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As filed with the Securities and Exchange Commission on April 20, 1995
                                             Registration No. 33-38347
______________________________________________________________________


                       SECURITIES AND EXCHANGE COMMISSION
                            WASHINGTON, D.C. 20549
                 
                                 ____________

                         POST-EFFECTIVE AMENDMENT NO. 1
                                       TO
                                    FORM S-3
                             REGISTRATION STATEMENT
                                     UNDER
                           THE SECURITIES ACT OF 1933
                                 ____________

                              ELI LILLY AND COMPANY
             (Exact name of registrant as specified in its charter)

                                 ____________

           Indiana                                   35-0470950
  (State or other jurisdiction                    (I.R.S. Employer
of incorporation or organization)                Identification No.)


                             Lilly Corporate Center
                          Indianapolis, Indiana 46285
                                 317-276-2000
         (Address, including zip code, and telephone number, including
             area code of registrant's principal executive offices)

                                 ____________

                              REBECCA O. GOSS, Esq.
                       Vice President and General Counsel
                              Eli Lilly and Company
                              Lilly Corporate Center
                           Indianapolis, Indiana 46285
                                  317-276-2000
            (Name, address, including zip code, and telephone number,
                   including area code of agent for services)
                 
                                 ____________

                                  Copies to:

Steven P. Lund, Esq.                           Keith L. Kearney, Esq.
Dewey Ballantine                               Davis Polk & Wardwell
1301 Avenue of the Americas                    450 Lexington Avenue
New York, New York 10019-6092                 New York, New York 10017

______________________________________________________________________




     By filing this Post-Effective Amendment No. 1 to its Registration
Statement with the Securities and Exchange Commission (the "Commission"),
the Registrant is requesting the deregistration of $24,250,000 aggregate
principal amount of Debt Securities.  Registrant previously registered
$500,000,000 aggregate principal amount of Debt Securities with the 
Commission.



                                   SIGNATURES

     Pursuant to the requirements of the Securities Act of 1933, the
Registrant certifies that it has reasonable grounds to believe that it
meets all of the requirements for filing on Form S-3 and has duly
caused this Amendment to the Registration Statement to be signed on 
its behalf by the undersigned, thereunto duly authorized, in the City
of Indianapolis, State of Indiana, on April 17, 1995.

                          ELI LILLY AND COMPANY

                          By /s/  Randall L. Tobias
                             _________________________________________
                             (Randall L. Tobias, Chairman of the Board
                              and Chief Executive Officer)

     Pursuant to the requirements of the Securities Act of 1933, this
Amendment to the Registration Statement has been signed by the
following persons in the capacities and on the date indicated.

          Signature                         Title                   Date


/s/  Randall L. Tobias                Chairman of the Board,    April 17, 1995
___________________________________    Chief Executive
    (Randall L. Tobias)                Officer, and a 
                                       Director (principal 
                                       executive officer)


/s/  James M. Cornelius               Vice President, Finance,  April 17, 1995
___________________________________    Chief Financial
    (James M. Cornelius)               Officer, and a Director
                                       (principal financial 
                                       officer)


/s/  Arnold C. Hanish                 Chief Accounting Officer  April 17, 1995
___________________________________    (principal accounting
    (Arnold C. Hanish)                 officer)


/s/  Steven C. Beering, M.D.          Director                  April 17, 1995
___________________________________
    (Steven C. Beering, M.D.)


                                     Director                  April 17, 1995
___________________________________
    (James W. Cozad)


/s/  Alfred G. Gilman, M.D., Ph.D.    Director                  April 17, 1995
___________________________________
   (Alfred G. Gilman, M.D., Ph.D.)







          Signature                         Title                   Date

/s/ Karen N. Horn, Ph.D.                  Director              April 17, 1995
________________________________________
   (Karen N. Horn, Ph.D.)


/s/ J. Clayburn La Force, Jr., Ph.D.      Director              April 17, 1995
________________________________________
   (J. Clayburn La Force, Jr., Ph.D.)


/s/ Kenneth L. Lay, Ph.D.                 Director              April 17, 1995
________________________________________
   (Kenneth L. Lay, Ph.D.)


/s/ Franklyn G. Prendergast, M.D., Ph.D.  Director              April 17, 1995
________________________________________
  (Franklyn G. Prendergast, M.D., Ph.D.)


/s/ Kathi P. Seifert                      Director              April 17, 1995
________________________________________
   (Kathi P. Seifert)


/s/ Stephen A. Stitle                     Director              April 17, 1995
________________________________________
   (Stephen A. Stitle)


/s/ Sidney Taurel                         Director              April 17, 1995
________________________________________
   (Sidney Taurel)


/s/ August M. Watanabe, M.D.              Director              April 17, 1995
________________________________________
   (August M. Watanabe, M.D.)


/s/ Alva O. Way                           Director              April 17, 1995
________________________________________
   (Alva O. Way)


/s/ Richard D. Wood                       Director              April 17, 1995
________________________________________
   (Richard D. Wood)















                                        April 20, 1995


Securities and Exchange Commission
450 Fifth Street, N.W.
Washington, D.C.  20549

          Re:  Eli Lilly and Company Post-Effective 
               Amendment No. 1 to Form S-3 Registration
               Statement (Registration No. 33-38347)
               ________________________________________

Dear Sirs:

     On behalf of Eli Lilly and Company (the "Company"),
transmitted herewith by electronic transmission under the EDGAR
system is Post-Effective Amendment No. 1 to the Registration
Statement on Form S-3 (Registration No. 33-38347) (the "Amendment").

     By this Amendment, the Company is deregistering $24,250,000
aggregate principal amount of Debt Securities.

     Should you have any questions in connection with this filing,
please call me collect at (212) 259-6746.

                                        Very truly yours, 


                                        Joon S. Kim


Enclosures