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                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549
 
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                                 SCHEDULE 14D-1
 
              TENDER OFFER STATEMENT PURSUANT TO SECTION 14(D)(1)
                     OF THE SECURITIES EXCHANGE ACT OF 1934
 
                               (AMENDMENT NO. 4)
 
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                              MCKESSON CORPORATION
                           (NAME OF SUBJECT COMPANY)
 
                          ECO ACQUISITION CORPORATION
                          A WHOLLY OWNED SUBSIDIARY OF
                             ELI LILLY AND COMPANY
                                   (BIDDERS)
 
COMMON STOCK, $2.00 PAR VALUE PER SHARE               581556 10 7
   (INCLUDING THE ASSOCIATED RIGHTS)     (CUSIP NUMBER OF CLASS OF SECURITIES)
     (TITLE OF CLASS OF SECURITIES)
 
                                J.B. KING, ESQ.
                       VICE PRESIDENT AND GENERAL COUNSEL
                             ELI LILLY AND COMPANY
                             LILLY CORPORATE CENTER
                          INDIANAPOLIS, INDIANA 46285
                                 (317) 276-2000
         (NAMES, ADDRESSES AND TELEPHONE NUMBERS OF PERSONS AUTHORIZED
           TO RECEIVE NOTICES AND COMMUNICATIONS ON BEHALF OF BIDDER)
 
                                WITH A COPY TO:
 
                             BERNARD E. KURY, ESQ.
                                DEWEY BALLANTINE
                          1301 AVENUE OF THE AMERICAS
                            NEW YORK, NEW YORK 10019
                                 (212) 259-7400
 
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  This Amendment No. 4 to the Schedule 14D-1 relates to a tender offer by ECO
Acquisition Corporation (the "Purchaser"), a Delaware corporation and a wholly
owned subsidiary of Eli Lilly and Company, an Indiana corporation ("Parent"),
to purchase all outstanding shares of common stock, par value $2.00 per share
and the associated Rights (as defined in the Offer to Purchase) (collectively,
the "Shares"), of McKesson Corporation (the "Company"), a Delaware corporation,
at a purchase price of $76.00 per Share, net to the seller in cash, without
interest, upon the terms and subject to the conditions set forth in the Offer
to Purchase, dated July 15, 1994 (the "Offer to Purchase"), and the related
Letter of Transmittal (which together constitute the "Offer"), copies of which
were attached as Exhibits (a)(1) and (a)(2), respectively, to the Schedule 14D-
1 filed with the Securities and Exchange Commission on July 15, 1994 as amended
by Amendment Nos. 1, 2 and 3 thereto dated July 27, 1994, August 10, 1994 and
September 7, 1994, respectively (collectively, the "Schedule 14D-1"). The
purpose of this Amendment No. 4 is to amend and supplement Item 11 of the
Schedule 14D-1 as described below.
 
ITEM 11. MATERIAL TO BE FILED AS EXHIBITS.
 
 
  (a)(21)   --Form of press release issued by Parent on September 21, 1994.
 

 
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                                   SIGNATURE
 
  AFTER DUE INQUIRY AND TO THE BEST OF ITS KNOWLEDGE AND BELIEF, EACH OF THE
UNDERSIGNED CERTIFIES THAT THE INFORMATION SET FORTH IN THIS STATEMENT IS TRUE,
COMPLETE AND CORRECT.
 
                                          Eli Lilly and Company
 
                                              
                                          By:     /s/ James M. Cornelius
                                              ---------------------------------
                                              Name:  James M. Cornelius
                                              Title: Vice President, Finance and
                                                     Chief Financial Officer
 
                                          ECO Acquisition Corporation
 
                                                 /s/ Charles E. Schalliol
                                          By: _________________________________
                                            Name: Charles E. Schalliol
                                            Title:   President
 
Dated: September 21, 1994
 
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                                                                 EXHIBIT (A)(21)
 
                                          September 21, 1994 For Release
                                          Immediately
                                          Refer to (317) 276-3655
 
                      LILLY EXTENDS MCKESSON TENDER OFFER
 
  Eli Lilly and Company (NYSE:LLY) announced today that it is extending its
offer to purchase all outstanding shares of common stock of McKesson
Corporation for $76.00 per share in cash until 5:00 p.m., New York City time,
on Tuesday, October 11, 1994.
 
  The terms of the extended offer are identical to the terms of the original
offer announced on July 11,1994. Therefore, in addition to Lilly's offer of
$76.00 per share in cash, McKesson Corporation will, immediately prior to the
consummation of the tender offer, distribute to its stockholders one share of
common stock of a newly formed McKesson corporation for each share in the old
McKesson Corporation.
 
  As previously announced, a request for additional information was made by the
Federal Trade Commission (FTC) pursuant to the Hart-Scott-Rodino Antitrust
Improvements Act in connection with Lilly's acquisition of McKesson's PCS
Health Systems, Inc., business. The offer is being extended to provide time for
Lilly and McKesson to complete their submissions to the FTC and for McKesson to
transfer all its non-PCS assets and liabilities to the newly formed corporation
and distribute the common stock of such corporation to McKesson stockholders.
For these reasons, it may be necessary to further extend the offer.
 
  As of Tuesday, September 20, 1994, approximately 15,168,000 shares of
McKesson common stock had been tendered.
 
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