View Filing Data

Other Comprehensive Income (Loss), Net of Tax, Portion Attributable to Parent

^[1]

198.7

316.0

Comprehensive income

87.9

$ 756.1

209.7

Other Comprehensive Income (Loss), Net of Tax, Portion Attributable to Noncontrolling Interest

$ (11.0)

[1]

(1) Other comprehensive income (loss) for the three months ended March 31, 2017 consisted of $209.7 million of other comprehensive income attributable to controlling interest and $(11.0) million of other comprehensive income (loss) attributable to non-controlling interest. Other comprehensive income (loss) for the three months ended March 31, 2016 attributable to non-controlling interest is immaterial.

Consolidated Condensed Balance Sheets - USD ($) $ in Millions	Mar. 31, 2017	Dec. 31, 2016
Current Assets
Cash and cash equivalents	$ 2,616.9	$ 4,582.1
Short-term investments	888.7	1,456.5
Accounts receivable, net of allowances of $41.8 (2017) and $40.3 (2016)	4,017.2	4,029.4
Other receivables	596.7	736.9
Inventories	4,035.1	3,561.9
Prepaid expenses and other	821.6	734.6
Total current assets	12,976.2	15,101.4
Other Assets
Investments	5,297.7	5,207.5
Goodwill	4,188.0	3,972.7
Other intangibles, net	4,716.7	4,357.9
Sundry	2,020.2	1,913.8
Total other assets	16,222.6	15,451.9
Property and Equipment
Land, buildings, equipment, and construction in progress	17,136.6	16,777.6
Accumulated depreciation	(8,711.1)	(8,525.0)
Property and equipment, net	8,425.5	8,252.6
Total assets	37,624.3	38,805.9
Current Liabilities
Short-term borrowings and current maturities of long-term debt	2,609.3	1,937.4
Accounts payable	1,220.1	1,349.3
Employee compensation	566.5	896.9
Sales rebates and discounts	3,697.5	3,914.9
Dividends payable	0.0	548.1
Income taxes payable	122.0	119.1
Other current liabilities	2,232.6	2,220.9
Total current liabilities	10,448.0	10,986.6
Other Liabilities
Long-term debt	7,637.5	8,367.8
Accrued retirement benefits	2,455.7	2,453.9
Long-term income taxes payable	697.2	688.9
Other noncurrent liabilities	2,282.2	2,228.2
Total other liabilities	13,072.6	13,738.8
Eli Lilly and Company Shareholders' Equity
Common stock	690.0	688.5
Additional paid-in capital	5,617.6	5,640.6
Retained earnings	15,876.7	16,046.3
Employee benefit trust	(3,013.2)	(3,013.2)
Accumulated other comprehensive loss	(5,064.3)	(5,274.0)
Cost of common stock in treasury	(75.8)	(80.5)
Total Eli Lilly and Company shareholders' equity	14,031.0	14,007.7
Noncontrolling interests	72.7	72.8
Total equity	14,103.7	14,080.5
Total liabilities and equity	$ 37,624.3	$ 38,805.9

Consolidated Condensed Balance Sheets (Parenthetical) - USD ($) $ in Millions	Mar. 31, 2017	Dec. 31, 2016
Allowances for doubtful accounts	$ 41.8	$ 40.3

Consolidated Condensed Statements of Cash Flows - USD ($) $ in Millions	3 Months Ended
	Mar. 31, 2017	Mar. 31, 2016
Cash Flows from Operating Activities
Net income (loss)	$ (110.8)	$ 440.1
Adjustments to Reconcile Net Income (Loss) to Cash Flows from Operating Activities:
Depreciation and amortization	386.9	385.5
Change in deferred income taxes	128.8	30.6
Stock-based compensation expense	69.3	62.0
Acquired in-process research and development	857.6	0.0
Other changes in operating assets and liabilities, net of acquisitions	(995.0)	(1,382.9)
Other non-cash operating activities, net	3.1	245.6
Net Cash Provided by (Used for) Operating Activities	339.9	(219.1)
Cash Flows from Investing Activities
Net purchases of property and equipment	(169.0)	(154.3)
Proceeds from sales and maturities of short-term investments	1,168.4	521.6
Purchases of short-term investments	(289.4)	(98.4)
Proceeds from sales of noncurrent investments	528.0	338.9
Purchases of noncurrent investments	(945.9)	(716.7)
Cash paid for acquisitions, net of cash acquired	(882.1)	0.0
Purchase of in-process research and development	(831.8)	0.0
Other investing activities, net	(7.8)	(36.5)
Net Cash Used for Investing Activities	(1,429.6)	(145.4)
Cash Flows from Financing Activities
Dividends paid	(547.4)	(538.3)
Net change in short-term borrowings	497.5	(1.1)
Repayments of long-term debt	(630.2)	0.0
Purchases of common stock	0.0	(300.1)
Other financing activities, net	(195.6)	(84.7)
Net Cash Used for Financing Activities	(875.7)	(924.2)
Effect of exchange rate changes on cash and cash equivalents	0.2	(70.1)
Net decrease in cash and cash equivalents	(1,965.2)	(1,358.8)
Cash and cash equivalents at January 1	4,582.1	3,666.4
Cash and Cash Equivalents at March 31	$ 2,616.9	$ 2,307.6

Basis of Presentation	3 Months Ended
Basis of Presentation	Mar. 31, 2017
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Basis of Presentation [Text Block]	Note 1: Basis of Presentation We have prepared the accompanying unaudited consolidated condensed financial statements in accordance with the requirements of Form 10-Q and, therefore, they do not include all information and footnotes necessary for a fair presentation of financial position, results of operations, and cash flows in conformity with accounting principles generally accepted in the United States (GAAP). In our opinion, the financial statements reflect all adjustments (including those that are normal and recurring) that are necessary for a fair presentation of the results of operations for the periods shown. In preparing financial statements in conformity with GAAP, we must make estimates and assumptions that affect the reported amounts of assets, liabilities, revenues, expenses, and related disclosures at the date of the financial statements and during the reporting period. Actual results could differ from those estimates. The information included in this Quarterly Report on Form 10-Q should be read in conjunction with our consolidated financial statements and accompanying notes included in our Annual Report on Form 10-K for the year ended December 31, 2016. We issue our financial statements by filing with the Securities and Exchange Commission and have evaluated subsequent events up to the time of the filing. Certain reclassifications have been made to prior periods in the consolidated condensed financial statements and accompanying notes to conform with the current presentation. These reclassifications include $107.8 million that decreased net cash used for operating activities and increased net cash used for financing activities on the consolidated condensed statements of cash flows as a result of our adoption in the fourth quarter of 2016 of Accounting Standards Update 2016-09, Compensation - Stock Compensation: Improvements to Employee Share-Based Payment Accounting as discussed in our Annual Report on Form 10-K for the year ended December 31, 2016. All per-share amounts, unless otherwise noted in the footnotes, are presented on a diluted basis, that is, based on the weighted-average number of outstanding common shares plus the effect of incremental shares from our stock-based compensation programs.

Implementation of New Financial Accounting Pronouncements

3 Months Ended

Mar. 31, 2017

New Accounting Pronouncements and Changes in Accounting Principles [Abstract]

Accounting Changes and Error Corrections [Text Block]

Note 2: Implementation of New Financial Accounting Pronouncements

The following table provides a brief description of accounting standards that have not yet been adopted and could have a material effect on our financial statements:



Standard	Description	Effective Date	Effect on the financial statements or other significant matters
Accounting Standards Update 2014-09 and various other related updates, Revenue from Contracts with Customers	This standard will replace existing revenue recognition standards and will require entities to recognize revenues to depict the transfer of promised goods or services to customers in an amount that reflects the consideration to which the entity expects to be entitled in exchange for those goods or services. An entity can apply the new revenue standard retrospectively to each prior reporting period presented or with the cumulative effect of initially applying the standard recognized at the date of initial application in retained earnings. We currently plan to use the latter approach.	This standard is effective January 1, 2018, and we will adopt on that date.	We are in the process of evaluating the impact of the adoption of the standard. We have identified two revenue streams from our contracts with customers: 1) product sales and 2) licensing arrangements. While our evaluation of our contracts for product sales is not yet complete, based upon the results of our work to date we currently do not expect the application of the new standard to these contracts to have a material impact to our consolidated financial statements either at initial implementation or on an ongoing basis. We are in the process of reviewing arrangements in which we have licensed or sold intellectual property and are not yet able to estimate the anticipated impact to our consolidated financial statements from the application of the new standard to our arrangements as we continue to interpret and apply the principles in the new standard to our arrangements.
Accounting Standards Update 2016-01, Financial Instruments - Overall: Recognition and Measurement of Financial Assets and Financial Liabilities	This standard will require entities to recognize changes in the fair value of equity investments with readily determinable fair values in net income (except for investments accounted for under the equity method of accounting or those that result in consolidation of the investee). An entity should apply the new standard through a cumulative effect adjustment to retained earnings as of the beginning of the fiscal year of adoption.	This standard is effective January 1, 2018. Early adoption of the majority of the amendments in this standard is not permitted, however, early application of certain amendments is permitted. We intend to fully adopt this standard on January 1, 2018.	We are unable to estimate the impact of adopting this standard as the significance of the impact will depend upon our equity investments as of the date of adoption.



Standard	Description	Effective Date	Effect on the financial statements or other significant matters
Accounting Standards Update 2016-02, Leases	This standard was issued to increase transparency and comparability among organizations by recognizing lease assets and lease liabilities, including leases classified as operating leases under current GAAP, on the balance sheet and requiring additional disclosures about leasing arrangements. This standard requires a modified retrospective approach to adoption.	This standard is effective January 1, 2019, with early adoption permitted. We intend to adopt this standard on January 1, 2019.	We are in the process of determining the potential impact on our consolidated financial statements.
Accounting Standards Update 2016-16, Income Taxes: Intra-Entity Transfers of Assets Other Than Inventory	This standard will require entities to recognize the income tax consequences of intra-entity transfers of assets other than inventory at the time of transfer. This standard requires a modified retrospective approach to adoption.	This standard is effective January 1, 2018, and we will adopt on that date.	We are continuing to assess the potential impact of this standard on our consolidated financial statements and currently estimate that the cumulative effect of initially applying the standard would result in an increase to deferred tax assets and the opening balance of retained earnings of approximately $2 billion on January 1, 2018. This estimate is subject to change based upon intra-entity transfers of assets other than inventory over the remainder of 2017 and ongoing assessments of the future deductibility and realizability of the deferred tax assets that would result from implementation.
Accounting Standards Update 2017-07, Compensation-Retirement Benefits: Improving the Presentation of Net Periodic Pension Cost and Net Periodic Postretirement Benefit Cost	This standard was issued to improve the transparency and comparability among organizations by requiring entities to separate their net periodic pension cost and net periodic postretirement benefit cost into a service cost component and other components. Currently, the costs of the other components along with the service cost component are classified based upon the function of the employee. This standard will require entities to classify the service cost component in the same financial statement line item or items as other compensation costs arising from services rendered by pertinent employees. The other components of net benefit cost will be presented separately from the line items that include the service cost component. When applicable, the service cost component will be the only component eligible for capitalization. An entity should apply the new standard retrospectively for the classification of the service cost and other components and prospectively for the capitalization of the service cost component.	This standard is effective January 1, 2018, with early adoption permitted. We intend to adopt this standard on January 1, 2018.	Upon adoption of this standard, pension and postretirement benefit cost components other than service costs will be presented in other–net, (income) expense. We do not expect the application of the new standard to have a material impact on consolidated net income either at initial implementation or on an ongoing basis.

The entire disclosure of changes in accounting principles, including adoption of new accounting pronouncements, that describes the new methods, amount and effects on financial statement line items.

Reference 1: http://www.xbrl.org/2003/role/presentationRef
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-Glossary Change in Accounting Principle
-URI http://asc.fasb.org/extlink&oid=6507316

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Acquisitions [Text Block]

Acquisitions

3 Months Ended

Mar. 31, 2017

Business Combinations [Abstract]

Note 3: Acquisitions

On January 3, 2017, we completed the acquisition of Boehringer Ingelheim Vetmedica, Inc.'s United States (U.S.) feline, canine, and rabies vaccine portfolio and other related assets (BIVIVP). This transaction, as further discussed in this note below in Acquisition of a Business, was accounted for as a business combination under the acquisition method of accounting. Under this method, the assets acquired and liabilities assumed were recorded at their respective fair values as of the acquisition date in our consolidated financial statements. The determination of estimated fair value required management to make significant estimates and assumptions. The excess of the purchase price over the fair value of the acquired net assets, where applicable, has been recorded as goodwill. The results of operations of this acquisition are included in our consolidated condensed financial statements from the date of acquisition.

In addition to the acquisition of BIVIVP, we also acquired an asset in development in the three months ended March 31, 2017, which is further discussed in this note below in Asset Acquisition. Upon acquisition, the acquired in-process research and development (IPR&D) charge of $857.6 million related to this product was immediately written off as an expense because the product had no alternative future use. There were no acquired IPR&D charges for the three months ended March 31, 2016.

Acquisition of a Business

Boehringer Ingelheim Vetmedica, Inc. Vaccine Portfolio Acquisition

Overview of Transaction

We acquired BIVIVP in an all-cash transaction for $882.1 million. Under the terms of the agreement, we acquired a manufacturing and research and development site, a U.S. vaccine portfolio including vaccines used for the treatment of bordetella, Lyme disease, rabies, and parvovirus, among others, as well as several pipeline assets. The accounting impact of this acquisition and the results of the operations are included in our consolidated condensed financial statements beginning on January 3, 2017.

Assets Acquired and Liabilities Assumed

Our access to BIVIVP information was limited prior to the acquisition. As a consequence, we are in the process of determining the fair values and tax bases of a significant portion of the assets acquired and liabilities assumed, including the identification and valuation of intangible assets, inventory, property and equipment, accrued expenses, and tax exposures. The final determination of these amounts will be completed as soon as possible but no later than one year from the acquisition date. The final determination may result in asset and liability fair values and tax bases that differ from, and require changes to, the preliminary amounts recognized.

The following table summarizes the preliminary amounts recognized for assets acquired and liabilities assumed as of the acquisition date:



Estimated Fair Value at January 3, 2017
Inventories	$	105.2
Acquired in-process research and development	33.0
Marketed products ⁽¹⁾	404.0
Property and equipment	156.2
Other assets and liabilities - net	(0.7		)
Total identifiable net assets	697.7
Goodwill ⁽²⁾	184.4
Total consideration transferred - net of cash acquired	$	882.1

⁽¹⁾ These intangible assets, which are being amortized to cost of sales on a straight-line basis over their estimated useful lives, were expected to have a weighted average useful life of 10 years.

⁽²⁾ The goodwill recognized from this acquisition is attributable primarily to expected synergies from combining the operations of BIVIVP with our legacy animal health business, future unidentified projects and products, and the assembled workforce of BIVIVP. We anticipate that the goodwill associated with this acquisition will be deductible for tax purposes.

Our consolidated condensed statement of operations for the three months ended March 31, 2017 includes BIVIVP revenue of $40.8 million. BIVIVP has been partially integrated into our animal health products segment and as a result of these integration efforts, certain parts of the animal health business were operating on a combined basis, and we could not distinguish the operations between BIVIVP and our legacy animal health products business.

Asset Acquisition

The following table and narrative summarizes our asset acquisition during the three months ended March 31, 2017. There was no asset acquisition which resulted in acquired IPR&D expense during the three months ended March 31, 2016.



Counterparty	Compound(s) or Therapy	Acquisition Month	Phase of Development ⁽¹⁾	Acquired IPR&D Expense
CoLucid Pharmaceuticals, Inc. (CoLucid)	Oral therapy for the acute treatment of migraine - lasmiditan	March 2017	Phase III	$	857.6

⁽¹⁾ The phase of development presented is as of the date of the arrangement.

In March 2017, we acquired CoLucid, including its Phase III molecule, lasmiditan. Under the terms of the agreement, we acquired all shares of CoLucid for a cash purchase price of $831.8 million, net of cash acquired, plus net accrued liabilities assumed of $25.8 million. Substantially all of the value of CoLucid is related to lasmiditan, its only significant asset. The acquired IPR&D expense is not tax deductible.

The entire disclosure for a business combination (or series of individually immaterial business combinations) completed during the period, including background, timing, and recognized assets and liabilities. The disclosure may include leverage buyout transactions (as applicable).

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Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]

Collaborations and Other Arrangements

3 Months Ended

Mar. 31, 2017

Collaborations [Text Block]

Note 4: Collaborations and Other Arrangements

We often enter into collaborative and other similar arrangements to develop and commercialize drug candidates. Collaborative activities may include research and development, marketing and selling (including promotional activities and physician detailing), manufacturing, and distribution. These arrangements often require milestone and royalty or profit-share payments, contingent upon the occurrence of certain future events linked to the success of the asset in development, as well as expense reimbursements or payments to the collaboration partner. Elements within a collaboration are separated into individual units of accounting if they have standalone value from other elements within the arrangement. In these situations, the arrangement consideration is allocated to the elements on a relative selling price basis. Revenues related to products we sell pursuant to these arrangements are included in net product revenues, while other sources of revenue (e.g., royalties and profit-sharing due from our partner) are included in collaboration and other revenue.

The following table summarizes our collaboration and other revenue, which is included in revenue in the consolidated condensed statements of operations:



	Three Months Ended March 31,
	2017		2016
Collaboration and other revenue	$	240.4	$	182.3

The following table summarizes our aggregate amount of marketing, selling, and administrative expense associated with our commission and profit-sharing obligations for the collaborations and other arrangements described above:



	Three Months Ended March 31,
	2017		2016
Marketing, selling, and administrative	$	46.7	$	49.0

Operating expenses for costs incurred pursuant to these arrangements are reported in their respective expense line item, net of any payments due to or reimbursements due from our collaboration partners, with such reimbursements being recognized at the time the party becomes obligated to pay. Each collaboration is unique in nature, and our more significant arrangements are discussed below.

Boehringer Ingelheim Diabetes Collaboration

We and Boehringer Ingelheim have a global agreement to jointly develop and commercialize a portfolio of diabetes compounds. Currently, included in the collaboration are Boehringer Ingelheim’s oral diabetes products: Trajenta^®, Jentadueto^®, Jardiance^®, Glyxambi^®, and Synjardy^®, as well as our basal insulin: Basaglar^®.

The table below summarizes significant regulatory and commercialization events and milestones (received) paid for the compounds included in this collaboration:



	Product Status			Milestones (Deferred) Capitalized ⁽¹⁾
Product Family	U.S.	Europe	Japan	Year	Amount
Trajenta ⁽²⁾	Launched 2011	Launched 2011	Launched 2011	2017	$	—
				2016	—
				Cumulative ⁽⁴⁾	446.4
Jardiance ⁽³⁾	Launched 2014	Launched 2014	Launched 2015	2017	—
				2016	—
				Cumulative ⁽⁴⁾	299.5
Basaglar	Launched 2016	Launched 2015	Launched 2015	2017	—
				2016	(187.5		)
				Cumulative ⁽⁴⁾	(250.0		)

⁽¹⁾ In connection with the regulatory approvals of Basaglar in the U.S., Europe, and Japan, milestone payments received were recorded as deferred revenue and are being amortized through the term of the collaboration (2029) to collaboration and other revenue. In connection with the regulatory approvals of Trajenta and Jardiance, milestone payments made were capitalized as intangible assets and are being amortized to cost of sales.

⁽²⁾ Jentadueto is included in the Trajenta family of product results.

⁽³⁾ Glyxambi and Synjardyare included in the Jardiance family of product results.

⁽⁴⁾ The cumulative amount represents the total initial amounts that were (deferred) or capitalized from the start of this collaboration through the end of the reporting period.

In the most significant markets, we and Boehringer Ingelheim share equally the ongoing development costs, commercialization costs and agreed upon gross margin for any product resulting from the collaboration. We record our portion of the gross margin associated with Boehringer Ingelheim's compounds as collaboration and other revenue. We record our sales of Basaglar to third parties as net product revenue with the payments made to Boehringer Ingelheim for their portion of the gross margin recorded as cost of sales. For all compounds under this collaboration, we record our portion of the development and commercialization costs as research and development expense and marketing, selling, and administrative expense, respectively. Each company is entitled to potential performance payments depending on the sales of the molecules it contributes to the collaboration. These performance payments result in the owner of the molecule retaining a greater share of the agreed upon gross margin of that product.

The following table summarizes our collaboration and other revenue recognized with respect to the Trajenta and Jardiance families of products and net product revenue recognized with respect to Basaglar:



	Three Months Ended March 31,
	2017		2016
Trajenta	$	113.0	$	94.4
Jardiance	74.0		38.2
Basaglar	46.0		10.9

Erbitux^®

We have several collaborations with respect to Erbitux. The most significant collaborations are or, where applicable, were in Japan, and prior to the transfer of commercialization rights in the fourth quarter of 2015, the U.S. and Canada (Bristol-Myers Squibb Company); and worldwide except the U.S. and Canada (Merck KGaA). Certain rights to Erbitux outside the U.S. and Canada (collectively, North America) will remain with Merck KGaA (Merck) upon expiration of that agreement.

The following table summarizes our revenue recognized with respect to Erbitux:



	Three Months Ended March 31,
	2017		2016
Net product revenue	$	131.3	$	141.5
Collaboration and other revenue	23.1		26.6
Revenue	$	154.4	$	168.1

Bristol-Myers Squibb Company

Pursuant to commercial agreements with Bristol-Myers Squibb Company and E.R. Squibb (collectively, BMS), we had been co-developing Erbitux in North America with BMS exclusively. A separate agreement grants co-exclusive rights among Merck, BMS, and us in Japan and expires in 2032. On October 1, 2015, BMS transferred their commercialization rights to us with respect to Erbitux in North America pursuant to a modification of our existing arrangement, and we began selling Erbitux at that time. This modification did not affect our rights with respect to Erbitux in other jurisdictions. In connection with the modification of terms, we provide consideration to BMS based upon a tiered percentage of net sales of Erbitux in North America estimated to average 38 percent through September 2018. The transfer of the commercialization rights was accounted for as an acquisition of a business. The consideration to be paid to BMS was accounted for as contingent consideration liability. See Note 6 for discussion regarding the estimation of this liability.

Merck KGaA

A development and license agreement grants Merck exclusive rights to market Erbitux outside of North America until December 2018. A separate agreement grants co-exclusive rights among Merck, BMS, and us in Japan and expires in 2032. This agreement was amended in 2015 to grant Merck exclusive commercialization rights in Japan but did not result in any changes to our rights.

Merck manufactures Erbitux for supply in its territory as well as for Japan. We receive a royalty on the sales of Erbitux outside of North America, which is included in collaboration and other revenue as earned. Royalties due to third parties are recorded as a reduction of collaboration and other revenue, net of any royalty reimbursements due from third parties.

Effient^®

We are in a collaborative arrangement with Daiichi Sankyo Co., Ltd. (Daiichi Sankyo) to develop, market, and promote Effient. Marketing rights for major territories are shown below. We and Daiichi Sankyo each have exclusive marketing rights in certain other territories.



Territory	Marketing Rights	Selling Party
U.S.	Co-promotion	Lilly
Major European markets	Co-promotion	Pre-January 1, 2016, Lilly Post-January 1, 2016, Daiichi Sankyo
Japan	Exclusive	Daiichi Sankyo

Beginning January 1, 2016, while major European markets continue to be a co-promotion territory under the terms of our arrangement, Daiichi Sankyo exclusively promotes Effient in these markets. The economic results for the major European markets continue to be shared in the same proportion as they were previously.

The parties share approximately 50/50 in the profits, as well as in the costs of development and marketing in the co-promotion territories. A third party manufactures bulk product, and we continue to produce the finished product for our exclusive and co-promotion territories, including the major European markets.

We record net product revenue in our exclusive and co-promotion territories where we are the selling party. Profit-share payments due to Daiichi Sankyo for co-promotion countries where we are the selling party are recorded as marketing, selling, and administrative expenses. Beginning January 1, 2016, any profit-share payments due to us from Daiichi Sankyo for the major European markets are recorded as collaboration and other revenue. We also record our share of the expenses in these co-promotion territories as marketing, selling, and administrative expenses. In our exclusive territories, we pay Daiichi Sankyo a royalty specific to these territories. All royalties due to Daiichi Sankyo and the third-party manufacturer are recorded in cost of sales.

The following table summarizes our revenue recognized with respect to Effient:



	Three Months Ended March 31,
	2017		2016
Revenue	$	127.8	$	131.5

Olumiant^®

We have a worldwide license and collaboration agreement with Incyte Corporation (Incyte) which provides us the development and commercialization rights to its Janus tyrosine kinase inhibitor compound, now known as baricitinib (trade name Olumiant), and certain follow-on compounds, for the treatment of inflammatory and autoimmune diseases. Incyte has the right to receive tiered, double-digit royalty payments on future global sales with rates ranging up to 20 percent if the product is successfully commercialized. The agreement provides Incyte with options to co-develop these compounds on an indication-by-indication basis by funding 30 percent of the associated development costs from the initiation of a Phase IIb trial through regulatory approval in exchange for increased tiered royalties ranging up to percentages in the high twenties. Incyte exercised its option to co-develop Olumiant in rheumatoid arthritis and psoriatic arthritis in 2010 and 2017, respectively. The agreement calls for payments by us to Incyte associated with certain development, success-based regulatory, and sales-based milestones. In the first quarter of 2016, we incurred milestone-related expenses of $55.0 million in connection with regulatory submissions in the U.S. and Europe which were recorded as research and development expense. In the first quarter of 2017, we capitalized as an intangible asset a $65.0 million milestone in connection with the regulatory approval in Europe, which is being amortized to cost of sales over the term of the collaboration. As of March 31, 2017, Incyte is eligible to receive up to $295.0 million of additional payments from us contingent upon certain development and success-based regulatory milestones, of which $115.0 million relates to regulatory decisions for a first indication. Incyte is also eligible to receive up to $150.0 million of potential sales-based milestones.

Tanezumab

We have a collaboration agreement with Pfizer Inc. (Pfizer) to jointly develop and globally commercialize tanezumab for the treatment of osteoarthritis pain, chronic low back pain and cancer pain. Under the agreement, the companies share equally the ongoing development costs and, if successful, in gross margins and certain commercialization expenses. Following the U.S. Food and Drug Administration's (FDA's) decision in March 2015 to lift the partial clinical hold on tanezumab, certain Phase III trials resumed in July 2015. Upon the FDA's lifting of the partial clinical hold and the decision to continue the collaboration with Pfizer, we paid an upfront fee of $200.0 million, which was expensed as acquired IPR&D. As of March 31, 2017, Pfizer is eligible to receive up to $350.0 million in success-based regulatory milestones and up to $1.23 billion in a series of sales-based milestones, contingent upon the commercial success of tanezumab.

Lanabecestat

In September 2014, we entered into a collaboration agreement with AstraZeneca for the worldwide co-development and co-commercialization of AstraZeneca’s lanabecestat, an oral beta-secretase cleaving enzyme (BACE) inhibitor being investigated for the potential treatment of Alzheimer’s disease. We are responsible for leading development efforts, while AstraZeneca will be responsible for manufacturing efforts. If successful, both parties will take joint responsibility for commercialization. Under the agreement, both parties share equally in the ongoing development costs and, if successful, in gross margins and certain other costs associated with commercialization of the molecule. As a result of the molecule moving into Phase III testing in April 2016, we incurred a $100.0 million developmental milestone, which was recorded as research and development expense in the second quarter of 2016. As of March 31, 2017, AstraZeneca is eligible to receive up to $350.0 million of additional payments from us contingent upon the achievement of certain development and success-based regulatory milestones.

Asset Impairment, Restructuring, and Other Special Charges Asset Impairment, Restructuring, and Other Special Charges

3 Months Ended

Mar. 31, 2017

Restructuring Cost and Reserve [Line Items]

Restructuring and Related Activities Disclosure [Text Block]

Note 5: Asset Impairment, Restructuring, and Other Special Charges

The components of the charges included in asset impairment, restructuring, and other special charges in our consolidated condensed statements of operations are described below.



	Three Months Ended March 31,
	2017		2016
Severance:
Human pharmaceutical products	$	113.1	$	—
Animal health products	55.6		9.5
Total severance	168.7		9.5
Asset impairment and other special charges:
Animal health products	45.2		121.9
Total asset impairment, restructuring, and other special charges	$	213.9	$	131.4

Severance costs recognized during the three months ended March 31, 2017 incurred as a result of actions taken to reduce our cost structure, as well as the integration of Novartis Animal Health (Novartis AH). Severance costs recognized during the three months ended March 31, 2016 related primarily to our decision to close an animal health manufacturing plant in Ireland as well as the integration of Novartis AH. Substantially all of the severance costs incurred during the three months ended March 31, 2017 are expected to be paid in the next 12 months.

Asset impairment and other special charges recognized during the three months ended March 31, 2017 resulted primarily from integration costs of Novartis AH, as well as asset impairments due to site closures. Asset impairment and other special charges recognized during the three months ended March 31, 2016 resulted primarily from $87.2 million of asset impairment and other charges related to our decision to close an animal health manufacturing plant in Ireland. The manufacturing plant was written down to its estimated fair value, which was based primarily on recent sales of similar assets. The remaining asset impairment and other special charges recognized during the three months ended March 31, 2016 consisted of integration costs related to our acquisition of Novartis AH.

Financial Instruments

3 Months Ended

Mar. 31, 2017

Fair Value Disclosures [Abstract]

Financial Instruments [Text Block]

Note 6: Financial Instruments

Financial instruments that potentially subject us to credit risk consist principally of trade receivables and interest-bearing investments. Wholesale distributors of life-science products account for a substantial portion of our trade receivables; collateral is generally not required. The risk associated with this concentration is mitigated by our ongoing credit-review procedures and insurance. A large portion of our cash is held by a few major financial institutions. We monitor our exposures with these institutions and do not expect any of these institutions to fail to meet their obligations. Major financial institutions represent the largest component of our investments in corporate debt securities. In accordance with documented corporate risk-management policies, we monitor the amount of credit exposure to any one financial institution or corporate issuer. We are exposed to credit-related losses in the event of nonperformance by counterparties to risk-management instruments but do not expect any counterparties to fail to meet their obligations given their high credit ratings.

Our derivative activities are initiated within the guidelines of documented corporate risk-management policies and offset losses and gains on the assets, liabilities, and transactions being hedged. Management reviews the correlation and effectiveness of our derivatives on a quarterly basis.

For derivative instruments that are designated and qualify as fair value hedges, the derivative instrument is marked to market with gains and losses recognized currently in income to offset the respective losses and gains recognized on the underlying exposure. For derivative instruments that are designated and qualify as cash flow hedges, the effective portion of gains and losses is reported as a component of accumulated other comprehensive loss and reclassified into earnings in the same period the hedged transaction affects earnings. For derivative and non-derivative instruments that are designated and qualify as net investment hedges, the effective portion of foreign currency translation gains or losses due to spot rate fluctuations are reported as a component of accumulated other comprehensive loss. Hedge ineffectiveness is immediately recognized in earnings. Derivative contracts that are not designated as hedging instruments are recorded at fair value with the gain or loss recognized in current earnings during the period of change.

We may enter into foreign currency forward or option contracts to reduce the effect of fluctuating currency exchange rates (principally the euro, British pound, and the Japanese yen). Foreign currency derivatives used for hedging are put in place using the same or like currencies and duration as the underlying exposures. Forward and option contracts are principally used to manage exposures arising from subsidiary trade and loan payables and receivables denominated in foreign currencies. These contracts are recorded at fair value with the gain or loss recognized in other–net, (income) expense. We may enter into foreign currency forward and option contracts and currency swaps as fair value hedges of firm commitments. Forward contracts generally have maturities not exceeding 12 months. At March 31, 2017, we had outstanding foreign currency forward commitments to purchase 4.16 billion U.S. dollars and sell 3.89 billion euro, commitments to purchase 3.47 billion euro and sell 3.75 billion U.S. dollars, commitments to purchase 587.1 million U.S. dollars and sell 65.96 billion Japanese yen, commitments to purchase 269.3 million British pounds and sell 310.1 million euro, and commitments to purchase 224.4 million U.S. dollars and sell 180.6 million British pounds, which will all settle within 30 days.

Foreign currency exchange risk is also managed through the use of foreign currency debt and cross-currency interest rate swaps. Our foreign currency-denominated notes had carrying amounts of $3.42 billion and $3.34 billion as of March 31, 2017 and December 31, 2016, respectively, have been designated as, and are effective as, economic hedges of net investments in certain of our euro-denominated and Swiss franc-denominated foreign operations. Our cross-currency interest rate swaps that convert a portion of our U.S. dollar-denominated floating rate debt to euro-denominated floating rate debt have also been designated as, and are effective as, economic hedges of net investments in certain of our euro-denominated foreign operations.

In the normal course of business, our operations are exposed to fluctuations in interest rates which can vary the costs of financing, investing, and operating. We address a portion of these risks through a controlled program of risk management that includes the use of derivative financial instruments. The objective of controlling these risks is to limit the impact of fluctuations in interest rates on earnings. Our primary interest-rate risk exposure results from changes in short-term U.S. dollar interest rates. In an effort to manage interest-rate exposures, we strive to achieve an acceptable balance between fixed- and floating-rate debt and investment positions and may enter into interest rate swaps or collars to help maintain that balance.

Interest rate swaps or collars that convert our fixed-rate debt to a floating rate are designated as fair value hedges of the underlying instruments. Interest rate swaps or collars that convert floating-rate debt to a fixed rate are designated as cash flow hedges. Interest expense on the debt is adjusted to include the payments made or received under the swap agreements. Cash proceeds from or payments to counterparties resulting from the termination of interest rate swaps are classified as operating activities in our consolidated condensed statements of cash flows. At March 31, 2017, substantially all of our total long-term debt is at a fixed rate. We have converted approximately 25 percent of our long-term fixed-rate notes to floating rates through the use of interest rate swaps.

We may enter into forward contracts and designate them as cash flow hedges to limit the potential volatility of earnings and cash flow associated with forecasted sales of available-for-sale securities.

We also may enter into forward-starting interest rate swaps, which we designate as cash flow hedges, as part of any anticipated future debt issuances in order to reduce the risk of cash flow volatility from future changes in interest rates. Upon completion of a debt issuance and termination of the swap, the change in fair value of these instruments is recorded as part of other comprehensive income (loss) and is amortized to interest expense over the life of the underlying debt.

The Effect of Risk-Management Instruments on the Consolidated Condensed Statements of Operations

The following effects of risk-management instruments were recognized in other–net, (income) expense:



	Three Months Ended March 31,
	2017			2016
Fair value hedges:
Effect from hedged fixed-rate debt	$	(7.5	)	$	75.3
Effect from interest rate contracts	7.5			(75.3		)
Cash flow hedges:
Effective portion of losses on interest rate contracts reclassified from accumulated other comprehensive loss	3.8			3.7
Net losses on foreign currency exchange contracts not designated as hedging instruments	37.2			13.3

During the three months ended March 31, 2017 and 2016, net losses related to ineffectiveness, as well as net losses related to the portion of our risk-management hedging instruments, fair value hedges, and cash flow hedges that were excluded from the assessment of effectiveness, were not material.

The Effect of Risk-Management Instruments on Other Comprehensive Income (Loss)

The effective portion of risk-management instruments that was recognized in other comprehensive income (loss) is as follows:



	Three Months Ended March 31,
	2017			2016
Net investment hedges:
Foreign currency-denominated notes	$	(78.9	)	$	(77.8	)
Cross-currency interest rate swaps	(6.0		)	(1.2		)

During the next 12 months, we expect to reclassify from accumulated other comprehensive loss to earnings $15.1 million of pretax net losses on cash flow hedges of the variability in expected future interest payments on our floating rate debt.

Fair Value of Financial Instruments

The following tables summarize certain fair value information at March 31, 2017 and December 31, 2016 for assets and liabilities measured at fair value on a recurring basis, as well as the carrying amount and amortized cost of certain other investments:



					Fair Value Measurements Using
	Carrying Amount		Cost ⁽¹⁾		Quoted Prices in Active Markets for Identical Assets (Level 1)		Significant Other Observable Inputs (Level 2)		Significant Unobservable Inputs (Level 3)		Fair Value
March 31, 2017
Cash equivalents	$	990.5	$	990.5	$	916.8	$	73.7	$	—	$	990.5

Short-term investments:
U.S. government and agency securities	$	98.9	$	99.0	$	98.9	$	—	$	—	$	98.9
Corporate debt securities	784.7		784.4		—		784.7		—		784.7
Asset-backed securities	3.0		3.0		—		3.0		—		3.0
Other securities	2.1		2.1		—		2.1		—		2.1
Short-term investments	$	888.7

Noncurrent investments:
U.S. government and agency securities	$	359.1	$	363.2	$	359.1	$	—	$	—	$	359.1
Corporate debt securities	3,188.0		3,191.3		—		3,188.0		—		3,188.0
Mortgage-backed securities	171.5		173.6		—		171.5		—		171.5
Asset-backed securities	513.4		514.3		—		513.4		—		513.4
Other securities	167.1		83.3		—		—		167.1		167.1
Marketable equity securities	340.1		78.3		340.1		—		—		340.1
Cost and equity method investments ⁽²⁾	558.5
Noncurrent investments	$	5,297.7

December 31, 2016
Cash equivalents	$	2,986.8	$	2,986.8	$	2,699.4	$	287.4	$	—	$	2,986.8

Short-term investments:
U.S. government and agency securities	$	232.5	$	232.6	$	232.5	$	—	$	—	$	232.5
Corporate debt securities	1,219.2		1,219.1		—		1,219.2		—		1,219.2
Asset-backed securities	4.3		4.3		—		4.3		—		4.3
Other securities	0.5		0.5		—		0.5		—		0.5
Short-term investments	$	1,456.5

Noncurrent investments:
U.S. government and agency securities	$	318.9	$	323.8	$	318.9	$	—	$	—	$	318.9
Corporate debt securities	3,062.2		3,074.3		—		3,062.2		—		3,062.2
Mortgage-backed securities	183.1		185.4		—		183.1		—		183.1
Asset-backed securities	502.7		503.5		—		502.7		—		502.7
Other securities	153.7		77.6		—		—		153.7		153.7
Marketable equity securities	418.2		91.9		418.2		—		—		418.2
Cost and equity method investments ⁽²⁾	568.7
Noncurrent investments	$	5,207.5

⁽¹⁾ For available-for-sale debt securities, amounts disclosed represent the securities' amortized cost.

⁽²⁾ Fair value disclosures are not applicable for cost method and equity method investments.



				Fair Value Measurements Using
	Carrying Amount			Quoted Prices in Active Markets for Identical Assets (Level 1)		Significant Other Observable Inputs (Level 2)			Significant Unobservable Inputs (Level 3)		Fair Value
Short-term commercial paper borrowings
March 31, 2017	$	(1,799.7	)	$	—	$	(1,798.8	)	$	—	$	(1,798.8	)
December 31, 2016	(1,299.3		)	—		(1,299.3		)	—		(1,299.3		)
Long-term debt, including current portion
March 31, 2017	$	(8,447.1	)	$	—	$	(8,760.8	)	$	—	$	(8,760.8	)
December 31, 2016	(9,005.9		)	—		(9,419.1		)	—		(9,419.1		)



				Fair Value Measurements Using
	Carrying Amount			Quoted Prices in Active Markets for Identical Assets (Level 1)		Significant Other Observable Inputs (Level 2)			Significant Unobservable Inputs (Level 3)			Fair Value
March 31, 2017
Risk-management instruments:
Interest rate contracts designated as fair value hedges:
Other receivables	$	4.3		$	—	$	4.3		$	—		$	4.3
Sundry	28.9			—		28.9			—			28.9
Other current liabilities	(0.4		)	—		(0.4		)	—			(0.4		)
Other noncurrent liabilities	(1.0		)	—		(1.0		)	—			(1.0		)
Cross-currency interest rate contracts designated as net investment hedges:
Other receivables	5.3			—		5.3			—			5.3
Sundry	21.3			—		21.3			—			21.3
Foreign exchange contracts not designated as hedging instruments:
Other receivables	8.2			—		8.2			—			8.2
Other current liabilities	(49.5		)	—		(49.5		)	—			(49.5		)
Contingent consideration liabilities ⁽¹⁾:
Other current liabilities	(213.8		)	—		—			(213.8		)	(213.8		)
Other noncurrent liabilities	(189.4		)	—		—			(189.4		)	(189.4		)

December 31, 2016
Risk-management instruments:
Interest rate contracts designated as fair value hedges:
Other receivables	$	2.4		$	—	$	2.4		$	—		$	2.4
Sundry	37.0			—		37.0			—			37.0
Other noncurrent liabilities	(0.5		)	—		(0.5		)	—			(0.5		)
Cross-currency interest rate contracts designated as net investment hedges:
Sundry	31.4			—		31.4			—			31.4
Foreign exchange contracts not designated as hedging instruments:
Other receivables	31.8			—		31.8			—			31.8
Other current liabilities	(21.7		)	—		(21.7		)	—			(21.7		)
Contingent consideration liabilities ⁽¹⁾:
Other current liabilities	(215.9		)	—		—			(215.9		)	(215.9		)
Other noncurrent liabilities	(242.6		)	—		—			(242.6		)	(242.6		)

⁽¹⁾ Contingent consideration liabilities primarily relate to the Erbitux arrangement with BMS discussed in Note 4.

Risk-management instruments above are disclosed on a gross basis. There are various rights of setoff associated with certain of the risk-management instruments above that are subject to an enforceable master netting arrangement or similar agreements. Although various rights of setoff and master netting arrangements or similar agreements may exist with the individual counterparties to the risk-management instruments above, individually, these financial rights are not material.

We determine our Level 1 and Level 2 fair value measurements based on a market approach using quoted market values, significant other observable inputs for identical or comparable assets or liabilities, or discounted cash flow analyses. Level 3 fair value measurements for other investment securities are determined using unobservable inputs, including the investments' cost adjusted for impairments and price changes from orderly transactions. The fair values of cost and equity method investments are not readily available.

Contingent consideration liabilities primarily include contingent consideration related to Erbitux for which the fair value was estimated using a discounted cash flow analysis and Level 3 inputs, including projections representative of a market participant view for net sales in North America through September 2018 and an estimated discount rate. The amount to be paid is calculated as a tiered percentage of net sales (see Note 4) and will, therefore, vary directly with increases and decreases in net sales of Erbitux in North America. There is no cap on the amount that may be paid pursuant to this arrangement. The decrease in the fair value of the contingent consideration liabilities during the three months ended March 31, 2017 was due primarily to cash payments of $49.9 million related to Erbitux. The change in the fair value of the contingent consideration liabilities recognized in earnings during the three months ended March 31, 2017 and 2016 due to changes in time value of money was not material.

The table below summarizes the contractual maturities of our investments in debt securities measured at fair value as of March 31, 2017:



	Maturities by Period
	Total		Less Than 1 Year		1-5 Years		6-10 Years		More Than 10 Years
Fair value of debt securities	$	5,118.5	$	886.6	$	3,871.7	$	151.2	$	209.0

A summary of the fair value of available-for-sale securities in an unrealized gain or loss position and the amount of unrealized gains and losses (pretax) in accumulated other comprehensive loss follows:



	March 31, 2017		December 31, 2016
Unrealized gross gains	$	280.5	$	352.6
Unrealized gross losses	24.6		34.1
Fair value of securities in an unrealized gain position	2,173.7		1,869.7
Fair value of securities in an unrealized loss position	3,030.5		3,262.3

We periodically assess our investment securities for other-than-temporary impairment losses. Other-than-temporary impairment losses recognized during the three months ended March 31, 2016 were $25.7 million. There were no other-than-temporary impairment losses in the three months ended March 31, 2017.

For fixed-income securities, the amount of credit losses are determined by comparing the difference between the present value of future cash flows expected to be collected on these securities and the amortized cost. Factors considered in assessing credit losses include the position in the capital structure, vintage and amount of collateral, delinquency rates, current credit support, and geographic concentration.

For equity securities, factors considered in assessing other-than-temporary impairment losses include the length of time and the extent to which the fair value has been less than cost, the financial condition and near term prospects of the issuer, our intent and ability to retain the securities for a period of time sufficient to allow for recovery in fair value, and general market conditions and industry specific factors.

As of March 31, 2017, the securities in an unrealized loss position include primarily fixed-rate debt securities of varying maturities, which are sensitive to changes in the yield curve and other market conditions. Approximately 95 percent of the fixed-rate debt securities in a loss position are investment-grade debt securities. As of March 31, 2017, we do not intend to sell, and it is not more likely than not that we will be required to sell the securities in a loss position before the market values recover or the underlying cash flows have been received, and there is no indication of default on interest or principal payments for any of our debt securities.

Activity related to our investment portfolio, substantially all of which related to available-for-sale securities, was as follows:



	Three Months Ended March 31,
	2017		2016
Proceeds from sales	$	1,092.5	$	726.4
Realized gross gains on sales	51.7		1.8
Realized gross losses on sales	1.3		7.3

Realized gains and losses on sales of investments are computed based upon specific identification of the initial cost adjusted for any other-than-temporary declines in fair value that were recorded in earnings.

Accounts Receivable Factoring Arrangements

We have entered into accounts receivable factoring agreements with financial institutions to sell certain of our non-U.S. accounts receivable. These transactions are accounted for as sales and result in a reduction in accounts receivable because the agreements transfer effective control over and risk related to the receivables to the buyers. Our factoring agreements do not allow for recourse in the event of uncollectibility, and we do not retain interest in the underlying accounts receivable once sold. We derecognized $652.0 million and $661.6 million of accounts receivable as of March 31, 2017 and December 31, 2016, respectively, under these factoring arrangements. The cost of factoring such accounts receivable on our consolidated condensed results of operations for the three months ended March 31, 2017 and 2016 was not material.

The entire disclosure for the fair value of financial instruments (as defined), including financial assets and financial liabilities (collectively, as defined), and the measurements of those instruments as well as disclosures related to the fair value of non-financial assets and liabilities. Such disclosures about the financial instruments, assets, and liabilities would include: (1) the fair value of the required items together with their carrying amounts (as appropriate); (2) for items for which it is not practicable to estimate fair value, disclosure would include: (a) information pertinent to estimating fair value (including, carrying amount, effective interest rate, and maturity, and (b) the reasons why it is not practicable to estimate fair value; (3) significant concentrations of credit risk including: (a) information about the activity, region, or economic characteristics identifying a concentration, (b) the maximum amount of loss the entity is exposed to based on the gross fair value of the related item, (c) policy for requiring collateral or other security and information as to accessing such collateral or security, and (d) the nature and brief description of such collateral or security; (4) quantitative information about market risks and how such risks are managed; (5) for items measured on both a recurring and nonrecurring basis information regarding the inputs used to develop the fair value measurement; and (6) for items presented in the financial statement for which fair value measurement is elected: (a) information necessary to understand the reasons for the election, (b) discussion of the effect of fair value changes on earnings, (c) a description of [similar groups] items for which the election is made and the relation thereof to the balance sheet, the aggregate carrying value of items included in the balance sheet that are not eligible for the election; (7) all other required (as defined) and desired information.

+ References + Details

Shareholders' Equity	3 Months Ended
Shareholders' Equity	Mar. 31, 2017
Equity, Class of Treasury Stock [Line Items]
Stockholders' Equity Note Disclosure [Text Block]	Note 7: Shareholders’ Equity During the three months ended March 31, 2017 and 2016, we repurchased $60.0 million and $300.1 million of shares, respectively, associated with our $5.00 billion share repurchase program announced in October 2013. As of March 31, 2017, there were $2.35 billion of shares remaining in that program. Our share repurchases are facilitated through payments to a financial institution that purchases the shares on our behalf. As of December 31, 2016, we had paid $60.0 million to a financial institution for shares that were subsequently repurchased in the first quarter of 2017.

The entire disclosure for shareholders' equity comprised of portions attributable to the parent entity and noncontrolling interest, including other comprehensive income. Includes, but is not limited to, balances of common stock, preferred stock, additional paid-in capital, other capital and retained earnings, accumulated balance for each classification of other comprehensive income and amount of comprehensive income.

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Defined Benefit Plans and Other Postretirement Benefit Plans Disclosures [Abstract]

Income Taxes	3 Months Ended
Income Taxes	Mar. 31, 2017
Income Tax Disclosure [Abstract]
Income Taxes [Text Block]	Note 8: Income Taxes During the first three months of 2017, we incurred $172.0 million of income tax expense, despite earning $61.2 million of income before income taxes, as a result of the nondeductible $857.6 million acquired IPR&D charge for the acquisition of CoLucid. During the first quarter of 2016, we completed and effectively settled the U.S. examination of tax years 2010-2012. As a result of this resolution, our gross uncertain tax positions were reduced by approximately $140 million, and our consolidated condensed results of operations benefited from an immaterial reduction in income tax expense. During 2016, we made cash payments of approximately $150 million related to tax years 2010-2012 after application of available tax credit carryforwards and carrybacks. The U.S. examination of tax years 2013-2015 began in 2016. Because the examination of years 2013-2015 is still in the early stages, the resolution of matters in this audit period will likely extend beyond the next 12 months.

Retirement Benefits

3 Months Ended

Mar. 31, 2017

Retirement Benefits [Text Block]

Note 9: Retirement Benefits

Net pension and retiree health benefit (income) cost included the following components:



	Defined Benefit Pension Plans
	Three Months Ended March 31,
	2017			2016
Components of net periodic benefit cost:
Service cost	$	78.9		$	71.3
Interest cost	102.4			105.1
Expected return on plan assets	(194.0		)	(189.6		)
Amortization of prior service cost	1.4			6.0
Recognized actuarial loss	72.7			68.3
Net periodic benefit cost	$	61.4		$	61.1



	Retiree Health Benefit Plans
	Three Months Ended March 31,
	2017			2016
Components of net periodic benefit income:
Service cost	$	11.2		$	9.3
Interest cost	13.0			12.8
Expected return on plan assets	(40.3		)	(37.5		)
Amortization of prior service benefit	(22.5		)	(21.4		)
Recognized actuarial loss	4.1			5.2
Net periodic benefit income	$	(34.5	)	$	(31.6	)

We have contributed approximately $15 million required to satisfy minimum funding requirements to our defined benefit pension and retiree health benefit plans during the three months ended March 31, 2017. Additional discretionary funding in the aggregate was not material during the three months ended March 31, 2017. During the remainder of 2017, we expect to make contributions to our defined benefit pension and retiree health benefit plans of approximately $35 million to satisfy minimum funding requirements. Additional discretionary funding for the remainder of 2017 is not expected to be material.

Contingencies	3 Months Ended
Contingencies	Mar. 31, 2017
Loss Contingency, Information about Litigation Matters [Abstract]
Contingencies [Text Block]	Note 10: Contingencies We are a party to various legal actions and government investigations. The most significant of these are described below. It is not possible to determine the outcome of these matters, and we cannot reasonably estimate the maximum potential exposure or the range of possible loss in excess of amounts accrued for any of these matters; however, we believe that, except as noted below with respect to the Alimta^® patent litigation and administrative proceedings, the resolution of all such matters will not have a material adverse effect on our consolidated financial position or liquidity, but could possibly be material to our consolidated results of operations in any one accounting period. Alimta Patent Litigation and Administrative Proceedings A number of generic manufacturers are seeking approvals in various countries to market generic forms of Alimta prior to the expiration of our vitamin regimen patents, alleging that those patents are invalid, not infringed, or both. We believe our Alimta vitamin regimen patents are valid and enforceable against these generic manufacturers. However, it is not possible to determine the ultimate outcome of the proceedings, and accordingly, we can provide no assurance that we will prevail. An unfavorable outcome could have a material adverse impact on our future consolidated results of operations, liquidity, and financial position. We expect that a loss of exclusivity for Alimta would result in a rapid and severe decline in future revenues for the product in the relevant market. U.S. Patent Litigation and Administrative Proceedings We are engaged in various U.S. patent litigation matters involving Alimta brought pursuant to procedures set out in the Drug Price Competition and Patent Term Restoration Act of 1984 (the Hatch-Waxman Act). More than ten Abbreviated New Drug Applications (ANDAs) seeking approval to market generic versions of Alimta prior to the expiration of our vitamin regimen patent (expiring in 2021 plus pediatric exclusivity expiring in 2022) have been filed by a number of companies, including Teva Parenteral Medicines, Inc. (Teva) and APP Pharmaceuticals, LLC (APP). These companies have also alleged the patent is invalid. In October 2010, we filed a lawsuit in the U.S. District Court for the Southern District of Indiana against Teva, APP and two other defendants seeking rulings that the U.S. vitamin regimen patent is valid and infringed (the Teva/APP litigation). A trial occurred in August 2013; the sole issue before the district court at that time was to determine patent validity. In March 2014, the court ruled that the asserted claims of the vitamin regimen patent are valid. The U.S. District Court for the Southern District of Indiana held a hearing on the issue of infringement in May 2015. In September 2015, the district court ruled that the vitamin regimen patent would be infringed by the generic challengers' proposed products. Teva and APP appealed all of the district court’s substantive decisions. In January 2017, the U.S. Court of Appeals for the Federal Circuit affirmed the district court’s decisions concerning validity and infringement. The defendants did not file for writ of certiorari with the U.S. Supreme Court, making the Court of Appeal's decision final. From 2012 through 2017, we filed similar lawsuits against other ANDA defendants seeking a ruling that our patents are valid and infringed. Some of these cases have been stayed pending the outcome of the Teva/APP litigation, and several parties have agreed to be bound by the outcome of the Teva/APP litigation; the remaining cases have been administratively closed. We have filed lawsuits alleging infringement against Dr. Reddy's Laboratories, Hospira, Inc., and Actavis LLC in response to their alternative forms of pemetrexed products. In June 2016, the United States Patent and Trademark Office (USPTO) granted petitions by Neptune Generics, LLC and Sandoz Inc. seeking inter partes review (IPR) of our vitamin regimen patent. Several additional generic companies have filed petitions and joined these proceedings. The final written IPR decisions are expected in June 2017. European Patent Litigation and Administrative Proceedings Generic manufacturers filed an opposition to the European Patent Office's (EPO) decision to grant us a vitamin regimen patent. The Opposition Division of the EPO upheld the patent and the generic manufacturers lodged an appeal. In October 2015 the generic manufacturers withdrew the appeal. As a result, the original EPO decision upholding the patent is now final. In addition, in the United Kingdom (U.K.), Actavis Group ehf and other Actavis companies (collectively, Actavis) filed litigation asking for a declaratory judgment that commercialization of certain salt forms of pemetrexed (the active ingredient in Alimta) diluted in saline solution would not infringe the vitamin regimen patents for Alimta in the U.K., Italy, France, and Spain. In May 2014, the trial court ruled that the vitamin regimen patents for Alimta would not be infringed by commercialization of alternative salt forms of pemetrexed, after expiration of the compound patents in December 2015. We appealed, and in June 2015, the U.K. Court of Appeal reversed the trial court's decision granting declarations of non-infringement over the Alimta vitamin regimen patents in those countries, ruling that the Alimta vitamin regimen patent would be infringed by commercialization of Actavis' products as proposed to be diluted in saline solution prior to the patent's expiration in June 2021. In February 2016, the U.K. Supreme Court granted our and Actavis' requests for permission to appeal different aspects of the judgment. A hearing took place in April 2017. In parallel proceedings, Actavis returned to the lower court seeking a declaration of non-infringement for a different proposed product diluted in dextrose solution. In February 2016, the trial court ruled that Actavis’ commercialization of this product would not infringe the patent in the U.K., Italy, France, and Spain. We have sought to appeal this ruling. We commenced separate infringement proceedings against certain Actavis companies in Germany. Following a trial, in April 2014, the German trial court ruled in our favor. The defendants appealed, and after a hearing in March 2015, the German Court of Appeal overturned the trial court and ruled that our vitamin regimen patent in Germany would not be infringed by a dipotassium salt form of pemetrexed. In June 2016, the German Federal Supreme Court granted our appeal, vacating the prior decision denying infringement, and returned the case to the Court of Appeal to reconsider infringement based on its judgment. In separate proceedings, in May 2016 and June 2016, the German courts confirmed preliminary injunctions against Hexal AG (Hexal), which had stated its intention to launch a generic disodium salt product diluted in saline solution in Germany, and ratiopharm GmbH, a subsidiary of Teva, which had stated its intention to launch a proposed alternative salt form of pemetrexed product diluted in dextrose solution. Hexal has separately filed a challenge to the validity of our vitamin regimen patent before the German Federal Patent court. In late 2016, the German courts issued preliminary injunctions against two other companies that had stated their intentions to launch a proposed alternative salt form of pemetrexed product diluted in dextrose solution. We do not anticipate any generic entry into the German market at least until the Court of Appeal proceedings against Actavis considers the issues remanded by the German Federal Supreme Court or the injunctions are lifted. Additional legal proceedings are ongoing in various national courts of other European countries. We are aware that generic competitors have received approval to market generic versions of pemetrexed in major European markets and generics have launched in two major European markets. Japanese Administrative Proceedings Three separate demands for invalidation of our two vitamin regimen patents, involving several companies, have been filed with the Japanese Patent Office (JPO). In November 2015, the JPO issued written decisions in the invalidation trial initiated by Sawai Pharmaceutical Co., Ltd. (Sawai), which had been joined by three other companies, upholding both vitamin regimen patents. In February 2017, the Japan Intellectual Property High Court confirmed the decisions of the JPO and ruled in our favor in the invalidation trials initiated by Sawai. The Japan Intellectual Property High Court’s decision regarding the demand initiated by Sawai is now final. These patents provide intellectual property protection for Alimta until June 2021. The remaining two separate demands are currently suspended but may resume now that the High Court decision relating to the first demand is final. Notwithstanding our patents, generic versions of Alimta were approved in Japan starting in February 2016. We do not currently anticipate that generic versions of Alimta will proceed to pricing approval. Effient Patent Litigation and Administrative Proceedings We, along with Daiichi Sankyo, Daiichi Sankyo, Inc., and Ube Industries (Ube) are engaged in U.S. patent litigation involving Effient brought pursuant to procedures set out in the Hatch-Waxman Act. More than 10 different companies have submitted ANDAs seeking approval to market generic versions of Effient prior to the expiration of Daiichi Sankyo’s and Ube’s patents (expiring in 2023) covering methods of using Effient with aspirin, and alleging the patents are invalid. One of these ANDAs also alleged that the compound patent for Effient (expiring in April 2017) was invalid. We have entered into a settlement relating to the compound patent litigation and anticipate that a generic version could launch as early as mid-August 2017. Beginning in March 2014, we filed lawsuits in the U.S. District Court for the Southern District of Indiana against these companies, seeking a ruling that the patents are valid and infringed. These cases have been consolidated. In 2015, several generic pharmaceutical companies filed petitions with the USPTO, requesting IPR of the method patents. In September 2016, the USPTO determined that the method-of-use patents are invalid. Daiichi Sankyo and Ube have appealed these decisions to the U.S. Court of Appeals for the Federal Circuit. We expect a final decision in late 2017. The consolidated lawsuit is currently stayed with respect to all parties pending the outcome of this appeal. We believe the Effient patents are valid and enforceable against these generic manufacturers. However, it is not possible to determine the outcome of the proceedings, and accordingly, we can provide no assurance that we will prevail. We expect a loss of exclusivity for Effient would result in a rapid and severe decline in future revenues for the product in the relevant market. Actos^® Product Liability Litigation We have been named along with Takeda Chemical Industries, Ltd., and Takeda affiliates (collectively, Takeda) as a defendant in approximately 6,500 product liability cases in the U.S. related to the diabetes medication Actos, which we co-promoted with Takeda in the U.S. from 1999 until 2006. In general, plaintiffs in these actions allege that Actos caused or contributed to their bladder cancer. Almost all of the active cases have been consolidated in federal multidistrict litigation in the Western District of Louisiana or are pending in a coordinated state court proceeding in California or a coordinated state court proceeding in Illinois. In April 2015, Takeda announced they will pay approximately $2.4 billion to resolve the vast majority of the U.S. product liability lawsuits involving Actos. Although the vast majority of U.S. product liability lawsuits involving Actos are included in the resolution program, there may be additional cases pending against Takeda and us following completion of the resolution program. Our agreement with Takeda calls for Takeda to defend and indemnify us against our losses and expenses with respect to the U.S. litigation arising out of the manufacture, use, or sale of Actos and other related expenses in accordance with the terms of the agreement. We believe we are entitled to full indemnification of our losses and expenses in the U.S. cases; however, there can be no guarantee we will ultimately be successful in obtaining full indemnification. We are also named along with Takeda as a defendant in three purported product liability class actions in Canada related to Actos, including one in Ontario (Casseres et al. v. Takeda Pharmaceutical North America, Inc., et al. and Carrier et al. v. Eli Lilly et al.), one in Quebec (Whyte et al. v. Eli Lilly et al.), and one in Alberta (Epp v. Takeda Canada et al.). We promoted Actos in Canada until 2009. We believe these lawsuits are without merit, and we and Takeda are prepared to defend against them vigorously. Cymbalta^® Product Liability Litigation In October 2012, we were named as a defendant in a purported class-action lawsuit in the U.S. District Court for the Central District of California (now called Strafford et al. v. Eli Lilly and Company) involving Cymbalta. The plaintiffs, purporting to represent a class of all persons within the U.S. who purchased and/or paid for Cymbalta, asserted claims under the consumer protection statutes of four states, California, Massachusetts, Missouri, and New York, and sought declaratory, injunctive, and monetary relief for various alleged economic injuries arising from discontinuing treatment with Cymbalta. In December 2014, the district court denied the plaintiffs' motion for class certification. Plaintiffs filed a petition with the U.S. Court of Appeals for the Ninth Circuit requesting permission to file an interlocutory appeal of the denial of class certification, which was denied. Plaintiffs filed a second motion for certification under the consumer protection acts of New York and Massachusetts. The district court denied that motion for class certification in July 2015. The district court dismissed the suit and plaintiffs are appealing to the U.S. Court of Appeals for the Ninth Circuit. Oral argument is expected in late 2017. We are named in approximately 140 lawsuits involving approximately 1,470 plaintiffs filed in various federal and state courts alleging injuries arising from discontinuation of treatment with Cymbalta. These include approximately 40 individual and multi-plaintiff cases filed in California state court, centralized in a California Judicial Counsel Coordination Proceeding pending in Los Angeles. The first individual product liability cases were tried in August 2015 and resulted in defense verdicts against four plaintiffs. We believe all these Cymbalta lawsuits and claims are without merit. We have reached a settlement framework which provides for a comprehensive resolution of nearly all of these personal injury claims, filed or unfiled, alleging injuries from discontinuing treatment with Cymbalta. There can be no assurances, however, that a final settlement will be reached. Brazil–Employee Litigation Our subsidiary in Brazil, Eli Lilly do Brasil Limitada (Lilly Brasil), is named in a lawsuit brought by the Labor Attorney for 15th Region in the Labor Court of Paulinia, State of Sao Paulo, Brazil, alleging possible harm to employees and former employees caused by exposure to heavy metals at a former Lilly manufacturing facility in Cosmopolis, Brazil, operated by the company between 1977 and 2003. The plaintiffs allege that some employees at the facility were exposed to benzene and heavy metals; however, Lilly Brasil maintains that these alleged contaminants were never used in the facility. In May 2014, the labor court judge ruled against Lilly Brasil. The judge's ruling orders Lilly Brasil to undertake several actions of unspecified financial impact, including paying lifetime medical insurance for the employees and contractors who worked at the Cosmopolis facility more than six months during the affected years and their children born during and after this period. While we cannot currently estimate the range of reasonably possible financial losses that could arise in the event we do not ultimately prevail in the litigation. The judge has estimated the total financial impact of the ruling to be approximately 1.0 billion Brazilian real (approximately $315 million as of March 31, 2017) plus interest. We strongly disagree with the decision and filed an appeal in May 2014. We are also named in approximately 30 lawsuits filed in the same court by individual former employees making similar claims. We believe these lawsuits are without merit and are prepared to defend against them vigorously. Product Liability Insurance Because of the nature of pharmaceutical products, it is possible that we could become subject to large numbers of product liability and related claims in the future. Due to a very restrictive market for product liability insurance, we are self-insured for product liability losses for all our currently marketed products.

Other Comprehensive Income (Loss) Other Comprehensive Income (Loss) (Notes)

3 Months Ended

Mar. 31, 2017

Comprehensive Income (Loss) Note [Text Block]

Note 11: Other Comprehensive Income (Loss)

The following tables summarize the activity related to each component of other comprehensive income (loss) during the three months ended March 31, 2017 and 2016:



(Amounts presented net of taxes)	Foreign Currency Translation Gains (Losses)			Unrealized Net Gains (Losses) on Securities			Defined Benefit Pension and Retiree Health Benefit Plans			Effective Portion of Cash Flow Hedges			Accumulated Other Comprehensive Loss
Balance at January 1, 2017 ⁽¹⁾	$	(1,867.3	)	$	224.0		$	(3,371.6	)	$	(210.9	)	$	(5,225.8	)

Other comprehensive income (loss) before reclassifications	218.6			(11.8		)	(16.9		)	—			189.9
Net amount reclassified from accumulated other comprehensive loss	—			(32.8		)	39.1			2.5			8.8
Net other comprehensive income (loss)	218.6			(44.6		)	22.2			2.5			198.7

Balance at March 31, 2017 ⁽²⁾	$	(1,648.7	)	$	179.4		$	(3,349.4	)	$	(208.4	)	$	(5,027.1	)



(Amounts presented net of taxes)	Foreign Currency Translation Gains (Losses)			Unrealized Net Gains (Losses) on Securities		Defined Benefit Pension and Retiree Health Benefit Plans			Effective Portion of Cash Flow Hedges			Accumulated Other Comprehensive Loss
Balance at January 1, 2016 ⁽¹⁾	$	(1,360.2	)	$	10.1	$	(3,012.1	)	$	(218.5	)	$	(4,580.7	)

Other comprehensive income (loss) before reclassifications	200.3			4.2		(4.1		)	—			200.4
Net amount reclassified from accumulated other comprehensive loss	74.5			3.6		35.1			2.4			115.6
Net other comprehensive income	274.8			7.8		31.0			2.4			316.0

Balance at March 31, 2016 ⁽²⁾	$	(1,085.4	)	$	17.9	$	(2,981.1	)	$	(216.1	)	$	(4,264.7	)

⁽¹⁾Accumulated other comprehensive loss as of January 1, 2017 consists of $5,274.0 million of accumulated other comprehensive loss attributable to controlling interest and $48.2 million of accumulated other comprehensive income attributable to non-controlling interest. The accumulated other comprehensive loss attributable to non-controlling interest as of January 1, 2016 is immaterial.

⁽²⁾ Accumulated other comprehensive loss as of March 31, 2017 consists of $5,064.3 million of accumulated other comprehensive loss attributable to controlling interest and $37.2 million of accumulated other comprehensive income attributable to non-controlling interest. The accumulated other comprehensive loss attributable to non-controlling interest as of March 31, 2016 is immaterial.

The tax effects on the net activity related to each component of other comprehensive income (loss) were as follows:



	Three Months Ended March 31,
Tax benefit (expense)	2017			2016
Foreign currency translation gains/losses	$	29.7		$	27.7
Unrealized net gains/losses on securities	18.1			(4.2		)
Defined benefit pension and retiree health benefit plans	(8.5		)	(25.7		)
Effective portion of cash flow hedges	(1.3		)	(1.3		)
Provision for income taxes allocated to other comprehensive income (loss) items	$	38.0		$	(3.5	)

Except for the tax effects of foreign currency translation gains and losses related to our foreign currency-denominated notes, cross-currency interest rate swaps, and other foreign currency exchange contracts designated as net investment hedges (see Note 6), income taxes were not provided for foreign currency translation. Generally, the assets and liabilities of foreign operations are translated into U.S. dollars using the current exchange rate. For those operations, changes in exchange rates generally do not affect cash flows; therefore, resulting translation adjustments are made in shareholders' equity rather than in the consolidated condensed statements of operations.

Reclassifications out of accumulated other comprehensive loss were as follows:



Details about Accumulated Other Comprehensive Loss Components	Three Months Ended March 31,						Affected Line Item in the Consolidated Condensed Statements of Operations
	Three Months Ended March 31,
	2017			2016
Amortization of retirement benefit items:
Prior service benefits, net	$	(21.1	)	$	(15.4	)	⁽¹⁾
Actuarial losses, net	76.8			73.5			⁽¹⁾
Total before tax	55.7			58.1
Tax benefit	(16.6		)	(23.0		)	Income taxes
Net of tax	39.1			35.1

Unrealized gains/losses on available-for-sale securities:
Realized (gains) losses, net before tax	(50.4		)	5.5			Other–net, (income) expense
Tax (benefit) expense	17.6			(1.9		)	Income taxes
Net of tax	(32.8		)	3.6
Other, net of tax ⁽²⁾	2.5			76.9			Other–net, (income) expense
Total reclassifications for the period (net of tax)	$	8.8		$	115.6

⁽¹⁾ These accumulated other comprehensive loss components are included in the computation of net periodic benefit (income) cost (see Note 9).

⁽²⁾ Amount for the three months ended March 31, 2016 included primarily $74.5 million of foreign currency translation losses.

The entire disclosure for comprehensive income, which includes, but is not limited to, 1) the amount of income tax expense or benefit allocated to each component of other comprehensive income, including reclassification adjustments, 2) the reclassification adjustments for each classification of other comprehensive income and 3) the ending accumulated balances for each component of comprehensive income.

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-Subparagraph (SX 210.3-04)
-URI http://asc.fasb.org/extlink&oid=27012166&loc=d3e187085-122770

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-Name Accounting Standards Codification
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-Paragraph 11
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Reference 9: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Glossary Reclassification Adjustments
-URI http://asc.fasb.org/extlink&oid=6522872

Nonoperating Income (Expense) [Abstract]

Other-Net, (Income) Expense

3 Months Ended

Mar. 31, 2017

Other - Net, Expense (Income) [Text Block]

Note 12: Other–Net, (Income) Expense

Other–net, (income) expense consisted of the following:



	Three Months Ended March 31,
	2017			2016
Interest expense	$	46.6		$	43.4
Interest income	(32.6		)	(24.2		)
Venezuela charge	—			203.9
Other income	(29.1		)	(74.1		)
Other–net, (income) expense	$	(15.1	)	$	149.0

Due to the financial crisis in Venezuela and the significant deterioration of the bolívar, we changed the exchange rate used to translate the assets and liabilities of our subsidiaries in Venezuela which resulted in a first quarter of 2016 charge of $203.9 million. Prior to this change, we used the Supplementary Foreign Currency Administration System (SICAD) rate; however, this official rate was discontinued in the first quarter of 2016. After considering several factors, including the future uncertainty of the Venezuelan economy, published exchange rates, and the limited amount of foreign currency exchanged, we changed to the Divisa Complementaria (DICOM) rate.

Segment Information

3 Months Ended

Mar. 31, 2017

Segment Reporting [Abstract]

Segment Reporting Disclosure [Text Block]

Note 13: Segment Information

We have two operating segments—human pharmaceutical products and animal health products. Our operating segments are distinguished by the ultimate end user of the product—humans or animals. Performance is evaluated based on profit or loss from operations before income taxes.



	Three Months Ended March 31,
	2017		2016
Segment revenue—to unaffiliated customers:
Human pharmaceutical products:
Endocrinology:
Humalog^®	$	708.4	$	606.3
Trulicity^®	372.9		143.6
Forteo^®	347.5		318.6
Humulin^®	314.5		356.4
Trajenta	113.0		94.4
Other Endocrinology	266.8		237.4
Total Endocrinology	2,123.1		1,756.7

Oncology:
Alimta	489.9		564.2
Cyramza^®	171.2		131.0
Erbitux	154.4		168.1
Other Oncology	71.5		31.2
Total Oncology	887.0		894.5

Cardiovascular:
Cialis^®	533.6		576.7
Effient	127.8		131.5
Other Cardiovascular	35.8		46.0
Total Cardiovascular	697.2		754.2

Neuroscience:
Strattera^®	196.2		188.1
Cymbalta	174.6		198.7
Zyprexa^®	147.5		212.8
Other Neuroscience	61.0		44.1
Total Neuroscience	579.3		643.7

Other pharmaceuticals	172.4		61.4
Total human pharmaceutical products	4,459.0		4,110.5
Animal health products	769.4		754.6
Revenue	$	5,228.3	$	4,865.1



	Three Months Ended March 31,
	2017			2016
Segment profits:
Human pharmaceutical products	$	1,170.9		$	927.0
Animal health products	148.3			147.6
Total segment profits	$	1,319.2		$	1,074.6

Reconciliation of total segment profits to consolidated income before taxes:
Segment profits	$	1,319.2		$	1,074.6
Other profits (losses):
Acquired in-process research and development (Note 3)	(857.6		)	—
Amortization of intangible assets	(176.1		)	(172.5		)
Asset impairment, restructuring, and other special charges (Note 5)	(213.9		)	(131.4		)
Venezuela charge (Note 12)	—			(203.9		)
Inventory fair value adjustment related to BIVIVP (Note 3)	(10.4		)	—
Consolidated income before taxes	$	61.2		$	566.8

Numbers may not add due to rounding.

For internal management reporting presented to the chief operating decision maker, certain costs are fully allocated to our human pharmaceutical products segment and therefore are not reflected in the animal health segment's profit. Such items include costs associated with treasury-related financing, global administrative services, certain acquisition-related transaction costs, and certain manufacturing costs.

The entire disclosure for reporting segments including data and tables. Reportable segments include those that meet any of the following quantitative thresholds a) it's reported revenue, including sales to external customers and intersegment sales or transfers is 10 percent or more of the combined revenue, internal and external, of all operating segments b) the absolute amount of its reported profit or loss is 10 percent or more of the greater, in absolute amount of 1) the combined reported profit of all operating segments that did not report a loss or 2) the combined reported loss of all operating segments that did report a loss c) its assets are 10 percent or more of the combined assets of all operating segments.

Reference 1: http://www.xbrl.org/2003/role/presentationRef
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-Name Accounting Standards Codification
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New Accounting Pronouncements or Change in Accounting Principle [Line Items]

Acquisitions Business Combinations Policy [Policy Text Block] (Policies)	3 Months Ended
	Mar. 31, 2017
Accounting Policies [Abstract]
Business Combinations Policy [Policy Text Block]	Upon acquisition, the acquired in-process research and development (IPR&D) charge of $857.6 million related to this product was immediately written off as an expense because the product had no alternative future use. Under this method, the assets acquired and liabilities assumed were recorded at their respective fair values as of the acquisition date in our consolidated financial statements. The determination of estimated fair value required management to make significant estimates and assumptions. The excess of the purchase price over the fair value of the acquired net assets, where applicable, has been recorded as goodwill. The results of operations of this acquisition are included in our consolidated condensed financial statements from the date of acquisition.

Financial Instruments (Policies)	3 Months Ended
Financial Instruments (Policies)	Mar. 31, 2017
Fair Value Disclosures [Abstract]
Description of Derivative Risk Management Policy	Our derivative activities are initiated within the guidelines of documented corporate risk-management policies and offset losses and gains on the assets, liabilities, and transactions being hedged. Management reviews the correlation and effectiveness of our derivatives on a quarterly basis. For derivative instruments that are designated and qualify as fair value hedges, the derivative instrument is marked to market with gains and losses recognized currently in income to offset the respective losses and gains recognized on the underlying exposure. For derivative instruments that are designated and qualify as cash flow hedges, the effective portion of gains and losses is reported as a component of accumulated other comprehensive loss and reclassified into earnings in the same period the hedged transaction affects earnings. For derivative and non-derivative instruments that are designated and qualify as net investment hedges, the effective portion of foreign currency translation gains or losses due to spot rate fluctuations are reported as a component of accumulated other comprehensive loss. Hedge ineffectiveness is immediately recognized in earnings. Derivative contracts that are not designated as hedging instruments are recorded at fair value with the gain or loss recognized in current earnings during the period of change. We may enter into foreign currency forward or option contracts to reduce the effect of fluctuating currency exchange rates (principally the euro, British pound, and the Japanese yen). Foreign currency derivatives used for hedging are put in place using the same or like currencies and duration as the underlying exposures. Forward and option contracts are principally used to manage exposures arising from subsidiary trade and loan payables and receivables denominated in foreign currencies. These contracts are recorded at fair value with the gain or loss recognized in other–net, (income) expense. We may enter into foreign currency forward and option contracts and currency swaps as fair value hedges of firm commitments. Forward contracts generally have maturities not exceeding 12 months.

Implementation of New Financial Accounting Pronouncements Implementation of New Accounting Pronouncements (Tables)

3 Months Ended

Mar. 31, 2017

Schedule of New Accounting Pronouncements and Changes in Accounting Principles [Table Text Block]

The following table provides a brief description of accounting standards that have not yet been adopted and could have a material effect on our financial statements:



Standard	Description	Effective Date	Effect on the financial statements or other significant matters
Accounting Standards Update 2014-09 and various other related updates, Revenue from Contracts with Customers	This standard will replace existing revenue recognition standards and will require entities to recognize revenues to depict the transfer of promised goods or services to customers in an amount that reflects the consideration to which the entity expects to be entitled in exchange for those goods or services. An entity can apply the new revenue standard retrospectively to each prior reporting period presented or with the cumulative effect of initially applying the standard recognized at the date of initial application in retained earnings. We currently plan to use the latter approach.	This standard is effective January 1, 2018, and we will adopt on that date.	We are in the process of evaluating the impact of the adoption of the standard. We have identified two revenue streams from our contracts with customers: 1) product sales and 2) licensing arrangements. While our evaluation of our contracts for product sales is not yet complete, based upon the results of our work to date we currently do not expect the application of the new standard to these contracts to have a material impact to our consolidated financial statements either at initial implementation or on an ongoing basis. We are in the process of reviewing arrangements in which we have licensed or sold intellectual property and are not yet able to estimate the anticipated impact to our consolidated financial statements from the application of the new standard to our arrangements as we continue to interpret and apply the principles in the new standard to our arrangements.
Accounting Standards Update 2016-01, Financial Instruments - Overall: Recognition and Measurement of Financial Assets and Financial Liabilities	This standard will require entities to recognize changes in the fair value of equity investments with readily determinable fair values in net income (except for investments accounted for under the equity method of accounting or those that result in consolidation of the investee). An entity should apply the new standard through a cumulative effect adjustment to retained earnings as of the beginning of the fiscal year of adoption.	This standard is effective January 1, 2018. Early adoption of the majority of the amendments in this standard is not permitted, however, early application of certain amendments is permitted. We intend to fully adopt this standard on January 1, 2018.	We are unable to estimate the impact of adopting this standard as the significance of the impact will depend upon our equity investments as of the date of adoption.



Standard	Description	Effective Date	Effect on the financial statements or other significant matters
Accounting Standards Update 2016-02, Leases	This standard was issued to increase transparency and comparability among organizations by recognizing lease assets and lease liabilities, including leases classified as operating leases under current GAAP, on the balance sheet and requiring additional disclosures about leasing arrangements. This standard requires a modified retrospective approach to adoption.	This standard is effective January 1, 2019, with early adoption permitted. We intend to adopt this standard on January 1, 2019.	We are in the process of determining the potential impact on our consolidated financial statements.
Accounting Standards Update 2016-16, Income Taxes: Intra-Entity Transfers of Assets Other Than Inventory	This standard will require entities to recognize the income tax consequences of intra-entity transfers of assets other than inventory at the time of transfer. This standard requires a modified retrospective approach to adoption.	This standard is effective January 1, 2018, and we will adopt on that date.	We are continuing to assess the potential impact of this standard on our consolidated financial statements and currently estimate that the cumulative effect of initially applying the standard would result in an increase to deferred tax assets and the opening balance of retained earnings of approximately $2 billion on January 1, 2018. This estimate is subject to change based upon intra-entity transfers of assets other than inventory over the remainder of 2017 and ongoing assessments of the future deductibility and realizability of the deferred tax assets that would result from implementation.
Accounting Standards Update 2017-07, Compensation-Retirement Benefits: Improving the Presentation of Net Periodic Pension Cost and Net Periodic Postretirement Benefit Cost	This standard was issued to improve the transparency and comparability among organizations by requiring entities to separate their net periodic pension cost and net periodic postretirement benefit cost into a service cost component and other components. Currently, the costs of the other components along with the service cost component are classified based upon the function of the employee. This standard will require entities to classify the service cost component in the same financial statement line item or items as other compensation costs arising from services rendered by pertinent employees. The other components of net benefit cost will be presented separately from the line items that include the service cost component. When applicable, the service cost component will be the only component eligible for capitalization. An entity should apply the new standard retrospectively for the classification of the service cost and other components and prospectively for the capitalization of the service cost component.	This standard is effective January 1, 2018, with early adoption permitted. We intend to adopt this standard on January 1, 2018.	Upon adoption of this standard, pension and postretirement benefit cost components other than service costs will be presented in other–net, (income) expense. We do not expect the application of the new standard to have a material impact on consolidated net income either at initial implementation or on an ongoing basis.

Tabular disclosure of changes in accounting principles, including adoption of new accounting pronouncements, that describes the new methods, amount and effects on financial statement line items.

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 250
-SubTopic 10
-Section 50
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-URI http://asc.fasb.org/extlink&oid=64853466&loc=d3e22580-107794

Reference 2: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Glossary Direct Effects of a Change in Accounting Principle
-URI http://asc.fasb.org/extlink&oid=66092750

Reference 3: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Glossary Indirect Effects of a Change in Accounting Principle
-URI http://asc.fasb.org/extlink&oid=6515603

Reference 4: http://www.xbrl.org/2003/role/presentationRef
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-Name Accounting Standards Codification
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Reference 5: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Glossary Accounting Change
-URI http://asc.fasb.org/extlink&oid=6503790

Reference 6: http://www.xbrl.org/2003/role/presentationRef
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-Name Accounting Standards Codification
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Reference 7: http://www.xbrl.org/2003/role/presentationRef
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Reference 8: http://www.xbrl.org/2003/role/presentationRef
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Reference 9: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Glossary Change in Accounting Principle
-URI http://asc.fasb.org/extlink&oid=6507316

Reference 10: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
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Reference 11: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Glossary Retrospective Application
-URI http://asc.fasb.org/extlink&oid=6523989

Schedule of Research and Development Assets Acquired Other than Through Business Combination [Table Text Block]

Acquisitions Acquistions (Tables)

3 Months Ended

Mar. 31, 2017

Business Acquisition [Line Items]



Counterparty	Compound(s) or Therapy	Acquisition Month	Phase of Development ⁽¹⁾	Acquired IPR&D Expense
CoLucid Pharmaceuticals, Inc. (CoLucid)	Oral therapy for the acute treatment of migraine - lasmiditan	March 2017	Phase III	$	857.6

⁽¹⁾ The phase of development presented is as of the date of the arrangement.

Boehringer Ingelheim Vetmedica, Inc.'s U.S. Vaccine Portfolio [Member]

Business Acquisition [Line Items]

Schedule of Recognized Identified Assets Acquired and Liabilities Assumed [Table Text Block]

The following table summarizes the preliminary amounts recognized for assets acquired and liabilities assumed as of the acquisition date:



Estimated Fair Value at January 3, 2017
Inventories	$	105.2
Acquired in-process research and development	33.0
Marketed products ⁽¹⁾	404.0
Property and equipment	156.2
Other assets and liabilities - net	(0.7		)
Total identifiable net assets	697.7
Goodwill ⁽²⁾	184.4
Total consideration transferred - net of cash acquired	$	882.1

Collaborations and Other Arrangements (Tables)

3 Months Ended

Mar. 31, 2017

Diabetes Collaboration [Member]

Schedule of Collaborative Arrangements and Non-collaborative Arrangement Transactions [Table Text Block]

The table below summarizes significant regulatory and commercialization events and milestones (received) paid for the compounds included in this collaboration:



	Product Status			Milestones (Deferred) Capitalized ⁽¹⁾
Product Family	U.S.	Europe	Japan	Year	Amount
Trajenta ⁽²⁾	Launched 2011	Launched 2011	Launched 2011	2017	$	—
				2016	—
				Cumulative ⁽⁴⁾	446.4
Jardiance ⁽³⁾	Launched 2014	Launched 2014	Launched 2015	2017	—
				2016	—
				Cumulative ⁽⁴⁾	299.5
Basaglar	Launched 2016	Launched 2015	Launched 2015	2017	—
				2016	(187.5		)
				Cumulative ⁽⁴⁾	(250.0		)

⁽²⁾ Jentadueto is included in the Trajenta family of product results.

⁽³⁾ Glyxambi and Synjardyare included in the Jardiance family of product results.

⁽⁴⁾ The cumulative amount represents the total initial amounts that were (deferred) or capitalized from the start of this collaboration through the end of the reporting period.

Bi Compounds [Member]

Schedule of Collaborative Arrangements and Non-collaborative Arrangement Transactions [Table Text Block]



	Three Months Ended March 31,
	2017		2016
Trajenta	$	113.0	$	94.4
Jardiance	74.0		38.2
Basaglar	46.0		10.9

Erbitux [Member]

Schedule of Collaborative Arrangements and Non-collaborative Arrangement Transactions [Table Text Block]

The following table summarizes our revenue recognized with respect to Erbitux:



	Three Months Ended March 31,
	2017		2016
Net product revenue	$	131.3	$	141.5
Collaboration and other revenue	23.1		26.6
Revenue	$	154.4	$	168.1

Effient [Member]

Schedule of Collaborative Arrangements and Non-collaborative Arrangement Transactions [Table Text Block]

The following table summarizes our revenue recognized with respect to Effient:



	Three Months Ended March 31,
	2017		2016
Revenue	$	127.8	$	131.5

Selling, General and Administrative Expenses [Member]

Schedule of Collaborative Arrangements and Non-collaborative Arrangement Transactions [Table Text Block]



	Three Months Ended March 31,
	2017		2016
Marketing, selling, and administrative	$	46.7	$	49.0

Collaborative Arrangement [Member]

Schedule of Collaborative Arrangements and Non-collaborative Arrangement Transactions [Table Text Block]

The following table summarizes our collaboration and other revenue, which is included in revenue in the consolidated condensed statements of operations:



	Three Months Ended March 31,
	2017		2016
Collaboration and other revenue	$	240.4	$	182.3

Asset Impairment, Restructuring, and Other Special Charges Asset Impairment, Restructuring, and Other Special Charges (Tables)

3 Months Ended

Mar. 31, 2017

Restructuring Cost and Reserve [Line Items]

Restructuring and Related Costs [Table Text Block]

The components of the charges included in asset impairment, restructuring, and other special charges in our consolidated condensed statements of operations are described below.



	Three Months Ended March 31,
	2017		2016
Severance:
Human pharmaceutical products	$	113.1	$	—
Animal health products	55.6		9.5
Total severance	168.7		9.5
Asset impairment and other special charges:
Animal health products	45.2		121.9
Total asset impairment, restructuring, and other special charges	$	213.9	$	131.4

Financial Instruments (Tables)

3 Months Ended

Mar. 31, 2017

Fair Value Disclosures [Abstract]

Schedule of Derivatives Instruments Statements of Financial Performance and Financial Position, Location [Table Text Block]

The following effects of risk-management instruments were recognized in other–net, (income) expense:



	Three Months Ended March 31,
	2017			2016
Fair value hedges:
Effect from hedged fixed-rate debt	$	(7.5	)	$	75.3
Effect from interest rate contracts	7.5			(75.3		)
Cash flow hedges:
Effective portion of losses on interest rate contracts reclassified from accumulated other comprehensive loss	3.8			3.7
Net losses on foreign currency exchange contracts not designated as hedging instruments	37.2			13.3

Fair Value, Assets Measured on Recurring Basis [Table Text Block]



					Fair Value Measurements Using
	Carrying Amount		Cost ⁽¹⁾		Quoted Prices in Active Markets for Identical Assets (Level 1)		Significant Other Observable Inputs (Level 2)		Significant Unobservable Inputs (Level 3)		Fair Value
March 31, 2017
Cash equivalents	$	990.5	$	990.5	$	916.8	$	73.7	$	—	$	990.5

Short-term investments:
U.S. government and agency securities	$	98.9	$	99.0	$	98.9	$	—	$	—	$	98.9
Corporate debt securities	784.7		784.4		—		784.7		—		784.7
Asset-backed securities	3.0		3.0		—		3.0		—		3.0
Other securities	2.1		2.1		—		2.1		—		2.1
Short-term investments	$	888.7

Noncurrent investments:
U.S. government and agency securities	$	359.1	$	363.2	$	359.1	$	—	$	—	$	359.1
Corporate debt securities	3,188.0		3,191.3		—		3,188.0		—		3,188.0
Mortgage-backed securities	171.5		173.6		—		171.5		—		171.5
Asset-backed securities	513.4		514.3		—		513.4		—		513.4
Other securities	167.1		83.3		—		—		167.1		167.1
Marketable equity securities	340.1		78.3		340.1		—		—		340.1
Cost and equity method investments ⁽²⁾	558.5
Noncurrent investments	$	5,297.7

December 31, 2016
Cash equivalents	$	2,986.8	$	2,986.8	$	2,699.4	$	287.4	$	—	$	2,986.8

Short-term investments:
U.S. government and agency securities	$	232.5	$	232.6	$	232.5	$	—	$	—	$	232.5
Corporate debt securities	1,219.2		1,219.1		—		1,219.2		—		1,219.2
Asset-backed securities	4.3		4.3		—		4.3		—		4.3
Other securities	0.5		0.5		—		0.5		—		0.5
Short-term investments	$	1,456.5

Noncurrent investments:
U.S. government and agency securities	$	318.9	$	323.8	$	318.9	$	—	$	—	$	318.9
Corporate debt securities	3,062.2		3,074.3		—		3,062.2		—		3,062.2
Mortgage-backed securities	183.1		185.4		—		183.1		—		183.1
Asset-backed securities	502.7		503.5		—		502.7		—		502.7
Other securities	153.7		77.6		—		—		153.7		153.7
Marketable equity securities	418.2		91.9		418.2		—		—		418.2
Cost and equity method investments ⁽²⁾	568.7
Noncurrent investments	$	5,207.5

⁽¹⁾ For available-for-sale debt securities, amounts disclosed represent the securities' amortized cost.

⁽²⁾ Fair value disclosures are not applicable for cost method and equity method investments.

Fair Value, Liabilities Measured on Recurring Basis [Table Text Block]



				Fair Value Measurements Using
	Carrying Amount			Quoted Prices in Active Markets for Identical Assets (Level 1)		Significant Other Observable Inputs (Level 2)			Significant Unobservable Inputs (Level 3)		Fair Value
Short-term commercial paper borrowings
March 31, 2017	$	(1,799.7	)	$	—	$	(1,798.8	)	$	—	$	(1,798.8	)
December 31, 2016	(1,299.3		)	—		(1,299.3		)	—		(1,299.3		)
Long-term debt, including current portion
March 31, 2017	$	(8,447.1	)	$	—	$	(8,760.8	)	$	—	$	(8,760.8	)
December 31, 2016	(9,005.9		)	—		(9,419.1		)	—		(9,419.1		)

Fair Value, by Balance Sheet Grouping [Table Text Block]



				Fair Value Measurements Using
	Carrying Amount			Quoted Prices in Active Markets for Identical Assets (Level 1)		Significant Other Observable Inputs (Level 2)			Significant Unobservable Inputs (Level 3)			Fair Value
March 31, 2017
Risk-management instruments:
Interest rate contracts designated as fair value hedges:
Other receivables	$	4.3		$	—	$	4.3		$	—		$	4.3
Sundry	28.9			—		28.9			—			28.9
Other current liabilities	(0.4		)	—		(0.4		)	—			(0.4		)
Other noncurrent liabilities	(1.0		)	—		(1.0		)	—			(1.0		)
Cross-currency interest rate contracts designated as net investment hedges:
Other receivables	5.3			—		5.3			—			5.3
Sundry	21.3			—		21.3			—			21.3
Foreign exchange contracts not designated as hedging instruments:
Other receivables	8.2			—		8.2			—			8.2
Other current liabilities	(49.5		)	—		(49.5		)	—			(49.5		)
Contingent consideration liabilities ⁽¹⁾:
Other current liabilities	(213.8		)	—		—			(213.8		)	(213.8		)
Other noncurrent liabilities	(189.4		)	—		—			(189.4		)	(189.4		)

December 31, 2016
Risk-management instruments:
Interest rate contracts designated as fair value hedges:
Other receivables	$	2.4		$	—	$	2.4		$	—		$	2.4
Sundry	37.0			—		37.0			—			37.0
Other noncurrent liabilities	(0.5		)	—		(0.5		)	—			(0.5		)
Cross-currency interest rate contracts designated as net investment hedges:
Sundry	31.4			—		31.4			—			31.4
Foreign exchange contracts not designated as hedging instruments:
Other receivables	31.8			—		31.8			—			31.8
Other current liabilities	(21.7		)	—		(21.7		)	—			(21.7		)
Contingent consideration liabilities ⁽¹⁾:
Other current liabilities	(215.9		)	—		—			(215.9		)	(215.9		)
Other noncurrent liabilities	(242.6		)	—		—			(242.6		)	(242.6		)

Available-for-sale Securities [Table Text Block]

The table below summarizes the contractual maturities of our investments in debt securities measured at fair value as of March 31, 2017:



	Maturities by Period
	Total		Less Than 1 Year		1-5 Years		6-10 Years		More Than 10 Years
Fair value of debt securities	$	5,118.5	$	886.6	$	3,871.7	$	151.2	$	209.0



	March 31, 2017		December 31, 2016
Unrealized gross gains	$	280.5	$	352.6
Unrealized gross losses	24.6		34.1
Fair value of securities in an unrealized gain position	2,173.7		1,869.7
Fair value of securities in an unrealized loss position	3,030.5		3,262.3

Gain (Loss) on Investments [Table Text Block]

Activity related to our investment portfolio, substantially all of which related to available-for-sale securities, was as follows:



	Three Months Ended March 31,
	2017		2016
Proceeds from sales	$	1,092.5	$	726.4
Realized gross gains on sales	51.7		1.8
Realized gross losses on sales	1.3		7.3

Schedule of Derivative Instruments, Effect on Other Comprehensive Income (Loss) [Table Text Block]

The effective portion of risk-management instruments that was recognized in other comprehensive income (loss) is as follows:



	Three Months Ended March 31,
	2017			2016
Net investment hedges:
Foreign currency-denominated notes	$	(78.9	)	$	(77.8	)
Cross-currency interest rate swaps	(6.0		)	(1.2		)

Tabular disclosure of available-for-sale securities which includes, but is not limited to, changes in the cost basis and fair value, fair value and gross unrealized gain (loss), fair values by type of security, contractual maturity and classification, amortized cost basis, contracts to acquire securities to be accounted for as available-for-sale, debt maturities, transfers to trading, change in net unrealized holding gain (loss) net of tax, continuous unrealized loss position fair value, aggregate losses qualitative disclosures, other than temporary impairment (OTTI) losses or other disclosures related to available for sale securities.

+ References + Details

Pension Plans, Defined Benefit [Member]

Tabular disclosure of the realized and unrealized gains and losses reported in the statement of income which have resulted from the sale and holding of marketable securities, respectively, as well as the sale or disposal of cost method investments. Such amounts would include realized gains and losses on the sale or disposal of trading, available-for-sale, and held-to-maturity securities, unrealized gains and losses on trading securities, unrealized gains and losses on available-for-sale and held-to-maturity securities transferred to the trading securities category, realized gains and losses on the sale or disposal of cost method investments, and losses recognized for other than temporary impairments (OTTI) of such investments.

+ References + Details

Retirement Benefits (Tables)

3 Months Ended

Mar. 31, 2017

Schedule of Net Benefit Costs [Table Text Block]

Net pension and retiree health benefit (income) cost included the following components:



	Defined Benefit Pension Plans
	Three Months Ended March 31,
	2017			2016
Components of net periodic benefit cost:
Service cost	$	78.9		$	71.3
Interest cost	102.4			105.1
Expected return on plan assets	(194.0		)	(189.6		)
Amortization of prior service cost	1.4			6.0
Recognized actuarial loss	72.7			68.3
Net periodic benefit cost	$	61.4		$	61.1

Other Postretirement Benefit Plans, Defined Benefit [Member]

Schedule of Net Benefit Costs [Table Text Block]



	Retiree Health Benefit Plans
	Three Months Ended March 31,
	2017			2016
Components of net periodic benefit income:
Service cost	$	11.2		$	9.3
Interest cost	13.0			12.8
Expected return on plan assets	(40.3		)	(37.5		)
Amortization of prior service benefit	(22.5		)	(21.4		)
Recognized actuarial loss	4.1			5.2
Net periodic benefit income	$	(34.5	)	$	(31.6	)

Other Comprehensive Income (Loss) Other Comprehensive Income (Loss) (Tables)

3 Months Ended

Mar. 31, 2017

Accumulated Other Comprehensive Income (Loss) [Line Items]

Schedule of Accumulated Other Comprehensive Income (Loss) [Table Text Block]



(Amounts presented net of taxes)	Foreign Currency Translation Gains (Losses)			Unrealized Net Gains (Losses) on Securities		Defined Benefit Pension and Retiree Health Benefit Plans			Effective Portion of Cash Flow Hedges			Accumulated Other Comprehensive Loss
Balance at January 1, 2016 ⁽¹⁾	$	(1,360.2	)	$	10.1	$	(3,012.1	)	$	(218.5	)	$	(4,580.7	)

Other comprehensive income (loss) before reclassifications	200.3			4.2		(4.1		)	—			200.4
Net amount reclassified from accumulated other comprehensive loss	74.5			3.6		35.1			2.4			115.6
Net other comprehensive income	274.8			7.8		31.0			2.4			316.0

Balance at March 31, 2016 ⁽²⁾	$	(1,085.4	)	$	17.9	$	(2,981.1	)	$	(216.1	)	$	(4,264.7	)

The following tables summarize the activity related to each component of other comprehensive income (loss) during the three months ended March 31, 2017 and 2016:



(Amounts presented net of taxes)	Foreign Currency Translation Gains (Losses)			Unrealized Net Gains (Losses) on Securities			Defined Benefit Pension and Retiree Health Benefit Plans			Effective Portion of Cash Flow Hedges			Accumulated Other Comprehensive Loss
Balance at January 1, 2017 ⁽¹⁾	$	(1,867.3	)	$	224.0		$	(3,371.6	)	$	(210.9	)	$	(5,225.8	)

Other comprehensive income (loss) before reclassifications	218.6			(11.8		)	(16.9		)	—			189.9
Net amount reclassified from accumulated other comprehensive loss	—			(32.8		)	39.1			2.5			8.8
Net other comprehensive income (loss)	218.6			(44.6		)	22.2			2.5			198.7

Balance at March 31, 2017 ⁽²⁾	$	(1,648.7	)	$	179.4		$	(3,349.4	)	$	(208.4	)	$	(5,027.1	)

The tax effects on the net activity related to each component of other comprehensive income (loss) were as follows:



	Three Months Ended March 31,
Tax benefit (expense)	2017			2016
Foreign currency translation gains/losses	$	29.7		$	27.7
Unrealized net gains/losses on securities	18.1			(4.2		)
Defined benefit pension and retiree health benefit plans	(8.5		)	(25.7		)
Effective portion of cash flow hedges	(1.3		)	(1.3		)
Provision for income taxes allocated to other comprehensive income (loss) items	$	38.0		$	(3.5	)



(Amounts presented net of taxes)	Foreign Currency Translation Gains (Losses)			Unrealized Net Gains (Losses) on Securities		Defined Benefit Pension and Retiree Health Benefit Plans			Effective Portion of Cash Flow Hedges			Accumulated Other Comprehensive Loss
Balance at January 1, 2016	$	(1,360.2	)	$	10.1	$	(3,012.1	)	$	(218.5	)	$	(4,580.7	)

Other comprehensive income (loss) before reclassifications	200.3			4.2		(4.1		)	—			200.4
Net amount reclassified from accumulated other comprehensive loss	74.5			3.6		35.1			2.4			115.6
Net other comprehensive income (loss)	274.8			7.8		31.0			2.4			316.0

Balance at March 31, 2016	$	(1,085.4	)	$	17.9	$	(2,981.1	)	$	(216.1	)	$	(4,264.7	)



(Amounts presented net of taxes)	Foreign Currency Translation Gains (Losses)			Unrealized Net Gains (Losses) on Securities			Defined Benefit Pension and Retiree Health Benefit Plans			Effective Portion of Cash Flow Hedges			Accumulated Other Comprehensive Loss
Balance at January 1, 2017	$	(1,867.3	)	$	224.0		$	(3,371.6	)	$	(210.9	)	$	(5,225.8	)

Other comprehensive income (loss) before reclassifications	218.6			(11.8		)	(16.9		)	—			189.9
Net amount reclassified from accumulated other comprehensive loss	—			(32.8		)	39.1			2.5			8.8
Net other comprehensive income (loss)	218.6			(44.6		)	22.2			2.5			198.7

Balance at March 31, 2017	$	(1,648.7	)	$	179.4		$	(3,349.4	)	$	(208.4	)	$	(5,027.1	)

Schedule of Amounts Recognized in Other Comprehensive Income (Loss) [Table Text Block]

Reclassifications out of accumulated other comprehensive loss were as follows:



Details about Accumulated Other Comprehensive Loss Components	Three Months Ended March 31,						Affected Line Item in the Consolidated Condensed Statements of Operations
	Three Months Ended March 31,
	2017			2016
Amortization of retirement benefit items:
Prior service benefits, net	$	(21.1	)	$	(15.4	)	⁽¹⁾
Actuarial losses, net	76.8			73.5			⁽¹⁾
Total before tax	55.7			58.1
Tax benefit	(16.6		)	(23.0		)	Income taxes
Net of tax	39.1			35.1

Unrealized gains/losses on available-for-sale securities:
Realized (gains) losses, net before tax	(50.4		)	5.5			Other–net, (income) expense
Tax (benefit) expense	17.6			(1.9		)	Income taxes
Net of tax	(32.8		)	3.6
Other, net of tax ⁽²⁾	2.5			76.9			Other–net, (income) expense
Total reclassifications for the period (net of tax)	$	8.8		$	115.6

⁽¹⁾ These accumulated other comprehensive loss components are included in the computation of net periodic benefit (income) cost (see Note 9).

⁽²⁾ Amount for the three months ended March 31, 2016 included primarily $74.5 million of foreign currency translation losses.

Other - Net, (Income) Expense (Tables)

3 Months Ended

Mar. 31, 2017

Nonoperating Income (Expense) [Abstract]

Schedule of Other Nonoperating Income (Expense) [Table Text Block]

Other–net, (income) expense consisted of the following:



	Three Months Ended March 31,
	2017			2016
Interest expense	$	46.6		$	43.4
Interest income	(32.6		)	(24.2		)
Venezuela charge	—			203.9
Other income	(29.1		)	(74.1		)
Other–net, (income) expense	$	(15.1	)	$	149.0

Segment Information (Tables)

3 Months Ended

Mar. 31, 2017

Segment Reporting Information [Line Items]

Segment Information [Text Block]



	Three Months Ended March 31,
	2017		2016
Segment revenue—to unaffiliated customers:
Human pharmaceutical products:
Endocrinology:
Humalog^®	$	708.4	$	606.3
Trulicity^®	372.9		143.6
Forteo^®	347.5		318.6
Humulin^®	314.5		356.4
Trajenta	113.0		94.4
Other Endocrinology	266.8		237.4
Total Endocrinology	2,123.1		1,756.7

Oncology:
Alimta	489.9		564.2
Cyramza^®	171.2		131.0
Erbitux	154.4		168.1
Other Oncology	71.5		31.2
Total Oncology	887.0		894.5

Cardiovascular:
Cialis^®	533.6		576.7
Effient	127.8		131.5
Other Cardiovascular	35.8		46.0
Total Cardiovascular	697.2		754.2

Neuroscience:
Strattera^®	196.2		188.1
Cymbalta	174.6		198.7
Zyprexa^®	147.5		212.8
Other Neuroscience	61.0		44.1
Total Neuroscience	579.3		643.7

Other pharmaceuticals	172.4		61.4
Total human pharmaceutical products	4,459.0		4,110.5
Animal health products	769.4		754.6
Revenue	$	5,228.3	$	4,865.1



	Three Months Ended March 31,
	2017			2016
Segment profits:
Human pharmaceutical products	$	1,170.9		$	927.0
Animal health products	148.3			147.6
Total segment profits	$	1,319.2		$	1,074.6

Reconciliation of total segment profits to consolidated income before taxes:
Segment profits	$	1,319.2		$	1,074.6
Other profits (losses):
Acquired in-process research and development (Note 3)	(857.6		)	—
Amortization of intangible assets	(176.1		)	(172.5		)
Asset impairment, restructuring, and other special charges (Note 5)	(213.9		)	(131.4		)
Venezuela charge (Note 12)	—			(203.9		)
Inventory fair value adjustment related to BIVIVP (Note 3)	(10.4		)	—
Consolidated income before taxes	$	61.2		$	566.8

Numbers may not add due to rounding.

Basis of Presentation Basis of Presentation (Details) - USD ($) $ in Millions	3 Months Ended
	Mar. 31, 2017	Mar. 31, 2016
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Net Cash Provided by (Used in) Operating Activities	$ 339.9	$ (219.1)
Net Cash Provided by (Used in) Financing Activities	$ (875.7)	(924.2)
Adjustments for New Accounting Pronouncement [Member]
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Net Cash Provided by (Used in) Operating Activities		107.8
Net Cash Provided by (Used in) Financing Activities		$ (107.8)

Implementation of New Financial Accounting Pronouncements Implementation of New Financial Accounting Pronouncements (Details) $ in Billions	Mar. 31, 2017 USD ($)
Accounting Changes and Error Corrections [Abstract]
New Accounting Pronouncement or Change in Accounting Principle Not Yet Adopted, Estimated Cumulative Effect of Change on Equity Upon Adoption	$ 2.0
New Accounting Pronouncement or Change in Accounting Principle Not Yet Adopted, Estimated Effect of Change on Deferred Tax Assets	$ 2.0

Acquisitions (Details) - USD ($)
$ in Millions

1 Months Ended

3 Months Ended

Jan. 31, 2017

Mar. 31, 2017

Mar. 31, 2016

Jan. 03, 2017

Dec. 31, 2016

Cost of sales

$ 1,327.7

$ 1,323.0

Interest Expense

46.6

43.4

Business Combination, Pro Forma Information, Revenue of Acquiree since Acquisition Date, Actual

40.8

Payments to Acquire Businesses, Net of Cash Acquired

882.1

0.0

Goodwill

4,188.0

$ 3,972.7

Purchased in-process research and development

857.6

0.0

831.8

0.0

Boehringer Ingelheim Vetmedica, Inc.'s U.S. Vaccine Portfolio [Member]

Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Inventory

$ 105.2

Business Combination, Consideration Transferred

$ 882.1

Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Finite-Lived Intangibles

^[1]

404.0

Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Indefinite-Lived Intangible Assets

33.0

Business Combination, Consideration Transferred

882.1

Acquired Finite-lived Intangible Assets, Weighted Average Useful Life

10 years

Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Property, Plant, and Equipment

156.2

Goodwill

^[2]

184.4

Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Liabilities

(0.7)

Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Net

$ 697.7

CoLucid Pharmaceuticals [Member]

Purchased in-process research and development

857.6

831.8

Noncash or Part Noncash Acquisition, Value of Liabilities Assumed

25.8

Corporate, Non-Segment [Member]

Amortization of Intangible Assets

176.1

172.5

Corporate, Non-Segment [Member] | Fair Value Adjustment to Inventory [Member]

857.6

0.0

Cost of sales

$ 10.4

$ 0.0

[1]	(1) These intangible assets, which are being amortized to cost of sales on a straight-line basis over their estimated useful lives, were expected to have a weighted average useful life of 10 years.
[2]	(2) The goodwill recognized from this acquisition is attributable primarily to expected synergies from combining the operations of BIVIVP with our legacy animal health business, future unidentified projects and products, and the assembled workforce of BIVIVP. We anticipate that the goodwill associated with this acquisition will be deductible for tax purposes.

Collaborations and Other Arrangements (Details) - USD ($)
$ in Millions

1 Months Ended

3 Months Ended

12 Months Ended

Sep. 30, 2014

Oct. 31, 2013

Dec. 31, 2009

Jun. 30, 2001

Mar. 31, 2017

Jun. 30, 2016

Mar. 31, 2016

Dec. 31, 2015

Mar. 31, 2015

Dec. 31, 2016

$ 240.4

$ 182.3

Nonoperating Income (Expense)

5,228.3

4,865.1

Research and development

1,238.3

1,221.0

15.1

(149.0)

Marketing, selling, and administrative

1,544.7

1,473.9

Sales [Member] | Erbitux [Member]

857.6

0.0

Collaborative Arrangement, Rights and Obligations Percent

38.00%

Profit and Development and Marketing Share [Member] | Effient [Member]

Collaborative Arrangement, Rights and Obligations Percent

50.00%

Research and Development Exp [Member] | Olumiant [Member]

Collaborative Arrangement, Rights and Obligations Percent

30.00%

Milestone Payments, Development and Regulatory, Capitalized [Member] | Lly Compounds [Member]

Collaborative Arrangement, Rights and Obligations, Terms

^[1]

0.0

$ 187.5

Milestone Payments, Development and Regulatory, Capitalized [Member] | Trajenta (BI) [Member]

Collaborative Arrangement, Rights and Obligations, Terms

^[1],[2]

0.0

Milestone Payments, Development and Regulatory, Capitalized [Member] | Jardiance (BI) [Member]

Collaborative Arrangement, Rights and Obligations, Terms

^[1],[3]

0.0

$ 0.0

Milestone Payments, Development and Regulatory, Capitalized [Member] | Olumiant [Member]

Collaborative Arrangement, Rights and Obligations, Terms

(65.0)

Milestone Payments, Development and Regulatory, Capitalized, Cumulative [Member] | Lly Compounds [Member]

Collaborative Arrangement, Rights and Obligations, Terms

^[1],[4]

250.0

Milestone Payments, Development and Regulatory, Capitalized, Cumulative [Member] | Trajenta (BI) [Member]

Collaborative Arrangement, Rights and Obligations, Terms

^[1],[2],[4]

(446.4)

Milestone Payments, Development and Regulatory, Capitalized, Cumulative [Member] | Jardiance (BI) [Member]

Collaborative Arrangement, Rights and Obligations, Terms

^[1],[3],[4]

(299.5)

Milestone Payments, Development and Regulatory, Expensed [Member] | Olumiant [Member]

Research and development

55.0

Milestone Payments, Sales-based [Member] | Olumiant [Member]

Collaborative Arrangement, Rights and Obligations, Terms

$ (150.0)

Milestone Payments, Sales-based [Member] | Tanezumab [Member]

Collaborative Arrangement, Rights and Obligations, Terms

$ (1,230.0)

Milestone Payments, Development and Regulatory [Member] | Olumiant [Member]

Collaborative Arrangement, Rights and Obligations, Terms

(295.0)

Milestone Payments, Development and Regulatory [Member] | Tanezumab [Member]

Collaborative Arrangement, Rights and Obligations, Terms

$ (350.0)

Milestone Payments, Development and Regulatory [Member] | Lanabecestat [Member]

Research and development

$ 100.0

Collaborative Arrangement, Rights and Obligations, Terms

$ (350.0)

Milestone Payments, Development and Regulatory, First Indication [Member] | Olumiant [Member]

Collaborative Arrangement, Rights and Obligations, Terms

$ (115.0)

Royalty Agreement Terms [Member] | Olumiant [Member]

Collaborative Arrangement, Rights and Obligations Percent

20.00%

Upfront Payment [Member] | Tanezumab [Member]

Collaborative Arrangement [Member]

$ 200.0

Marketing, selling, and administrative

46.7

49.0

Human Pharmaceutical Products [Member]

Human Pharmaceutical Products [Member] | Lly Compounds [Member]

4,459.0

4,110.5

Human Pharmaceutical Products [Member] | Erbitux [Member]

46.0

10.9

23.1

26.6

Sales Revenue, Goods, Net

154.4

168.1

131.3

141.5

Human Pharmaceutical Products [Member] | Effient [Member]

Human Pharmaceutical Products [Member] | Trajenta (BI) [Member]

127.8

131.5

Human Pharmaceutical Products [Member] | Jardiance (BI) [Member]

113.0

94.4

Transfer of Financial Assets Accounted for as Sales, Amount Derecognized

$ 74.0

$ 38.2

[1]	(1) In connection with the regulatory approvals of Basaglar in the U.S., Europe, and Japan, milestone payments received were recorded as deferred revenue and are being amortized through the term of the collaboration (2029) to collaboration and other revenue. In connection with the regulatory approvals of Trajenta and Jardiance, milestone payments made were capitalized as intangible assets and are being amortized to cost of sales.
[2]	(2) Jentadueto is included in the Trajenta family of product results.
[3]	(3) Glyxambi and Synjardy are included in the Jardiance family of product results.
[4]	(4) The cumulative amount represents the total initial amounts that were (deferred) or capitalized from the start of this collaboration through the end of the reporting period.

Asset Impairment, Restructuring, and Other Special Charges (Details) - USD ($) $ in Millions	3 Months Ended
	Mar. 31, 2017	Mar. 31, 2016
Restructuring Cost and Reserve [Line Items]
Severance Costs	$ 168.7	$ 9.5
Asset impairment, restructuring, and other special charges	213.9	131.4
Human Pharmaceutical Products [Member]
Restructuring Cost and Reserve [Line Items]
Severance Costs	113.1	0.0
Animal Health [Member]
Restructuring Cost and Reserve [Line Items]
Severance Costs	55.6	9.5
Asset Impairment Charges	$ 45.2	121.9
IRELAND \| Animal Health [Member]
Restructuring Cost and Reserve [Line Items]
Asset Impairment Charges		$ 87.2

Financial Instruments (Details)
€ in Millions, ¥ in Millions, £ in Millions, $ in Millions

3 Months Ended

Mar. 31, 2017

USD ($)

Mar. 31, 2016

USD ($)

Mar. 31, 2017

EUR (€)

Mar. 31, 2017

GBP (£)

Mar. 31, 2017

USD ($)

Mar. 31, 2017

JPY (¥)

Dec. 31, 2016

USD ($)

$ 652.0

$ 661.6

Interest Expense

$ 46.6

$ 43.4

Available-for-sale Debt Securities, Accumulated Gross Unrealized Gain, before Tax

280.5

352.6

Available-for-sale Debt Securities, Accumulated Gross Unrealized Loss, before Tax

24.6

34.1

Available-for-sale Securities, Gross Realized Gains

51.7

1.8

Repayments of Long-term Debt

$ 630.2

0.0

Available-for-sale Securities, Debt Securities

$ 5,118.5

Available-for-sale, Securities in Unrealized Loss Positions, Qualitative Disclosure, Other, Percentage of Nonperforming Assets

95.00%

Maximum Remaining Maturity of Foreign Currency Derivatives

30 days

Description of Derivative Activity Volume Percent

25.00%

Interest Rate Cash Flow Hedge Gain (Loss) to be Reclassified During Next 12 Months, Net

$ 15.1

Business Combination, Contingent Consideration Arrangements, Change in Amount of Contingent Consideration, Liability

$ 49.9

Available-for-sale Securities, Debt Maturities, Year Two Through Five, Fair Value

3,871.7

Available-for-sale Securities, Continuous Unrealized Gain Position, Fair Value

2,173.7

1,869.7

Available-for-sale Securities, Continuous Unrealized Loss Position, Fair Value

3,030.5

3,262.3

Other than Temporary Impairment Losses, Investments

0.0

25.7

Proceeds from Sale and Maturity of Available-for-sale Securities

1,092.5

726.4

Available-for-sale Securities, Gross Realized Losses

1.3

7.3

Available-for-sale Securities, Noncurrent [Abstract]

Available-for-sale Securities, Debt Maturities, Next Twelve Months, Fair Value

886.6

Available-for-sale Securities, Debt Maturities, Year Six Through Ten, Fair Value

151.2

Available-for-sale Securities, Debt Maturities, after Ten Years, Fair Value

209.0

Investment Income, Interest

32.6

24.2

Foreign Currency Transaction Gain (Loss), Realized

0.0

(203.9)

Other Nonoperating Income (Expense)

29.1

74.1

Nonoperating Income (Expense)

15.1

(149.0)

Net Investment Hedging [Member]

Derivative Instruments, Gain (Loss) Recognized in Other Comprehensive Income (Loss), Effective Portion, Net

(78.9)

(77.8)

Foreign Currency Denominated Debt [Member]

Cross Currency Interest Rate Contract [Member] | Net Investment Hedging [Member]

(3,420.0)

(3,340.0)

Derivative Instruments, Gain (Loss) Recognized in Other Comprehensive Income (Loss), Effective Portion, Net

(6.0)

(1.2)

Buy British pound Sell euro [Member]

Available-for-sale Securities, Noncurrent [Abstract]

Derivative Liability, Notional Amount | £

£ 269.3

Derivative Asset, Notional Amount | €

€ 310.1

Buy US dollar Sell euro [Member]

Available-for-sale Securities, Noncurrent [Abstract]

Derivative Liability, Notional Amount

4,160.0

Derivative Asset, Notional Amount | €

3,890.0

Buy euro Sell US dollar [Member]

Available-for-sale Securities, Noncurrent [Abstract]

Derivative Liability, Notional Amount | €

€ 3,470.0

Derivative Asset, Notional Amount

3,750.0

Buy US dollar Sell Japanese Yen [Member]

Available-for-sale Securities, Noncurrent [Abstract]

Derivative Liability, Notional Amount

587.1

Derivative Asset, Notional Amount | ¥

¥ 65,960

Buy US dollar Sell British pound [Member]

Available-for-sale Securities, Noncurrent [Abstract]

Derivative Liability, Notional Amount

224.4

Derivative Asset, Notional Amount | £

£ 180.6

Hedged Fixed Rate Debt [Member] | Designated as Hedging Instrument [Member]

Change in Unrealized Gain (Loss) on Hedged Item in Fair Value Hedge

(7.5)

75.3

Interest Rate Contract [Member] | Designated as Hedging Instrument [Member]

Change in Unrealized Gain (Loss) on Fair Value Hedging Instruments

7.5

(75.3)

Derivative Instruments, Loss Reclassified from Accumulated OCI into Income, Effective Portion

3.8

3.7

Foreign Exchange Contract [Member] | Not Designated as Hedging Instrument [Member]

Gain (Loss) on Foreign Currency Derivative Instruments Not Designated as Hedging Instruments

$ 37.2

$ 13.3

Estimate of Fair Value Measurement [Member]

(1,798.8)

(1,299.3)

990.5

2,986.8

Estimate of Fair Value Measurement [Member] | Not Designated as Hedging Instrument [Member]

(8,760.8)

(9,419.1)

Business Combination, Contingent Consideration, Liability, Current

^[1]

(213.8)

(215.9)

Business Combination, Contingent Consideration, Liability, Noncurrent

^[1]

(189.4)

(242.6)

Estimate of Fair Value Measurement [Member] | Fair Value, Inputs, Level 1 [Member]

0.0

916.8

2,699.4

Estimate of Fair Value Measurement [Member] | Fair Value, Inputs, Level 1 [Member] | Not Designated as Hedging Instrument [Member]

0.0

Business Combination, Contingent Consideration, Liability, Current

^[1]

0.0

Business Combination, Contingent Consideration, Liability, Noncurrent

^[1]

0.0

Estimate of Fair Value Measurement [Member] | Fair Value, Inputs, Level 2 [Member]

(1,798.8)

(1,299.3)

73.7

287.4

Estimate of Fair Value Measurement [Member] | Fair Value, Inputs, Level 2 [Member] | Not Designated as Hedging Instrument [Member]

(8,760.8)

(9,419.1)

Business Combination, Contingent Consideration, Liability, Current

^[1]

0.0

Business Combination, Contingent Consideration, Liability, Noncurrent

^[1]

0.0

Estimate of Fair Value Measurement [Member] | Fair Value, Inputs, Level 3 [Member]

0.0

0.0

Estimate of Fair Value Measurement [Member] | Fair Value, Inputs, Level 3 [Member] | Not Designated as Hedging Instrument [Member]

0.0

Business Combination, Contingent Consideration, Liability, Current

^[1]

(213.8)

(215.9)

Business Combination, Contingent Consideration, Liability, Noncurrent

^[1]

(189.4)

(242.6)

Estimate of Fair Value Measurement [Member] | Corporate Debt Securities [Member]

Available-for-sale Securities, Current [Abstract]

Available-for-sale Securities, Debt Securities, Current

784.7

1,219.2

Available-for-sale Securities, Noncurrent [Abstract]

Available-for-sale Securities, Debt Securities, Noncurrent

3,188.0

3,062.2

Estimate of Fair Value Measurement [Member] | Corporate Debt Securities [Member] | Fair Value, Inputs, Level 1 [Member]

Available-for-sale Securities, Current [Abstract]

Available-for-sale Securities, Debt Securities, Current

0.0

Available-for-sale Securities, Noncurrent [Abstract]

Available-for-sale Securities, Debt Securities, Noncurrent

0.0

Estimate of Fair Value Measurement [Member] | Corporate Debt Securities [Member] | Fair Value, Inputs, Level 2 [Member]

Available-for-sale Securities, Current [Abstract]

Available-for-sale Securities, Debt Securities, Current

784.7

1,219.2

Available-for-sale Securities, Noncurrent [Abstract]

Available-for-sale Securities, Debt Securities, Noncurrent

3,188.0

3,062.2

Estimate of Fair Value Measurement [Member] | Corporate Debt Securities [Member] | Fair Value, Inputs, Level 3 [Member]

Available-for-sale Securities, Current [Abstract]

Available-for-sale Securities, Debt Securities, Current

0.0

Available-for-sale Securities, Noncurrent [Abstract]

Available-for-sale Securities, Debt Securities, Noncurrent

0.0

Estimate of Fair Value Measurement [Member] | US Government Agencies Debt Securities [Member]

Available-for-sale Securities, Current [Abstract]

Available-for-sale Securities, Debt Securities, Current

98.9

232.5

Available-for-sale Securities, Noncurrent [Abstract]

Available-for-sale Securities, Debt Securities, Noncurrent

359.1

318.9

Estimate of Fair Value Measurement [Member] | US Government Agencies Debt Securities [Member] | Fair Value, Inputs, Level 1 [Member]

Available-for-sale Securities, Current [Abstract]

Available-for-sale Securities, Debt Securities, Current

98.9

232.5

Available-for-sale Securities, Noncurrent [Abstract]

Available-for-sale Securities, Debt Securities, Noncurrent

359.1

318.9

Estimate of Fair Value Measurement [Member] | US Government Agencies Debt Securities [Member] | Fair Value, Inputs, Level 2 [Member]

Available-for-sale Securities, Current [Abstract]

Available-for-sale Securities, Debt Securities, Current

0.0

Available-for-sale Securities, Noncurrent [Abstract]

Available-for-sale Securities, Debt Securities, Noncurrent

0.0

Estimate of Fair Value Measurement [Member] | US Government Agencies Debt Securities [Member] | Fair Value, Inputs, Level 3 [Member]

Available-for-sale Securities, Current [Abstract]

Available-for-sale Securities, Debt Securities, Current

0.0

Available-for-sale Securities, Noncurrent [Abstract]

Available-for-sale Securities, Debt Securities, Noncurrent

0.0

Estimate of Fair Value Measurement [Member] | Other Debt Obligations [Member]

Available-for-sale Securities, Current [Abstract]

Available-for-sale Securities, Debt Securities, Current

2.1

0.5

Available-for-sale Securities, Noncurrent [Abstract]

Available-for-sale Securities, Debt Securities, Noncurrent

167.1

153.7

Estimate of Fair Value Measurement [Member] | Other Debt Obligations [Member] | Fair Value, Inputs, Level 1 [Member]

Available-for-sale Securities, Current [Abstract]

Available-for-sale Securities, Debt Securities, Current

0.0

Available-for-sale Securities, Noncurrent [Abstract]

Available-for-sale Securities, Debt Securities, Noncurrent

0.0

Estimate of Fair Value Measurement [Member] | Other Debt Obligations [Member] | Fair Value, Inputs, Level 2 [Member]

Available-for-sale Securities, Current [Abstract]

Available-for-sale Securities, Debt Securities, Current

2.1

0.5

Available-for-sale Securities, Noncurrent [Abstract]

Available-for-sale Securities, Debt Securities, Noncurrent

0.0

Estimate of Fair Value Measurement [Member] | Other Debt Obligations [Member] | Fair Value, Inputs, Level 3 [Member]

Available-for-sale Securities, Current [Abstract]

Available-for-sale Securities, Debt Securities, Current

0.0

Available-for-sale Securities, Noncurrent [Abstract]

Available-for-sale Securities, Debt Securities, Noncurrent

167.1

153.7

Estimate of Fair Value Measurement [Member] | Collateralized Mortgage Backed Securities [Member]

Available-for-sale Securities, Noncurrent [Abstract]

Available-for-sale Securities, Debt Securities, Noncurrent

171.5

183.1

Estimate of Fair Value Measurement [Member] | Collateralized Mortgage Backed Securities [Member] | Fair Value, Inputs, Level 1 [Member]

Available-for-sale Securities, Noncurrent [Abstract]

Available-for-sale Securities, Debt Securities, Noncurrent

0.0

Estimate of Fair Value Measurement [Member] | Collateralized Mortgage Backed Securities [Member] | Fair Value, Inputs, Level 2 [Member]

Available-for-sale Securities, Noncurrent [Abstract]

Available-for-sale Securities, Debt Securities, Noncurrent

171.5

183.1

Estimate of Fair Value Measurement [Member] | Collateralized Mortgage Backed Securities [Member] | Fair Value, Inputs, Level 3 [Member]

Available-for-sale Securities, Noncurrent [Abstract]

Available-for-sale Securities, Debt Securities, Noncurrent

0.0

Estimate of Fair Value Measurement [Member] | Asset-backed Securities [Member]

Available-for-sale Securities, Current [Abstract]

Available-for-sale Securities, Debt Securities, Current

3.0

4.3

Available-for-sale Securities, Noncurrent [Abstract]

Available-for-sale Securities, Debt Securities, Noncurrent

513.4

502.7

Estimate of Fair Value Measurement [Member] | Asset-backed Securities [Member] | Fair Value, Inputs, Level 1 [Member]

Available-for-sale Securities, Current [Abstract]

Available-for-sale Securities, Debt Securities, Current

0.0

Available-for-sale Securities, Noncurrent [Abstract]

Available-for-sale Securities, Debt Securities, Noncurrent

0.0

Estimate of Fair Value Measurement [Member] | Asset-backed Securities [Member] | Fair Value, Inputs, Level 2 [Member]

Available-for-sale Securities, Current [Abstract]

Available-for-sale Securities, Debt Securities, Current

3.0

4.3

Available-for-sale Securities, Noncurrent [Abstract]

Available-for-sale Securities, Debt Securities, Noncurrent

513.4

502.7

Estimate of Fair Value Measurement [Member] | Asset-backed Securities [Member] | Fair Value, Inputs, Level 3 [Member]

Available-for-sale Securities, Current [Abstract]

Available-for-sale Securities, Debt Securities, Current

0.0

Available-for-sale Securities, Noncurrent [Abstract]

Available-for-sale Securities, Debt Securities, Noncurrent

0.0

Estimate of Fair Value Measurement [Member] | Equity Securities, US [Member]

Available-for-sale Securities, Noncurrent [Abstract]

Available-for-sale Securities, Equity Securities, Noncurrent

340.1

418.2

Estimate of Fair Value Measurement [Member] | Equity Securities, US [Member] | Fair Value, Inputs, Level 1 [Member]

Available-for-sale Securities, Noncurrent [Abstract]

Available-for-sale Securities, Equity Securities, Noncurrent

340.1

418.2

Estimate of Fair Value Measurement [Member] | Equity Securities, US [Member] | Fair Value, Inputs, Level 2 [Member]

Available-for-sale Securities, Noncurrent [Abstract]

Available-for-sale Securities, Equity Securities, Noncurrent

0.0

Estimate of Fair Value Measurement [Member] | Equity Securities, US [Member] | Fair Value, Inputs, Level 3 [Member]

Available-for-sale Securities, Noncurrent [Abstract]

Available-for-sale Securities, Equity Securities, Noncurrent

0.0

Estimate of Fair Value Measurement [Member] | Cross Currency Interest Rate Contract [Member] | Designated as Hedging Instrument [Member]

5.3

Estimate of Fair Value Measurement [Member] | Cross Currency Interest Rate Contract [Member] | Fair Value, Inputs, Level 1 [Member] | Designated as Hedging Instrument [Member]

21.3

31.4

0.0

Estimate of Fair Value Measurement [Member] | Cross Currency Interest Rate Contract [Member] | Fair Value, Inputs, Level 2 [Member] | Designated as Hedging Instrument [Member]

0.0

5.3

Estimate of Fair Value Measurement [Member] | Cross Currency Interest Rate Contract [Member] | Fair Value, Inputs, Level 3 [Member] | Designated as Hedging Instrument [Member]

21.3

31.4

0.0

Estimate of Fair Value Measurement [Member] | Interest Rate Contract [Member] | Designated as Hedging Instrument [Member]

0.0

4.3

2.4

28.9

37.0

(0.4)

Estimate of Fair Value Measurement [Member] | Interest Rate Contract [Member] | Fair Value, Inputs, Level 1 [Member] | Designated as Hedging Instrument [Member]

(1.0)

(0.5)

0.0

0.0

0.0

Estimate of Fair Value Measurement [Member] | Interest Rate Contract [Member] | Fair Value, Inputs, Level 2 [Member] | Designated as Hedging Instrument [Member]

0.0

4.3

2.4

28.9

37.0

(0.4)

Estimate of Fair Value Measurement [Member] | Interest Rate Contract [Member] | Fair Value, Inputs, Level 3 [Member] | Designated as Hedging Instrument [Member]

(1.0)

(0.5)

0.0

0.0

0.0

Estimate of Fair Value Measurement [Member] | Foreign Exchange Contract [Member] | Not Designated as Hedging Instrument [Member]

0.0

8.2

31.8

Estimate of Fair Value Measurement [Member] | Foreign Exchange Contract [Member] | Fair Value, Inputs, Level 1 [Member] | Not Designated as Hedging Instrument [Member]

(49.5)

(21.7)

0.0

Estimate of Fair Value Measurement [Member] | Foreign Exchange Contract [Member] | Fair Value, Inputs, Level 2 [Member] | Not Designated as Hedging Instrument [Member]

0.0

8.2

31.8

Estimate of Fair Value Measurement [Member] | Foreign Exchange Contract [Member] | Fair Value, Inputs, Level 3 [Member] | Not Designated as Hedging Instrument [Member]

(49.5)

(21.7)

0.0

Reported Value Measurement [Member]

0.0

(1,799.7)

(1,299.3)

990.5

2,986.8

Available-for-sale Securities, Current [Abstract]

(8,447.1)

(9,005.9)

Available-for-sale Securities, Current, Total

888.7

1,456.5

Available-for-sale Securities, Noncurrent [Abstract]

Available-for-sale Securities, Noncurrent, Total

5,297.7

5,207.5

Reported Value Measurement [Member] | Not Designated as Hedging Instrument [Member]

Business Combination, Contingent Consideration, Liability, Current

^[1]

(213.8)

(215.9)

Business Combination, Contingent Consideration, Liability, Noncurrent

^[1]

(189.4)

(242.6)

Reported Value Measurement [Member] | Corporate Debt Securities [Member]

Available-for-sale Securities, Current [Abstract]

Available-for-sale Securities, Debt Securities, Current

784.7

1,219.2

Available-for-sale Securities, Noncurrent [Abstract]

Available-for-sale Securities, Debt Securities, Noncurrent

3,188.0

3,062.2

Reported Value Measurement [Member] | US Government Agencies Debt Securities [Member]

Available-for-sale Securities, Current [Abstract]

Available-for-sale Securities, Debt Securities, Current

98.9

232.5

Available-for-sale Securities, Noncurrent [Abstract]

Available-for-sale Securities, Debt Securities, Noncurrent

359.1

318.9

Reported Value Measurement [Member] | Other Debt Obligations [Member]

Available-for-sale Securities, Current [Abstract]

Available-for-sale Securities, Debt Securities, Current

2.1

0.5

Available-for-sale Securities, Noncurrent [Abstract]

Available-for-sale Securities, Debt Securities, Noncurrent

167.1

153.7

Reported Value Measurement [Member] | Collateralized Mortgage Backed Securities [Member]

Available-for-sale Securities, Noncurrent [Abstract]

Available-for-sale Securities, Debt Securities, Noncurrent

171.5

183.1

Reported Value Measurement [Member] | Asset-backed Securities [Member]

Available-for-sale Securities, Current [Abstract]

Available-for-sale Securities, Debt Securities, Current

3.0

4.3

Available-for-sale Securities, Noncurrent [Abstract]

Available-for-sale Securities, Debt Securities, Noncurrent

513.4

502.7

Reported Value Measurement [Member] | Equity Securities, US [Member]

Available-for-sale Securities, Noncurrent [Abstract]

Available-for-sale Securities, Equity Securities, Noncurrent

340.1

418.2

Reported Value Measurement [Member] | Equity Method and Other Investments [Member]

Available-for-sale Securities, Noncurrent [Abstract]

Other Long-term Investments

^[2]

558.5

568.7

Reported Value Measurement [Member] | Cross Currency Interest Rate Contract [Member] | Designated as Hedging Instrument [Member]

5.3

Reported Value Measurement [Member] | Interest Rate Contract [Member] | Designated as Hedging Instrument [Member]

21.3

31.4

4.3

2.4

28.9

37.0

(0.4)

Reported Value Measurement [Member] | Foreign Exchange Contract [Member] | Not Designated as Hedging Instrument [Member]

(1.0)

(0.5)

8.2

31.8

Portion at Other than Fair Value Measurement [Member]

(49.5)

(21.7)

Portion at Other than Fair Value Measurement [Member] | Corporate Debt Securities [Member]

^[3]

990.5

2,986.8

Available-for-sale Securities, Current [Abstract]

Available-for-sale Securities, Debt Securities, Current

^[3]

784.4

1,219.1

Available-for-sale Securities, Noncurrent [Abstract]

Available-for-sale Securities, Debt Securities, Noncurrent

^[3]

3,191.3

3,074.3

Portion at Other than Fair Value Measurement [Member] | US Government Agencies Debt Securities [Member]

Available-for-sale Securities, Current [Abstract]

Available-for-sale Securities, Debt Securities, Current

^[3]

99.0

232.6

Available-for-sale Securities, Noncurrent [Abstract]

Available-for-sale Securities, Debt Securities, Noncurrent

^[3]

363.2

323.8

Portion at Other than Fair Value Measurement [Member] | Other Debt Obligations [Member]

Available-for-sale Securities, Current [Abstract]

Available-for-sale Securities, Debt Securities, Current

^[3]

2.1

0.5

Available-for-sale Securities, Noncurrent [Abstract]

Available-for-sale Securities, Debt Securities, Noncurrent

^[3]

83.3

77.6

Portion at Other than Fair Value Measurement [Member] | Collateralized Mortgage Backed Securities [Member]

Available-for-sale Securities, Noncurrent [Abstract]

Available-for-sale Securities, Debt Securities, Noncurrent

^[3]

173.6

185.4

Portion at Other than Fair Value Measurement [Member] | Asset-backed Securities [Member]

Available-for-sale Securities, Current [Abstract]

Available-for-sale Securities, Debt Securities, Current

^[3]

3.0

4.3

Available-for-sale Securities, Noncurrent [Abstract]

Available-for-sale Securities, Debt Securities, Noncurrent

^[3]

514.3

503.5

Portion at Other than Fair Value Measurement [Member] | Equity Securities, US [Member]

Available-for-sale Securities, Noncurrent [Abstract]

Available-for-sale Securities, Equity Securities, Noncurrent

^[3]

$ 78.3

$ 91.9

[1]	(1) Contingent consideration liabilities primarily relate to the Erbitux arrangement with BMS discussed in Note 4.
[2]	(2) Fair value disclosures are not applicable for cost method and equity method investments.
[3]	(1) For available-for-sale debt securities, amounts disclosed represent the securities' amortized cost.

Shareholders' Equity (Details) - USD ($) $ in Millions	3 Months Ended
Shareholders' Equity (Details) - USD ($) $ in Millions	Mar. 31, 2017	Dec. 31, 2016	Mar. 31, 2016	Oct. 31, 2013
Stockholders' Equity Note [Abstract]
Treasury Stock, Value, Acquired, Cost Method	$ 60.0		$ 300.1
Stock Repurchase Program, Authorized Amount				$ 5,000.0
Stock Repurchase Program, Remaining Authorized Repurchase Amount	2,350.0
Payments for Repurchase of Common Stock	$ 0.0	$ 60.0	$ 300.1

Income Taxes Income Taxes (Details) - USD ($) $ in Millions	3 Months Ended		12 Months Ended
Income Taxes Income Taxes (Details) - USD ($) $ in Millions	Mar. 31, 2017	Mar. 31, 2016	Dec. 31, 2016	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013	Dec. 31, 2012	Dec. 31, 2011	Dec. 31, 2010
Income Tax Examination [Line Items]
Income taxes	$ 172.0	$ 126.7
Income Tax Examination, Year under Examination				2015	2014	2013	2012	2011	2010
Decrease in Unrecognized Tax Benefits is Reasonably Possible		140.0
Income Taxes Paid			$ 150.0
Income before income taxes	61.2	566.8
Acquired in-process research and development	857.6	$ 0.0
CoLucid Pharmaceuticals [Member]
Income Tax Examination [Line Items]
Acquired in-process research and development	$ 857.6

Retirement Benefits (Details) - USD ($) $ in Millions	3 Months Ended
Retirement Benefits (Details) - USD ($) $ in Millions	Mar. 31, 2017	Mar. 31, 2016
Pension Contributions	$ 15.0
Defined Benefit Plan, Estimated Future Employer Contributions in Current Fiscal Year	35.0
Pension Plans, Defined Benefit [Member]
Defined Benefit Plan, Service Cost	78.9	$ 71.3
Defined Benefit Plan, Interest Cost	102.4	105.1
Defined Benefit Plan, Expected Return on Plan Assets	(194.0)	(189.6)
Defined Benefit Plan, Amortization of Prior Service Cost (Credit)	1.4	6.0
Defined Benefit Plan, Actuarial Gain (Loss)	72.7	68.3
Defined Benefit Plan, Net Periodic Benefit Cost, Total	61.4	61.1
Other Postretirement Benefit Plans, Defined Benefit [Member]
Defined Benefit Plan, Service Cost	11.2	9.3
Defined Benefit Plan, Interest Cost	13.0	12.8
Defined Benefit Plan, Expected Return on Plan Assets	(40.3)	(37.5)
Defined Benefit Plan, Amortization of Prior Service Cost (Credit)	(22.5)	(21.4)
Defined Benefit Plan, Actuarial Gain (Loss)	4.1	5.2
Defined Benefit Plan, Net Periodic Benefit Cost, Total	$ (34.5)	$ (31.6)

Contingencies (Details) $ in Millions, R$ in Billions	1 Months Ended	3 Months Ended
Contingencies (Details) $ in Millions, R$ in Billions	Apr. 30, 2015 USD ($)	Mar. 31, 2017 BRL (R$)	Mar. 31, 2017 USD ($)
Product Liability Litigation [Member] \| Cymbalta [Member]
Loss Contingency, Number of Lawsuits		140	140
Loss Contingency, Number of Plaintiffs		1,470	1,470
Product Liability Litigation [Member] \| Actos [Member]
Loss Contingency, Number of Cases		6,500	6,500
Product Liability Litigation [Member] \| CANADA \| Actos [Member]
Loss Contingency, Number of Cases		3	3
Product Liability Litigation [Member] \| ONTARIO \| Actos [Member]
Loss Contingency, Number of Cases		1	1
Product Liability Litigation [Member] \| QUEBEC \| Actos [Member]
Loss Contingency, Number of Cases		1	1
Product Liability Litigation [Member] \| ALBERTA \| Actos [Member]
Loss Contingency, Number of Cases		1	1
Product Liability Litigation [Member] \| CALIFORNIA \| Cymbalta [Member]
Loss Contingency, Number of Lawsuits		40	40
Takeda Portion [Member] \| Product Liability Litigation [Member] \| Actos [Member]
Litigation Settlement, Amount	$ 2,400
Employee Litigation [Member] \| Brazil [Member]
Loss Contingency, Number of Lawsuits		30	30
Loss Contingency, Damages Awarded, Value		R$ 1.0	$ 315

Other Comprehensive Income (Loss) Other Comprehensive Income (Loss) (Details) - USD ($)
$ in Millions

3 Months Ended

Mar. 31, 2017

Mar. 31, 2016

Dec. 31, 2016

Dec. 31, 2015

^[5]

Other Comprehensive Income (Loss), Foreign Currency Transaction and Translation Adjustment, Net of Tax

$ (74.5)

Other Comprehensive Income (Loss), Foreign Currency Translation Adjustment, Tax

29.7

$ 27.7

Other Comprehensive Income (Loss), Pension and Other Postretirement Benefit Plans, Net Prior Service Cost Arising During Period, before Tax

^[1]

(21.1)

(15.4)

Other Comprehensive Income (Loss), Foreign Currency Transaction and Translation Reclassification Adjustment Realized upon Sale or Liquidation, Net of Tax

(5,064.3)

$ (5,274.0)

8.8

115.6

Other Comprehensive Income (Loss), Reclassification, Pension and Other Postretirement Benefit Plans, Net Gain (Loss) Recognized in Net Periodic Benefit Cost, before Tax

^[2]

198.7

316.0

^[1]

76.8

73.5

Other Comprehensive (Income) Loss, Reclassification Adjustment from AOCI, Pension and Other Postretirement Benefit Plans, before Tax

55.7

58.1

Other Comprehensive (Income) Loss, Reclassification Adjustment from AOCI, Pension and Other Postretirement Benefit Plans, for Net (Gain) Loss, Tax

(16.6)

(23.0)

Other Comprehensive (Income) Loss, Reclassification Adjustment from AOCI, Pension and Other Postretirement Benefit Plans, for Net (Gain) Loss, Net of Tax

39.1

35.1

Other Comprehensive Income (Loss), Reclassification Adjustment from AOCI for Sale of Securities, before Tax

(50.4)

5.5

Other Comprehensive Income (Loss), Reclassification Adjustment from AOCI for Sale of Securities, Tax

17.6

(1.9)

Other Comprehensive Income (Loss), Reclassification Adjustment from AOCI for Sale of Securities, Net of Tax

(32.8)

3.6

Other Comprehensive Income (Loss), Unrealized Holding Gain (Loss) on Securities Arising During Period, Tax

18.1

(4.2)

Other Comprehensive (Income) Loss, Pension and Other Postretirement Benefit Plans, before Reclassification Adjustments, Tax

(8.5)

(25.7)

Other Comprehensive Income, Other, Net of Tax

2.5

76.9

^[3]

Other Comprehensive Income (Loss), Unrealized Gain (Loss) on Derivatives Arising During Period, Tax

(1.3)

Other Comprehensive Income (Loss), Tax

38.0

(3.5)

AOCI Including Portion Attributable to Noncontrolling Interest [Member]

Other Comprehensive Income (Loss), Foreign Currency Transaction and Translation Gain (Loss) Arising During Period, Net of Tax

(5,027.1)

^[4]

(4,264.7)

^[4]

(5,225.8)

^[5]

$ (4,580.7)

189.9

200.4

Other Comprehensive Income (Loss), Foreign Currency Transaction and Translation Reclassification Adjustment Realized upon Sale or Liquidation, Net of Tax

8.8

115.6

Accumulated Net Gain (Loss) from Designated or Qualifying Cash Flow Hedges [Member]

198.7

316.0

Other Comprehensive Income (Loss), Foreign Currency Transaction and Translation Gain (Loss) Arising During Period, Net of Tax

(208.4)

^[4]

(216.1)

^[4]

(210.9)

^[5]

(218.5)

0.0

Other Comprehensive Income (Loss), Foreign Currency Transaction and Translation Reclassification Adjustment Realized upon Sale or Liquidation, Net of Tax

2.5

2.4

Accumulated Defined Benefit Plans Adjustment [Member]

2.5

2.4

Other Comprehensive Income (Loss), Foreign Currency Transaction and Translation Gain (Loss) Arising During Period, Net of Tax

(3,349.4)

^[4]

(2,981.1)

^[4]

(3,371.6)

^[5]

(3,012.1)

(16.9)

(4.1)

Other Comprehensive Income (Loss), Foreign Currency Transaction and Translation Reclassification Adjustment Realized upon Sale or Liquidation, Net of Tax

39.1

35.1

Accumulated Net Investment Gain (Loss) Including Portion Attributable to Noncontrolling Interest [Member]

22.2

31.0

Other Comprehensive Income (Loss), Foreign Currency Transaction and Translation Gain (Loss) Arising During Period, Net of Tax

179.4

^[4]

17.9

^[4]

224.0

^[5]

10.1

(11.8)

4.2

Other Comprehensive Income (Loss), Foreign Currency Transaction and Translation Reclassification Adjustment Realized upon Sale or Liquidation, Net of Tax

(32.8)

3.6

Accumulated Translation Adjustment [Member]

(44.6)

7.8

Other Comprehensive Income (Loss), Foreign Currency Transaction and Translation Gain (Loss) Arising During Period, Net of Tax

(1,648.7)

^[4]

(1,085.4)

^[4]

(1,867.3)

^[5]

$ (1,360.2)

218.6

200.3

Other Comprehensive Income (Loss), Foreign Currency Transaction and Translation Reclassification Adjustment Realized upon Sale or Liquidation, Net of Tax

0.0

74.5

AOCI Attributable to Noncontrolling Interest [Member]

218.6

$ 274.8

AOCI Attributable to Parent [Member]

37.2

48.2