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United States securities and exchange commission logo November 1, 2023 Anat Ashkenazi Executive Vice President and Chief Financial Officer Eli Lilly and Company Lilly Corporate Center Indianapolis, IN 46285 Re: Eli Lilly and Company Form 10-K for the fiscal year ended December 31, 2022 Response dated October 26, 2023 File No. 001-06351 Dear Anat Ashkenazi: We have reviewed your October 26, 2023 response to our comment letter and have the following comments. Please respond to this letter within ten business days by providing the requested information or advise us as soon as possible when you will respond. If you do not believe a comment applies to your facts and circumstances, please tell us why in your response. After reviewing your response to this letter, we may have additional comments. Unless we note otherwise, any references to prior comments are to comments in our September 29, 2023 letter. Response dated October 26, 2023 Management's Discussion and Analysis of Results of Operations and Financial Condition, page 37 1. We note your response to prior comment 1 and re-issue it in part. Please expand your disclosure to address how your reputation or brand could be affected by climate change and the potential response from investors, lenders, and customers. 2. We note your response to prior comment 2 stating that you did not experience any material impacts from severe weather-related events and re-issue it in part. Please quantify all weather-related damages to your property or operations for each of the years ended December 31, 2022, 2021, and 2020. Anat Ashkenazi FirstName LastNameAnat Ashkenazi Eli Lilly and Company Comapany 1, November NameEli 2023 Lilly and Company November Page 2 1, 2023 Page 2 FirstName LastName Please contact Anuja A. Majmudar, Attorney-Adviser, at (202) 551-3844 or Karina Dorin, Attorney-Adviser, at (202) 551-3763 with any questions. Sincerely, Division of Corporation Finance Office of Life Sciences cc: Donald A. Zakrowski, Senior VP Finance & CAO