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                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                    FORM 10-K

                  ANNUAL REPORT PURSUANT TO SECTION 13 or 15(d)
                     OF THE SECURITIES EXCHANGE ACT OF 1934

                  For the fiscal year ended December 31, 1998

                        Commission File Number 001-6351


                             ELI LILLY AND COMPANY

            An Indiana Corporation I.R.S. Employer Number 35-0470950

          Address: Lilly Corporate Center, Indianapolis, Indiana 46285

             Telephone number, including area code: (317) 276-2000

          SECURITIES REGISTERED PURSUANT TO SECTION 12(b) OF THE ACT:

                                                Name Of Each Exchange
          Title Of Each Class                    On Which Registered
          -------------------                   ---------------------
             Common Stock                 New York and Pacific Stock Exchanges
     Preferred Stock Purchase Rights      New York and Pacific Stock Exchanges
  8-1/8% Notes Due December 1, 2001       New York Stock Exchange
  8-3/8% Notes Due December 1, 2006       New York Stock Exchange
    6.57% Notes Due January 1, 2016       New York Stock Exchange
    6.77% Notes Due January 1, 2036       New York Stock Exchange

        SECURITIES REGISTERED PURSUANT TO SECTION 12(g) OF THE ACT: None

Indicate by check mark whether the Registrant (1) has filed all reports required
to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during
the preceding 12 months, and (2) has been subject to such filing requirements
for the past 90 days. Yes X No ___

Indicate by check mark if disclosure of delinquent filers pursuant to Item 405
of Regulation S-K is not contained herein, and will not be contained, to the
best of Registrant's knowledge, in the definitive proxy statement incorporated
by reference in Part III of this Form 10-K or any amendment to this Form 10-K.
[ ]

Aggregate market value of voting stock of the Registrant held by non-affiliates
as of February 12, 1999 (Common Stock): $82,996,965,000.

Number of shares of common stock outstanding as of February 12, 1999:
1,101,256,334.

Portions of the following documents have been incorporated by reference into
this report:

                    Document                      Parts Into Which Incorporated
                    --------                      -----------------------------
Registrant's Annual Report to Shareholders              Parts I, II, and IV
    for fiscal year ended December 31, 1998

Registrant's Proxy Statement dated March 4, 1999               Part III

 
                                     PART I

Item 1.  BUSINESS

      Eli Lilly and Company was incorporated in 1901 under the laws of Indiana
to succeed to the drug manufacturing business founded in Indianapolis, Indiana,
in 1876 by Colonel Eli Lilly. The Company*, including its subsidiaries,
discovers, develops, manufactures, and sells products in one significant
business segment--pharmaceutical products. Products are manufactured or
distributed through owned or leased facilities in the United States, Puerto
Rico, and 27 other countries. Its products are sold in approximately 160
countries. Through its PCS Health Systems ("PCS") business, which was sold in
January 1999, the Company provided health care management services in the United
States. See "Health Care Management" at page 3.

      Most of the Company's products were discovered or developed through the
Company's research and development activities, and the success of the Company's
business depends to a great extent on the continued introduction of new products
resulting from these research and development activities. Research efforts are
primarily directed toward discovering and developing products to diagnose and
treat diseases in human beings and animals and to increase the efficiency of
animal food production.


                   FINANCIAL INFORMATION RELATING TO BUSINESS
                        SEGMENTS AND CLASSES OF PRODUCTS

      Financial information relating to business segments and classes of
products, set forth in the Company's 1998 Annual Report at page 43 under
"Segment Information" (page 6 of Exhibit 13 to this Form 10-K), is incorporated
herein by reference.

      Due to several factors, including the introduction of new products by the
Company and other manufacturers, the relative contribution of any particular
Company product to consolidated net sales is not necessarily constant from year
to year, and its contribution to net income is not necessarily the same as its
contribution to consolidated net sales.


                              PRODUCTS AND SERVICES

Pharmaceutical Products

    Pharmaceutical products include:

               Neuroscience products, the Company's largest-selling product
         group, including Prozac(R), indicated for the treatment of depression
         and, in many countries, for bulimia and obsessive-compulsive disorder;
         Zyprexa(R), a product for the treatment of schizophrenia; the Darvon(R)
         line of analgesic products; and Permax(R), a treatment for Parkinson's
         disease;

* The terms "Company" and "Registrant" are used interchangeably herein to refer
  to Eli Lilly and Company or to Eli Lilly and Company and its consolidated
  subsidiaries,  as the context requires.

                                      -1-

 
               Endocrine products, including Humulin(R), human insulin produced
         through recombinant DNA technology; Humalog(R), a rapid-acting
         injectable human insulin analog of recombinant DNA origin; Iletin(R),
         animal-source insulin in its various pharmaceutical forms; and
         Humatrope(R), human growth hormone produced by recombinant DNA
         technology;

               Anti-infectives, including the oral cephalosporin antibiotics
         Ceclor(R) (cefaclor), Keflex(R), and Keftab(R), used in the treatment
         of a wide range of bacterial infections; the oral carbacephem
         antibiotic Lorabid(R), used to treat a variety of bacterial infections;
         Vancocin(R) HCl, an injectable antibiotic used primarily to treat
         staphylococcal infections; the oral macrolide antibiotic Dynabac(R);
         the injectable cephalosporin antibiotics Tazidime(R), Kefurox(R), and
         Kefzol(R), used to treat a wide range of bacterial infections in the
         hospital setting; and Nebcin(R), an injectable aminoglycoside
         antibiotic used in hospitals to treat various infections caused by
         staphylococci and Gram-negative bacteria;

               Cardiovascular agents, including ReoPro(R), a monoclonal antibody
         product developed and manufactured by Centocor, Inc. and co-marketed by
         the Company and Centocor for use as an adjunct to percutaneous coronary
         intervention ("PCI"), including patients undergoing angioplasty,
         atherectomy or stent placement and patients with unstable angina who
         are not responding to conventional medical therapy when PCI is planned
         within 24 hours; Dobutrex(R), an inotropic agent; and Cynt(TM),
         marketed outside the United States for treatment of hypertension;

               An antiulcer agent, Axid(R), an H2 antagonist, indicated for the
         treatment of active duodenal ulcer, for maintenance therapy for
         duodenal ulcer patients after healing of an active duodenal ulcer, for
         reflux esophagitis, and for benign gastric ulcer;

               Oncology products, including Gemzar(R), indicated for treatment
         of advanced or metastatic pancreatic cancer and, in combination with
         other agents, for treatment of non-small-cell lung cancer; Oncovin(R),
         indicated for treatment of acute leukemia and, in combination with
         other oncolytic agents, for treatment of several different types of
         advanced cancers; Velban(R), used in a variety of malignant neoplastic
         conditions; and Eldisine(R), indicated for treatment of acute childhood
         leukemia resistant to other drugs; and

               Evista(R), a selective estrogen receptor modulator, indicated for
         the prevention of osteoporosis in post-menopausal women, and in some
         countries outside the United States, for the treatment of osteoporosis
         in post-menopausal women.

Animal Health Products

      Animal health products include Tylan(R), an antibiotic used to control
certain diseases in cattle, swine, and poultry and to improve feed efficiency
and growth; Rumensin(R), a cattle feed additive that improves feed efficiency
and growth; Coban(R), Monteban(R) and Maxiban(R), anticoccidial agents for use
in poultry; Apralan(R), an antibiotic used to control enteric infections in
calves and swine; Micotil(R) and Pulmotil(R), antibiotics used to treat
respiratory disease in cattle and swine, respectively; and Surmax(R) (sold as
Maxus(R) in some countries), a growth promotant for swine and poultry.

                                      -2-

 
Health Care Management Services

      The Company's PCS business was sold to Rite Aid Corporation effective
January 22, 1999. The Company received approximately $1.6 billion, including
$1.5 billion in cash from Rite Aid and approximately $100 million in cash from
PCS. As a result of the sale, the operating results of PCS are included in the
Company's 1998 financial statements as discontinued operations. PCS provided
computer-based prescription drug claims processing, pharmacy benefit
administration and management services, mail order pharmacy services, data
management and disease-management services to health plan sponsors, including
insurance companies, third-party administrators, self-insured employers, health
maintenance organizations, and Blue Cross/Blue Shield organizations that
underwrite or administer prescription benefit plans.

                                    MARKETING

      Most of the Company's major products are marketed worldwide. Health care
management services were marketed primarily in the United States.

Pharmaceuticals -- United States

      In the United States, the Company distributes pharmaceutical products
principally through approximately 200 independent wholesale distributing
outlets. The Company's marketing policy is designed to assure that products are
immediately available to physicians, pharmacies, hospitals, and appropriate
health care professionals throughout the country. Four wholesale distributors in
the United States accounted for approximately 17%, 15%, 13%, and 10%,
respectively, of the Company's consolidated net sales in 1998. No other
distributor accounted for more than 7% of consolidated net sales. The Company
also sells pharmaceutical products directly to the United States government and
other manufacturers, but those direct sales are not material to consolidated net
sales.

      The Company's major pharmaceutical products are promoted in the United
States under the Lilly and Dista trade names by Company sales forces employing
salaried sales representatives. These sales representatives, many of whom are
registered pharmacists, call upon physicians, wholesalers, hospitals,
managed-care organizations, retail pharmacists, and other health care
professionals. Their efforts are supported by the Company through advertising in
medical and drug journals, distribution of literature and samples of certain
products to physicians, and exhibits for use at medical meetings. The Company
also advertises certain of its products directly to consumers in the United
States. The Company has created divisions of its sales force dedicated to
product lines or practice areas, such as primary care, neuroscience, diabetes
care, cardiovascular, endocrinology, and oncology. The Company has entered into
licensing arrangements under which certain products manufactured by the Company,
such as Ceclor CD, Dynabac, Keftab, and Permax, are marketed by other
pharmaceutical companies.

      Large purchasers of pharmaceuticals, such as managed-care groups and
government and long-term care institutions, now account for a significant
portion of total pharmaceutical purchases in the United States. The Company has
created special sales groups to service managed-care organizations, government
and long-term care institutions, hospital contract administrators, and certain
retail pharmacies. In response to competitive pressures, the Company has entered
into arrangements with a number of these organizations providing for discounts
or rebates on one or more Company products or other cost-sharing arrangements.

                                      -3-

 
Pharmaceuticals -- Outside the United States

      Outside the United States, pharmaceutical products are promoted primarily
by salaried sales representatives. While the products marketed vary from country
to country, neuroscience products constitute the largest single group in total
sales. Distribution patterns vary from country to country. In recent years, the
Company has significantly expanded its marketing efforts in a number of overseas
markets, including emerging markets in Central and Eastern Europe, Latin
America, Asia and Africa.

Animal Health Products

      Elanco Animal Health, a division of the Company, employs field salespeople
throughout the United States to market animal health products. Sales are made to
wholesale distributors, retailers, feed manufacturers, or producers in
conformance with varying distribution patterns applicable to the various types
of products. The Company also has an extensive sales force outside the United
States to market its animal health products.

                                  RAW MATERIALS

      Most of the principal materials used by the Company in manufacturing
operations are chemical, plant, and animal products that are available from more
than one source. Certain raw materials are available or are purchased
principally from only one source. Unavailability of certain materials from
present sources could cause an interruption in production pending establishment
of new sources or, in some cases, implementation of alternative processes.

      Although the major portion of the Company's sales abroad are of products
manufactured wholly or in part abroad, a principal source of active ingredients
for these manufactured products continues to be the Company's facilities in the
United States.

                 PATENTS AND OTHER INTELLECTUAL PROPERTY RIGHTS

      Intellectual property protection is, in the aggregate, material to the
Company's ability to successfully commercialize its life sciences innovations.
The Company owns, has applications pending for, or is licensed under, a
substantial number of patents, both in the United States and in other countries,
relating to products, product uses, formulations, and manufacturing processes.
There can be no assurance that patents will result from the Company's pending
applications. Moreover, patents relating to particular products, uses,
formulations, or processes do not preclude other manufacturers from employing
alternative processes or from successfully marketing substitute products to
compete with the patented products or uses.

      The standard of intellectual property protection outside the United States
for pharmaceutical inventions varies widely. While many countries have strong
laws, many other countries provide little or no intellectual property
protection. In recent years, the adoption of international agreements such as
the new World Trade Agreement have resulted in a strengthening of intellectual
property laws in some countries, and the Company believes further improvements
are likely. The commercial significance of these changes to the Company is still
uncertain.

      The expiration of a product patent often results in a loss of market
exclusivity and, particularly in the United States, can result in very
substantial reductions in sales of the patented product. However, in some cases
additional commercial benefits may be obtained from

                                      -4-

 
manufacturing trade secrets, later-expiring patents on processes, uses, or
formulations, or marketing exclusivity that may be provided by the
pharmaceutical regulatory laws in the United States or other countries.

      Patent protection for certain products, processes, and uses--particularly
that relating to Prozac, Zyprexa, Axid, Humalog, ReoPro, Gemzar, and Evista--is
considered to be important to the operations of the Company. The United States
compound patent covering Prozac expires in February 2001 and a patent for the
process by which Prozac works expires in December 2003. See "Legal Proceedings"
at pages 10-11 for a discussion of certain litigation involving these two
patents. In other countries, Prozac patents generally either have expired or
will expire over the next several years. Other U.S. compound patent expirations
include Axid, 2002; Zyprexa, 2011; Humalog, 2013; and ReoPro, 2015. The Gemzar
compound patent in the U.S. expires in 2006, but a use patent covering treatment
of neoplasms with Gemzar is in force until 2012. The Company holds a number of
U.S. patents covering Evista that the Company believes will provide exclusivity
in the United States until at least 2012.

      Worldwide, all of the Company's major products are sold under trademarks
that are considered in the aggregate to be important to the Company. Trademark
protection varies widely throughout the world, with protection continuing in
some countries as long as the mark is used, and in other countries as long as it
is registered. Registrations are normally for fixed but renewable terms.

      The Company also grants licenses under patents and know-how developed by
the Company and manufactures and sells products and uses technology and know-how
under licenses from others. Royalties paid by the Company in relation to
pharmaceuticals amounted to approximately $138 million in 1998 and royalties
received were not material.

                                   COMPETITION

      The Company's pharmaceutical products compete with products manufactured
by many other companies in highly competitive markets in the United States and
throughout the world. The Company's animal health products compete on a
worldwide basis with products of pharmaceutical, chemical, and other companies
that operate animal health divisions or subsidiaries.

      Important competitive factors include product efficacy, safety and ease of
use, price and demonstrated cost-effectiveness, service, and research and
development of new products and processes. The introduction by competitors of
new products and processes with therapeutic or cost advantages can result in
progressive price reductions or decreased volume of sales of the Company's
products, or both. New products introduced with patent protection usually must
compete with other products already on the market at the time of introduction or
products developed by competitors after introduction. Manufacturers of generic
products typically invest far less in research and development than
research-based pharmaceutical companies and accordingly are able to price their
products significantly lower than branded products. Therefore, upon expiration
of market exclusivity, branded products often face intense price competition
from generic forms of the product. In many countries outside the United States,
patent protection is weak or nonexistent. The growth of managed care and
pharmacy benefits management organizations has intensified price competition
significantly and has magnified the importance of demonstrating not only medical
benefits but also cost advantages as compared with other treatments.

                                      -5-

 
      The Company believes its long-term competitive position depends upon the
success of its research and development endeavors in discovering and developing
innovative products that are clinically- and cost-effective, together with
increased productivity resulting from improved manufacturing methods and
effective sales and marketing efforts. There can be no assurance that the
Company's research and development efforts will result in commercially
successful products or that products manufactured or processes used by the
Company will not become outmoded from time to time as a result of products or
processes developed by its competitors.

                             GOVERNMENTAL REGULATION

      For many years the Company's operations have been regulated extensively by
the federal government, to some extent by state governments, and in varying
degrees by foreign governments. The Federal Food, Drug, and Cosmetic Act, other
federal statutes and regulations, various state statutes and regulations, and
laws and regulations of foreign governments govern to varying degrees the
testing, approval, production, labeling, distribution, post-market surveillance,
advertising, dissemination of information, and promotion of the Company's
products. The lengthy process of laboratory testing, clinical testing, data
analysis and regulatory review necessary for required governmental approvals is
extremely costly and can significantly delay product introductions in a given
market. Promotion, marketing and distribution of pharmaceutical products are
extensively regulated in all major world markets. In addition, the Company's
operations are subject to complex federal, state, local, and foreign
environmental and occupational safety laws and regulations. The Company
anticipates that compliance with regulations affecting the manufacture and sale
of current products and the introduction of new products will continue to
require substantial scientific and technical effort, time, and expense and
significant capital investment.

      In the United States, the Omnibus Budget Reconciliation Act of 1990
requires the Company to provide rebates to state governments on their purchases
of certain Company products under state Medicaid programs. Other cost
containment measures have been adopted or proposed by federal, state, and local
government entities that provide or pay for health care. In most international
markets, the Company operates in an environment of government-mandated cost
containment programs, which may include price controls, discounts and rebates,
restrictions on physician prescription levels, restrictions on reimbursement,
compulsory licenses and generic substitution. The Company expects that
governments inside and outside the United States will continue to propose and/or
adopt a variety of measures to contain health care costs, including
pharmaceutical costs, some of which could adversely affect the Company. As an
example, there are a number of legislative proposals in the United States at
both the state and federal levels intended to provide greater access to drugs
for the elderly that effectively would impose controls on the prices at which
the Company's products are sold for use by the elderly. The Company cannot
predict whether such proposals will be adopted or the extent to which its
business may be affected by these or other potential future legislative or
regulatory developments.

                            RESEARCH AND DEVELOPMENT

      The Company's research and development activities are responsible for the
discovery or development of most of the products the Company offers today. Its
commitment to research and development dates back more than 100 years. The
Company invests heavily in research and development, which management believes
is critical to the Company's long-term competitiveness. The growth in research
and development expenditures and personnel over the past several years

                                      -6-

 
demonstrates both the continued vitality of the Company's commitment and the
increasing costs and complexity of bringing new products to the market. At the
end of 1998, approximately 5,800 people, including a substantial number who are
physicians or scientists holding graduate or postgraduate degrees or highly
skilled technical personnel, were engaged in pharmaceutical and animal health
research and development activities. The Company expended $1.19 billion on these
research and development activities in 1996, $1.37 billion in 1997, and $1.74
billion in 1998.

      The Company's research is concerned primarily with the effects of
synthetic chemicals and natural products on biological systems. The results of
that research are applied to develop products to treat diseases in humans and
animals. The primary effort is devoted to human pharmaceutical products. The
Company concentrates its pharmaceutical research and development efforts in five
therapeutic categories: central nervous system and related diseases; endocrine
diseases, including diabetes and osteoporosis; infectious diseases; cancer; and
cardiovascular diseases. The Company also selectively pursues promising leads in
other therapeutic areas. The Company is actively engaged in biotechnology
research programs involving recombinant DNA, proteins, and genomics (the
development of therapeutics through identification of disease-causing genes and
their cellular function).

      In addition to the research carried on in the Company's own laboratories,
the Company sponsors and underwrites the cost of research and development by
independent organizations, including educational institutions and research-based
pharmaceutical and biotechnology companies, and contracts with others for the
performance of research in their facilities. It utilizes the services of
physicians, hospitals, medical schools, and other research organizations in the
United States and many other countries to establish through clinical evidence
the safety and effectiveness of new products. The Company actively seeks out
opportunities to invest in external research and technologies that hold the
promise to complement and strengthen the Company's own research efforts. These
investments can take many forms, including licensing arrangements,
co-development and co-marketing agreements, joint ventures and outright
acquisitions.

      Extensive work is also conducted in the animal sciences, including animal
nutrition and physiology and veterinary medicine. Certain of the Company's
research and development activities relating to pharmaceutical products may be
applicable to animal health products. An example is the search for agents that
will cure infectious disease.

                                QUALITY ASSURANCE

      The Company's success depends in great measure upon customer confidence in
the quality of the Company's products and in the integrity of the data that
support their safety and effectiveness. The quality of the Company's products
arises from the total commitment to quality in all parts of the Company,
including research and development, purchasing, facilities planning,
manufacturing, and distribution. Quality-assurance procedures have been
developed relating to the quality and integrity of the Company's scientific
information and production processes.

      Control of production processes involves rigid specifications for
ingredients, equipment, facilities, manufacturing methods, packaging materials,
and labeling. Control tests are made at various stages of production processes
and on the final product to assure that the product meets all regulatory
requirements and the Company's standards. These tests may involve chemical and
physical chemical analyses, microbiological testing, testing in animals, or a
combination of these tests. Additional assurance of quality is provided by a
corporate quality-assurance group that

                                      -7-

 
monitors existing pharmaceutical and animal health manufacturing procedures and
systems in the parent company, subsidiaries, and affiliates.

                      EXECUTIVE OFFICERS OF THE REGISTRANT

      The following table sets forth certain information regarding the executive
officers of the Company. All but two of the executive officers have been
employed by the Company in executive or managerial positions during the last
five years. Charles E. Golden joined the Company as Executive Vice President and
Chief Financial Officer and was elected to the Board of Directors in March 1996.
He previously had held a number of executive positions with General Motors
Corporation ("GM") including Vice President of GM and Chairman and Managing
Director of Vauxhall Motors Limited, a GM subsidiary in the United Kingdom, from
1993 to 1996, Vice President and Treasurer from 1992 to 1993, and Treasurer from
1989 to 1992. Thomas Trainer joined the Company in January 1995. Since 1991 he
had served as Vice President and Chief Information Officer of Reebok
International Ltd.

      Except as indicated in the following table, the term of office for each
executive officer expires on the date of the annual meeting of the Board of
Directors, to be held on April 19, 1999, or on the date his or her successor is
chosen and qualified. No director or executive officer of the Company has a
"family relationship" with any other director or executive officer of the
Company, as that term is defined for purposes of this disclosure requirement.
There is no understanding between any executive officer of the Company and any
other person pursuant to which the executive officer was selected.

      NAME                     AGE                      OFFICES
- -------------------------------------------------------------------------------
Randall L. Tobias               57        Former Chairman of the Board (retired
                                          as a director and employee December
                                          31, 1998)

Sidney Taurel                   50        Chairman of the Board (since January
                                          1999), President and Chief Executive
                                          Officer (since June 1998) and a
                                          Director

Charles E. Golden               52        Executive Vice President and Chief
                                          Financial Officer (since March 1996)
                                          and a Director

August M. Watanabe, M.D.        57        Executive Vice President, Science and
                                          Technology (since February 1996) and a
                                          Director

Mitchell E. Daniels, Jr.        49        Senior Vice President, Corporate
                                          Strategy and Policy (since June 1998)

Rebecca O. Goss                 51        Senior Vice President and General
                                          Counsel (since June 1998)

Pedro P. Granadillo             51        Senior Vice President, Human Resources
                                          and Manufacturing (since June 1998)

                                      -8-

 
      NAME                     AGE                      OFFICES
- -------------------------------------------------------------------------------

John C. Lechleiter              45        Senior Vice President, Pharmaceutical
                                          Products (since June 1998)

Bryce D. Carmine                47        President, SERM and Skeletal Products
                                          (since March 1999)*

Alan S. Clark                   64        Former President, U.S. Operations and
                                          Global Marketing (since January 1997)
                                          (retiring April 1999)

Michael L. Eagle                51        Vice President, Manufacturing (since
                                          January 1994)*

Brendan P. Fox, D.V.M.          55        President, Elanco Animal Health (since
                                          January 1991)*

James A. Harper                 51        President, Diabetes and Growth
                                          Disorders Products (since August
                                          1994)*

Gerhard N. Mayr                 52        President, Intercontinental Operations
                                          (since September 1997)*

Richard D. Pilnik               42        Vice President, Global Marketing
                                          (since January 1998)*

Robert N. Postlethwait          50        Former President, Neuroscience
                                          Products (since August 1994) (retiring
                                          May 1999)

William R. Ringo, Jr.           53        President, Internal Medicine Products
                                          (since January 1998)*

Gino Santini                    42        President, U.S. Operations and Global
                                          Marketing (since March 1999)*

Gary Tollefson, M.D., Ph.D.     48        President, Neuroscience Products
                                          (since January 1999)*

Thomas Trainer                  52        Former Vice President, Information
                                          Technology, and Chief Information
                                          Officer (since January 1995) (resigned
                                          March 1999)

Albertus Van den Bergh          45        President, European Operations (since
                                          September 1997)*


                                    EMPLOYEES

      At the end of 1998, the Company had approximately 29,800 employees
(excluding PCS), including approximately 15,400 employees outside the United
States. A substantial number of the Company's employees have long records of
continuous service.

- --------------
* Serves in office until successor is appointed.

                                      -9-

 
       FINANCIAL INFORMATION RELATING TO FOREIGN AND DOMESTIC OPERATIONS

      Financial information relating to foreign and domestic operations, set
forth in the Company's 1998 Annual Report at page 43 under "Segment Information"
(page 6 of Exhibit 13), is incorporated herein by reference.

      Local restrictions on the transfer of funds from branches and subsidiaries
located abroad (including the availability of dollar exchange) have not to date
been a significant deterrent in the Company's overall operations abroad. The
Company cannot predict what effect these restrictions or the other risks
inherent in foreign operations, including possible nationalization, might have
on its future operations or what other restrictions may be imposed in the
future. In addition, changing currency values can either favorably or
unfavorably affect the financial position and results of operations of the
Company. The Company actively manages its foreign exchange risk through various
hedging techniques including the use of foreign currency contracts.


Item 2.  PROPERTIES

      The Company's principal domestic and international executive offices are
located in Indianapolis. At December 31, 1998, the Company owned 14 production
and distribution facilities in the United States and Puerto Rico. Together with
the corporate administrative offices, these facilities contain an aggregate of
approximately 9.5 million square feet of floor area dedicated to production,
distribution and administration. Major production sites include Indianapolis;
Clinton and Lafayette, Indiana; and Carolina and Mayaguez, Puerto Rico. The
Company also leases sales offices in a number of cities located in the United
States and abroad.

      The Company owns production and distribution facilities in 19 countries
outside the United States and Puerto Rico, containing an aggregate of
approximately 4.1 million square feet of floor space. Major production sites
include facilities in the United Kingdom, France, Spain, Ireland, Brazil,
Mexico, and Italy. Leased production and warehouse facilities are utilized in
Puerto Rico and 18 countries outside the United States.

      The Company's research and development facilities in the United States
consist of approximately 3.8 million square feet and are located primarily in
Indianapolis and Greenfield, Indiana. Its major research and development
facilities abroad are located in Belgium, Germany, and the United Kingdom and
contain approximately 387,000 square feet.

      The Company believes that none of its properties is subject to any
encumbrance, easement, or other restriction that would detract materially from
its value or impair its use in the operation of the business of the Company. The
buildings owned by the Company are of varying ages and in good condition.


Item 3.  LEGAL PROCEEDINGS

      Prozac Patent Litigation. In March 1996 the Company was informed by Barr
Laboratories, Inc. ("Barr"), a generic pharmaceutical manufacturer, that it had
submitted an abbreviated new drug application ("ANDA") to the U.S. FDA seeking
to market a generic form of Prozac in the United States several years before the
expiration of the Company's patents. Barr has alleged that

                                      -10-

 
the Company's U.S. patents covering Prozac are invalid and unenforceable. The
compound patent expires in February 2001 and a patent for the process by which
Prozac operates expires in December 2003. These patents are material to the
Company.

      On April 11, 1996, the Company filed suit in the United States District
Court for the Southern District of Indiana seeking a ruling that Barr's
challenge to the Company's patents is without merit. In 1997, the Company was
informed that Geneva Pharmaceuticals, Inc. ("Geneva"), another generic
manufacturer, had submitted a similar ANDA and, like Barr, had asserted that the
Company's U.S. Prozac patents are invalid and unenforceable. On June 23, 1997,
the Company sued Geneva in the same court seeking a similar ruling as in the
Barr suit. The two suits have been consolidated. On January 12, 1999, the trial
court judge for the Southern District of Indiana granted partial summary
judgment in favor of the Company, dismissing the claims of Barr and Geneva based
on the patent doctrines of "best mode" and "double patenting." On January 25,
1999 (the day trial was to have begun), Barr and Geneva agreed to abandon their
remaining two claims (based on the patent doctrines of "anticipation" and
"inequitable conduct") in exchange for a payment of $4 million to be shared
among Barr, Geneva, and a third defendant, Apotex, Inc. Barr and Geneva have
appealed the trial court's January 12, 1999 rulings to the Court of Appeals for
the Federal Circuit.

      In late 1998, three additional generic manufacturers, Zenith Goldline
Pharmaceuticals, Inc., Teva Pharmaceuticals USA, and Cheminor Drugs, Ltd.
together with one of its subsidiaries filed ANDAs for generic forms of Prozac,
asserting that the Company's December 2003 patent is invalid and unenforceable.
Finally, in January 1999, Novex Pharma, a division of Apotex, Inc. filed an ANDA
asserting that both the 2001 and 2003 patents are invalid and unenforceable. The
Company has filed lawsuits in the United States District Court of the Southern
District of Indiana seeking rulings that the four companies' challenges to the
patent(s) are without merit. These suits are in the preliminary stages.

      The Company believes that the claims of the six generic manufacturers are
without merit and that the Company should be successful in this litigation.
However, it is not possible to predict or determine the outcome of this
litigation and accordingly there can be no assurance that the Company will
prevail. An unfavorable outcome could have a material adverse effect on the
Company's consolidated financial position, liquidity, or results of operations.

      Product Liability Litigation. The Company is currently a defendant in a
variety of product liability litigation matters involving primarily
diethylstilbestrol ("DES") and Prozac. In approximately 100 actions, including
several with multiple claimants, plaintiffs seek to recover damages on behalf of
children or grandchildren of women who ingested DES during pregnancy. In another
approximately 10 actions, plaintiffs seek to recover damages as a result of the
ingestion of Prozac.

      Pricing Litigation. The Company has been named, together with numerous
other U.S. prescription pharmaceutical manufacturers and in some cases
wholesalers or distributors, as a defendant in a large number of related actions
brought by retail pharmacies and consumers of prescription pharmaceuticals in
the United States alleging violations of federal or state antitrust laws, or
both, based on the practice of providing discounts or rebates to managed-care
organizations and certain other purchasers. The federal cases have been
consolidated or coordinated in the Northern District of Illinois as In re Brand
Name Prescription Drugs Antitrust Litigation (MDL No. 997).

                                      -11-

 
      The federal suits include a certified class action on behalf of a majority
of retail pharmacies in the United States (the "Federal Class Action"). The
class plaintiffs allege an industrywide agreement in violation of the Sherman
Act to deny favorable pricing on sales of brand-name prescription
pharmaceuticals to certain retail pharmacies in the United States. The other
federal suits (the "Federal Individual Actions"), brought as individual claims
by several thousand pharmacies, allege price discrimination in violation of the
Robinson-Patman Act as well as Sherman Act claims. The suits seek treble damages
and injunctive relief against allegedly discriminatory pricing practices.

      In 1995, the Company and several other manufacturers agreed with the
plaintiffs to settle the Federal Class Action. In addition, in 1997 and again in
1998 the Company reached settlements with two large groups of retail pharmacy
and supermarket chains that were plaintiffs in the Federal Individual Actions.
As a result of the various settlements, the claims of the great majority of the
U.S. retailers are now dismissed. With respect to the remaining Federal
Individual Actions, the District Court has designated certain plaintiffs and
defendants named in the individual suits (not including the Company) to
participate in an initial trial or trials of the claims. No trial dates have
been set. Robinson-Patman claims asserted in the Federal Individual Actions
against nondesignated defendants, including the Company, are stayed.

      In addition, a number of related state court cases were filed. The state
court suits typically seek money damages and injunctive relief against allegedly
discriminatory pricing practices. Cases were brought in Alabama, California,
Minnesota, Mississippi, and Wisconsin by retail pharmacies alleging violations
of various state antitrust and pricing laws, purporting to be class actions on
behalf of all retail pharmacies in those states. Settlements have been approved
in Minnesota and Wisconsin and the cases in those states are now dismissed.
Cases were also brought in state courts in Alabama, Arizona, California,
District of Columbia, Florida, Kansas, Maine, Michigan, Minnesota, New York,
North Carolina, Tennessee, and Wisconsin that purport to be class actions on
behalf of consumers of prescription pharmaceuticals, alleging violations of
state antitrust, pricing or consumer protection laws. In all states except
Alabama and Tennessee, settlements in those cases have been approved and the
cases dismissed.

      Other Matters. In March 1996, the Federal Trade Commission ("FTC")
commenced a non-public investigation focusing on the pricing practices described
under "Pricing Litigation" above. The Company has responded to two subpoenas
from the FTC requesting production of certain documents and other discovery
responses. The Company believes that all of its actions have been lawful and
proper and is cooperating with the investigation.

      The Company is also a defendant in other litigation, including product
liability and patent suits, of a character regarded as normal to its business.

      While it is not possible to predict or determine the outcome of the legal
actions and investigations pending against the Company, the Company believes
that except as noted above, the costs associated with all such matters will not
have a material adverse effect on its consolidated financial position or
liquidity but could possibly be material to the consolidated results of
operations in any one accounting period.


                                      -12-

 
Item 4.  SUBMISSION OF MATTERS TO A VOTE OF SECURITY HOLDERS

      During the fourth quarter of 1998, no matters were submitted to a vote of
security holders.


                                     PART II

Item 5.  MARKET FOR THE COMPANY'S COMMON STOCK AND RELATED STOCKHOLDER MATTERS

      Information relating to the principal market for the Company's common
stock and related stockholder matters, set forth in the Company's 1998 Annual
Report under "Selected Quarterly Data (unaudited)," at page 44 (pages 7-8 of
Exhibit 13), and "Selected Financial Data (unaudited)," at page 45 (page 9 of
Exhibit 13), is incorporated herein by reference.


Item 6.  SELECTED FINANCIAL DATA

      Selected financial data for each of the Company's five most recent fiscal
years, set forth in the Company's 1998 Annual Report under "Selected Financial
Data (unaudited)," at page 45 (page 9 of Exhibit 13), are incorporated herein by
reference.


Item 7.  MANAGEMENT'S DISCUSSION AND ANALYSIS OF RESULTS OF OPERATIONS
         AND FINANCIAL CONDITION

                              REVIEW OF OPERATIONS

Sale of PCS Health-Care-Management Business

      In November 1998, the Company signed a definitive agreement to sell to
Rite Aid Corporation the Company's PCS health-care-management subsidiary for
$1.60 billion in cash. The sale, which was completed in January 1999, will allow
the Company to further focus on pharmaceutical innovation and the realization of
optimal demand for Company products in the marketplace. As a consequence of the
divestiture, the operating results of PCS have been reflected as "discontinued
operations" in the Company's financial statements for all periods and have been
excluded from consolidated sales and expenses reflected therein. The net gain on
disposal will be recognized in the first quarter of 1999. See Note 3 to the
consolidated financial statements for further discussion.

Operating Results From Continuing Operations--1998

      Income from continuing operations (before the 1998 extraordinary charge of
$7.2 million, or $.01 per share) was $2.10 billion, or $1.87 per share, in 1998
and $2.02 billion, or $1.78 per share, in 1997. Comparisons between 1998 and
1997 are made difficult by the impact of several unusual transactions that are
reflected in the Company's operating results for both years. Excluding these
unusual items, which are discussed further below, income from continuing
operations before extraordinary item for 1998 and 1997 would have been $2.17
billion, or $1.94

                                      -13-

 
per share, and $1.83 billion, or $1.62 per share, respectively. This represents
an increase in earnings and earnings per share of 19 percent and 20 percent,
respectively. The 1998 increases are attributed to increased sales, improved
gross margin, reduced interest expense and a lower effective tax rate, partially
offset by increases in operating expenses.

      During 1998, the Company announced a collaboration with ICOS Corporation
to jointly develop and globally commercialize a phosphodiesterase type 5 (PDE5)
inhibitor as an oral therapeutic agent for the treatment of both male and female
sexual dysfunction. The compound is in the development phase (Phase II clinical
trials) and no alternative future uses have been identified. As with many Phase
II compounds, launch of the product, if successful, would not be expected in the
near term. Accordingly, under current accounting rules, the Company's payments
to acquire rights to this compound were required to be charged as a one-time
expense of $127.5 million, which reduced earnings per share by approximately
$.07 net of tax. The Company's reported tax rate was also affected by this item.

      The Company's reported results from continuing operations for 1997 include
the following unusual transactions: a pretax gain of $631.8 million from the
sale of the Company's interest in the DowElanco joint venture, a $97.8 million
noncash charge for an asset impairment as discussed further in the 1997
operating results section, a charge for the settlement of a significant portion
of the Company's remaining retail pharmacy pricing litigation, and a $24.1
million charge for the discontinuance of the research collaboration with
Somatogen, Inc. The Company's reported tax rate for 1997 was also affected by
these transactions.

      The Company's sales for 1998 increased 16 percent, to $9.24 billion. Sales
in the U.S. were $5.84 billion, a 20 percent increase, while sales outside the
U.S. were $3.40 billion, a 9 percent increase. Worldwide sales reflected volume
growth of 15.3 percent and a 2.1 percent increase in selling prices, which were
partially offset by an unfavorable exchange rate impact of 1.8 percent.

      Worldwide pharmaceutical sales increased 17 percent, to $8.62 billion.
Sales growth was led by four of the Company's newer products: Zyprexa, a
treatment for schizophrenia and related psychoses; the cardiovascular agent
ReoPro; the oncolytic product Gemzar; and the osteoporosis prevention agent
Evista, which was launched in the first quarter of 1998; as well as the
antidepressant Prozac. Revenue growth was partially offset by lower sales of
anti-infective products and the antiulcer agent Axid due to continuing generic
competition and other competitive pressures. Total U.S. pharmaceutical sales
increased 20 percent, to $5.55 billion. Growth was driven primarily by increased
volumes. International pharmaceutical sales increased 10 percent, to $3.07
billion. Strong volume growth drove the increase, offset by the effect of
unfavorable exchange rates with selling prices remaining relatively stable. The
adverse exchange rate impact in the Asia-Pacific region did not have a material
impact on worldwide sales in 1998. The Company expects that the deterioration of
the Brazilian economy will have a slight adverse impact on 1999 sales and net
income due to a combination of the negative impact of the changing exchange
rates and weakening local demand.

      Worldwide sales of Prozac in 1998 were $2.81 billion, representing an
increase of 10 percent. Prozac sales in the U.S. increased 13 percent, to $2.27
billion. Sales of Prozac outside the U.S. were substantially the same as 1997.
Continued competitive pressures affected sales globally. In addition, during the
first quarter of 1999 it became apparent that U.S. wholesaler stocking in late
1998 would have a greater negative impact on 1999 sales than had been
anticipated. Based on the 1999 results to date, the Company now anticipates only
slight growth in worldwide Prozac sales in 1999. The actual sales levels will
depend upon the effectiveness of

                                      -14-

 
the Company's marketing efforts in offsetting increased competition, the rate of
growth of the antidepressant market, and U.S. wholesaler stocking patterns.

      Zyprexa posted worldwide sales of $1.44 billion in 1998, representing an
increase of 98 percent. U.S. sales of Zyprexa increased 91 percent, to $1.12
billion. Sales outside the U.S. increased 127 percent, to $317.9 million. Sales
comparisons for Zyprexa benefited to some extent from U.S wholesaler stocking in
the fourth quarter of 1998. The Company expects continued strong sales growth
for Zyprexa in 1999 but at a lower percentage than in 1998.

      Worldwide insulin sales, composed of Humulin, the Company's biosynthetic
human insulin; Humalog, the Company's insulin analog; and the animal-source
insulin Iletin, increased 8 percent, to $1.15 billion, in 1998. Insulin sales in
the U.S. increased 4 percent, to $701.5 million. Insulin sales outside the U.S.
increased 14 percent, to $453.4 million. Worldwide Humulin sales increased 3
percent. U.S. Humulin sales were flat compared with 1997 as they were affected
by both increased sales of Humalog and competition from oral antidiabetic
agents. Humulin sales outside the U.S. increased 8 percent. Worldwide Humalog
sales were $129.6 million, representing an increase of 91 percent, or $61.9
million, over 1997. Iletin sales were essentially flat compared with 1997. The
Company expects moderate growth in worldwide insulin sales in 1999.

      Worldwide sales of anti-infectives decreased 9 percent, to $1.16 billion.
U.S. and international anti-infectives sales declined 20 percent and 4 percent,
respectively. These declines were due, in part, to continued generic competition
in certain markets and the impact of unfavorable exchange rates. Cefaclor,
Lorabid, and Vancocin accounted for the majority of the decline in
anti-infectives sales with declines of 10 percent, 14 percent and 5 percent,
respectively. The Company anticipates that 1999 worldwide sales of
anti-infectives will be below 1998 levels largely due to continued pricing
pressures as a result of generic competition.

      Worldwide Axid sales decreased 20 percent, to $418.0 million, due to
continuing competition from other branded and generic antiulcer agents. The
Company expects a continued decline in Axid sales in 1999.

      As mentioned above, the newer products ReoPro and Gemzar, along with
Evista, which was launched in the first quarter of 1998, contributed
significantly to worldwide sales growth. Worldwide ReoPro sales of $365.4
million reflected an increase of 44 percent. Worldwide Gemzar sales increased 76
percent, to $306.8 million. The Company expects the sales of both ReoPro and
Gemzar to increase in 1999 but at a lower rate than in 1998. Evista had
worldwide sales of $144.1 million and had been introduced in approximately 20
countries by the end of 1998. Sales of Evista benefited somewhat from U.S.
wholesaler stocking in the fourth quarter of 1998. The Company anticipates
strong growth in worldwide Evista sales for 1999.

      Worldwide sales of animal health products increased 4 percent, to $614.4
million. Sales increased 7 percent in the U.S. and 2 percent outside the U.S.
The worldwide sales growth was driven primarily by Micotil, an antibiotic for
bovine respiratory disease; Tylan, an antibiotic for promoting feed efficiency
and growth in swine and cattle; and Surmax, a feed additive performance enhancer
for poultry. Weakness in the general economic condition of the Asia-Pacific
region negatively affected sales of animal health products outside the U.S.
These products have a greater sensitivity to adverse economic conditions in the
Asia-Pacific region than pharmaceutical products.

                                      -15-

 
      The Company's payments under federally mandated Medicaid rebate programs
reduced 1998 sales by approximately $278.6 million compared with approximately
$199.1 million in 1997. The Company anticipates that Medicaid rebates will
increase in 1999 due, in part, to the continuing growth in Zyprexa sales.

      The gross margin improved to 78.2 percent of sales compared with 75.6
percent for 1997. This increase was primarily the result of favorable changes in
product mix and productivity improvements. The Company anticipates that the
gross margin percentage will continue to improve in 1999 due largely to
favorable product mix and the expiration of a royalty obligation on Humulin and
Humalog sales in August 1998.

      Operating expenses (the aggregate of research and development and
marketing and administrative expenses) for 1998, excluding the effect of the
one-time expenses for acquired in-process technology related to the ICOS
collaboration, increased 22 percent. The increase reflects a 27 percent growth
rate in research and development, to $1.74 billion. This growth is the result of
greater investments in both internal research efforts and external research
collaborations. The Company expects research and development expenses in 1999 to
increase at a significantly lower rate but still approximating that of sales
growth. The actual 1999 increase will vary depending upon a number of factors,
particularly the level of research collaboration activity. Marketing and
administrative expenses increased 19 percent, to $2.66 billion. This increase
was driven by increased expenditures to support continued new product launches
around the world, including the U.S. launch of Evista and direct-to-consumer
advertising campaigns in the U.S. In addition to the above, operating expenses
were also affected by investments in the Company's global information technology
capabilities, which include expenditures relating to the Company's Year 2000
computer initiatives and increased compensation accruals due to the Company's
performance-based bonus programs. The Company expects marketing and
administrative expenses to increase at a significantly lower rate in 1999, due
in part to expense-management programs initiated in early 1999.

      Interest expense in 1998 decreased $51.4 million, or 22 percent, due
largely to declines in the Company's borrowings.

      Net other income for 1998 was $149.3 million, a decrease of $12.1 million
from 1997. Net other income in 1998 benefited from gains on the sale of certain
investments and increased interest income. Also, in comparison with 1997, 1998
benefited from the inclusion in the 1997 amount of the charges associated with
the discontinuance of a collaboration with Somatogen, Inc. These increases were
more than offset by the absence of both DowElanco joint venture income and
certain license fee income in 1998.

      The Company's effective tax rate for 1998 was 21.3 percent compared with
30.5 percent for 1997. The Company's 1997 effective tax rate was distorted by
the gain from the sale of DowElanco and the asset impairment charge. The
Company's tax rate for 1997, excluding the impact of these items, was 24.1
percent. Excluding the ICOS transaction discussed previously, the Company's
effective tax rate for 1998 was 22.2 percent. The lower 1998 rate is primarily
the result of changes in the mix of earnings between jurisdictions with lower
tax rates and those with higher rates. The Company expects that a tax rate in
the range of 22 percent to 22.5 percent will be sustainable under present law
for the near term. See Note 11 to the consolidated financial statements for
additional information.

                                      -16-

 
      The Company refinanced an ESOP debenture during 1998. An extraordinary
charge of $7.2 million, net of a $4.8 million income tax benefit, was recorded
as a result of this refinancing.

Operating Results From Continuing Operations--1997

      The Company's operating results from continuing operations for both 1997
and 1996 reflect the impact of several unusual transactions that make
comparisons difficult. As noted above, the Company's reported results from
continuing operations for 1997 include several unusual transactions. As a
consequence of these transactions, 1997 income from continuing operations was
$2.02 billion, or $1.78 per share. This compares with income from continuing
operations in 1996 of $1.63 billion, or $1.45 per share.

      Excluding the unusual items noted previously, income from continuing
operations for 1997 would have been $1.83 billion, or $1.62 per share. After
excluding the income from the sale of the U.S. marketing rights for Ceclor CD
and Keftab to Dura Pharmaceuticals, Inc., from the 1996 amounts, 1997 income and
earnings per share from continuing operations, without the unusual items,
reflect increases from 1996 of 18 and 17 percent, respectively. The 1997
increases are attributed to increased sales, improved gross margin and reduced
interest expense, partially offset by decreased other income.

      The Company's sales for 1997 increased 14 percent, to $7.99 billion. Sales
in the U.S. were $4.88 billion, a 25 percent increase, while sales outside the
U.S. were $3.11 billion, a 1 percent increase. Worldwide sales volume growth of
16 percent and a 2 percent increase in global selling prices were partially
offset by unfavorable exchange rates, which decreased sales by 4 percent.

      Worldwide pharmaceutical sales increased 15 percent, to $7.39 billion. The
sales growth was led by three of the Company's newer products, Zyprexa, ReoPro
and Gemzar, as well as increased sales of Prozac and insulin products. The 1997
growth was achieved despite lower sales of anti-infective products. Total U.S.
pharmaceutical sales increased 25 percent, to $4.61 billion, primarily as a
result of increased volume. International pharmaceutical sales increased 1
percent, to $2.78 billion. Sales volume growth outside the U.S. of 12 percent
was offset largely by unfavorable exchange rates (9 percent) and decreased
selling prices (2 percent).

      Worldwide sales of Prozac in 1997 were $2.56 billion, an increase of 8
percent. Prozac sales in the U.S. increased 17 percent, to $2.02 billion.
International sales of Prozac experienced a decline of 14 percent due largely to
the effects of unfavorable exchange rates, continuing generic competition in
Canada and competitive pressures in France.

      Three of the Company's newer products contributed significantly to the
worldwide sales growth. Specifically, in 1997, Zyprexa, launched in the fourth
quarter of 1996, contributed $729.9 million to worldwide sales and $589.7
million to U.S. sales, which represent increases of $643.0 million and $511.4
million, respectively. ReoPro, launched in 1995, reported worldwide sales of
$254.4 million, reflecting an increase of $105.1 million. Worldwide sales of
Gemzar, launched in the U.S. in May 1996, grew to $174.8 million, representing
an increase over 1996 of $112.9 million.

      Worldwide insulin sales in 1997 increased 9 percent, to $1.07 billion.
Insulin sales in the U.S. increased 6 percent, to $673.8 million, and insulin
sales outside the U.S. increased 14 percent, to $398.2 million. Worldwide sales
of Humulin increased 6 percent, to $934.9 million, for 1997. U.S. Humulin sales
increased 4 percent, to $585.7 million, with growth due to

                                      -17-

 
wholesaler buying patterns being offset partially by the combined effect of
competition from oral antidiabetic agents and increased sales of Humalog.
International Humulin sales increased 9 percent.

      Among other major products, worldwide sales of Axid decreased 1 percent,
to $525.4 million. Axid sales declined 2 percent in the U.S. and increased 3
percent outside the U.S. Worldwide sales of the human growth hormone Humatrope
declined 3 percent.

      Compared with 1996, worldwide anti-infectives sales in 1997 decreased
$193.1 million (13 percent). This decline was due primarily to continued generic
competition in certain markets and the impact of unfavorable exchange rates.
Sales of cefaclor decreased 18 percent, to $442.2 million, accounting for the
majority of this decline. Both U.S. and international anti-infectives sales
reflected declines.

      Worldwide sales of animal health products increased 8 percent over 1996,
driven by volume growth of 10 percent. Sales increased 15 percent in the U.S.
and 2 percent outside the U.S. The worldwide sales increase was primarily due to
increased sales of Micotil and Tylan.

      The Company's payments under federally mandated Medicaid rebate programs
reduced 1997 sales by approximately $199.1 million.

      Gross margin improved to 75.6 percent of sales compared with 73.2 percent
for 1996. This increase was primarily the result of favorable product mix,
production efficiencies and procurement savings.

      Research and development expenses in 1997 increased 15 percent. Expenses
in support of global clinical trials, as well as an increase in external
research collaborations relating to the discovery and development of new
technologies, compounds and delivery systems, drove this increase.

      Marketing and administrative expenses increased 18 percent over 1996.
Overall, the increase was largely due to increased expenditures to support
continued new product launches around the world, including the January 1998
launch of Evista, the Prozac direct-to-consumer advertising campaign,
investments in the Company's global information technology capabilities and
increased compensation accruals due to the Company's performance-based bonus
programs. The charge for the settlement of a significant portion of the
Company's remaining retail pharmacy pricing litigation also contributed to the
1997 increase.

      The asset impairment represents a pretax noncash charge of $97.8 million,
recorded in the second quarter of 1997, primarily to adjust to their fair value
the carrying value of certain long-lived assets of a small portion of the
Company's health-care-management business that was not sold. Fair value was
determined based upon anticipated future cash flows, discounted at a rate
commensurate with the risk involved. This business is now part of a joint
venture, the results of which are immaterial to the consolidated financial
statements.

      On June 30, 1997, The Dow Chemical Company acquired the Company's 40
percent interest in the DowElanco joint venture. The cash purchase price was
$1.2 billion, resulting in an after-tax gain of $303.5 million, or $.27 per
share.

                                      -18-

 
      Interest expense in 1997 decreased $55.3 million (19 percent) due
primarily to a decline in the Company's borrowings.

      Net other income for 1997 amounted to $161.4 million, which was $213.6
million lower than in 1996. The decrease was primarily the result of several
nonrecurring items reflected in the 1996 amount, including the sale of the U.S.
marketing rights for Ceclor CD and Keftab ($91.8 million), income from
codevelopment and comarketing contracts, the sale of marketing rights for ReoPro
in Japan and Tapazole(R) in the U.S., and a higher level of sales of certain
equity securities held by the Company. Net other income for 1997 benefited from
income from outlicensing activity. These increases were partially offset by the
charge for the discontinuance of the collaboration with Somatogen, Inc.

      The Company's reported tax rates for 1997 reflect the effects of the
unusual transactions that occurred during the year. The Company's 1997 tax rate,
excluding the impact of these items, was 24.1 percent compared with the 1996 tax
rate of 23.7 percent.

Discontinued Operations

      Discontinued operations consists of the Company's PCS
health-care-management business. As noted previously, in November 1998, the
Company entered into an agreement to sell PCS for $1.6 billion in cash. The sale
was closed in January 1999 and the resulting net gain on disposal will be
recognized in the first quarter of 1999. See Note 3 to the consolidated
financial statements for further information.

      In the second quarter of 1997, the Company recognized an asset impairment
(a noncash charge) of approximately $2.3 billion to adjust the carrying value of
PCS's long-lived assets, primarily goodwill, to their fair value of
approximately $1.5 billion. The Company determined that PCS's estimated future
undiscounted cash flows were below the carrying value of PCS's long-lived
assets. As a consequence, the carrying value was adjusted to estimated fair
value based on anticipated future cash flows, discounted at a rate commensurate
with the risk involved.

Financial Condition

      As of December 31, 1998, cash, cash equivalents and short-term investments
totaled approximately $1.60 billion compared with $2.02 billion at December 31,
1997. Total debt at December 31, 1998, was $2.37 billion, a decrease of $186.8
million. The decrease in cash was due primarily to stock repurchases and
repayment of debt. The Company has completed its previously announced $2 billion
share repurchase, acquiring approximately 28.3 million shares in 1998. The
Company expects to repurchase shares costing approximately $1 billion in 1999.
The Company believes that cash generated from operations, along with available
cash and cash equivalents, will be sufficient to fund essentially all the
Company's operating needs, including debt service, capital expenditures, share
repurchases and dividends in 1999. The Company anticipates using the proceeds
from the sale of PCS in 1999 for general corporate purposes.

      The Company believes that amounts available through existing commercial
paper programs should be adequate to fund maturities of short-term borrowings.
The outstanding commercial paper is also backed by $2 billion of committed bank
credit facilities.

      In the normal course of business, operations of the Company are exposed to
fluctuations in currency values and interest rates. These fluctuations can vary
the costs of financing, investing

                                      -19-

 
and operating. The Company addresses a portion of these risks through a
controlled program of risk management that includes the use of derivative
financial instruments. The objective of controlling these risks is to limit the
impact on earnings of fluctuations in interest and currency exchange rates. All
derivative activities are for purposes other than trading.

      The Company's primary interest rate risk exposure results from changes in
short-term U.S. dollar interest rates. In an effort to manage interest rate
exposures, the Company strives to achieve an acceptable balance between fixed
and floating rate debt positions and may enter into interest rate swaps to help
maintain that balance. Based on the Company's overall interest rate exposure at
December 31, 1998, including derivatives and other interest rate risk sensitive
instruments, a hypothetical 10 percent change in interest rates applied to the
fair value of the instruments as of December 31, 1998, would have no material
impact on earnings, cash flows or fair values of interest rate risk sensitive
instruments over a one-year period. Similarly, a hypothetical 10 percent change
in interest rates from 1997 applied to the fair value of the instruments as of
December 31, 1997, would have had no material impact on earnings, cash flows or
fair values of interest rate risk sensitive instruments during 1998.

      The Company's foreign currency risk exposure results from fluctuating
currency exchange rates, primarily the strengthening of the U.S. dollar against
the Japanese yen and European currencies. The Company faces transactional
currency exposures that arise when its foreign subsidiaries (or the Company
itself) enter into transactions, generally on an intercompany basis, denominated
in currencies other than their local currency. The Company also faces currency
exposure that arises from translating the results of its global operations to
the U.S. dollar at exchange rates that have fluctuated from the beginning of the
period. The Company uses forward contracts and purchased options to manage its
foreign currency exposures. Company policy outlines the minimum and maximum
hedge coverage of such exposures. Gains and losses on these derivative positions
offset, in part, the impact of currency fluctuations on the existing assets,
liabilities, commitments and anticipated revenues. Considering the Company's
derivative financial instruments outstanding at December 31, 1998, a
hypothetical 10 percent weakening in the exchange rates (primarily against the
U.S. dollar) over a one-year period would decrease earnings by $26.1 million,
while a 10 percent strengthening in the exchange rates would increase earnings
by $45.9 million. Comparatively, considering the Company's derivative financial
instruments outstanding at December 31, 1997, a hypothetical 10 percent
weakening in the exchange rates (primarily against the U.S. dollar) over a
one-year period would have decreased earnings by $51.0 million, while a 10
percent strengthening in the exchange rates would have increased earnings by
$67.8 million. This calculation does not reflect the impact of exchange
gains/losses on the underlying positions that would be offset, in part, by the
results of the derivative instruments.

      In connection with the sale of the Company's PCS subsidiary, PCS
repurchased the Class B stock that had been sold to an institutional investor in
1997. See Note 9 to the consolidated financial statements for additional
information.

      Capital expenditures of $419.9 million during 1998 were $53.6 million more
than in 1997 as the Company continued to invest in research and development
initiatives and related infrastructure. The Company expects near-term capital
expenditures to increase from 1998 levels but to remain well below the
historical peaks of the early 1990s. Sufficient cash flows exist to meet these
near-term requirements.

                                      -20-

 
      Dividends of $.80 per share were paid in 1998, an increase of
approximately 8 percent from the $.74 per share paid in 1997. In the fourth
quarter of 1998, effective for the first quarter dividend in 1999, the quarterly
dividend was increased $.03 per share (15 percent), resulting in an indicated
annual rate for 1999 of $.92 per share. The year 1998 was the 114th consecutive
year in which the Company made dividend payments and the 31st consecutive year
in which dividends have been increased.

Year 2000 Readiness Disclosure

      Many of the Company's global information technology (IT) systems and
non-IT systems, including laboratory and process automation devices, will
require modification or replacement in order to render the systems ready for the
year 2000 (Y2K). In late 1996, the Company initiated a comprehensive program to
reduce the likelihood of a material impact on the business. The numerous
activities that are intended to enable the Company to obtain Y2K readiness
utilize both internal and external resources and are being centrally managed
through a program office. Monthly reports are made to senior management and a
business council comprising various management representatives. In addition,
regular reports are made to the audit committee of the board of directors.

      The Company's inventory of IT systems, including software applications,
has been divided into various categories. Those most critical to the Company's
global operations are generally being assessed and renovated, when necessary,
first. The Company has instituted a process to monitor all critical and
essential replacement and upgrade projects of existing systems to assist in
managing them toward completion in a timely manner. The Company has completed
renovation of approximately 95 percent of its critical applications. The Company
anticipates that substantially all the remaining critical applications will be
completed by March 31, 1999. Of applications deemed essential, the Company
anticipates Y2K readiness of approximately 95 percent by June 30, 1999.

      The most important non-IT systems are various laboratory and process
automation devices. The Company has completed a global assessment of all
devices. Based on this assessment, only a small percentage (10 percent to 13
percent) of all automation devices appear to require upgrade or replacement. The
Company has begun the process of either remediating or replacing these devices
and anticipates that this process will be substantially complete by mid-1999.

      The representatives of the program office have visited numerous global
sites to assess the progress being made toward site readiness. In addition,
several global training programs have occurred to foster the consistent
application of the chosen methodologies.

      The Company has also mailed letters to thousands of vendors, service
providers and customers to determine the extent to which they are prepared for
the Year 2000 issue. These activities are being coordinated through a global
network of regional site and functional coordinators. Many responses have been
received and the Company is identifying the vendors, service providers and
customers that are critical to Lilly through a business impact analysis.
Follow-up interviews are more thoroughly assessing their readiness.

      The Company has begun, but not yet completed, a comprehensive analysis of
the operational problems and costs (including loss of revenues) that would be
reasonably likely to result from the failure by the Company and certain third
parties to complete efforts necessary to achieve Year 2000 compliance on a
timely basis or from abnormal wholesaler or consumer buying patterns in

                                      -21-

 
anticipation of the Year 2000. Contingency plans are beginning to be developed
for the Company and its critical vendors, customers and suppliers to address the
flow of products to the consumer. The contingency planning involves a
multifaceted approach, which may include additional purchases of raw materials,
manufacturing additional finished stock of critical products and/or locating
inventories of products closer to the consumer. Business continuity plans will
be developed to address the Company's approach for dealing with extended
disruptions. In addition, "rapid response" teams will be established to respond
to any issues that occur around the millennium. The Company currently plans to
complete analysis and have contingency plans in place by September 30, 1999.

      The costs of the Company's Year 2000 efforts are based upon management's
best estimates, which are derived using numerous assumptions regarding future
events, including the continued availability of certain resources, third-party
remediation plans and other factors. There can be no assurance that these
estimates will prove to be accurate, and actual results could differ materially
from those currently anticipated. The Company currently estimates it will spend
between $160 and $190 million over the life of the program and that
approximately 55 percent to 60 percent of the anticipated costs were incurred by
the end of 1998. Expenses associated with addressing the Year 2000 issues are
being recognized as incurred.

      The failure to correct a material Year 2000 problem could result in an
interruption in, or a failure of, certain normal business activities or
operations. Such failures could materially and adversely affect the Company's
results of operations. Due to the uncertainty inherent in the Year 2000 problem,
the Company is unable to determine, at this time, whether the consequences of
Year 2000 failures will have a material impact on the Company's results of
operations. The Year 2000 project is expected to significantly reduce the
Company's level of uncertainty about the Year 2000 problem and, in particular,
about the Year 2000 compliance and readiness of its vendors, service suppliers
and customers. The Company believes that, with the completion of the project as
scheduled, the possibility of a material interruption of normal operations
should be reduced.

Euro Conversion

      On January 1, 1999, 11 European nations adopted a common currency, the
euro, and formed the European Economic and Monetary Union (EMU). For a
three-year transition period, both the euro and individual participants'
currencies will remain in circulation. After July 1, 2002, at the latest, the
euro will be the sole legal tender for EMU countries. The adoption of the euro
will affect a multitude of financial systems and business applications as the
commerce of these nations will be transacted in the euro and the existing
national currency.

      The Company is currently addressing euro-related issues and their impact
on information systems, currency exchange rate risk, taxation, contracts,
competition and pricing. Action plans currently being implemented are expected
to result in compliance with all laws and regulations; however, there can be no
certainty that such plans will be successfully implemented or that external
factors will not have an adverse effect on the Company's operations. Any costs
of compliance associated with the adoption of the euro will be expensed as
incurred and the Company does not expect these costs to be material to its
results of operations, financial condition or liquidity.


                                      -22-

 
Legal And Environmental Matters

      Barr Laboratories, Inc. (Barr), and Geneva Pharmaceuticals, Inc. (Geneva),
have each submitted an Abbreviated New Drug Application (ANDA) seeking FDA
approval to market generic forms of Prozac before the expiration of the
Company's patents. The ANDAs assert that two U.S. patents held by Lilly covering
Prozac are invalid and unenforceable. The Company filed suit against Barr and
Geneva in federal court in Indianapolis seeking a ruling that Barr's challenge
to Lilly's patents is without merit. On January 12, 1999, the trial court
granted summary judgment in favor of Lilly on two of the four claims raised by
Barr and Geneva against Lilly's patents. Barr and Geneva have appealed that
decision. On January 25, 1999, Barr and Geneva dismissed their other two claims
in exchange for a $4 million payment, which Barr and Geneva will share with a
third defendant. In late 1998, three other generic pharmaceutical companies,
Zenith Goldline Pharmaceuticals, Inc., Teva Pharmaceuticals USA, and Cheminor
Drugs, Ltd. together with one of its subsidiaries each filed ANDAs for generic
forms of Prozac, asserting that the later of the two patents (expiring in
December 2003) is invalid and unenforceable. Finally, in January 1999, Novex
Pharma, a division of Apotex, Inc., filed an ANDA challenging both patents.
Lilly has filed suits against the four companies in federal court in
Indianapolis. The suits are in a very early stage. While the Company believes
that the claims of the six generic companies are without merit, there can be no
assurance that the Company will prevail. An unfavorable outcome of this
litigation could have a material adverse effect on the Company's consolidated
financial position, liquidity or results of operations.

      As with other industrial enterprises, the Company's operations are subject
to complex and changing federal, state and local environmental laws and
regulations, which will continue to require capital investment and operational
expenses. The Company also has been designated a potentially responsible party
under the Comprehensive Environmental Response, Compensation and Liability Act,
commonly known as Superfund, with respect to fewer than 10 sites with which the
Company had varying degrees of involvement. Further, the Company continues
remediation of certain of its own properties consistent with current
environmental practices. The Company has accrued for estimated Superfund costs
and remediation of its own properties, taking into account, as applicable,
available information regarding site conditions, potential cleanup methods,
estimated costs and the extent to which other parties can be expected to
contribute to those costs. The Company reached a settlement with its primary
liability insurance carrier providing for coverage for certain environmental
liabilities and has instituted litigation seeking coverage from certain excess
carriers. In addition, the Company has accrued for certain other environmental
matters.

      During 1998, the Company continued to be named as a defendant in a small
number of product liability lawsuits involving Prozac. However, continuing a
trend seen in recent years, the number of pending cases declined from levels of
the previous year.

      The Company continues to be a defendant, together with numerous other U.S.
prescription drug manufacturers, in related suits brought under federal and
state antitrust laws by many retail pharmacies and, in some cases, consumers.
The Company has now resolved the great majority of the retailer claims and,
subject in certain cases to court approval, has also settled the great majority
of the consumer claims.

      While it is not possible to predict or determine the outcome of the
patent, product liability, antitrust or other legal actions brought against the
Company or the ultimate cost of environmental matters, the Company believes
that, except as noted above, the costs associated with all such

                                      -23-

 
matters will not have a material adverse effect on its consolidated financial
position or liquidity but could possibly be material to the consolidated results
of operations in any one accounting period. For additional information on
litigation and environmental matters, see Item 3 above and Note 13 to the
consolidated financial statements.

Private Securities Litigation Reform Act Of 1995 --
A Caution Concerning Forward-Looking Statements

      Under the safe harbor provisions of the Private Securities Litigation
Reform Act of 1995, the Company cautions investors that any forward-looking
statements or projections made by the Company, including those made in this
document, are based on management's expectations at the time they are made, but
they are subject to risks and uncertainties that may cause actual results to
differ materially from those projected. Economic, competitive, governmental,
technological and other factors that may affect the Company's operations and
prospects are discussed in Exhibit 99 to the Company's most recent report on
Forms 10-Q and 10-K filed with the Securities and Exchange Commission.

Additional Information

      Additional financial information, presented as graphs in the Company's
1998 Annual Report to Shareholders, is found at pages 29-32 of Exhibit 13 and is
incorporated herein by reference.


Item 7A. QUANTITATIVE AND QUALITATIVE DISCLOSURES ABOUT MARKET RISK

      Quantitative and qualitative disclosures about market risk (e.g., interest
rate risk and foreign currency exchange risk) are set forth under Item 7 above
at "Review of Operations -- Financial Condition" and are incorporated by
reference herein.


Item 8.  FINANCIAL STATEMENTS AND SUPPLEMENTARY DATA

      The consolidated financial statements of the Company and its subsidiaries,
listed in Item 14(a)1 and included in the Company's 1998 Annual Report at pages
32, 36-37, 41 and 42 (Consolidated Statements of Income, Consolidated Balance
Sheets, Consolidated Statements of Cash Flows, and Consolidated Statements of
Comprehensive Income), page 43 (Segment Information), and pages 46-59 (Notes to
Consolidated Financial Statements) (together, pages 1-6 and 10-26 of Exhibit
13), and the Report of Independent Auditors set forth in the Company's 1998
Annual Report at page 61 (page 28 of Exhibit 13), are incorporated herein by
reference.

      Information on quarterly results of operations, set forth in the Company's
1998 Annual Report under "Selected Quarterly Data (unaudited)," at page 44
(pages 7-8 of Exhibit 13), is incorporated herein by reference.

                                      -24-

 
Item 9.  DISAGREEMENTS ON ACCOUNTING AND FINANCIAL DISCLOSURE

      None.


                                    PART III

Item 10. DIRECTORS AND EXECUTIVE OFFICERS OF THE REGISTRANT

      Information relating to the Company's directors, set forth in the
Company's Proxy Statement dated March 4, 1999 (the "Proxy Statement"), under
"Item 1. Election of Directors" at pages 3-6, is incorporated herein by
reference. Information relating to the Company's executive officers is set forth
at pages 8-9 of this Form 10-K under "Executive Officers of the Registrant."
Information relating to certain filing obligations of directors and executive
officers under the federal securities laws, set forth in the Proxy Statement
under "Other Matters -- Section 16(a) Beneficial Ownership Reporting Compliance"
at page 23, is also incorporated herein by reference.


Item 11. EXECUTIVE COMPENSATION

      Information relating to executive compensation, set forth in the Proxy
Statement under "Directors' Compensation", "Executive Compensation",
"Compensation Committee Interlocks", "Retirement Plan", and "Change-in-Control
Severance Pay Arrangements" at pages 9-18, is incorporated herein by reference,
except that the Compensation Committee Report and Performance Graph are not so
incorporated.


Item 12. SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT

      Information relating to ownership of the Company's common stock by persons
known by the Company to be the beneficial owners of more than 5 percent of the
outstanding shares of common stock and by management, set forth in the Proxy
Statement under "Common Stock Ownership by Directors and Executive Officers," at
page 8, and "Principal Holders of Common Stock," at page 9, is incorporated
herein by reference.


Item 13. CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS

      None.


                                      -25-

 
                                     PART IV

Item 14. EXHIBITS, FINANCIAL STATEMENT SCHEDULES, AND REPORTS ON FORM 8-K

(a)1.    Financial Statements

      The following consolidated financial statements of the Company and its
subsidiaries, included in the Company's 1998 Annual Report at the pages
indicated in parentheses, are incorporated by reference in Item 8:

         Consolidated Statements of Income--Years Ended December 31, 1998, 1997,
         and 1996 (page 32) (page 1 of Exhibit 13)

         Consolidated Balance Sheets--December 31, 1998 and 1997 (pages 36-37)
         (pages 2-3 of Exhibit 13)

         Consolidated Statements of Cash Flows--Years Ended December 31, 1998,
         1997, and 1996 (page 41) (page 4 of Exhibit 13)

         Consolidated Statements of Comprehensive Income--Years Ended December
         31, 1998, 1997, and 1996 (page 42) (page 5 of Exhibit 13)

         Segment Information (page 43) (page 6 of Exhibit 13)

         Notes to Consolidated Financial Statements (pages 46-59) (pages 10-26
         of Exhibit 13)

(a)2.    Financial Statement Schedules

      The consolidated financial statement schedules of the Company and its
subsidiaries have been omitted because they are not required, are inapplicable,
or are adequately explained in the financial statements.

      Financial statements of interests of 50 percent or less, which are
accounted for by the equity method, have been omitted because they do not,
considered in the aggregate as a single subsidiary, constitute a significant
subsidiary.

(a)3.    Exhibits

         3.1      Amended Articles of Incorporation

         3.2      By-laws

         4.1      Rights Agreement dated as of July 20, 1998, between Eli Lilly
                  and Company and First Chicago Trust Company of New York, as
                  Rights Agent

         4.2      Form of Indenture with respect to Debt Securities dated as of
                  February 1, 1991, between Eli Lilly and Company and Citibank,
                  N.A., as Trustee

                                      -26-

 
         4.3      Form of Standard Multiple-Series Indenture Provisions dated,
                  and filed with the Securities and Exchange Commission on,
                  February 1, 1991

         4.4      Form of Fiscal and Paying Agency Agreement dated February 7,
                  1995, between Eli Lilly and Company and Citibank, N.A., Fiscal
                  and Paying Agent, including forms of Notes, relating to 8-1/8%
                  Notes Due February 7, 2000(1)

         4.8      Form of Fiscal and Paying Agency Agreement dated February 7,
                  1995, between Eli Lilly and Company and Citibank, N.A., Fiscal
                  and Paying Agent, including forms of Notes, relating to 8-3/8%
                  Notes Due February 7, 2005(1)

         10.1     1989 Lilly Stock Plan, as amended(2)

         10.2     1994 Lilly Stock Plan, as amended(2)

         10.3     1998 Lilly Stock Plan(2)

         10.4     The Lilly Deferred Compensation Plan, as amended(2)

         10.5     The Lilly Directors' Deferral Plan, as amended(2)

         10.6     The Eli Lilly and Company EVA(R)Bonus Plan, as amended(2),(3)

         10.7     Eli Lilly and Company Change in Control Severance Pay Plan for
                  Select Employees(2)

         12.      Computation of Ratio of Earnings to Fixed Charges

         13.      Annual Report to Shareholders for the Year Ended December 31,
                  1998 (portions incorporated by reference into this Form 10-K)

         21.      List of Subsidiaries

         23.      Consent of Independent Auditors

         27.      Financial Data Schedules for the periods indicated:

                  27.1     Year ended December 31, 1998

                  27.2     Restated for year ended December 31, 1996

                  27.3     Restated for quarter ended March 31, 1997

                  27.4     Restated for six months ended June 30, 1997

- ---------
(1) This exhibit is not filed with this Report. Copies will be furnished to the
    Securities and Exchange Commission upon request.

(2) Indicates management contract or compensatory plan.

(3) EVA(R) is a registered trademark of Stern Stewart & Co.

                                      -27-

 
                  27.5     Restated for nine months ended September 30, 1997

                  27.6     Restated for year ended December 31, 1997

                  27.7     Restated for quarter ended March 31, 1998

                  27.8     Restated for six months ended June 30, 1998

                  27.9     Restated for nine months ended September 30, 1998

         99.      Cautionary Statement under Private Securities Litigation
                  Reform Act of 1995 -- "Safe Harbor" for Forward-Looking
                  Disclosures



(b)  Reports on Form 8-K

      The Company filed no reports on Form 8-K during the fourth quarter of
1998. During the third quarter, the Company filed a report on Form 8-K on July
23, 1998, in connection with the adoption of a new Shareholder Rights Plan to
replace the Plan that expired on July 28, 1998.



                                      -28-

 
                                   SIGNATURES

         Pursuant to the requirements of Section 13 or 15(d) of the Securities
Exchange Act of 1934, the Registrant has duly caused this report to be signed on
its behalf by the undersigned thereunto duly authorized.


                                       ELI LILLY AND COMPANY


                                       By /s/Sidney Taurel
                                         ---------------------
                                         Sidney Taurel, Chairman of the Board,
                                         President and  Chief Executive Officer

                                                              March 25, 1999


         Pursuant to the requirements of the Securities Exchange Act of 1934,
this report has been signed below on March 25, 1999 by the following persons on
behalf of the Registrant and in the capacities indicated.


    SIGNATURE                                   TITLE
- ------------------------------------------------------------------------------

/s/ Sidney Taurel                    Chairman of the Board, President, Chief
- -----------------------------        Executive Officer, and a Director
(SIDNEY TAUREL)                      (principal executive officer)


/s/ Charles E. Golden                Executive Vice President, Chief Financial
- -----------------------------        Officer, and a Director (principal
(CHARLES E. GOLDEN)                  financial officer)


/s/ Arnold C. Hanish                 Chief Accounting Officer
- -----------------------------        (principal accounting officer)
(ARNOLD C. HANISH)


/s/ Steven C. Beering, M.D.          Director
- -----------------------------
(STEVEN C. BEERING, M.D.)


/s/ Karen N. Horn                    Director
- -----------------------------
(KAREN N. HORN, Ph.D.)


                                      -29-

 
    SIGNATURE                                   TITLE
- ------------------------------------------------------------------------------

/s/ Alfred G. Gilman, M.D., Ph.D.    Director
- -----------------------------
(ALFRED G. GILMAN, M.D., Ph.D.)


/s/ Kenneth L. Lay, Ph.D.            Director
- -----------------------------
(KENNETH L. LAY, Ph.D.)


/s/ Franklyn G. Prendergast,
M.D., Ph.D.                          Director
- -----------------------------
(FRANKLYN G. PRENDERGAST,
M.D., Ph.D.)


/s/ Kathi P. Seifert                 Director
- -----------------------------
(KATHI P. SEIFERT)


/s/ August M. Watanabe, M.D.         Director
- -----------------------------
(AUGUST M. WATANABE, M.D.)


/s/ Alva O. Way                      Director
- -----------------------------
(ALVA O. WAY)




                                      -30-

 
TRADEMARKS USED IN THIS REPORT



      Trademarks or service marks owned by Eli Lilly and Company or its
subsidiaries or affiliates, when first used in this Report, appear with an
initial capital and are followed by the symbol (R) or (TM), as applicable. In
subsequent uses of the marks in the Report, the symbols are omitted.

 
INDEX TO EXHIBITS



      The following documents are filed as part of this report:
Exhibit Location - -------- -------- 3.1 Amended Articles of Incorporation Incorporated by reference from Exhibit 3 to the Company's Report on Form 10-Q for the quarter ended September 30, 1998 3.2 By-laws Incorporated by reference from Exhibit 3 to the Company's Report on Form 10-Q for the quarter ended June 30, 1998 4.1 Rights Agreement dated as of July 20, 1998, Incorporated by reference from between Eli Lilly and Company and First Chicago Exhibit 1 to the Company's Report on Trust Company of New York, as Rights Agent Form 8-K filed July 23, 1998 4.2 Form of Indenture with respect to Debt Securities Incorporated by reference from dated as of February 1, 1991, between Eli Lilly Exhibit 4.1 to the Company's Registration and Company and Citibank, N.A., as Trustee Statement on Form S-3, Registration No. 33-38347 4.3 Form of Standard Multiple-Series Indenture Incorporated by reference from Provisions dated, and filed with the Securities Exhibit 4.2 to the Company's Registration and Exchange Commission on February 1, 1991 Statement on Form S-3, Registration No. 33-38347
Exhibit Location - -------- -------- 4.6 Form of Fiscal and Paying Agency Agreement dated * July 8, 1993, between Eli Lilly and Company and Citibank, N.A., Fiscal and Paying Agent, including forms of Notes, relating to 5-1/2% Notes Due 1998 4.7 Form of Fiscal and Paying Agency Agreement dated * February 7, 1995, between Eli Lilly and Company and Citibank, N.A., Fiscal and Paying Agent, including forms of Notes, relating to 8-1/8% Notes Due February 7, 2000 4.8 Form of Fiscal and Paying Agency Agreement dated * February 7, 1995, between Eli Lilly and Company and Citibank, N.A., Fiscal and Paying Agent, including forms of Notes, relating to 8-3/8% Notes Due February 7, 2005 10.1 1989 Lilly Stock Plan, as amended Incorporated by reference from Exhibit 10.2 to the Company's Report on Form 10-K for the fiscal year ended December 31, 1993 10.2 1994 Lilly Stock Plan, as amended Incorporated by reference from Exhibit 10 to the Company's Report on Form 10-Q for the quarter ended September 30, 1996 10.3 1998 Lilly Stock Plan Incorporated by reference from Exhibit A to the Company's proxy statement dated March 4, 1998 10.4 The Lilly Deferred Compensation Plan, as amended Incorporated by reference from Exhibit 10.4 to the Company's Report on Form 10-K for the fiscal year ended December 31, 1994
-2-
Exhibit Location - -------- -------- 10.5 The Lilly Directors' Deferral Plan, as amended Attached 10.6 The Eli Lilly and Company EVA(R)Bonus Plan, as Attached amended 10.7 Eli Lilly and Company Change in Control Severance Attached Pay Plan for Select Employees 12. Computation of Ratio of Earnings to Fixed Charges Attached 13. Annual Report to Shareholders for the Year Ended Attached December 31, 1998 (portions incorporated by reference in this Form 10-K) 21. List of Subsidiaries Attached 23. Consent of Independent Auditors Attached 27. Financial Data Schedules for the periods indicated: 27.1 Year ended December 31, 1998 27.2 Restated for year ended December 31, 1996 27.3 Restated for quarter ended March 31, 1997 27.4 Restated for six months ended June 30, 1997 27.5 Restated for nine months ended September 30, 1997 27.6 Restated for year ended December 31, 1997
-3-
27.7 Restated for quarter ended March 31, 1998 27.8 Restated for six months ended June 30, 1998 27.9 Restated for nine months ended September 30, 1998 99. Cautionary Statement Under Private Securities Attached Litigation Reform Act of 1995 -- "Safe Harbor" for Forward-Looking Disclosures

 
                                                                  Exhibit 10.5

                       THE LILLY DIRECTORS' DEFERRAL PLAN
              (As amended and restated through December 21, 1998)


Section 1. Establishment of the Plan.

Effective January 1, 1996, there is hereby established a plan whereby certain
Directors of the Company who are not current salaried employees of the Company
may voluntarily defer compensation (the "Deferred Compensation" portion of the
Plan), and certain Directors of the Company who are not current or former
full-time salaried employees of the Company can share in the long-term growth of
the Company by acquiring an ownership interest in the Company (the "Deferred
Stock" portion of the Plan). Prior to January 1, 1996, the Company maintained
the Deferred Compensation portion of the Plan and the Deferred Stock portion of
the Plan as two separate plans, The Lilly Directors' Deferred Compensation Plan
and The Lilly Non-Employee Directors' Deferred Stock Plan, respectively (the
"Prior Plans"). The Plan is deemed to consist of the amounts held under the
Prior Plans, and any election made by a Director under the Prior Plans, unless
and until amended by the Director in accordance with this Plan, shall remain in
effect under this Plan.

Section 2. Definitions.

When used in the Plan, the following terms shall have the definitions set forth
in this Section 2:

         2.1. Accrual Date. The term "Accrual Date" means the first day in
December of each calendar year on which the common stock of the Company is
traded, or such other annual date, not earlier than the third Monday in
February, established by the Committee as the date as of which Shares are
allocated to each Share Account.

         2.2. Beneficiary. The term "Beneficiary" means the beneficiary or
beneficiaries (including any contingent beneficiary or beneficiaries) designated
pursuant to subsection 8.3 hereof.

         2.3.  Board of Directors.  The term "Board of Directors" means the
Board of Directors of the Company.

         2.4.  Committee.  The term "Committee" refers to the Directors and
Corporate Governance Committee of the Board of Directors.

         2.5.  Company.  The term "Company" means Eli Lilly and Company.

 
         2.6. Company Credit. The term "Company Credit" means an amount
computed, and credited annually to a Participant's Deferred Compensation Account
at a rate that is two percent (2%) above the rate that the Treasurer of the
Company determines was the prime rate of interest charged by Chemical Bank, New
York, New York or its successor bank (the "Bank"), on loans made on the
immediately preceding December 15 or, if the Bank was closed on December 15, the
last day preceding December 15 on which the Bank was open for business.

         2.7. Compensation. The term "Compensation" means the retainer and the
aggregate of all meeting fees to which a Director is entitled for services
rendered to the Company as a Director.

         2.8. Deferral Allocation Date. The term "Deferral Allocation Date"
means the third Monday of any month, or if Shares are not traded on The New York
Stock Exchange on such third Monday of the month, the last day before the third
Monday of the month on which Shares are traded on The New York Stock Exchange,
that follows the earlier of (a) the date on which an amount deferred under the
Plan would have been paid in cash if a deferral election had not been made
hereunder, or (b) in the case of an award of compensation which by its terms is
subject to a deferred payment date, the date of award.

         2.9. Deferred Amount. The term "Deferred Amount" means the amount of a
Deferred Compensation Participant's Compensation that the Participant elects to
defer in accordance with Section 4 hereof.

         2.10. Deferred Compensation Participant. The term "Deferred
Compensation Participant" means a Director who is not a salaried employee of the
Company and who has elected to defer all or part of his Compensation pursuant to
the Plan in accordance with Section 4 hereof.

         2.11. Deferred Stock Participant. The term "Deferred Stock Participant"
means a Director who is not a current or former full-time salaried employee of
the Company and who becomes a Participant in the Plan in accordance with Section
3 hereof.

         2.12.  Director.  The term "Director" means each member of the Board of
Directors.

         2.13. Dividend Allocation Date. The term "Dividend Allocation Date"
means the first Monday that (a) follows a Dividend Payment Date and (b) is the
third Monday of a Month.

                                      -2-

 
         2.14. Dividend Payment Date. The term "Dividend Payment Date" means the
date as of which the Company pays a cash dividend on Shares.

         2.15. Dividend Record Date. The term "Dividend Record Date" means, with
respect to any Dividend Payment Date, the date established by the Board of
Directors as the record date for determining shareholders entitled to receive
payment of the dividend.

         2.16. Individual Accounts. The term "Individual Accounts" or "Accounts"
means the separate accounts (the Deferred Compensation Account and the Share
Account), described in Section 7 hereof, one or both of which is established
under the Plan for each Participant. When used in the singular, the term shall
refer to one of these two accounts, as the context requires.

         2.17.  Participant.  The term "Participant" means a Director who is a
Deferred Stock Participant, a Deferred Compensation Participant, or both, as the
case may be.

         2.18. Plan. The term "Plan" means The Lilly Directors' Deferral Plan,
as set forth herein and as it may be amended from time to time.

         2.19.  Share.  The term "Share" means a share of common stock of the
Company.

Section 3. Deferred Stock Participants.

Each Director who participated in The Lilly Non-Employee Directors' Deferred
Stock Plan immediately before the effective date of this Plan shall continue as
a Deferred Stock Participant on such effective date, and all elections in effect
under The Lilly Non-Employee Directors' Deferred Stock Plan shall remain in
effect under this Plan, unless and until amended in accordance with this Plan.
Each person who is thereafter elected or appointed as a Director, and who is not
and has never been a full-time salaried employee of the Company, shall become a
Deferred Stock Participant beginning with the month in which such Director takes
office. A Deferred Stock Participant shall cease to participate in the Plan when
the Participant ceases to be a Director. For purposes of the Plan, a Deferred
Stock Participant shall be deemed to cease to be a Director on the first day of
the month next following the month in which he or she last serves as a Director.

Section 4.  Deferred Compensation Participants.

Each Director who participated in The Lilly Directors' Deferred Compensation
Plan immediately before the effective date of the Plan shall continue as a
Deferred Compensation Participant on such effective date, and

                                      -3-

 
all elections in effect under The Lilly Directors' Deferred Compensation Plan
shall remain in effect under this Plan, unless and until amended in accordance
with this Plan. Prior to the beginning of each calendar year, any Director who
is not a salaried employee of the Company may defer the receipt of Compensation
to be earned by the Director during such year by filing with the Company a
written election that:

                  (i) defers payment of a designated amount (of one Thousand
Dollars ($1,000) or more) or percentage of his Compensation for services
attributable to the following calendar year or portion thereof (the "Deferred
Amount");

                  (ii) specifies the payment option selected by the Participant
pursuant to subsection 8.2 hereof for such Deferred Amount; and

                  (iii) specifies the option selected by the Participant
pursuant to Section 5 hereof for such Deferred Amount.

The amount deferred may not exceed the Director's Compensation for the calendar
year. Notwithstanding the foregoing, any individual who is newly elected or
appointed to serve as a Director may, not later than thirty (30) days after his
election or appointment becomes effective, elect in accordance with the
preceding provisions of this Section 4, to defer the receipt of Compensation
earned during the portion of the current calendar year that follows the filing
of the election with the Company. Except as provided in subsections 8.2 and 8.4
hereof, any elections made pursuant to this Section 4 with respect to a calendar
year shall be irrevocable when made. If a Participant fails to make an election
under section 5 with respect to his or her Deferred Amount for a future calendar
year, the Participant's previous election shall remain in effect, provided that
the Participant may amend his or her election with regard to a future calendar
year at any time.

Section 5.  Form of Deferred Compensation Credits.

         5.1. Deferred Compensation Account. Except with respect to the deferral
of Compensation for a calendar year in which a Deferred Compensation Participant
elects to have all or a percentage of the Deferred Amount credited in Shares in
accordance with subsection 5.2 hereof, the Deferred Amount shall be denominated
in U.S. dollars and credited to the Participant's Deferred Compensation Account
pursuant to subsection 7.1 hereof.

                                      -4-

 
         5.2. Shares. Prior to the beginning of each calendar year, a Deferred
Compensation Participant may elect to have all or a percentage of the Deferred
Amount for the following calendar year credited in Shares and allocated to the
Participant's Share Account pursuant to subsection 7.2 hereof.

         5.3. Transfer of Deferred Compensation Account Balance to Share
Account. Prior to the effective date of the Plan, a Deferred Compensation
Participant may elect to have all or a portion of his or her final credited
account balance in The Lilly Directors' Deferred Compensation Plan converted to
Shares and credited to the Participant's Share Account. Such conversion shall
take place as of January 1, 1996 based upon the combined average of the high and
low prices of Shares on The New York Stock Exchange on each of the last five (5)
days of 1995 on which Shares are traded on The New York Stock Exchange. Such
conversion shall, however, be contingent upon receipt by the Company of (a) a
no-action letter from the Securities and Exchange Commission ("SEC"), or (b) an
opinion of counsel satisfactory to the Company, to the effect that such
conversion shall not disqualify the Participant from being a "is interested
person" within the meaning of prior SEC Rule 16b-3(d)(3) and new SEC Rule
16b-3(c)(2)(i) for purposes of administering the Company's employee stock
incentive plans.

Section 6.  Allocations to Share Accounts.

         6.1. Allocation of Shares. As of the Accrual Date of each calendar
year, there shall be allocated to the Share Account of each Deferred Stock
Participant, as part of the compensation to such Deferred Stock Participant for
service on the Board of Directors, seven hundred (700) Shares (or such other
number of Shares as may be specified from time to time by resolution of the
Board of Directors), at the average of the high and low prices of Shares on The
New York Stock Exchange on the Accrual Date. Shares allocated to each Deferred
Stock Participant's Share Account shall be hypothetical and not issued or
transferred by the Company until payment is made pursuant to Section 8 hereof.

         6.2. Special Allocation. As of February 1, 1996, there shall be
allocated to the Share Account of each Deferred Stock Participant the number of
Shares having a market value (calculated as set forth below) equal to the
present value as of December 31, 1995 of the accrued benefit of the Participant
in The Lilly Non-Employee Directors' Retirement Plan, whether or not such
Participant was vested in such benefit on that date. Such present value
calculation shall be performed by the Company in its discretion and shall be
converted to Shares based upon the combined average of the high and low prices
of Shares on The New York Stock Exchange on each of the last five (5) days
preceding February 1, 1996 on which Shares are traded on The

                                      -5-

 
New York Stock Exchange. Such conversion shall, however, be contingent upon
receipt by the Company of (a) a no-action letter from the Securities and
Exchange Commission ("SEC"), or (b) an opinion of counsel satisfactory to the
Company, to the effect that such conversion shall not disqualify the participant
from being a "disinterested person" within the meaning of prior SEC Rule
16b-3(d)(3) and new SEC Rule 16b-3(c)(2)(i) for purposes of administering the
Company's employee stock incentive plans.

Section 7.  Individual Accounts.

The Company shall maintain Individual Accounts for Participants, as follows:

         7.1. Deferred Compensation Account. The Company shall maintain a
Deferred Compensation Account in the name of each Deferred Compensation
Participant in respect of each calendar year the Deferred Compensation
Participant elects to defer the receipt of Compensation pursuant to Section 4
hereof and does not elect to have the Deferred Amount for such calendar year
credited in Shares pursuant to subsection 5.2 hereof. The opening balance of
each Deferred Compensation Account on January 1, 1996 shall be equal to the
closing balance on December 31, 1995 of the corresponding account maintained
under The Lilly Directors' Deferred Compensation Plan, less any portion of such
account converted to Shares and allocated to the Participant's Share Account
pursuant to subsection 5.3 hereof. The Deferred Compensation Account shall be
denominated in U.S. dollars, rounded to the nearest whole cent. A Deferred
Amount allocated to a Deferred Compensation Account pursuant to subsection 5.1
hereof shall be credited to the Deferred Compensation Account as of the Deferral
Allocation Date.

         7.2. Share Account. The Company shall maintain a Share Account for each
Deferred Stock Participant and for each Deferred Compensation Participant who
elects to have a Deferred Amount credited in Shares pursuant to subsection 5.2
hereof, or who elects to convert all or a portion of his or her final account
balance under The Lilly Directors' Deferred Compensation Plan to Shares pursuant
to subsection 5.3 hereof. The opening balance of each Share Account on January
1, 1996, shall be equal to the closing balance on December 31, 1995, of the
corresponding Share Account maintained under The Lilly Non-Employee Directors'
Deferred Stock Plan. The Share Account shall be denominated in Shares, and shall
be maintained in fractions rounded to three (3) decimal places.

         Shares allocated to a Deferred Compensation Participant's Share Account
in accordance with the Participant's election under subsection 5.2 hereof shall
be credited to the Participant's Share Account as of the Deferral Allocation
Date. Shares and, if necessary, fractional Shares, shall be

                                      -6-

 
credited to a Participant's Share Account based upon the average of the high and
low price of Shares on The New York Stock Exchange on the Deferral Allocation
Date.

         7.3. Former Interest Account. All balances in the Account known
previously as the "Interest Account" under The Lilly Non-Employee Directors'
Deferred Stock Plan shall be transferred to the Share Account effective on
January 1, 1996, utilizing the same price of Shares set forth in subsection 5.3
hereof for purposes of the calculation.

         7.4. Accrual of Company Credit. The Treasurer of the Company shall
determine the annual rate of Company Credit on or before December 31 of each
calendar year. This rate shall be effective for the following calendar year. The
Company Credit shall accrue monthly, at one-twelfth of the applicable annual
rate, on all amounts credited to a Participant's Deferred Compensation Account,
including the Company Credits for prior years. The Company Credit shall not
accrue on any amount distributed to a Participant (or to the Participant's
Beneficiary) during the month for which the accrual is determined, except where
an amount is distributed to a Beneficiary in the month of the Participant's
death. The Company Credit for each year shall be credited to each Deferred
Compensation Account as of December 31 of that year and shall be compounded
monthly.

         7.5. Cash Dividends. Cash dividends paid on Shares shall be deemed to
have been paid on the Shares allocated to each Participant's Share Account as if
the allocated Shares were actual Shares issued and outstanding on the Dividend
Record Date. An amount equal to the amount of such dividends shall be credited
in Shares to each Share Account as of each Dividend Allocation Date based upon
the average of the high and low prices for Shares on The New York Stock Exchange
on the Divided Allocation Date, or, if Shares are not traded on the Divided
Allocation Date, the next day on which Shares are traded.

         7.6. Capital Adjustments. The number of Shares referred to in Section 6
hereof and the number of Shares allocated to each Share Account shall be
adjusted by the Committee, as it deems appropriate, to reflect stock dividends,
stock splits, reclassifications, spinoffs, and other extraordinary
distributions, as if those Shares were actual Shares.

         7.7. Account Statements. Within a reasonable time following the end of
each calendar year, the Company shall render an annual statement to each
Participant. The annual statement for each Deferred Stock Participant shall
report the number of Shares credited to the Participant's Share Account as of
December 31 of that year. The annual statement for each Deferred Compensation
Participant shall report the dollar amount credited to the

                                      -7-

 
Participant's Deferred Compensation Account as of December 31 of that year, and,
if the Deferred Compensation Participant elects to invest a Deferred Amount in
Shares pursuant to subsection 5.2 hereof, or if the Deferred Compensation
Participant elects to convert his final account balance under The Lilly
Directors' Deferred Compensation Plan to Shares pursuant to subsection 5.3
hereof, the number of Shares credited to the Participant's Share Account as of
December 31 of that year.

Section 8.  Payment Provisions.

         8.l. Method of Payment. All payments to a Participant (or to a
Participant's Beneficiary) with respect to the Participant's Deferred
Compensation Account shall be paid in cash. Except as provided in Section 8.5,
all payments to a Participant (or to a Participant's Beneficiary) with respect
to the Participant's Share Account shall be paid in Shares, at which time the
Shares shall be issued or transferred on the books of the Company. All Shares to
be transferred hereunder shall be transferred out of treasury shares to the
extent available. Fractional Shares shall not be transferred to a Participant,
provided that in the case of a final payment under the Plan with respect to a
Participant, any fractions remaining in the Participant's Share Account shall be
rounded up to the next whole Share and that number of whole Shares shall be
transferred to the Participant (or, after the Participant's death, to the
Participant's Beneficiary). If Shares are not traded on The New York Stock
Exchange on any day on which a payment of Shares is to be made under the Plan,
then that payment shall be made on the next day on which Shares are traded on
The New York Stock Exchange.

         8.2. Payment Options. Prior to each calendar year, or within 30 days
after becoming a Participant, the Participant shall select a payment election
with respect to the payment of any one or all of the Participant's Individual
Accounts from the following payment elections:

                  (i) a lump sum in January of the calendar year immediately
following the calendar year in which the Participant ceases to be a Director; or

                  (ii) annual (or, in the case of the Deferred Compensation
Account only, monthly) installments over a period of two to ten years commencing
in January of the calendar year following the calendar year during which the
Participant ceases to be a Director.

If the payment option described in paragraph (i), above, has been elected, the
amount of the lump sum with respect to the Participant's Deferred Compensation
Account shall be equal to the amount credited to the Participant's Deferred
Compensation Account as of the December 31 next

                                      -8-

 
preceding the date of the payment, and the amount of the lump sum with respect
to the Participant's Share Account shall be equal to the number of Shares
credited to the Share Account as of the December 31 next preceding the date of
payment. If the payment option described in paragraph (ii), above, has been
elected, the amount of each installment with respect to the Participant's
Deferred Compensation Account shall be equal to the amount credited to the
Participant's Deferred Compensation Account as of the last day of the month next
preceding the date of a monthly installment payment, or the December 31 next
preceding the date of an annual installment payment, divided by the number of
installment payments that have not yet been made. The amount of each installment
with respect to the Participant's Share Account shall be equal to the number of
Shares credited to the Participant's Share Account as of the December 31 next
preceding the date of an annual installment payment, divided by the number of
installment payments that have not yet been made.

         A Participant may elect that his final payment election may control
over all prior payment elections. If the Participant fails to elect a payment
option, the amount credited to the Participant's Individual Account shall be
distributed in a lump sum in accordance with the payment option described in
paragraph (i), above. If the amount credited to a Participant's Deferred
Compensation Account or the value of Shares credited to a Participant's Share
Account is less than $25,000, the Committee, in its sole discretion, may pay out
the amount credited to the Participant's Individual Account in a lump sum.

         8.3. Payment Upon Death. Within a reasonable period of time following
the death of a Participant, the amount credited to a Participant's Deferred
Compensation Account and all of the Shares credited to the Participant's Share
Account shall be paid by the Company in a lump sum to the Participant's
Beneficiary. For purposes of this subsection 8.3, the amount credited to the
Participant's Deferred Compensation Account and the number of Shares credited to
the Participant's Share Account shall be determined as of the date of payment. A
Participant may designate the Beneficiary, in writing, in a form acceptable to
the Committee before the Participant's death. A Participant may, before the
Participant's death, revoke a prior designation of Beneficiary and may also
designate a new Beneficiary without the consent of the previously designated
Beneficiary, provided that such revocation and new designation (if any) are in
writing, in a form acceptable to the Committee, and filed with the Committee
before the Participant's death. If the Participant does not designate a
Beneficiary, or if no designated Beneficiary survives the Participant, any
amount not distributed to the Participant during the Participant's life shall be
paid to the Participant's estate in a lump sum in accordance with this
subsection 8.3.

                                      -9-

 
         8.4. Payment on Unforeseeable Emergency. The Committee may, in its sole
discretion, direct payment to a Participant of all or of any portion of the
Participant's Individual Account balance, notwithstanding an election under
subsection 8.2 above, at any time that it determines that such Participant has
an unforeseeable emergency, and then only to the extent reasonably necessary to
meet the emergency. For purposes of this section, "unforeseeable emergency"
means severe financial hardship to the Participant resulting from a sudden and
unexpected illness or accident of the Participant or of a dependent of the
Participant, loss of the Participant's property due to casualty, or other
similar extraordinary and unforeseeable circumstances arising as a result of
events beyond the control of the Participant. The circumstances that will
constitute an unforeseeable emergency will depend upon the facts of each case,
but, in any case, payment may not be made to the extent that such hardship is,
or may be, relieved --

                  (i)  through reimbursement or compensation by insurance or
otherwise,

                  (ii) by liquidation of the Participant's assets, to the extent
the liquidation of such assets would not itself cause severe financial hardship,
or

                  (iii) by cessation of deferrals under the Plan.

         Examples of what are not considered to be unforeseeable emergencies
include the need to send a Participant's child to college or the desire to
purchase a home.

         8.5. Payment of Cash in Lieu of Shares. If at any time the Committee
shall determine that payment of Shares to a Participant (or a Participant's
Beneficiary) or the ownership or subsequent disposition of such Shares by such
Participant or Beneficiary may violate or conflict with any applicable law or
regulation, the Committee may, in its discretion, pay all or a portion of the
Participant's Share Account in cash. In this case, the amount of cash shall be
determined with reference to the average of the high and low trading price for
Shares on the December 31 next preceding the date of payment, or if Shares are
not traded on that day, the next preceding trading day.

Section 9.  Ownership of Shares.

A Participant shall have no rights as a shareholder of the Company with respect
to any Shares until the Shares are transferred to the Participant on the books
of the Company.

                                      -10-

 
Section 10.  Prohibition Against Transfer.

The right of a Participant to receive payments of Shares and cash under the Plan
may not be transferred except by will or applicable laws of descent and
distribution. A Participant may not assign, sell, pledge, or otherwise transfer
Shares or cash to which he is entitled hereunder prior to transfer or payment
thereof to the Participant.

Section 11.  General Provisions.

         11.1. Director's Rights Unsecured. The Plan is unfunded. The right of
any Participant to receive payments of cash or Shares under the provisions of
the Plan shall be an unsecured claim against the general assets of the Company.

         11.2. Administration. Except as otherwise provided in the Plan, the
Plan shall be administered by the Committee, which shall have the authority to
adopt rules and regulations for carrying out the Plan, and which shall
interpret, construe, and implement the provisions of the Plan.

         11.3. Legal Opinions. The Committee may consult with legal counsel, who
may be counsel for the Company or other counsel, with respect to its obligations
and duties under the Plan, or with respect to any action, proceeding, or any
questions of law, and shall not be liable with respect to any action taken, or
omitted, by it in good faith pursuant to the advice of such counsel.

         11.4. Liability. Any decision made or action taken by the Board of
Directors, the Committee, or any employee of the Company or any of its
subsidiaries, arising out of or in connection with the construction,
administration, interpretation, or effect of the Plan, shall be absolutely
discretionary, and shall be conclusive and binding on all parties. Neither the
Committee nor a member of the Board of Directors and no employee of the Company
or any of its subsidiaries shall be liable for any act or action hereunder,
whether of omission or commission, by any other member or employee or by any
agent to whom duties in connection with the administration of the Plan have been
delegated or, except in circumstances involving bad faith, for anything done or
omitted to be done.

         11.5. Withholding. The Company shall have the right to deduct from all
payments hereunder any taxes required by law to be withheld from such payments.
The recipients of such payments shall bear all taxes on amounts paid under the
Plan to the extent that no taxes are withheld thereon, irrespective of whether
withholding is required.

                                      -11-

 
         11.6. Incapacity. If the Committee determines that any person entitled
to benefits under the Plan is unable to care for his or her affairs because of
illness or accident, any payment due (unless a duly qualified guardian or other
legal representative has been appointed) may be paid for the benefit of such
person to such person's spouse, parent, brother, sister, or other party deemed
by the Committee to have incurred expenses for such person.

         11.7. Inability to Locate. If the Committee is unable to locate a
person to whom a payment is due under the plan for a period of twelve (12)
months, commencing with the first day of the month as of which the payment
becomes payable, the total amount payable to such person shall be forfeited.

         11.8. Legal Holidays. If any day on (or on or before) which action
under the Plan must be taken falls on a Saturday, Sunday, or legal holiday, such
action may be taken on (or on or before) the next succeeding day that is not a
Saturday, Sunday, or legal holiday; provided, that this subsection 11.8 shall
not permit any action that must be taken in one calendar year to be taken in any
subsequent calendar year.

Section 12.  Amendment, Suspension, and Termination.

The Board of Directors shall have the right at any time, and from time to time,
to amend, suspend, or terminate the Plan, provided that no amendment or
termination shall reduce the number of Shares or the cash balance in an
Individual Account, and provided further that the number of Shares allocated
annually pursuant to Section 6 hereof may not be changed more frequently than
every calendar year.

Section 13.  Applicable Law.

The Plan shall be governed by, and construed in accordance with, the laws of the
State of Indiana, except to the extent that such laws are preempted by Federal
law.

Section 14.  Effective Date.

The effective date of this Plan is January 1, 1996. Nothing herein shall
invalidate or adversely affect any previous election, designation, deferral, or
accrual in accordance with the terms of The Lilly Directors' Deferred
Compensation Plan or The Lilly Non-Employee Directors' Deferred Stock Plan that
were in effect prior to the effective date of this Plan.


                                      -12-

 
                                                                Exhibit 10.6

                      Eli Lilly and Company EVA Bonus Plan

               (As amended and restated effective January 1, 1999)


                                    ARTICLE I

                   Bonus Plan Statement of Purpose and Summary

1.1      The purpose of the Plan is to provide a system of bonus compensation
         for selected employees of Eli Lilly and Company and subsidiaries which
         will promote the maximization of shareholder value over the long term,
         by linking performance incentives to increases in shareholder value.
         The Plan ties bonus compensation to Economic Value Added ("EVA"), and
         thereby rewards employees for long-term, sustained improvement in
         shareholder value. The Plan is intended to satisfy the requirements for
         providing "performance-based" compensation under Section 162(m) of the
         Internal Revenue Code.

1.2      EVA will be used as the performance measure of value creation. EVA
         reflects the benefits and costs of capital employment. Employees create
         economic value when the operating profits from a business exceed the
         cost of the capital employed.


                                   ARTICLE II

                          Definitions of Certain Terms

Unless the context requires a different meaning, the following terms shall have
the following meanings:

2.1      "Company" means Eli Lilly and Company and its subsidiaries.

2.2      "Committee" means the Compensation and Management Development
         Committee, the members of which shall be selected by the Board of
         Directors from among its members. Each Committee member shall, at all
         times while serving, satisfy the requirements of an "outside director"
         within the meaning of Section 162(m).

2.3      "Participant" means any employee of the Company designated by the
         Committee as a participant in the Plan with respect to any Plan Year.
         In its discretion, the Committee may designate Participants either on
         an individual basis or by determining that all employees in specified
         job categories, classifications or levels shall be Participants.

2.4      "Plan" means this Eli Lilly and Company EVA Bonus Plan.

2.5      "Plan Year" means the applicable calendar year.

 
2.6      "Retirement" means the cessation of employment upon the attainment of
         at least eighty age and benefit years of service points, as determined
         by the provisions of The Lilly Retirement Plan as amended from time to
         time, assuming eligibility to participate in that plan.

2.7      "Disability" means the time at which a Participant becomes eligible for
         a payment under The Lilly Extended Disability Plan, assuming
         eligibility to participate in that plan.

2.8      "Section 162(m)" means Section 162(m) of the Internal Revenue Code of
         1986, as amended.

2.9      "Section 162(m) Participant" means a Participant who, in the
         determination of the Committee, is or may in the future become a
         "covered employee" under Section 162(m).


                                   ARTICLE III

                        Definition and Components of EVA

The following terms set forth the calculation of EVA and the components of
calculating EVA. The calculation of EVA for a Plan Year is used in determining
the bonuses earned by Participants under the Plan, as set forth in Article IV.

3.1      "Economic Value Added" or "EVA" means the excess NOPAT that remains
         after subtracting the Capital Charge.

3.2      "Net Operating Profit After Tax" or "NOPAT" means the after tax
         operating earnings of the Company for the Plan Year. NOPAT is
         determined by adding net sales plus other net income (excluding
         interest income from operating cash) and subtracting the following:
         cost of goods sold, selling, general and administrative expenses
         (excluding goodwill amortization and interest expense), amortization of
         research and development, taxes (excluding the tax benefit of interest
         expense) and amounts associated with discontinued operations.

3.3      "Capital Charge" means the deemed opportunity cost of employing Capital
         for the Company. The Capital Charge is calculated by multiplying
         Capital times Cost of Capital (C*).

3.4      "Capital" means the net investment employed in the operations of the
         Company produced by operations and financing activities. Capital is
         calculated by adding together current assets (excluding operating
         cash), net property, plant and equipment, gross goodwill, net
         intangibles, other assets, and capitalized research and development,
         and the present value of operating leases, and subtracting the
         following: non-interest bearing liabilities and capital associated with
         discontinued operations.

3.5      "Cost of Capital" or "C*" is the percentage calculated from the
         weighted average of Cost of Debt and Cost of Equity. Cost of Capital
         for each Plan Year is determined by reference to the percentage
         calculated at the end of October of the prior Plan Year.

3.6      "Cost of Debt" capital is the marginal long-term borrowing rate of the
          Company times (one minus the tax rate).

 
3.7      "Cost of Equity" capital is the risk-free rate plus (beta times the
         market risk premium). For this purpose, (i) "risk free rate" is the
         30-year U.S. Treasury Bond rate, (ii) "beta" represents the 5 year
         historical average variation of the Company's earnings versus the S&P
         500, and (iii) "market risk premium" represents the average risk of an
         equity return versus a bond return.


                                   ARTICLE IV

                   Definition and Computation of the EVA Bonus

Bonuses earned under the Plan for a Plan Year are determined based on a
comparison of actual EVA to the "Target EVA" for the year, which is established
as described below to ensure improvement in EVA from year to year. The result of
this comparison is adjusted by a "Leverage Factor" measuring the volatility of
industry returns. The factor produced is referred to as the "Bonus Multiple,"
which is multiplied by the Participant's "Target Bonus" amount established for
the year to produce the actual bonus earned. This amount, referred to as the
"Declared Bonus," is credited to the Participant's "Bonus Bank" balance and paid
out in the manner provided below.

4.1      Target Bonus. The Target Bonus Awards will be determined by the
         Committee on a basis that takes into consideration a Participant's
         salary grade level, job responsibilities as well as past and expected
         future job performance. Target Bonus Awards are expressed as a
         percentage of annual base salary as in effect on the first day of the
         Plan Year. If a Participant moves from any salary grade level to a G-6
         or above salary grade level during a Plan Year, he/she will receive an
         award that is pro-rated according to time based on the Target Bonus
         percentage and base salary applicable to each such salary grade. The
         Target Bonus will be based on the currency in which the highest portion
         of base pay is regularly paid. The Committee shall determine the
         appropriate foreign exchange conversion methodology in its discretion.

4.2      Declared Bonus.  A Declared Bonus is the Target Bonus times the Bonus
         Multiple.

4.3      Bonus Multiple. The Bonus Multiple is the difference (positive or
         negative) between Actual EVA and Target EVA, divided by the Leverage
         Factor, plus one.

4.4      Bonus Bank. All bonus payments are made from the Bonus Bank. Each
         Participant's beginning Bonus Bank balance in his/her first year of
         participation is zero. The Bonus Bank is increased or decreased for any
         plan year by the amount of Declared Bonus. If the available Bonus Bank
         balance is positive, the Participant will be paid from such balance up
         to the Target Bonus amount, plus one third of any such balance that
         remains after subtracting the Target Bonus from the available Bonus
         Bank balance. If the available Bonus Bank balance is negative, no
         payment will occur.

4.5      Target EVA. The Target EVA for each year will be calculated as follows:

         Target EVA = Prior Year's Actual EVA + Expected Improvement

 
4.6      Expected Improvement. The Expected Improvement is the additional EVA
         amount determined by the Committee that is used to assure that a
         minimum level of improvement is achieved in order to earn target
         awards.

4.7      Leverage Factor. The Leverage Factor determines the rate of change in
         bonuses as EVA surpasses or falls short of Target EVA, determined by
         the Committee from an evaluation of the long term volatility of
         industry returns.

4.8      Section 162(m) Requirements, Bonus Maximum. In the case of Section
         162(m) Participants, all determinations necessary for computing
         Declared Bonuses for a Plan Year, including establishment of all
         components of the EVA calculation and of the Target Bonus percentages,
         shall be made by the Committee not later than 90 days after the
         commencement of the Plan Year. As and to the extent required by Section
         162(m), the terms of a Declared Bonus for a Section 162(m) Participant
         must state, in terms of an objective formula or standard, the method of
         computing the amount of compensation payable to the Section 162(m)
         Participant, and must preclude discretion to increase the amount of
         compensation payable that would otherwise be due under the terms of the
         award. Notwithstanding anything elsewhere in the Plan to the contrary,
         the maximum amount of the Declared Bonus that may be paid from the
         Bonus Bank to a Section 162(m) Participant during any one calendar year
         shall be $5 million.


                                    ARTICLE V

                               Plan Administration

5.1      Time of Payment.  Payment from the Bonus Bank will be made before March
         1 of the year following the Plan Year.

5.2      Certification of Results. Before any amount is paid under the Plan, the
         Committee shall certify in writing the calculation of EVA for the Plan
         Year and the satisfaction of all other material terms of the
         calculation of the Declared Bonus.

5.3      New Hires, Promotions. New hires or individuals promoted who are first
         selected for participation by the Committee effective on a date other
         than January 1 will participate on a pro-rata basis in their first year
         of participation, based on the Declared Bonus determined for the Plan
         Year, pro-rated for that period of the year during which the
         Participant was selected for participation in the Plan. Any such
         Participant's Target Bonus Award will be determined based on his or her
         annual base salary as in effect on the date of hire or promotion, as
         applicable Notwithstanding the foregoing, in the case of any Section
         162(m) Participant who first becomes eligible to participate in the
         Plan after January 1 of a Plan Year, such Participant's Declared Bonus
         may be determined, at the discretion of the Committee exercised at the
         time such participation begins, in a manner that complies with the
         requirements for "performance-based compensation" under Section 162(m).

5.4      Termination of Employment, Demotions. If a Participant ceases
         employment with the Company before the end of a Plan Year for reasons
         other than Retirement, Disability or death, or is demoted to a
         non-global job level with the Company during a Plan Year, the
         Participant shall receive no Declared Bonus for that Plan Year, and
         his/her Bank Balance

 
         shall be forfeited. The Committee may make complete or partial
         exceptions to this rule, in its sole discretion, and, with respect to
         employees other than executive officers, may delegate to the vice
         president responsible for human resources the authority to make such
         exceptions. Notwithstanding the foregoing, with respect to the Declared
         Bonus for a Section 162(m) Participant, any such termination of
         employment or demotion shall result in payment of a bonus based on the
         Declared Bonus determined for the Plan Year but pro-rated for the
         period of the year prior to such event, subject to the Committee's
         discretion to forfeit all or any portion of such bonus.

5.5      Leave of Absence. If a Participant takes an approved leave of absence
         from employment during a Plan Year, the Participant will not be
         eligible for the Declared Bonus for the Plan Year. The Committee may
         make complete or partial exceptions to this rule, in whatever manner it
         deems appropriate, and, with respect to employees other than executive
         officers, may delegate to the vice president responsible for human
         resources the authority to make such exceptions. The Participant will
         retain his Bonus Bank balance if he returns to employment following the
         period of leave of absence. Notwithstanding the foregoing, with respect
         to the Declared Bonus for a Section 162(m) Participant, any such leave
         of absence shall result in payment of a bonus based on the Declared
         Bonus determined for the Plan Year but pro-rated for the period of the
         year that the Participant was actively employed by the Company, subject
         to the Committee's discretion to forfeit all or any portion of such
         bonus.

5.6      Retirement, Disability or Death. If a Participant ceases employment
         with the Company because of Retirement, Disability or death, the
         Participant or personal representative, as the case may be, shall
         receive full payment of his/her Bank Balance and a bonus based on the
         Declared Bonus determined for the Plan Year but pro-rated for that
         period of the Plan Year during which the Participant was an active
         employee of the Company.

5.7      Plan Participation. A Participant may not participate in this Plan for
         any portion of a Plan Year for which he/she is entitled to receive
         payment under the Eli Lilly and Company Contingent Compensation Plan,
         and shall be treated in accordance with 5.3.

5.8      Forfeiture Events. Notwithstanding any other provision of this Plan to
         the contrary, the Committee may, in its sole discretion, upon the
         occurrence of a Forfeiture Event (as defined below), forfeit all or any
         portion of a Participant's Declared Bonus and Bonus Bank balance and
         terminate such Participant's future participation in the Plan. For
         purposes hereof, a "Forfeiture Event" shall mean the occurrence of one
         or more of the following events with respect to a Participant: (i) the
         termination or forced resignation from employment of the Participant
         for "misconduct" (as defined in the Company's Employee Information
         Handbook), (ii) any violation by the Participant of the Guidelines of
         Company Policy (the "Redbook") that is detrimental to the Company,
         (iii) any breach of a noncompetition, nonsolicitation, nondisclosure or
         other restrictive covenant that may apply by written agreement between
         the Company and the Participant or (iv) Participant's having engaged in
         any other activity that, in the judgment of the Committee, is
         detrimental to the business, affairs or reputation of the Company
         (including, without limitation, engaging in any criminal activity).
         Except with respect to executive officers, the Committee may delegate
         the authority granted under this section to the vice president
         responsible for human resources.

 
                                   ARTICLE VI

                               General Provisions

6.1      Withholding of Taxes. The Company shall have the right to withhold the
         amount of taxes which in the sole determination of the Company are
         required to be withheld under law with respect to any amount due or
         payable under the Plan.

6.2      Expenses. All expenses and costs in connection with the adoption and
         administration of the Plan shall be borne by the Company.

6.3      No Prior Right or Offer, No Right to Future Participation.
         Participation in the Plan for Plan Years is determined from
         year-to-year by the Committee in its sole discretion. Except and until
         expressly granted pursuant to the Plan, nothing in the Plan shall be
         deemed to give any employee any contractual or other right to
         participate in the benefits of the Plan. No award to any such
         Participant in any Plan Year shall be deemed to create a right to
         receive any award or to participate in the benefits of the Plan in any
         subsequent Plan Year.

6.4      Rights Personal to Employee. Any rights provided to an employee under
         the Plan shall be personal to such employee, shall not be transferable,
         except by will or pursuant to the laws of descent or distribution, and
         shall be exercisable during his/her lifetime, only by such employee, or
         a court-appointed guardian for the employee.

6.5      Non-Allocation of Award. In the event of a suspension of the Plan in
         any Plan Year, as described in Section 11.1, no awards under the Plan
         for the Plan Year during which such suspension occurs shall affect the
         calculation of awards for any subsequent period in which the Plan is
         continued.


                                   ARTICLE VII

                                   Limitations

7.1      No Continued Employment. Neither the establishment of the Plan nor the
         grant of an award thereunder shall be deemed to constitute an express
         or implied contract of employment of any Participant for any period of
         time or in any way abridge the rights of the Company to determine the
         terms and conditions of employment or to terminate the employment of
         any employee with or without notice or cause at any time.

7.2      No Vested Rights. Except as expressly provided herein, no employee or
         other person shall have any claim of right (legal, equitable, or
         otherwise) to any award, allocation, or distribution or any right,
         title, or vested interest in any amounts in his/her Bonus Bank and no
         officer or employee of the Company or any other person shall have any
         authority to make representations or agreements to the contrary. No
         interest conferred herein to a Participant shall be assignable or
         subject to claim by a Participant's creditors.

7.3      Non-alienation. Except as provided in Subsection 5.1, no Participant or
         other person shall have any right or power, by draft, assignment, or
         otherwise, to mortgage, pledge or

 
         otherwise encumber in advance any payment under the Plan, and every
         attempted draft, assignment, or other disposition thereof shall be
         absolutely void.


                                  ARTICLE VIII

                               Committee Authority

8.1      Authority to Interpret and Administer. Except as otherwise expressly
         provided herein, full power and authority to interpret and administer
         this Plan shall be vested in the Committee. The Committee may from time
         to time make such decisions and adopt such rules and regulations for
         implementing the Plan as it deems appropriate for any Participant under
         the Plan. Except as to Participants who are treated by the Company as
         executive officers of the Company for federal securities law reporting
         purposes (including any Section 162(m) Participant), the Committee may
         delegate in writing to officers or employees of the Company the power
         and authority granted by this Section 8.1 to interpret and administer
         this Plan. Any decision taken by the Committee or officer or employee
         to whom authority has been delegated, arising out of or in connection
         with the construction, administration, interpretation and effect of the
         Plan shall be final, conclusive and binding upon all Participants and
         any person claiming under or through Participants.

8.2      Adjustments for Significant Events. Prior to the beginning of a Plan
         Year, the Committee may specify with respect to Declared Bonuses for
         the Plan Year that EVA will be determined before the effects of
         acquisitions, divestitures, restructurings or changes in corporate
         capitalization, accounting changes, and/or events that are treated as
         extraordinary items for accounting purposes; provided that such
         adjustments shall be made only to the extent permitted by Section
         162(m) in the case of Section 162(m) Participants.

8.3      Financial And Accounting Terms. Except as otherwise provided, financial
         and accounting terms, including terms defined herein, shall be
         determined by the Committee in accordance with generally accepted
         accounting principles and as derived from the audited consolidated
         financial statements of the Company, prepared in the ordinary course of
         business.

8.4      Section 162(m) Deferrals. To the extent that, notwithstanding the terms
         of the Plan, the Company's tax deduction for remuneration in respect of
         the payment of bonuses under the Plan to a Section 162(m) Participant
         would be disallowed under Section 162(m) by reason of the fact that
         such Participant's applicable employee remuneration, as defined in
         Section 162(m), either exceeds or, if such bonus were paid, would
         exceed the $1,000,000 limitation in Section 162(m), any such excess (as
         determined by the Committee in its sole discretion) shall be
         automatically deferred under the terms of The Lilly Deferred
         Compensation Plan. Payment of any deferred amounts shall be made to the
         Participant in the first year thereafter that the Company's tax
         deduction in respect of the payment would not be disallowed under
         Section 162(m).

 
                                   ARTICLE IX

                                     Notice

9.1      Any notice to be given to the Company or Committee pursuant to the
         provisions of the Plan shall be in writing and directed to Secretary,
         Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285.


                                    ARTICLE X

                                 Effective Date

10.1     This Plan, as amended and restated herein, shall be effective for the
         Plan Year commencing January 1, 1999, subject to the approval of the
         Plan at the Company's 1998 annual meeting of stockholders. The terms of
         this restated plan shall apply to Declared Bonuses earned in 1999 and
         future years. All Declared Bonuses earned in years prior to 1999 shall
         be payable in accordance with the terms of the Plan as in effect for
         the year to which the Declared Bonus relates. The final Plan Year of
         this Plan, unless amended by the Board (or the Committee) and approved
         by the stockholders as provided in Article XI, shall be the 2002 Plan
         Year.


                                   ARTICLE XI

                           Amendments and Termination

11.1     This Plan may be amended, suspended or terminated at any time at the
         discretion of the Board of Directors of Eli Lilly and Company, and may,
         except for this Section 11.1, be amended at any time by the Committee.
         Solely to the extent deemed necessary or advisable by the Board (or the
         Committee) for purposes of complying with Section 162(m), the Board (or
         the Committee) may seek the approval of any such amendment by the
         Company's stockholders. Any such approval shall be by the affirmative
         votes of the stockholders of the Company present, or represented, and
         entitled to vote at a meeting duly held in accordance with applicable
         state law and the Articles of Incorporation and By-Laws of the Company.
         The material terms of EVA must be disclosed to and reapproved by the
         stockholders of the Company no later than the Company's annual meeting
         of stockholders that occurs in the year 2003.


                                   ARTICLE XII

                                 Applicable Law

12.1     This Plan shall be governed by and construed in accordance with the
         provisions of the laws of the State of Indiana without regard to the
         conflicts-of-law principles of Indiana.


                                                                    EXHIBIT 10.7

                             ELI LILLY AND COMPANY

                     CHANGE IN CONTROL SEVERANCE PAY PLAN
                             FOR SELECT EMPLOYEES

     1.   PURPOSE

          This Eli Lilly and Company Change in Control Severance Pay Plan For
Select Employees has been established by the Company to provide for the payment
of severance pay and benefits to Eligible Employees whose employment with a
Participating Employer terminates due to certain conditions created by a Change
in Control of the Company. The purpose of the Plan is to assure a continuity in
operations of the Company during a period of Change in Control by allowing
employees to focus on their responsibilities to the Company knowing that they
have certain financial security in the event of their termination of employment.
The accomplishment of this purpose is in the best interests of the Company and
its shareholders.

     2.   DEFINITIONS

          The terms defined in this Section 2 shall have the meanings given
          below:

     (a)  "Annual Base Salary" means the amount of the Eligible Employee's
          Monthly Base Salary multiplied by twelve (12).

     (b)  "Board" means the Board of Directors of the Company.

     (c)  "Change in Control" has the meaning given in Section 3.

     (d)  "Code" means the Internal Revenue Code of 1986, as amended.

     (e)  "Committee" means the Compensation and Management Development
          Committee of the Board, or such other committee appointed by the Board
          to perform the functions of the Committee under the Plan, provided
          that at all times the Committee shall be constituted solely of
          directors who are Continuing Directors (as defined in Section 3) to
          the extent any such directors remain on the Board and are willing to
          serve in such capacity.

     (f)  "Covered Termination" has the meaning given in Section 6.

     (g)  "Company" means Eli Lilly and Company, an Indiana corporation.

     (h)  "Eligible Employee" means a Tier I Employee or a Tier II Employee.

     (i)  "ERISA" means the Employee Retirement Income Security Act of 1974, as
          amended.

     (j)  "Exchange Act" means the Securities Exchange Act of 1934, as amended.

     (k)  "Monthly Base Salary" means an Eligible Employee's gross monthly base
          salary before any deductions, exclusions or any deferrals or
          contributions under any Participating Employer plan or 

 
          program, but excluding bonuses, incentive awards or compensation,
          employee benefits or any other non-salary form of compensation.

     (l)  "Participating Employer" has the meaning given in Section 4.

     (m)  "Plan" means this Eli Lilly and Company Change in Control Severance
          Pay Plan for Select Employees.

     (n)  "Severance Multiple" means the number of years represented by the
          Severance Period for the Eligible Employee.

     (o)  "Severance Period" means (i) in the case of Tier I Employees, the
          three (3) year period immediately following a Covered Termination and
          (ii) in the case of Tier II Employees, the two (2) year period
          immediately following a Covered Termination.

     (p)  "Tier I Employees" and "Tier II Employees" have the meanings given in
          Section 5.

     3.   CHANGE IN CONTROL

          For purposes of the Plan, a "Change in Control" of the Company shall
be deemed to have occurred upon:

          (a)  the acquisition by any "person," as that term is used in Sections
     13(d) and 14(d) of the Exchange Act (other than (i) the Company, (ii) any
     subsidiary of the Company, (iii) any employee benefit plan or employee
     stock plan of the Company or a subsidiary of the Company or any trustee or
     fiduciary with respect to any such plan when acting in that capacity, or
     (iv) Lilly Endowment, Inc.) of "beneficial ownership," as defined in Rule
     13d-3 under the Exchange Act, directly or indirectly, of 15% or more of the
     shares of the Company's capital stock the holders of which have general
     voting power under ordinary circumstances to elect at least a majority of
     the Board (or which would have such voting power but for the application of
     the Indiana Control Shares Statute) ("Voting Stock");

          (b)  the first day on which less than two-thirds of the total
     membership of the Board shall be Continuing Directors (as that term is
     defined in Article 13(f) of the Company's Articles of Incorporation);

          (c)  approval by the shareholders of the Company of a merger, share
     exchange, or consolidation of the Company (a "Transaction"), other than a
     transaction which would result in the Voting Stock of the Company
     outstanding immediately prior thereto continuing to represent (either by
     remaining outstanding or by being converted into voting securities of the
     surviving entity) more than 50% of the Voting Stock of the Company or such
     surviving entity immediately after such Transaction;

          (d)  approval by the shareholders of the Company of a complete
     liquidation of the Company or a sale or disposition of all or substantially
     all the assets of the Company, other than a sale or disposition of assets
     to any subsidiary of the Company;

          (e)  either (i) the Company shall have entered into a definitive
     agreement with any Person, which, if consummated, would result in a Change
     in Control as specified in paragraphs (a) through (d) of this Section 3 or
     (ii) any Person initiates a tender offer or exchange offer to acquire
     shares of the Voting Stock which, if consummated, would result in a Change
     in Control as specified in paragraphs (a) through (d) of this Section 3;
     provided, however, that if the Board shall make a final determination that
     such agreement, tender offer or exchange offer will not be consummated, the
     occurrence of any such event shall cease to constitute a

                                       2

 
     Change in Control and the termination of employment of an Eligible Employee
     after such determination shall not be treated as a Covered Termination on
     the basis of such event; or

          (f)  the Board adopts a resolution to the effect that any Person has
     taken actions which, if consummated, would result in its having acquired
     effective control of the business and affairs of the Company; provided,
     however, that if the Board shall make a final determination that such
     actions will not be consummated, the occurrence of any such event shall
     cease to constitute a Change in Control and the termination of employment
     of an Eligible Employee after such determination shall not be treated as a
     Covered Termination on the basis of such event.

For purposes of this Section 3 only, the term "subsidiary" means a corporation
of which the Company owns directly or indirectly fifty (50) percent or more of
the voting power.


     4.   PARTICIPATING EMPLOYERS

          A.   Designation of Participating Employers. The Company and each
subsidiary corporation of which the Company owns directly or indirectly one-
hundred (100) percent of the voting power at the time of the Change in Control
shall be Participating Employers under the Plan. In addition, the Committee may
designate other affiliates of the Company as Participating Employers under the
Plan, from time to time and under such terms and conditions, as shall be
specified by an action in writing by the Committee. Such terms and conditions
may impose limitations on the extent to which any such affiliate participates in
the Plan (including but not limited to the duration of any such participation),
but shall not provide rights or benefits to Eligible Employees that are broader
than those set forth in the Plan. Any entity that is a Participating Employer at
the time of a Change in Control shall continue to be a Participating Employer
following a Change in Control, and any person, firm or business that is a
successor to the business or interests of a Participating Employer following a
Change in Control shall be treated as a Participating Employer under the Plan.

          B.   Limitations in Foreign Jurisdictions. Notwithstanding the
foregoing or anything elsewhere in the Plan to the contrary, the Committee shall
have the discretionary authority, as specified below, to exclude from
participation or limit the participation of any Participating Employer with
respect to its Eligible Employees employed outside of the United States. The
Committee shall exercise this authority only by an action in writing taken prior
to a Change in Control on the basis of a good faith determination that, as a
result of the specific effect of applicable local law or practice with respect
to the Plan, it would be in the best interests of the Company to so exclude or
limit such participation. In addition, to the extent specified by an action in
writing prior to a Change in Control, the Committee may offset the benefits
provided under the Plan to any such Eligible Employee by benefits under
severance arrangements that exist by reason of applicable local law or practice.

     5.   ELIGIBLE EMPLOYEES

          The following individuals shall be eligible to participate in the Plan
and shall be considered an Eligible Employee for all purposes hereunder:

          (i)  "Tier I Employees" - the Chief Executive Officer of the Company
     immediately prior to the Change in Control, and all members of the
     Operations Committee (or a successor committee) of the Company appointed by
     the Chief Executive Officer, as constituted immediately prior to the Change
     in Control; and

          (ii) "Tier II Employees" - all employees of the Participating
     Employers (other than Tier I Employees) who are classified by the Company
     as Executive Directors or above (or any successor classifications)
     immediately prior to the Change in Control.

                                       3

 
Any person who is an Eligible Employee in accordance with the foregoing shall
continue to be an Eligible Employee (and shall retain his/her status as a Tier I
or Tier II Employee for purposes of the Plan) notwithstanding any change in
his/her position or classification following a Change in Control. The Committee
shall notify each Eligible Employee of his/her participation in the Plan and
status as a Tier I or Tier II Employee at the time of the Change in Control.


     6.   COVERED TERMINATIONS

          A.   General.  An Eligible Employee shall be treated as having
suffered a "Covered Termination" hereunder under the following circumstances:

               1.   Tier I Employees.  The termination of employment of a Tier I
     Employee shall be treated as a Covered Termination if his/her employment is
     terminated under one of the following circumstances:

          (i)  at anytime within two (2) years following the date of a Change in
     Control, termination of employment by a Participating Employer without
     "Cause" or by the Eligible Employee for "Good Reason"; or

          (ii) beginning with the one (1) year anniversary of the date of a
     Change in Control and for a period of thirty (30) calendar days thereafter,
     termination of employment by a Participating Employer without "Cause" or by
     the Eligible Employee for any reason (whether or not for "Good Reason").

               2.   Tier II Employees.  The termination of employment of a Tier
     II Employee shall be treated as a Covered Termination if his/her employment
     is terminated, within a period of two (2) years following the date of a
     Change in Control, by a Participating Employer other than for "Cause" or by
     the Eligible Employee for "Good Reason."

For purposes of the foregoing, the time periods specified above within which a
termination of employment may be treated as a Covered Termination shall commence
on the date the Change in Control becomes effective and, with respect to a
Change in Control under paragraphs (e) and (f) of Section 3, shall recommence
(for the full applicable period) on the date of consummation of the underlying
actions; provided, however, that in the event of a Change in Control under
paragraphs (e) and (f) of Section 3, the time period within which a Covered
Termination under clause (ii) of paragraph 1 above may occur shall be measured
only from the date of consummation of the underlying actions (and not from any
earlier date).

          An Eligible Employee shall not be treated as having suffered a Covered
Termination in the event of his/her death, total disability (within the meaning
of the Company's Extended Disability Plan), transfer of employment among
Participating Employers (unless such transfer gives rise to a "Good Reason") or
involuntary termination for "Cause."

          B.   Termination For Cause.  For purposes hereof, the termination of
an Eligible Employee's employment shall be deemed to be a termination for
"Cause" if as a result of:

          (i)  the willful refusal of the Eligible Employee to perform, without
     legal cause, his/her material duties to the Participating Employer,
     resulting in demonstrable economic harm to any Participating Employer,
     which the Eligible Employee has failed to cure after thirty (30) calendar
     days' advance written notice from the Company; or

          (ii) the conviction of the Eligible Employee by a court of competent
     jurisdiction of any crime (or enters a plea of guilty or nolo contendere to
     a charge of any crime) constituting a felony.


                                       4

 
          C.   Termination for Good Reason.  For purposes hereof, an Eligible
Employee may terminate his/her employment for "Good Reason" as a result of:

          (i)  a material diminution in the nature or status of the Eligible
     Employee's position, title, reporting relationship, duties,
     responsibilities or authority, or the assignment to him/her of additional
     responsibilities that materially increase his/her workload;

          (ii) any reduction in the Eligible Employee's then-current Monthly
     Base Salary;

          (iii) a material reduction in the Eligible Employee's opportunities to
     earn incentive bonuses below those in effect for the year most recently
     completed before the date of the Change in Control, taking into account all
     material bonus factors such as targeted bonus amounts and corporate
     performance measures;

          (iv) a material reduction in the Eligible Employee's employee benefits
     and coverages (including, without limitation, pension, profit sharing and
     all welfare and fringe benefits) that are provided to the Eligible Employee
     from the benefit levels in effect immediately prior to the Change in
     Control;

          (v)  the failure to grant to the Eligible Employee stock options,
     performance shares or similar equity incentive rights during each twelve
     (12) month period following the Change in Control on the basis of a number
     of shares or units and all other material terms (including vesting
     requirements) at least as favorable to the Eligible Employee as those
     rights granted to him/her on an annualized average basis for the three (3)
     year period immediately prior to the Change in Control; or

          (vi) relocation of the Eligible Employee by more than fifty (50) miles
     from his/her regularly assigned workplace existing on the date of the
     Change in Control.


     7.   SEVERANCE PAYMENT

          The amount of the severance payment to be received by an Eligible
Employee whose employment is terminated under conditions constituting a Covered
Termination shall equal the applicable Severance Multiple for the Eligible
Employee multiplied by the sum of:

          (i)  the Eligible Employee's Annual Base Salary at the time of Covered
     Termination (calculated without regard to any reduction in Monthly Base
     Salary that results in a Good Reason termination) or, if greater, at the
     time of the Change in Control, plus

          (ii) the greater of (a) the amount of the Eligible Employee's target
     incentive bonus for the year of Covered Termination or (b) the amount of
     the Eligible Employee's incentive bonus earned for the year immediately
     prior to the Change in Control.

          The severance payment to be made hereunder shall be paid to the
Eligible Employee in a single lump-sum cash payment, net of any required tax
withholding, within fifteen (15) calendar days after the date of the Eligible
Employee's Covered Termination. Any payment required under this Section 7 or any
other provision of the Plan that is not made in a timely manner shall bear
interest at a rate equal to one hundred twenty (120) percent of the monthly
compounded applicable federal rate, as in effect under Section 1274(d) of the
Code for the month in which the payment is required to be made.


                                       5

 
     8.   OTHER SEVERANCE BENEFITS

          In addition to the severance payment provided under Section 7, an
Eligible Employee shall be entitled to the following benefits and other rights
in the event of his/her Covered Termination:

          A.   Welfare Benefits.  The Eligible Employee shall be entitled to
continued coverage and benefits for the duration of the applicable Severance
Period, at the Company's sole expense for coverage, under all employee welfare
benefit plans (including, without limitation, medical, dental, group life, death
benefit, dependent life, supplemental life, accidental death and dismemberment,
short-term disability and long-term disability plans, health care reimbursement
account and dependent day care reimbursement account) of a Participating
Employer for which he/she was eligible at the time of Covered Termination or, if
it would provide benefit coverages more favorable to the Eligible Employee, at
the time of the Change in Control, as though his/her termination of employment
had not occurred (the "Welfare Continuation Coverages"). All Welfare
Continuation Coverages shall apply to the Eligible Employee and any of his/her
dependents who would have been eligible for coverage if the Eligible Employee
remained employed for the applicable Severance Period. The Company may provide
the Eligible Employee with the Welfare Continuation Coverages under arrangements
other than its generally applicable welfare benefit plans, provided that the
benefit coverages so provided are at least as favorable to the Eligible Employee
as coverage under the otherwise applicable Welfare Continuation Coverages, on a
coverage by coverage basis, and taking into account all tax consequences to the
Eligible Employee. At the expiration of the applicable Severance Period, the
Eligible Employee shall be treated as a then terminating employee with respect
to the right to elect continued medical and dental coverages in accordance with
Section 4980B of the Code (or any successor provision thereto).

          B.   Pension Supplement.  The Eligible Employee shall be entitled to
the additional pension benefits that would be payable to him/her, under all
defined benefit pension plans of a Participating Employer in which he/she is
participating at the time of Covered Termination (including all such tax-
qualified and supplemental plans), by taking into account under such plans (i)
an additional number of years equal to the Severance Period applicable to the
Eligible Employee for purposes of the age and service credit of the Eligible
Employee under such plans and (ii) the amount of the severance payment to which
the Eligible Employee is entitled under Section 7, expressed on an annualized
basis for the number of years equal to the Severance Period applicable to the
Eligible Employee, for purposes of the compensation credit of the Eligible
Employee under such plans (but only to the extent such additional credit would
produce a higher benefit for the Eligible Employee than if it were not taken
into account). The additional pension benefits provided hereby shall be paid
pursuant to a supplemental pension plan of the Company, at the same time and in
the same form as pension benefits are otherwise payable to the Eligible Employee
(subject to clause (iii) of Section 8.D).

          C.   Equity Incentives.  Immediately upon a Covered Termination, (i)
any stock options or similar equity-based incentive rights granted to the
Eligible Employee under a stock incentive plan of a Participating Employer that
are not then fully vested and exercisable shall become fully vested and
immediately exercisable and the Eligible Employee shall be entitled to exercise
any such rights until the expiration of their original full term (without regard
to any earlier termination otherwise applicable in the event of termination of
employment), and (ii) any performance shares or shares of restricted stock
granted to the Eligible Employee under a stock incentive plan of a Participating
Employer that remain subject to forfeiture, performance conditions or transfer
restrictions at such time shall become fully and immediately vested and all such
conditions and restrictions shall immediately lapse. In addition, as to any
other types of equity-based incentive awards granted to the Eligible Employee
under a stock incentive plan of a Participating Employer prior to the date of
Covered Termination, any restrictions on exercise, payment or transfer shall
immediately lapse, and the Eligible Employee shall have all rights associated
with such awards as of the date of Covered Termination. Notwithstanding the
foregoing, the rights provided by this Section 8.C shall not apply with respect
to an Eligible Employee who is subject to Section 16 of the Exchange Act to the
extent that any such rights could not be made available under the terms of a
stock incentive plan of a Participating Employer, unless such plan could be
amended to make such rights available without any requirement for shareholder
approval for such plan to continue to meet the requirements for exemption of
Rule 16b-3 under the Exchange Act. The provisions of this Section 8.C shall


                                       6

 
apply equally to any awards or rights into which the equity incentive rights
described herein are converted or for which such rights are substituted in
connection with a Change in Control.

          D.   Accrued Rights.  The Eligible Employee shall be entitled to the
following payments and benefits in respect of accrued compensation rights at the
time of a Covered Termination, in addition to all other rights provided under
the Plan: (i) immediate payment of any accrued but unpaid Annual Base Salary
through the date of Covered Termination; (ii) payment within fifteen (15)
calendar days of Covered Termination of the accrued bonus for the year in effect
on the date of the Covered Termination, determined on the basis of the bonus
earned under terms of the applicable bonus plan through the date of termination
or, if greater, the pro-rata amount of the target bonus for the period of such
year through the date of termination; (iii) payment within fifteen (15) calendar
days of Covered Termination of all non-tax-qualified deferred compensation
rights, in lieu of payment in respect of such rights that would otherwise be
made at a later date in accordance with the terms of such arrangements, except
to the extent such rights are funded by amounts held under an irrevocable
grantor trust or other irrevocable commitment of funds by the Company; and (iv)
all benefits and rights accrued under the employee benefit plans, fringe benefit
programs and payroll practices of a Participating Employer (other than those
described in clause (iii) above) in accordance with their terms (including,
without limitation, employee pension, employee welfare, incentive bonus and
stock incentive plans).

          E.   Outplacement; Relocation.  The Eligible Employee shall be
provided, at the Company's sole expense, with professional outplacement services
selected by the Eligible Employee consistent with his/her duties or profession
and of a type and level customary for persons in his/her position; provided,
however, that the Company shall not be required to pay fees in connection with
the foregoing in an amount greater than fifteen (15) percent of the Eligible
Employee's Annual Base Salary for purposes of clause (i) of Section 7. The
Company shall honor any prior agreement or understanding with an Eligible
Employee who has suffered a Covered Termination to reimburse his/her relocation
expenses to the Indianapolis, Indiana metropolitan area or, if it does not
result in a greater cost to the Company, to such other location selected by the
Eligible Employee.

          F.   Indemnification.  With respect to any Eligible Employee who is,
immediately prior to a Change in Control or a Covered Termination, indemnified
by the Company for his/her service as a director, officer or employee of a
Participating Employer, the Company shall indemnify such Eligible Employee to
the fullest extent permitted by applicable law, and the Company shall maintain
in full force and effect, for the duration of all applicable statute of
limitation periods, insurance policies at least as favorable to the Eligible
Employee as those maintained by the Company for the benefit of its directors and
officers at the time of Change in Control, with respect to all costs, charges
and expenses whatsoever (including payment of expenses in advance of final
disposition of a proceeding) incurred or sustained by the Eligible Employee in
connection with any action, suit or proceeding to which he/she may be made a
party by reason of being or having been a director, officer or employee of a
Participating Employer or serving or having served any other enterprise as a
director, officer or employee at the request of a Participating Employer.


     9.   EXCISE TAX REIMBURSEMENT

          In the event it shall be determined that any payment or distribution
by the Company or any other person or entity to or for the benefit of an
Eligible Employee who suffers a Covered Termination is a "parachute payment"
within the meaning of Section 280G of the Code, whether paid or payable or
distributed or distributable pursuant to the terms of this Plan or otherwise, or
whether prior to or following the Covered Termination, in connection with, or
arising out of, his/her employment with a Participating Employer or a change in
ownership or effective control of the Company or a substantial portion of its
assets (a "Payment"), and would be subject to the excise tax imposed by Section
4999 of the Code (the "Excise Tax"), concurrent with the making of such Payment,
the Company shall pay to the Eligible Employee an additional payment (the 
"Gross-Up Payment") in an amount such that the net amount retained by the
Eligible Employee, after deduction of any Excise Tax on such Payment and any
federal, state or local income tax and Excise Tax on the Gross-Up Payment shall
equal the amount of such Payment. In the event the Internal Revenue Service
subsequently may assess or seek to assess from the Eligible Employee an amount
of Excise Tax in excess of


                                       7

 
that determined in accordance with the foregoing, the Company shall pay to the
Eligible Employee an additional Gross-Up Payment, calculated as described above
in respect of such excess Excise Tax, including a Gross-Up Payment in respect of
any interest or penalties imposed by the Internal Revenue Service with respect
to such excess Excise Tax.


     10.  NO MITIGATION OR OFFSET

          The Eligible Employee shall be under no obligation to minimize or
mitigate damages by seeking other employment, and the obtaining of any such
other employment shall in no event effect any reduction of the Company's
obligation to make the payments and provide the benefits required under the
Plan. In addition, the Company's obligation to make the payments and provide the
benefits required under the Plan shall not be affected by any circumstances,
including, without limitation, any set-off, counterclaim, recoupment, defense or
other rights which a Participating Employer may have against the Eligible
Employee.


     11.  UNFUNDED STATUS

          The Plan is intended to constitute an employee pension benefit plan
under ERISA which is unfunded and is maintained primarily for the purpose of
providing deferred compensation for a select group of management or highly
compensated employees, and shall be interpreted and administered accordingly.
The payments and benefits provided hereunder shall be paid from the general
assets of the Company. Nothing herein shall be construed to require the Company
to maintain any fund or to segregate any amount for the benefit of any employee,
and no employee or other person shall have any right against, right to, or
security or other interest in any fund, account or asset of the Company from
which the payment pursuant to the Plan may be made. Consistent with the
foregoing, the Company may, in its sole discretion, deposit funds in a grantor
trust or otherwise establish arrangements to pay amounts that become due under
the Plan, and, notwithstanding anything elsewhere in the Plan to the contrary,
the payments and benefits due under the Plan shall be reduced to reflect the
amount of any payment made in respect of any Eligible Employee from a grantor
trust or other arrangement established for this purpose.


     12.  ADMINISTRATION

          The Committee shall be the named fiduciary of the Plan and the plan
administrator for purposes of ERISA. The Committee shall be responsible for the
overall operation of the Plan and shall have the fiduciary responsibility for
the general operation of the Plan. The Committee may allocate to any one or more
of the Company's employees any responsibility the Committee may have under the
Plan and may designate any other person or persons to carry out any of the
Committee's responsibilities under the Plan. As plan administrator, the
Committee shall maintain records pursuant to the Plan's provisions and shall be
responsible for the handling, processing and payment of any claims for benefits
under the Plan.


     13.  CLAIMS AND DISPUTES

          Within fifteen (15) calendar days of a Covered Termination, the
Company shall notify each Eligible Employee whom the Company determines is
entitled to payments and benefits under the Plan of his/her entitlement to such
payments and benefits. An Eligible Employee who is not so notified may submit a
claim for payments and benefits under the Plan in writing to the Company within
ninety (90) calendar days after becoming entitled to such benefits as described
in Section 6. All such claims shall be approved or denied in writing by the
Company within fifteen (15) calendar days after submission.


                                       8

 
          Any denial of a claim by the Company shall be in writing and shall
include: (i) the reason or reasons for the denial; (ii) reference to the
pertinent Plan provisions on which the denial is based; (iii) a description of
any additional material or information necessary for the Eligible Employee to
perfect the claim together with an explanation of why the material or
information is necessary; and (iv) an explanation of the Plan's claim review
procedure, described below.

          An Eligible Employee shall have a reasonable opportunity to appeal a
denied claim to the Company for a full and fair review. The Eligible Employee or
authorized representative shall have sixty (60) calendar days after receipt of
written notification of the denial of claim in which to request a review and to
review pertinent documents of the Plan. The Company shall notify the Eligible
Employee or his/her authorized representative of the time and place for the
claim review. The Company shall issue a decision on the reviewed claim promptly,
but no later than fifteen (15) calendar days after receipt of the request for
review. The Company's decision shall be in writing and shall include: (i) the
reasons for the decision, and (ii) references to the Plan provisions on which
the decision is based.

          If the Eligible Employee shall dispute the Company's final decision,
the dispute shall be submitted to an arbitration proceeding, conducted before a
panel of three arbitrators, in accordance with the rules of the Center for
Public Resources (or such other organization selected by mutual agreement of the
Company and the Eligible Employee). Such arbitration shall take place in the
location most practicably proximate to the Eligible Employee's principal
workplace. Judgment may be entered on the arbitrators' award in any court having
jurisdiction. Notwithstanding the foregoing, if an Eligible Employee believes
the claims procedure or dispute resolution mechanism provided under this Section
13 would be futile or would cause such Eligible Employee irreparable harm, the
Eligible Employee may, in his/her sole discretion, elect to enforce his/her
rights under the Plan pursuant to Section 502 of ERISA.

          The Company shall bear the expense of any enforcement proceeding
brought by an Eligible Employee under the Plan and shall reimburse the Eligible
Employee for all of his/her reasonable costs and expenses relating to such
enforcement proceeding, including, without limitation, reasonable attorneys'
fees and expenses, provided that the Eligible Employee is the prevailing party
in such proceeding. For purposes hereof, the trier of fact in such enforcement
proceeding shall be requested to make a determination as to the reimbursement of
the Eligible Employee's costs and expenses as a prevailing party hereunder. In
no event shall the Eligible Employee be required to reimburse the Company for
any of the costs or expenses relating to such enforcement proceeding.

     14.  TERM AND AMENDMENT

     The Plan shall become effective on the date of its adoption by the Board
(the "Effective Date") and shall continue to be effective until the "Expiration
Date." The Expiration Date shall initially be the third anniversary of the
Effective Date, but as of the first anniversary of the Effective Date and each
anniversary date thereafter, the Expiration Date shall be extended by an
additional one (1) year unless, not later than ninety (90) calendar days prior
to the respective anniversary date of the Effective Date, the Board shall
specify by resolution or other written action that the Expiration Date shall not
be so extended. Notwithstanding the foregoing, in the event of a Change in
Control, the Plan shall continue in effect, and the Expiration Date shall not
occur, until the satisfaction of all severance payments and benefits to which
Eligible Employees are or may become entitled to under the Plan. The Board shall
have the right, by resolution or other written action, to amend the Plan;
provided, however, that the Plan may only be amended prior to a Change in
Control, and then only to the extent such amendment is of a technical or
clarifying nature, or increases the rights or benefits of all affected Eligible
Employees, and does not in any manner reduce the rights or benefits of any
Eligible Employee, unless the Company has obtained the express written consent,
in return for good and valuable consideration, of all affected Eligible
Employees in respect of any such amendment.

                                       9

 
     15.  SUCCESSORS AND ASSIGNS

          The Plan shall be binding upon any person, firm or business that is a
successor to the business or interests of the Company, whether as a result of a
Change in Control of the Company or otherwise. All payments and benefits that
become due to an Eligible Employee under the Plan shall inure to the benefit of
his/her heirs, assigns, designees or legal representatives.

     16.  ENFORCEABILITY

          The Company intends the Plan to constitute a legally enforceable
obligation between it and each Eligible Employee, and that the Plan confer
vested rights on each Eligible Employee in accordance with the terms of the
Plan, with each Eligible Employee being a third-party beneficiary thereof.
Nothing in the Plan, however, shall be construed to confer on any Eligible
Employee any right to continue in the employ of a Participating Employer or
affect the right of a Participating Employer to terminate the employment or
change the terms and conditions of employment of an Eligible Employee, with or
without notice or cause, prior to a Change in Control, or to take any such
action following a Change in Control, subject to the consequences specified by
the Plan.

          The Plan shall be construed and enforced in accordance with ERISA and
the laws of the State of Indiana to the extent not preempted by ERISA,
regardless of the law that might otherwise govern under applicable principles or
provisions of choice or conflict of law doctrines. To the extent any provision
of the Plan shall be invalid or unenforceable under any applicable law, it shall
be considered deleted herefrom and all other provisions of the Plan shall be
unaffected and shall continue in full force and effect.

          IN WITNESS WHEREOF, the Board has caused this Plan to be adopted and
executed by its duly authorized representative as of March 1, 1995.


                                  ELI LILLY AND COMPANY



                                  By:
                                      ----------------------------------------
                                      Title: Vice President of Human Resources

Attest:


- --------------------------------

                                      10

 
EXHIBIT 12. STATEMENT RE:  COMPUTATION OF RATIO OF 
EARNINGS FROM CONTINUING OPERATIONS TO FIXED CHARGES                           
(Dollars in Millions)

Years Ended December 31, -------------------------------------------------------------- 1998 1997 1996 1995 1994 -------- -------- -------- -------- -------- Consolidated Pretax Income from Continuing Operations before Extraordinary Item........ $2,665.0 $2,901.1 $2,131.3 $1,866.6 $1,693.3 Interest from Continuing Operations and Other Fixed Charges............. 198.3 253.1 323.8 323.9 128.7 Less Interest Capitalized during the Period from Continuing Operations..... (17.0) (20.4) (35.8) (38.3) (25.4) -------- -------- -------- -------- -------- Earnings..................... $2,846.3 $3,133.8 $2,419.3 $2,152.2 $1,796.6 ======== ======== ======== ======== ======== Fixed Charges/(1)/........... $ 200.5 $ 256.8 $ 328.5 $ 323.9 $ 128.7 ======== ======== ======== ======== ======== Ratio of Earnings to Fixed Charges............. 14.2 12.2 7.4 6.6 14.0 ======== ======== ======== ======== ========
/(1)/ Fixed charges include interest from continuing operations for all years presented and beginning in 1996, preferred stock dividends.

 
EXHIBIT 13. ANNUAL REPORT TO SHAREHOLDERS FOR THE YEAR
            ENDED DECEMBER 31, 1998

 
Consolidated Statements of Income
ELI LILLY AND COMPANY AND SUBSIDIARIES
(Dollars in millions, except per-share data)

Year Ended December 31 1998 1997 1996 - ------------------------------------------------------------------------------------------------------------------------------------ Net sales......................................................... $9,236.8 $ 7,987.7 $6,998.3 Cost of sales..................................................... 2,015.1 1,946.0 1,872.1 Research and development.......................................... 1,738.9 1,370.2 1,189.5 Marketing and administrative...................................... 2,658.3 2,233.1 1,892.4 Acquired in-process technology (Note 4)........................... 127.5 - - Asset impairment (Note 3)......................................... - 97.8 - Gain on sale of DowElanco (Note 4)................................ - (631.8) - Interest expense.................................................. 181.3 232.7 288.0 Other income--net................................................. (149.3) (161.4) (375.0) -------- --------- -------- 6,571.8 5,086.6 4,867.0 -------- --------- -------- Income from continuing operations before income taxes and extraordinary item............................. 2,665.0 2,901.1 2,131.3 Income taxes (Note 11)............................................ 568.7 885.2 505.6 -------- --------- -------- Income from continuing operations before extraordinary item.............................................. 2,096.3 2,015.9 1,625.7 Income (loss) from discontinued operations, net of tax (Note 3)............................................. 8.8 (2,401.0) (102.2) Extraordinary item, net of tax (Note 6)........................... (7.2) - - -------- --------- -------- Net income (loss)................................................. $2,097.9 $ (385.1) $1,523.5 ======== ========= ======== Earnings (loss) per share - basic (Note 10): Income from continuing operations before extraordinary item..................................... $ 1.91 $ 1.83 $ 1.48 Income (loss) from discontinued operations...................... .01 (2.18) (.09) Extraordinary item.............................................. (.01) - - -------- --------- -------- Net income (loss)............................................... $ 1.91 $ (.35) $ 1.39 ======== ========= ======== Earnings (loss) per share - diluted (Note 10): Income from continuing operations before extraordinary item..................................... $ 1.87 $ 1.78 $ 1.45 Income (loss) from discontinued operations...................... .01 (2.12) (.09) Extraordinary item.............................................. (.01) - - -------- --------- -------- Net income (loss)............................................... $ 1.87 $ (.34) $ 1.36 ======== ========= ========
See notes to consolidated financial statements. 1 Consolidated Balance Sheets ELI LILLY AND COMPANY AND SUBSIDIARIES (Dollars in millions)
December 31 1998 1997 - --------------------------------------------------------------------------------------------------------------- Assets Current Assets Cash and cash equivalents.............................................. $ 1,495.7 $ 1,947.5 Short-term investments................................................. 101.4 77.1 Accounts receivable, net of allowances of $64.3 (1998) and $53.3 (1997)....................................... 1,967.9 1,544.3 Other receivables...................................................... 275.8 338.9 Inventories (Note 1)................................................... 999.9 900.7 Deferred income taxes (Note 11)........................................ 332.7 325.7 Prepaid expenses....................................................... 233.4 186.5 --------- --------- Total current assets................................................ 5,406.8 5,320.7 Other Assets Prepaid retirement (Note 12)........................................... 612.3 579.1 Investments (Note 5)................................................... 204.0 465.6 Goodwill and other intangibles, net of allowances for amortization of $171.4 (1998) and $119.3 (1997)................................................... 1,517.9 1,550.5 Sundry................................................................. 758.2 559.8 --------- --------- 3,092.4 3,155.0 Property and Equipment (Note 1)........................................ 4,096.3 4,101.7 --------- --------- $12,595.5 $12,577.4 ========= =========
2 Consolidated Balance Sheets ELI LILLY AND COMPANY AND SUBSIDIARIES (Dollars in millions)
December 31 1998 1997 - ------------------------------------------------------------------------------------------------------------------ Liabilities and Shareholders' Equity Current Liabilities Short-term borrowings (Note 6).............................................. $ 181.4 $ 227.6 Accounts payable............................................................ 1,186.0 985.5 Employee compensation....................................................... 704.0 456.6 Dividends payable........................................................... 252.9 221.7 Income taxes payable (Note 11).............................................. 1,290.2 1,188.0 Other liabilities........................................................... 992.7 1,112.2 --------- --------- Total current liabilities................................................ 4,607.2 4,191.6 Other Liabilities Long-term debt (Note 6)..................................................... 2,185.5 2,326.1 Deferred income taxes (Note 11)............................................. 247.9 215.5 Retiree medical benefit obligation (Note 12)................................ 114.7 118.3 Other noncurrent liabilities................................................ 1,010.6 920.3 --------- --------- 3,558.7 3,580.2 Commitments and contingencies (Note 13)..................................... - - Minority interest in subsidiary (Note 9).................................... - 160.0 Shareholders' Equity (Notes 7 and 8) Common stock--no par value Authorized shares: 3,200,000,000 Issued shares: 1,097,400,814 (1998) and 1,111,521,927 (1997)...................................... 686.5 694.7 Additional paid-in capital.................................................. - - Retained earnings........................................................... 4,228.8 4,497.3 Deferred costs--ESOP........................................................ (146.9) (155.7) Accumulated other comprehensive income (Note 14)............................ (229.8) (281.2) --------- --------- 4,538.6 4,755.1 Less cost of common stock in treasury: 1998 -- 995,492 shares 1997 -- 1,000,000 shares............................................... 109.0 109.5 --------- --------- 4,429.6 4,645.6 --------- --------- $12,595.5 $12,577.4 ========= =========
See notes to consolidated financial statements. 3 Consolidated Statements of Cash Flows ELI LILLY AND COMPANY AND SUBSIDIARIES (Dollars in millions)
Year Ended December 31 1998 1997 1996 - -------------------------------------------------------------------------------------------------------------------------------- Cash Flows From Operating Activities Net income (loss)................................................... $ 2,097.9 $ (385.1) $ 1,523.5 Adjustments To Reconcile Net Income (Loss) to Cash Flows From Operating Activities Depreciation and amortization..................................... 490.4 509.8 543.5 Change in deferred taxes.......................................... 25.4 (293.0) 207.3 Gain on sale of DowElanco, net of tax............................. - (303.5) - Asset impairment, net of tax...................................... - 2,429.6 - Other noncash income--net......................................... (93.0) (37.8) (97.8) --------- --------- --------- 2,520.7 1,920.0 2,176.5 Changes in operating assets and liabilities: Receivables--(increase) decrease............................... (403.6) (4.7) 104.4 Inventories--(increase)........................................ (55.6) (65.8) (42.2) Other assets--(increase)....................................... (81.1) (22.2) (51.7) Accounts payable and other liabilities--increase (decrease)............................. 649.4 573.1 (195.6) --------- --------- --------- 109.1 480.4 (185.1) --------- --------- --------- Net Cash From Operating Activities.................................. 2,629.8 2,400.4 1,991.4 Cash Flows From Investing Activities Acquisitions........................................................ - - (97.1) Additions to property and equipment................................. (419.9) (366.3) (443.9) Disposals of property and equipment................................. 30.6 11.5 11.2 Additions to other assets........................................... (120.1) (34.2) (40.8) Reductions of investments........................................... 273.1 365.7 396.9 Additions to investments............................................ (57.6) (388.5) (294.3) Proceeds from sale of DowElanco..................................... - 1,221.5 - --------- --------- --------- Net Cash From (Used for) Investing Activities....................................................... (293.9) 809.7 (468.0) Cash Flows From Financing Activities Dividends paid...................................................... (877.7) (818.0) (753.2) Purchases of common stock and other capital transactions............................................. (1,999.8) (351.3) (314.5) Issuances under stock plans......................................... 414.0 205.4 218.4 Issuance (redemption) of subsidiary stock........................... (172.8) 160.0 - Decrease in short-term borrowings................................... (170.0) (1,146.0) (801.4) Additions to long-term debt......................................... 23.8 2.8 - Reductions of long-term debt........................................ (30.2) (7.5) (10.4) --------- --------- --------- Net Cash Used for Financing Activities.............................. (2,812.7) (1,954.6) (1,661.1) Effect of exchange rate changes on cash............................. 25.0 (121.7) (48.1) --------- --------- --------- Net increase (decrease) in cash and cash equivalents................................................. (451.8) 1,133.8 (185.8) Cash and cash equivalents at beginning of year.......................................................... 1,947.5 813.7 999.5 --------- --------- --------- Cash and cash equivalents at end of year............................ $ 1,495.7 $ 1,947.5 $ 813.7 ========= ========= =========
See notes to consolidated financial statements. 4 Consolidated Statements of Comprehensive Income ELI LILLY AND COMPANY AND SUBSIDIARIES (Dollars in millions)
Year Ended December 31 1998 1997 1996 - -------------------------------------------------------------------------------------------------------------------------- Net income (loss).............................................. $2,097.9 $(385.1) $1,523.5 Other comprehensive income (loss): Foreign currency translation adjustments................................................ 69.2 (209.3) (57.4) Net unrealized losses on securities (Note 14)....................................... (2.6) (13.4) (56.9) Minimum pension liability adjustment......................... (30.8) (16.8) 1.0 -------- ------- -------- Other comprehensive income (loss), before income taxes................................................. 35.8 (239.5) (113.3) Provision for income taxes related to other comprehensive income items............................. 15.6 5.4 18.2 -------- ------- -------- Other comprehensive income (loss).............................. 51.4 (234.1) (95.1) -------- ------- -------- Comprehensive income (loss).................................... $2,149.3 $(619.2) $1,428.4 ======== ======= ========
See notes to consolidated financial statements. 5 Segment Information ELI LILLY AND COMPANY AND SUBSIDIARIES (Dollars in millions) The company operates in one significant business segment - pharmaceutical products. Operations of the animal health business are not material and are included with pharmaceutical products for purposes of segment reporting. Year Ended December 31 1998 1997 1996 - ----------------------------------------------------------------------------- Net sales - to unaffiliated customers Neurosciences............................. $4,487.8 $3,515.3 $2,665.8 Endocrinology............................. 1,482.5 1,381.8 1,286.6 Anti-infectives........................... 1,160.9 1,272.5 1,465.6 Animal health............................. 614.4 589.8 547.3 Cardiovascular............................ 536.9 421.0 325.4 Gastrointestinal.......................... 418.0 525.4 532.2 Oncology.................................. 339.2 210.6 104.1 Other pharmaceutical...................... 197.1 71.3 71.3 -------- -------- -------- Net sales....................................... $9,236.8 $7,987.7 $6,998.3 ======== ======== ======== Geographic Information Net sales - to unaffiliated customers1: United States............................... $5,836.2 $4,881.8 $3,917.3 Western Europe.............................. 1,692.3 1,462.9 1,455.2 Other foreign countries..................... 1,708.3 1,643.0 1,625.8 -------- -------- -------- $9,236.8 $7,987.7 $6,998.3 ======== ======== ======== Long-lived assets: United States............................... $3,421.9 $3,333.4 $3,595.1 Western Europe.............................. 675.4 632.2 663.4 Other foreign countries..................... 654.4 663.9 685.6 -------- -------- -------- $4,751.7 $4,629.5 $4,944.1 ======== ======== ======== /1/Net sales are attributed to the countries based on the location of the subsidiary making the sale. The largest category of products is the neurosciences group, which includes Prozac, Zyprexa, Darvon and Permax. Endocrinology products consist primarily of Humulin, Humatrope, Humalog and Iletin. Anti-infectives include primarily Ceclor, Keflex, Lorabid, Nebcin, Tazidime and Vancocin. Cardiovascular products consist primarily of ReoPro and Dobutrex. The gastrointestinal group is entirely composed of Axid. Oncology products consist primarily of Gemzar. Animal health products include Tylan; Micotil; Surmax; Rumensin, a nonhormonal cattle feed additive; anticoccidial agents for use in broilers and layer replacements, the largest of which is Coban; and other products for livestock and poultry. The other pharmaceutical product group includes Evista and other miscellaneous pharmaceutical products and services. Most of the pharmaceutical products are distributed through wholesalers that serve physicians and other health care professionals, pharmacies and hospitals. In 1998, the company's four largest wholesalers each accounted for between 10 percent and 17 percent of consolidated net sales. Animal health products are sold to wholesale distributors, retailers, manufacturers and producers. Total assets on the consolidated balance sheet include amounts from the discontinued operations of PCS (see Note 3). Total assets from continuing operations for 1998, 1997 and 1996 were $10.6 billion, $10.6 billion and $9.9 billion, respectively. Long-lived assets disclosed above consist of property and equipment, goodwill and certain sundry assets of the continuing operations. The company is exposed to the risk of changes in social, political and economic conditions inherent in foreign operations, and the company's results of operations and the value of its foreign assets are affected by fluctuations in foreign currency exchange rates. 6 Selected Quarterly Data (unaudited) ELI LILLY AND COMPANY AND SUBSIDIARIES (Dollars in millions, except per-share data)
1998/1/ Fourth Third Second First/2/ - ----------------------------------------------------------------------------------------- Net sales................................. $2,635.4 $2,359.4 $2,155.0 $2,087.0 Cost of sales............................. 583.5 495.7 478.6 457.3 Operating expenses........................ 1,329.2 1,107.5 1,054.1 906.4 Acquired in-process technology............ - 127.5 - - Other (income)/ expense-net............... 7.4 29.6 (25.0) 20.0 Income from continuing operations before income taxes and extraordinary item...................... 715.3 599.1 647.3 703.3 Income (loss) from: Continuing operations before extraordinary item..................... 561.6 512.2 490.9 531.6 Discontinued operations................. 5.7 6.0 0.4 (3.3) Net income................................ 567.3 518.2 491.3 521.1 Earnings per share - basic: Continuing operations before extraordinary item..................... .51 .47 .45 .48 Discontinued operations................. .01 - - - Net income.............................. .52 .47 .45 .47 Earnings per share - diluted: Continuing operations before extraordinary item..................... .50 .46 .44 .47 Discontinued operations................. .01 - - - Net income.............................. .51 .46 .44 .46 Dividends paid per share.................. .20 .20 .20 .20 Common stock prices: High................................... 91.31 81.63 73.75 72.38 Low.................................... 68.00 62.56 57.88 57.69 1997/1/................................... Fourth Third Second First - ----------------------------------------------------------------------------------------- Net sales................................. $2,258.0 $2,029.0 $1,859.6 $1,841.1 Cost of sales............................. 561.7 483.0 446.1 455.2 Operating expenses........................ 1,060.5 908.3 876.6 757.9 Asset impairment.......................... - - 97.8 - Gain on sale of DowElanco................. - 13.6 618.2 - Other (income)/expense - net.............. 18.0 31.6 (15.0) 36.7 Income from continuing operations before income taxes..................... 617.8 619.7 1,072.3 591.3 Income (loss) from: Continuing operations................... 465.1 464.1 636.0 450.7 Discontinued operations................. (7.6) (7.2) (2,368.2) (18.0) Net income (loss)......................... 457.5 456.9 (1,732.2) 432.7 Earnings (loss) per share - basic: Continuing operations................... .42 .42 .58 .41 Discontinued operations................. (.01) (.01) (2.15) (.02) Net income.............................. .41 .41 (1.57) .39 Earnings (loss) per share - diluted: Continuing operations................... .41 .41 .56 .40 Discontinued operations................. (.01) (.01) (2.10) (.02) Net income.............................. .40 .40 (1.54) .38 Dividends paid per share.................. .20 .18 .18 .18 Common stock prices: High................................... 70.44 61.75 55.75 47.50 Low.................................... 60.00 50.41 38.69 35.56
7 /1/ Amounts for net sales, cost of sales, operating expenses and other income/expense for the first three quarters of 1998 and all 1997 differ from previously reported amounts since the results of the health-care-management business have been reflected as discontinued operations (see Note 3). This restatement also caused a change in 1997 earnings per share. /2/ Reflects the impact of an extraordinary item (see Note 6). The company's common stock is listed on the New York, London, Tokyo and other stock exchanges. 8 Selected Financial Data (unaudited) ELI LILLY AND COMPANY AND SUBSIDIARIES (Dollars in millions, except per-share data)
1998 1997 1996 1995 1994 --------- -------- ---------- ---------- ---------- Operations/1/ Net sales...................... $9,236.8 $7,987.7 $6,998.3 $6,508.8 $5,686.5 Research and development....... 1,738.9 1,370.2 1,189.5 1,042.3 838.7 Other costs and expenses....... 4,832.9 4,348.2 3,677.5 3,599.9 3,154.5 Gain on sale of DowElanco...... - (631.8) - - - Income from continuing operations before taxes and extraordinary item........ 2,665.0 2,901.1 2,131.3 1,866.6 1,693.3 Income taxes................... 568.7 885.2 505.6 457.6 511.3 Income (loss)from: Continuing operations before extraordinary item......................... 2,096.3 2,015.9 1,625.7 1,409.0 1,182.0 Discontinued operations....... 8.8 (2,401.0) (102.2) 881.9 104.1 Net income (loss).............. 2,097.9/3/ (385.1) 1,523.5 2,290.9 1,286.1 Income from continuing operations before extraordinary item as a percent of sales............ 22.7% 25.2% 23.2% 21.6% 20.8% Per-share data - diluted: Income (loss) from: Continuing operations before extraordinary item........................ $1.87 $1.78 $1.45 $1.22 $1.01 Discontinued operations...... .01 (2.12) (.09) .77 .09 Net income (loss)............ 1.87/3/ (.34) 1.36 1.99 1.10 Dividends declared............. .83 .76 .694 .665 .63 Weighted-average number of shares outstanding - diluted (thousands)........... 1,121,486 1,130,579 1,117,110 1,152,016 1,170,916 ========= ========= ========= ========= ========== Financial Position Current assets................. $5,406.8 $5,320.7 $3,891.3 $4,138.6 $3,962.3 Current liabilities............ 4,607.2 4,191.6 4,222.2 4,967.0 5,669.5 Property and equipment-net..... 4,096.3 4,101.7 4,307.0 4,239.3 4,411.5 Total assets................... 12,595.5 12,577.4 14,307.2 14,412.5 14,507.4 Long-term debt................. 2,185.5 2,326.1 2,516.5 2,592.9 2,125.8 Shareholders' equity........... 4,429.6 4,645.6 6,100.1 5,432.6 5,355.6 ========= ========= ========= ========= ========== Supplementary Data/2/ Return on shareholders' equity........................ 46.2% 37.5% 28.2% 26.1% 23.8% Return on assets............... 17.0% 15.4% 11.4% 9.6% 10.8% Capital expenditures........... $419.9 $366.3 $443.9 $551.3 $576.5 Depreciation and amortization.................. 490.4 509.8 543.5 553.7 432.2 Effective tax rate............. 21.3% 30.5%/4/ 23.7% 24.5% 30.2% Number of employees........... 29,800 28,900 27,400 26,800 24,900 Number of shareholders of record....................... 62,300 58,200 54,500 52,600 55,900 ========= ========= ========= ========= ==========
/1/ Amounts for net sales, research and development, other costs and expenses, and income taxes for 1997, 1996, 1995 and 1994 differ from previously reported amounts since the results of the health-care-management business have been reflected as discontinued operations (see Note 3). This restatement also caused a change in 1997 earnings per share and weighted-average number of shares outstanding. /2/ All supplementary financial data have been computed using income from continuing operations except for capital expenditures and depreciation and amortization, which include amounts from discontinued operations. The number of employees reflects continuing operations, including controlled joint ventures. /3/ Reflects the impact of an extraordinary item (see Note 6). /4/ Excluding the impacts of the unusual transactions reflected in 1997, the effective tax rate would have been 24.1 percent. 9 Notes to Consolidated Financial Statements ELI LILLY AND COMPANY AND SUBSIDIARIES (Dollars in millions, except per-share data) Note 1: Summary of Significant Accounting Policies Basis of presentation: The accounts of all wholly owned and majority-owned subsidiaries are included in the consolidated financial statements. All intercompany balances and transactions have been eliminated. Certain 1997 and 1996 amounts, as previously reported, have been reclassified to conform to the 1998 presentation of discontinued operations (see Note 3). The preparation of financial statements in conformity with generally accepted accounting principles requires management to make estimates and assumptions that affect the reported amounts of assets, liabilities, revenues, expenses and related disclosures at the date of the financial statements and during the reporting period. Actual results could differ from those estimates. All per-share amounts, unless otherwise noted in the footnotes, are presented on a diluted basis, that is, based on the weighted-average number of outstanding common shares and the effect of all potentially dilutive common shares (primarily unexercised stock options). Cash equivalents: The company considers all highly liquid investments, generally with a maturity of three months or less, to be cash equivalents. The cost of these investments approximates fair value. Inventories: The company states all its inventories at the lower of cost or market. The company uses the last-in, first-out (LIFO) method for substantially all its inventories located in the continental United States, or approximately 50 percent of its total inventories. Other inventories are valued by the first- in, first-out (FIFO) method. Inventories at December 31 consisted of the following: 1998 1997 ------- ------- Finished products.................. $325.1 $262.0 Work in process.................... 435.8 459.4 Raw materials and supplies......... 236.3 191.0 ------ ------ 997.2 912.4 Increase (decrease) to LIFO cost... 2.7 (11.7) ------ ------ $999.9 $900.7 ====== ====== Investments: All short-term debt securities are classified as held-to-maturity because the company has the positive intent and ability to hold the securities to maturity. Held-to-maturity securities are stated at amortized cost, adjusted for amortization of premiums and accretion of discounts to maturity. Substantially all long-term debt and marketable equity securities are classified as available-for-sale. Available-for-sale securities are carried at fair value, with the unrealized gains and losses, net of tax, reported in other comprehensive income. The company owns no investments that are considered to be trading securities. Derivative financial instruments: The company's derivative activities, all of which are for purposes other than trading, are initiated within the guidelines of documented corporate risk-management policies and do not create additional risk because gains and losses on derivative contracts offset losses and gains on the assets, liabilities and transactions being hedged. As derivative contracts are initiated, the company designates the instruments individually as hedges of underlying financial instruments or anticipated transactions (i.e., underlying exposures). Management reviews the correlation and effectiveness of its derivatives on a periodic basis. Derivative contracts that do not qualify for deferral hedge accounting are marked to market. For terminations of derivatives receiving deferral accounting, gains and losses are deferred when the related underlying exposures remain outstanding 10 and are included in the measurement of the related transaction or balance. In addition, upon termination of the underlying exposures, the derivative is marked to market and the resulting gain or loss is included with the gain or loss on the related transaction. The company may redesignate the remaining derivative instruments as hedges of other underlying exposures. The company enters into foreign currency forward and option contracts to reduce the effect of fluctuating currency exchange rates (principally European currencies and the Japanese yen). Generally, foreign currency derivatives used for hedging are put in place using the same or like currencies and duration as the underlying exposures. Forward contracts are principally used to manage exposures arising from affiliate foreign currency balances. These contracts are marked to market with gains and losses recognized currently in income to offset the respective losses and gains recognized on the underlying exposures. The company also enters into purchased option contracts to hedge anticipated foreign currency transactions, primarily intercompany inventory activities expected to occur within the next year, and foreign currency forward contracts and currency swaps to hedge firm commitments. The contracts are designated and effective as hedges of those future transactions. Gains and losses on these contracts that qualify as hedges are deferred and recognized as an adjustment of the subsequent transaction when it occurs. Forward and option contracts generally have maturities not exceeding 12 months. The company may enter into interest rate swaps to manage interest rate exposures. The company designates the interest rate swaps as hedges of the underlying debt. Interest expense on the debt is adjusted to include the payments made or received under the swap agreements. Intangible assets: Intangible assets arising from acquisitions and research alliances are amortized over their estimated useful lives, ranging from five to 25 years, using the straight-line method. Impairments are recognized in operating results if impairment indicators are present and the expected future operating cash flows of the related assets are less than their carrying amounts. Property and equipment: Property and equipment is stated on the basis of cost. Provisions for depreciation of buildings and equipment are computed generally by the straight-line method at rates based on their estimated useful lives. At December 31, property and equipment consisted of the following:
1998 1997 -------- -------- Land........................................... $ 141.1 $ 130.6 Buildings...................................... 2,178.5 2,057.1 Equipment...................................... 4,556.6 4,373.8 Construction in progress....................... 398.3 473.4 -------- -------- 7,274.5 7,034.9 Less allowances for depreciation............... 3,178.2 2,933.2 -------- -------- $4,096.3 $4,101.7 ======== ========
Depreciation expense related to continuing operations for 1998, 1997 and 1996 was $393.4 million, $382.3 million and $379.4 million, respectively. Approximately $17.0 million, $20.4 million and $35.8 million of interest costs were capitalized as part of property and equipment in 1998, 1997 and 1996, respectively. Total rental expense for all leases related to continuing operations, including contingent rentals (not material), amounted to approximately $134.8 million for 1998, $111.8 million for 1997 and $107.0 million for 1996. Capital leases included in property and equipment in the consolidated balance sheets and future minimum rental commitments are not material. However, the company entered into capital lease obligations aggregating $13.3 million in 1998 and $8.8 million in 1997. Revenue recognition: Revenue from sales of products is recognized at the time products are shipped to the customer. Income taxes: Deferred taxes are recognized for the future tax effects of temporary differences between financial and income tax reporting based on 11 enacted tax laws and rates. Federal income taxes are provided on the portion of the income of foreign subsidiaries that is expected to be remitted to the United States and be taxable. Earnings (loss) per share: Basic earnings (loss) per share are calculated based on the weighted-average number of outstanding common shares and incremental shares. Diluted earnings (loss) per share are calculated based on the weighted- average number of outstanding common shares plus the effect of dilutive stock options and other incremental shares. Note 2: Implementation of New Financial Accounting Pronouncements Accounting Changes Effective January 1, 1998, the company adopted Statement of Financial Accounting Standards (SFAS) No. 130, "Reporting Comprehensive Income." Under provisions of this statement, the company has included a financial statement presentation of comprehensive income to conform to these new requirements. Statement 130 requires unrealized gains or losses on the company's available-for-sale securities, minimum pension liability adjustments and foreign currency translation adjustments, which, prior to adoption of the statement, were reported separately in shareholders' equity, to be included in other comprehensive income. As a consequence of this change, certain balance sheet reclassifications were necessary for previously reported amounts to achieve the required presentation of comprehensive income. See Note 14. Effective December 31, 1998, the company adopted SFAS No. 131, "Disclosures about Segments of an Enterprise and Related Information." Statement 131 requires public business enterprises to report information about operating segments in annual financial statements and requires that those enterprises report selected information about operating segments in interim financial reports. Statement 131 also establishes standards for related disclosures about products and services, geographic areas and major customers. See the segment information. Effective January 1, 1998, the company adopted SFAS No. 132, "Employers' Disclosures about Pensions and Other Postretirement Benefits." Statement 132 revises the disclosure requirements for employers' pensions and other retiree benefits. See Note 12. In June 1998, SFAS No. 133, "Accounting for Derivative Instruments and Hedging Activities," was issued. Statement 133 is required to be adopted in years beginning after June 15, 1999. The statement permits early adoption as of the beginning of any fiscal quarter after its issuance. The statement will require the company to recognize all derivatives on the balance sheet at fair value. Derivatives that are not hedges must be adjusted to fair value through income. If the derivative is a hedge, depending on the nature of the hedge, changes in the fair value of derivatives will either be offset against the change in fair value of the hedged assets, liabilities or firm commitments through earnings or recognized in other comprehensive income until the hedged item is recognized in earnings. Hedge ineffectiveness, the amount by which the change in the value of a hedge does not exactly offset the change in the value of the hedged item, will be immediately recognized in earnings. The company has not yet determined what the effect of Statement 133 will be on the earnings and financial position of the company or when the statement will be adopted. Effective January 1, 1998, the company adopted the American Institute of Certified Public Accountants (AICPA) Statement of Position (SOP) 98-1, "Accounting for the Costs of Computer Software Developed or Obtained for Internal Use." The SOP requires capitalization of certain costs incurred in the development of internal-use software, including external direct material and service costs, employee payroll and payroll-related costs, and capitalized interest. Prior to adoption of SOP 98-1, the company expensed certain of these costs as incurred. The effect of this change in accounting principle on consolidated earnings during the current period is immaterial. 12 In April 1998, the AICPA issued SOP 98-5, "Reporting the Costs of Start-up Activities." The SOP is effective beginning January 1, 1999, and requires that start-up costs capitalized prior to January 1, 1999, be written off and any future start-up costs be expensed as incurred. The unamortized balance of start-up costs will be written off as of January 1, 1999. The company estimates the impact of adopting this SOP will not result in a material reduction of 1999 earnings. Note 3: Discontinued Operations and Asset Impairment In November 1998, the company signed a definitive agreement for Rite Aid Corporation to acquire PCS, the company's health-care-management subsidiary for $1.6 billion in cash. The transaction closed on January 22, 1999, and will generate a gain of approximately $165 million to $185 million ($.15 to $.17 per share) in the first quarter of 1999. There will not be a significant tax effect on the gain. Because of the planned disposition of PCS, the results of operations of PCS have been classified as discontinued operations in the consolidated statements of income and prior periods have been restated. Selected income statement information for PCS follows:
1998 1997 1996 -------- ---------- -------- Revenues........................................ $814.5 $ 529.9 $ 348.3 Income tax expense.............................. 32.2 10.1 2.2 Income (loss) from discontinued operations.................................... 8.8 (2,401.0) (102.2)
In the second quarter of 1997, concurrent with PCS' annual planning process, the company determined that PCS' estimated future undiscounted cash flows were below the carrying value of PCS' long-lived assets. Accordingly, during the second quarter of 1997, the company adjusted the carrying value of PCS' long-lived assets, primarily goodwill, to their estimated fair value of approximately $1.5 billion, resulting in a noncash impairment loss of approximately $2.3 billion ($2.07 per share), which is included in discontinued operations. The estimated fair value was based on anticipated future cash flows discounted at a rate commensurate with the risk involved. The consolidated balance sheet and consolidated statements of cash flows include PCS. Selected balances, excluding intercompany amounts, as of December 31 were as follows:
1998 1997 -------- -------- Current assets.................................... $ 528.7 $ 408.9 Goodwill.......................................... 1,397.4 1,436.3 Total assets...................................... 2,026.5 1,945.7 Current liabilities............................... 886.3 714.7
An asset impairment charge related to continuing operations was also identified in the second quarter of 1997, concurrent with the annual planning process. The primary component of the $97.8 million ($.09 per share) noncash asset impairment charge was an adjustment to the carrying value of certain long-lived assets of a small portion of the company's health-care-management business that was not sold. Similar to the impairment of PCS' long-lived assets discussed above, the company determined that the estimated future undiscounted cash flows were below the carrying value of the related long-lived assets. Accordingly, the carrying value was adjusted to estimated fair value based on anticipated future cash flows, discounted at a rate commensurate with the risk involved. This business is now part of a joint venture, the results of which are immaterial to the consolidated financial statements. Note 4: Collaboration and Other Divestiture During 1998, the company announced a collaboration with ICOS Corporation to jointly develop and globally commercialize a phosphodiesterase type 5 (PDE5) inhibitor as an oral therapeutic agent for the treatment of both male and female sexual dysfunction. The compound is in the development phase (Phase II clinical trials) and no alternative future uses have been identified. As with many Phase 13 II compounds, launch of the product, if successful, would not be expected in the near term. Accordingly, under current accounting rules, the company's payments to acquire rights to this compound were required to be charged as a one-time expense of $127.5 million, which reduced earnings per share by approximately $.07 net of tax. On June 30, 1997, The Dow Chemical Company acquired the company's 40 percent interest in the DowElanco joint venture. The cash purchase price was $1.2 billion, resulting in a gain of $631.8 million ($303.5 million after-tax, or $.27 per share). Note 5: Financial Instruments Risk-Management Instruments and Off-Balance-Sheet Risk In the normal course of business, operations of the company are exposed to fluctuations in currency values and interest rates. These fluctuations can vary the costs of financing, investing and operating. The company addresses a portion of these risks through a controlled program of risk management that includes the use of derivative financial instruments. The notional amounts of derivatives summarized in the following paragraphs do not represent amounts exchanged by the parties and thus are not a measure of the exposure of the company through its use of derivatives. The company is exposed to credit-related losses in the event of nonperformance by counterparties to financial instruments, but it does not expect any counterparties to fail to meet their obligations given their high credit ratings. At December 31, the stated, or notional, amounts of the company's outstanding derivative financial instruments were as follows:
1998 1997 -------- -------- Forward exchange contracts....................... $448.3 $593.9 Foreign currency options - purchased............. 606.0 504.5 Interest rate swaps.............................. - 30.0
Financial instruments that potentially subject the company to credit risk consist principally of trade receivables and interest-bearing investments. Wholesale distributors of life-sciences products and managed care organizations account for a substantial portion of trade receivables; collateral is generally not required. The risk associated with this concentration is limited due to the company's ongoing credit review procedures. The company places substantially all its interest-bearing investments with major financial institutions, in U.S. Government securities or with top-rated corporate issuers. In accordance with documented corporate policies, the company limits the amount of credit exposure to any one financial institution. Fair Value of Financial Instruments A summary of the company's outstanding financial instruments at December 31 follows. As summarized, "cost" relates to investments while "carrying amount" relates to long-term debt.
1998 1997 --------------------------------------------------------------- Cost/Carrying Fair Cost/Carrying Fair Amount Value Amount Value ------ ----- ------ ----- Short-term investments: Debt securities............................ $ 101.4 $ 102.7 $ 77.1 $ 76.9 Noncurrent investments: Marketable equity.......................... 66.5 70.4 77.7 86.0 Debt securities............................ 38.6 38.6 93.0 94.3 Nonmarketable equity....................... 26.1 26.1 33.7 33.7 Long-term debt, including current portion............................. 2,337.7 2,629.7 2,524.4 2,684.7
14 The company determines fair values based on quoted market values where available or discounted cash flow analyses (principally long-term debt). The fair values of nonmarketable equity securities, which represent either equity investments in start-up technology companies or partnerships that invest in start-up technology companies, are estimated based on the fair value information provided by these ventures. The fair value and carrying amount of risk-management instruments were not material at December 31, 1998 or 1997. At December 31, 1998 and 1997, the gross unrealized holding gains on available- for-sale securities were $22.7 million and $20.0 million, respectively, and the gross unrealized holding losses were $ 20.6 million and $15.3 million, respectively. Substantially all these gains and losses are associated with the marketable equity securities. The proceeds from sales of available-for-sale securities totaled $36.3 million, $39.7 million and $102.1 million in 1998, 1997 and 1996, respectively. Realized gains on sales of available-for-sale securities were $20.6 and $6.6 million in 1998 and 1997, respectively. Realized losses on sales of available-for-sale securities were $2.5 and $25.3 million in 1998 and 1997, respectively. Realized gains and losses were not significant in 1996. The net adjustment to unrealized gains and losses on available-for-sale securities reduced shareholders' equity by $1.7 million and $7.7 million in 1998 and 1997, respectively. The company is a limited partner in certain affordable housing investments that generate benefits in the form of tax credits. The determination of fair value of these investments is not practicable. The carrying value of such investments was $68.9 million and $251.6 million as of December 31, 1998 and 1997, respectively. The reduction in carrying value was a result of sales of these investments during 1998. Note 6: Borrowings Long-term debt at December 31 consisted of the following:
1998 1997 -------- -------- 6.57 to 7.13 percent notes (due 2016-2036)............. $1,000.0 $1,000.0 6.25 to 8.38 percent notes (due 1999-2006)............. 750.0 750.0 8.13 to 8.38 percent eurodollar bonds (due 2000-2005)..................................... 350.0 500.0 7.10 percent medium-term notes (due 1999).............. 36.5 36.5 6.55 percent ESOP debentures (due 2017)................ 99.6 - 8.18 percent ESOP debentures........................... - 100.6 Other, including capitalized leases.................... 101.6 137.3 -------- -------- 2,337.7 2,524.4 Less current portion................................... 152.2 198.3 -------- -------- $2,185.5 $2,326.1 ======== ========
The 6.55 percent Employee Stock Ownership Plan (ESOP) debentures are obligations of the ESOP but are shown on the consolidated balance sheet because they are guaranteed by the company. The principal and interest on the debt will be funded by contributions from the company and by dividends received on certain shares held by the ESOP. Because of the amortizing feature of the ESOP debt, bondholders will receive both interest and principal payments each quarter. The 6.55 percent ESOP debentures replaced the 8.18 percent ESOP debentures pursuant to a refinancing in March 1998. An extraordinary charge of $12.0 million, net of a $4.8 million income tax benefit, was recorded as a result of this refinancing. The aggregate amounts of maturities on long-term debt for the next five years are as follows: 1999, $152.2 million; 2000, $213.7 million; 2001, $162.9 million; 2002, $12.0 million; and 2003, $211.0 million. At December 31, 1998 and 1997, short-term borrowings included $29.2 million and $29.3 million, respectively, of notes payable to banks. At December 31, 1998, unused committed lines of credit totaled approximately $2.2 billion. Compensating balances and commitment fees are not material, and there are no 15 conditions that are probable of occurring under which the lines may be withdrawn. Cash payments of interest on borrowings totaled $188.2 million, $243.9 million and $292.9 million in 1998, 1997 and 1996, respectively. Note 7: Stock Plans Stock options are granted to employees at exercise prices equal to the fair market value of the company's stock at the dates of grant. Generally, options vest 100 percent three years from the grant date and have a term of 10 years. Performance awards are granted to officers and key employees and are payable in shares of the company's common stock. The number of performance award shares actually issued varies depending upon the achievement of certain earnings targets. In general, performance awards vest 100 percent at the end of the second fiscal year following the grant date. The company has elected to follow Accounting Principles Board Opinion (APB) No. 25, "Accounting for Stock Issued to Employees" and related interpretations in accounting for its stock options and performance awards. Under APB No. 25, because the exercise price of the company's employee stock options equals the market price of the underlying stock on the date of grant, no compensation expense is recognized. Total compensation expense for stock-based performance awards reflected in income on a pretax basis was $257.8 million, $242.1 million and $164.2 million in 1998, 1997 and 1996, respectively. However, SFAS No. 123, "Accounting for Stock-Based Compensation," requires presentation of pro forma information as if the company had accounted for its employee stock options and performance awards granted subsequent to December 31, 1994, under the fair value method of that statement. For purposes of pro forma disclosure, the estimated fair value of the options and performance awards at the date of the grant is amortized to expense over the vesting period. Under the fair value method, the company's net income (loss) and earnings (loss) per share would have been as follows: 1998 1997 1996 ---- ---- ---- Net income (loss)........................ $2,120.9 $(339.5) $1,508.3 Earnings (loss) per share - diluted...... 1.89 (.30) 1.35 Because SFAS No. 123 is applicable only to options and performance awards granted subsequent to December 31, 1994, and the options and performance awards have three-year and two-year vesting periods, respectively, the pro forma effect was not fully reflected until 1998. The weighted-average per-share fair value of the individual options and performance awards granted during 1998, 1997 and 1996 were as follows on the date of grant: 1998 1997 1996 ---- ---- ---- Employee stock options............ $16.64 $15.55 $ 8.25 Performance awards................ 88.88 69.63 36.50 The fair values of the options were determined using a Black-Scholes option- pricing model with the following assumptions: 1998 1997 1996 ---- ---- ---- Dividend yield................... 2.96% 3.14% 3.24% Volatility....................... 23.5% 21.5% 21.0% Risk-free interest rate.......... 4.29% 6.18% 6.36% Forfeiture rate.................. 0 0 0 Expected life.................... 7 years 7 years 7 years 16 Stock option activity during 1996-1998 is summarized below: Shares of Weighted-Average Common Stock Exercise Attributable Price of to Options Options ------------------------------------- Unexercised at January 1, 1996.......... 75,233,590 $16.51 Granted................................. 6,340,874 33.55 Exercised............................... (14,583,420) 12.94 Forfeited............................... (1,081,168) 20.93 ----------- Unexercised at December 31, 1996........ 65,909,876 18.86 Granted................................. 5,854,408 64.73 Exercised............................... (10,072,728) 13.88 Forfeited............................... (797,912) 22.30 ----------- Unexercised at December 31, 1997........ 60,893,644 24.05 Granted................................. 6,803,350 74.18 Exercised............................... (13,696,906) 16.88 Forfeited............................... (1,047,023) 24.29 ----------- Unexercised at December 31, 1998........ 52,953,065 32.35 =========== The following table summarizes information concerning outstanding and exercisable options at December 31, 1998 (shares in millions, contractual life in years): Options Outstanding Options Exercisable - -------- ------------------------------------- ----------------------- Weighted- Average Weighted- Weighted- Range of Remaining Average Average Exercise Number Contractual Exercise Number Exercise Prices Outstanding Life Price Exercisable Price - -------- ------------------------------------- -------------------------- $10 - $20 17.70 4.57 $13.90 17.70 $13.90 $20 - $30 16.90 6.37 $23.14 16.90 $23.14 $30 - $75 18.35 8.85 $58.63 1.22 $52.36 Shares exercisable at December 31, 1998, were 35.8 million (1997 - 29.6 million shares, 1996 - 30.6 million shares). As noted above, the number of shares ultimately issued pursuant to the performance award program is dependent upon the earnings achieved during the vesting period. Pursuant to this plan, 1,543,047 shares, 1,119,487 shares and 1,064,899 shares were issued in 1998, 1997 and 1996, respectively. At December 31, 1998, plan participants had the right to receive up to 7,719,450 additional shares (reduced to the extent necessary to satisfy payroll tax withholdings), contingent upon earnings achieved. At December 31, 1998, additional options, performance awards or restricted stock grants may be granted under the 1998 Lilly Stock Plan for not more than 45.8 million shares (1.3 million shares and 6.6 million shares in 1997 and 1996, respectively, under the 1994 Lilly Stock Plan). 17 Note 8: Shareholders' Equity Changes in certain components of shareholders' equity were as follows:
Additional Deferred Paid-in Retained Costs - Common Stock in Treasury Capital Earnings ESOP Shares Amount ----------------- ---------- --------- -------------------------- Balance at January 1, 1996..................... $ 418.3 $ 6,435.7 $(199.5) 18,149,494 $ 1,625.5 Net income............................ 1,523.5 Cash dividends declared per share: $.695............................... (762.9) Purchase for treasury................. 5,315,000 318.5 Issuance of stock under employee stock plans................ (368.4) (7,384,672) (648.0) ESOP transactions..................... 17.5 22.6 Other................................. 0.7 (499) (0.1) -------- --------- ------- ---------- --------- Balance at December 31, 1996................... 67.4 7,197.0 (176.9) 16,079,323 1,295.9 Net loss.............................. (385.1) Cash dividends declared per share: $.76......................... (840.9) Stock dividend declared............................ (346.5) Retirement of treasury shares..................... (1,134.5) (14,223,272) (1,143.4) Purchase for treasury............................ 3,400,000 355.3 Issuance of stock under employee stock plans............................... (99.7) (4,247,216) (397.4) ESOP transactions..................... 39.6 21.2 Other................................. (0.3) 0.3 (8,835) (0.9) Reclassification...................... 1,127.5 (1,127.5) -------- --------- ------- ---------- --------- Balance at December 31,1997.................... - 4,497.3 (155.7) 1,000,000 109.5 Net income............................ 2,097.9 Cash dividends declared per share: $.83................................ (908.9) Retirement of treasury shares.............................. (2,035.2) (29,009,799) (2,053.3) Purchase for treasury................. 28,349,900 2,005.8 Issuance of stock under employee stock plans................ 558.7 659,899 47.5 ESOP transactions..................... 23.6 8.8 Other................................. 5.4 (10.0) (4,508) (0.5) Reclassification...................... 1,447.5 (1,447.5) -------- --------- ------- ---------- --------- Balance at December 31, 1998................... $ - $ 4,228.8 $(146.9) 995,492 $ 109.0 ======== ========= ======= ========== =========
As shown above, the company has completed its previously announced $2 billion share repurchase, acquiring approximately 28.3 million shares in 1998. The company expects to repurchase shares costing approximately $1 billion in 1999. The company has an Employee Stock Ownership Plan (ESOP) as a funding vehicle for the existing employee savings plan. The ESOP used the proceeds of a loan from the company to purchase shares of common stock from the treasury. In 1991, the ESOP issued $200 million of third-party debt, repayment of which was guaranteed by the company (see Note 6). The proceeds were used to purchase shares of the company's common stock on the open market. Shares of common stock held by the ESOP will be allocated to participating employees annually through 2017 as part of the company's savings plan contribution. The fair value of shares allocated each period is recognized as compensation expense. 18 On October 15, 1997, the company effected a two-for-one stock split in the form of a 100 percent stock dividend payable to shareholders of record on September 24, 1997. The outstanding and weighted-average number of shares of common stock and per-share data in these financial statements have been adjusted to reflect the impact of the stock split for all periods presented. Treasury shares held by the company were not split. A new Shareholder Rights Plan was adopted by the company's board of directors to replace the existing plan, which expired on July 28, 1998. Under the terms of the new plan, all shareholders of record as of July 28, 1998, received for each common share owned a preferred stock purchase right entitling them to purchase from the company one one-thousandth of a share of Series B Junior Participating Preferred Stock (the "Preferred Stock") at a price of $325. The rights are not exercisable until after the "Distribution Date," which is generally defined as the 10th business day after the date of a public announcement that a person (the "Acquiring Person") has acquired ownership of 15 percent or more of the company's common stock. The company may redeem the rights for $.005 per right up to and including the Distribution Date. The rights will expire on July 28, 2008, unless redeemed earlier by the company. The plan provides that, if an Acquiring Person acquires 15 percent or more of the outstanding common stock of the company and the company's redemption right has expired, generally each holder of a right (other than the Acquiring Person) will have the right to purchase at the exercise price the number of shares of common stock of the company as have a value of two times the exercise price. Alternatively, if, in a transaction not approved by the board of directors, the company is acquired in a business combination transaction or sells 50 percent or more of its assets or earning power after a Distribution Date, generally each holder of a right (other than the Acquiring Person) will have the right to purchase at the exercise price the number of shares of common stock of the acquiring company as have a value of two times the exercise price. At any time after an Acquiring Person has acquired 15 percent or more but less than 50 percent of the company's outstanding common stock, the board of directors may exchange the rights (other than those owned by the Acquiring Person) for company common stock or Preferred Stock at an exchange ratio of one common share (or one one-thousandth of a share of Preferred Stock) per right. Note 9: Minority Interest in Subsidiary In November 1998, in connection with the sale of the company's PCS subsidiary (see Note 3), PCS repurchased its convertible Class B shares. The Class B shares were initially issued and sold to an institutional investor in October 1997 for $160 million. Prior to their repurchase, the Class B shares paid dividends on a quarterly basis at 25 basis points above the three-month LIBOR rate. 19 Note 10: Earnings per Share The following is a reconciliation of the numerators and denominators used in computing earnings per share from continuing operations before extraordinary item:
1998 1997 1996 -------------------------------------------------------- (Shares in thousands) Income from continuing operations before extraordinary item available to common shareholders: Income from continuing operations before extraordinary item.................................. $ 2,096.3 $ 2,015.9 $ 1,625.7 Preferred stock dividends.................................. (1.7) (2.6) (3.6) ---------- ---------- ---------- Income from continuing operations before extraordinary item available to common shareholders..................................... $ 2,094.6 $ 2,013.3 $ 1,622.1 ========== ========== ========== Basic earnings per share: Weighted-average number of common shares outstanding, including incremental shares........................................ 1,095,834 1,101,513 1,093,920 ========== ========== ========== Basic earnings per share from continuing operations before extraordinary item........................................ $ 1.91 $ 1.83 $ 1.48 ========== ========== ========== Diluted earnings per share: Weighted-average number of common shares outstanding........................................ 1,095,537 1,101,099 1,093,654 Stock options and other incremental 25,949 29,480 23,456 shares.................................................... ---------- ---------- ---------- Weighted-average number of common shares outstanding - diluted.............................. 1,121,486 1,130,579 1,117,110 ========== ========= ========= Diluted earnings per share from continuing operations before extraordinary item....................................... $ 1.87 $ 1.78 $ 1.45 ========== ========== ==========
20 Note 11: Income Taxes Following is the composition of income taxes attributable to continuing operations before extraordinary item:
1998 1997 1996 ---- ---- ---- Current: Federal................................................ $322.1 $ 766.1 $309.5 Foreign................................................ 238.9 392.3 143.1 State.................................................. (8.9) 51.5 6.2 ------ -------- ------ 552.1 1,209.9 458.8 Deferred: Federal................................................. (2.4) (284.5) 22.9 Foreign................................................. 9.4 9.6 7.8 State................................................... 9.6 (49.8) 16.1 ------ ------- ------ 16.6 (324.7) 46.8 ------ -------- ------ Income taxes............................................... $568.7 $ 885.2 $505.6 ====== ======== ======
Significant components of the company's deferred tax assets and liabilities as of December 31 are as follows:
1998 1997 ---- ---- Deferred tax assets: Tax credit carryforwards and carrybacks................................................... $ 589.9 $ 289.4 Other carryforwards............................................ 223.2 53.7 Capital loss carryforward...................................... 703.7 108.6 Inventory...................................................... 251.0 248.7 Compensation and benefits...................................... 183.1 173.1 Contingent liabilities......................................... 78.1 117.5 Other.......................................................... 244.6 263.4 --------- -------- 2,273.6 1,254.4 Valuation allowances........................................... (810.0) (110.2) --------- -------- Total deferred tax assets................................... 1,463.6 1,144.2 Deferred tax liabilities: Property and equipment......................................... (540.4) (555.9) Unremitted earnings............................................ (512.8) (152.0) Prepaid employee benefits...................................... (238.3) (229.6) Other.......................................................... (54.7) (61.3) --------- -------- Total deferred tax liabilities.............................. (1,346.2) (998.8) --------- -------- Deferred tax assets - net......................................... $ 117.4 $ 145.4 ========= ========
At December 31, 1998, the company had operating and capital loss carryforwards for income tax purposes of $270.3 million: $148.1 million will expire within five years and $85.7 million thereafter; $36.5 million of the carryforwards will never expire. The company also has tax credit carryforwards of $548.6 million available to reduce future income taxes: $443.6 million will expire within five years and $73.0 million thereafter; $32.0 million of the tax credit carryforwards will never expire. As discussed in Note 3, the company signed a definitive agreement to sell its PCS health-care-management subsidiary in November 1998, and the sale closed in January 1999. As a consequence of the agreement, the company recorded a deferred tax asset of $655.3 million for the tax capital loss that resulted from this transaction. This loss can be carried forward five years. A valuation allowance was established for this asset due to the uncertain realization of the benefit. Domestic and Puerto Rican companies contributed approximately 60 percent, 73 percent and 74 percent in 1998, 1997 and 1996, respectively, to consolidated income from continuing operations before income taxes and extraordinary item. Unremitted earnings of foreign subsidiaries that have been, or are intended to be, permanently reinvested for continued use in foreign operations and that, 21 if distributed, would result in taxes at approximately the U.S. statutory rate, aggregated $1.01 billion at December 31, 1998 ($115 million at December 31, 1997). Cash payments of income taxes totaled $273 million, $542 million and $289 million in 1998, 1997 and 1996, respectively. Following is a reconciliation of the effective income tax rate applicable to income from continuing operations:
1998 1997 1996 ---------------------------------------------------------- United States federal statutory tax.............................. 35.0% 35.0% 35.0% Add (deduct): International operations, including Puerto Rico................................................... (10.5) (1.3) (8.9) General business credits........................................ (2.4) (2.2) (1.6) Valuation allowance reversal.................................... (1.5) - - Sale of investments............................................. - (1.7) - Sundry.......................................................... 0.7 0.7 (0.8) ----- ---- ---- Effective income tax............................................. 21.3% 30.5% 23.7% ===== ==== ====
Excluding the impact of the gain on the sale of DowElanco and asset impairment, the effective income tax rate applicable to continuing operations for 1997 would have been 24.1 percent. 22 Note 12: Retirement Benefits The change in benefit obligation, change in plan assets, funded status and amounts recognized in the consolidated balance sheets at December 31 for the company's defined benefit pension and retiree health benefit plans were as follows:
Defined Benefit Retiree Health Pension Plans Benefits --------------------------------------------------------------------------- 1998 1997 1998 1997 ---- ---- ---- ---- Change in benefit obligation: Benefit obligation at beginning of year............................... $2,550.9 $2,303.5 $ 477.5 $ 412.1 Service cost..................................... 115.5 89.2 13.3 11.2 Interest cost.................................... 185.8 179.0 34.5 31.6 Actuarial loss................................... 229.8 176.8 139.2 60.7 Benefits paid.................................... (170.3) (165.8) (43.3) (37.6) Foreign currency exchange rate changes and other adjustments.................. (12.9) (31.8) 0.3 (0.5) -------- -------- ------- ------- Benefit obligation at end of year............................................ 2,898.8 2,550.9 621.5 477.5 Change in plan assets: Fair value of plan assets at beginning of year............................... 2,923.2 2,629.2 228.1 200.1 Actual return on plan assets..................... 286.4 407.7 33.8 30.1 Employer contribution............................ 28.1 65.7 33.9 35.5 Benefits paid.................................... (170.3) (165.8) (43.3) (37.6) Foreign currency exchange rate changes and other adjustments................... 2.2 (13.6) - - -------- -------- ------- ------- Fair value of plan assets at end of year..................................... 3,069.6 2,923.2 252.5 228.1 -------- -------- ------- ------- Funded status.................................... 170.8 372.3 (369.0) (249.4) Unrecognized net actuarial (gain) loss............................................ 202.7 (13.8) 254.9 134.2 Unrecognized prior service cost (benefit)....................................... 130.5 118.0 (0.6) (3.1) Unrecognized net obligation at January 1, 1986................................. 2.6 3.0 - - -------- -------- ------- ------- Net amount recognized............................ $ 506.6 $ 479.5 $(114.7) $(118.3) ======== ======== ======= ======= Amounts recognized in the consolidated balance sheet consisted of: Prepaid benefit cost........................... $ 612.3 $ 579.1 $ - $ - Accrued benefit liability...................... (192.3) (131.6) (114.7) (118.3) Intangible asset............................... 37.9 14.1 - - Accumulated other comprehensive income before income taxes.................... 48.7 17.9 - - -------- -------- ------- ------- Net amount recognized.......................... $ 506.6 $ 479.5 $(114.7) $(118.3) ======== ======== ======= =======
23
Defined Benefit Retiree Health Pension Plans Benefits ------------------------------------------------------------------ 1998 1997 1998 1997 ---- ---- ---- ---- (Percents) Weighted-average assumptions as of December 31: Discount rate................................... 6.9 7.5 7.0 7.5 Expected return on plan assets.................. 10.5 10.5 10.5 10.5 Rate of compensation increase................... 4.0-8.0 4.0-8.0 - -
Health-care-cost trend rates were assumed to increase at an annual rate of 6.5 percent in 1999 for participants under age 65, decreasing one-half percent per year to 5.0 percent in 2002 and thereafter. For participants over age 65, the rate was assumed to increase 5.0 percent in 1999 and thereafter. The discount rate decrease at December 31, 1998, increased the projected benefit obligation for the defined benefit plans and the retiree health benefits plans by approximately $227.4 million and $61.2 million, respectively. The projected benefit obligation, accumulated benefit obligation and fair value of the plan assets for the defined benefit pension plans with projected benefit obligations in excess of plan assets were $586.6 million, $502.3 million and $349.7 million, respectively, as of December 31, 1998, and $478.0 million, $386.9 million and $318.3 million, respectively, as of December 31, 1997. Net pension and retiree health benefit expense included the following components related to continuing operations:
Defined Benefit Retiree Health Pension Plans Benefits -------------------------------------------------------- 1998 1997 1996 1998 1997 1996 ---- ---- ---- ---- ---- ---- Components of net periodic benefit cost: Service cost........................... $ 112.9 $ 86.3 $ 81.9 $ 12.8 $ 10.9 $ 11.4 Interest cost.......................... 184.2 178.0 166.3 34.3 31.5 28.7 Expected return on plan assets............................... (277.1) (252.2) (235.1) (23.0) (21.1) (19.0) Amortization of prior service cost (benefit)............... 9.7 9.2 8.8 (3.3) (7.9) (8.6) Recognized actuarial loss................................. 3.4 0.3 1.0 7.3 4.0 3.9 ------- ------- ------- ------ ------ ------ Net periodic benefit cost................................. $ 33.1 $ 21.6 $ 22.9 $ 28.1 $ 17.4 $ 16.4 ======= ======= ======= ====== ====== ======
The assumed health-care-cost trend rates have a significant effect on the amounts reported. If these trend rates were to be increased by one percentage point each future year, the December 31, 1998, accumulated postretirement benefit obligation would increase by 10 percent and the aggregate of the service cost and interest cost components of 1998 annual expense would increase by 15 percent. A one-percentage-point decrease in these rates would decrease the December 31, 1998, accumulated postretirement benefit obligation by 9 percent and the aggregate of the 1998 service cost and interest cost by 13 percent. The company has defined contribution savings plans that cover its eligible employees worldwide. The purpose of these defined contribution plans is generally to provide additional financial security during retirement by providing employees with an incentive to make regular savings. Company contributions to the plan are based on employee contributions and the level of company match. Expenses under the plans related to continuing operations totaled $50.3 million, $43.5 million and $39.6 million for the years 1998, 1997 and 1996, respectively. The company provides certain other postemployment benefits, primarily related to disability benefits, and accrues for the related cost over the service lives of 24 the employees. Expenses associated with these benefit plans in 1998, 1997 and 1996 were not significant. Note 13: Contingencies Barr Laboratories, Inc. (Barr), and Geneva Pharmaceuticals, Inc. (Geneva), have each submitted an Abbreviated New Drug Application (ANDA) seeking FDA approval to market generic forms of Prozac before the expiration of the company's patents. The ANDAs assert that two U.S. patents held by Lilly covering Prozac are invalid and unenforceable. The company filed suit against Barr and Geneva in federal court in Indianapolis seeking a ruling that Barr's challenge to Lilly's patents is without merit. On January 12, 1999, the trial court granted summary judgment in favor of Lilly on two of the four claims raised by Barr and Geneva against Lilly's patents. The company expects that the decision will be appealed. On January 25, 1999, Barr and Geneva dismissed their other two claims in exchange for a $4 million payment, which Barr and Geneva will share with a third defendant. In late 1998, three other generic pharmaceutical companies, Zenith Goldline Pharmaceuticals, Teva Pharmaceuticals USA and Reddy-Cheminor, Inc., each filed ANDAs for generic forms of Prozac, asserting that the later of the two patents (expiring in December 2003) is invalid and unenforceable. Finally, in January 1999, Novex Pharma division of Apotex, Inc., filed an ANDA challenging both patents. Lilly has filed suits against the four companies in federal court in Indianapolis. The suits are in a very early stage. While the company believes that the claims of the six generic companies are without merit, there can be no assurance that the company will prevail. An unfavorable outcome of this litigation could have a material adverse effect on the company's consolidated financial position, liquidity and results of operations. The company has been named as a defendant in numerous product liability lawsuits involving primarily two products, diethylstilbestrol and Prozac. The company has accrued for its estimated exposure, including costs of litigation, with respect to all current product liability claims. In addition, the company has accrued for certain future anticipated product liability claims to the extent the company can formulate a reasonable estimate of their costs. The company's estimates of these expenses are based primarily on historical claims experience and data regarding product usage. The company expects the cash amounts related to the accruals to be paid out over the next several years. The majority of costs associated with defending and disposing of these suits are covered by insurance. The company's estimate of insurance recoverables is based on existing deductibles, coverage limits, and the existing and projected future level of insolvencies among its insurance carriers. Under the Comprehensive Environmental Response, Compensation, and Liability Act, commonly known as Superfund, the company has been designated as one of several potentially responsible parties with respect to certain sites. Under Superfund, each responsible party may be jointly and severally liable for the entire amount of the cleanup. The company also continues remediation of certain of its own sites. The company has accrued for estimated Superfund cleanup costs, remediation and certain other environmental matters, taking into account, as applicable, available information regarding site conditions, potential cleanup methods, estimated costs and the extent to which other parties can be expected to contribute to payment of those costs. The company has reached a settlement with its primary liability insurance carrier providing for coverage for certain environmental liabilities and has instituted litigation seeking coverage from certain excess carriers. The company continues to be a defendant, together with numerous other U.S. prescription drug manufacturers, in related suits brought under federal and state antitrust laws by many retail pharmacies and, in some cases, consumers. The company has now resolved the great majority of the retailer claims, and, subject in certain cases to court approval, has also settled the great majority of the consumer claims. The environmental liabilities and litigation accruals have been reflected in the company's consolidated balance sheet at the gross amount of approximately $300.7 million at December 31, 1998. Estimated insurance recoverables of approximately 25 $240.9 million at December 31, 1998, have been reflected as assets in the consolidated balance sheet. While it is not possible to predict or determine the outcome of the patent, product liability, antitrust, or other legal actions brought against the company or the ultimate cost of environmental matters, the company believes that, except as noted above, the costs associated with all such matters will not have a material adverse effect on its consolidated financial position or liquidity but could possibly be material to the consolidated results of operations in any one accounting period. Note 14: Other Comprehensive Income The accumulated balances related to each component of other comprehensive income were as follows:
Unrealized Minimum Accumulated Foreign Gains Pension Other Currency (Losses) on Liability Comprehensive Translation Securities Adjustment Income ------------------- ------------------- ------------------- ------------------- Beginning balance at January 1, 1998.................... $ (267.0) $ 3.2 $ (17.4) $ (281.2) Other comprehensive income (loss)...................... 69.2 (1.7) (16.1) 51.4 ------- ----- ------ ------- Balance at December 31, 1998......... $ (197.8) $ 1.5 $ (33.5) $ (229.8) ======= ===== ====== =======
The amounts above are net of income taxes. The income taxes related to other comprehensive income were not significant as income taxes were generally not provided for foreign currency translation. The unrealized gains (losses) on securities is net of a reclassification adjustment of $4.8 million, net of tax, in 1998 for realized gains and losses on sales of securities included in net income. Generally, the assets and liabilities of foreign operations are translated into U.S. dollars using the current exchange rate. For those operations, changes in exchange rates generally do not affect cash flows; therefore, resulting translation adjustments are made to shareholders' equity rather than to income. 26 Responsibility for Financial Statements Eli Lilly and Company and Subsidiaries The consolidated financial statements and related notes have been prepared by management, who are responsible for their integrity and objectivity. The statements have been prepared in accordance with generally accepted accounting principles and include amounts based on judgments and estimates by management. The other financial information in this annual report is consistent with that in the financial statements. The company maintains internal accounting control systems that are designed to provide reasonable assurance that assets are safeguarded, that transactions are executed in accordance with management's authorization and are properly recorded, and that accounting records are adequate for preparation of financial statements and other financial information. The design, monitoring and revision of internal accounting control systems involve, among other things, management's judgments with respect to the relative cost and expected benefits of specific control measures. A staff of internal auditors regularly monitors, on a worldwide basis, the adequacy and effectiveness of internal accounting controls. In addition to the system of internal accounting controls, the company maintains guidelines of company policy emphasizing proper overall business conduct, possible conflicts of interest, compliance with laws and confidentiality of proprietary information. The guidelines are reviewed on a periodic basis with employees worldwide. The financial statements have been audited by Ernst & Young LLP, independent auditors. Their responsibility is to examine the company's financial statements in accordance with generally accepted auditing standards and to express their opinion with respect to the fairness of presentation of the statements. The members of the audit committee of the board of directors, none of whom are employees of the company, recommend independent auditors for appointment by the board of directors, review the services performed by the independent auditors, and receive and review the reports submitted by them. The audit committee meets several times during the year with management, the internal auditors and the independent auditors to discuss audit activities, internal controls and financial reporting matters. The internal auditors and the independent auditors have full and free access to the committee. Sidney Taurel Chairman of the Board, President and Chief Executive Officer Charles E. Golden Executive Vice President and Chief Financial Officer January 30, 1999 27 Report of Independent Auditors Board of Directors and Shareholders Eli Lilly and Company We have audited the accompanying consolidated balance sheets of Eli Lilly and Company and subsidiaries as of December 31, 1998 and 1997, and the related consolidated statements of income, cash flows and comprehensive income for each of the three years in the period ended December 31, 1998. These financial statements are the responsibility of the company's management. Our responsibility is to express an opinion on these financial statements based on our audits. We conducted our audits in accordance with generally accepted auditing standards. Those standards require that we plan and perform the audit to obtain reasonable assurance about whether the financial statements are free of material misstatement. An audit includes examining, on a test basis, evidence supporting the amounts and disclosures in the financial statements. An audit also includes assessing the accounting principles used and significant estimates made by management, as well as evaluating the overall financial statement presentation. We believe that our audits provide a reasonable basis for our opinion. In our opinion, the financial statements referred to above present fairly, in all material respects, the consolidated financial position of Eli Lilly and Company and subsidiaries at December 31, 1998 and 1997, and the consolidated results of their operations and their cash flows for each of the three years in the period ended December 31, 1998, in conformity with generally accepted accounting principles. Ernst & Young LLP Indianapolis, Indiana January 30, 1999 28 Appendix to Exhibit 13 Graphs in Annual Report to Shareholders for the Year Ended December 31, 1998 Set forth below, converted to tabular format, are the graphs contained in the paper format of the portions of the Company's Annual Report to Shareholders that are contained in this Exhibit 13. Graph #1--Net Sales ($ millions) Year Amount - ---- ------- 1989 $3,391.0 1990 4,178.3 1991 4,533.4 1992 4,963.1 1993 5,198.5 1994 5,686.5 1995 6,508.8 1996 6,998.3 1997 7,987.7 1998 9,236.8 Net sales increased 16 percent as strong worldwide volume growth of 15 percent and a slight increase in global selling prices were partially offset by unfavorable exchange rates. Graph #2--Sales Growth ($ millions; percentages represent changes from 1997) Percent Change Class Amount from 1997 - ----- ------ ------------ Zyprexa $713.0 98% Prozac 257.0 10% Evista 144.0 N/M Gemzar 132.0 76% ReoPro 111.0 44% Humalog 62.0 91% Five of the company's newer products - Zyprexa, Evista, Gemzar, ReoPro and Humalog - generated $2.4 billion in sales in 1998 and 93 percent of the growth in sales. Prozac also continues to contribute to Lilly's sales growth. 29 Appendix to Exhibit 13 Continued Graph #3--Net Sales ($ millions; percentages represent changes from 1997) Percent Change Class Amount from 1997 - ----- ------------ --------------- Prozac $2,811.5 10% Zyprexa 1,442.7 98% Anti-Infectives 1,160.9 (9)% Insulins 1,154.9 8% Animal Health 614.4 4% Axid 418.0 (20)% ReoPro 365.4 44% Gemzar 306.8 76% Humatrope 268.0 3% Evista 144.1 N/M In 1998, sales of four of the company's newer products, Zyprexa, Evista, Gemzar, and ReoPro, and continued growth in sales of Prozac accounted for essentially all the 16 percent increase in net sales. In total, 16 products, spanning all therapeutic classes, had annual sales in excess of $100 million. Graph #4--Sales Outside the U.S. ($ millions) Year Amount - ---- ------ 1989 $1,335.7 1990 1,636.9 1991 1,807.0 1992 1,996.2 1993 2,097.5 1994 2,430.2 1995 2,950.9 1996 3,081.0 1997 3,105.9 1998 3,400.6 After 3 years of essentially flat international sales, the recent launches of Humalog, Zyprexa and Gemzar in many countries contributed to sales growth of 9 percent. Volume growth of 13 percent and price increases of 1 percent were somewhat offset by an adverse exchange rate impact of 5 percent. Graph #5--Research and Development ($ millions) Year Amount - ---- ------ 1994 $ 838.7 1995 1,042.3 1996 1,189.5 1997 1,370.2 1998 1,738.9 Worldwide research and development expenditures increased 27 percent in 1998, a greater rate than sales, in support of the company's strong pipeline, which includes 25 compounds in Phase II or Phase III clinical trials. 30 Appendix to Exhibit 13 Continued Graph #6--Return on Shareholders' Equity (Based on Income from Continuing Operations before Extraordinary Item) (percentage) Year Percent - ---- ------- 1994 23.8% 1995 26.1% 1996 28.2% 1997 37.5% 1998 46.2% Earnings growth, combined with measures to enhance shareholder value, such as the special share repurchase program, resulted in a significant increase in return on shareholders' equity. Graph #7--Economic Value Added ($ millions) Year Amount - ---- ------ 1995 $ 333 1996 460 1997 751 1998 1,429 In 1998, Lilly's Economic Valued Added (EVA) was $1.4 billion, an increase of 90 percent, reflecting the company's commitment to delivering exceptional shareholder value. Graph #8--Capital Expenditures ($ millions) Year Amount - ---- ------ 1994 $576.5 1995 551.3 1996 443.9 1997 366.3 1998 419.9 Capital expenditures increased 15 percent from the 1997 level primarily due to the increased support of various research initiatives and related infrastructure. The company expects near-term capital expenditures to increase from 1998 levels due to continuing investment in research and manufacturing capabilities. Graph #9--Dividends Paid per Share (dollars) Year Amount - ---- ------ 1994 $.625 1995 .655 1996 .685 1997 .740 1998 .800 31 Appendix to Exhibit 13 Continued Dividends paid during 1998 increased 8 percent over 1997. Nineteen ninety-eight was the 31st consecutive year in which dividends were increased. The continued earnings growth in 1998 enabled the company to declare a first-quarter 1999 dividend of $.23 per share, a 15 percent increase over 1998. The increase reflects the company's continued commitment to delivering shareholder value. 32

 
                 Exhibit 21-List of Subsidiaries and Affiliates

 The following are the subsidiaries and affiliated corporations of the Company
   at December 31, 1998. Certain subsidiaries have been omitted since they 
                     are not significant in the aggregate.

State or Jurisdiction of Incorporation or Organization ----------------------- ELI LILLY AND COMPANY (1) Indiana Eli Lilly International Corporation Indiana Eli Lilly Iran, S.A. Iran ELCO Insurance Company, Ltd. Bermuda Eli Lilly Interamerica, Inc. Indiana Eli Lilly do Brasil Limitada Brazil Elanco Quimica Limitada Brazil Darilor Sociedad Anonima Uruguay Beimirco Sociedad Anonima Uruguay Eli Lilly Interamerica Inc., y Compania Limitada Chile STC Pharmaceuticals, Inc. Indiana Idacorp Acquistion LLC Idaho Dista, Inc. Indiana Eli Lilly de Centro America, S.A. Guatemala Eli Lilly de Centro America, Sociedad Anonima Costa Rica Eli Lilly y Compania de Mexico, S.A. de C.V. Mexico Dista Mexicana, S.A. de C.V. Mexico Eli Lilly Industries, Inc. Delaware del Sol Financial Services, Inc. British V.I. Lilly del Caribe, Inc. Cayman Isls. Eli Lilly and Company (Taiwan), Inc. Taiwan Control Diabetes Services, Inc. Indiana PCS Holding Corporation Delaware Clinical Pharmaceuticals, Inc. Delaware Convenience Office Prescriptions California PCS Health Systems, Inc. Delaware PCS of New York, Inc. New York PCS Services, Inc. Delaware PCS Mail Services, Inc. Delaware Integrated Medical Systems, Inc. Colorado ELCO Dominicana, S.A. Dominican Rep. ELCO International Sales Corporation Virgin Is.-US
Page 1 Exhibit 21-List of Subsidiaries and Affiliates The following are the subsidiaries and affiliated corporations of the Company at December 31, 1998. Certain subsidiaries have been omitted since they are not significant in the aggregate.
State or Jurisdiction of Incorporation or Organization ----------------------- ELI LILLY AND COMPANY (1) (Cont'd) Indiana Eli Lilly Group Limited England Eli Lilly & Co. LTD. England Dista Products Limited England Eli Lilly & Co (Ireland) Trustee Limited Ireland Lilly Industries England Lilly Research Centre Limited England Elanco Products Limited England Creative Packaging Limited England Greenfield Pharmaceuticals Limited England Lilly Medical Instruments Limited England Eli Lilly (Basingstoke) Limited England Eli Lilly UK Limited England Eli Lilly Group Pension Trustees Limited England Lilly Pharma Holding GmbH Germany Lilly Deutschland GmbH Germany Lilly Pharma Fertigung & Distribution GmbH Germany Lilly Pharma Produktion GmbH & Co. KG Germany Lilly Forschung GmbH Germany Eli Lilly Ges.m.b.H. Austria Eli Lilly & Co. (Ireland) Limited Ireland Eli Lilly Asia, Inc. Delaware Eli Lilly Australia Pty. Limited Australia Eli Lilly Australia Custodian Pty. Limited Bermuda Eli Lilly and Company (N.Z.) Limited New Zealand Eli Lilly (NZ)Staff Benefits Custodian Limited New Zealand Integrated Disease Management (NZ) Limited New Zealand E L Management Incorporated Delaware/Nova Scotia Eli Lilly Canada Inc. Canada Eli Lilly S.A. Switzerland Eli Lilly Export S.A. Switzerland GEMS Services, S.A. Belgium T. P. Eli Lilly and Elanco D.O.O. Yugoslavia Elanco Trustees Limited Ireland Kinsale Financial Services, Ltd. Ireland
Page 2 Exhibit 21-List of Subsidiaries and Affiliates The following are the subsidiaries and affiliated corporations of the Company at December 31, 1998. Certain subsidiaries have been omitted since they are not significant in the aggregate.
State or Jurisdiction of Incorporation or Organization ----------------------- ELI LILLY S.A. Switzerland Eli Lilly (Suisse) S.A. Switzerland Eli Lilly Vostok SA, Geneva Switzerland Eli Lilly MHC S.A.R.L. Switzerland Eli Lilly Mauritius Mauritius Oldfields Financial Management S.A. Switzerland Eli Lilly Suzhou Pharmaceutical Company Limited China Eli Lilly Nederland B.V. Netherlands Eli Lilly Regional GmbH Austria Lilly Development Centre S.A. Belgium Lilly Services S.A. Belgium Lilly Clinical Operations S.A. Belgium Eli Lilly CR s.r.o. Czech Repub. Eli Lilly Danmark A/S Denmark Eli Lilly Egypt Egypt OY Eli Lilly Finland Ab Finland Elco Participation, sarl France Lilly France S.A. France Elsa France, S.A. France ILCO sarl France Eli Lilly Italia S.p.A. Italy Dista Italia S.r.l. Italy Eli Lilly Benelux, S.A. Belgium Dista-Produtos Quimicos & Farmaceuticos,LDA Portugal Lilly-Farma, Produtos Farmaceuticos, Lda. Portugal Vitalfarma Portugal Pharmaserve - Lilly S.A.C.I. Greece Pharmabrand, S.A.C.I. Greece PRAXICO Ltd. Hungary Lilly Hungaria KFT Hungary Eli Lilly (Philippines), Incorporated Philippines Eli Lilly Ranbaxy Limited India Eli Lilly Israel Ltd. Israel Eli Lilly Japan K.K. Japan Lilly Korea LTD. Korea Elanco Animal Health, Korea, Ltd. Korea Eli Lilly Malaysia Sdn Bhd. Malaysia Damsen Trading Limited Malta Eli Lilly Maroc S.a.r.l. Morocco ELCO Production Services B.V. Netherlands Eli Lilly Norge A.S. Norway Eli Lilly Pakistan (Pvt.) Ltd. Pakistan Eli Lilly Polska Sp. z.o.o. (Ltd.) Poland Lilly Grodzisk Sp. z.o.o. Poland Vitalia Pharma Sp. Z.o.o. Poland Eli Lilly Asia Pacific Pte. Ltd. Singapore Lilly-NUS Centre for Clinical Pharmacology Pte. Ltd. Singapore Eli Lilly (S.A.) (Proprietary) Limited South Africa The Medikredit Joint Venture Partnership South Africa Medikredit Pty. Ltd. South Africa Elanco-Valquimica, S.A. Spain Dista, S.A. Spain Lilly, S.A. Spain Spaly Bioquimica, S.A. Spain Eli Lilly Sweden AB Sweden Lilly Ilac Ticaret A.S. Turkey Eli Lilly y Compania de Venezuela, S.A. Venezuela Dista Products & Compania Venezuela S.A. Venezuela
Page 3

 
                  EXHIBIT 23. CONSENT OF INDEPENDENT AUDITORS

We consent to the incorporation by reference in this Annual Report (Form 10-K) 
of Eli Lilly and Company of our report dated January 30, 1999, included in the 
1998 Annual Report to Shareholders of Eli Lilly and Company.

We also consent to the incorporation by reference in Registration Statement 
Number 33-29482 on Form S-8 dated June 23, 1989, in Registration Statement 
Number 33-37341 on Form S-8 dated October 17, 1990, in Registration Statement 
Number 33-58466 on Form S-3 dated February 17, 1993, in Registration Statement 
Number 33-50783 on Form S-8 dated October 27, 1993, in Registration Statement 
Number 33-56141 on Form S-8 dated October 24, 1994, in Registration Statement 
Number 333-02021 on Form S-8 dated March 28, 1996, in Registration Statement 
Number 333-62015 on Form S-8 dated August 21, 1998 and in Registration Statement
Number 333-66113 on Form S-8 dated October 26, 1998 of our report dated January 
30, 1999 with respect to the consolidated financial statements incorporated 
herein by reference in the Annual Report (Form 10-K) of Eli Lilly and Company.


Ernst & Young LLP

Indianapolis, Indiana
March 26, 1999



 


 
5 YEAR DEC-31-1998 JAN-01-1998 DEC-31-1998 1,495,741 101,385 2,032,138 64,263 999,894 5,406,760 7,274,449 3,178,183 12,595,494 4,607,243 2,185,501 0 0 686,497 3,743,071 12,595,494 8,807,831 9,236,755 1,601,436 2,015,040 4,524,712 0 181,278 2,664,991 568,657 2,096,334 8,770 (7,249) 0 2,097,855 1.91 1.87
 


 
5 YEAR DEC-31-1996 JAN-01-1996 DEC-31-1996 813,678 141,407 1,556,990 82,351 881,397 3,891,285 7,096,400 2,789,429 14,307,170 4,222,193 2,516,484 0 0 355,564 5,744,576 14,307,170 6,974,347 6,998,295 1,848,282 1,872,071 3,081,901 0 288,062 2,131,272 505,622 1,625,650 (102,180) 0 0 1,523,470 1.39 1.36
 


 
5 1,000 3-MOS DEC-31-1997 JAN-01-1997 MAR-31-1997 1,042,119 75,361 1,620,415 66,336 876,264 4,275,747 7,002,555 2,808,226 14,513,618 4,061,749 2,509,649 0 0 355,564 6,213,909 14,513,618 1,833,779 1,841,089 449,151 455,271 757,833 0 60,375 591,274 140,635 450,639 (18,023) 0 0 432,616 .39 .38
 


 
5 1,000 6-MOS DEC-31-1997 JAN-01-1997 JUN-30-1997 1,853,011 100,138 1,449,845 62,019 945,831 4,992,080 7,039,912 2,883,445 12,288,903 3,699,847 2,501,817 0 0 355,564 4,314,379 12,288,903 3,686,827 3,700,768 889,356 901,320 1,732,375 0 122,499 1,663,625 576,927 1,086,698 (2,386,178) 0 0 (1,299,480) (1.18) (1.15)
 


 
5 1,000 9-MOS DEC-31-1997 JAN-01-1997 SEP-30-1997 1,504,144 36,775 1,641,117 61,444 914,719 4,609,102 7,023,242 2,928,055 11,819,157 3,647,031 2,343,798 0 0 702,020 3,688,873 11,819,157 5,710,040 5,729,708 1,366,795 1,384,257 2,640,486 0 179,467 2,283,484 732,567 1,550,917 (2,393,480) 0 0 (842,563) (.77) (.75)
 


 
5 1,000 YEAR DEC-31-1997 JAN-01-1997 DEC-31-1997 1,947,541 77,101 1,597,675 53,330 900,730 5,320,736 7,034,880 2,933,155 12,577,436 4,191,617 2,326,110 0 0 694,701 3,950,911 12,577,436 7,962,218 7,987,683 1,922,783 1,946,023 3,701,126 0 232,736 2,901,115 885,251 2,015,864 (2,400,994) 0 0 (385,130) (.35) (.34)
 


 
5 1,000 3-MOS DEC-31-1998 JAN-01-1998 MAR-31-1998 1,327,825 63,137 1,729,728 59,339 977,769 4,779,014 7,014,914 2,973,169 12,046,750 3,530,461 2,337,204 0 0 692,037 4,101,326 12,046,750 2,083,646 2,087,032 453,588 457,278 906,426 0 47,924 703,429 171,754 531,675 (3,338) (7,249) 0 521,088 .47 .46
 


 
5 1,000 6-MOS DEC-31-1998 JAN-01-1998 JUN-30-1998 1,315,178 67,560 1,701,127 51,086 985,211 4,798,014 7,091,722 3,046,976 11,868,651 3,446,914 2,307,491 0 0 688,887 3,952,711 11,868,651 4,242,066 4,242,066 935,874 935,874 1,960,504 0 90,620 1,350,666 328,115 1,022,551 (2,870) (7,249) 0 1,021,432 .92 .90
 


 
5 1,000 9-MOS DEC-31-1998 JAN-01-1998 SEP-30-1998 1,543,501 72,940 1,858,034 61,357 1,028,456 5,329,856 7,162,996 3,117,402 12,581,264 4,007,853 2,268,891 0 0 686,242 3,822,757 12,581,264 6,601,465 6,601,465 1,431,659 1,431,659 3,195,519 0 135,976 1,949,655 414,938 1,534,717 3,061 (7,249) 0 1,530,529 1.39 1.36

 
EXHIBIT 99.  CAUTIONARY STATEMENT UNDER PRIVATE SECURITIES
             LITIGATION REFORM ACT OF 1995 -  "SAFE HARBOR" FOR
             FORWARD LOOKING DISCLOSURES


Certain forward-looking statements are included in this Form 10-K and may be
made by Company spokespersons based on current expectations of management.  All
forward-looking statements made by the Company are subject to risks and
uncertainties.  Certain factors, including but not limited to those listed
below, may cause actual results to differ materially from current expectations
and historical results.

 .    Competitive factors, including generic competition as patents on key
     products, such as Prozac, expire; pricing pressures, both in the U.S. and
     abroad, primarily from managed care groups and government agencies; and new
     patented products or expanded indications for existing products introduced
     by competitors, which can lead to declining demand for the Company's
     products.

 .    Changes in inventory levels maintained by pharmaceutical wholesalers as a
     result of wholesaler buying patterns, which can cause reported sales for a
     particular period to differ significantly from underlying prescriber
     demand.

 .    Economic factors over which the Company has no control, including changes
     in inflation, interest rates and foreign currency exchange rates, and
     overall economic conditions in volatile areas such as Latin America.

 .    Governmental factors, including laws and regulations and judicial decisions
     at the state and federal level related to Medicare, Medicaid and health
     care reform that could adversely affect pricing and reimbursement of the
     Company's products; and laws and regulations affecting international
     operations.

 .    The difficulties and uncertainties inherent in new product development. New
     product candidates that appear promising in development may fail to reach
     the market or may have only limited commercial success because of efficacy
     or safety concerns, inability to obtain necessary regulatory approvals,
     difficulty or excessive costs to manufacture, or infringement of the
     patents or intellectual property rights of others.

 .    Delays and uncertainties in the FDA approval process and the approval
     processes in other countries, resulting in lost market opportunity.

 .    Unexpected safety or efficacy concerns arising with respect to marketed
     products, whether or not scientifically justified, leading to product
     recalls, withdrawals or declining sales.

 .    Legal factors including unanticipated litigation of product liability or
     other liability claims; antitrust litigation; environmental matters; and
     patent disputes with competitors which could preclude commercialization of
     products or negatively affect the profitability of existing products. In
     particular, while the Company believes that its U.S. patents on Prozac are
     valid 

 
     and enforceable, there can be no assurance that the Company will
     prevail in the various legal challenges to those patents.

 .    Future difficulties obtaining or the inability to obtain existing levels of
     product liability insurance.

 .    Changes in tax laws, including laws related to the remittance of foreign
     earnings or investments in foreign countries with favorable tax rates, and 
     settlements of federal, state, and foreign tax audits.

 .    Changes in accounting standards promulgated by the Financial Accounting
     Standards Board, the Securities and Exchange Commission, and the American
     Institute of Certified Public Accountants which are adverse to the Company.

 .    Internal factors such as changes in business strategies and the impact of
     restructurings and business combinations.

 .    The Company's statement that it expects to complete the Year 2000
     modifications before December 31, 1999, is based on management's best
     estimate, which was derived utilizing numerous assumptions of future
     events, including the continued availability of certain resources, third
     party modification plans and other factors. However, there can be no
     guarantee that timely completion will be achieved and actual results could
     differ materially from those anticipated. Specific factors that might cause
     such material differences include, but are not limited to, the availability
     and cost of personnel trained in this area, the ability to locate and
     correct all relevant computer codes, and the successful completion by key
     third parties of their own Year 2000 modifications.