92770A038C25E" xlink:to="loc_us-gaap_InventoryNet_06B56EBDFC5349E575562770A038C5A3" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_PrepaidExpenseCurrent" xlink:label="loc_us-gaap_PrepaidExpenseCurrent_2684198E4BFA906F09172770A038C1B5" xlink:type="locator" />
    <definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsCurrentAbstract_62A04AF6F30BCBCD07D92770A038C25E" xlink:to="loc_us-gaap_PrepaidExpenseCurrent_2684198E4BFA906F09172770A038C1B5" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AssetsCurrent" xlink:label="loc_us-gaap_AssetsCurrent_1488FEFF614E0F285B9D2770A038F3FF" xlink:type="locator" />
    <definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsCurrentAbstract_62A04AF6F30BCBCD07D92770A038C25E" xlink:to="loc_us-gaap_AssetsCurrent_1488FEFF614E0F285B9D2770A038F3FF" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AssetsNoncurrentAbstract" xlink:label="loc_us-gaap_AssetsNoncurrentAbstract_991A860B6194AA1037832770A038320A" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsAbstract_83F72E226E4122379D9F2770A0382207" xlink:to="loc_us-gaap_AssetsNoncurrentAbstract_991A860B6194AA1037832770A038320A" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_RestrictedCashAndCashEquivalentsNoncurrent" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalentsNoncurrent_C8C9DF7718E265A0E50D2770A0386BF9" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsNoncurrentAbstract_991A860B6194AA1037832770A038320A" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalentsNoncurrent_C8C9DF7718E265A0E50D2770A0386BF9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LongTermInvestments" xlink:label="loc_us-gaap_LongTermInvestments_D035A935064383B210942770A0385360" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsNoncurrentAbstract_991A860B6194AA1037832770A038320A" xlink:to="loc_us-gaap_LongTermInvestments_D035A935064383B210942770A0385360" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_Goodwill" xlink:label="loc_us-gaap_Goodwill_451EC541180E7EEBB3A72770A0385D81" xlink:type="locator" />
    <definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsNoncurrentAbstract_991A860B6194AA1037832770A038320A" xlink:to="loc_us-gaap_Goodwill_451EC541180E7EEBB3A72770A0385D81" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_IntangibleAssetsNetExcludingGoodwill" xlink:label="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_8D72068476F534DB944F2770A03859E5" xlink:type="locator" />
    <definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsNoncurrentAbstract_991A860B6194AA1037832770A038320A" xlink:to="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_8D72068476F534DB944F2770A03859E5" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_OtherAssetsNoncurrent" xlink:label="loc_us-gaap_OtherAssetsNoncurrent_44D06EC194C3ACE8FDE72770A038B0B3" xlink:type="locator" />
    <definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsNoncurrentAbstract_991A860B6194AA1037832770A038320A" xlink:to="loc_us-gaap_OtherAssetsNoncurrent_44D06EC194C3ACE8FDE72770A038B0B3" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AssetsNoncurrent" xlink:label="loc_us-gaap_AssetsNoncurrent_5EC5F61917E34F9B27082770A039B6F0" xlink:type="locator" />
    <definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsNoncurrentAbstract_991A860B6194AA1037832770A038320A" xlink:to="loc_us-gaap_AssetsNoncurrent_5EC5F61917E34F9B27082770A039B6F0" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_PropertyPlantAndEquipmentNetAbstract" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNetAbstract_98D71950FB777EF47B6A2770A039B5C3" xlink:type="locator" />
    <definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsNoncurrentAbstract_991A860B6194AA1037832770A038320A" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNetAbstract_98D71950FB777EF47B6A2770A039B5C3" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_PropertyPlantAndEquipmentGross" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentGross_BAD11AEBDF899F438BF42770A039E553" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNetAbstract_98D71950FB777EF47B6A2770A039B5C3" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentGross_BAD11AEBDF899F438BF42770A039E553" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment" xlink:label="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_0A314DCBD9D8E28480332770A0399EFA" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNetAbstract_98D71950FB777EF47B6A2770A039B5C3" xlink:to="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_0A314DCBD9D8E28480332770A0399EFA" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_PropertyPlantAndEquipmentNet" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_A2A856D76915AE083EA42770A03974B3" xlink:type="locator" />
    <definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNetAbstract_98D71950FB777EF47B6A2770A039B5C3" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_A2A856D76915AE083EA42770A03974B3" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_Assets" xlink:label="loc_us-gaap_Assets_EC92F48E4E7D371542062770A0392AF6" xlink:type="locator" />
    <definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsAbstract_83F72E226E4122379D9F2770A0382207" xlink:to="loc_us-gaap_Assets_EC92F48E4E7D371542062770A0392AF6" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LiabilitiesAndStockholdersEquityAbstract" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_754D5E7E2845E0AE154E2770A03942A3" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_5D4A22DAD89FA638A9D92770A0386C8F" xlink:to="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_754D5E7E2845E0AE154E2770A03942A3" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LiabilitiesCurrentAbstract" xlink:label="loc_us-gaap_LiabilitiesCurrentAbstract_3F7D2260EF467158E5982770A039E992" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_754D5E7E2845E0AE154E2770A03942A3" xlink:to="loc_us-gaap_LiabilitiesCurrentAbstract_3F7D2260EF467158E5982770A039E992" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DebtCurrent" xlink:label="loc_us-gaap_DebtCurrent_3E6C2DC47B36EB5D1D552770A039CB1D" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_3F7D2260EF467158E5982770A039E992" xlink:to="loc_us-gaap_DebtCurrent_3E6C2DC47B36EB5D1D552770A039CB1D" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AccountsPayableCurrent" xlink:label="loc_us-gaap_AccountsPayableCurrent_6BC0BBF2C23107FB5D5D2770A039E95C" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_3F7D2260EF467158E5982770A039E992" xlink:to="loc_us-gaap_AccountsPayableCurrent_6BC0BBF2C23107FB5D5D2770A039E95C" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_EmployeeRelatedLiabilitiesCurrent" xlink:label="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_9730D912F8EC1C087A532770A039AE0A" xlink:type="locator" />
    <definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_3F7D2260EF467158E5982770A039E992" xlink:to="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_9730D912F8EC1C087A532770A039AE0A" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_SalesRebatesAndDiscounts" xlink:label="loc_lly_SalesRebatesAndDiscounts_2C4448C0DA785C80B0192770A0397A4E" xlink:type="locator" />
    <definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_3F7D2260EF467158E5982770A039E992" xlink:to="loc_lly_SalesRebatesAndDiscounts_2C4448C0DA785C80B0192770A0397A4E" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DividendsPayableCurrent" xlink:label="loc_us-gaap_DividendsPayableCurrent_66FA89141B77AB0079E22770A0396B81" xlink:type="locator" />
    <definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_3F7D2260EF467158E5982770A039E992" xlink:to="loc_us-gaap_DividendsPayableCurrent_66FA89141B77AB0079E22770A0396B81" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_TaxesPayableCurrent" xlink:label="loc_us-gaap_TaxesPayableCurrent_533EDF503C94FCBDEF422770A0395359" xlink:type="locator" />
    <definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_3F7D2260EF467158E5982770A039E992" xlink:to="loc_us-gaap_TaxesPayableCurrent_533EDF503C94FCBDEF422770A0395359" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AccruedIncomeTaxesCurrent" xlink:label="loc_us-gaap_AccruedIncomeTaxesCurrent_648BD321A787EF3B49C42770A039DC28" xlink:type="locator" />
    <definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_3F7D2260EF467158E5982770A039E992" xlink:to="loc_us-gaap_AccruedIncomeTaxesCurrent_648BD321A787EF3B49C42770A039DC28" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DeferredTaxLiabilitiesCurrent" xlink:label="loc_us-gaap_DeferredTaxLiabilitiesCurrent_5E96C453B68EBC22FDE22770A039B810" xlink:type="locator" />
    <definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_3F7D2260EF467158E5982770A039E992" xlink:to="loc_us-gaap_DeferredTaxLiabilitiesCurrent_5E96C453B68EBC22FDE22770A039B810" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_OtherLiabilitiesCurrent" xlink:label="loc_us-gaap_OtherLiabilitiesCurrent_769D0C7FF6E269BD970F2770A03A0F93" xlink:type="locator" />
    <definitionArc order="9" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_3F7D2260EF467158E5982770A039E992" xlink:to="loc_us-gaap_OtherLiabilitiesCurrent_769D0C7FF6E269BD970F2770A03A0F93" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LiabilitiesCurrent" xlink:label="loc_us-gaap_LiabilitiesCurrent_CC09D3D3B943A633367A2770A03A1050" xlink:type="locator" />
    <definitionArc order="10" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_3F7D2260EF467158E5982770A039E992" xlink:to="loc_us-gaap_LiabilitiesCurrent_CC09D3D3B943A633367A2770A03A1050" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LiabilitiesNoncurrentAbstract" xlink:label="loc_us-gaap_LiabilitiesNoncurrentAbstract_9738F125526DBAB833EF2770A03AC808" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_754D5E7E2845E0AE154E2770A03942A3" xlink:to="loc_us-gaap_LiabilitiesNoncurrentAbstract_9738F125526DBAB833EF2770A03AC808" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LongTermDebtNoncurrent" xlink:label="loc_us-gaap_LongTermDebtNoncurrent_50B32518CEDE015AD6CF2770A03AB014" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesNoncurrentAbstract_9738F125526DBAB833EF2770A03AC808" xlink:to="loc_us-gaap_LongTermDebtNoncurrent_50B32518CEDE015AD6CF2770A03AB014" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_PensionAndOtherPostretirementDefinedBenefitPlansLiabilitiesNoncurrent" xlink:label="loc_us-gaap_PensionAndOtherPostretirementDefinedBenefitPlansLiabilitiesNoncurrent_4DDCD331C45F7BE2E1F52770A03AD4F8" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesNoncurrentAbstract_9738F125526DBAB833EF2770A03AC808" xlink:to="loc_us-gaap_PensionAndOtherPostretirementDefinedBenefitPlansLiabilitiesNoncurrent_4DDCD331C45F7BE2E1F52770A03AD4F8" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AccruedIncomeTaxesNoncurrent" xlink:label="loc_us-gaap_AccruedIncomeTaxesNoncurrent_C5CD0382D48BA2632F8B2770A03A2451" xlink:type="locator" />
    <definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesNoncurrentAbstract_9738F125526DBAB833EF2770A03AC808" xlink:to="loc_us-gaap_AccruedIncomeTaxesNoncurrent_C5CD0382D48BA2632F8B2770A03A2451" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_OtherLiabilitiesNoncurrent" xlink:label="loc_us-gaap_OtherLiabilitiesNoncurrent_E2AA40BCC27FF141BCED2770A03AEE0B" xlink:type="locator" />
    <definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesNoncurrentAbstract_9738F125526DBAB833EF2770A03AC808" xlink:to="loc_us-gaap_OtherLiabilitiesNoncurrent_E2AA40BCC27FF141BCED2770A03AEE0B" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LiabilitiesNoncurrent" xlink:label="loc_us-gaap_LiabilitiesNoncurrent_FA47EBAAF271E97269F02770A03ACB39" xlink:type="locator" />
    <definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesNoncurrentAbstract_9738F125526DBAB833EF2770A03AC808" xlink:to="loc_us-gaap_LiabilitiesNoncurrent_FA47EBAAF271E97269F02770A03ACB39" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterestAbstract" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterestAbstract_B6C4BA50BF685F5E8E3A2770A03A9B23" xlink:type="locator" />
    <definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_754D5E7E2845E0AE154E2770A03942A3" xlink:to="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterestAbstract_B6C4BA50BF685F5E8E3A2770A03A9B23" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CommonStockValue" xlink:label="loc_us-gaap_CommonStockValue_366C4337AB922BBFCC422770A03A0760" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterestAbstract_B6C4BA50BF685F5E8E3A2770A03A9B23" xlink:to="loc_us-gaap_CommonStockValue_366C4337AB922BBFCC422770A03A0760" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AdditionalPaidInCapitalCommonStock" xlink:label="loc_us-gaap_AdditionalPaidInCapitalCommonStock_362F6A3D262C6D7F68F02770A03AA543" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterestAbstract_B6C4BA50BF685F5E8E3A2770A03A9B23" xlink:to="loc_us-gaap_AdditionalPaidInCapitalCommonStock_362F6A3D262C6D7F68F02770A03AA543" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_RetainedEarningsAccumulatedDeficit" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_B092B64F26C1852CEE712770A03A8F6E" xlink:type="locator" />
    <definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterestAbstract_B6C4BA50BF685F5E8E3A2770A03A9B23" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_B092B64F26C1852CEE712770A03A8F6E" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CommonStockSharesHeldInEmployeeTrust" xlink:label="loc_us-gaap_CommonStockSharesHeldInEmployeeTrust_38A88D79795DF28A08312770A03A88E1" xlink:type="locator" />
    <definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterestAbstract_B6C4BA50BF685F5E8E3A2770A03A9B23" xlink:to="loc_us-gaap_CommonStockSharesHeldInEmployeeTrust_38A88D79795DF28A08312770A03A88E1" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_2823E4E56BA6896F37092770A03AD330" xlink:type="locator" />
    <definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterestAbstract_B6C4BA50BF685F5E8E3A2770A03A9B23" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_2823E4E56BA6896F37092770A03AD330" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_TreasuryStockValue" xlink:label="loc_us-gaap_TreasuryStockValue_4F84ED2CC13DFBE4CD572770A03AC7E3" xlink:type="locator" />
    <definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterestAbstract_B6C4BA50BF685F5E8E3A2770A03A9B23" xlink:to="loc_us-gaap_TreasuryStockValue_4F84ED2CC13DFBE4CD572770A03AC7E3" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_StockholdersEquity" xlink:label="loc_us-gaap_StockholdersEquity_3799D5F2EC2897AEE2452770A03A7E86" xlink:type="locator" />
    <definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterestAbstract_B6C4BA50BF685F5E8E3A2770A03A9B23" xlink:to="loc_us-gaap_StockholdersEquity_3799D5F2EC2897AEE2452770A03A7E86" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_MinorityInterest" xlink:label="loc_us-gaap_MinorityInterest_4ADD8FB863BA2C3276782770A03A67E1" xlink:type="locator" />
    <definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterestAbstract_B6C4BA50BF685F5E8E3A2770A03A9B23" xlink:to="loc_us-gaap_MinorityInterest_4ADD8FB863BA2C3276782770A03A67E1" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_CEFFE092050022AA672F2770A03B5DCE" xlink:type="locator" />
    <definitionArc order="9" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterestAbstract_B6C4BA50BF685F5E8E3A2770A03A9B23" xlink:to="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_CEFFE092050022AA672F2770A03B5DCE" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LiabilitiesAndStockholdersEquity" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_77470E0D9462A9E432E42770A03B8D91" xlink:type="locator" />
    <definitionArc order="10" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterestAbstract_B6C4BA50BF685F5E8E3A2770A03A9B23" xlink:to="loc_us-gaap_LiabilitiesAndStockholdersEquity_77470E0D9462A9E432E42770A03B8D91" xlink:type="arc" />
  </definitionLink>
  <definitionLink xlink:role="http://www.lilly.com/role/ConsolidatedCondensedBalanceSheetsParenthetical" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_61F9F6FD51A3D3EFE3A9A5DAF5C8867F" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_StatementTable" xlink:label="loc_us-gaap_StatementTable_DB2A98080EB73D7F1747A5DAF5C77BEA" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_61F9F6FD51A3D3EFE3A9A5DAF5C8867F" xlink:to="loc_us-gaap_StatementTable_DB2A98080EB73D7F1747A5DAF5C77BEA" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_StatementScenarioAxis" xlink:label="loc_us-gaap_StatementScenarioAxis_FA061E27B8424A4161D0A5DAF5C72B86" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_DB2A98080EB73D7F1747A5DAF5C77BEA" xlink:to="loc_us-gaap_StatementScenarioAxis_FA061E27B8424A4161D0A5DAF5C72B86" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ScenarioUnspecifiedDomain" xlink:label="loc_us-gaap_ScenarioUnspecifiedDomain_CF9E23F26D433E172860A5DAF5C7228A_default" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementScenarioAxis_FA061E27B8424A4161D0A5DAF5C72B86" xlink:to="loc_us-gaap_ScenarioUnspecifiedDomain_CF9E23F26D433E172860A5DAF5C7228A_default" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ScenarioUnspecifiedDomain" xlink:label="loc_us-gaap_ScenarioUnspecifiedDomain_CF9E23F26D433E172860A5DAF5C7228A" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementScenarioAxis_FA061E27B8424A4161D0A5DAF5C72B86" xlink:to="loc_us-gaap_ScenarioUnspecifiedDomain_CF9E23F26D433E172860A5DAF5C7228A" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_StatementClassOfStockAxis" xlink:label="loc_us-gaap_StatementClassOfStockAxis_0044690743F6B82A83A5A5DAF5C7F5E7" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_DB2A98080EB73D7F1747A5DAF5C77BEA" xlink:to="loc_us-gaap_StatementClassOfStockAxis_0044690743F6B82A83A5A5DAF5C7F5E7" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ClassOfStockDomain" xlink:label="loc_us-gaap_ClassOfStockDomain_F31C3D4400DAFC366E7FA5DAF5C78BE7_default" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementClassOfStockAxis_0044690743F6B82A83A5A5DAF5C7F5E7" xlink:to="loc_us-gaap_ClassOfStockDomain_F31C3D4400DAFC366E7FA5DAF5C78BE7_default" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ClassOfStockDomain" xlink:label="loc_us-gaap_ClassOfStockDomain_F31C3D4400DAFC366E7FA5DAF5C78BE7" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementClassOfStockAxis_0044690743F6B82A83A5A5DAF5C7F5E7" xlink:to="loc_us-gaap_ClassOfStockDomain_F31C3D4400DAFC366E7FA5DAF5C78BE7" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent" xlink:label="loc_us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent_79B4C4003C46EBEA300FA5DAF5C86083" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_61F9F6FD51A3D3EFE3A9A5DAF5C8867F" xlink:to="loc_us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent_79B4C4003C46EBEA300FA5DAF5C86083" xlink:type="arc" />
  </definitionLink>
  <definitionLink xlink:role="http://www.lilly.com/role/ConsolidatedCondensedStatementsOfCashFlows" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_32004ECA4635E1FDDE2B325BC1F2CA48" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_StatementTable" xlink:label="loc_us-gaap_StatementTable_2C41964549201698E0BB325BC1F21644" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_32004ECA4635E1FDDE2B325BC1F2CA48" xlink:to="loc_us-gaap_StatementTable_2C41964549201698E0BB325BC1F21644" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_StatementScenarioAxis" xlink:label="loc_us-gaap_StatementScenarioAxis_76859BB89A0D66B13EB6325BC1F224D3" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_2C41964549201698E0BB325BC1F21644" xlink:to="loc_us-gaap_StatementScenarioAxis_76859BB89A0D66B13EB6325BC1F224D3" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ScenarioUnspecifiedDomain" xlink:label="loc_us-gaap_ScenarioUnspecifiedDomain_E126EA6E0DDAB3109FCB325BC1F2470C_default" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementScenarioAxis_76859BB89A0D66B13EB6325BC1F224D3" xlink:to="loc_us-gaap_ScenarioUnspecifiedDomain_E126EA6E0DDAB3109FCB325BC1F2470C_default" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ScenarioUnspecifiedDomain" xlink:label="loc_us-gaap_ScenarioUnspecifiedDomain_E126EA6E0DDAB3109FCB325BC1F2470C" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementScenarioAxis_76859BB89A0D66B13EB6325BC1F224D3" xlink:to="loc_us-gaap_ScenarioUnspecifiedDomain_E126EA6E0DDAB3109FCB325BC1F2470C" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CashAndCashEquivalentsPeriodIncreaseDecreaseAbstract" xlink:label="loc_us-gaap_CashAndCashEquivalentsPeriodIncreaseDecreaseAbstract_760DC66BB519054858C1325BC1F25A86" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_32004ECA4635E1FDDE2B325BC1F2CA48" xlink:to="loc_us-gaap_CashAndCashEquivalentsPeriodIncreaseDecreaseAbstract_760DC66BB519054858C1325BC1F25A86" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_4FE1DF6FCE4183488701325BC1F29918" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CashAndCashEquivalentsPeriodIncreaseDecreaseAbstract_760DC66BB519054858C1325BC1F25A86" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_4FE1DF6FCE4183488701325BC1F29918" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperationsAbstract" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperationsAbstract_77B07B4F3986A39B2956325BC1F2486C" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_4FE1DF6FCE4183488701325BC1F29918" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperationsAbstract_77B07B4F3986A39B2956325BC1F2486C" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_NetIncomeLoss" xlink:label="loc_us-gaap_NetIncomeLoss_229B6792463C34380306325BC1F390E1" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperationsAbstract_77B07B4F3986A39B2956325BC1F2486C" xlink:to="loc_us-gaap_NetIncomeLoss_229B6792463C34380306325BC1F390E1" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract" xlink:label="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_733DE2682AD31968EA4E325BC1F3A231" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperationsAbstract_77B07B4F3986A39B2956325BC1F2486C" xlink:to="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_733DE2682AD31968EA4E325BC1F3A231" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DepreciationDepletionAndAmortization" xlink:label="loc_us-gaap_DepreciationDepletionAndAmortization_B126DBAE2D9D52BBBBAC325BC1F358F9" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_733DE2682AD31968EA4E325BC1F3A231" xlink:to="loc_us-gaap_DepreciationDepletionAndAmortization_B126DBAE2D9D52BBBBAC325BC1F358F9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_IncreaseDecreaseInDeferredIncomeTaxes" xlink:label="loc_us-gaap_IncreaseDecreaseInDeferredIncomeTaxes_F45A03594F4649B01417325BC1F38506" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_733DE2682AD31968EA4E325BC1F3A231" xlink:to="loc_us-gaap_IncreaseDecreaseInDeferredIncomeTaxes_F45A03594F4649B01417325BC1F38506" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ShareBasedCompensation" xlink:label="loc_us-gaap_ShareBasedCompensation_A1B4D176AE0A98866002325BC1F30155" xlink:type="locator" />
    <definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_733DE2682AD31968EA4E325BC1F3A231" xlink:to="loc_us-gaap_ShareBasedCompensation_A1B4D176AE0A98866002325BC1F30155" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_PaymentsforProceedsfromHedgeOperatingActivities" xlink:label="loc_lly_PaymentsforProceedsfromHedgeOperatingActivities_857F9FF14248BD0AF7AA325BC1F3EFB4" xlink:type="locator" />
    <definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_733DE2682AD31968EA4E325BC1F3A231" xlink:to="loc_lly_PaymentsforProceedsfromHedgeOperatingActivities_857F9FF14248BD0AF7AA325BC1F3EFB4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_PaymentsToAcquireInProcessResearchAndDevelopment" xlink:label="loc_us-gaap_PaymentsToAcquireInProcessResearchAndDevelopment_C4A067CB6831EA1906D5325BC1F3974D" xlink:type="locator" />
    <definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_733DE2682AD31968EA4E325BC1F3A231" xlink:to="loc_us-gaap_PaymentsToAcquireInProcessResearchAndDevelopment_C4A067CB6831EA1906D5325BC1F3974D" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_IncreaseDecreaseInOtherOperatingCapitalNet" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherOperatingCapitalNet_80BB67F21669D9DBC063325BC1F35548" xlink:type="locator" />
    <definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_733DE2682AD31968EA4E325BC1F3A231" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherOperatingCapitalNet_80BB67F21669D9DBC063325BC1F35548" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_OtherOperatingActivitiesCashFlowStatement" xlink:label="loc_us-gaap_OtherOperatingActivitiesCashFlowStatement_A1CFEF30ED7B5DFE308D325BC1F3FA8C" xlink:type="locator" />
    <definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_733DE2682AD31968EA4E325BC1F3A231" xlink:to="loc_us-gaap_OtherOperatingActivitiesCashFlowStatement_A1CFEF30ED7B5DFE308D325BC1F3FA8C" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_4D47EB7E57554760088E325BC1F34FCA" xlink:type="locator" />
    <definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_733DE2682AD31968EA4E325BC1F3A231" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_4D47EB7E57554760088E325BC1F34FCA" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_A4088EF9D18BE08262B0325BC1F30A86" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CashAndCashEquivalentsPeriodIncreaseDecreaseAbstract_760DC66BB519054858C1325BC1F25A86" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_A4088EF9D18BE08262B0325BC1F30A86" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperationsAbstract" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperationsAbstract_74C3F9E3DFB9D0302742325BC1F3FB4C" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_A4088EF9D18BE08262B0325BC1F30A86" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperationsAbstract_74C3F9E3DFB9D0302742325BC1F3FB4C" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_PaymentsForProceedsFromProductiveAssets" xlink:label="loc_us-gaap_PaymentsForProceedsFromProductiveAssets_320E60435FCE4703126A325BC1F37813" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperationsAbstract_74C3F9E3DFB9D0302742325BC1F3FB4C" xlink:to="loc_us-gaap_PaymentsForProceedsFromProductiveAssets_320E60435FCE4703126A325BC1F37813" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ProceedsFromSaleOfShortTermInvestments" xlink:label="loc_us-gaap_ProceedsFromSaleOfShortTermInvestments_F477B49A4A80CB96CE2A325BC1F3F59A" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperationsAbstract_74C3F9E3DFB9D0302742325BC1F3FB4C" xlink:to="loc_us-gaap_ProceedsFromSaleOfShortTermInvestments_F477B49A4A80CB96CE2A325BC1F3F59A" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_PaymentsToAcquireShortTermInvestments" xlink:label="loc_us-gaap_PaymentsToAcquireShortTermInvestments_634367EC006EFB2E6BC9325BC1F38CF6" xlink:type="locator" />
    <definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperationsAbstract_74C3F9E3DFB9D0302742325BC1F3FB4C" xlink:to="loc_us-gaap_PaymentsToAcquireShortTermInvestments_634367EC006EFB2E6BC9325BC1F38CF6" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ProceedsFromSaleOfLongtermInvestments" xlink:label="loc_us-gaap_ProceedsFromSaleOfLongtermInvestments_7E06C2F9E927EEEA4068325BC1F384E1" xlink:type="locator" />
    <definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperationsAbstract_74C3F9E3DFB9D0302742325BC1F3FB4C" xlink:to="loc_us-gaap_ProceedsFromSaleOfLongtermInvestments_7E06C2F9E927EEEA4068325BC1F384E1" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_PaymentsToAcquireLongtermInvestments" xlink:label="loc_us-gaap_PaymentsToAcquireLongtermInvestments_1A529C1E8413F6A66507325BC1F37453" xlink:type="locator" />
    <definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperationsAbstract_74C3F9E3DFB9D0302742325BC1F3FB4C" xlink:to="loc_us-gaap_PaymentsToAcquireLongtermInvestments_1A529C1E8413F6A66507325BC1F37453" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_IncreaseDecreaseInRestrictedCash" xlink:label="loc_us-gaap_IncreaseDecreaseInRestrictedCash_0CCF1018AC6EC8DF111F325BC1F34E32" xlink:type="locator" />
    <definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperationsAbstract_74C3F9E3DFB9D0302742325BC1F3FB4C" xlink:to="loc_us-gaap_IncreaseDecreaseInRestrictedCash_0CCF1018AC6EC8DF111F325BC1F34E32" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired" xlink:label="loc_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_83BECA2BB74857FDD93D325BC1F4F756" xlink:type="locator" />
    <definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperationsAbstract_74C3F9E3DFB9D0302742325BC1F3FB4C" xlink:to="loc_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_83BECA2BB74857FDD93D325BC1F4F756" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ProceedsFromSaleOfProductiveAssets" xlink:label="loc_us-gaap_ProceedsFromSaleOfProductiveAssets_A149126401C4716007D3325BC1F47A09" xlink:type="locator" />
    <definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperationsAbstract_74C3F9E3DFB9D0302742325BC1F3FB4C" xlink:to="loc_us-gaap_ProceedsFromSaleOfProductiveAssets_A149126401C4716007D3325BC1F47A09" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_PurchasedInProcessResearchAndDevelopment" xlink:label="loc_lly_PurchasedInProcessResearchAndDevelopment_17CBE1AA7E65A52A6454325BC1F4D62E" xlink:type="locator" />
    <definitionArc order="9" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperationsAbstract_74C3F9E3DFB9D0302742325BC1F3FB4C" xlink:to="loc_lly_PurchasedInProcessResearchAndDevelopment_17CBE1AA7E65A52A6454325BC1F4D62E" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_PaymentsToAcquireIntangibleAssets" xlink:label="loc_us-gaap_PaymentsToAcquireIntangibleAssets_6D69BBE154B0011C9B79325BC1F46BB0" xlink:type="locator" />
    <definitionArc order="10" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperationsAbstract_74C3F9E3DFB9D0302742325BC1F3FB4C" xlink:to="loc_us-gaap_PaymentsToAcquireIntangibleAssets_6D69BBE154B0011C9B79325BC1F46BB0" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_PaymentsForProceedsFromOtherInvestingActivities" xlink:label="loc_us-gaap_PaymentsForProceedsFromOtherInvestingActivities_48B4879DC26ABF6AAEB6325BC1F453E2" xlink:type="locator" />
    <definitionArc order="11" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperationsAbstract_74C3F9E3DFB9D0302742325BC1F3FB4C" xlink:to="loc_us-gaap_PaymentsForProceedsFromOtherInvestingActivities_48B4879DC26ABF6AAEB6325BC1F453E2" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_6EFAD016576FCBB1371B325BC1F495EB" xlink:type="locator" />
    <definitionArc order="12" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperationsAbstract_74C3F9E3DFB9D0302742325BC1F3FB4C" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_6EFAD016576FCBB1371B325BC1F495EB" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_154DD6733A32272FE112325BC1F4E151" xlink:type="locator" />
    <definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CashAndCashEquivalentsPeriodIncreaseDecreaseAbstract_760DC66BB519054858C1325BC1F25A86" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_154DD6733A32272FE112325BC1F4E151" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperationsAbstract" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperationsAbstract_D535672B754B33159ECF325BC1F49264" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_154DD6733A32272FE112325BC1F4E151" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperationsAbstract_D535672B754B33159ECF325BC1F49264" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_PaymentsOfDividends" xlink:label="loc_us-gaap_PaymentsOfDividends_D46722937BAD35CB42CD325BC1F42C84" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperationsAbstract_D535672B754B33159ECF325BC1F49264" xlink:to="loc_us-gaap_PaymentsOfDividends_D46722937BAD35CB42CD325BC1F42C84" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ProceedsFromRepaymentsOfShortTermDebt" xlink:label="loc_us-gaap_ProceedsFromRepaymentsOfShortTermDebt_80DDAF3F9A0B7A373A6D325BC1F459B2" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperationsAbstract_D535672B754B33159ECF325BC1F49264" xlink:to="loc_us-gaap_ProceedsFromRepaymentsOfShortTermDebt_80DDAF3F9A0B7A373A6D325BC1F459B2" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ProceedsFromIssuanceOfLongTermDebt" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfLongTermDebt_E1DD81BE0D9550BBE099325BC1F48D9A" xlink:type="locator" />
    <definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperationsAbstract_D535672B754B33159ECF325BC1F49264" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfLongTermDebt_E1DD81BE0D9550BBE099325BC1F48D9A" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_RepaymentsOfLongTermDebt" xlink:label="loc_us-gaap_RepaymentsOfLongTermDebt_AD95BD2B36712E352584325BC1F56FF6" xlink:type="locator" />
    <definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperationsAbstract_D535672B754B33159ECF325BC1F49264" xlink:to="loc_us-gaap_RepaymentsOfLongTermDebt_AD95BD2B36712E352584325BC1F56FF6" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_PaymentsForRepurchaseOfCommonStock" xlink:label="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_48B359E60A91EAB30B1B325BC1F5FE5C" xlink:type="locator" />
    <definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperationsAbstract_D535672B754B33159ECF325BC1F49264" xlink:to="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_48B359E60A91EAB30B1B325BC1F5FE5C" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ProceedsFromPaymentsForOtherFinancingActivities" xlink:label="loc_us-gaap_ProceedsFromPaymentsForOtherFinancingActivities_7EA7A87699A69B774E3D325BC1F5271C" xlink:type="locator" />
    <definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperationsAbstract_D535672B754B33159ECF325BC1F49264" xlink:to="loc_us-gaap_ProceedsFromPaymentsForOtherFinancingActivities_7EA7A87699A69B774E3D325BC1F5271C" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_E75FF17C68C6FA413BAB325BC1F5EBF7" xlink:type="locator" />
    <definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperationsAbstract_D535672B754B33159ECF325BC1F49264" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_E75FF17C68C6FA413BAB325BC1F5EBF7" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_EffectOfExchangeRateOnCashAndCashEquivalents" xlink:label="loc_us-gaap_EffectOfExchangeRateOnCashAndCashEquivalents_BA26E1227D4029092FCA325BC1F52354" xlink:type="locator" />
    <definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CashAndCashEquivalentsPeriodIncreaseDecreaseAbstract_760DC66BB519054858C1325BC1F25A86" xlink:to="loc_us-gaap_EffectOfExchangeRateOnCashAndCashEquivalents_BA26E1227D4029092FCA325BC1F52354" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CashAndCashEquivalentsPeriodIncreaseDecrease" xlink:label="loc_us-gaap_CashAndCashEquivalentsPeriodIncreaseDecrease_09E9693439A3444FBC81325BC1F534AF" xlink:type="locator" />
    <definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CashAndCashEquivalentsPeriodIncreaseDecreaseAbstract_760DC66BB519054858C1325BC1F25A86" xlink:to="loc_us-gaap_CashAndCashEquivalentsPeriodIncreaseDecrease_09E9693439A3444FBC81325BC1F534AF" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_A69BFAFD889D3BEFA69E325BC1F57A40" xlink:type="locator" />
    <definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CashAndCashEquivalentsPeriodIncreaseDecreaseAbstract_760DC66BB519054858C1325BC1F25A86" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_A69BFAFD889D3BEFA69E325BC1F57A40" xlink:type="arc" />
  </definitionLink>
  <definitionLink xlink:role="http://www.lilly.com/role/ConsolidatedCondensedStatementsOfComprehensiveIncome" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_F6A7BBA9F24C3CEFB5C928BAA06A7071" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_StatementTable" xlink:label="loc_us-gaap_StatementTable_0C83298893DEF661BE8628BAA06AD847" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_F6A7BBA9F24C3CEFB5C928BAA06A7071" xlink:to="loc_us-gaap_StatementTable_0C83298893DEF661BE8628BAA06AD847" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_StatementScenarioAxis" xlink:label="loc_us-gaap_StatementScenarioAxis_BCE8D2D78262C852AE4928BAA06A7944" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_0C83298893DEF661BE8628BAA06AD847" xlink:to="loc_us-gaap_StatementScenarioAxis_BCE8D2D78262C852AE4928BAA06A7944" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ScenarioUnspecifiedDomain" xlink:label="loc_us-gaap_ScenarioUnspecifiedDomain_27FA3E0030AF9964C64528BAA06A2E81_default" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementScenarioAxis_BCE8D2D78262C852AE4928BAA06A7944" xlink:to="loc_us-gaap_ScenarioUnspecifiedDomain_27FA3E0030AF9964C64528BAA06A2E81_default" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ScenarioUnspecifiedDomain" xlink:label="loc_us-gaap_ScenarioUnspecifiedDomain_27FA3E0030AF9964C64528BAA06A2E81" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementScenarioAxis_BCE8D2D78262C852AE4928BAA06A7944" xlink:to="loc_us-gaap_ScenarioUnspecifiedDomain_27FA3E0030AF9964C64528BAA06A2E81" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_NetIncomeLoss" xlink:label="loc_us-gaap_NetIncomeLoss_E871424F08F0F1DF06E128BAA06A9CF5" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_F6A7BBA9F24C3CEFB5C928BAA06A7071" xlink:to="loc_us-gaap_NetIncomeLoss_E871424F08F0F1DF06E128BAA06A9CF5" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_66AEB886A35F709212B928BAA06AB6B4" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_F6A7BBA9F24C3CEFB5C928BAA06A7071" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_66AEB886A35F709212B928BAA06AB6B4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ComprehensiveIncomeNetOfTax" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_74DD999C2A33C048A0D228BAA06AE1D3" xlink:type="locator" />
    <definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_F6A7BBA9F24C3CEFB5C928BAA06A7071" xlink:to="loc_us-gaap_ComprehensiveIncomeNetOfTax_74DD999C2A33C048A0D228BAA06AE1D3" xlink:type="arc" />
  </definitionLink>
  <definitionLink xlink:role="http://www.lilly.com/role/ConsolidatedCondensedStatementsOfOperations" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_1A817B4160296B1AB0EF5A706C24FAC3" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_StatementTable" xlink:label="loc_us-gaap_StatementTable_75AE9AA0638249C5D8365A706C22417F" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_1A817B4160296B1AB0EF5A706C24FAC3" xlink:to="loc_us-gaap_StatementTable_75AE9AA0638249C5D8365A706C22417F" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_StatementScenarioAxis" xlink:label="loc_us-gaap_StatementScenarioAxis_6694182ED2C90F250E7E5A706C238D59" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_75AE9AA0638249C5D8365A706C22417F" xlink:to="loc_us-gaap_StatementScenarioAxis_6694182ED2C90F250E7E5A706C238D59" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ScenarioUnspecifiedDomain" xlink:label="loc_us-gaap_ScenarioUnspecifiedDomain_330ADD2C893E8901446F5A706C23C691_default" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementScenarioAxis_6694182ED2C90F250E7E5A706C238D59" xlink:to="loc_us-gaap_ScenarioUnspecifiedDomain_330ADD2C893E8901446F5A706C23C691_default" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ScenarioUnspecifiedDomain" xlink:label="loc_us-gaap_ScenarioUnspecifiedDomain_330ADD2C893E8901446F5A706C23C691" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementScenarioAxis_6694182ED2C90F250E7E5A706C238D59" xlink:to="loc_us-gaap_ScenarioUnspecifiedDomain_330ADD2C893E8901446F5A706C23C691" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_Revenues" xlink:label="loc_us-gaap_Revenues_4A372E40EB8BC507B3C85A706C248406" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_1A817B4160296B1AB0EF5A706C24FAC3" xlink:to="loc_us-gaap_Revenues_4A372E40EB8BC507B3C85A706C248406" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CostsAndExpensesAbstract" xlink:label="loc_us-gaap_CostsAndExpensesAbstract_F7A5ACA0B6FDEE463EB85A706C25766F" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_1A817B4160296B1AB0EF5A706C24FAC3" xlink:to="loc_us-gaap_CostsAndExpensesAbstract_F7A5ACA0B6FDEE463EB85A706C25766F" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CostOfGoodsSold" xlink:label="loc_us-gaap_CostOfGoodsSold_A32A4F01FF58437AACEF5A706C25D04D" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CostsAndExpensesAbstract_F7A5ACA0B6FDEE463EB85A706C25766F" xlink:to="loc_us-gaap_CostOfGoodsSold_A32A4F01FF58437AACEF5A706C25D04D" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ResearchAndDevelopmentExpense" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_E7D58537D95096597D7B5A706C25D2C1" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CostsAndExpensesAbstract_F7A5ACA0B6FDEE463EB85A706C25766F" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_E7D58537D95096597D7B5A706C25D2C1" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SellingGeneralAndAdministrativeExpense" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpense_562836453A56B49DD7DF5A706C2619D2" xlink:type="locator" />
    <definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CostsAndExpensesAbstract_F7A5ACA0B6FDEE463EB85A706C25766F" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpense_562836453A56B49DD7DF5A706C2619D2" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_AcquiredInProcessResearchAndDevelopment" xlink:label="loc_lly_AcquiredInProcessResearchAndDevelopment_CF670B01B974AE3974845A706C2682C3" xlink:type="locator" />
    <definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CostsAndExpensesAbstract_F7A5ACA0B6FDEE463EB85A706C25766F" xlink:to="loc_lly_AcquiredInProcessResearchAndDevelopment_CF670B01B974AE3974845A706C2682C3" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_RestructuringSettlementAndImpairmentProvisions" xlink:label="loc_us-gaap_RestructuringSettlementAndImpairmentProvisions_089D5DEF48A21FDF1A3F5A706C2624A4" xlink:type="locator" />
    <definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CostsAndExpensesAbstract_F7A5ACA0B6FDEE463EB85A706C25766F" xlink:to="loc_us-gaap_RestructuringSettlementAndImpairmentProvisions_089D5DEF48A21FDF1A3F5A706C2624A4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_NonoperatingIncomeExpense" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_CC9E2CCD29A44B1747355A706C26295D" xlink:type="locator" />
    <definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CostsAndExpensesAbstract_F7A5ACA0B6FDEE463EB85A706C25766F" xlink:to="loc_us-gaap_NonoperatingIncomeExpense_CC9E2CCD29A44B1747355A706C26295D" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_CostOfSalesOperatingExpensesAndOtherNet" xlink:label="loc_lly_CostOfSalesOperatingExpensesAndOtherNet_AC08519BEB1CB73344805A706C307FD0" xlink:type="locator" />
    <definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_1A817B4160296B1AB0EF5A706C24FAC3" xlink:to="loc_lly_CostOfSalesOperatingExpensesAndOtherNet_AC08519BEB1CB73344805A706C307FD0" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_BA55179C031B15C166E45A706C30E409" xlink:type="locator" />
    <definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_1A817B4160296B1AB0EF5A706C24FAC3" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_BA55179C031B15C166E45A706C30E409" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_IncomeTaxExpenseBenefit" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_C03E348161D506F820925A706C3053A0" xlink:type="locator" />
    <definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_1A817B4160296B1AB0EF5A706C24FAC3" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_C03E348161D506F820925A706C3053A0" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_NetIncomeLoss" xlink:label="loc_us-gaap_NetIncomeLoss_8E6DD4CC2D719548FB355A706C3091CE" xlink:type="locator" />
    <definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_1A817B4160296B1AB0EF5A706C24FAC3" xlink:to="loc_us-gaap_NetIncomeLoss_8E6DD4CC2D719548FB355A706C3091CE" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_EarningsPerShareAbstract" xlink:label="loc_us-gaap_EarningsPerShareAbstract_591B3D6516BB2B1C90305A706C3061F9" xlink:type="locator" />
    <definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_1A817B4160296B1AB0EF5A706C24FAC3" xlink:to="loc_us-gaap_EarningsPerShareAbstract_591B3D6516BB2B1C90305A706C3061F9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_EarningsPerShareBasic" xlink:label="loc_us-gaap_EarningsPerShareBasic_E8082004795766575E215A706C3A9D4E" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EarningsPerShareAbstract_591B3D6516BB2B1C90305A706C3061F9" xlink:to="loc_us-gaap_EarningsPerShareBasic_E8082004795766575E215A706C3A9D4E" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_EarningsPerShareDiluted" xlink:label="loc_us-gaap_EarningsPerShareDiluted_EAC6ADD62C91D098D6205A706C3AD7D0" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EarningsPerShareAbstract_591B3D6516BB2B1C90305A706C3061F9" xlink:to="loc_us-gaap_EarningsPerShareDiluted_EAC6ADD62C91D098D6205A706C3AD7D0" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingAbstract" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingAbstract_7C1B3F51268DD6A7B54A5A706C3A93F0" xlink:type="locator" />
    <definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_1A817B4160296B1AB0EF5A706C24FAC3" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingAbstract_7C1B3F51268DD6A7B54A5A706C3A93F0" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingBasic" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_3A4162178E87465B88205A706C3AB94B" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingAbstract_7C1B3F51268DD6A7B54A5A706C3A93F0" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_3A4162178E87465B88205A706C3AB94B" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding" xlink:label="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_170628404DE5F1723F215A706C3A4722" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingAbstract_7C1B3F51268DD6A7B54A5A706C3A93F0" xlink:to="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_170628404DE5F1723F215A706C3A4722" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CommonStockDividendsPerShareCashPaid" xlink:label="loc_us-gaap_CommonStockDividendsPerShareCashPaid_A0D5428C649E19648F535A706C3A1444" xlink:type="locator" />
    <definitionArc order="9" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_1A817B4160296B1AB0EF5A706C24FAC3" xlink:to="loc_us-gaap_CommonStockDividendsPerShareCashPaid_A0D5428C649E19648F535A706C3A1444" xlink:type="arc" />
  </definitionLink>
  <definitionLink xlink:role="http://www.lilly.com/role/Contingencies" xlink:type="extended" />
  <definitionLink xlink:role="http://www.lilly.com/role/ContingenciesDetails" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_760E6EA6C9147196AFDE325BEDA4CAB0" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LossContingenciesTable" xlink:label="loc_us-gaap_LossContingenciesTable_960A9114068B9B873E5E325BED9C90B2" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_760E6EA6C9147196AFDE325BEDA4CAB0" xlink:to="loc_us-gaap_LossContingenciesTable_960A9114068B9B873E5E325BED9C90B2" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LitigationCaseAxis" xlink:label="loc_us-gaap_LitigationCaseAxis_BE3E4933DF12C1F963BA325BED9CF32E" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_LossContingenciesTable_960A9114068B9B873E5E325BED9C90B2" xlink:to="loc_us-gaap_LitigationCaseAxis_BE3E4933DF12C1F963BA325BED9CF32E" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LitigationCaseTypeDomain" xlink:label="loc_us-gaap_LitigationCaseTypeDomain_290D063A3CCB644328E2325BED9C2120_default" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LitigationCaseAxis_BE3E4933DF12C1F963BA325BED9CF32E" xlink:to="loc_us-gaap_LitigationCaseTypeDomain_290D063A3CCB644328E2325BED9C2120_default" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LitigationCaseTypeDomain" xlink:label="loc_us-gaap_LitigationCaseTypeDomain_290D063A3CCB644328E2325BED9C2120" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LitigationCaseAxis_BE3E4933DF12C1F963BA325BED9CF32E" xlink:to="loc_us-gaap_LitigationCaseTypeDomain_290D063A3CCB644328E2325BED9C2120" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_MultiDistrictLitigationMdlMember" xlink:label="loc_lly_MultiDistrictLitigationMdlMember_79882057971F2D8A4F94325BED9C7418" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LitigationCaseTypeDomain_290D063A3CCB644328E2325BED9C2120" xlink:to="loc_lly_MultiDistrictLitigationMdlMember_79882057971F2D8A4F94325BED9C7418" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_ProductLiabilityLitigationMember" xlink:label="loc_lly_ProductLiabilityLitigationMember_03871FEACBD4965738A4325BED9C4BE4" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LitigationCaseTypeDomain_290D063A3CCB644328E2325BED9C2120" xlink:to="loc_lly_ProductLiabilityLitigationMember_03871FEACBD4965738A4325BED9C4BE4" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_LillyPortionMember" xlink:label="loc_lly_LillyPortionMember_4D08FDC5E1E183DF6CDA325BED9C1B22" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lly_ProductLiabilityLitigationMember_03871FEACBD4965738A4325BED9C4BE4" xlink:to="loc_lly_LillyPortionMember_4D08FDC5E1E183DF6CDA325BED9C1B22" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_TakedaPortionMember" xlink:label="loc_lly_TakedaPortionMember_7CA9D4B46DD19DBA8DAB325BED9C9628" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lly_ProductLiabilityLitigationMember_03871FEACBD4965738A4325BED9C4BE4" xlink:to="loc_lly_TakedaPortionMember_7CA9D4B46DD19DBA8DAB325BED9C9628" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_EmployeeLitigationMember" xlink:label="loc_lly_EmployeeLitigationMember_DF411BE72D9222495FFA325BED9C1591" xlink:type="locator" />
    <definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LitigationCaseTypeDomain_290D063A3CCB644328E2325BED9C2120" xlink:to="loc_lly_EmployeeLitigationMember_DF411BE72D9222495FFA325BED9C1591" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_StatementGeographicalAxis" xlink:label="loc_us-gaap_StatementGeographicalAxis_3480700E4813FFDC0F96325BED9DF498" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_LossContingenciesTable_960A9114068B9B873E5E325BED9C90B2" xlink:to="loc_us-gaap_StatementGeographicalAxis_3480700E4813FFDC0F96325BED9DF498" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SegmentGeographicalDomain" xlink:label="loc_us-gaap_SegmentGeographicalDomain_762CD57B9F64A4E8A6FF325BED9DB833_default" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementGeographicalAxis_3480700E4813FFDC0F96325BED9DF498" xlink:to="loc_us-gaap_SegmentGeographicalDomain_762CD57B9F64A4E8A6FF325BED9DB833_default" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SegmentGeographicalDomain" xlink:label="loc_us-gaap_SegmentGeographicalDomain_762CD57B9F64A4E8A6FF325BED9DB833" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementGeographicalAxis_3480700E4813FFDC0F96325BED9DF498" xlink:to="loc_us-gaap_SegmentGeographicalDomain_762CD57B9F64A4E8A6FF325BED9DB833" xlink:type="arc" />
    <loc xlink:href="http://xbrl.sec.gov/country/2016/country-2016-01-31.xsd#country_CA" xlink:label="loc_country_CA_97180A983EF5A669A275325BED9DAC6C" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentGeographicalDomain_762CD57B9F64A4E8A6FF325BED9DB833" xlink:to="loc_country_CA_97180A983EF5A669A275325BED9DAC6C" xlink:type="arc" />
    <loc xlink:href="http://xbrl.sec.gov/stpr/2011/stpr-2011-01-31.xsd#stpr_A6" xlink:label="loc_stpr_A6_46FBFDAADB10EF697B69325BED9D6A72" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentGeographicalDomain_762CD57B9F64A4E8A6FF325BED9DB833" xlink:to="loc_stpr_A6_46FBFDAADB10EF697B69325BED9D6A72" xlink:type="arc" />
    <loc xlink:href="http://xbrl.sec.gov/stpr/2011/stpr-2011-01-31.xsd#stpr_A8" xlink:label="loc_stpr_A8_75F3F7D8D2EE24911903325BED9D5FB2" xlink:type="locator" />
    <definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentGeographicalDomain_762CD57B9F64A4E8A6FF325BED9DB833" xlink:to="loc_stpr_A8_75F3F7D8D2EE24911903325BED9D5FB2" xlink:type="arc" />
    <loc xlink:href="http://xbrl.sec.gov/stpr/2011/stpr-2011-01-31.xsd#stpr_A0" xlink:label="loc_stpr_A0_406E756F1E3E2146909D325BED9EE496" xlink:type="locator" />
    <definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentGeographicalDomain_762CD57B9F64A4E8A6FF325BED9DB833" xlink:to="loc_stpr_A0_406E756F1E3E2146909D325BED9EE496" xlink:type="arc" />
    <loc xlink:href="http://xbrl.sec.gov/stpr/2011/stpr-2011-01-31.xsd#stpr_CA" xlink:label="loc_stpr_CA_12088DB56C8D4D86B82A325BED9ECFD2" xlink:type="locator" />
    <definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentGeographicalDomain_762CD57B9F64A4E8A6FF325BED9DB833" xlink:to="loc_stpr_CA_12088DB56C8D4D86B82A325BED9ECFD2" xlink:type="arc" />
    <loc xlink:href="http://xbrl.sec.gov/country/2016/country-2016-01-31.xsd#country_BR" xlink:label="loc_country_BR_F9DFF27AD59EB2F56930325BED9EA873" xlink:type="locator" />
    <definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentGeographicalDomain_762CD57B9F64A4E8A6FF325BED9DB833" xlink:to="loc_country_BR_F9DFF27AD59EB2F56930325BED9EA873" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_OtherstatesMember" xlink:label="loc_lly_OtherstatesMember_B6E681C445A8BCFF17B6325BEDA32DD0" xlink:type="locator" />
    <definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentGeographicalDomain_762CD57B9F64A4E8A6FF325BED9DB833" xlink:to="loc_lly_OtherstatesMember_B6E681C445A8BCFF17B6325BEDA32DD0" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LossContingenciesByNatureOfContingencyAxis" xlink:label="loc_us-gaap_LossContingenciesByNatureOfContingencyAxis_3E0C0BB2828D2B8ACB5F325BEDA3B833" xlink:type="locator" />
    <definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_LossContingenciesTable_960A9114068B9B873E5E325BED9C90B2" xlink:to="loc_us-gaap_LossContingenciesByNatureOfContingencyAxis_3E0C0BB2828D2B8ACB5F325BEDA3B833" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LossContingencyNatureDomain" xlink:label="loc_us-gaap_LossContingencyNatureDomain_F7105D0210548E50D28B325BEDA39FDC_default" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LossContingenciesByNatureOfContingencyAxis_3E0C0BB2828D2B8ACB5F325BEDA3B833" xlink:to="loc_us-gaap_LossContingencyNatureDomain_F7105D0210548E50D28B325BEDA39FDC_default" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LossContingencyNatureDomain" xlink:label="loc_us-gaap_LossContingencyNatureDomain_F7105D0210548E50D28B325BEDA39FDC" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LossContingenciesByNatureOfContingencyAxis_3E0C0BB2828D2B8ACB5F325BEDA3B833" xlink:to="loc_us-gaap_LossContingencyNatureDomain_F7105D0210548E50D28B325BEDA39FDC" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_DamagesfromProductCancerMember" xlink:label="loc_lly_DamagesfromProductCancerMember_0A85A008AD79CE234963325BEDA35EA4" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingencyNatureDomain_F7105D0210548E50D28B325BEDA39FDC" xlink:to="loc_lly_DamagesfromProductCancerMember_0A85A008AD79CE234963325BEDA35EA4" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_CompensatoryDamagesMember" xlink:label="loc_lly_CompensatoryDamagesMember_0EB35F7CA2DC94D71894325BEDA3EDD5" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingencyNatureDomain_F7105D0210548E50D28B325BEDA39FDC" xlink:to="loc_lly_CompensatoryDamagesMember_0EB35F7CA2DC94D71894325BEDA3EDD5" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_PunitiveDamagesMember" xlink:label="loc_lly_PunitiveDamagesMember_F8A45F8132B28E3D85BE325BEDA32AB7" xlink:type="locator" />
    <definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingencyNatureDomain_F7105D0210548E50D28B325BEDA39FDC" xlink:to="loc_lly_PunitiveDamagesMember_F8A45F8132B28E3D85BE325BEDA32AB7" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_ProductLiabilityLitigationMember" xlink:label="loc_lly_ProductLiabilityLitigationMember_58EF22F40E5231208C1E325BEDA35BEB" xlink:type="locator" />
    <definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingencyNatureDomain_F7105D0210548E50D28B325BEDA39FDC" xlink:to="loc_lly_ProductLiabilityLitigationMember_58EF22F40E5231208C1E325BEDA35BEB" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ProductOrServiceAxis" xlink:label="loc_us-gaap_ProductOrServiceAxis_7566AB42AB6FB26F94C8325BEDA3010F" xlink:type="locator" />
    <definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_LossContingenciesTable_960A9114068B9B873E5E325BED9C90B2" xlink:to="loc_us-gaap_ProductOrServiceAxis_7566AB42AB6FB26F94C8325BEDA3010F" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ProductsAndServicesDomain" xlink:label="loc_us-gaap_ProductsAndServicesDomain_81613218ED7B19968CAB325BEDA380AB_default" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ProductOrServiceAxis_7566AB42AB6FB26F94C8325BEDA3010F" xlink:to="loc_us-gaap_ProductsAndServicesDomain_81613218ED7B19968CAB325BEDA380AB_default" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ProductsAndServicesDomain" xlink:label="loc_us-gaap_ProductsAndServicesDomain_81613218ED7B19968CAB325BEDA380AB" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ProductOrServiceAxis_7566AB42AB6FB26F94C8325BEDA3010F" xlink:to="loc_us-gaap_ProductsAndServicesDomain_81613218ED7B19968CAB325BEDA380AB" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_ByettaMember" xlink:label="loc_lly_ByettaMember_5B6C78700D7ABFE9E780325BEDA3DC4B" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ProductsAndServicesDomain_81613218ED7B19968CAB325BEDA380AB" xlink:to="loc_lly_ByettaMember_5B6C78700D7ABFE9E780325BEDA3DC4B" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_CymbaltaMember" xlink:label="loc_lly_CymbaltaMember_29E6B7C958D027AF1D31325BEDA31E8F" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ProductsAndServicesDomain_81613218ED7B19968CAB325BEDA380AB" xlink:to="loc_lly_CymbaltaMember_29E6B7C958D027AF1D31325BEDA31E8F" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_ProzacMember" xlink:label="loc_lly_ProzacMember_C6A3AC831B28B11E7F07325BEDA459FE" xlink:type="locator" />
    <definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ProductsAndServicesDomain_81613218ED7B19968CAB325BEDA380AB" xlink:to="loc_lly_ProzacMember_C6A3AC831B28B11E7F07325BEDA459FE" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_ActosMember" xlink:label="loc_lly_ActosMember_26B0FAE6A5894B4B7506325BEDA487D9" xlink:type="locator" />
    <definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ProductsAndServicesDomain_81613218ED7B19968CAB325BEDA380AB" xlink:to="loc_lly_ActosMember_26B0FAE6A5894B4B7506325BEDA487D9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SubsequentEventTypeAxis" xlink:label="loc_us-gaap_SubsequentEventTypeAxis_B39EB3B12C91C4DDDCD0325BEDA4E6AC" xlink:type="locator" />
    <definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_LossContingenciesTable_960A9114068B9B873E5E325BED9C90B2" xlink:to="loc_us-gaap_SubsequentEventTypeAxis_B39EB3B12C91C4DDDCD0325BEDA4E6AC" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SubsequentEventTypeDomain" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_6BA4E95B6DA853D9F261325BEDA4B775_default" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_B39EB3B12C91C4DDDCD0325BEDA4E6AC" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_6BA4E95B6DA853D9F261325BEDA4B775_default" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SubsequentEventTypeDomain" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_6BA4E95B6DA853D9F261325BEDA4B775" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_B39EB3B12C91C4DDDCD0325BEDA4E6AC" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_6BA4E95B6DA853D9F261325BEDA4B775" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SubsequentEventMember" xlink:label="loc_us-gaap_SubsequentEventMember_0580CBAE1EC9619FCBC2325BEDA4274B" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsequentEventTypeDomain_6BA4E95B6DA853D9F261325BEDA4B775" xlink:to="loc_us-gaap_SubsequentEventMember_0580CBAE1EC9619FCBC2325BEDA4274B" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_LossContingencyNumberOfLawsuits" xlink:label="loc_lly_LossContingencyNumberOfLawsuits_1F6C06176DA1F606E378325BEDA49715" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_760E6EA6C9147196AFDE325BEDA4CAB0" xlink:to="loc_lly_LossContingencyNumberOfLawsuits_1F6C06176DA1F606E378325BEDA49715" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LossContingencyNumberOfPlaintiffs" xlink:label="loc_us-gaap_LossContingencyNumberOfPlaintiffs_8CAB7D5EFC9FA31B3FF6325BEDA4EB50" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_760E6EA6C9147196AFDE325BEDA4CAB0" xlink:to="loc_us-gaap_LossContingencyNumberOfPlaintiffs_8CAB7D5EFC9FA31B3FF6325BEDA4EB50" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_LossContingencyNumberOfClaimants" xlink:label="loc_lly_LossContingencyNumberOfClaimants_65DD650B8034D3325F8D325BEDA4BAAA" xlink:type="locator" />
    <definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_760E6EA6C9147196AFDE325BEDA4CAB0" xlink:to="loc_lly_LossContingencyNumberOfClaimants_65DD650B8034D3325F8D325BEDA4BAAA" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_LossContingencyNumberOfCases" xlink:label="loc_lly_LossContingencyNumberOfCases_AECE5201440CC259F090325BEDA9C0BE" xlink:type="locator" />
    <definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_760E6EA6C9147196AFDE325BEDA4CAB0" xlink:to="loc_lly_LossContingencyNumberOfCases_AECE5201440CC259F090325BEDA9C0BE" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LossContingencyDamagesAwardedValue" xlink:label="loc_us-gaap_LossContingencyDamagesAwardedValue_BB57EF122AB519777856325BEDA9D4A5" xlink:type="locator" />
    <definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_760E6EA6C9147196AFDE325BEDA4CAB0" xlink:to="loc_us-gaap_LossContingencyDamagesAwardedValue_BB57EF122AB519777856325BEDA9D4A5" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LitigationSettlementAmount" xlink:label="loc_us-gaap_LitigationSettlementAmount_67E395AE645577FC348E325BEDA9AB7E" xlink:type="locator" />
    <definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_760E6EA6C9147196AFDE325BEDA4CAB0" xlink:to="loc_us-gaap_LitigationSettlementAmount_67E395AE645577FC348E325BEDA9AB7E" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_LossContingencyPartiesJointlyandSeverallyLiableinLitigationActualOptInPercent" xlink:label="loc_lly_LossContingencyPartiesJointlyandSeverallyLiableinLitigationActualOptInPercent_36D81B16EED8A7F99493325BEDA9559D" xlink:type="locator" />
    <definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_760E6EA6C9147196AFDE325BEDA4CAB0" xlink:to="loc_lly_LossContingencyPartiesJointlyandSeverallyLiableinLitigationActualOptInPercent_36D81B16EED8A7F99493325BEDA9559D" xlink:type="arc" />
  </definitionLink>
  <definitionLink xlink:role="http://www.lilly.com/role/DocumentAndEntityInformation" xlink:type="extended">
    <loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_DocumentInformationLineItems" xlink:label="loc_dei_DocumentInformationLineItems_D44B0CB826C195BEF6E55E7478290778" xlink:type="locator" />
    <loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_DocumentInformationTable" xlink:label="loc_dei_DocumentInformationTable_DF6017F5F55950BCF09F5E74782909C2" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_dei_DocumentInformationLineItems_D44B0CB826C195BEF6E55E7478290778" xlink:to="loc_dei_DocumentInformationTable_DF6017F5F55950BCF09F5E74782909C2" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment" />
    <loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_DocumentInformationDocumentAxis" xlink:label="loc_dei_DocumentInformationDocumentAxis_B903F569F02AFA3D50E05E74782907C4" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_dei_DocumentInformationTable_DF6017F5F55950BCF09F5E74782909C2" xlink:to="loc_dei_DocumentInformationDocumentAxis_B903F569F02AFA3D50E05E74782907C4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_DocumentDomain" xlink:label="loc_dei_DocumentDomain_60D42022FE5EE63FEACA5E7478298753_default" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_dei_DocumentInformationDocumentAxis_B903F569F02AFA3D50E05E74782907C4" xlink:to="loc_dei_DocumentDomain_60D42022FE5EE63FEACA5E7478298753_default" xlink:type="arc" />
    <loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_DocumentDomain" xlink:label="loc_dei_DocumentDomain_60D42022FE5EE63FEACA5E7478298753" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_dei_DocumentInformationDocumentAxis_B903F569F02AFA3D50E05E74782907C4" xlink:to="loc_dei_DocumentDomain_60D42022FE5EE63FEACA5E7478298753" xlink:type="arc" />
    <loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_DocumentType" xlink:label="loc_dei_DocumentType_B86AD6536E6C4AE3A7A95E7478290420" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_D44B0CB826C195BEF6E55E7478290778" xlink:to="loc_dei_DocumentType_B86AD6536E6C4AE3A7A95E7478290420" xlink:type="arc" />
    <loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_AmendmentFlag" xlink:label="loc_dei_AmendmentFlag_90693F58A2B241EC97B15E747829C458" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_D44B0CB826C195BEF6E55E7478290778" xlink:to="loc_dei_AmendmentFlag_90693F58A2B241EC97B15E747829C458" xlink:type="arc" />
    <loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_DocumentPeriodEndDate" xlink:label="loc_dei_DocumentPeriodEndDate_912A002DEA00E6925BA25E747829BA87" xlink:type="locator" />
    <definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_D44B0CB826C195BEF6E55E7478290778" xlink:to="loc_dei_DocumentPeriodEndDate_912A002DEA00E6925BA25E747829BA87" xlink:type="arc" />
    <loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_DocumentFiscalYearFocus" xlink:label="loc_dei_DocumentFiscalYearFocus_A6E3508B5A8B4C061B8F5E7478291B77" xlink:type="locator" />
    <definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_D44B0CB826C195BEF6E55E7478290778" xlink:to="loc_dei_DocumentFiscalYearFocus_A6E3508B5A8B4C061B8F5E7478291B77" xlink:type="arc" />
    <loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_DocumentFiscalPeriodFocus" xlink:label="loc_dei_DocumentFiscalPeriodFocus_35AF911B0EDA889EF6A05E7478290898" xlink:type="locator" />
    <definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_D44B0CB826C195BEF6E55E7478290778" xlink:to="loc_dei_DocumentFiscalPeriodFocus_35AF911B0EDA889EF6A05E7478290898" xlink:type="arc" />
    <loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_EntityRegistrantName" xlink:label="loc_dei_EntityRegistrantName_DA1433C9B9B63191E1B35E747829CC14" xlink:type="locator" />
    <definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_D44B0CB826C195BEF6E55E7478290778" xlink:to="loc_dei_EntityRegistrantName_DA1433C9B9B63191E1B35E747829CC14" xlink:type="arc" />
    <loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_EntityCentralIndexKey" xlink:label="loc_dei_EntityCentralIndexKey_0AA069EDACC66C47DD805E747829B49D" xlink:type="locator" />
    <definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_D44B0CB826C195BEF6E55E7478290778" xlink:to="loc_dei_EntityCentralIndexKey_0AA069EDACC66C47DD805E747829B49D" xlink:type="arc" />
    <loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_CurrentFiscalYearEndDate" xlink:label="loc_dei_CurrentFiscalYearEndDate_509CABAFCD9BBD649F5B5E747829FD2C" xlink:type="locator" />
    <definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_D44B0CB826C195BEF6E55E7478290778" xlink:to="loc_dei_CurrentFiscalYearEndDate_509CABAFCD9BBD649F5B5E747829FD2C" xlink:type="arc" />
    <loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_EntityWellKnownSeasonedIssuer" xlink:label="loc_dei_EntityWellKnownSeasonedIssuer_95A485EE7136EBCEBDAF5E747829421C" xlink:type="locator" />
    <definitionArc order="9" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_D44B0CB826C195BEF6E55E7478290778" xlink:to="loc_dei_EntityWellKnownSeasonedIssuer_95A485EE7136EBCEBDAF5E747829421C" xlink:type="arc" />
    <loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_EntityVoluntaryFilers" xlink:label="loc_dei_EntityVoluntaryFilers_C4D82F7297C95A1FFDD35E7478298DC9" xlink:type="locator" />
    <definitionArc order="10" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_D44B0CB826C195BEF6E55E7478290778" xlink:to="loc_dei_EntityVoluntaryFilers_C4D82F7297C95A1FFDD35E7478298DC9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_EntityCurrentReportingStatus" xlink:label="loc_dei_EntityCurrentReportingStatus_39FFF3A76F6C2ACABE835E747829EF80" xlink:type="locator" />
    <definitionArc order="11" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_D44B0CB826C195BEF6E55E7478290778" xlink:to="loc_dei_EntityCurrentReportingStatus_39FFF3A76F6C2ACABE835E747829EF80" xlink:type="arc" />
    <loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_EntityFilerCategory" xlink:label="loc_dei_EntityFilerCategory_43C34C792AB66D7379E05E74782990E4" xlink:type="locator" />
    <definitionArc order="12" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_D44B0CB826C195BEF6E55E7478290778" xlink:to="loc_dei_EntityFilerCategory_43C34C792AB66D7379E05E74782990E4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_EntityCommonStockSharesOutstanding" xlink:label="loc_dei_EntityCommonStockSharesOutstanding_950E5887ACF8DBD27A0C5E747829FDF1" xlink:type="locator" />
    <definitionArc order="13" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_D44B0CB826C195BEF6E55E7478290778" xlink:to="loc_dei_EntityCommonStockSharesOutstanding_950E5887ACF8DBD27A0C5E747829FDF1" xlink:type="arc" />
  </definitionLink>
  <definitionLink xlink:role="http://www.lilly.com/role/FinancialInstruments" xlink:type="extended" />
  <definitionLink xlink:role="http://www.lilly.com/role/FinancialInstrumentsDetails" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_0B3CB4CD9D239E3D1F12325BEE617D44" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FairValueByBalanceSheetGroupingTable" xlink:label="loc_us-gaap_FairValueByBalanceSheetGroupingTable_0FE84D4626F6CCE24E0D325BEE52D19B" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_0B3CB4CD9D239E3D1F12325BEE617D44" xlink:to="loc_us-gaap_FairValueByBalanceSheetGroupingTable_0FE84D4626F6CCE24E0D325BEE52D19B" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FairValueByMeasurementBasisAxis" xlink:label="loc_us-gaap_FairValueByMeasurementBasisAxis_9E0C6036180BE797932D325BEE53BA07" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueByBalanceSheetGroupingTable_0FE84D4626F6CCE24E0D325BEE52D19B" xlink:to="loc_us-gaap_FairValueByMeasurementBasisAxis_9E0C6036180BE797932D325BEE53BA07" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_PortionAtFairValueFairValueDisclosureMember" xlink:label="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_3F0D9BCE776B437D83FE325BEE53BFEB_default" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByMeasurementBasisAxis_9E0C6036180BE797932D325BEE53BA07" xlink:to="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_3F0D9BCE776B437D83FE325BEE53BFEB_default" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FairValueDisclosureItemAmountsDomain" xlink:label="loc_us-gaap_FairValueDisclosureItemAmountsDomain_8212D2C926FEA513E007325BEE53355D" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByMeasurementBasisAxis_9E0C6036180BE797932D325BEE53BA07" xlink:to="loc_us-gaap_FairValueDisclosureItemAmountsDomain_8212D2C926FEA513E007325BEE53355D" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_PortionAtFairValueFairValueDisclosureMember" xlink:label="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_3F0D9BCE776B437D83FE325BEE53BFEB" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueDisclosureItemAmountsDomain_8212D2C926FEA513E007325BEE53355D" xlink:to="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_3F0D9BCE776B437D83FE325BEE53BFEB" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_EstimateOfFairValueFairValueDisclosureMember" xlink:label="loc_us-gaap_EstimateOfFairValueFairValueDisclosureMember_2DFED7CAA754C84B2CB6325BEE53516F" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueDisclosureItemAmountsDomain_8212D2C926FEA513E007325BEE53355D" xlink:to="loc_us-gaap_EstimateOfFairValueFairValueDisclosureMember_2DFED7CAA754C84B2CB6325BEE53516F" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CarryingReportedAmountFairValueDisclosureMember" xlink:label="loc_us-gaap_CarryingReportedAmountFairValueDisclosureMember_CBF323BA0D39DBC31665325BEE539F44" xlink:type="locator" />
    <definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueDisclosureItemAmountsDomain_8212D2C926FEA513E007325BEE53355D" xlink:to="loc_us-gaap_CarryingReportedAmountFairValueDisclosureMember_CBF323BA0D39DBC31665325BEE539F44" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_PortionAtOtherThanFairValueFairValueDisclosureMember" xlink:label="loc_us-gaap_PortionAtOtherThanFairValueFairValueDisclosureMember_114EC89AC1D754E5A821325BEE53AC5A" xlink:type="locator" />
    <definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueDisclosureItemAmountsDomain_8212D2C926FEA513E007325BEE53355D" xlink:to="loc_us-gaap_PortionAtOtherThanFairValueFairValueDisclosureMember_114EC89AC1D754E5A821325BEE53AC5A" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DerivativeInstrumentRiskAxis" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_01EF3F29B37915FAC1BD325BEE534240" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueByBalanceSheetGroupingTable_0FE84D4626F6CCE24E0D325BEE52D19B" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_01EF3F29B37915FAC1BD325BEE534240" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DerivativeContractTypeDomain" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_0E60FC267EDD7B4F86D8325BEE53006F_default" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_01EF3F29B37915FAC1BD325BEE534240" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_0E60FC267EDD7B4F86D8325BEE53006F_default" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DerivativeContractTypeDomain" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_0E60FC267EDD7B4F86D8325BEE53006F" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_01EF3F29B37915FAC1BD325BEE534240" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_0E60FC267EDD7B4F86D8325BEE53006F" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CrossCurrencyInterestRateContractMember" xlink:label="loc_us-gaap_CrossCurrencyInterestRateContractMember_6D9E10D31F20234AA802325BEE53FA55" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_0E60FC267EDD7B4F86D8325BEE53006F" xlink:to="loc_us-gaap_CrossCurrencyInterestRateContractMember_6D9E10D31F20234AA802325BEE53FA55" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_ForeignCurrencyDenominatedDebtIssuanceMember" xlink:label="loc_lly_ForeignCurrencyDenominatedDebtIssuanceMember_909CCEFF4F544C77B35E325BEE53CA31" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_0E60FC267EDD7B4F86D8325BEE53006F" xlink:to="loc_lly_ForeignCurrencyDenominatedDebtIssuanceMember_909CCEFF4F544C77B35E325BEE53CA31" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_InterestRateSwapMember" xlink:label="loc_us-gaap_InterestRateSwapMember_767CC131DF3D7A2DF5F6325BEE53AF10" xlink:type="locator" />
    <definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_0E60FC267EDD7B4F86D8325BEE53006F" xlink:to="loc_us-gaap_InterestRateSwapMember_767CC131DF3D7A2DF5F6325BEE53AF10" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_BuyBritishPoundSellEuroMember" xlink:label="loc_lly_BuyBritishPoundSellEuroMember_A51DDBFFC40068623B84325BEE598648" xlink:type="locator" />
    <definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_0E60FC267EDD7B4F86D8325BEE53006F" xlink:to="loc_lly_BuyBritishPoundSellEuroMember_A51DDBFFC40068623B84325BEE598648" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_BuyUsDollarSellEuroMember" xlink:label="loc_lly_BuyUsDollarSellEuroMember_1753A0B141FBAAD348B7325BEE596037" xlink:type="locator" />
    <definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_0E60FC267EDD7B4F86D8325BEE53006F" xlink:to="loc_lly_BuyUsDollarSellEuroMember_1753A0B141FBAAD348B7325BEE596037" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_BuyEuroSellUsDollarMember" xlink:label="loc_lly_BuyEuroSellUsDollarMember_B6A9249B262A46919959325BEE5967EF" xlink:type="locator" />
    <definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_0E60FC267EDD7B4F86D8325BEE53006F" xlink:to="loc_lly_BuyEuroSellUsDollarMember_B6A9249B262A46919959325BEE5967EF" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_BuyUSdollarSellJapaneseYenMember" xlink:label="loc_lly_BuyUSdollarSellJapaneseYenMember_502DF3E0F2A37CF71F59325BEE592C1D" xlink:type="locator" />
    <definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_0E60FC267EDD7B4F86D8325BEE53006F" xlink:to="loc_lly_BuyUSdollarSellJapaneseYenMember_502DF3E0F2A37CF71F59325BEE592C1D" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_BuyeurosellBritishpoundMember" xlink:label="loc_lly_BuyeurosellBritishpoundMember_A3684D03F2AFCAE6514B325BEE596F81" xlink:type="locator" />
    <definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_0E60FC267EDD7B4F86D8325BEE53006F" xlink:to="loc_lly_BuyeurosellBritishpoundMember_A3684D03F2AFCAE6514B325BEE596F81" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_BuyUSdollarSellBritishpoundMember" xlink:label="loc_lly_BuyUSdollarSellBritishpoundMember_6F2F220F9801307024C3325BEE594FFF" xlink:type="locator" />
    <definitionArc order="9" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_0E60FC267EDD7B4F86D8325BEE53006F" xlink:to="loc_lly_BuyUSdollarSellBritishpoundMember_6F2F220F9801307024C3325BEE594FFF" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_BuySwissfrancsSellUSdollarMember" xlink:label="loc_lly_BuySwissfrancsSellUSdollarMember_227D2121B013778517F7325BEE59B3AC" xlink:type="locator" />
    <definitionArc order="10" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_0E60FC267EDD7B4F86D8325BEE53006F" xlink:to="loc_lly_BuySwissfrancsSellUSdollarMember_227D2121B013778517F7325BEE59B3AC" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_EquityContractMember" xlink:label="loc_us-gaap_EquityContractMember_A7DF349AF260DEB260DE325BEE597BFB" xlink:type="locator" />
    <definitionArc order="11" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_0E60FC267EDD7B4F86D8325BEE53006F" xlink:to="loc_us-gaap_EquityContractMember_A7DF349AF260DEB260DE325BEE597BFB" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_HedgedFixedRateDebtMember" xlink:label="loc_lly_HedgedFixedRateDebtMember_8A375E9D72DBD4195BCD325BEE59A93D" xlink:type="locator" />
    <definitionArc order="12" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_0E60FC267EDD7B4F86D8325BEE53006F" xlink:to="loc_lly_HedgedFixedRateDebtMember_8A375E9D72DBD4195BCD325BEE59A93D" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_InterestRateContractMember" xlink:label="loc_us-gaap_InterestRateContractMember_51823F8A3B47E0B1505A325BEE596A73" xlink:type="locator" />
    <definitionArc order="13" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_0E60FC267EDD7B4F86D8325BEE53006F" xlink:to="loc_us-gaap_InterestRateContractMember_51823F8A3B47E0B1505A325BEE596A73" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ForeignExchangeContractMember" xlink:label="loc_us-gaap_ForeignExchangeContractMember_B8D8FE5183001049AF10325BEE593B85" xlink:type="locator" />
    <definitionArc order="14" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_0E60FC267EDD7B4F86D8325BEE53006F" xlink:to="loc_us-gaap_ForeignExchangeContractMember_B8D8FE5183001049AF10325BEE593B85" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_MajorTypesOfDebtAndEquitySecuritiesAxis" xlink:label="loc_us-gaap_MajorTypesOfDebtAndEquitySecuritiesAxis_102BA07C8BE028D19187325BEE596399" xlink:type="locator" />
    <definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueByBalanceSheetGroupingTable_0FE84D4626F6CCE24E0D325BEE52D19B" xlink:to="loc_us-gaap_MajorTypesOfDebtAndEquitySecuritiesAxis_102BA07C8BE028D19187325BEE596399" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain" xlink:label="loc_us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain_3196607554B4800A07F5325BEE59CF15_default" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_MajorTypesOfDebtAndEquitySecuritiesAxis_102BA07C8BE028D19187325BEE596399" xlink:to="loc_us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain_3196607554B4800A07F5325BEE59CF15_default" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain" xlink:label="loc_us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain_3196607554B4800A07F5325BEE59CF15" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_MajorTypesOfDebtAndEquitySecuritiesAxis_102BA07C8BE028D19187325BEE596399" xlink:to="loc_us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain_3196607554B4800A07F5325BEE59CF15" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CorporateDebtSecuritiesMember" xlink:label="loc_us-gaap_CorporateDebtSecuritiesMember_2906A11A7094358A6BD6325BEE590FE6" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain_3196607554B4800A07F5325BEE59CF15" xlink:to="loc_us-gaap_CorporateDebtSecuritiesMember_2906A11A7094358A6BD6325BEE590FE6" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_USGovernmentAgenciesDebtSecuritiesMember" xlink:label="loc_us-gaap_USGovernmentAgenciesDebtSecuritiesMember_DA308BB4C2A97078B8A4325BEE590657" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain_3196607554B4800A07F5325BEE59CF15" xlink:to="loc_us-gaap_USGovernmentAgenciesDebtSecuritiesMember_DA308BB4C2A97078B8A4325BEE590657" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ForeignGovernmentDebtSecuritiesMember" xlink:label="loc_us-gaap_ForeignGovernmentDebtSecuritiesMember_36ED7C38131ADA9363B0325BEE5A6649" xlink:type="locator" />
    <definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain_3196607554B4800A07F5325BEE59CF15" xlink:to="loc_us-gaap_ForeignGovernmentDebtSecuritiesMember_36ED7C38131ADA9363B0325BEE5A6649" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_OtherDebtSecuritiesMember" xlink:label="loc_us-gaap_OtherDebtSecuritiesMember_C2CCA781379A6A6DF5D4325BEE5AA405" xlink:type="locator" />
    <definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain_3196607554B4800A07F5325BEE59CF15" xlink:to="loc_us-gaap_OtherDebtSecuritiesMember_C2CCA781379A6A6DF5D4325BEE5AA405" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_MortgageBackedSecuritiesMember" xlink:label="loc_us-gaap_MortgageBackedSecuritiesMember_A50DC14EECBC6ADA140D325BEE5A9DAC" xlink:type="locator" />
    <definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain_3196607554B4800A07F5325BEE59CF15" xlink:to="loc_us-gaap_MortgageBackedSecuritiesMember_A50DC14EECBC6ADA140D325BEE5A9DAC" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AssetBackedSecuritiesMember" xlink:label="loc_us-gaap_AssetBackedSecuritiesMember_1C22904B6D3071F949DB325BEE5AD4DB" xlink:type="locator" />
    <definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain_3196607554B4800A07F5325BEE59CF15" xlink:to="loc_us-gaap_AssetBackedSecuritiesMember_1C22904B6D3071F949DB325BEE5AD4DB" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_EquitySecuritiesMember" xlink:label="loc_us-gaap_EquitySecuritiesMember_4153A7810AB9E7849CE5325BEE5A8A59" xlink:type="locator" />
    <definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain_3196607554B4800A07F5325BEE59CF15" xlink:to="loc_us-gaap_EquitySecuritiesMember_4153A7810AB9E7849CE5325BEE5A8A59" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_EquityMethodAndOtherInvestmentsMember" xlink:label="loc_lly_EquityMethodAndOtherInvestmentsMember_3C2D1EC739E06037BCAA325BEE5AF77B" xlink:type="locator" />
    <definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain_3196607554B4800A07F5325BEE59CF15" xlink:to="loc_lly_EquityMethodAndOtherInvestmentsMember_3C2D1EC739E06037BCAA325BEE5AF77B" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_E555079FB7934DED47E2325BEE5AD796" xlink:type="locator" />
    <definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueByBalanceSheetGroupingTable_0FE84D4626F6CCE24E0D325BEE52D19B" xlink:to="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_E555079FB7934DED47E2325BEE5AD796" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_2337549D1BABCB1633EF325BEE5AD931_default" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_E555079FB7934DED47E2325BEE5AD796" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_2337549D1BABCB1633EF325BEE5AD931_default" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_2337549D1BABCB1633EF325BEE5AD931" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_E555079FB7934DED47E2325BEE5AD796" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_2337549D1BABCB1633EF325BEE5AD931" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FairValueInputsLevel1Member" xlink:label="loc_us-gaap_FairValueInputsLevel1Member_09BC944173571F69D42D325BEE5A3BE3" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_2337549D1BABCB1633EF325BEE5AD931" xlink:to="loc_us-gaap_FairValueInputsLevel1Member_09BC944173571F69D42D325BEE5A3BE3" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FairValueInputsLevel2Member" xlink:label="loc_us-gaap_FairValueInputsLevel2Member_BE4C93CCCCC475CD5827325BEE5A3F74" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_2337549D1BABCB1633EF325BEE5AD931" xlink:to="loc_us-gaap_FairValueInputsLevel2Member_BE4C93CCCCC475CD5827325BEE5A3F74" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FairValueInputsLevel3Member" xlink:label="loc_us-gaap_FairValueInputsLevel3Member_3FA1460FB824738B4263325BEE5A2C29" xlink:type="locator" />
    <definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_2337549D1BABCB1633EF325BEE5AD931" xlink:to="loc_us-gaap_FairValueInputsLevel3Member_3FA1460FB824738B4263325BEE5A2C29" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_HedgingDesignationAxis" xlink:label="loc_us-gaap_HedgingDesignationAxis_BBAB9E9ECE593DC8A81C325BEE5ADF03" xlink:type="locator" />
    <definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueByBalanceSheetGroupingTable_0FE84D4626F6CCE24E0D325BEE52D19B" xlink:to="loc_us-gaap_HedgingDesignationAxis_BBAB9E9ECE593DC8A81C325BEE5ADF03" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_HedgingDesignationDomain" xlink:label="loc_us-gaap_HedgingDesignationDomain_CDA6534AA3D3E4B2010C325BEE5A5071_default" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_HedgingDesignationAxis_BBAB9E9ECE593DC8A81C325BEE5ADF03" xlink:to="loc_us-gaap_HedgingDesignationDomain_CDA6534AA3D3E4B2010C325BEE5A5071_default" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_HedgingDesignationDomain" xlink:label="loc_us-gaap_HedgingDesignationDomain_CDA6534AA3D3E4B2010C325BEE5A5071" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_HedgingDesignationAxis_BBAB9E9ECE593DC8A81C325BEE5ADF03" xlink:to="loc_us-gaap_HedgingDesignationDomain_CDA6534AA3D3E4B2010C325BEE5A5071" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DesignatedAsHedgingInstrumentMember" xlink:label="loc_us-gaap_DesignatedAsHedgingInstrumentMember_F72789F3303A5CF9A378325BEE5AA9C6" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingDesignationDomain_CDA6534AA3D3E4B2010C325BEE5A5071" xlink:to="loc_us-gaap_DesignatedAsHedgingInstrumentMember_F72789F3303A5CF9A378325BEE5AA9C6" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_NondesignatedMember" xlink:label="loc_us-gaap_NondesignatedMember_B7195E9E3D5C5E0EE7A7325BEE5A93B7" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingDesignationDomain_CDA6534AA3D3E4B2010C325BEE5A5071" xlink:to="loc_us-gaap_NondesignatedMember_B7195E9E3D5C5E0EE7A7325BEE5A93B7" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_BalanceSheetLocationAxis" xlink:label="loc_us-gaap_BalanceSheetLocationAxis_70F2ADA73F732AF11EE3325BEE5ADB74" xlink:type="locator" />
    <definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueByBalanceSheetGroupingTable_0FE84D4626F6CCE24E0D325BEE52D19B" xlink:to="loc_us-gaap_BalanceSheetLocationAxis_70F2ADA73F732AF11EE3325BEE5ADB74" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_BalanceSheetLocationDomain" xlink:label="loc_us-gaap_BalanceSheetLocationDomain_6474EEDB763377202F23325BEE5A9A7D_default" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BalanceSheetLocationAxis_70F2ADA73F732AF11EE3325BEE5ADB74" xlink:to="loc_us-gaap_BalanceSheetLocationDomain_6474EEDB763377202F23325BEE5A9A7D_default" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_BalanceSheetLocationDomain" xlink:label="loc_us-gaap_BalanceSheetLocationDomain_6474EEDB763377202F23325BEE5A9A7D" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BalanceSheetLocationAxis_70F2ADA73F732AF11EE3325BEE5ADB74" xlink:to="loc_us-gaap_BalanceSheetLocationDomain_6474EEDB763377202F23325BEE5A9A7D" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_OtherAssetsMember" xlink:label="loc_us-gaap_OtherAssetsMember_BAF09712F31713C431A3325BEE5A9C66" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BalanceSheetLocationDomain_6474EEDB763377202F23325BEE5A9A7D" xlink:to="loc_us-gaap_OtherAssetsMember_BAF09712F31713C431A3325BEE5A9C66" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DebtInstrumentRedemptionPeriodAxis" xlink:label="loc_us-gaap_DebtInstrumentRedemptionPeriodAxis_CED721BBE518BF9A4EDB325BEE6071FB" xlink:type="locator" />
    <definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueByBalanceSheetGroupingTable_0FE84D4626F6CCE24E0D325BEE52D19B" xlink:to="loc_us-gaap_DebtInstrumentRedemptionPeriodAxis_CED721BBE518BF9A4EDB325BEE6071FB" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DebtInstrumentRedemptionPeriodDomain" xlink:label="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_B873EDE070D3CB91A787325BEE6073AD_default" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentRedemptionPeriodAxis_CED721BBE518BF9A4EDB325BEE6071FB" xlink:to="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_B873EDE070D3CB91A787325BEE6073AD_default" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DebtInstrumentRedemptionPeriodDomain" xlink:label="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_B873EDE070D3CB91A787325BEE6073AD" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentRedemptionPeriodAxis_CED721BBE518BF9A4EDB325BEE6071FB" xlink:to="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_B873EDE070D3CB91A787325BEE6073AD" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_MaturityDate2019Member" xlink:label="loc_lly_MaturityDate2019Member_5DD93EE82ACDA54C9103325BEE60E3B0" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_B873EDE070D3CB91A787325BEE6073AD" xlink:to="loc_lly_MaturityDate2019Member_5DD93EE82ACDA54C9103325BEE60E3B0" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_MaturityDate2018Member" xlink:label="loc_lly_MaturityDate2018Member_98A9C00DC1227B614596325BEE6095FC" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_B873EDE070D3CB91A787325BEE6073AD" xlink:to="loc_lly_MaturityDate2018Member_98A9C00DC1227B614596325BEE6095FC" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_MaturityDate2024Member" xlink:label="loc_lly_MaturityDate2024Member_35D02550C6ADC70FBF86325BEE601E17" xlink:type="locator" />
    <definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_B873EDE070D3CB91A787325BEE6073AD" xlink:to="loc_lly_MaturityDate2024Member_35D02550C6ADC70FBF86325BEE601E17" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_MaturityDate2028Member" xlink:label="loc_lly_MaturityDate2028Member_85A8A88F487010799C45325BEE61103D" xlink:type="locator" />
    <definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_B873EDE070D3CB91A787325BEE6073AD" xlink:to="loc_lly_MaturityDate2028Member_85A8A88F487010799C45325BEE61103D" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_MaturityDate2025Member" xlink:label="loc_lly_MaturityDate2025Member_316363888679937D88C3325BEE615DBD" xlink:type="locator" />
    <definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_B873EDE070D3CB91A787325BEE6073AD" xlink:to="loc_lly_MaturityDate2025Member_316363888679937D88C3325BEE615DBD" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_MaturityDate2045Member" xlink:label="loc_lly_MaturityDate2045Member_16FF1DF3524B8E1F20DF325BEE61DC2A" xlink:type="locator" />
    <definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_B873EDE070D3CB91A787325BEE6073AD" xlink:to="loc_lly_MaturityDate2045Member_16FF1DF3524B8E1F20DF325BEE61DC2A" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_MaturityDate2022MemberMember" xlink:label="loc_lly_MaturityDate2022MemberMember_B9A23DA6D224C4A4B870325BEE61EE9B" xlink:type="locator" />
    <definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_B873EDE070D3CB91A787325BEE6073AD" xlink:to="loc_lly_MaturityDate2022MemberMember_B9A23DA6D224C4A4B870325BEE61EE9B" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_MaturityDate2026Member" xlink:label="loc_lly_MaturityDate2026Member_C4867343D3818B8E7D6A325BEE61AB5E" xlink:type="locator" />
    <definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_B873EDE070D3CB91A787325BEE6073AD" xlink:to="loc_lly_MaturityDate2026Member_C4867343D3818B8E7D6A325BEE61AB5E" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_MaturityDate2030Member" xlink:label="loc_lly_MaturityDate2030Member_31E3AA6F4FE215F9589E325BEE61779D" xlink:type="locator" />
    <definitionArc order="9" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_B873EDE070D3CB91A787325BEE6073AD" xlink:to="loc_lly_MaturityDate2030Member_31E3AA6F4FE215F9589E325BEE61779D" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_EuroDenominatedDebtIssuanceMember" xlink:label="loc_lly_EuroDenominatedDebtIssuanceMember_E9D339F1838B4D1207E3325BEE6110B5" xlink:type="locator" />
    <definitionArc order="10" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_B873EDE070D3CB91A787325BEE6073AD" xlink:to="loc_lly_EuroDenominatedDebtIssuanceMember_E9D339F1838B4D1207E3325BEE6110B5" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_SwissFrancDenominatedDebtIssuanceMember" xlink:label="loc_lly_SwissFrancDenominatedDebtIssuanceMember_876D332381C96F0A214E325BEE61E77E" xlink:type="locator" />
    <definitionArc order="11" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_B873EDE070D3CB91A787325BEE6073AD" xlink:to="loc_lly_SwissFrancDenominatedDebtIssuanceMember_876D332381C96F0A214E325BEE61E77E" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_TransferOfFinancialAssetsAccountedForAsSalesAmountDerecognized" xlink:label="loc_us-gaap_TransferOfFinancialAssetsAccountedForAsSalesAmountDerecognized_A7E3F842CB7861C25A94325BEE6147DB" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_0B3CB4CD9D239E3D1F12325BEE617D44" xlink:to="loc_us-gaap_TransferOfFinancialAssetsAccountedForAsSalesAmountDerecognized_A7E3F842CB7861C25A94325BEE6147DB" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_InterestExpense" xlink:label="loc_us-gaap_InterestExpense_8A8114925D1C8E81E25D325BEE617E7C" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_0B3CB4CD9D239E3D1F12325BEE617D44" xlink:to="loc_us-gaap_InterestExpense_8A8114925D1C8E81E25D325BEE617E7C" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AvailableForSaleSecuritiesAccumulatedGrossUnrealizedGainBeforeTax" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_1AD6AC8D6B4357B20DEF325BEE617ABC" xlink:type="locator" />
    <definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_0B3CB4CD9D239E3D1F12325BEE617D44" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_1AD6AC8D6B4357B20DEF325BEE617ABC" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AvailableForSaleSecuritiesAccumulatedGrossUnrealizedLossBeforeTax" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_9BA354791C4938EFF85B325BEE61E108" xlink:type="locator" />
    <definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_0B3CB4CD9D239E3D1F12325BEE617D44" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_9BA354791C4938EFF85B325BEE61E108" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AvailableForSaleSecuritiesGrossRealizedGains" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesGrossRealizedGains_D7283CF192848F58B67D325BEE61C5C3" xlink:type="locator" />
    <definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_0B3CB4CD9D239E3D1F12325BEE617D44" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesGrossRealizedGains_D7283CF192848F58B67D325BEE61C5C3" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity" xlink:label="loc_us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity_AA8C343E7EFF566DA563325BEE61B5CB" xlink:type="locator" />
    <definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_0B3CB4CD9D239E3D1F12325BEE617D44" xlink:to="loc_us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity_AA8C343E7EFF566DA563325BEE61B5CB" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LineOfCreditFacilityRemainingBorrowingCapacity" xlink:label="loc_us-gaap_LineOfCreditFacilityRemainingBorrowingCapacity_CB4E9F1771FF221AC20A325BEE612ED9" xlink:type="locator" />
    <definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_0B3CB4CD9D239E3D1F12325BEE617D44" xlink:to="loc_us-gaap_LineOfCreditFacilityRemainingBorrowingCapacity_CB4E9F1771FF221AC20A325BEE612ED9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ShortTermBorrowings" xlink:label="loc_us-gaap_ShortTermBorrowings_A299B98D7EC992A7A180325BEE62F0C5" xlink:type="locator" />
    <definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_0B3CB4CD9D239E3D1F12325BEE617D44" xlink:to="loc_us-gaap_ShortTermBorrowings_A299B98D7EC992A7A180325BEE62F0C5" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_RepaymentsOfLongTermDebt" xlink:label="loc_us-gaap_RepaymentsOfLongTermDebt_AA4F65D76B350DDC9F90325BEE62054F" xlink:type="locator" />
    <definitionArc order="9" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_0B3CB4CD9D239E3D1F12325BEE617D44" xlink:to="loc_us-gaap_RepaymentsOfLongTermDebt_AA4F65D76B350DDC9F90325BEE62054F" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_C881499633CD3DA31047325BEE62A47A" xlink:type="locator" />
    <definitionArc order="10" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_0B3CB4CD9D239E3D1F12325BEE617D44" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_C881499633CD3DA31047325BEE62A47A" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LiabilitiesFairValueDisclosureNonrecurring" xlink:label="loc_us-gaap_LiabilitiesFairValueDisclosureNonrecurring_6B43A4008C24BB6B7090325BEE624AAF" xlink:type="locator" />
    <definitionArc order="11" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_0B3CB4CD9D239E3D1F12325BEE617D44" xlink:to="loc_us-gaap_LiabilitiesFairValueDisclosureNonrecurring_6B43A4008C24BB6B7090325BEE624AAF" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ChangeInUnrealizedGainLossOnHedgedItemInFairValueHedge1" xlink:label="loc_us-gaap_ChangeInUnrealizedGainLossOnHedgedItemInFairValueHedge1_D63960DE164BC474FCCB325BEE627AB3" xlink:type="locator" />
    <definitionArc order="12" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_0B3CB4CD9D239E3D1F12325BEE617D44" xlink:to="loc_us-gaap_ChangeInUnrealizedGainLossOnHedgedItemInFairValueHedge1_D63960DE164BC474FCCB325BEE627AB3" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CashAndCashEquivalentsFairValueDisclosure" xlink:label="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_C175835E288D80479048325BEE626661" xlink:type="locator" />
    <definitionArc order="13" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_0B3CB4CD9D239E3D1F12325BEE617D44" xlink:to="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_C175835E288D80479048325BEE626661" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LongTermDebt" xlink:label="loc_us-gaap_LongTermDebt_826EC91A5313EF416E40325BEE62F89C" xlink:type="locator" />
    <definitionArc order="14" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_0B3CB4CD9D239E3D1F12325BEE617D44" xlink:to="loc_us-gaap_LongTermDebt_826EC91A5313EF416E40325BEE62F89C" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DebtInstrumentInterestRateStatedPercentage" xlink:label="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_457842BE12C21E1F6F67325BEE620683" xlink:type="locator" />
    <definitionArc order="15" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_0B3CB4CD9D239E3D1F12325BEE617D44" xlink:to="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_457842BE12C21E1F6F67325BEE620683" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ProceedsFromIssuanceOfLongTermDebt" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfLongTermDebt_CAFA8265B2EC0A2E99C8325BEE62FBDE" xlink:type="locator" />
    <definitionArc order="16" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_0B3CB4CD9D239E3D1F12325BEE617D44" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfLongTermDebt_CAFA8265B2EC0A2E99C8325BEE62FBDE" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ExtinguishmentOfDebtAmount" xlink:label="loc_us-gaap_ExtinguishmentOfDebtAmount_59B64086AE7477E70028325BEE622CEF" xlink:type="locator" />
    <definitionArc order="17" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_0B3CB4CD9D239E3D1F12325BEE617D44" xlink:to="loc_us-gaap_ExtinguishmentOfDebtAmount_59B64086AE7477E70028325BEE622CEF" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_GainsLossesOnExtinguishmentOfDebt" xlink:label="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_D57CBF6C9CEF76CD4599325BEE62294F" xlink:type="locator" />
    <definitionArc order="18" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_0B3CB4CD9D239E3D1F12325BEE617D44" xlink:to="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_D57CBF6C9CEF76CD4599325BEE62294F" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DerivativeAssetsCurrent" xlink:label="loc_us-gaap_DerivativeAssetsCurrent_1DE2A325B2ACB4C64242325BEE6293D8" xlink:type="locator" />
    <definitionArc order="19" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_0B3CB4CD9D239E3D1F12325BEE617D44" xlink:to="loc_us-gaap_DerivativeAssetsCurrent_1DE2A325B2ACB4C64242325BEE6293D8" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AvailableforsaleSecuritiesInUnrealizedLossPositionsQualitativeDisclosureOtherPercentageOfNonperformingAssets" xlink:label="loc_us-gaap_AvailableforsaleSecuritiesInUnrealizedLossPositionsQualitativeDisclosureOtherPercentageOfNonperformingAssets_3DD1B4A7D6E3E8808446325BEE670754" xlink:type="locator" />
    <definitionArc order="20" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_0B3CB4CD9D239E3D1F12325BEE617D44" xlink:to="loc_us-gaap_AvailableforsaleSecuritiesInUnrealizedLossPositionsQualitativeDisclosureOtherPercentageOfNonperformingAssets_3DD1B4A7D6E3E8808446325BEE670754" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_MaximumRemainingMaturityOfForeignCurrencyDerivatives1" xlink:label="loc_us-gaap_MaximumRemainingMaturityOfForeignCurrencyDerivatives1_29100B2D3C30D80233BC325BEE678B0C" xlink:type="locator" />
    <definitionArc order="21" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_0B3CB4CD9D239E3D1F12325BEE617D44" xlink:to="loc_us-gaap_MaximumRemainingMaturityOfForeignCurrencyDerivatives1_29100B2D3C30D80233BC325BEE678B0C" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LongTermDebtPercentageBearingFixedInterestRate" xlink:label="loc_us-gaap_LongTermDebtPercentageBearingFixedInterestRate_F6C120209ADB6F3B0DC9325BEE67C79D" xlink:type="locator" />
    <definitionArc order="22" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_0B3CB4CD9D239E3D1F12325BEE617D44" xlink:to="loc_us-gaap_LongTermDebtPercentageBearingFixedInterestRate_F6C120209ADB6F3B0DC9325BEE67C79D" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_DescriptionOfDerivativeActivityVolumePercent" xlink:label="loc_lly_DescriptionOfDerivativeActivityVolumePercent_F0C752A45382D531FA86325BEE6839B9" xlink:type="locator" />
    <definitionArc order="23" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_0B3CB4CD9D239E3D1F12325BEE617D44" xlink:to="loc_lly_DescriptionOfDerivativeActivityVolumePercent_F0C752A45382D531FA86325BEE6839B9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ChangeInUnrealizedGainLossOnFairValueHedgingInstruments1" xlink:label="loc_us-gaap_ChangeInUnrealizedGainLossOnFairValueHedgingInstruments1_1836408424BA519DF365325BEE6892DA" xlink:type="locator" />
    <definitionArc order="24" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_0B3CB4CD9D239E3D1F12325BEE617D44" xlink:to="loc_us-gaap_ChangeInUnrealizedGainLossOnFairValueHedgingInstruments1_1836408424BA519DF365325BEE6892DA" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_InterestRateCashFlowHedgeGainLossToBeReclassifiedDuringNext12MonthsNet" xlink:label="loc_us-gaap_InterestRateCashFlowHedgeGainLossToBeReclassifiedDuringNext12MonthsNet_E3A971A5DF32A816029C325BEE688C52" xlink:type="locator" />
    <definitionArc order="25" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_0B3CB4CD9D239E3D1F12325BEE617D44" xlink:to="loc_us-gaap_InterestRateCashFlowHedgeGainLossToBeReclassifiedDuringNext12MonthsNet_E3A971A5DF32A816029C325BEE688C52" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DerivativeInstrumentsLossReclassifiedFromAccumulatedOCIIntoIncomeEffectivePortion" xlink:label="loc_us-gaap_DerivativeInstrumentsLossReclassifiedFromAccumulatedOCIIntoIncomeEffectivePortion_58A113CD944BABE3BF61325BEE685D59" xlink:type="locator" />
    <definitionArc order="26" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_0B3CB4CD9D239E3D1F12325BEE617D44" xlink:to="loc_us-gaap_DerivativeInstrumentsLossReclassifiedFromAccumulatedOCIIntoIncomeEffectivePortion_58A113CD944BABE3BF61325BEE685D59" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_GainLossOnForeignCurrencyDerivativeInstrumentsNotDesignatedAsHedgingInstruments" xlink:label="loc_us-gaap_GainLossOnForeignCurrencyDerivativeInstrumentsNotDesignatedAsHedgingInstruments_EB88EE50B12D8F7D22EF325BEE68E570" xlink:type="locator" />
    <definitionArc order="27" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_0B3CB4CD9D239E3D1F12325BEE617D44" xlink:to="loc_us-gaap_GainLossOnForeignCurrencyDerivativeInstrumentsNotDesignatedAsHedgingInstruments_EB88EE50B12D8F7D22EF325BEE68E570" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DerivativeInstrumentsGainLossRecognizedInOtherComprehensiveIncomeEffectivePortionNet" xlink:label="loc_us-gaap_DerivativeInstrumentsGainLossRecognizedInOtherComprehensiveIncomeEffectivePortionNet_1CA4AC18780E07050E4E325BEE688C6F" xlink:type="locator" />
    <definitionArc order="28" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_0B3CB4CD9D239E3D1F12325BEE617D44" xlink:to="loc_us-gaap_DerivativeInstrumentsGainLossRecognizedInOtherComprehensiveIncomeEffectivePortionNet_1CA4AC18780E07050E4E325BEE688C6F" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DerivativeAssetsNoncurrent" xlink:label="loc_us-gaap_DerivativeAssetsNoncurrent_F4D003BE487BBB9DBD2A325BEE68E452" xlink:type="locator" />
    <definitionArc order="29" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_0B3CB4CD9D239E3D1F12325BEE617D44" xlink:to="loc_us-gaap_DerivativeAssetsNoncurrent_F4D003BE487BBB9DBD2A325BEE68E452" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DerivativeLiabilitiesCurrent" xlink:label="loc_us-gaap_DerivativeLiabilitiesCurrent_23A66E6AB22409D70788325BEE685ED0" xlink:type="locator" />
    <definitionArc order="30" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_0B3CB4CD9D239E3D1F12325BEE617D44" xlink:to="loc_us-gaap_DerivativeLiabilitiesCurrent_23A66E6AB22409D70788325BEE685ED0" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_BusinessCombinationContingentConsiderationLiabilityCurrent" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationLiabilityCurrent_97676AE11F937F26BF95325BEE68F493" xlink:type="locator" />
    <definitionArc order="31" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_0B3CB4CD9D239E3D1F12325BEE617D44" xlink:to="loc_us-gaap_BusinessCombinationContingentConsiderationLiabilityCurrent_97676AE11F937F26BF95325BEE68F493" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_BusinessCombinationContingentConsiderationLiabilityNoncurrent" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationLiabilityNoncurrent_ABC10771ABD7CEC6C3DE325BEE687689" xlink:type="locator" />
    <definitionArc order="32" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_0B3CB4CD9D239E3D1F12325BEE617D44" xlink:to="loc_us-gaap_BusinessCombinationContingentConsiderationLiabilityNoncurrent_ABC10771ABD7CEC6C3DE325BEE687689" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DerivativeLiabilitiesNoncurrent" xlink:label="loc_us-gaap_DerivativeLiabilitiesNoncurrent_F46CBA4712DB84A43662325BEE68F074" xlink:type="locator" />
    <definitionArc order="33" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_0B3CB4CD9D239E3D1F12325BEE617D44" xlink:to="loc_us-gaap_DerivativeLiabilitiesNoncurrent_F46CBA4712DB84A43662325BEE68F074" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1_3DEF34333359EA992AD7325BEE68E0D6" xlink:type="locator" />
    <definitionArc order="34" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_0B3CB4CD9D239E3D1F12325BEE617D44" xlink:to="loc_us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1_3DEF34333359EA992AD7325BEE68E0D6" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsFairValue" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsFairValue_AFAEB6FAB2FCF910FD6F325BEE68A1B8" xlink:type="locator" />
    <definitionArc order="35" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_0B3CB4CD9D239E3D1F12325BEE617D44" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsFairValue_AFAEB6FAB2FCF910FD6F325BEE68A1B8" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_AvailableForSaleSecuritiesContinuousUnrealizedGainPositionFairValue" xlink:label="loc_lly_AvailableForSaleSecuritiesContinuousUnrealizedGainPositionFairValue_B35A35E4070CE3686E30325BEE68F3C1" xlink:type="locator" />
    <definitionArc order="36" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_0B3CB4CD9D239E3D1F12325BEE617D44" xlink:to="loc_lly_AvailableForSaleSecuritiesContinuousUnrealizedGainPositionFairValue_B35A35E4070CE3686E30325BEE68F3C1" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionFairValue" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionFairValue_83C07BAB25055F4D0508325BEE687207" xlink:type="locator" />
    <definitionArc order="37" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_0B3CB4CD9D239E3D1F12325BEE617D44" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionFairValue_83C07BAB25055F4D0508325BEE687207" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ImpairmentOfInvestments" xlink:label="loc_us-gaap_ImpairmentOfInvestments_2037FC2811A51C783AD9325BEE681E72" xlink:type="locator" />
    <definitionArc order="38" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_0B3CB4CD9D239E3D1F12325BEE617D44" xlink:to="loc_us-gaap_ImpairmentOfInvestments_2037FC2811A51C783AD9325BEE681E72" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ProceedsFromSaleAndMaturityOfAvailableForSaleSecurities" xlink:label="loc_us-gaap_ProceedsFromSaleAndMaturityOfAvailableForSaleSecurities_27026AF91B88EC8D357D325BEE68BAF7" xlink:type="locator" />
    <definitionArc order="39" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_0B3CB4CD9D239E3D1F12325BEE617D44" xlink:to="loc_us-gaap_ProceedsFromSaleAndMaturityOfAvailableForSaleSecurities_27026AF91B88EC8D357D325BEE68BAF7" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AvailableForSaleSecuritiesGrossRealizedLosses" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesGrossRealizedLosses_EA412C3560EFBC6D2589325BEE697420" xlink:type="locator" />
    <definitionArc order="40" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_0B3CB4CD9D239E3D1F12325BEE617D44" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesGrossRealizedLosses_EA412C3560EFBC6D2589325BEE697420" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AvailableForSaleSecuritiesCurrentAbstract" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesCurrentAbstract_8080492C756577A34D51325BEE695621" xlink:type="locator" />
    <definitionArc order="41" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_0B3CB4CD9D239E3D1F12325BEE617D44" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesCurrentAbstract_8080492C756577A34D51325BEE695621" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent_7FE4073273F9E7865CCD325BEE69AA59" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesCurrentAbstract_8080492C756577A34D51325BEE695621" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent_7FE4073273F9E7865CCD325BEE69AA59" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AvailableForSaleSecuritiesEquitySecuritiesCurrent" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesEquitySecuritiesCurrent_DD130FC45235C46FC57D325BEE697F58" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesCurrentAbstract_8080492C756577A34D51325BEE695621" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesEquitySecuritiesCurrent_DD130FC45235C46FC57D325BEE697F58" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AvailableForSaleSecuritiesCurrent" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesCurrent_2F3B52264F77747BB745325BEE6940B8" xlink:type="locator" />
    <definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesCurrentAbstract_8080492C756577A34D51325BEE695621" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesCurrent_2F3B52264F77747BB745325BEE6940B8" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AvailableForSaleSecuritiesNoncurrentAbstract" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesNoncurrentAbstract_035AFFF45A5A8F0133DB325BEE694E5D" xlink:type="locator" />
    <definitionArc order="42" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_0B3CB4CD9D239E3D1F12325BEE617D44" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesNoncurrentAbstract_035AFFF45A5A8F0133DB325BEE694E5D" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecuritiesNoncurrent" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesNoncurrent_1F02970176CF0B0EA804325BEE695D8A" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesNoncurrentAbstract_035AFFF45A5A8F0133DB325BEE694E5D" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesNoncurrent_1F02970176CF0B0EA804325BEE695D8A" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AvailableForSaleSecuritiesEquitySecuritiesNoncurrent" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesEquitySecuritiesNoncurrent_B5612699BA37ACA5A553325BEE6962F5" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesNoncurrentAbstract_035AFFF45A5A8F0133DB325BEE694E5D" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesEquitySecuritiesNoncurrent_B5612699BA37ACA5A553325BEE6962F5" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_OtherLongTermInvestments" xlink:label="loc_us-gaap_OtherLongTermInvestments_131C35DDC6B758925221325BEE69DFAC" xlink:type="locator" />
    <definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesNoncurrentAbstract_035AFFF45A5A8F0133DB325BEE694E5D" xlink:to="loc_us-gaap_OtherLongTermInvestments_131C35DDC6B758925221325BEE69DFAC" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AvailableForSaleSecuritiesNoncurrent" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesNoncurrent_C10BE459B045ECAD1CD9325BEE6942A4" xlink:type="locator" />
    <definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesNoncurrentAbstract_035AFFF45A5A8F0133DB325BEE694E5D" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesNoncurrent_C10BE459B045ECAD1CD9325BEE6942A4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearFairValue" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearFairValue_063E838E02CD4DC9DD04325BEE690543" xlink:type="locator" />
    <definitionArc order="43" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_0B3CB4CD9D239E3D1F12325BEE617D44" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearFairValue_063E838E02CD4DC9DD04325BEE690543" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterFiveThroughTenYearsFairValue" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterFiveThroughTenYearsFairValue_B31B53044BAC884A9491325BEE694CDB" xlink:type="locator" />
    <definitionArc order="44" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_0B3CB4CD9D239E3D1F12325BEE617D44" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterFiveThroughTenYearsFairValue_B31B53044BAC884A9491325BEE694CDB" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterTenYearsFairValue" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterTenYearsFairValue_733097A1411FA2140D28325BEE697CCE" xlink:type="locator" />
    <definitionArc order="45" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_0B3CB4CD9D239E3D1F12325BEE617D44" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterTenYearsFairValue_733097A1411FA2140D28325BEE697CCE" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DerivativeLiabilityNotionalAmount" xlink:label="loc_us-gaap_DerivativeLiabilityNotionalAmount_241605463F23F09517AB325BEE696F94" xlink:type="locator" />
    <definitionArc order="46" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_0B3CB4CD9D239E3D1F12325BEE617D44" xlink:to="loc_us-gaap_DerivativeLiabilityNotionalAmount_241605463F23F09517AB325BEE696F94" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DerivativeAssetNotionalAmount" xlink:label="loc_us-gaap_DerivativeAssetNotionalAmount_063CC1DA664BF249E787325BEE69DAF8" xlink:type="locator" />
    <definitionArc order="47" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_0B3CB4CD9D239E3D1F12325BEE617D44" xlink:to="loc_us-gaap_DerivativeAssetNotionalAmount_063CC1DA664BF249E787325BEE69DAF8" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_PaymentsforProceedsfromHedgeOperatingActivities" xlink:label="loc_lly_PaymentsforProceedsfromHedgeOperatingActivities_3B01C60BFB186E51E2B7325BEE6E129D" xlink:type="locator" />
    <definitionArc order="48" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_0B3CB4CD9D239E3D1F12325BEE617D44" xlink:to="loc_lly_PaymentsforProceedsfromHedgeOperatingActivities_3B01C60BFB186E51E2B7325BEE6E129D" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_MaximumLengthOfTimeHedgedInInterestRateCashFlowHedge1" xlink:label="loc_us-gaap_MaximumLengthOfTimeHedgedInInterestRateCashFlowHedge1_726804754265A19179C0325BEE6F7F24" xlink:type="locator" />
    <definitionArc order="49" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_0B3CB4CD9D239E3D1F12325BEE617D44" xlink:to="loc_us-gaap_MaximumLengthOfTimeHedgedInInterestRateCashFlowHedge1_726804754265A19179C0325BEE6F7F24" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_GainLossOnInterestRateDerivativeInstrumentsNotDesignatedAsHedgingInstruments" xlink:label="loc_us-gaap_GainLossOnInterestRateDerivativeInstrumentsNotDesignatedAsHedgingInstruments_64E75F35D854C623A951325BEE6FED65" xlink:type="locator" />
    <definitionArc order="50" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_0B3CB4CD9D239E3D1F12325BEE617D44" xlink:to="loc_us-gaap_GainLossOnInterestRateDerivativeInstrumentsNotDesignatedAsHedgingInstruments_64E75F35D854C623A951325BEE6FED65" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_NotionalAmountOfNonderivativeInstruments" xlink:label="loc_us-gaap_NotionalAmountOfNonderivativeInstruments_C8727840457300638F96325BEE6FCB25" xlink:type="locator" />
    <definitionArc order="51" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_0B3CB4CD9D239E3D1F12325BEE617D44" xlink:to="loc_us-gaap_NotionalAmountOfNonderivativeInstruments_C8727840457300638F96325BEE6FCB25" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DerivativeRemainingMaturity1" xlink:label="loc_us-gaap_DerivativeRemainingMaturity1_776B4FC0B263400E0475325BEE6FB345" xlink:type="locator" />
    <definitionArc order="52" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_0B3CB4CD9D239E3D1F12325BEE617D44" xlink:to="loc_us-gaap_DerivativeRemainingMaturity1_776B4FC0B263400E0475325BEE6FB345" xlink:type="arc" />
    <loc xlink:href="http://xbrl.sec.gov/invest/2013/invest-2013-01-31.xsd#invest_DerivativeNotionalAmount" xlink:label="loc_invest_DerivativeNotionalAmount_55730A48261F6A1175FF325BEE6F9791" xlink:type="locator" />
    <definitionArc order="53" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_0B3CB4CD9D239E3D1F12325BEE617D44" xlink:to="loc_invest_DerivativeNotionalAmount_55730A48261F6A1175FF325BEE6F9791" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_InvestmentIncomeInterest" xlink:label="loc_us-gaap_InvestmentIncomeInterest_D8C414B53B33B08989D1325BEE6FFFD7" xlink:type="locator" />
    <definitionArc order="54" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_0B3CB4CD9D239E3D1F12325BEE617D44" xlink:to="loc_us-gaap_InvestmentIncomeInterest_D8C414B53B33B08989D1325BEE6FFFD7" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ForeignCurrencyTransactionGainLossRealized" xlink:label="loc_us-gaap_ForeignCurrencyTransactionGainLossRealized_D5909453E52E1D76152B325BEE6FADDF" xlink:type="locator" />
    <definitionArc order="55" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_0B3CB4CD9D239E3D1F12325BEE617D44" xlink:to="loc_us-gaap_ForeignCurrencyTransactionGainLossRealized_D5909453E52E1D76152B325BEE6FADDF" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_OtherNonoperatingIncomeExpense" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_CBCF17645DBADC633EEB325BEE700DE7" xlink:type="locator" />
    <definitionArc order="56" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_0B3CB4CD9D239E3D1F12325BEE617D44" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpense_CBCF17645DBADC633EEB325BEE700DE7" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_NonoperatingIncomeExpense" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_66686896474922CF88D7325BEE703380" xlink:type="locator" />
    <definitionArc order="57" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_0B3CB4CD9D239E3D1F12325BEE617D44" xlink:to="loc_us-gaap_NonoperatingIncomeExpense_66686896474922CF88D7325BEE703380" xlink:type="arc" />
  </definitionLink>
  <definitionLink xlink:role="http://www.lilly.com/role/FinancialInstrumentsPolicies" xlink:type="extended" />
  <definitionLink xlink:role="http://www.lilly.com/role/FinancialInstrumentsTables" xlink:type="extended" />
  <definitionLink xlink:role="http://www.lilly.com/role/ImplementationOfNewFinancialAccountingPronouncements" xlink:type="extended" />
  <definitionLink xlink:role="http://www.lilly.com/role/ImplementationOfNewFinancialAccountingPronouncementsImplementationOfNewAccountingPronouncementsTables" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems" xlink:label="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_C141BC3260D1F7E01920A5DAF5CD36F3" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleTable" xlink:label="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleTable_78B8C8AE4165AB49D5F2A5DAF5CD7F2B" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_C141BC3260D1F7E01920A5DAF5CD36F3" xlink:to="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleTable_78B8C8AE4165AB49D5F2A5DAF5CD7F2B" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AdjustmentsForNewAccountingPronouncementsAxis" xlink:label="loc_us-gaap_AdjustmentsForNewAccountingPronouncementsAxis_3C172C6C197CF98C5585A5DAF5CD5A4C" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleTable_78B8C8AE4165AB49D5F2A5DAF5CD7F2B" xlink:to="loc_us-gaap_AdjustmentsForNewAccountingPronouncementsAxis_3C172C6C197CF98C5585A5DAF5CD5A4C" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_TypeOfAdoptionMember" xlink:label="loc_us-gaap_TypeOfAdoptionMember_3932321A1E055237A914A5DAF5CDABE9_default" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AdjustmentsForNewAccountingPronouncementsAxis_3C172C6C197CF98C5585A5DAF5CD5A4C" xlink:to="loc_us-gaap_TypeOfAdoptionMember_3932321A1E055237A914A5DAF5CDABE9_default" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_TypeOfAdoptionMember" xlink:label="loc_us-gaap_TypeOfAdoptionMember_3932321A1E055237A914A5DAF5CDABE9" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AdjustmentsForNewAccountingPronouncementsAxis_3C172C6C197CF98C5585A5DAF5CD5A4C" xlink:to="loc_us-gaap_TypeOfAdoptionMember_3932321A1E055237A914A5DAF5CDABE9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AdjustmentsForChangeInAccountingPrincipleAxis" xlink:label="loc_us-gaap_AdjustmentsForChangeInAccountingPrincipleAxis_EDC0E1ECA5C18D358BDBA5DAF5CDAE26" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleTable_78B8C8AE4165AB49D5F2A5DAF5CD7F2B" xlink:to="loc_us-gaap_AdjustmentsForChangeInAccountingPrincipleAxis_EDC0E1ECA5C18D358BDBA5DAF5CDAE26" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ChangeInAccountingPrincipleMember" xlink:label="loc_us-gaap_ChangeInAccountingPrincipleMember_2B9EF8C076AB11E3E426A5DAF5CD3B27_default" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AdjustmentsForChangeInAccountingPrincipleAxis_EDC0E1ECA5C18D358BDBA5DAF5CDAE26" xlink:to="loc_us-gaap_ChangeInAccountingPrincipleMember_2B9EF8C076AB11E3E426A5DAF5CD3B27_default" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ChangeInAccountingPrincipleMember" xlink:label="loc_us-gaap_ChangeInAccountingPrincipleMember_2B9EF8C076AB11E3E426A5DAF5CD3B27" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AdjustmentsForChangeInAccountingPrincipleAxis_EDC0E1ECA5C18D358BDBA5DAF5CDAE26" xlink:to="loc_us-gaap_ChangeInAccountingPrincipleMember_2B9EF8C076AB11E3E426A5DAF5CD3B27" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_StatementScenarioAxis" xlink:label="loc_us-gaap_StatementScenarioAxis_D48EE6D72C878F98DDBEA5DAF5CDD39B" xlink:type="locator" />
    <definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleTable_78B8C8AE4165AB49D5F2A5DAF5CD7F2B" xlink:to="loc_us-gaap_StatementScenarioAxis_D48EE6D72C878F98DDBEA5DAF5CDD39B" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ScenarioUnspecifiedDomain" xlink:label="loc_us-gaap_ScenarioUnspecifiedDomain_6ED97390B7843DC28019A5DAF5CD701A_default" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementScenarioAxis_D48EE6D72C878F98DDBEA5DAF5CDD39B" xlink:to="loc_us-gaap_ScenarioUnspecifiedDomain_6ED97390B7843DC28019A5DAF5CD701A_default" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ScenarioUnspecifiedDomain" xlink:label="loc_us-gaap_ScenarioUnspecifiedDomain_6ED97390B7843DC28019A5DAF5CD701A" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementScenarioAxis_D48EE6D72C878F98DDBEA5DAF5CDD39B" xlink:to="loc_us-gaap_ScenarioUnspecifiedDomain_6ED97390B7843DC28019A5DAF5CD701A" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ScheduleOfNewAccountingPronouncementsAndChangesInAccountingPrinciplesTextBlock" xlink:label="loc_us-gaap_ScheduleOfNewAccountingPronouncementsAndChangesInAccountingPrinciplesTextBlock_65A58104E13A536892A9A5DAF5CDDC25" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_C141BC3260D1F7E01920A5DAF5CD36F3" xlink:to="loc_us-gaap_ScheduleOfNewAccountingPronouncementsAndChangesInAccountingPrinciplesTextBlock_65A58104E13A536892A9A5DAF5CDDC25" xlink:type="arc" />
  </definitionLink>
  <definitionLink xlink:role="http://www.lilly.com/role/IncomeTaxes" xlink:type="extended" />
  <definitionLink xlink:role="http://www.lilly.com/role/IncomeTaxesIncomeTaxesDetails" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_IncomeTaxExaminationLineItems" xlink:label="loc_us-gaap_IncomeTaxExaminationLineItems_ADF5B995371B60E583D3A5DAF573F5D1" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_IncomeTaxExaminationTable" xlink:label="loc_us-gaap_IncomeTaxExaminationTable_66DF18A9B0FD359D8927A5DAF573366F" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_IncomeTaxExaminationLineItems_ADF5B995371B60E583D3A5DAF573F5D1" xlink:to="loc_us-gaap_IncomeTaxExaminationTable_66DF18A9B0FD359D8927A5DAF573366F" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_IncomeTaxAuthorityAxis" xlink:label="loc_us-gaap_IncomeTaxAuthorityAxis_84F0F22DD05EC29F06D6A5DAF573D22C" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_IncomeTaxExaminationTable_66DF18A9B0FD359D8927A5DAF573366F" xlink:to="loc_us-gaap_IncomeTaxAuthorityAxis_84F0F22DD05EC29F06D6A5DAF573D22C" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_IncomeTaxAuthorityDomain" xlink:label="loc_us-gaap_IncomeTaxAuthorityDomain_84B68722C7EE0AF91D82A5DAF57384E7_default" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_IncomeTaxAuthorityAxis_84F0F22DD05EC29F06D6A5DAF573D22C" xlink:to="loc_us-gaap_IncomeTaxAuthorityDomain_84B68722C7EE0AF91D82A5DAF57384E7_default" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_IncomeTaxAuthorityDomain" xlink:label="loc_us-gaap_IncomeTaxAuthorityDomain_84B68722C7EE0AF91D82A5DAF57384E7" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_IncomeTaxAuthorityAxis_84F0F22DD05EC29F06D6A5DAF573D22C" xlink:to="loc_us-gaap_IncomeTaxAuthorityDomain_84B68722C7EE0AF91D82A5DAF57384E7" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_IncomeTaxExaminationYearUnderExamination" xlink:label="loc_us-gaap_IncomeTaxExaminationYearUnderExamination_964ED5AACB9728BC37B3A5DAF573B852" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeTaxExaminationLineItems_ADF5B995371B60E583D3A5DAF573F5D1" xlink:to="loc_us-gaap_IncomeTaxExaminationYearUnderExamination_964ED5AACB9728BC37B3A5DAF573B852" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_UnrecognizedTaxBenefitsDecreasesResultingFromSettlementsWithTaxingAuthorities" xlink:label="loc_us-gaap_UnrecognizedTaxBenefitsDecreasesResultingFromSettlementsWithTaxingAuthorities_02719EAAD9AE30F50407A5DAF57478B9" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeTaxExaminationLineItems_ADF5B995371B60E583D3A5DAF573F5D1" xlink:to="loc_us-gaap_UnrecognizedTaxBenefitsDecreasesResultingFromSettlementsWithTaxingAuthorities_02719EAAD9AE30F50407A5DAF57478B9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_IncomeTaxesPaid" xlink:label="loc_us-gaap_IncomeTaxesPaid_8E981095546E646EED88A5DAF574C124" xlink:type="locator" />
    <definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeTaxExaminationLineItems_ADF5B995371B60E583D3A5DAF573F5D1" xlink:to="loc_us-gaap_IncomeTaxesPaid_8E981095546E646EED88A5DAF574C124" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_IncomeTaxExaminationEstimateofCashPaymentforTaxesfromSettlementwithTaxingAuthority" xlink:label="loc_lly_IncomeTaxExaminationEstimateofCashPaymentforTaxesfromSettlementwithTaxingAuthority_F6F531F77EA4908C52FFA5DAF574CE83" xlink:type="locator" />
    <definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeTaxExaminationLineItems_ADF5B995371B60E583D3A5DAF573F5D1" xlink:to="loc_lly_IncomeTaxExaminationEstimateofCashPaymentforTaxesfromSettlementwithTaxingAuthority_F6F531F77EA4908C52FFA5DAF574CE83" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_IncomeTaxExaminationLiabilityRefundAdjustmentFromSettlementWithTaxingAuthority" xlink:label="loc_us-gaap_IncomeTaxExaminationLiabilityRefundAdjustmentFromSettlementWithTaxingAuthority_ED304C6C6F1B9E14758BA5DAF57437ED" xlink:type="locator" />
    <definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeTaxExaminationLineItems_ADF5B995371B60E583D3A5DAF573F5D1" xlink:to="loc_us-gaap_IncomeTaxExaminationLiabilityRefundAdjustmentFromSettlementWithTaxingAuthority_ED304C6C6F1B9E14758BA5DAF57437ED" xlink:type="arc" />
  </definitionLink>
  <definitionLink xlink:role="http://www.lilly.com/role/OtherComprehensiveIncomeLossOtherComprehensiveIncomeLossDetails" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_6FF01926EB8E2F977242EEF392CD2863" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_StatementTable" xlink:label="loc_us-gaap_StatementTable_72F99010FA212673D0CDEEF392CB9544" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_6FF01926EB8E2F977242EEF392CD2863" xlink:to="loc_us-gaap_StatementTable_72F99010FA212673D0CDEEF392CB9544" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_StatementEquityComponentsAxis" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_5ECDE793CD7E9F683A3DEEF392CCDF27" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_72F99010FA212673D0CDEEF392CB9544" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_5ECDE793CD7E9F683A3DEEF392CCDF27" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_EquityComponentDomain" xlink:label="loc_us-gaap_EquityComponentDomain_33EE3F49FCB84F5B3C8EEEF392CCAD15_default" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_5ECDE793CD7E9F683A3DEEF392CCDF27" xlink:to="loc_us-gaap_EquityComponentDomain_33EE3F49FCB84F5B3C8EEEF392CCAD15_default" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_EquityComponentDomain" xlink:label="loc_us-gaap_EquityComponentDomain_33EE3F49FCB84F5B3C8EEEF392CCAD15" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_5ECDE793CD7E9F683A3DEEF392CCDF27" xlink:to="loc_us-gaap_EquityComponentDomain_33EE3F49FCB84F5B3C8EEEF392CCAD15" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AccumulatedTranslationAdjustmentMember" xlink:label="loc_us-gaap_AccumulatedTranslationAdjustmentMember_FCB2648B1557E5BB02AAEEF392CDAAE6" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_33EE3F49FCB84F5B3C8EEEF392CCAD15" xlink:to="loc_us-gaap_AccumulatedTranslationAdjustmentMember_FCB2648B1557E5BB02AAEEF392CDAAE6" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AccumulatedNetUnrealizedInvestmentGainLossMember" xlink:label="loc_us-gaap_AccumulatedNetUnrealizedInvestmentGainLossMember_8AD8F57AFB18171C513CEEF392CDFCFC" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_33EE3F49FCB84F5B3C8EEEF392CCAD15" xlink:to="loc_us-gaap_AccumulatedNetUnrealizedInvestmentGainLossMember_8AD8F57AFB18171C513CEEF392CDFCFC" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AccumulatedDefinedBenefitPlansAdjustmentMember" xlink:label="loc_us-gaap_AccumulatedDefinedBenefitPlansAdjustmentMember_842E117F4B7A22970F22EEF392CD91BC" xlink:type="locator" />
    <definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_33EE3F49FCB84F5B3C8EEEF392CCAD15" xlink:to="loc_us-gaap_AccumulatedDefinedBenefitPlansAdjustmentMember_842E117F4B7A22970F22EEF392CD91BC" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AccumulatedNetGainLossFromDesignatedOrQualifyingCashFlowHedgesMember" xlink:label="loc_us-gaap_AccumulatedNetGainLossFromDesignatedOrQualifyingCashFlowHedgesMember_FB19687C112113E3E689EEF392CDFC5E" xlink:type="locator" />
    <definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_33EE3F49FCB84F5B3C8EEEF392CCAD15" xlink:to="loc_us-gaap_AccumulatedNetGainLossFromDesignatedOrQualifyingCashFlowHedgesMember_FB19687C112113E3E689EEF392CDFC5E" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationReclassificationAdjustmentFromAOCIRealizedUponSaleOrLiquidationNetOfTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationReclassificationAdjustmentFromAOCIRealizedUponSaleOrLiquidationNetOfTax_2E3CC0B4F9C5C6F7F01FEEF392CE3DD8" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_6FF01926EB8E2F977242EEF392CD2863" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationReclassificationAdjustmentFromAOCIRealizedUponSaleOrLiquidationNetOfTax_2E3CC0B4F9C5C6F7F01FEEF392CE3DD8" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTranslationAdjustmentTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTranslationAdjustmentTax_CBE5E68AC533B5624D07EEF392CE7E67" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_6FF01926EB8E2F977242EEF392CD2863" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTranslationAdjustmentTax_CBE5E68AC533B5624D07EEF392CE7E67" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossAmortizationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansForNetPriorServiceCostCreditBeforeTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossAmortizationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansForNetPriorServiceCostCreditBeforeTax_6BC4041FC62FF02A4B9AEEF392CE64F1" xlink:type="locator" />
    <definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_6FF01926EB8E2F977242EEF392CD2863" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossAmortizationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansForNetPriorServiceCostCreditBeforeTax_6BC4041FC62FF02A4B9AEEF392CE64F1" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_F8AB405B4D69833940FDEEF392CE8E86" xlink:type="locator" />
    <definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_6FF01926EB8E2F977242EEF392CD2863" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_F8AB405B4D69833940FDEEF392CE8E86" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossBeforeReclassificationsNetOfTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossBeforeReclassificationsNetOfTax_31CE0792BFF82C12A71EEEF392CE5FBA" xlink:type="locator" />
    <definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_6FF01926EB8E2F977242EEF392CD2863" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossBeforeReclassificationsNetOfTax_31CE0792BFF82C12A71EEEF392CE5FBA" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTax" xlink:label="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTax_F7D74A909EEC39CDF179EEF392CE0B19" xlink:type="locator" />
    <definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_6FF01926EB8E2F977242EEF392CD2863" xlink:to="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTax_F7D74A909EEC39CDF179EEF392CE0B19" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_E30F724E811EC52C492BEEF392CE1BCE" xlink:type="locator" />
    <definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_6FF01926EB8E2F977242EEF392CD2863" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_E30F724E811EC52C492BEEF392CE1BCE" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansForNetGainLossBeforeTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansForNetGainLossBeforeTax_15AE200A2C4197124EDDEEF392CEE390" xlink:type="locator" />
    <definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_6FF01926EB8E2F977242EEF392CD2863" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansForNetGainLossBeforeTax_15AE200A2C4197124EDDEEF392CEE390" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansBeforeTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansBeforeTax_6C387508337C320F5B16EEF392CEEAD7" xlink:type="locator" />
    <definitionArc order="9" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_6FF01926EB8E2F977242EEF392CD2863" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansBeforeTax_6C387508337C320F5B16EEF392CEEAD7" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansTax_0F3E835AFF328F09CDECEEF392CE4561" xlink:type="locator" />
    <definitionArc order="10" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_6FF01926EB8E2F977242EEF392CD2863" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansTax_0F3E835AFF328F09CDECEEF392CE4561" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansNetOfTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansNetOfTax_11817F43F720815BA09DEEF392CE427F" xlink:type="locator" />
    <definitionArc order="11" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_6FF01926EB8E2F977242EEF392CD2863" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansNetOfTax_11817F43F720815BA09DEEF392CE427F" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesBeforeTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesBeforeTax_F41F9F3D20841B2281B1EEF392CF8969" xlink:type="locator" />
    <definitionArc order="12" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_6FF01926EB8E2F977242EEF392CD2863" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesBeforeTax_F41F9F3D20841B2281B1EEF392CF8969" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForWritedownOfSecuritiesBeforeTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForWritedownOfSecuritiesBeforeTax_E66F9D3453813D7D8E12EEF392CF947C" xlink:type="locator" />
    <definitionArc order="13" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_6FF01926EB8E2F977242EEF392CD2863" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForWritedownOfSecuritiesBeforeTax_E66F9D3453813D7D8E12EEF392CF947C" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentBeforeTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentBeforeTax_9424AE0B1CAE92511D9AEEF392CF1644" xlink:type="locator" />
    <definitionArc order="14" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_6FF01926EB8E2F977242EEF392CD2863" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentBeforeTax_9424AE0B1CAE92511D9AEEF392CF1644" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesTax_74AD9249A204C4DAE1B9EEF392CF5D7C" xlink:type="locator" />
    <definitionArc order="15" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_6FF01926EB8E2F977242EEF392CD2863" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesTax_74AD9249A204C4DAE1B9EEF392CF5D7C" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesNetOfTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesNetOfTax_B1AA372ACDE97EF6D681EEF392CF6E57" xlink:type="locator" />
    <definitionArc order="16" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_6FF01926EB8E2F977242EEF392CD2863" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesNetOfTax_B1AA372ACDE97EF6D681EEF392CF6E57" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodTax_CC697DE484F165005A55EEF392CF9A4E" xlink:type="locator" />
    <definitionArc order="17" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_6FF01926EB8E2F977242EEF392CD2863" xlink:to="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodTax_CC697DE484F165005A55EEF392CF9A4E" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansBeforeReclassificationAdjustmentsTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansBeforeReclassificationAdjustmentsTax_FD4C121BC0A66940B515EEF392CFD4F8" xlink:type="locator" />
    <definitionArc order="18" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_6FF01926EB8E2F977242EEF392CD2863" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansBeforeReclassificationAdjustmentsTax_FD4C121BC0A66940B515EEF392CFD4F8" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_OtherComprehensiveIncomeOtherNetOfTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeOtherNetOfTax_A0E378E4764ABBDDD60BEEF392CF10A7" xlink:type="locator" />
    <definitionArc order="19" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_6FF01926EB8E2F977242EEF392CD2863" xlink:to="loc_us-gaap_OtherComprehensiveIncomeOtherNetOfTax_A0E378E4764ABBDDD60BEEF392CF10A7" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_OtherComprehensiveIncomeUnrealizedGainLossOnDerivativesArisingDuringPeriodTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeUnrealizedGainLossOnDerivativesArisingDuringPeriodTax_DA116D1D74FFCF16CAECEEF392CF389E" xlink:type="locator" />
    <definitionArc order="20" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_6FF01926EB8E2F977242EEF392CD2863" xlink:to="loc_us-gaap_OtherComprehensiveIncomeUnrealizedGainLossOnDerivativesArisingDuringPeriodTax_DA116D1D74FFCF16CAECEEF392CF389E" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossTax_5944F83F0463BA2570ACEEF392CF9466" xlink:type="locator" />
    <definitionArc order="21" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_6FF01926EB8E2F977242EEF392CD2863" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossTax_5944F83F0463BA2570ACEEF392CF9466" xlink:type="arc" />
  </definitionLink>
  <definitionLink xlink:role="http://www.lilly.com/role/OtherComprehensiveIncomeLossOtherComprehensiveIncomeLossNotes" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_5E416677C66E46657D34A5DAF52A1264" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_StatementTable" xlink:label="loc_us-gaap_StatementTable_AD204C9387E91EFB9BBBA5DAF529FA81" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_5E416677C66E46657D34A5DAF52A1264" xlink:to="loc_us-gaap_StatementTable_AD204C9387E91EFB9BBBA5DAF529FA81" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_StatementScenarioAxis" xlink:label="loc_us-gaap_StatementScenarioAxis_F7A6AC3EA1061C75766EA5DAF5294334" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_AD204C9387E91EFB9BBBA5DAF529FA81" xlink:to="loc_us-gaap_StatementScenarioAxis_F7A6AC3EA1061C75766EA5DAF5294334" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ScenarioUnspecifiedDomain" xlink:label="loc_us-gaap_ScenarioUnspecifiedDomain_0199CE57D029175A3DFBA5DAF52A38E3_default" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementScenarioAxis_F7A6AC3EA1061C75766EA5DAF5294334" xlink:to="loc_us-gaap_ScenarioUnspecifiedDomain_0199CE57D029175A3DFBA5DAF52A38E3_default" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ScenarioUnspecifiedDomain" xlink:label="loc_us-gaap_ScenarioUnspecifiedDomain_0199CE57D029175A3DFBA5DAF52A38E3" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementScenarioAxis_F7A6AC3EA1061C75766EA5DAF5294334" xlink:to="loc_us-gaap_ScenarioUnspecifiedDomain_0199CE57D029175A3DFBA5DAF52A38E3" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ComprehensiveIncomeNoteTextBlock" xlink:label="loc_us-gaap_ComprehensiveIncomeNoteTextBlock_4ECFC89903ACFADF2735A5DAF52AF357" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_5E416677C66E46657D34A5DAF52A1264" xlink:to="loc_us-gaap_ComprehensiveIncomeNoteTextBlock_4ECFC89903ACFADF2735A5DAF52AF357" xlink:type="arc" />
  </definitionLink>
  <definitionLink xlink:role="http://www.lilly.com/role/OtherComprehensiveIncomeLossOtherComprehensiveIncomeLossTables" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_BBE21A264286B599ED802CFFB402A8C8" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossTable" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_9717DED65DC59ED3A61C2CFFB401BCCD" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_BBE21A264286B599ED802CFFB402A8C8" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_9717DED65DC59ED3A61C2CFFB401BCCD" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_StatementEquityComponentsAxis" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_F7D63875CE3E946AAD3A2CFFB40279E5" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_9717DED65DC59ED3A61C2CFFB401BCCD" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_F7D63875CE3E946AAD3A2CFFB40279E5" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_EquityComponentDomain" xlink:label="loc_us-gaap_EquityComponentDomain_37CB6B586D0660AD45822CFFB4023746_default" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_F7D63875CE3E946AAD3A2CFFB40279E5" xlink:to="loc_us-gaap_EquityComponentDomain_37CB6B586D0660AD45822CFFB4023746_default" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_EquityComponentDomain" xlink:label="loc_us-gaap_EquityComponentDomain_37CB6B586D0660AD45822CFFB4023746" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_F7D63875CE3E946AAD3A2CFFB40279E5" xlink:to="loc_us-gaap_EquityComponentDomain_37CB6B586D0660AD45822CFFB4023746" xlink:type="arc" />
  </definitionLink>
  <definitionLink xlink:role="http://www.lilly.com/role/OtherNetIncomeExpense" xlink:type="extended" />
  <definitionLink xlink:role="http://www.lilly.com/role/OtherNetIncomeExpenseDetails" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_4CEF8F0A6A5DFBA2D99A325BED261C4C" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_StatementTable" xlink:label="loc_us-gaap_StatementTable_FB5729F9A907AACB0783325BED20C2C6" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_4CEF8F0A6A5DFBA2D99A325BED261C4C" xlink:to="loc_us-gaap_StatementTable_FB5729F9A907AACB0783325BED20C2C6" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_StatementGeographicalAxis" xlink:label="loc_us-gaap_StatementGeographicalAxis_534B9B836B95AB4E696B325BED201B66" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_FB5729F9A907AACB0783325BED20C2C6" xlink:to="loc_us-gaap_StatementGeographicalAxis_534B9B836B95AB4E696B325BED201B66" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SegmentGeographicalDomain" xlink:label="loc_us-gaap_SegmentGeographicalDomain_E0D31B5D1E28C9A91A26325BED21B2BA_default" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementGeographicalAxis_534B9B836B95AB4E696B325BED201B66" xlink:to="loc_us-gaap_SegmentGeographicalDomain_E0D31B5D1E28C9A91A26325BED21B2BA_default" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SegmentGeographicalDomain" xlink:label="loc_us-gaap_SegmentGeographicalDomain_E0D31B5D1E28C9A91A26325BED21B2BA" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementGeographicalAxis_534B9B836B95AB4E696B325BED201B66" xlink:to="loc_us-gaap_SegmentGeographicalDomain_E0D31B5D1E28C9A91A26325BED21B2BA" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ProductOrServiceAxis" xlink:label="loc_us-gaap_ProductOrServiceAxis_30AE1BCE131126930F0C325BED21341B" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_FB5729F9A907AACB0783325BED20C2C6" xlink:to="loc_us-gaap_ProductOrServiceAxis_30AE1BCE131126930F0C325BED21341B" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ProductsAndServicesDomain" xlink:label="loc_us-gaap_ProductsAndServicesDomain_49C5AF307DC203D140A6325BED210C20_default" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ProductOrServiceAxis_30AE1BCE131126930F0C325BED21341B" xlink:to="loc_us-gaap_ProductsAndServicesDomain_49C5AF307DC203D140A6325BED210C20_default" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ProductsAndServicesDomain" xlink:label="loc_us-gaap_ProductsAndServicesDomain_49C5AF307DC203D140A6325BED210C20" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ProductOrServiceAxis_30AE1BCE131126930F0C325BED21341B" xlink:to="loc_us-gaap_ProductsAndServicesDomain_49C5AF307DC203D140A6325BED210C20" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_StatementScenarioAxis" xlink:label="loc_us-gaap_StatementScenarioAxis_E95C58425EA65ED7A81F325BED260FA3" xlink:type="locator" />
    <definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_FB5729F9A907AACB0783325BED20C2C6" xlink:to="loc_us-gaap_StatementScenarioAxis_E95C58425EA65ED7A81F325BED260FA3" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ScenarioUnspecifiedDomain" xlink:label="loc_us-gaap_ScenarioUnspecifiedDomain_ADD08BF155299C46974B325BED26FCA0_default" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementScenarioAxis_E95C58425EA65ED7A81F325BED260FA3" xlink:to="loc_us-gaap_ScenarioUnspecifiedDomain_ADD08BF155299C46974B325BED26FCA0_default" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ScenarioUnspecifiedDomain" xlink:label="loc_us-gaap_ScenarioUnspecifiedDomain_ADD08BF155299C46974B325BED26FCA0" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementScenarioAxis_E95C58425EA65ED7A81F325BED260FA3" xlink:to="loc_us-gaap_ScenarioUnspecifiedDomain_ADD08BF155299C46974B325BED26FCA0" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_InterestExpense" xlink:label="loc_us-gaap_InterestExpense_5C59A951C9743CC18768325BED277EBB" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_4CEF8F0A6A5DFBA2D99A325BED261C4C" xlink:to="loc_us-gaap_InterestExpense_5C59A951C9743CC18768325BED277EBB" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_InvestmentIncomeInterest" xlink:label="loc_us-gaap_InvestmentIncomeInterest_243D03D829B566661355325BED27DA78" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_4CEF8F0A6A5DFBA2D99A325BED261C4C" xlink:to="loc_us-gaap_InvestmentIncomeInterest_243D03D829B566661355325BED27DA78" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ForeignCurrencyTransactionGainLossRealized" xlink:label="loc_us-gaap_ForeignCurrencyTransactionGainLossRealized_F222C23AE32CAE965A91325BED27C325" xlink:type="locator" />
    <definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_4CEF8F0A6A5DFBA2D99A325BED261C4C" xlink:to="loc_us-gaap_ForeignCurrencyTransactionGainLossRealized_F222C23AE32CAE965A91325BED27C325" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_GainsLossesOnExtinguishmentOfDebt" xlink:label="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_A9533D43539F7C9B6CD7325BED27C04F" xlink:type="locator" />
    <definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_4CEF8F0A6A5DFBA2D99A325BED261C4C" xlink:to="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_A9533D43539F7C9B6CD7325BED27C04F" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_OtherNonoperatingIncomeExpense" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_E77BC65DDE3C99BEAD51325BED273425" xlink:type="locator" />
    <definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_4CEF8F0A6A5DFBA2D99A325BED261C4C" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpense_E77BC65DDE3C99BEAD51325BED273425" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_NonoperatingIncomeExpense" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_F374A609B0292D164F3F325BED27601F" xlink:type="locator" />
    <definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_4CEF8F0A6A5DFBA2D99A325BED261C4C" xlink:to="loc_us-gaap_NonoperatingIncomeExpense_F374A609B0292D164F3F325BED27601F" xlink:type="arc" />
  </definitionLink>
  <definitionLink xlink:role="http://www.lilly.com/role/OtherNetIncomeExpenseTables" xlink:type="extended" />
  <definitionLink xlink:role="http://www.lilly.com/role/RetirementBenefits" xlink:type="extended" />
  <definitionLink xlink:role="http://www.lilly.com/role/RetirementBenefitsDetails" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_499A6EB045C702CD8753A5DAF63233F1" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansDisclosuresTable" xlink:label="loc_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansDisclosuresTable_B9DFFCF73C857CBF5C2CA5DAF6323EF5" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_499A6EB045C702CD8753A5DAF63233F1" xlink:to="loc_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansDisclosuresTable_B9DFFCF73C857CBF5C2CA5DAF6323EF5" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DefinedBenefitPlansDisclosuresDefinedBenefitPlansAxis" xlink:label="loc_us-gaap_DefinedBenefitPlansDisclosuresDefinedBenefitPlansAxis_F8150F8D5AF29D76F7FCA5DAF632481E" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansDisclosuresTable_B9DFFCF73C857CBF5C2CA5DAF6323EF5" xlink:to="loc_us-gaap_DefinedBenefitPlansDisclosuresDefinedBenefitPlansAxis_F8150F8D5AF29D76F7FCA5DAF632481E" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DefinedBenefitPlansDomain" xlink:label="loc_us-gaap_DefinedBenefitPlansDomain_594C4A75A8EF76E251CBA5DAF632D799_default" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DefinedBenefitPlansDisclosuresDefinedBenefitPlansAxis_F8150F8D5AF29D76F7FCA5DAF632481E" xlink:to="loc_us-gaap_DefinedBenefitPlansDomain_594C4A75A8EF76E251CBA5DAF632D799_default" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DefinedBenefitPlansDomain" xlink:label="loc_us-gaap_DefinedBenefitPlansDomain_594C4A75A8EF76E251CBA5DAF632D799" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DefinedBenefitPlansDisclosuresDefinedBenefitPlansAxis_F8150F8D5AF29D76F7FCA5DAF632481E" xlink:to="loc_us-gaap_DefinedBenefitPlansDomain_594C4A75A8EF76E251CBA5DAF632D799" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_PensionPlansDefinedBenefitMember" xlink:label="loc_us-gaap_PensionPlansDefinedBenefitMember_1896F956C817A656B08EA5DAF632A315" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlansDomain_594C4A75A8EF76E251CBA5DAF632D799" xlink:to="loc_us-gaap_PensionPlansDefinedBenefitMember_1896F956C817A656B08EA5DAF632A315" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_OtherPostretirementBenefitPlansDefinedBenefitMember" xlink:label="loc_us-gaap_OtherPostretirementBenefitPlansDefinedBenefitMember_1C6A69897EC37CD6594EA5DAF6321642" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlansDomain_594C4A75A8EF76E251CBA5DAF632D799" xlink:to="loc_us-gaap_OtherPostretirementBenefitPlansDefinedBenefitMember_1C6A69897EC37CD6594EA5DAF6321642" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DefinedBenefitPlanServiceCost" xlink:label="loc_us-gaap_DefinedBenefitPlanServiceCost_41DFF36C6DFA5CB0B0F3A5DAF632FB29" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_499A6EB045C702CD8753A5DAF63233F1" xlink:to="loc_us-gaap_DefinedBenefitPlanServiceCost_41DFF36C6DFA5CB0B0F3A5DAF632FB29" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DefinedBenefitPlanInterestCost" xlink:label="loc_us-gaap_DefinedBenefitPlanInterestCost_0798D1DA5FFE8365B965A5DAF6326FFB" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_499A6EB045C702CD8753A5DAF63233F1" xlink:to="loc_us-gaap_DefinedBenefitPlanInterestCost_0798D1DA5FFE8365B965A5DAF6326FFB" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DefinedBenefitPlanExpectedReturnOnPlanAssets" xlink:label="loc_us-gaap_DefinedBenefitPlanExpectedReturnOnPlanAssets_C27297489B1F89E333D2A5DAF632E72D" xlink:type="locator" />
    <definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_499A6EB045C702CD8753A5DAF63233F1" xlink:to="loc_us-gaap_DefinedBenefitPlanExpectedReturnOnPlanAssets_C27297489B1F89E333D2A5DAF632E72D" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DefinedBenefitPlanAmortizationOfPriorServiceCostCredit" xlink:label="loc_us-gaap_DefinedBenefitPlanAmortizationOfPriorServiceCostCredit_904A52AC1D3F67665D62A5DAF63262FA" xlink:type="locator" />
    <definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_499A6EB045C702CD8753A5DAF63233F1" xlink:to="loc_us-gaap_DefinedBenefitPlanAmortizationOfPriorServiceCostCredit_904A52AC1D3F67665D62A5DAF63262FA" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DefinedBenefitPlanActuarialGainLoss" xlink:label="loc_us-gaap_DefinedBenefitPlanActuarialGainLoss_326F74711F755F545FBBA5DAF6324E73" xlink:type="locator" />
    <definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_499A6EB045C702CD8753A5DAF63233F1" xlink:to="loc_us-gaap_DefinedBenefitPlanActuarialGainLoss_326F74711F755F545FBBA5DAF6324E73" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost" xlink:label="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost_C02822935A545C9070A9A5DAF632FA8C" xlink:type="locator" />
    <definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_499A6EB045C702CD8753A5DAF63233F1" xlink:to="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost_C02822935A545C9070A9A5DAF632FA8C" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_PensionContributions" xlink:label="loc_us-gaap_PensionContributions_3890C92DDB197840E24CA5DAF6321A78" xlink:type="locator" />
    <definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_499A6EB045C702CD8753A5DAF63233F1" xlink:to="loc_us-gaap_PensionContributions_3890C92DDB197840E24CA5DAF6321A78" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DefinedBenefitPlansEstimatedFutureEmployerContributionsInCurrentFiscalYear" xlink:label="loc_us-gaap_DefinedBenefitPlansEstimatedFutureEmployerContributionsInCurrentFiscalYear_E4F001261170F5C96D4CA5DAF632675B" xlink:type="locator" />
    <definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_499A6EB045C702CD8753A5DAF63233F1" xlink:to="loc_us-gaap_DefinedBenefitPlansEstimatedFutureEmployerContributionsInCurrentFiscalYear_E4F001261170F5C96D4CA5DAF632675B" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_PensionAndOtherPostretirementBenefitContributionsDiscretionaryContributions" xlink:label="loc_lly_PensionAndOtherPostretirementBenefitContributionsDiscretionaryContributions_151AD9CD85FEB3CC8569A5DAF6320FDA" xlink:type="locator" />
    <definitionArc order="9" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_499A6EB045C702CD8753A5DAF63233F1" xlink:to="loc_lly_PensionAndOtherPostretirementBenefitContributionsDiscretionaryContributions_151AD9CD85FEB3CC8569A5DAF6320FDA" xlink:type="arc" />
  </definitionLink>
  <definitionLink xlink:role="http://www.lilly.com/role/RetirementBenefitsTables" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_DFB3A71A601865F4D294A5DAF578CFB2" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansDisclosuresTable" xlink:label="loc_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansDisclosuresTable_DEE55D56FBF56B452133A5DAF5770B10" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_DFB3A71A601865F4D294A5DAF578CFB2" xlink:to="loc_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansDisclosuresTable_DEE55D56FBF56B452133A5DAF5770B10" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DefinedBenefitPlansDisclosuresDefinedBenefitPlansAxis" xlink:label="loc_us-gaap_DefinedBenefitPlansDisclosuresDefinedBenefitPlansAxis_CB0704E321832D95339BA5DAF5772E35" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansDisclosuresTable_DEE55D56FBF56B452133A5DAF5770B10" xlink:to="loc_us-gaap_DefinedBenefitPlansDisclosuresDefinedBenefitPlansAxis_CB0704E321832D95339BA5DAF5772E35" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DefinedBenefitPlansDomain" xlink:label="loc_us-gaap_DefinedBenefitPlansDomain_15F107E4C96B10C13938A5DAF5770537_default" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DefinedBenefitPlansDisclosuresDefinedBenefitPlansAxis_CB0704E321832D95339BA5DAF5772E35" xlink:to="loc_us-gaap_DefinedBenefitPlansDomain_15F107E4C96B10C13938A5DAF5770537_default" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DefinedBenefitPlansDomain" xlink:label="loc_us-gaap_DefinedBenefitPlansDomain_15F107E4C96B10C13938A5DAF5770537" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DefinedBenefitPlansDisclosuresDefinedBenefitPlansAxis_CB0704E321832D95339BA5DAF5772E35" xlink:to="loc_us-gaap_DefinedBenefitPlansDomain_15F107E4C96B10C13938A5DAF5770537" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_PensionPlansDefinedBenefitMember" xlink:label="loc_us-gaap_PensionPlansDefinedBenefitMember_AF6A3D680E1D5880EDE8A5DAF57829C7" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlansDomain_15F107E4C96B10C13938A5DAF5770537" xlink:to="loc_us-gaap_PensionPlansDefinedBenefitMember_AF6A3D680E1D5880EDE8A5DAF57829C7" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_OtherPostretirementBenefitPlansDefinedBenefitMember" xlink:label="loc_us-gaap_OtherPostretirementBenefitPlansDefinedBenefitMember_1F649FF3F8DF81786FCDA5DAF578F78B" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlansDomain_15F107E4C96B10C13938A5DAF5770537" xlink:to="loc_us-gaap_OtherPostretirementBenefitPlansDefinedBenefitMember_1F649FF3F8DF81786FCDA5DAF578F78B" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ScheduleOfNetBenefitCostsTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfNetBenefitCostsTableTextBlock_85A1354B9003F43ACA6AA5DAF578B24D" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_DFB3A71A601865F4D294A5DAF578CFB2" xlink:to="loc_us-gaap_ScheduleOfNetBenefitCostsTableTextBlock_85A1354B9003F43ACA6AA5DAF578B24D" xlink:type="arc" />
  </definitionLink>
  <definitionLink xlink:role="http://www.lilly.com/role/SegmentInformation" xlink:type="extended" />
  <definitionLink xlink:role="http://www.lilly.com/role/SegmentInformationDetails" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_B41C345C58DF72A23295325BECEA33D8" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable" xlink:label="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_C2C66091F3E684BE907E325BECE00C1E" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_B41C345C58DF72A23295325BECEA33D8" xlink:to="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_C2C66091F3E684BE907E325BECE00C1E" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_BusinessAcquisitionAxis" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_BA95D076AB0D53D0BF36325BECE0E448" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_C2C66091F3E684BE907E325BECE00C1E" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_BA95D076AB0D53D0BF36325BECE0E448" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_1C51AD66EDAD5C7BE220325BECE0A2F9_default" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_BA95D076AB0D53D0BF36325BECE0E448" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_1C51AD66EDAD5C7BE220325BECE0A2F9_default" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_1C51AD66EDAD5C7BE220325BECE0A2F9" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_BA95D076AB0D53D0BF36325BECE0E448" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_1C51AD66EDAD5C7BE220325BECE0A2F9" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_ErbituxAcquisitionMember" xlink:label="loc_lly_ErbituxAcquisitionMember_7284FB529B4F97B35F7F325BECE0A21F" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_1C51AD66EDAD5C7BE220325BECE0A2F9" xlink:to="loc_lly_ErbituxAcquisitionMember_7284FB529B4F97B35F7F325BECE0A21F" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_StatementGeographicalAxis" xlink:label="loc_us-gaap_StatementGeographicalAxis_1F3ED013CB89841AF3A5325BECE1C88A" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_C2C66091F3E684BE907E325BECE00C1E" xlink:to="loc_us-gaap_StatementGeographicalAxis_1F3ED013CB89841AF3A5325BECE1C88A" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SegmentGeographicalDomain" xlink:label="loc_us-gaap_SegmentGeographicalDomain_C46D97128D89D02AAD4C325BECE1783E_default" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementGeographicalAxis_1F3ED013CB89841AF3A5325BECE1C88A" xlink:to="loc_us-gaap_SegmentGeographicalDomain_C46D97128D89D02AAD4C325BECE1783E_default" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SegmentGeographicalDomain" xlink:label="loc_us-gaap_SegmentGeographicalDomain_C46D97128D89D02AAD4C325BECE1783E" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementGeographicalAxis_1F3ED013CB89841AF3A5325BECE1C88A" xlink:to="loc_us-gaap_SegmentGeographicalDomain_C46D97128D89D02AAD4C325BECE1783E" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ExtinguishmentOfDebtAxis" xlink:label="loc_us-gaap_ExtinguishmentOfDebtAxis_25703860A4CE4F46ABEB325BECE18C01" xlink:type="locator" />
    <definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_C2C66091F3E684BE907E325BECE00C1E" xlink:to="loc_us-gaap_ExtinguishmentOfDebtAxis_25703860A4CE4F46ABEB325BECE18C01" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ExtinguishmentOfDebtTypeDomain" xlink:label="loc_us-gaap_ExtinguishmentOfDebtTypeDomain_3D394720DFC84C6975AB325BECE1130F_default" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ExtinguishmentOfDebtAxis_25703860A4CE4F46ABEB325BECE18C01" xlink:to="loc_us-gaap_ExtinguishmentOfDebtTypeDomain_3D394720DFC84C6975AB325BECE1130F_default" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ExtinguishmentOfDebtTypeDomain" xlink:label="loc_us-gaap_ExtinguishmentOfDebtTypeDomain_3D394720DFC84C6975AB325BECE1130F" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ExtinguishmentOfDebtAxis_25703860A4CE4F46ABEB325BECE18C01" xlink:to="loc_us-gaap_ExtinguishmentOfDebtTypeDomain_3D394720DFC84C6975AB325BECE1130F" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LongTermDebtMember" xlink:label="loc_us-gaap_LongTermDebtMember_DEF341C1BCD7138F85AB325BECE25485" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ExtinguishmentOfDebtTypeDomain_3D394720DFC84C6975AB325BECE1130F" xlink:to="loc_us-gaap_LongTermDebtMember_DEF341C1BCD7138F85AB325BECE25485" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_NonrecurringAdjustmentAxis" xlink:label="loc_us-gaap_NonrecurringAdjustmentAxis_AED2C744866251279D02325BECE2E6AF" xlink:type="locator" />
    <definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_C2C66091F3E684BE907E325BECE00C1E" xlink:to="loc_us-gaap_NonrecurringAdjustmentAxis_AED2C744866251279D02325BECE2E6AF" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_NonrecurringAdjustmentDomain" xlink:label="loc_us-gaap_NonrecurringAdjustmentDomain_ECFBC8888A2D1230C067325BECE2F374_default" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_NonrecurringAdjustmentAxis_AED2C744866251279D02325BECE2E6AF" xlink:to="loc_us-gaap_NonrecurringAdjustmentDomain_ECFBC8888A2D1230C067325BECE2F374_default" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_NonrecurringAdjustmentDomain" xlink:label="loc_us-gaap_NonrecurringAdjustmentDomain_ECFBC8888A2D1230C067325BECE2F374" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_NonrecurringAdjustmentAxis_AED2C744866251279D02325BECE2E6AF" xlink:to="loc_us-gaap_NonrecurringAdjustmentDomain_ECFBC8888A2D1230C067325BECE2F374" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FairValueAdjustmentToInventoryMember" xlink:label="loc_us-gaap_FairValueAdjustmentToInventoryMember_B4693A36120F8CC7BB1E325BECE206A4" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NonrecurringAdjustmentDomain_ECFBC8888A2D1230C067325BECE2F374" xlink:to="loc_us-gaap_FairValueAdjustmentToInventoryMember_B4693A36120F8CC7BB1E325BECE206A4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ProductOrServiceAxis" xlink:label="loc_us-gaap_ProductOrServiceAxis_72D4F33200EAFDD0950F325BECE292EA" xlink:type="locator" />
    <definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_C2C66091F3E684BE907E325BECE00C1E" xlink:to="loc_us-gaap_ProductOrServiceAxis_72D4F33200EAFDD0950F325BECE292EA" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ProductsAndServicesDomain" xlink:label="loc_us-gaap_ProductsAndServicesDomain_0EA8E056B52AD00EAEC9325BECE25DB7_default" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ProductOrServiceAxis_72D4F33200EAFDD0950F325BECE292EA" xlink:to="loc_us-gaap_ProductsAndServicesDomain_0EA8E056B52AD00EAEC9325BECE25DB7_default" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ProductsAndServicesDomain" xlink:label="loc_us-gaap_ProductsAndServicesDomain_0EA8E056B52AD00EAEC9325BECE25DB7" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ProductOrServiceAxis_72D4F33200EAFDD0950F325BECE292EA" xlink:to="loc_us-gaap_ProductsAndServicesDomain_0EA8E056B52AD00EAEC9325BECE25DB7" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_OtherPharmaceuticalsMember" xlink:label="loc_lly_OtherPharmaceuticalsMember_7A616C29115246D03E0C325BECE33AA3" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ProductsAndServicesDomain_0EA8E056B52AD00EAEC9325BECE25DB7" xlink:to="loc_lly_OtherPharmaceuticalsMember_7A616C29115246D03E0C325BECE33AA3" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_OtherEndocrinologyMember" xlink:label="loc_lly_OtherEndocrinologyMember_9DD3373B51A8E01B0AF1325BECE3E5A9" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ProductsAndServicesDomain_0EA8E056B52AD00EAEC9325BECE25DB7" xlink:to="loc_lly_OtherEndocrinologyMember_9DD3373B51A8E01B0AF1325BECE3E5A9" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_EndocrinologyMember" xlink:label="loc_lly_EndocrinologyMember_2482617B252D8BCB9EED325BECE3584D" xlink:type="locator" />
    <definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ProductsAndServicesDomain_0EA8E056B52AD00EAEC9325BECE25DB7" xlink:to="loc_lly_EndocrinologyMember_2482617B252D8BCB9EED325BECE3584D" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_HumalogMember" xlink:label="loc_lly_HumalogMember_635B0051F3601F371456325BECE35C3D" xlink:type="locator" />
    <definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ProductsAndServicesDomain_0EA8E056B52AD00EAEC9325BECE25DB7" xlink:to="loc_lly_HumalogMember_635B0051F3601F371456325BECE35C3D" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_HumulinMember" xlink:label="loc_lly_HumulinMember_E58D2E66CD690D67A0E0325BECE82827" xlink:type="locator" />
    <definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ProductsAndServicesDomain_0EA8E056B52AD00EAEC9325BECE25DB7" xlink:to="loc_lly_HumulinMember_E58D2E66CD690D67A0E0325BECE82827" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_ForteoMember" xlink:label="loc_lly_ForteoMember_76D912D66A8ED018DBE1325BECE95658" xlink:type="locator" />
    <definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ProductsAndServicesDomain_0EA8E056B52AD00EAEC9325BECE25DB7" xlink:to="loc_lly_ForteoMember_76D912D66A8ED018DBE1325BECE95658" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_TrulicityMemberMember" xlink:label="loc_lly_TrulicityMemberMember_D1A75DCDBE93AA89DA21325BECE90A82" xlink:type="locator" />
    <definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ProductsAndServicesDomain_0EA8E056B52AD00EAEC9325BECE25DB7" xlink:to="loc_lly_TrulicityMemberMember_D1A75DCDBE93AA89DA21325BECE90A82" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_TrajentaBIMember" xlink:label="loc_lly_TrajentaBIMember_47285DDBE7C64C06F3A5325BECE9541F" xlink:type="locator" />
    <definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ProductsAndServicesDomain_0EA8E056B52AD00EAEC9325BECE25DB7" xlink:to="loc_lly_TrajentaBIMember_47285DDBE7C64C06F3A5325BECE9541F" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_CymbaltaMember" xlink:label="loc_lly_CymbaltaMember_393EB20D2B94423C8269325BECE93601" xlink:type="locator" />
    <definitionArc order="9" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ProductsAndServicesDomain_0EA8E056B52AD00EAEC9325BECE25DB7" xlink:to="loc_lly_CymbaltaMember_393EB20D2B94423C8269325BECE93601" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_ZyprexaMember" xlink:label="loc_lly_ZyprexaMember_914EFE2499AA4B494388325BECE9ED10" xlink:type="locator" />
    <definitionArc order="10" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ProductsAndServicesDomain_0EA8E056B52AD00EAEC9325BECE25DB7" xlink:to="loc_lly_ZyprexaMember_914EFE2499AA4B494388325BECE9ED10" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_StratteraMember" xlink:label="loc_lly_StratteraMember_A27ADF74E40C7FCA58A7325BECE94ADE" xlink:type="locator" />
    <definitionArc order="11" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ProductsAndServicesDomain_0EA8E056B52AD00EAEC9325BECE25DB7" xlink:to="loc_lly_StratteraMember_A27ADF74E40C7FCA58A7325BECE94ADE" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_OtherNeuroscienceMember" xlink:label="loc_lly_OtherNeuroscienceMember_5160BD45930763FE5BAA325BECE9F018" xlink:type="locator" />
    <definitionArc order="12" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ProductsAndServicesDomain_0EA8E056B52AD00EAEC9325BECE25DB7" xlink:to="loc_lly_OtherNeuroscienceMember_5160BD45930763FE5BAA325BECE9F018" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_NeuroscienceMember" xlink:label="loc_lly_NeuroscienceMember_0E0599D5FA013807F125325BECE98EDD" xlink:type="locator" />
    <definitionArc order="13" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ProductsAndServicesDomain_0EA8E056B52AD00EAEC9325BECE25DB7" xlink:to="loc_lly_NeuroscienceMember_0E0599D5FA013807F125325BECE98EDD" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_AlimtaMember" xlink:label="loc_lly_AlimtaMember_6A818ADB068699979CD2325BECE95E2F" xlink:type="locator" />
    <definitionArc order="14" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ProductsAndServicesDomain_0EA8E056B52AD00EAEC9325BECE25DB7" xlink:to="loc_lly_AlimtaMember_6A818ADB068699979CD2325BECE95E2F" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_ErbituxMember" xlink:label="loc_lly_ErbituxMember_E06A6C3079FE5FBC918C325BECE93D39" xlink:type="locator" />
    <definitionArc order="15" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ProductsAndServicesDomain_0EA8E056B52AD00EAEC9325BECE25DB7" xlink:to="loc_lly_ErbituxMember_E06A6C3079FE5FBC918C325BECE93D39" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_EffientMember" xlink:label="loc_lly_EffientMember_74556A0E70C4851D2380325BECEA38CB" xlink:type="locator" />
    <definitionArc order="16" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ProductsAndServicesDomain_0EA8E056B52AD00EAEC9325BECE25DB7" xlink:to="loc_lly_EffientMember_74556A0E70C4851D2380325BECEA38CB" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_OtherOncologyMember" xlink:label="loc_lly_OtherOncologyMember_323F7F8F95FC71229569325BECEAD0F1" xlink:type="locator" />
    <definitionArc order="17" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ProductsAndServicesDomain_0EA8E056B52AD00EAEC9325BECE25DB7" xlink:to="loc_lly_OtherOncologyMember_323F7F8F95FC71229569325BECEAD0F1" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_OncologyMember" xlink:label="loc_lly_OncologyMember_07F5EFD28A88FAA63132325BECEAF565" xlink:type="locator" />
    <definitionArc order="18" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ProductsAndServicesDomain_0EA8E056B52AD00EAEC9325BECE25DB7" xlink:to="loc_lly_OncologyMember_07F5EFD28A88FAA63132325BECEAF565" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_CialisMember" xlink:label="loc_lly_CialisMember_1D1DC442ED70E40280A6325BECEA2190" xlink:type="locator" />
    <definitionArc order="19" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ProductsAndServicesDomain_0EA8E056B52AD00EAEC9325BECE25DB7" xlink:to="loc_lly_CialisMember_1D1DC442ED70E40280A6325BECEA2190" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_OtherCardiovascularMember" xlink:label="loc_lly_OtherCardiovascularMember_15F41E97612AA93251B9325BECEAB3C4" xlink:type="locator" />
    <definitionArc order="20" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ProductsAndServicesDomain_0EA8E056B52AD00EAEC9325BECE25DB7" xlink:to="loc_lly_OtherCardiovascularMember_15F41E97612AA93251B9325BECEAB3C4" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_CardiovascularMember" xlink:label="loc_lly_CardiovascularMember_09DEEBAD3F51AF3B5FCB325BECEADEFF" xlink:type="locator" />
    <definitionArc order="21" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ProductsAndServicesDomain_0EA8E056B52AD00EAEC9325BECE25DB7" xlink:to="loc_lly_CardiovascularMember_09DEEBAD3F51AF3B5FCB325BECEADEFF" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_CyramzaMember" xlink:label="loc_lly_CyramzaMember_6EC7528290915A95A69C325BECEABC96" xlink:type="locator" />
    <definitionArc order="22" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ProductsAndServicesDomain_0EA8E056B52AD00EAEC9325BECE25DB7" xlink:to="loc_lly_CyramzaMember_6EC7528290915A95A69C325BECEABC96" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_StatementBusinessSegmentsAxis" xlink:label="loc_us-gaap_StatementBusinessSegmentsAxis_0483504C72AD7039B4B7325BECEAF808" xlink:type="locator" />
    <definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_C2C66091F3E684BE907E325BECE00C1E" xlink:to="loc_us-gaap_StatementBusinessSegmentsAxis_0483504C72AD7039B4B7325BECEAF808" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SegmentDomain" xlink:label="loc_us-gaap_SegmentDomain_85349EFC3F07D2E3EB61325BECEA1C0D_default" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_0483504C72AD7039B4B7325BECEAF808" xlink:to="loc_us-gaap_SegmentDomain_85349EFC3F07D2E3EB61325BECEA1C0D_default" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SegmentDomain" xlink:label="loc_us-gaap_SegmentDomain_85349EFC3F07D2E3EB61325BECEA1C0D" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_0483504C72AD7039B4B7325BECEAF808" xlink:to="loc_us-gaap_SegmentDomain_85349EFC3F07D2E3EB61325BECEA1C0D" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_AnimalHealthMember" xlink:label="loc_lly_AnimalHealthMember_AA6EB5DA92FF5097CA7C325BECEAC2C8" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_85349EFC3F07D2E3EB61325BECEA1C0D" xlink:to="loc_lly_AnimalHealthMember_AA6EB5DA92FF5097CA7C325BECEAC2C8" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_AnimalHealthProductsMember" xlink:label="loc_lly_AnimalHealthProductsMember_96219242E674569C2EBB325BECEA2C8A" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_85349EFC3F07D2E3EB61325BECEA1C0D" xlink:to="loc_lly_AnimalHealthProductsMember_96219242E674569C2EBB325BECEA2C8A" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_HumanPharmaceuticalProductsMember" xlink:label="loc_lly_HumanPharmaceuticalProductsMember_8E5F57C10DEF1D607857325BECEA98B8" xlink:type="locator" />
    <definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_85349EFC3F07D2E3EB61325BECEA1C0D" xlink:to="loc_lly_HumanPharmaceuticalProductsMember_8E5F57C10DEF1D607857325BECEA98B8" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_OperatingSegmentsMember" xlink:label="loc_us-gaap_OperatingSegmentsMember_16C6A21CFDF7B34874B8325BECEA22E5" xlink:type="locator" />
    <definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_85349EFC3F07D2E3EB61325BECEA1C0D" xlink:to="loc_us-gaap_OperatingSegmentsMember_16C6A21CFDF7B34874B8325BECEA22E5" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CorporateNonSegmentMember" xlink:label="loc_us-gaap_CorporateNonSegmentMember_1B8C057346365CCF988C325BECEA1BD6" xlink:type="locator" />
    <definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_85349EFC3F07D2E3EB61325BECEA1C0D" xlink:to="loc_us-gaap_CorporateNonSegmentMember_1B8C057346365CCF988C325BECEA1BD6" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_Depreciation" xlink:label="loc_us-gaap_Depreciation_56E8BA82486213C04969325BECF0A799" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_B41C345C58DF72A23295325BECEA33D8" xlink:to="loc_us-gaap_Depreciation_56E8BA82486213C04969325BECF0A799" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_Revenues" xlink:label="loc_us-gaap_Revenues_84E855915899BD0E4C9A325BECF08CEB" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_B41C345C58DF72A23295325BECEA33D8" xlink:to="loc_us-gaap_Revenues_84E855915899BD0E4C9A325BECF08CEB" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_OtherSalesRevenueNet" xlink:label="loc_us-gaap_OtherSalesRevenueNet_92FF1A25646893093081325BECF0319C" xlink:type="locator" />
    <definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_B41C345C58DF72A23295325BECEA33D8" xlink:to="loc_us-gaap_OtherSalesRevenueNet_92FF1A25646893093081325BECF0319C" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_6A4E0DC241F35639C00C325BECF05327" xlink:type="locator" />
    <definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_B41C345C58DF72A23295325BECEA33D8" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_6A4E0DC241F35639C00C325BECF05327" xlink:type="arc" />
    <loc xlink:href="lly-20160630.xsd#lly_AcquiredInProcessResearchAndDevelopment" xlink:label="loc_lly_AcquiredInProcessResearchAndDevelopment_E8EE54FA63EB4E1CAD6F325BECF0AEF4" xlink:type="locator" />
    <definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_B41C345C58DF72A23295325BECEA33D8" xlink:to="loc_lly_AcquiredInProcessResearchAndDevelopment_E8EE54FA63EB4E1CAD6F325BECF0AEF4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_RestructuringSettlementAndImpairmentProvisions" xlink:label="loc_us-gaap_RestructuringSettlementAndImpairmentProvisions_D1846A1AB96CD9A86DFE325BECF00728" xlink:type="locator" />
    <definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_B41C345C58DF72A23295325BECEA33D8" xlink:to="loc_us-gaap_RestructuringSettlementAndImpairmentProvisions_D1846A1AB96CD9A86DFE325BECF00728" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ForeignCurrencyTransactionGainLossRealized" xlink:label="loc_us-gaap_ForeignCurrencyTransactionGainLossRealized_47120B493AFC7A7B4454325BECF077FD" xlink:type="locator" />
    <definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_B41C345C58DF72A23295325BECEA33D8" xlink:to="loc_us-gaap_ForeignCurrencyTransactionGainLossRealized_47120B493AFC7A7B4454325BECF077FD" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_NonoperatingIncomeExpense" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_64164C67832354A9E31E325BECF08A24" xlink:type="locator" />
    <definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_B41C345C58DF72A23295325BECEA33D8" xlink:to="loc_us-gaap_NonoperatingIncomeExpense_64164C67832354A9E31E325BECF08A24" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AmortizationOfIntangibleAssets" xlink:label="loc_us-gaap_AmortizationOfIntangibleAssets_7D1F914DB9D2F2958908325BECF1D4C6" xlink:type="locator" />
    <definitionArc order="9" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_B41C345C58DF72A23295325BECEA33D8" xlink:to="loc_us-gaap_AmortizationOfIntangibleAssets_7D1F914DB9D2F2958908325BECF1D4C6" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CostOfGoodsSold" xlink:label="loc_us-gaap_CostOfGoodsSold_BF041E4442D8EA190756325BECF1F7A1" xlink:type="locator" />
    <definitionArc order="10" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_B41C345C58DF72A23295325BECEA33D8" xlink:to="loc_us-gaap_CostOfGoodsSold_BF041E4442D8EA190756325BECF1F7A1" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SellingGeneralAndAdministrativeExpense" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpense_E995B6FD7D3636C1E2DB325BECF1BDA9" xlink:type="locator" />
    <definitionArc order="11" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_B41C345C58DF72A23295325BECEA33D8" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpense_E995B6FD7D3636C1E2DB325BECF1BDA9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_GainsLossesOnExtinguishmentOfDebt" xlink:label="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_CCBD980583BF0E734D77325BECF18BAA" xlink:type="locator" />
    <definitionArc order="12" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_B41C345C58DF72A23295325BECEA33D8" xlink:to="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_CCBD980583BF0E734D77325BECF18BAA" xlink:type="arc" />
  </definitionLink>
  <definitionLink xlink:role="http://www.lilly.com/role/SegmentInformationTables" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SegmentReportingInformationLineItems" xlink:label="loc_us-gaap_SegmentReportingInformationLineItems_CC2569EAD8F510BD4AB5A5DAF5C09C40" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable" xlink:label="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_CF420B264B9783C324FEA5DAF5C0C5DB" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_CC2569EAD8F510BD4AB5A5DAF5C09C40" xlink:to="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_CF420B264B9783C324FEA5DAF5C0C5DB" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ConsolidationItemsAxis" xlink:label="loc_us-gaap_ConsolidationItemsAxis_7B8A50497483B36A8437A5DAF5C0DDAE" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_CF420B264B9783C324FEA5DAF5C0C5DB" xlink:to="loc_us-gaap_ConsolidationItemsAxis_7B8A50497483B36A8437A5DAF5C0DDAE" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ConsolidationItemsDomain" xlink:label="loc_us-gaap_ConsolidationItemsDomain_347885557BEF506EE134A5DAF5C0F9DF_default" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ConsolidationItemsAxis_7B8A50497483B36A8437A5DAF5C0DDAE" xlink:to="loc_us-gaap_ConsolidationItemsDomain_347885557BEF506EE134A5DAF5C0F9DF_default" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ConsolidationItemsDomain" xlink:label="loc_us-gaap_ConsolidationItemsDomain_347885557BEF506EE134A5DAF5C0F9DF" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ConsolidationItemsAxis_7B8A50497483B36A8437A5DAF5C0DDAE" xlink:to="loc_us-gaap_ConsolidationItemsDomain_347885557BEF506EE134A5DAF5C0F9DF" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_StatementBusinessSegmentsAxis" xlink:label="loc_us-gaap_StatementBusinessSegmentsAxis_5840F55D56BF1E0FC899A5DAF5C00AB5" xlink:type="locator" />
    <definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_CF420B264B9783C324FEA5DAF5C0C5DB" xlink:to="loc_us-gaap_StatementBusinessSegmentsAxis_5840F55D56BF1E0FC899A5DAF5C00AB5" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SegmentDomain" xlink:label="loc_us-gaap_SegmentDomain_130A5B6DC742CBB0972CA5DAF5C00CCD_default" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_5840F55D56BF1E0FC899A5DAF5C00AB5" xlink:to="loc_us-gaap_SegmentDomain_130A5B6DC742CBB0972CA5DAF5C00CCD_default" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SegmentDomain" xlink:label="loc_us-gaap_SegmentDomain_130A5B6DC742CBB0972CA5DAF5C00CCD" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_5840F55D56BF1E0FC899A5DAF5C00AB5" xlink:to="loc_us-gaap_SegmentDomain_130A5B6DC742CBB0972CA5DAF5C00CCD" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SubsegmentsAxis" xlink:label="loc_us-gaap_SubsegmentsAxis_9A1B00DB79D945D63B40A5DAF5C0A28C" xlink:type="locator" />
    <definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_CF420B264B9783C324FEA5DAF5C0C5DB" xlink:to="loc_us-gaap_SubsegmentsAxis_9A1B00DB79D945D63B40A5DAF5C0A28C" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SubsegmentsDomain" xlink:label="loc_us-gaap_SubsegmentsDomain_13EAF5B3E80ED0FD1105A5DAF5C04982_default" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_SubsegmentsAxis_9A1B00DB79D945D63B40A5DAF5C0A28C" xlink:to="loc_us-gaap_SubsegmentsDomain_13EAF5B3E80ED0FD1105A5DAF5C04982_default" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SubsegmentsDomain" xlink:label="loc_us-gaap_SubsegmentsDomain_13EAF5B3E80ED0FD1105A5DAF5C04982" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_SubsegmentsAxis_9A1B00DB79D945D63B40A5DAF5C0A28C" xlink:to="loc_us-gaap_SubsegmentsDomain_13EAF5B3E80ED0FD1105A5DAF5C04982" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SubsegmentsConsolidationItemsAxis" xlink:label="loc_us-gaap_SubsegmentsConsolidationItemsAxis_77DA7264ACA7F2B65781A5DAF5C09DD8" xlink:type="locator" />
    <definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_CF420B264B9783C324FEA5DAF5C0C5DB" xlink:to="loc_us-gaap_SubsegmentsConsolidationItemsAxis_77DA7264ACA7F2B65781A5DAF5C09DD8" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SubsegmentsConsolidationItemsDomain" xlink:label="loc_us-gaap_SubsegmentsConsolidationItemsDomain_5B0BD44D0DA75285F0F7A5DAF5C02E1A_default" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_SubsegmentsConsolidationItemsAxis_77DA7264ACA7F2B65781A5DAF5C09DD8" xlink:to="loc_us-gaap_SubsegmentsConsolidationItemsDomain_5B0BD44D0DA75285F0F7A5DAF5C02E1A_default" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SubsegmentsConsolidationItemsDomain" xlink:label="loc_us-gaap_SubsegmentsConsolidationItemsDomain_5B0BD44D0DA75285F0F7A5DAF5C02E1A" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_SubsegmentsConsolidationItemsAxis_77DA7264ACA7F2B65781A5DAF5C09DD8" xlink:to="loc_us-gaap_SubsegmentsConsolidationItemsDomain_5B0BD44D0DA75285F0F7A5DAF5C02E1A" xlink:type="arc" />
  </definitionLink>
  <definitionLink xlink:role="http://www.lilly.com/role/ShareholdersEquity" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_EquityClassOfTreasuryStockLineItems" xlink:label="loc_us-gaap_EquityClassOfTreasuryStockLineItems_F2B8317495BF27F77BCFA5DAF4F3874D" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ClassOfTreasuryStockTable" xlink:label="loc_us-gaap_ClassOfTreasuryStockTable_7DBD0C735A0C8EE74FFAA5DAF4F3FF65" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_EquityClassOfTreasuryStockLineItems_F2B8317495BF27F77BCFA5DAF4F3874D" xlink:to="loc_us-gaap_ClassOfTreasuryStockTable_7DBD0C735A0C8EE74FFAA5DAF4F3FF65" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ShareRepurchaseProgramAxis" xlink:label="loc_us-gaap_ShareRepurchaseProgramAxis_9F9D870E6168490578E3A5DAF4F34B0E" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ClassOfTreasuryStockTable_7DBD0C735A0C8EE74FFAA5DAF4F3FF65" xlink:to="loc_us-gaap_ShareRepurchaseProgramAxis_9F9D870E6168490578E3A5DAF4F34B0E" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ShareRepurchaseProgramDomain" xlink:label="loc_us-gaap_ShareRepurchaseProgramDomain_07AD3B43A37A4F7FC8DFA5DAF4F3AE01_default" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ShareRepurchaseProgramAxis_9F9D870E6168490578E3A5DAF4F34B0E" xlink:to="loc_us-gaap_ShareRepurchaseProgramDomain_07AD3B43A37A4F7FC8DFA5DAF4F3AE01_default" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ShareRepurchaseProgramDomain" xlink:label="loc_us-gaap_ShareRepurchaseProgramDomain_07AD3B43A37A4F7FC8DFA5DAF4F3AE01" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ShareRepurchaseProgramAxis_9F9D870E6168490578E3A5DAF4F34B0E" xlink:to="loc_us-gaap_ShareRepurchaseProgramDomain_07AD3B43A37A4F7FC8DFA5DAF4F3AE01" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_StockholdersEquityNoteDisclosureTextBlock" xlink:label="loc_us-gaap_StockholdersEquityNoteDisclosureTextBlock_49350AC9B8513AEC78EAA5DAF4F31CCC" xlink:type="locator" />
    <definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityClassOfTreasuryStockLineItems_F2B8317495BF27F77BCFA5DAF4F3874D" xlink:to="loc_us-gaap_StockholdersEquityNoteDisclosureTextBlock_49350AC9B8513AEC78EAA5DAF4F31CCC" xlink:type="arc" />
  </definitionLink>
  <definitionLink xlink:role="http://www.lilly.com/role/ShareholdersEquityDetails" xlink:type="extended" />
</linkbase>
