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UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
SCHEDULE 13G
Under the Securities Exchange Act of 1934
(Amendment No. 2)*
Check the appropriate box to designate the rule pursuant to which this Schedule is filed:
o Rule 13d-1(b)
þ Rule 13d-1(c)
o Rule 13d-1(d)
* The remainder of this cover page shall be filled out for a reporting person’s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page.
The information required in the remainder of this cover page shall not be deemed to be “filed” for the purpose of Section 18 of the Securities Exchange Act of 1934 (“Act”) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB control number.
CUSIP No. |
464330-1-09 |
Page | 2 |
of | 5 |
| 1 | NAMES OF REPORTING PERSONS: Eli Lilly and Company |
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| I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY): | |||||
| 35-0470950 | |||||
| 2 | CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS): |
||||
| (a) o | |||||
| (b) o Not Applicable | |||||
| 3 | SEC USE ONLY: | ||||
| 4 | CITIZENSHIP OR PLACE OF ORGANIZATION: | ||||
| Indiana | |||||
| 5 | SOLE VOTING POWER: | ||||
| NUMBER OF | 2,500,000 | ||||
| SHARES | 6 | SHARED VOTING POWER: | |||
| BENEFICIALLY | |||||
| OWNED BY | None | ||||
| EACH | 7 | SOLE DISPOSITIVE POWER: | |||
| REPORTING | |||||
| PERSON | 2,500,000 | ||||
| WITH: | 8 | SHARED DISPOSITIVE POWER: | |||
| None | |||||
| 9 | AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON: | ||||
| 2,500,000 | |||||
| 10 | CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS): | ||||
| o Not Applicable | |||||
| 11 | PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9): | ||||
| 3.5% | |||||
| 12 | TYPE OF REPORTING PERSON (SEE INSTRUCTIONS): | ||||
| CO | |||||
2
Item 1(a).
|
Name of Issuer: | |
| Isis Pharmaceuticals, Inc. | ||
Item 1(b).
|
Address of Issuer’s Principal | |
| Executive Offices: | ||
| 2292 Faraday Avenue | ||
| Carlsbad, CA 92008 | ||
Item 2(a).
|
Name of Person Filing: | |
| Eli Lilly and Company |
||
Item 2(b).
|
Address of Principal Business | |
| Office or, if None, Residence: | ||
| Lilly Corporate Center | ||
| Indianapolis, IN 46285 | ||
Item 2(c).
|
Citizenship: | |
| Indiana | ||
Item 2(d).
|
Title of Class of Securities: | |
| Common Stock | ||
Item 2(e).
|
CUSIP Number: | |
| 464330-1-09 | ||
Item 3.
|
If this statement is filed pursuant to Rule 13d-1(b), or 13d-2(b) or (c), check whether the person filing is a: | |
| (a)-(j) Not applicable | ||
| If this statement is filed pursuant to Rule 13d-1(c), check this box. [ X ] |
Page 3 of 5 Pages
Item 4.
|
Ownership. |
(a) |
Amount Beneficially Owned: |
|
| 2,500,000 |
||
(b) |
Percent of Class: |
|
| 3.5% |
||
(c) |
Number of shares as to which the person has: |
|
| Sole voting power
2,500,000 |
||
| Shared voting power
None |
||
| Sole dispositive power
2,500,000 |
||
| Shared dispositive power None |
Item 5.
|
Ownership of Five Percent or Less of a Class. [X] | |
Item 6.
|
Ownership of More Than Five Percent on Behalf of Another Person. | |
| Not applicable | ||
Item 7.
|
Identification and Classification of the Subsidiary which Acquired the Security Being Reported on by the Parent Holding Company. | |
| Not applicable | ||
Item 8.
|
Identification and Classification of Members of the Group. | |
| Not applicable | ||
Item 9.
|
Notice of Dissolution of Group. | |
| Not applicable |
Page 4 of 5 Pages
Item 10.
|
Certifications. | |
| By signing below, I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect. |
| ELI LILLY AND COMPANY |
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| By: | /s/ Charles E. Golden | |||
| Charles E. Golden | ||||
| Executive Vice President and Chief Financial Officer | ||||
Page 5 of 5 Pages