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                          SECURITIES AND EXCHANGE COMMISSION
                                Washington, D.C. 20549


                                     SCHEDULE 13D


                       Under the Securities Exchange Act of 1934
                                (Amendment No.      )*
                                               -----


                                     Seragen, Inc.
                                   (Name of Issuer)


                             Common Stock, $.01 par value
                            (Title of Class of Securities)


                                       817474-10-9
                                    (CUSIP Number)


              James B. Lootens, Assistant Secretary and Associate General
                                       Counsel,
                    Eli Lilly and Company, Lilly Corporate Center,
                       Indianapolis, Indiana 46285  317-276-5835

                     (Name, Address and Telephone Number of Person
                   Authorized to Receive Notices and Communications)

                                     April 7, 1997
                         (Date of Event which Requires Filing
                                  of this Statement)


          If the filing person has previously filed a statement on Schedule
          13G to report the acquisition which is the subject of this Schedule
          13D, and if filing this schedule because of Rule 13d-1(b)(3) or
          (4), check the following box   .
                                       --

          *The remainder of this cover page shall be filled out for a
          reporting person's initial filing on this form with respect to the
          subject class of securities, and for any subsequent amendment
          containing information which would alter disclosures provided in a
          prior cover page.

          The information required on the remainder of this cover page shall
          not be deemed to be "filed" for the purpose of Section 18 of the
          Securities Exchange Act of 1934 ("Act") or otherwise subject to the
          liabilities of that section of the Act but shall be subject to all
          other provisions of the Act (however, see the Notes).

          (Continued on following pages)

                           Page 1 of 34 Pages

          CUSIP No. 817474-10-9

   (1)     Names of Reporting Persons:             Eli Lilly and Company
           S.S. or I.R.S. Identification           35-0470950
           Nos. of Above Persons

   (2)     Check the Appropriate Box               (a)
           if a Member of a Group                  (b)
                                                   Not Applicable

   (3)     SEC Use Only

   (4)     Source of Funds                         WC, OO

   (5)     Check if Disclosure of Legal
           Proceedings is Required Pursuant
           to Items 2(d) or 2(e)                   Not Applicable

   (6)     Citizenship or Place of                 Indiana
           Organization

   Number of Shares        (7)  Sole Voting
     Beneficially Owned         Power              1,787,092
     by Each Reporting     (8)  Shared Voting      None
     Person With                Power
                           (9)  Sole Dispositive
                                Power              1,787,092
                          (10)  Shared Disposi-    None
                                tive Power

  (11)     Aggregate Amount Beneficially
           Owned by Each Reporting Person          1,787,092

  (12)     Check if the Aggregate Amount           Not Applicable
           In Row (11) Excludes Certain Shares

  (13)     Percent of Class Represented
           by Amount in Row (11)                   9.4%

  (14)     Type of Reporting Person                CO

                        Page 2 of 34 pages

          Item 1.  Security and Issuer.

                 This statement relates to the common stock, $.01 par value
          per share (the "Common Stock"), of Seragen, Inc., a Delaware
          corporation (the "Issuer").

                 The principal executive offices of the Issuer are located
          at 97 South Street, Hopkinton, Massachusetts  01748.

          Item 2.  Identity and Background.

                 This statement is filed by Eli Lilly and Company, an
          Indiana corporation ("Lilly").  Lilly's principal business and
          office address is Lilly Corporate Center, Indianapolis, Indiana
          46285.  Lilly is a global research-based corporation that
          develops, manufactures, and markets pharmaceuticals and animal
          health products and provides health-care management services.

                 Information with respect to the executive officers and
          directors of Lilly, including name, business address, present
          principal occupation or employment, and the name, principal
          business and address of any corporation or other organization in
          which such employment is conducted, is listed in Attachment 1
          which is incorporated in this Schedule 13D by reference.

                 Neither Lilly nor, to the best of its knowledge, any
          executive officer or director of Lilly, has during the last five
          years been convicted in a criminal proceeding (excluding traffic
          violations or similar misdemeanors) or been a party to a civil
          proceeding of a judicial or administrative body of competent
          jurisdiction and as a result of that proceeding was or is subject
          to a judgment, decree, or final order enjoining future violations
          of, or prohibiting or mandating activities subject to, federal or
          state securities laws or finding any violation with respect to
          those laws.

          Item 3.  Source and Amount of Funds or Other Consideration.

                 Lilly acquired 1,000,000 shares of Common Stock pursuant
          to a Stock Purchase Agreement effective as of April 7, 1997, (the
          ``Stock Purchase Agreement''), a copy of which is filed herewith
          as Exhibit A.  The consideration for the purchase of the Common
          Stock was Lilly's agreement to enter into an Amendment to Sales
          and Distribution Agreement and Development Agreement (the
          ``Amendment''), which was also entered into on April 7, 1997.
          Pursuant to the Amendment, in exchange for the shares of Common
          Stock Lilly agreed, among other things, to relinquish certain
          options granted to it by the Issuer in 1994 which gave Lilly
          rights to pursue the development of the Issuer's IL-2 Fusion
          Protein investigational compound for indications other than
          cancer and to pursue development of other compounds of the
          Issuer.  Lilly also agreed, subject to certain conditions, to pay
          up to $4,300,000 on behalf of the Issuer to assist the Issuer in
          meeting certain obligations to a third party under a license
          agreement.  The source of these funds is Lilly's working capital.

          Item 4.  Purpose of Transaction.

                 The Common Stock was acquired by Lilly for investment
          purposes, in connection with the execution of the Amendment,
          which defined certain rights and responsibilities of the Issuer
          and Lilly under an ongoing collaboration to develop the Issuer's
          IL-2 Fusion Protein investigational compound.

                          Page 3 of 34 pages

                 Lilly has no present plans or proposals which relate to or
          would result in:

                (a)   the acquisition by any person of additional
                      securities of the Issuer, or the disposition of
                      securities of the Issuer;

                (b)   an extraordinary corporate transaction, such
                      as a merger, reorganization or liquidation,
                      involving the Issuer or any of its
                      subsidiaries;

                (c)   a sale or transfer of a material amount of
                      assets of the Issuer or any of its
                      subsidiaries;

                (d)   any change in the present board of directors or
                      management of the Issuer including any plans or
                      proposals to change the number or term of
                      directors or to fill any existing vacancies on
                      the board;

                (e)   any material change in the present
                      capitalization or dividend policy of the
                      Issuer;

                (f)   any other material change in the Issuer's
                      business or corporate structure;

                (g)   changes in the Issuer's charter, bylaws, or
                      instruments corresponding thereto or other
                      actions which may impede the acquisition of
                      control of the Issuer by any person;

                (h)   causing a class of securities of the Issuer to
                      be delisted from a national securities exchange
                      or to cease to be authorized to be quoted in an
                      inter-dealer quotation system of a registered
                      national securities association;

                (i)   a class of equity securities of the Issuer
                      becoming eligible for termination of
                      registration pursuant to Section 12(g)(4) of
                      the Act; or

                (j)   any action similar to any of those enumerated
                      above.

          Item 5.  Interest in Securities of the Issuer.

                 (a)  Lilly is the beneficial owner of 1,787,092
                      shares of Common Stock of the Issuer, which is
                      9.4% of the number of shares of Common Stock
                      currently issued, outstanding, and entitled to
                      vote.

                      To the best knowledge of Lilly, no executive
                      officer or director of Lilly beneficially owns
                      any shares of Common Stock of the Issuer or has
                      a right to acquire any shares of Common Stock
                      of the Issuer.

                 (b)  Lilly has the sole power to vote or direct the
                      vote and to dispose and direct the disposition
                      of all shares of Common Stock issued to Lilly.

                      To the best knowledge of Lilly, no executive
                      officer or director of Lilly has the power to
                      vote or direct the vote or to dispose or direct

                            Page 4 of 34

                      the disposition of any shares of Common Stock
                      of the Issuer.

                (c)   Except for the acquisition of Common Stock by
                      Lilly described in response to Item 3 hereof,
                      neither Lilly nor, to the best knowledge of
                      Lilly, any executive officer or director of
                      Lilly has effected any transaction in the
                      Common Stock of Issuer during the past 60 days.

                (d)   No other person has the right to receive or
                      the power to direct the receipt of dividends
                      from, or the proceeds from the sale of, the
                      Common Stock issued to Lilly.

                (e)   Not applicable.

          Item 6.  Contracts, Arrangements, Understandings or Relationships
          With Respect to Securities of the Issuer.

                 The 1,000,000 shares of Common Stock were purchased from
          the Issuer on April 7, 1997, pursuant to the Stock Purchase
          Agreement dated April 7, 1997.  A copy of the Stock Purchase
          Agreement is attached to this Schedule 13D as Exhibit A.

                 On August 6, 1994, Lilly acquired 787,092 shares of Common
          Stock pursuant to a Stock Purchase Agreement dated that same date
          (the ``August 1994 Agreement''), a copy of which is incorporated
          by reference as an exhibit hereto.  Both Agreements include
          customary representations and warranties as well as post-closing
          covenants obligating the Issuer to (i) use best efforts to make
          available to Lilly the benefit of Rule 144 under the Securities
          act of 1933 (the "Securities Act'') for the resale of Common
          Stock held by Lilly; and (ii) at Lilly's election, register for
          resale under the Securities Act shares of Common Stock held by
          Lilly at such time as the Issuer engages in certain registered
          public offerings of its equity securities.

                 Except as set forth above, there are no contracts,
          arrangements, understandings or relationships between Lilly or,
          to the best of its knowledge, any executive officer or director
          of Lilly, and any other person with respect to any securities of
          the Issuer, including any contract, arrangement, understanding or
          relationship concerning the transfer or the voting of any
          securities of the Issuer, finder's fees, joint ventures, loan or
          option arrangements, puts or calls, guarantees of profits,
          division of profits or loss, or the giving or withholding of
          proxies.

          Item 7.  Material to Be Filed as Exhibits.

                 Exhibit A.  Stock Purchase Agreement dated April 7, 1997,
          between Seragen, Inc. and Eli Lilly and Company.

                 Exhibit B.  Stock Purchase Agreement dated August 6, 1994,
          between Seragen, Inc. and Eli Lilly and Company.

                         Page 5 of 34 pages

                                  SIGNATURE

                 After reasonable inquiry and to the best of my knowledge
          and belief, I certify that the information set forth in this
          statement is true, complete and correct.

                                             ELI LILLY AND COMPANY


                                             BY: s/Edwin W. Miller
                                                Edwin W. Miller
                                                Vice President and
                                                Treasurer


          Date:  April 11, 1997

                          Page 6 of 34 pages
                                                               Attachment 1


                                  DIRECTORS

         Name and Business Address
         (all business addresses are
         Lilly Corporate Center
         Indianapolis, Indiana 46285       Present Principal
         unless otherwise indicated)       Occupation or Employment

         Evan Bayh                         Partner, Baker & Daniels law firm
         300 N. Meridian St., Suite 2700
         Indianapolis, IN  46204

         Steven C. Beering, M.D.           President, Purdue University
         Purdue University
         West Lafayette, Indiana 47907

         James W. Cozad                    Retired Chairman of the Board and
         205 N. Michigan Avenue            Chief Executive Officer,
         Suite 4310                        Whitman Corporation   
         Chicago, Illinois  60601          

         Alfred G. Gilman, M.D., Ph.D.     Regental Professor and Chairman,
         5323 Harry Hines Blvd.            Dept. of Pharmacology, The
         Dallas, TX  75235-9041            University of Texas Southwestern
                                           Medical Center

         Charles E. Golden*                Executive Vice Presiden and
                                           Chief Financial Officer of
                                           Lilly

         Karen N. Horn, Ph.D.              Senior Managing Director and Head
         280 Park Avenue, 3 East           of International Private Banking,
         New York, NY  10017               Bankers Trust Company

         J. Clayburn La Force, Jr., Ph.D.  Dean Emeritus, The John E. Anderson
         P. O. Box 1595                    Graduate School of Management at
         Pauma Valley, CA  92061           UCLA

         Kenneth L. Lay, Ph.D.             Chairman and Chief
         P. O. Box 1188                    Officer, Enron Corp.
         Houston, TX  77251-1188

         Franklyn G. Prendergast,          Edmond and Marion Guggenheim
         M.D., Ph.D.                       Professor of Biochemistry
         Dept. of Pharmacology             Molecular Biology and Director,
         Mayo Foundation                   Mayo Cancer Center 
         200 First St., SW 
         Rochester, Minnesota  55905

                          Page 7 of 34 Pages

      Kathi P. Seifert                          Group President, North American
      2100 Winchester Road                      Personal Care Products,
      Neenah, Wisconsin  54956                  Kimberly-Clark Corporation

      Sidney Taurel*                            President and Chief Operating
                                                Officer of Lilly

      Randall L. Tobias*                        Chairman of the Board and
                                                Chief Executive Officer
                                                of Lilly

      August M. Watanabe, M.D.*                 Executive Vice President,
                                                Science and Technology of
                                                Lilly

      Alva O. Way                               Chairman of the Board,
      One State Street                          IBJ Schroder Bank & Trust
      New York, New York  10004                 Company

      *Executive officer of Lilly

                         Page 8 of 34 pages

 EXECUTIVE OFFICERS (who are not Directors)


 Name and Business Address
 (all business addresses are
 Lilly Corporate Center
 Indianapolis, Indiana 46285)   Present Principal Occupation or Employment

 Mitchell E. Daniels, Jr.       Vice President, Corporate Strategy and Policy

 Rebecca O. Goss                Vice President and General Counsel

 Pedro P. Granadillo            Vice President, Human Resources

 Alan S. Clark                  President, U. S. Operations

 Michael L. Eagle               Vice President, Manufacturing

 Brendan P. Fox, D.V.M.         President, Elanco Animal Health Business Unit

 Michael E. Hanson              President, Internal Medicine Business Unit

 James A. Harper                President, Endocrine Business Unit

 Gerhard N. Mayr                President, European, Middle East
                                    and African Operations

 Robert N. Postlethwait         President, Neuroscience Business Unit

 William R. Ringo, Jr.          President, Infectious Diseases
                                  Business Unit

 Gino Santini                   Vice President, Corporate Strategy
                                  and Business Development

 Thomas Trainer                 Vice President, Information Technology,
                                  and Chief Information Officer


                    Page 9 of 34 Pages


                                    Exhibit Index

       Exhibit             Description                          Page

         A                 Stock Purchase Agreement dated        11
                           April 7, 1997  

         B                 Stock Purchase Agreement dated         *
                           August 6, 1994


          *Incorporated by reference from Exhibit 10.48 to the quarterly
          Report on Form 10-Q of Seragen, Inc., for the quarter ended June
          30, 1994.

                            Page 10 of 34 pages



                                                                  Exhibit A

                              STOCK PURCHASE AGREEMENT

                                   by and between

                                    SERAGEN, INC.

                                         and

                                ELI LILLY AND COMPANY


                                     April 1997

                          Page 11 of 34 pages

                                    SERAGEN, INC.

                              STOCK PURCHASE AGREEMENT

              THIS STOCK PURCHASE AGREEMENT (this "Agreement") is
          made this 7th day of April, 1997 by and between Seragen,
          Inc., a Delaware corporation (the "Company"), and Eli Lilly
          and Company, an Indiana corporation ("Lilly").

              WHEREAS, the Company and Lilly are entering into an
          Amendment to Sales and Distribution Agreement and
          Development Agreement (the "Amendment") of even date 
          herewith;

              WHEREAS, the Company desires to issue and sell to Lilly
          and Lilly desires to acquire 1,000,000 shares (the "Shares")
          of the Company's Common Stock, par value $.01 per share
          ("Common Stock"); and

              WHEREAS, the Company and Lilly desire to set forth
          certain matters to which they have agreed relating to the
          Shares;

              NOW THEREFORE, in consideration of the premises and the
          mutual covenants contained in this Agreement the parties
          agree as follows:

                      ARTICLE I - ISSUANCE AND TERMS OF SHARES

              SECTION 1.1  Authorization of Shares.  Subject to the
          terms and conditions of this Agreement, the Company has
          authorized the sale of the Shares pursuant to this
          Agreement.

              SECTION 1.2  Purchase and Sale of Shares.  Subject to
          the terms and conditions of this Agreement and in reliance
          upon the representations and warranties of the Company and
          Lilly contained herein, Lilly agrees to purchase the Shares
          from the Company and the Company agrees to sell the Shares
          to Lilly on the Closing Date in consideration for Lilly's
          agreement to enter into the Amendment with the Company.

              SECTION 1.3  Resale Limitations.  Lilly hereby agrees
          not to sell, pledge, assign or otherwise transfer the Shares
          for a period of one year following the date of issuance of
          the Shares, except with the prior consent of the Company,
          which consent shall not be unreasonably withheld; provided
          that Lilly shall have the right to transfer the Shares to
          its Affiliates (as defined in the Sales and Distribution
          Agreement dated as of August 3, 1994 between Lilly and the
          Company) during such one-year period without the prior
          consent of the Company and provided that those Affiliates
          agree in writing to be bound by the restrictions on the
          sale, pledge, assignment and transfer of the Shares set
          forth in this Section 1.3.

                                ARTICLE II - CLOSING

              SECTION 2.1  Closing.  Subject to the satisfaction of
          Articles V and VI hereof, the closing hereunder (the
          "Closing") shall take place at a place and time (the
          "Closing Date") mutually agreed by the Company and Lilly.
          At the Closing, the Company shall deliver to Lilly one or
          more stock certificates registered in the name of "Eli Lilly
          and Company," or in such name or names as may be designated
          by Lilly at least five business days in advance of the
          Closing Date, for the number of shares described in Section
          1.2 hereof, simultaneously with the execution and delivery
          by the parties of the Amendment.

              SECTION 2.2  Legend.  The certificates representing the
          Shares shall be subject to a legend restricting transfer
          under the Securities Act of 1933, as amended (the
          "Securities Act"), such legend to be substantially as
          follows:

                          Page 12 of 34 pages

               "THE SECURITIES EVIDENCED HEREBY HAVE NOT BEEN
               REGISTERED UNDER THE SECURITIES ACT OF 1933.  THESE
               SECURITIES MAY NOT BE SOLD OR OTHERWISE TRANSFERRED BY
               ANY PERSON UNLESS (1) EITHER (A) A REGISTRATION
               STATEMENT WITH RESPECT TO SUCH SECURITIES SHALL BE
               EFFECTIVE UNDER THE SECURITIES ACT OF 1933 ("ACT"), OR
               (B) THE COMPANY SHALL HAVE REASONABLY REQUESTED AND
               RECEIVED AN OPINION OF COUNSEL SATISFACTORY TO IT THAT
               AN EXEMPTION FROM REGISTRATION UNDER SUCH ACT IS THEN
               AVAILABLE, AND (2) THERE SHALL HAVE BEEN COMPLIANCE
               WITH ALL APPLICABLE STATE SECURITIES LAWS."

                ARTICLE III - REPRESENTATIONS AND WARRANTIES OF THE
                                    COMPANY

              The Company hereby represents and warrants to Lilly
          that, as of the date of this Agreement, except as otherwise
          described on Exhibit A hereto, the following are true and
          correct in all material respects:

              SECTION 3.1  Organization and Standing of the Company.
          The Company is a corporation duly organized, validly
          existing and in good standing under the laws of the State of
          Delaware and is duly qualified to transact business as a
          foreign corporation and is in good standing in each
          jurisdiction in which the conduct of its business or the
          ownership or leasing of properties requires such
          qualification.  The Company has the corporate power and
          authority (i) to own and lease its property, (ii) to enter
          into, deliver, and perform its obligations and undertakings
          under this Agreement, (iii) to issue the Shares, and (iv) to
          conduct its business in each of the jurisdictions in which
          such business is now conducted.  The Company has furnished
          to Lilly true and correct copies of its Certificate of
          Incorporation and By-laws, as currently in effect.

              SECTION 3.2  Subsidiaries.  Except as disclosed on
          Schedule 3.2 hereto the Company has no subsidiaries and does
          not control, directly or indirectly, any other corporation,
          association or business organization.

              SECTION 3.3  Capitalization.  The Company's entire
          authorized capital stock consists of: 70,000,000 shares of
          Common Stock and 5,000,000 shares of Preferred Stock, $.01
          par value per share (the "Preferred Stock").  All of the
          Company's outstanding shares of Common Stock and Preferred
          Stock, options and warrants are listed on Schedule 3.3
          hereto.  As of January 31, 1997, the Company had an
          aggregate of 1,832,281 shares of Common Stock available for
          issuance under the Company's 1992 Long Term Incentive Plan
          and 1992 Non-Employee Director Non-Qualified Stock Option
          Plan (the "Stock Plans"). The Common Stock and the Preferred
          Stock have the preferences, voting powers, qualifications,
          and special or relative rights or privileges set forth in
          Article IV of the Company's Certificate of Incorporation.
          All outstanding shares of Common Stock have been validly
          issued, are fully paid and non-assessable and have been
          issued in accordance with applicable federal and state
          securities laws.  In accordance with the Company's
          Certificate of Incorporation, as amended, the Shares, when
          issued, will be validly authorized, issued and outstanding,
          fully paid and non-assessable.  Other than as indicated on
          Schedule 3.3 hereto or in the SEC Reports (as hereinafter
          defined), the Company does not have outstanding any option,
          warrant, agreement or other commitment to issue or to
          acquire any shares of its capital stock, or any securities
          or obligations convertible into or exchangeable for its
          capital stock, and the Company has not given any person any
          right to acquire from the Company or sell to the Company any
          shares of its capital stock.  Except as indicated in the SEC
          Reports, there is, and immediately upon consummation at the
          Closing of the transactions contemplated hereby, there will
          be, no agreement, restriction or encumbrance (such as a
          right of first refusal, right of first offer, proxy, voting
          agreement, etc.) with respect to the sale or voting of any
          shares of capital stock of the Company (whether outstanding
          or issuable upon conversion or exercise of outstanding

                         Page 13 of 34 pages

          securities) to which the Company is a party except as
          contemplated by any provisions of the Company's Certificate
          of Incorporation or By-laws.  Notwithstanding the foregoing,
          there is no agreement, restriction or encumbrance (such as a
          right of first refusal, right of first offer, proxy, voting
          agreement, etc.) in effect with respect to the Shares or
          which will not have been waived prior to Closing.

              SECTION 3.4  Validity of this Agreement.  The
          execution, delivery and performance by the Company of this
          Agreement, and the issue and sale of the Shares have been
          duly authorized and approved by all necessary corporate
          action.  This Agreement has been duly executed and delivered
          and constitutes a valid and binding obligation of the
          Company, enforceable in accordance with its terms subject to
          laws of general application from time to time in effect
          affecting creditors' rights and the exercise of judicial
          discretion in accordance with general equitable principles.
          The execution, delivery and performance of the Agreement and
          the issuance and sale of the Shares will not conflict with,
          or result in any breach of any of the terms of, or
          constitute a default under, the Certificate of Incorporation
          or By-laws of the Company, or result in a material breach of
          any of the terms of, or constitute a material default under
          any agreement, instrument, covenant or other restriction to
          which the Company is a party or by which it or any of its
          properties or assets is bound.

              SECTION 3.5  Accuracy of Reports and Information.  The
          Company's Common Stock is registered pursuant to Section
          12(g) of the Securities Exchange Act of 1934, as amended
          (the "Exchange Act").  Except as described on Schedule 3.5,
          all reports (the "SEC Reports") required to be filed by the
          Company have been duly filed, were in compliance with the
          requirements of their respective forms and were complete and
          correct in all material respects as of the dates at which
          the information was furnished.  Copies of all SEC Reports
          filed by the Company during the period from March 1, 1993 to
          the date of this Agreement have been furnished to Lilly.
          The Company will continue to file all reports required to be
          filed under the Exchange Act.  Except as described on
          Schedule 3.5, the SEC Reports, do not contain any untrue
          statement of a material fact or omit to state a material
          fact necessary to make the statements made therein, in the
          light of the circumstances under which they were made, not
          misleading.

              SECTION 3.6  Financial Statements.  The audited
          financial statements of the Company contained in the
          Company's Annual Report on Form 10-K for the year ended
          December 31, 1996, including the notes relating thereto,
          have been prepared in accordance with generally accepted
          accounting principles consistently followed throughout the
          periods involved.  Said financial statements and related
          notes fairly present the financial position and the results
          of operations and cash flow of the Company as of the
          respective dates thereof and for the periods indicated, and
          disclose all material liabilities of the Company as of the
          respective dates thereof.  Since December 31, 1996 there has
          not been any change in the assets, properties, liabilities,
          financial condition, operating results or business of the
          Company, except for depletion of cash resources and changes
          in the ordinary course of business which have not been, in
          the aggregate, materially adverse.

              SECTION 3.7  Governmental Consent, etc.  Except for
          filings, consents, permits, approvals and authorizations
          which will be obtained by the Company prior to Closing, no
          consent, approval or authorization of any governmental
          authority is required under existing law or regulation in
          connection with the execution and delivery of the Agreement
          or the offer, issue, sale or delivery of the Shares pursuant
          to the Agreement or the consummation of any other
          transactions contemplated thereby.

                        Page 14 of 34 pages

              SECTION 3.8  Compliance with Other Agreements and
          Instruments.  Except as reflected in the SEC Reports, the
          Company is not in violation of any provisions of its
          Certificate of Incorporation or By-laws, or, to the best of
          the Company's knowledge, of any provision of any Federal or
          state judgment, writ, decree, order, statute, rule or
          governmental regulation applicable to the Company, which
          violation materially and adversely affects the business or
          financial condition of the Company.  The Company is not in
          material violation or default of any agreement, instrument
          or contract to which it is a party or by which it or its
          property is bound, which violation materially and adversely
          affects the business or financial condition of the Company.

              SECTION 3.9  Valid Issuance of Shares.  When issued and
          delivered against payment therefor in accordance with the
          terms of this Agreement, the Shares shall be duly authorized
          and validly issued (including, without limitation, issued in
          compliance with applicable federal and state securities
          laws), fully paid and non-assessable and not subject to any
          preemptive rights, liens, claims or encumbrances, or other
          restriction on transfer, except as set forth in this
          Agreement.

              SECTION 3.10  Private Offering.  Neither the Company
          nor, to the Company's best knowledge, anyone acting on its
          behalf has offered any securities of the Company for
          issuance or sale to, or solicited any offer to acquire any
          of the same from, any person or entity so as to make the
          issuance and sale of the Shares subject to the registration
          requirements of Section 5 of the Securities Act of 1933, as
          amended ("Securities Act").

              SECTION 3.11  Registration Rights.  Except as set forth
          in Exhibit A and as provided in this Agreement, the Company
          is under no contractual obligation to register (now or in
          the future, whether contingent or not) under the Securities
          Act any of its presently outstanding securities or any of
          its securities that may subsequently be issued.

              SECTION 3.12  Full Disclosure.  The Company believes it
          has provided Lilly with all information that Lilly has
          requested for deciding whether to purchase the Shares.
          Neither this Agreement nor any other statements or
          certificates made or delivered in connection herewith
          contain any untrue statement of a material fact or omit to
          state a material fact necessary to make the statements made
          therein, in light of the circumstances under which they were
          made, not misleading.

                ARTICLE IV - REPRESENTATIONS AND WARRANTIES OF LILLY

              Lilly hereby acknowledges, represents, warrants and
          agrees as follows:

              SECTION 4.1  Authority of Lilly; Validity of this
          Agreement.  Lilly has all requisite power and authority to
          enter into this Agreement and perform its obligations
          hereunder.  The execution, delivery and performance by Lilly
          of this Agreement, and the purchase of the Shares have been
          duly authorized and approved by all necessary corporate
          action.  This Agreement has been duly executed and delivered
          and constitutes a valid and binding obligation of Lilly,
          enforceable in accordance with its terms, subject to laws of
          general application from time to time in effect affecting
          creditors' rights and the exercise of judicial discretion in
          accordance with general equitable principles.  The
          execution, delivery and performance of this Agreement and
          the purchase of the Shares will not conflict with, or result
          in a material breach of any of the terms of, or constitute a
          material default under, any charter, by-law, agreement,
          instrument, covenant or other restriction to which Lilly is
          a party or by which it or any of its properties or assets is
          bound.

                          Page 15 of 34 pages

              SECTION 4.2  Investment Representations.  Lilly hereby
          acknowledges, represents, warrants and agrees as follows:

              Lilly has reviewed the SEC Reports and the financial
          statements contained therein.  Lilly acknowledges that the
          Company has made available to Lilly all documents and
          information that it has requested relating to the Company
          and has provided answers to all of its questions concerning
          the Company and the Shares.  In evaluating the suitability
          of the acquisition of the Shares hereunder, Lilly has not
          relied upon any representations or other information
          (whether oral or written) other than as set forth in the SEC
          Reports or as contained herein.

              Lilly is an "accredited investor" as defined in Rule
          501(a)(3) of the Securities Act.

              Lilly understands that the offering of the Shares has
          not been registered under the Securities Act or the
          securities laws of any state or other jurisdiction and that
          such Shares must be held indefinitely unless an exemption
          from registration is available.  Lilly understands that the
          offering and sale of the Shares is intended to be exempt
          from registration under the Securities Act, by virtue of
          Section 4(2) and/or Section 4(6) of the Securities Act and
          the provisions of Regulation D promulgated thereunder,
          based, in part, upon the representations, warranties and
          agreements of Lilly contained in this Agreement and the
          Company may rely on such representations, warranties and
          agreements in connection therewith.  Lilly will not transfer
          the Shares in violation of the provisions of any applicable
          Federal or state securities statute.

              Lilly is acquiring the Shares for investment, and not
          with a view to the resale or distribution thereof; it has no
          present intention of selling, negotiating, or otherwise
          disposing of the Shares.  Lilly's financial condition and
          investments are such that it is in a financial position to
          hold the Shares for an indefinite period of time and to bear
          the economic risk of, and withstand a complete loss of, such
          Shares.  In addition, by virtue of its expertise, the advice
          available to it, and its previous investment experience,
          Lilly has extensive knowledge and experience in financial
          and business matters, investments, securities, and private
          placements and the capability to evaluate the merits and
          risks of the transactions contemplated by this Agreement.

                   ARTICLE V - CONDITIONS TO LILLY'S OBLIGATIONS

              The obligation of Lilly to purchase and pay for the
          Shares is subject to the following:

              SECTION 5.1  Representations and Warranties.  The
          representations and warranties of the Company made herein
          shall be true, correct and complete in all material respects
          on and as of the Closing Date with the same force and effect
          as if they had been made on and as of the Closing Date.

              SECTION 5.2  Performance.  All covenants, agreements
          and conditions contained in this Agreement to be performed
          or complied with by the Company on or prior to the Closing
          Date shall have been performed or complied with in all
          material respects.

              SECTION 5.3  Opinion of Company's Counsel.  Lilly shall
          have received an opinion of Mintz, Levin, Cohn, Ferris,
          Glovsky and Popeo, P.C., counsel for the Company,
          substantially in the form of Exhibit B hereto.

              SECTION 5.4  Corporate Proceedings; Consents, Etc.  All
          corporate and other proceedings to be taken and all waivers
          and consents to be obtained in connection with the
          transactions contemplated by this Agreement shall have been

                         Page 16 of 34 pages

          taken or obtained and all documents incident thereto shall
          be reasonably satisfactory in form and substance to Lilly
          and its counsel, each of whom shall have received all such
          originals or certified or other copies of such documents as
          each may reasonably request.

              SECTION 5.5  No Order Pending.  There shall not then be
          in effect any order enjoining or restraining the
          transactions contemplated by this Agreement.

              SECTION 5.6  No Law Prohibiting or Restricting such
          Sale.  There shall not be in effect any law, rule or
          regulation prohibiting or restricting such sale, or
          requiring any consent or approval of any person which shall
          not have been obtained to issue the Shares (except as
          otherwise provided in this Agreement).

              SECTION 5.7  Officer's Certificate.  The Company shall
          have delivered to Lilly a certificate, dated the Closing
          Date and signed by the Chief Executive Officer or the
          President of the Company, to the effect that each of the
          conditions to be satisfied by the Company pursuant to this
          Article V on or before the Closing Date has been duly
          satisfied.

                ARTICLE VI - CONDITIONS TO THE COMPANY'S OBLIGATIONS

              The obligation of the Company to issue the Shares to
          Lilly is subject to the following:

              SECTION 6.1  Representations and Warranties.  The
          representations and warranties of Lilly made herein shall be
          true, correct and complete in all material respects on and
          as of the Closing Date with the same force and effect as if
          they had been made on and as of the Closing Date.

              SECTION 6.2  Execution of Amendment.  Lilly shall have
          executed and delivered to the Company the Amendment.

              SECTION 6.3  No Order Pending.  There shall not then be
          in effect any order enjoining or restraining the
          transactions contemplated by this Agreement.

              SECTION 6.4  No Law Prohibiting or Restricting such
          Sale.  There shall not be in effect any law, rule or
          regulation prohibiting or restricting such sale, or
          requiring any consent or approval of any person which shall
          not have been obtained to issue the Shares (except as
          otherwise provided in this Agreement).

              ARTICLE VII - POST CLOSING COVENANTS OF THE COMPANY

              SECTION 7.1  Rule 144 Reporting and SEC Form S-3.  With
          a view to making available the benefits of certain rules and
          regulations of the Commission which may at any time permit
          the sale of the Shares to the public without registration or
          a registration on SEC Form S-3, the Company agrees to use
          its best efforts to:

              (a)   Make and keep public information available, as
                    those terms are understood and defined in Rule 144
                    under the Securities Act;

              (b)   File with the Commission in a timely manner all
                    reports and other documents  required of the
                    Company under the Securities Act and the Exchange
                    Act;

              (c)   So long as Lilly owns any Shares, to furnish to
                    Lilly forthwith upon request (i) a written
                    statement by the Company as to whether it complies
                    with the reporting requirements of said Rule 144,
                    the Securities Act and the Exchange Act, or

                         Page 17 of 34 pages

                    whether it qualifies as a registrant whose
                    securities may be resold pursuant to SEC Form S-3,
                    (ii) a copy of the most recent annual or quarterly
                    report of the Company and such other reports and
                    documents so filed by the Company, and (iii) such
                    other information as may be reasonably requested
                    in availing Lilly of any rule or regulation of the
                    Commission which would permit the selling of the
                    Shares without registration.

              SECTION 7.2  Private Offering.  Neither the Company nor
          anyone acting on its behalf will offer any securities of the
          Company for issuance or sale to, or solicit any offer to
          acquire any of the same from, any person or entity so as to
          make the issuance and sale of the Shares subject to the
          registration requirements of Section 5 of the Securities
          Act.

              SECTION 7.3  Registration Rights.

              (a)   Definitions.  As used in this Section 7.3, the
                    following terms shall have the following
                    respective meanings:

                         "Commission" shall mean the Securities and
                         Exchange Commission or any other federal
                         agency at the time administering the
                         Securities Act.

                         "Transfer" shall mean any disposition of the
                         Shares which would constitute a sale thereof
                         within the meaning of the Securities Act.

                         "Restricted Securities" shall mean (i) the
                         Shares; and (ii) any common stock or other
                         security issued as a dividend or other
                         distribution with respect to the foregoing.

              (b)   Amendments of Registration Rights.  Without the
                    written consent of the holders of 51% of the total
                    number of shares which would, at the time of such
                    calculation, constitute Restricted Securities, the
                    Company shall not amend this Section 7.3, or enter
                    into any agreement with any holder or prospective
                    holder of any securities of the Company which
                    would grant to such holder or prospective holder
                    rights superior to or in conflict with any rights
                    conferred upon Lilly under this Section.

              (c)   "Piggyback" Registrations.  Commencing two years
                    from the Closing Date, if and whenever the Company
                    proposes to register any of its equity securities
                    under the Securities Act for an offering to the
                    general public for cash, whether on its own behalf
                    or on behalf of controlling shareholders of the
                    Company participating in a secondary distribution,
                    it will give written notice to all holders of
                    Restricted Securities of its intention to do so
                    and, upon the written request of the holders of
                    any Restricted Securities given within thirty (30)
                    days after the Company's giving of such notice
                    (which request shall state the intended method of
                    disposition of the securities by the prospective
                    sellers), the Company will use its best efforts to
                    cause the Restricted Securities as to which
                    registration shall have been so requested to be
                    included in the shares of securities to be covered
                    by the registration statement proposed to be filed
                    by the Company, all to the extent requisite to
                    permit the sale or other disposition (in
                    accordance with the written request of the
                    holders) by the prospective seller or sellers of
                    such Restricted Securities.  In the event that any
                    registration pursuant to this Subsection shall be,

                              Page 18 of 34 pages

                    in whole or in part, a firm commitment
                    underwritten offering of securities of the
                    Company, any request by such holders pursuant to
                    this Subsection to register Restricted Securities
                    must specify that such shares are to be included
                    in the underwriting on the same terms and
                    conditions as the shares of securities, if any,
                    otherwise being sold through underwriters under
                    such registration.  In the event that no shares of
                    securities are being sold through underwriters
                    under such registration, then any request by such
                    holders pursuant to this Subsection to register
                    such Restricted Securities must specify that such
                    shares are to be included in the registration on
                    terms and conditions comparable to those normally
                    applicable to offerings of common stock in
                    reasonably similar circumstances.  Notwithstanding
                    any other provision of this Section, if the
                    underwriter determines that marketing factors
                    require a limitation of the number of shares to be
                    underwritten or that it is otherwise advisable,
                    the underwriter may exclude the Restricted
                    Securities from such registration, provided,
                    however, except as otherwise required by
                    registration rights granted by the Company prior
                    to the date hereof, if any shares of Common Stock
                    are to be included in such registration for the
                    account of any person other than the Company, then
                    the number of Restricted Securities to be included
                    in such registration shall be determined pro rata
                    based upon the ratio of Restricted Securities
                    requested to be included in such registration to
                    the total number of shares of Common Stock
                    (including Restricted Securities) requested to be
                    included therein.

              (d)   Registration Procedures.  If and whenever the
                    Company is required by the provisions of this
                    Section to include any of the Restricted
                    Securities in a registration under the Securities
                    Act, Lilly will furnish in writing such
                    information as is reasonably requested by the
                    Company for inclusion in the registration
                    statement relating to such offering and such other
                    information and documentation as the Company shall
                    reasonably request, and the Company will, as
                    expeditiously as possible:

                   i.    Prepare and file with the Commission a
                         registration statement with respect to such
                         securities and use its best efforts to cause
                         such registration to become and remain
                         effective for such period as may be necessary
                         to permit the successful marketing of such
                         securities but not exceeding 120 days.

                   ii.   Prepare and file with the Commission such
                         amendments and supplements to such
                         registration statement and the prospectus
                         used in connection therewith as may be
                         necessary to comply with the provisions of
                         the Securities Act and to keep such
                         registration statement effective for that
                         period of time specified in paragraph
                         7.3(d)(i).

                   iii.  Furnish to each selling shareholder such
                         number of prospectuses and preliminary
                         prospectuses in conformity with the
                         requirements of the Securities Act, and such
                         other documents as such seller may reasonably
                         request in order to facilitate the public
                         sale or other disposition of the Restricted
                         Securities owned by such seller.

                   iv.   If the Company is required by the
                         underwriters, if any, of the securities
                         registered under this Section to deliver an

                           Page 19 of 34 pages

                         opinion of counsel to such underwriters in
                         connection with such registration, and if
                         requested by any holders of Restricted
                         Securities participating in such
                         registration, use its best efforts to furnish
                         such opinion to such holders on the day of
                         delivery to the underwriters, addressed to
                         such underwriters and to such holders.  Such
                         opinion shall be in such form as is customary
                         for similar opinions delivered by such
                         counsel.

                   v.    If the Company is required by the
                         underwriters, if any, of the securities
                         registered in a registration under this
                         Section to deliver a letter from the
                         independent certified public accountants of
                         the Company to such underwriters in
                         connection with such registration, and if
                         requested by any holders of Restricted
                         Securities participating in such
                         registration, use its best efforts to furnish
                         such letter to such holders on the day of
                         delivery to the underwriters, addressed to
                         such underwriters and to such holders,
                         providing substantially that such accountants
                         are independent certified public accountants
                         within the meaning of the Securities Act and
                         that in the opinion of such accountants, the
                         financial statements and other financial data
                         of the Company included in the registration
                         statement and the prospectus, and any
                         amendment or supplement thereto, comply as to
                         form in all material respects with the
                         applicable accounting requirements of the
                         Securities Act.  Such letter shall
                         additionally cover such other financial
                         matters (including information as to the
                         period ending not more than five business
                         days prior to the date of such letter) with
                         respect to the registration in respect of
                         which such letter is being given as the
                         holders of Restricted Securities requesting
                         such letter may reasonably request, and shall
                         be in such form as is customary for similar
                         letters delivered by such certified
                         independent public accountants.

                   vi.   Use its best efforts to register or qualify
                         the Restricted Securities covered by such
                         registration statement under such other
                         securities or blue sky laws of such
                         jurisdictions as each such selling
                         shareholder shall reasonably request and do
                         any and all other acts and things which may
                         be necessary or desirable to enable such
                         seller to consummate the public sale or other
                         disposition in such jurisdictions of the
                         Restricted Securities owned by such seller
                         and covered by such registration statement.

              (e)   Registration and Selling Expenses.  As used
                    herein, "Registration Expenses" shall mean all
                    expenses incurred by the Company in complying with
                    Subsection 7.3(c), including, without limitation,
                    all registration and filing fees; printing
                    expenses; fees and disbursements of counsel for
                    the Company; blue sky fees and expenses; and the
                    expense of any special audits incident to or
                    required by any such registration (but excluding
                    the compensation of regular employees of the
                    Company which shall be paid in any event by the
                    Company); and "Selling Expenses" shall mean all
                    underwriting discounts and selling commissions
                    applicable to the sales.  The Company will pay all
                    Registration Expenses in connection with the
                    registration pursuant to Subsection 7.3(c).  All
                    Selling Expenses in connection with each
                    registration pursuant to Subsection 7.3(c) shall

                             Page 20 of 34 pages

                    be borne by the Company and the selling
                    shareholders pro rata in proportion to the
                    securities covered thereby being sold by them.

              (f)   Standoff Agreement.  Purchaser agrees in
                    connection with any registration of the Company's
                    securities that, upon the request of the Company
                    or the underwriters managing any underwritten
                    offering of the Company's securities, not to sell,
                    make any short sale of, loan, grant any option for
                    the purchase of, or otherwise dispose of any
                    Restricted Securities (other than those included
                    in the registration) without the prior written
                    consent of the Company or such underwriters, as
                    the case may be, for such reasonable period of
                    time from the effective date of such registration
                    as the underwriters may specify, provided that all
                    officers and directors of the Company and all
                    holders of greater than ten (10%) percent of the
                    Common Stock enter into similar agreements.  Such
                    agreement shall be in writing and in a form
                    satisfactory to the Company and such underwriter.
                    The Company may impose stop-transfer instructions
                    with respect to the shares subject to the
                    foregoing restrictions until the end of such
                    period.

              (g)   Indemnification.  In the event of a registration
                    of any of the Restricted Securities under the
                    Securities Act pursuant to this Section, the
                    Company will indemnify and hold harmless the
                    seller of such Restricted Securities and each
                    underwriter of such Restricted Securities and each
                    other person, if any, who controls such seller or
                    underwriter within the meaning of Section 15 of
                    the Securities Act, against any and all losses,
                    claims, damages or liabilities, joint or several,
                    to which such seller or underwriter or controlling
                    person may become subject under the  Securities
                    Act or otherwise, insofar as such losses, claims,
                    damages or liabilities (or actions in respect
                    thereof) arise out of or are based upon any untrue
                    statement of any material fact contained on the
                    effective date thereof in any registration
                    statement under which such Restricted Securities
                    are registered under the Securities Act, any
                    preliminary prospectus or final prospectus
                    contained therein, or any amendment or supplement
                    thereof, or arise out of or are based upon the
                    omission or alleged omission to state therein a
                    material fact required to be stated therein or
                    necessary to make the statements therein not
                    misleading, and the Company will reimburse such
                    seller and each such underwriter and each such
                    controlling person for any legal or any other
                    expenses reasonably incurred by them in connection
                    with their investigating or defending any such
                    loss, claim, damage, liability or action;
                    provided, however, that the Company will not be
                    liable in any such case to the extent that any
                    such loss, claim, damage or liability arises out
                    of or is based upon an untrue statement or alleged
                    untrue statement or omission or alleged omission
                    made in such registration statement, said
                    preliminary prospectus or said prospectus or said
                    amendment or supplement in reliance upon and in
                    conformity with written information furnished to
                    the Company by such seller or underwriter
                    specifically for use in the preparation thereof;
                    and provided, further, that if any losses, claims,
                    damages or liabilities arise out of or are based
                    upon an untrue statement, alleged untrue
                    statement, omission or alleged omission contained
                    in any preliminary prospectus which did not appear
                    in the final prospectus, the Company shall not
                    have any liability with respect thereto to (i) the
                    seller or any person who controls such seller

                              Page 21 of 34 pages

                    within the meaning of Section 15 of the Securities
                    Act, if the seller delivered a copy of the
                    preliminary prospectus to the person alleging such
                    losses, claims, damages or liabilities and failed
                    to deliver a copy of the final prospectus, as
                    amended or supplemented if it has been amended or
                    supplemented, to such person at or prior to the
                    written confirmation of the sale to such person or
                    (ii) any underwriter or any person who controls
                    such underwriter within the meaning of Section 15
                    of the Securities Act, if such underwriter
                    delivered a copy of the preliminary prospectus to
                    the person alleging such losses, claims, damages
                    or liabilities and failed to deliver a copy of the
                    final prospectus, as amended or supplemented if it
                    has been amended or supplemented to such person at
                    or prior to the written confirmation of the sale
                    to such person.

                    In the event of any registration of any of the
                    Restricted Securities under the Securities Act
                    pursuant to this Section, each seller of such
                    Restricted Securities, severally and not jointly,
                    will indemnify and hold harmless the Company and
                    each person, if any, who controls the Company
                    within the meaning of Section 15 of the Securities
                    Act, each officer of the Company who signs the
                    registration statement, each director of the
                    Company, each underwriter and each person who
                    controls any underwriter within the meaning of
                    Section 15 of the Securities Act, against any and
                    all such losses, claims, damages or liabilities
                    referred to in the first paragraph of this
                    Subsection, if the statement, alleged statement,
                    omission or alleged omission in respect of which
                    such loss, claim, damage or liability is asserted
                    was made in reliance upon and in conformity with
                    information furnished in writing to the Company by
                    or on behalf of such seller specifically for use
                    in connection with the preparation of such
                    registration statement, preliminary prospectus,
                    prospectus, amendment or supplement; provided,
                    however, that if any losses, claims, damages or
                    liabilities arise out of or are based upon any
                    untrue statement, alleged untrue statement,
                    omission or alleged omission contained in any
                    preliminary prospectus which did not appear in the
                    final prospectus, such seller shall not have any
                    such liability with respect thereto to the
                    Company, any person who controls the Company
                    within the meaning of Section 15 of the Securities
                    Act, any officer of the Company who signed the
                    registration statement or any director of the
                    Company, if the Company delivered a copy of the
                    preliminary prospectus to the person alleging such
                    losses, claims, damages or liabilities and failed
                    to deliver a copy of the final prospectus, as
                    amended or supplemented if it has been amended or
                    supplemented, to such person at or prior to the
                    written confirmation of the sale to such person.

              (h)   Promptly after receipt by any indemnified person
                    of a notice of a claim or the beginning of any
                    action in respect of which indemnity is to be
                    sought against an indemnifying person pursuant to
                    Subsection 7.3(g), such indemnified person shall
                    notify the indemnifying person in writing of such
                    claim or of the commencement of such action, and,
                    subject to the provisions hereinafter stated, in
                    case any such action shall be brought against an
                    indemnified person and such indemnifying person

                             Page 22 of 34 pages

                    shall have been notified thereof, such
                    indemnifying person shall be entitled to
                    participate therein, and, to the extent that it
                    shall wish, to assume the defense thereof, with
                    counsel reasonably satisfactory to such
                    indemnified person.  After notice from the
                    indemnifying person to such indemnified person of
                    its election to assume the defense thereof, such
                    indemnifying person shall not be liable to such
                    indemnified person for any legal expenses
                    subsequently incurred by such indemnified person
                    in connection with the defense thereof; provided,
                    however, that if there exists or shall exist a
                    conflict of interest that would make it
                    inappropriate in the reasonable judgment of the
                    indemnified person for the same counsel to
                    represent both the indemnified person and such
                    indemnifying person or any affiliate or associate
                    thereof, the indemnified person shall be entitled
                    to retain its own counsel at the expense of such
                    indemnifying person; provided, further, however
                    that if the Company is the indemnifying party, it
                    shall not be required to pay the fees and expenses
                    of more than one counsel for all of the sellers.

              (i)   Termination Of Conditions And Obligations.
                    Except for the Company's indemnification
                    obligation contained in Subsection 7.3(g), the
                    obligations and conditions precedent imposed by
                    this Section shall cease and terminate as to any
                    of such Restricted Securities on the sooner of (i)
                    the date such securities shall have been
                    effectively registered under the Securities Act
                    and sold or otherwise disposed of in accordance
                    with the intended method of disposition by the
                    seller or sellers thereof set forth in the
                    registration statement covering such securities,
                    (ii) such time as Lilly has sold or transferred
                    the Shares pursuant to Rules 144 or 144A of the
                    Act, or (iii) five years from the date hereof.

              (j)   Transfer Of Registration Rights.  The rights
                    conferred upon Lilly under this Section may be
                    assigned by Lilly to any one or more transferees
                    of Restricted Securities, provided that such
                    transferee purchases fifty (50%) percent or more
                    of the Shares.

               SECTION 7.4  Company Action.  The Company shall not
          amend its Certificate of Incorporation, as amended, or
          participate in any reorganization, transfer of assets,
          consolidation, merger, dissolution, issue or sale of
          securities or any other voluntary action for the purpose of
          avoiding or seeking to avoid the observance or performance
          of any of the provisions of this Article, but will at all
          times in good faith assist in carrying out all of its
          actions as may be reasonably necessary or appropriate in
          order to protect the rights of the Purchaser.

                            ARTICLE VIII - MISCELLANEOUS

               SECTION 8.1  Notices.  All notices, requests, consents
          and other communications hereunder shall be in writing,
          shall be addressed to the receiving party's address set
          forth below or to such other address as a party may
          designate by notice hereunder, and shall be either (i)
          delivered by hand, (ii) made by telex, telecopy or facsimile
          transmission, (iii) sent by overnight courier, or (iv) sent
          by registered mail, return receipt requested, postage
          prepaid.

          If to Lilly:                  Eli Lilly and Company
                                        Lilly Corporate Center
                                        Indianapolis, IN 46285
                                        Attn:  General Counsel
                                        Fax:   317/276-3861

          If to the Company:            Seragen, Inc.
                                        97 South Street
                                        Hopkinton, MA  01748
                                        Attn: President
                                        Fax:  508/435-9805

                       Page 23 of 34 pages

               All notices, requests, consents and other
          communications hereunder shall be deemed to have been given
          either (i) if by hand, at the time of the delivery thereof
          to the receiving party at the address of such party set
          forth above, (ii) if made by telex, telecopy or facsimile
          transmission, one day after the time that receipt thereof
          has been acknowledged by electronic confirmation or
          otherwise, (iii) if sent by overnight courier, on the next
          business day following the day such notice is delivered to
          the courier service, or (iv) if sent by registered mail, on
          the 5th business day following the day such mailing is made.

               SECTION 8.2  Entire Agreement.  This Agreement,
          including exhibits, or other documents referred to herein,
          embodies the entire agreement and understanding between the
          parties hereto with respect to the subject matter hereof and
          supersedes all prior oral or written agreements and
          understandings relating to the subject matter hereof.  No
          statement, representation, warranty, covenant or agreement
          of any kind not expressly set forth in this Agreement shall
          affect, or be used to interpret, change or restrict, the
          express terms and provisions of this Agreement.

               SECTION 8.3  Amendments.  The terms and provisions of
          the Agreement may be modified, amended or waived, or consent
          for the departure therefrom granted, by written consent of
          the Company and Lilly. No such waiver or consent shall be
          deemed to be or shall constitute a waiver or consent with
          respect to any other terms or provisions of this Agreement,
          whether or not similar.  Each such waiver or consent shall
          be effective only in the specific instance and for the
          purpose for which it was given, and shall not constitute a
          continuing waiver or consent.

               SECTION 8.4  Assignment.  The rights and obligations
          under this Agreement may not be assigned by either party
          hereto without the prior written consent of the other party.

               SECTION 8.5  Benefit.  All statements, representations,
          warranties, covenants and agreements in this Agreement shall
          be binding on the parties hereto and shall inure to the
          benefit of the respective successors and permitted assigns
          of each party hereto.  Nothing in this Agreement shall be
          construed to create any rights or obligations except among
          the parties hereto, and no person or entity shall be
          regarded as a third-party beneficiary of this Agreement.

               SECTION 8.6  Governing Law.  This Agreement and the
          rights and obligations of the parties hereunder shall be
          construed in accordance with and governed by the law of the
          Commonwealth of Massachusetts, without giving effect to the
          conflict of law principles thereof.

               SECTION 8.7  Severability.  In the event that any court
          of competent jurisdiction shall determine that any
          provision, or any portion thereof, contained in this
          Agreement shall be unreasonable or unenforceable in any
          respect, then such provision shall be deemed limited to the
          extent that such court deems it reasonable and enforceable,
          and as so limited shall remain in full force and effect.  In
          the event that such court shall deem any such provision, or
          portion thereof, wholly unenforceable, the remaining
          provisions of this Agreement shall be interpreted as if such
          provision were so excluded and shall nevertheless remain in
          full force and effect.

               SECTION 8.8  Headings and Captions.  The headings and
          captions of the various subdivisions of this Agreement are
          for convenience of reference only and shall in no way
          modify, or affect the meaning or construction of any of the
          terms or provisions hereof.

                         Page 24 of 34 pages

               SECTION 8.9  No Waiver of Rights, Powers and Remedies.
          No failure or delay by a party hereto in exercising any
          right, power or remedy under this Agreement, and no course
          of dealing between the parties hereto, shall operate as a
          waiver of any such right, power or remedy of the party.  No
          single or partial exercise of any right, power or remedy
          under this Agreement by a party hereto, nor any abandonment
          or discontinuance of steps to enforce any such right, power
          or remedy, shall preclude such party from any other or
          further exercise thereof or the exercise of any other right,
          power or remedy hereunder.  The election of any remedy by a
          party hereto shall not constitute a waiver of the right of
          such party to pursue other available remedies.  No notice to
          or demand on a party not expressly required under this
          Agreement shall entitle the party receiving such notice or
          demand to any other or further notice or demand in similar
          or other circumstances or constitute a waiver of the rights
          of the party giving such notice or demand to any other or
          further action in any circumstances without such notice or
          demand.

               SECTION 8.10  Expenses.  Each of the parties shall pay
          its own fees and expenses (including the fees of any
          attorneys, accountants, appraisers or others engaged by such
          party) in connection with this Agreement and the
          transactions contemplated hereby whether or not the
          transactions contemplated hereby are consummated.

               SECTION 8.11  Brokers.  Each of the parties hereto
          represents and warrants to the other that no broker, finder
          or financial consultant has acted on its behalf in
          connection with this Agreement or the transactions
          contemplated hereby in such a way as to create any liability
          on the other.  Each of the parties hereto agrees to
          indemnify and save the other harmless from any claim or
          demand for commission or other compensation by any other
          broker, finder, financial consultant or similar agent
          claiming to have been employed by or on behalf of such party
          and to bear the cost of legal expenses incurred in defending
          against any such claim.

               SECTION 8.12  Publicity.  No party shall issue any
          press releases or otherwise make any public statement with
          respect to the transactions contemplated by this Agreement
          without the prior written consent of the other party, except
          as may be required by applicable law or regulation.

               SECTION 8.13  Confidentiality.  Lilly acknowledges and
          agrees that any information or data it has acquired from the
          Company, which is clearly designated in writing as
          confidential and is not otherwise properly in the public
          domain, was received in confidence.  Lilly agrees not to
          divulge, communicate or disclose, except as may be required
          by law or for the performance of this Agreement, or use to
          the detriment of the Company or for the benefit of any other
          person or persons, or misuse in any way, any confidential
          information of the Company.

               SECTION 8.14  Counterparts.  This Agreement may be
          executed in one or more counterparts, and by different
          parties hereto on separate counterparts, each of which shall
          be deemed an original, but all of which together shall
          constitute one and the same instrument.

                    [Remainder of page intentionally left blank]

                        Page 25 of 34 pages

               IN WITNESS WHEREOF, the undersigned have executed this
          Stock Purchase Agreement this 7th day of April, 1997.

                                        SERAGEN, INC.


                                        By:  s/Reed R. Prior
                                             Name:  Reed R. Prior
                                             Title:  Chairman and
                                                     Chief Executive Officer

                                        ELI LILLY AND COMPANY


                                        By:  s/August M. Watanabe, M.D.
                                             Name:  August M. Watanabe, M.D.
                                             Title:  Executive Vice President

                        Page 26 of 34 pages

                           LIST OF SCHEDULES AND EXHIBITS

          Schedule 3.2    Subsidiaries

          Schedule 3.3    Capitalization

          Schedule 3.5    Exception to Accuracy of Reports and Information

          Exhibit A       Schedule of Exceptions

          Exhibit B       Form of Legal Opinion of Mintz, Levin, Cohn,
                          Ferris, Glovsky and Popeo, P.C.

                       Page 27 of 34 pages

                                    Schedule 3.2

                                    Subsidiaries

          Seragen Technologies, Inc., a Delaware corporation

                       Page 28 of 34 pages

                                    Schedule 3.3

                         Capitalization as of March 31, 1997

                COMMON STOCK           AUTHORIZED     OUTSTANDING

          Common Stock ( excludes      70,000,000      18,048,881
          777 treasury shares)

          OPTIONS AND WARRANTS

          Employee and Director                         6,288,753
          Stock Options

          Common Stock Purchase                        12,159,094
          Warrants

          PREFERRED STOCK

          Preferred Stock              5,000,000           31,202

            Series A (May 1996)            4,000            2,402
            Series B (July 1996)          23,800           23,800
            Series C (September 1996)      5,000            5,000

                        Page 29 of 34 pages

                                  Schedule 3.5

                Exception to Accuracy of Reports and Information

          Accounting Treatment - Series B

          The Company converted $25.0 million of debt into Series B
          Preferred Stock in July 1996.  The Company also issued to
          the debt holders common stock warrants which were valued at
          approximately $8.6 million.  The Company is required to
          reflect the value of these warrants as a dividend and to
          increase the net loss per share by the amount of such
          dividend.  In Seragen's Form 10-Q report for the quarter
          ended September 30, 1996, the Company did not include the
          value of the warrants in the determination of net loss per
          common share.  Accordingly, the Company is restating its
          Form 10-Q for the September 30, 1996 quarter to restate its
          net loss per share to properly reflect the dividend reported
          upon issuance of the warrants.

          Lilly

          Under its agreement with Lilly, the Company received $5.0
          million in August 1994 as an advance against Lilly's future
          purchases of bulk product from the Company.  This payment
          was recorded as deferred revenue due to the refundability of
          the amount received.  In May 1996, the Company amended its
          Sales and Distribution Agreement with Lilly.  The amended
          agreement states that the Company has no obligation to
          refund the $5.0 million advance should no bulk purchases be
          made by Lilly.  The Company is still required to provide
          Lilly with material and pay them a 75% royalty on the
          purchase of such material, up to $5.0 million.  In the
          quarter ended June 30, 1996, Seragen recorded the entire
          $5.0 million as revenue upon the amendment of the original
          agreement.  The Company has determined that it is necessary
          to provide a $1.2 million reserve for the expected cost of
          providing the bulk material after paying a 75% royalty of up
          to $5.0 million.  The Company has determined that it is
          necessary to restate its quarter ended June 30, 1996 to
          provide this reserve in the period in which the $5.0 million
          of revenue was recorded.

                       Page 30 of 34 pages

                                   Exhibit A

                             Schedule of Exceptions

               With respect to Section 3.11, the Company has eight
          agreements which contain registration rights.  Exhibit A-1
          to the Stock Purchase Agreement (the "August 1994
          Agreement") dated as of August 6, 1994 between Lilly and the
          Company is a copy of the principal terms of the registration
          rights set forth in the Agreement and Plan of Corporate
          Reorganization dated May 28, 1985.  Exhibit A-2 to the
          August 1994 Agreement is a copy of the principal terms of
          the registration rights set forth in the Purchase Agreement
          with certain stockholders executed in connection with a
          private placement in July 1988.  Exhibit A-3 to the August
          1994 Agreement is a copy of the principal terms of the
          registration rights set forth in the Stock and Warrant
          Purchase Agreement executed in connection with a private
          placement in February, 1994.  Exhibit A-4 to the August 1994
          Agreement is a copy of the principal terms of the
          registration rights set forth in the Warrant to Purchase
          10,757 shares of Common Stock issued to MMC/GATX Partnership
          No. I.  The Company also has granted registration rights
          pursuant to the following agreements: (a) Subscription and
          Registration Agreement dated as of May 31, 1995 with respect
          to the shares of Common Stock underlying warrants issued to
          guarantors of the Company's bank loans, (b) Shareholders'
          Agreement dated as of November 22, 1995 with respect to
          shares of Common Stock underlying warrants issued to
          investors in Seragen Biopharmaceuticals Ltd., (c)
          Subscription and Registration Agreement dated as of July 1,
          1996 with respect to shares of Common Stock underlying the
          Company's Series B Preferred Stock and related warrants, and
          (d) Subscription Agreement dated as of September 30, 1996
          with respect to shares of a Common Stock underlying the
          Company's Series C Preferred Stock and related warrants.

                        Page 31 of 34 pages

                                   Exhibit B

          Form of Opinion of Mintz, Levin, Cohn, Ferris, Glovsky and
                                  Popeo, P.C.

          Eli Lilly and Company
          Lilly Corporate Center
          Indianapolis, IN 46285

          Ladies and Gentlemen:

               This opinion is furnished to you pursuant to Section
          5.3 of the Stock Purchase Agreement, dated April  , 1997
                                                          --
          (the "Agreement"), between Seragen, Inc., a Delaware
          corporation (the "Company"), and Eli Lilly and Company, an
          Indiana corporation ("Lilly"), relating to the issuance and
          sale by the Company of an aggregate of 1,000,000 shares of
          the Company's common stock, $.01 par value ("Common Stock").
          Capitalized terms used herein and not otherwise defined have
          the same meanings as in the Agreement.

               We have acted as counsel for the Company in connection
          with the Agreement.  In that connection, we have examined
          the following:

               (i)   a certificate of legal existence (long form) and
          good standing relating to the Company issued by the
          Secretary of State of the State of Delaware, dated April__, 1997;

               (ii)  a certificate of foreign qualification and good
          standing relating to the Company issued by the Secretary of
          State of the Commonwealth of Massachusetts, dated April __, 1997;

               (iii)   a copy, certified by the Secretary of State of
          the State of Delaware, of the Restated Certificate of
          Incorporation of the Company, as in effect on the date
          hereof;

               (iv)   the Restated By-Laws of the Company, as in
          effect on the date hereof;

               (v)   such records of the corporate proceedings of the
          Company as we have deemed material; and

               (vi)   such other certificates, records and documents
          as we deemed necessary for the purposes of this opinion.

               Based upon the foregoing, we are of the opinion that:

               (a)   The Company has been duly incorporated and is
          validly existing as a corporation in good standing under the
          laws of its jurisdiction of incorporation, is duly qualified
          to do business as a foreign corporation and is in corporate
          good standing in all other jurisdictions where the ownership
          or leasing of properties or conduct of its business requires
          such qualification, except for jurisdictions in which the
          failure to so qualify would not have a material adverse
          effect on the Company, and has all requisite corporate power
          and authority to own its properties and conduct its business
          as described in the SEC Reports;

               (b)   The certificates evidencing the Shares to be
          delivered hereunder are in due and proper form under
          Delaware law, and when duly countersigned by the Company's
          transfer agent and registrar, and delivered to Lilly or upon
          its order against payment of the agreed consideration
          therefor in accordance with the provisions of the Agreement,
          the Shares represented thereby will be duly authorized and

                        Page 32 of 34 pages

          validly issued, fully paid and nonassessable, and to our
          knowledge will not have been issued in violation of or
          subject to any preemptive rights or other rights to
          subscribe for or purchase securities of the Company;

                    (c)   Except as disclosed in the Agreement, to our
                    knowledge, there is no outstanding option, warrant
                    or other right calling for the issuance of, and no
                    commitment, plan or arrangement to issue, any
                    shares of capital stock of the Company or any
                    securities convertible into or exchangeable for
                    capital stock of the Company;

                    (d)   The Company has the requisite corporate
                    power and authority to enter into the Agreement
                    and to sell and deliver the Shares to be sold by
                    it; the Agreement has been duly and validly
                    authorized by all necessary corporate action by
                    the Company, has been duly and validly executed
                    and delivered by and on behalf of the Company, and
                    is a valid and binding agreement of the Company,
                    enforceable in accordance with its terms, except
                    as enforceability may be limited by general
                    equitable principles, bankruptcy, insolvency,
                    fraudulent conveyance, reorganization, moratorium
                    or other laws affecting creditors' rights
                    generally; and, to our knowledge, no approval,
                    authorization, order, consent, registration,
                    filing, qualification, license or permit of or
                    with any court, regulatory, administrative or
                    other governmental body is required for the
                    execution and delivery of the Agreement by the
                    Company or the consummation of the transactions
                    contemplated thereby except such as have been
                    obtained;

                    (e)   The execution and performance of the
                    Agreement and the consummation of the transactions
                    therein contemplated will not conflict with,
                    result in the breach of, or constitute, either by
                    itself or upon notice or the passage of time or
                    both, a default under, any agreement, mortgage,
                    deed of trust, lease, franchise, license,
                    indenture, permit or other instrument to which the
                    Company is known by us to be a party or by which
                    the Company or any of its property is known by us
                    to be bound or affected which is material to the
                    Company, or violate any of the provisions of the
                    charter or by-laws of the Company, or, to our
                    knowledge, violate any statute, judgment, decree,
                    order, rule or regulation, of any court or
                    governmental body having jurisdiction over the
                    Company or any of its property.

                    (f)   Based in part upon the representations and
                    warranties of Lilly as set forth in Article IV of
                    the Agreement, the offer and sale of the Shares
                    pursuant to the terms of the Agreement are exempt
                    from the registration requirements of Section 5 of
                    the Securities Act; and

                    (g)   Based solely upon a review of regularly
                    accepted unofficial compilations of state
                    securities laws and regulations and without
                    obtaining rulings of authorities administering
                    such laws or opinions of other counsel, no state
                    qualification is required by Indiana state
                    securities laws on the part of the Company in
                    connection with the offer and sale of the Shares
                    pursuant to the terms of the Agreement.

                         Our opinions above are limited to the federal
                    law of the United States of America, the laws of
                    the Commonwealth of Massachusetts, the General
                    Corporation Law of the State of Delaware and,

                         Page 33 of 34 pages

                    subject to the limitations described in paragraph
                    (g) above, the securities laws of the State of
                    Indiana, and we express no opinion with respect to
                    the laws of any other jurisdiction.  No opinion is
                    expressed herein with respect to the registration
                    of the Shares, or the qualification of the Shares
                    for an exemption therefrom, under the securities
                    or Blue Sky laws of any other state or any foreign
                    jurisdiction.  No opinion is given with respect to
                    the accuracy or completeness of any disclosures of
                    the Company to you in connection with the issuance
                    of the Shares, or to compliance with the anti-
                    fraud provisions of federal or state securities
                    laws in connection with such issuance.

                         This opinion is intended solely for your
                    benefit in connection with the transactions
                    contemplated by the Agreement and may not be
                    relied upon by you for any other purpose; nor may
                    it be communicated to, or reproduced, filed
                    publicly or relied upon by, any other person or
                    entity for any purpose without our express prior
                    written consent.

                                        Very truly yours,


                                        Mintz, Levin, Cohn, Ferris,
                                        Glovsky and Popeo, P.C.

                                Page 34 of 34 pages